CN115154375B - Stable cleaning composition with repairing and relieving effects - Google Patents
Stable cleaning composition with repairing and relieving effects Download PDFInfo
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- CN115154375B CN115154375B CN202210993168.1A CN202210993168A CN115154375B CN 115154375 B CN115154375 B CN 115154375B CN 202210993168 A CN202210993168 A CN 202210993168A CN 115154375 B CN115154375 B CN 115154375B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a stable cleaning composition with repairing and relieving effects, which comprises the following components in parts by weight: 10-30 parts of caprylic/capric triglyceride, 1-10 parts of PEG-20 triisostearate, 1-8 parts of frankincense resin extract, 1-7 parts of tripeptide-1 copper, 1-10 parts of camellia seed oil, 1-10 parts of jojoba seed oil, 1-10 parts of avocado oil, 8-15 parts of shea butter, 4-16 parts of wild lacquer fruit wax and 1-10 parts of rose-in seed oil. The composition can effectively clean facial skin and body skin, can clean the skin without damaging the skin, effectively repair and relieve the skin state, and protect the barrier of the skin, and is different from the prior barrier of the skin or thinning the cuticle when other cleaning substances are cleaned. Can solve the problems of skin cosmetic residue, dirt adhesion, incomplete cleaning, etc.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a stable cleaning composition with repairing and relieving effects.
Background
When a large amount of makeup is left on the skin, the burden is easily brought to the metabolism of the skin, and the self updating time is reduced. Particularly in the eyes, the aging phenomenon is obvious, and the skin becomes aged with time and the fine lines of the tunnels are formed. Besides the accelerated aging, the color cosmetics can cause pigment to be deposited on the skin in a large amount, and finally the color of lips and even eyelid can be deepened, so that the color of the skin can be obviously deepened after long-term use. For people who make up frequently, the common facial cleanser cannot clean the makeup residues on the skin, so that the condition of the skin can be greatly changed, and the skin is continuously attacked by large oil fields, acne muscles and darkness. Therefore, the primary problem of skin is that the skin is clean, deep cleaning is not thorough, and the subsequent care product cannot be absorbed well.
Skin care products and cosmetics are different in nature, and skin absorbs nutrition in the skin care products to be healthier, but if too much chemical substances in the cosmetics with heavy texture are absorbed, pores are blocked, and gradual skin cannot be penetrated, so that acnes and pores are large. The face can be coated with a layer of cosmetics to immediately play roles in modifying skin color and covering flaws, which is an advantage, but the skin grinding effect of the cosmetics is good, the pigment content is high, if the cosmetics are not removed for a long time, pigments in the makeup products can be deposited on the skin, the skin color can be gradually dark and yellow, and signs of aging are generated.
Therefore, the design of the repairing and soothing cleaning formula is based on the dual effects of repairing and soothing the skin, and the skin is not damaged on the basis of cleaning the skin, and the skin barrier is not damaged. For people who often make up and are not thoroughly cleaned, it is important to develop a composition which can thoroughly clean the skin without damaging the skin and has repairing and soothing effects.
Disclosure of Invention
The invention aims to provide a stable cleaning composition with repairing and relieving effects, which can effectively clean skin, repair damaged skin and relieve the sensitive state of skin.
The technical scheme adopted by the invention is that the stable cleaning composition with repairing and relieving effects comprises the following components in parts by weight: 10-30 parts of caprylic/capric triglyceride, 1-10 parts of PEG-20 triisostearate, 1-8 parts of olibanum resin extract, 1-7 parts of tripeptide-1 copper, 1-10 parts of camellia seed oil and 1-10 parts of jojoba seed oil.
The present invention is also characterized in that,
preferably, the composition further comprises 1-10 parts of avocado oil and 8-15 parts of avocado fruit tree fruit fat.
Preferably, the composition further comprises 4-16 parts of wild lacquer fruit wax and 1-10 parts of rose-in-rust oil.
Preferably, a stable and repairing and soothing cleaning composition comprises the following components in parts by weight: 15-25 parts of caprylic/capric triglyceride, 2-8 parts of PEG-20 triisostearate, 2-7 parts of olibanum resin extract, 2-6 parts of tripeptide-1 copper, 2-8 parts of camellia seed oil and 2-8 parts of jojoba seed oil.
Preferably, a stable and repairing and soothing cleaning composition comprises the following components in parts by weight: 16 to 22 parts of caprylic/capric triglyceride, 3 to 7 parts of PEG-20 triisostearate, 3 to 6 parts of olibanum resin extract, 3 to 6 parts of tripeptide-1 copper, 3 to 7 parts of camellia seed oil, 3 to 7 parts of jojoba seed oil, 2 to 8 parts of avocado oil and 9 to 13 parts of shea butter.
Preferably, a stable and repairing and soothing cleaning composition comprises the following components in parts by weight: 16 to 22 parts of caprylic/capric triglyceride, 3 to 7 parts of PEG-20 triisostearate, 3 to 6 parts of frankincense resin extract, 3 to 6 parts of tripeptide-1 copper, 3 to 7 parts of camellia seed oil, 3 to 7 parts of jojoba seed oil, 2 to 8 parts of avocado oil, 9 to 13 parts of shea butter, 5 to 15 parts of wild lacquer fruit wax and 2 to 8 parts of rose-in seed oil.
The beneficial effects of the invention are as follows:
the composition can effectively clean facial skin and body skin, can clean the skin without damaging the skin, effectively repair and relieve the skin state, and protect the barrier of the skin, and is different from the prior barrier of the skin or thinning the cuticle when other cleaning substances are cleaned. Can solve the problems of skin cosmetic residue, dirt adhesion, incomplete cleaning, etc.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
The stable cleaning composition with repairing and relieving effects can be used as an additive of skin care cleaning products to be added into skin care cleaning products such as cleansing cream, bath cream, cleaning gel and the like. In production, the selection and preparation process of other components in the skin care product can be carried out according to the conventional operation in the field.
The caprylic/capric triglyceride in the composition is clear to light yellow, is a high-refreshing odorless grease, and belongs to the derivatives of palm oil or coconut oil. It is an excellent moisturizing oil, has good spreadability, makes skin have a slippery but not greasy feel, and is easily absorbed by skin. Has good effect on the uniformity and fineness of cosmetics, and can lubricate and shiny skin. Because it has the compatible characteristic with human skin, it has the non-greasy feel, has the effects of lubricating and softening skin, has the function of filtering ultraviolet light, and is a natural vegetable oil. Has been shown to be non-irritating to humans and does not clog pores. The caprylic/capric triglyceride is stable, can be stored for more than 6 months after being unsealed, and is widely applied to industries such as food, medicine, cosmetics and the like.
PEG-20 triisostearate is a surfactant frequently used in cleansing products, and has the greatest advantages of high emulsifying speed, low irritation, good cleansing ability and no residual feel after washing. Has excellent makeup removing capability, excellent self-emulsifying property and mild and non-irritating property. Is an emulsifier derived from isostearic acid, and is not prone to skin irritation. Has higher oxidation stability compared with oleic acid derivatives. The anti-freezing agent is not turbid and precipitated at high and low temperatures, and is suitable for transparent formulas. The cleansing cream has strong cleansing ability and good cleansing effect, and is suitable for cleansing thick cosmetics.
The olibanum resin extract in the composition is a yellow-white powdery flowable extract product of resin of the olibanum tree of the olive family, and is a natural source raw material. The olibanum resin extract has the main functions of controlling oil, resisting seborrhea, resisting inflammatory and resisting oxidation in cosmetics and skin care products, and is safer, and the olibanum resin extract has no acne-causing property. The active peptide has good activation effect on a peroxisome activated receptor, plays an important role in the healing process of skin injury and has good anti-inflammatory property; can enhance lipase activity, promote lipolysis, and can be used in slimming products or oily skin washing products; has effect in promoting caspase activation, prolonging cell life, and resisting aging; is suitable for skin of 7 types, such as skin tightening, oily skin, non-pigmented skin, wrinkle skin, pigmented skin, dry skin, and sensitive skin. Can be well fused with skin fat and cosmetics in the aspect of cleaning, further thoroughly takes away skin impurities and dirt in the cleaning stage, has no residue, is applicable to sensitive skin, can regulate skin greasiness, and has better anti-inflammatory and protective properties to damaged skin or sensitive skin. These characteristics make up for the deficiencies and gaps of the cleansing products in repairing and protecting the skin, not only pay attention to the cleansing effect, but also repair, ease and protect the relevant problems such as barrier damage, sensitivity and the like which occur when the skin is cleaned.
Tripeptide-1, also called dermal growth factor, in the composition of the invention acts mainly on the dermis of the skin, and can promote the synthesis of extracellular matrix such as collagen and glycosaminoglycan, strengthen the dermis, make the skin thicker, tighten, ease wrinkles and have stronger resistance to ultraviolet radiation. In addition, tripeptide-1 can transport various functional components to the bottom layer of the skin through a liposome conduction system to prevent the formation of new fat cells. The main function of the anti-oxidant in cosmetics and skin care products is that the risk factor is 1, and the anti-oxidant is safer and has no acne-causing property. Has effects in promoting collagen, elastin, hyaluronic acid, etc., and resisting aging and wrinkle. Tripeptide-1 is a signal peptide which is effective in subcutaneous tissue and can promote the generation of proteoglycans such as type I and III collagens and elastin, and structural glycoproteins such as laminin and chemofibronectin, promote wound repair and mechanism upgrading reconstruction, promote subcutaneous tissue, enable skin to be more and more compact and enable wrinkles to be relieved. Can reasonably prevent and fade wrinkles, and make skin younger, smoother and ductile.
Tripeptide-1 copper, the alias is tripeptide, blue copper peptide. The main functions of the cosmetic and the skin care product are moisturizer, antioxidant and anti-inflammatory agent, and the cosmetic and the skin care product have no acne-causing property. The copper peptide and the copper complex thereof can be used as an activator and an antioxidant for tissue remodeling, and are also signal peptide for promoting the degradation of a large amount of collagen aggregates outside scars, the synthesis of normal collagen of skin, the generation of elastin, proteoglycan and glycosaminoglycan, the growth speed and migration of different cell types, and anti-inflammatory and antioxidant reactions. The blue copper peptide can effectively promote the generation of collagen and elastin, and has the anti-oxidation and anti-aging capabilities. Tripeptide-1 and tripeptide-1 copper complement each other to provide the cleaning composition with a repair, soothing and antioxidant effect in many aspects. Breaks through the single cleaning concept of the traditional skin cleaning products, provides beneficial effects for the skin as much as possible while cleaning, and can not supplement nutrition in a short time, but can make the skin cared anytime and ensure that the original nutrition is not lost.
The camellia seed oil in the composition is extracted from wild woody oil plant 'oil tea fruit', and has good health care effect on skin. Unsaturated fatty acid is called as "beauty acid", and the content of unsaturated fatty acid in camellia oil is up to 93%, in fact, the base oil of cosmetics is made of tea oil and olive oil, and only the two oils can be used as the base oil of cosmetics, because the nutrients contained in the two oils are needed by human body and can be directly absorbed by skin. Only tea oil can be eaten or used as cosmetics, and can be used as essential oil to be mixed with other nutritional components and absorbed through skin. The camellia seed oil is a substance obtained from camellia seeds by cold pressing and solvent extraction, and contains various physiological active substances such as rich monounsaturated and polyunsaturated fatty acids, squalene, vitamin E, phytosterol, camellia saponin, tea polyphenol, flavonoid compounds and the like. The skin-friendly liquid has good skin-friendly property, can quickly permeate into skin, supplements antioxidant substances such as unsaturated fatty acid, squalene, vitamin E, polyphenol, flavonoid compounds and the like, directly eliminates harmful active oxygen and active nitrogen, and can promote the synthesis of antioxidant enzymes and antioxidant substances of cells; the camellia seed oil is rich in tea polyphenol, vitamin E and other substances, and the content of the camellia seed oil is higher than that of olive oil, so that tyrosinase activity can be obviously inhibited, melanin synthesis is reduced, and the effects of removing freckles and whitening are achieved; in addition, the tea polyphenol can promote the growth of skin horns to play cells, maintain the proliferation cycle of the cells, inhibit the apoptosis of normal skin horns, and further delay aging. In conclusion, the camellia seed oil contains abundant nutrients, so that the camellia seed oil has good effects of resisting oxidation, resisting inflammation, repairing, whitening and the like, and is a natural cosmetic raw material with great potential.
The jojoba seed oil in the composition disclosed by the invention is a plant grown in Mexico, has good permeability and also has the characteristic of high temperature resistance. Jojoba seed oil has a chemical molecular arrangement very similar to human sebum and is very easily liked and absorbed by the skin. Strictly speaking, the jojoba seed oil belongs to waxy texture rather than liquid texture, can be melted and absorbed by skin immediately as long as the jojoba seed oil is condensed when being cooled, has quite obvious beautifying effect on skin, can be used for smoothing pores, regulating grease secretion of oily or mixed skin, improving skin inflammation and sensitivity, eczema, psoriasis, facial blebs and the like, has the other characteristics of hydrophilicity, has the function of regulating moisture on skin, and is a very good natural skin care maintenance component. Jojoba seed oil provides two layers of action to the skin: rapidly penetrate, absorb and soften skin cutin to make skin soft and elastic. Has remarkable beautifying effect on skin, can smooth capillary pores, regulate the secretion of grease of oily or mixed skin, and improve inflamed skin, eczema, psoriasis, facial blebs and the like. It has good therapeutic effect and is suitable for allergic skin, and can restore activity and luster for dry wrinkle skin. The skin care product contains important natural vitamins of skin, collagen protein with high trophism and mineral substances, can massage and protect skin, avoid water loss, nourish and deeply care skin, make skin luster have elasticity, and alleviate injury of wind, sun and sun to skin.
The avocado oil in the composition is base oil with quite high nutritive value, has the characteristic of moist grease, and is very suitable for dry skin. Especially, the extremely dry skin contains vitamin D higher than eggs, is suitable for dry, fragile, sun-dried and swollen skin, increases skin elasticity, water loss and lacks elastic skin, and promotes hair growth. The penetration of avocado oil is inferior to that of jojoba oil, and the avocado oil can clean deep skin layers, eliminate wrinkles, lighten black spots and freckles, and is suitable for people with neutral skin, dryness and sensitivity. Not only can be used singly, but also can be used in a matching way, avocado oil and jojoba seed oil can be used in a matching way, and the penetration is enhanced by combining the avocado oil and jojoba seed oil, so that the avocado seed oil and jojoba seed oil is a very good natural antioxidant. Avocado oil also contains a large amount of vitamin E, witch hazel and lecithin, can help skin to increase resistance, moisten and moisturize, is easy to permeate, and has anti-aging effect.
The butter fruit fat in the composition is natural oil extracted from fruits of the butter tree, the mass fraction of unsaponifiable matters in the butter fruit fat is as high as 9% -13%, and the natural moisturizing factors in the butter fruit fat and the moisturizing agent extracted from sebaceous glands have the same components, so that the butter fruit fat itself becomes a natural vitamin A cream, and therefore, the butter fruit fat is regarded as the most effective natural skin moisturizing agent and conditioning agent. The butter oil contains cinnamate, so that the butter oil can be used for preventing skin injury caused by ultraviolet irradiation in sunscreen cosmetics, and natural emulsion in the butter oil can also prevent skin allergy caused by sunlight irradiation. The butter has effects in promoting cell regeneration and capillary circulation, and can be used for skin care product for preventing and delaying skin aging. The butter has strong water locking capacity and good affinity to skin, and vitamin A in the butter has important improvement effects on the removal of a plurality of skin defects such as wrinkles, eczema and the like. Can be effectively utilized in skin care products and beauty products, has extremely high moisturizing factors, and can effectively moisturize skin for 6 hours by selecting skin care products containing butter fruit tree fruit fat when the skin is dry or weather is dry, so that the skin is in a moist and smooth state for a long time, the grease lacking in human epidermal cells can be supplemented, and various basic elements required for maintaining the physiological balance of the skin are provided.
The wild lacquer fruit wax in the composition is a pure natural plant wax, is obtained by squeezing lacquer fruit peel, and mainly comprises C16-18 fatty acid glyceride, the chemical structure determines the softness of the wild lacquer fruit wax, the wild lacquer fruit wax can generate very smooth texture, the texture of oil-in-water emulsion is greatly improved, and the linoleic acid content of the wild lacquer fruit wax is up to more than 60 percent. The wild lacquer fruit wax is crystallized finely, and contains the diglyceride, so that the wild lacquer fruit wax has fine texture, penetrability, viscosity and smoothness which are not available in common fat, and can give the product a glossy feel. The adhesive degree between the components of the product can be increased, meanwhile, the fluidity of the product can be improved, the stability of the product can be regulated, and the quality of the product can be improved.
The rose seed oil is rose shrub seed, and the main active ingredients are vitamin A and vitamin C, and has the anti-aging effect, and can promote skin rejuvenation, increase skin elasticity, tighten and moisturize. Has proliferation activity on vascular endothelial cells, can enhance the intensity of blood vessels, and can prevent skin red blood wires; the inhibition of elastase reflects the anti-wrinkle performance, and the combination has SOD-like activity, and can be used for anti-aging cosmetics. The addition of the wild lacquer fruit wax and the rose-in seed oil ensures that the formula system is more stable, and the cleaning composition not only has a certain cleaning force under the multi-effect condition of the natural vegetable oil, but also has the effects of enhancing and relieving and repairing compared with the prior cleaning force under the condition of mutually matching various substances, and simultaneously solves the problem that many prior cleaning skin care products are not considered on the basis, so that the synergistic effect is far stronger than the combined effect of the two.
The caprylic/capric triglyceride of the invention is purchased from Croda Singapore Pte Ltd, PEG-20 triisostearate is purchased from Shanghai North trade Co Ltd, boswellia resin extract is purchased from Shanghai Rui Rhinocerotis trade Co Ltd, avocado oil is purchased from Shanghai Rong Hai biosciences Co., butyrospermum fruit oil is purchased from A Hu Sika L oil (Zhang Kong) Co., buddha wax is purchased from Henan Fumei biosciences Co., camellia seed oil is purchased from Shanghai Boehringer biosciences Co., ltd, jojoba seed oil is purchased from Vantage Specialty Chemicals, inc. rust red rose seed oil is purchased from Northstar Lipids (UK) LTD.
The tripeptide-1, also called GHK tripeptide, adopted by the invention is produced by Shaanxi Huikang biotechnology Limited liability company;
the preparation method of the tripeptide-1 copper adopted by the invention comprises the following steps: adding the GHK tripeptide into purified water, wherein the mass ratio of the GHK tripeptide to the purified water is 1:1, then adding copper acetate (the mass of the copper acetate is 3 times of that of the GHK tripeptide), adjusting the pH value to 8.0, reacting for 2-3 hours, and filtering impurities; concentrating to obtain oil, adding absolute ethanol, stirring, adding ethyl acetate, stirring, filtering to obtain wet GHK-Cu, drying, and pulverizing to obtain GHK-Cu (tripeptide-1 copper).
The caprylic/capric triglyceride in the composition of the invention provides a refreshing skin feel when the cleaning composition is used as a natural solvent; PEG-20 triisostearate, as a nonionic surfactant in cleansing compositions, is mild in nature and has low skin irritation; the Boswellia carterii resin extract can enhance lipase activity in cleaning composition as skin conditioner, and promote lipolysis, and remove excessive oil on skin in cleaning composition; tripeptide-1 has antioxidant effect, can promote the generation of collagen, elastin, hyaluronic acid, etc., and has antiaging, anti-wrinkle, and skin activating effects; tripeptide-1 copper, which is effective in promoting collagen and elastin formation in cleaning compositions, has antioxidant and anti-aging properties; the camellia seed oil has good skin affinity, can quickly permeate into skin in the cleaning composition, supplements antioxidant substances such as unsaturated fatty acid, squalene, vitamin E, polyphenol, flavonoid compounds and the like, directly eliminates harmful active oxygen and active nitrogen, and can promote the synthesis of antioxidant enzymes and antioxidant substances of cells; the camellia seed oil is rich in tea polyphenol, vitamin E and other substances, and the content of the camellia seed oil is higher than that of olive oil, so that tyrosinase activity can be obviously inhibited, melanin synthesis is reduced, and the effects of removing freckles and whitening are achieved; in addition, the tea polyphenol can promote the growth of skin keratin cells, maintain the proliferation cycle of the cells, inhibit the apoptosis of normal skin keratin cells, and further delay aging; jojoba seed oil, which is used as a moisturizing agent in the cleaning composition, has the characteristics of difficult oxidation, high temperature resistance, high pressure resistance, small viscosity change and the like, has better touch sense and ductility than other vegetable oil, can make skin soft and elastic, and is easy to be absorbed by skin; avocado oil has good permeability to skin and can be used as carrier for various substances; has surface activity, mild skin effect, good softening and sterilizing effects, and certain sun-screening performance; the butter has strong water locking capability and good affinity to skin when being used as a natural skin moisturizing agent and a conditioner in the cleaning composition; the wild lacquer fruit wax can increase the bonding degree among the components of the product when the cleaning composition is used as an adhesive, so that the wild lacquer fruit wax has enough strength, and meanwhile, the fluidity of the product can be improved, the stability of the product can be regulated, and the quality of the product can be improved; the rose-in oil has proliferation activity on vascular endothelial cells in the cleaning composition as emollient, can enhance the intensity of blood vessels, and can prevent skin red blood streak.
Example 1
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of olibanum resin extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia seed oil and 2g of jojoba seed oil.
Example 2
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 22g of caprylic/capric triglyceride, 3g of PEG-20 glycerol triisostearate, 0.9g of olibanum resin extract, 0.7g of tripeptide-1, 1.7g of tripeptide-1 copper, 4g of camellia seed oil and 4g of jojoba seed oil.
Example 3
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 24g of caprylic/capric triglyceride, 5g of PEG-20 glycerol triisostearate, 1.2g of olibanum resin extract, 0.9g of tripeptide-1, 2g of tripeptide-1 copper, 6g of camellia seed oil and 6g of jojoba seed oil.
Example 4
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 26g of caprylic/capric triglyceride, 7g of PEG-20 glycerol triisostearate, 1.5g of olibanum resin extract, 1.2g of tripeptide-1, 4g of tripeptide-1 copper, 8g of camellia seed oil and 8g of jojoba seed oil.
Example 5
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 28g of caprylic/capric triglyceride, 9g of PEG-20 glycerol triisostearate, 2g of olibanum resin extract, 1.5g of tripeptide-1, 6g of tripeptide-1 copper, 10g of camellia seed oil and 10g of jojoba seed oil.
Example 6
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of olibanum resin extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia seed oil, 2g of jojoba seed oil, 2g of avocado oil and 3g of avocado fruit oil.
Example 7
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 23g of caprylic/capric triglyceride, 4g of PEG-20 triisostearate, 1g of olibanum resin extract, 0.8g of tripeptide-1, 1.8g of tripeptide-1 copper, 5g of camellia seed oil, 5g of jojoba seed oil, 3g of avocado oil and 4g of avocado fruit oil.
Example 8
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 25g of caprylic/capric triglyceride, 6g of PEG-20 triisostearate, 1.3g of olibanum resin extract, 1.1g of tripeptide-1, 3g of tripeptide-1 copper, 7g of camellia seed oil, 7g of jojoba seed oil, 4g of avocado oil and 6g of avocado fruit oil.
Example 9
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 28g of caprylic/capric triglyceride, 9g of PEG-20 triisostearate, 2g of olibanum resin extract, 1.5g of tripeptide-1, 6g of tripeptide-1 copper, 10g of camellia seed oil, 10g of jojoba seed oil, 6g of avocado oil and 8g of shea butter.
Example 10
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of olibanum resin extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia seed oil, 2g of jojoba seed oil, 10g of wild lacquer fruit wax and 2g of rose-in seed oil.
Example 11
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 25g of caprylic/capric triglyceride, 6g of PEG-20 triisostearate, 1.3g of olibanum resin extract, 1.3g of tripeptide-1, 5g of tripeptide-1 copper, 8g of camellia seed oil, 8g of jojoba seed oil, 12g of wild lacquer fruit wax and 4g of rose-in-rust seed oil.
Example 12
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 28g of caprylic/capric triglyceride, 9g of PEG-20 triisostearate, 2g of olibanum resin extract, 1.5g of tripeptide-1, 6g of tripeptide-1 copper, 10g of camellia seed oil, 10g of jojoba seed oil, 14g of wild lacquer fruit wax and 6g of rose-in seed oil.
Example 13
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of olibanum resin extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia seed oil, 2g of jojoba seed oil, 2g of avocado oil, 3g of avocado fruit oil, 10g of wild lacquer fruit wax and 2g of rose-in seed oil.
Example 14
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 23g of caprylic/capric triglyceride, 4g of PEG-20 triisostearate, 1g of olibanum resin extract, 0.8g of tripeptide-1, 1.8g of tripeptide-1 copper, 5g of camellia seed oil, 5g of jojoba seed oil, 3g of avocado oil, 4g of avocado fruit oil, 11g of wild lacquer fruit wax and 3g of rose-in seed oil.
Example 15
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 25g of caprylic/capric triglyceride, 6g of PEG-20 triisostearate, 1g of olibanum resin extract, 0.9g of tripeptide-1, 2g of tripeptide-1 copper, 6g of camellia seed oil, 6g of jojoba seed oil, 4g of avocado oil, 6g of shea butter, 12g of wild lacquer fruit wax and 4g of rose-in oil.
Example 16
The cleaning composition which is stable and has the repairing and relieving effects in the embodiment consists of the following components: 28g of caprylic/capric triglyceride, 9g of PEG-20 triisostearate, 2g of olibanum resin extract, 1g of tripeptide-1, 6g of tripeptide-1 copper, 10g of camellia seed oil, 10g of jojoba seed oil, 6g of avocado oil, 8g of shea butter, 14g of wild lacquer fruit wax and 6g of rose-in seed oil.
The preparation method of the compositions of the above examples 1 to 16 comprises: weighing the components, and stirring and mixing uniformly at normal temperature.
The application method of any one of the compositions in examples 1 to 16 is that any one of the compositions is added into cosmetics, the composition accounts for 0.5 to 8 percent of the total mass of the cosmetics, and the cleansing skin care cosmetics such as cleansing cream, cleansing gel, bath cream and the like can be prepared according to the conventional process and auxiliary materials for preparing the cosmetics. In production, the selection and preparation process of other components in the cosmetic can be performed according to conventional operations in the art.
In order to demonstrate the effect of the present invention, comparative examples of the present invention are given below:
comparative example 1
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 23g of caprylic/capric triglyceride, 1g of olibanum resin extract, 1.8g of tripeptide-1 copper, 5g of jojoba seed oil.
Comparative example 2
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 4g PEG-20 triisostearate, 0.8g tripeptide-1, 5g camellia seed oil.
Comparative example 3
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 23g of caprylic/capric triglyceride, 1g of olibanum resin extract, 1.8g of tripeptide-1 copper, 5g of jojoba seed oil and 3g of avocado oil.
Comparative example 4
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 4g PEG-20 triisostearate, 0.8g tripeptide-1, 5g camellia seed oil, 4g butter tree fruit.
Comparative example 5
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 23g of caprylic/capric triglyceride, 1g of olibanum resin extract, 1.8g of tripeptide-1 copper, 5g of jojoba seed oil, 3g of avocado oil, 11g of wild lacquer fruit wax and 3g of rose-in seed oil.
Comparative example 6
The cleaning composition with the stability and the repairing and relieving effects of the comparative example comprises the following components: 4g of PEG-20 glycerol triisostearate, 0.8g of tripeptide-1, 5g of camellia seed oil, 4g of butter tree fruit fat, 11g of wild lacquer fruit wax and 3g of rose-in-rust seed oil.
In order to better illustrate the advantages of the present invention, the experimental results of the present invention are given below:
1. formula stability
Because the formula contains various esters such as caprylic/capric triglyceride, PEG-20 glycerol triisostearate, tripeptide-1, butter fruit tree fruit fat and the like, vegetable oil and water-soluble components, the stability of the formula is studied. The specific method comprises the following steps:
(1) Sample treatment: the compositions of examples 1 to 16 and comparative examples 1 to 6, which were just prepared, were designated as A 0 The method comprises the steps of carrying out a first treatment on the surface of the The compositions of examples 1 to 16 and comparative examples 1 to 6 were placed in an oven at 50℃for 30 days in the absence of light, and the data obtained were designated A 50 . The compositions of examples 1 to 16 and comparative examples 1 to 6 were each prepared as an aqueous solution having a mass concentration of 5%.
(2) And (3) data processing: rate of change = 1-a 0 /A 50 The results are shown in Table 1.
TABLE 1 stability test results
As can be seen from Table 1, the stability of the formulation was divided into four equal runs, examples 10-16, examples 6-9, examples 1-5 and comparative examples 1-6, respectively, with the stability being high to low. The result is due to the different components of the formulation. All examples are in a more stable state, example 16 is the highest concentration ratio of all components, and the system is the most stable at the ratio, and the stability rate reaches 95% and above. While the comparative examples 5 and 6 are clearly higher in stability than the other comparative examples due to their inclusion of the lacquer wax component, which also demonstrates the stability. However, overall, all examples were more stable than all comparative examples, sufficient to demonstrate formulation stability.
2. Repair efficacy test
The cosmetic effect of reference T/GDCA 009-2022 was tested by the transepidermal water loss test method.
(1) Test sample: the compositions of examples 1 to 16 and comparative examples 1 to 6 were prepared as 5% aqueous solutions, respectively. Meanwhile, water is used as a control group.
(2) Subject selection
The selection standard is that the age is between 18 years old and 60 years old, and healthy men or women; lactic acid stinging positive; subjective skin has one of symptoms of impaired skin barrier function, such as dryness, desquamation, redness, etc.; the test process can be understood, and the test is voluntarily participated and the informed consent person is signed; the product can be used in a proper amount according to the requirement.
Exclusion criteria are pregnant or lactating women, or those who have a pregnancy-preparing program recently; patients with skin history such as psoriasis, eczema, atopic dermatitis, etc.; currently or in the last month oral or external use of anti-inflammatory drugs such as corticosteroids; currently or in the near month to other clinical experimenters; involuntarily participating, and cannot complete the required content on time; other clinical evaluations were considered unsuitable for the participating test subjects;
withdrawal criteria are subjects such as adverse events occurring during the study or violating the study protocol, which the researcher deems unsuitable for the subject to continue to complete the study; in other cases, the clinical study is exited while the reason for the exit is written.
Safety evaluation: all adverse skin reactions such as redness, stinging, itching, burning etc. occurring during the study period should be recorded and timely reported for serious adverse reactions.
Adverse reactions were judged according to the following three-level criteria:
mild-easy to tolerate, causing little discomfort, not affecting normal life.
Moderate-enough to affect normal life.
Severe-impeding normal life.
Relationship between adverse reactions and study:
irrelevant-obviously related to other factors; unlikely-most likely to be related to other factors; may-occur after use but may also be due to other factors; it is possible-that this occurs after use but cannot be explained by other factors; it is likely-that this occurs after use, but cannot be explained by other factors, and is present after use.
The subject: the female has the advantages that the female brings 32 persons into the female, falls off 2 persons, has the effective cases of 30 persons, has 0 men and 32 women; minimum age: 18 years of age, maximum age: age 57; average age 33.09 years.
(3) Measurement procedure
For the first visit, subjects were subjected to a test instruction and signed a written informed consent. The subjects were asked a series of questions regarding disease history, health status, etc. based on inclusion and exclusion criteria, etc., and compliance assessment was performed and recorded.
Before starting the test, the test center is required to provide a face cleaning product without any efficacy for the test part of the subject to be cleaned; clean skin is detected after sitting still in a satisfactory room for at least 30 minutes. For each return visit, the elements such as cleaning products and water temperature should be kept consistent.
Skin basal values before product use were assessed and tested, including instrument testing and standard image capture and data recorded, on the qualified subjects in the group. The same test was again performed on days 7 and 14 after the use of the product.
(4) Calculation result
Descriptive statistics: descriptive statistics are performed on the measured values of each test area, including number, mean, standard deviation, minimum, median, maximum.
Differential analysis: the rates of change of the TEWL averages on the sample application side and control side were calculated separately, and then the differences between the spot application area and control area at different measurement times were statistically analyzed using the rates of change. If the test data are normally distributed, adopting a t-test method to carry out statistical analysis; if the test data are in non-normal distribution, a rank sum test method is adopted for statistical analysis. The statistical methods all use a two-tailed test with a test level α=0.05.
(5) Result determination
Positive results: compared with the control side, the change rate of the TEWL value of the sample smearing side is significantly different, and P is smaller than 0.05, so that the tested sample has an effect of promoting the recovery of the transepidermal water loss of the barrier damaged skin.
Negative results: compared with the control side, the change rate of the TEWL value of the sample smearing side is not significantly different by more than 0.05, which indicates that the tested sample has no promoting effect on the recovery of the transepidermal water loss of the barrier damaged skin.
TABLE 2 TEWL value for the percutaneous Water loss of test samples at various times
The results of the experiment in Table 2 were statistically analyzed, and the comparative examples and examples were all reparative to different extents, but the rate of change of the TEWL value of the transepidermal water loss was much higher for all the examples of the experimental group than for all the comparative examples of the experimental group. Example 16 showed a 11% decrease in the trans-epidermal water loss value after 7 days of use, compared to before the sample, with a very significant difference, indicating that the composition had a repair effect after 7 days of use. While the comparative examples of the experimental groups had a certain reduction rate, the reduction degree did not have a significant difference. The control group data also show that the repairing effect is almost not found, and the repairing effect of all the examples of the experimental group is better than that of the comparative example, so that the repairing effect is greatly enhanced by the synergistic combination of various substances in the composition.
3. Test of soothing efficacy
The method is carried out by referring to the clinical evaluation standard method of the T/CNMIA 0015-2020 sensitivity-relieving functional skin care product.
1. Lactic acid stinging test
(1) Test sample: the compositions of examples 1 to 16, comparative examples 1 to 6 were added to a conventional emulsion external-use matrix to prepare test samples, in which a stable cleaning composition having a repairing and soothing effect accounted for 5% of the total mass of the emulsion.
(2) The testing method comprises the following steps: lactic acid stinging sensitive muscle screening: 50 μl of 10% lactic acid solution was dropped on a filter paper with a diameter of 8mm, placed in the nasal labial sulcus of both sides of the subject, and the degree of discomfort of itching, tingling, burning pain of the test site was evaluated by the subject at 30S, 2.5min and 5min, respectively. Scoring was performed by a score of 4 (no sensation at 0, mild at 1, moderate at 2, and heavy at 3). And the sum of the stinging scores of 2.5min and 5min is more than or equal to 3, and the stinging scores are positive to the lactic acid stinging. Subjects were equally divided into 22 groups (5 persons each) based on the lactic acid stinging screening results, each group being smeared with a different test sample. The test product was used 1 time a day in the morning and evening during the run of the cumulative trial. And the lactic acid stinging screening score is taken as a basic value, the lactic acid stinging test is carried out again after the product is used for 28 days, the SPSS is utilized to carry out statistical analysis on the lactic acid stinging score before and after the product is used, and the difference of P <0.05 is statistically significant.
TABLE 3 lactic acid stinging scores of test samples at various times
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As can be seen from the experimental results in table 3, examples 1 to 16 achieve the expected effect, can slow down the stimulation of lactic acid to skin, and through Wilcoxon pairing rank sum test, the test level α=0.05, p <0.001 is obtained, which indicates that the lactic acid stinging score of the subjects who continuously use the test samples of examples 1 to 16 for 28 days has a significant difference from the base value, and the stinging degree is greatly reduced; while the comparative examples 1 to 6 were improved over the prior art, the expected effect was not achieved, and the effect was only half that of the examples, indicating that the comparative examples may still be sensitive to a small proportion.
2. Hyaluronidase inhibition assay
Hyaluronidase is hydrolase for degrading hyaluronic acid, is a main component of extracellular matrix of connective tissue of an organism and is related to most allergic reactions, so that the in vitro inhibition experiment of the hyaluronidase can reflect the effects of products on relieving skin, resisting allergy, resisting inflammation and the like to a certain extent; hyaluronic acid is a higher polysaccharide composed of D-glucuronic acid and N-acetylglucosamine, and can undergo a color reaction according to the Elson-morgan reaction. The inhibition rate of the hyaluronidase of the sample can be determined by the reaction; the larger the inhibition rate is, the better the soothing, anti-sensitization or sensitization inhibition effect is.
(1) Test sample: the test samples were the samples of examples 1 to 16 and comparative examples 1 to 6, and the concentrations were 0.5%, 4% and 8%, respectively.
(2) The testing method comprises the following steps: the test was performed according to ELSON-MORGAN improvement.
Table 4 samples were assayed for hyaluronidase inhibition at various concentrations (unit:%)
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As can be seen from the experimental results of Table 4, the results of the hyaluronidase inhibition rates of examples 1 to 16 are significantly higher than those of comparative examples 1 to 6, indicating that the soothing, antiallergic or sensitization inhibition effects of examples 1 to 16 are better than those of comparative examples 1 to 6. Although the groups of comparative examples 1 to 6 also had a certain effect of relieving allergy, the effect of relieving was not remarkable, and far from the examples, the highest inhibition ratio of comparative example was 9.48% at 8% concentration, and the difference of example was 75.17%, which was almost 8-fold. The synergistic effect of the components and the content of the components is obvious and obvious.
3. Visia image analysis method
(1) Test sample: the compositions of examples 1 to 16, comparative examples 1 to 6 were added to a conventional emulsion external-use matrix to prepare test samples, in which a stable cleaning composition having a repairing and soothing effect accounted for 5% of the total mass of the emulsion.
(2) Subject selection: subjects with lactic acid stinging pain
(3) Measurement procedure
The visual photographs of D0 before using the sample were taken first, and then the visual photographs of D7 and D14 were taken at 7 and 14 days, respectively. The visual facial red area picture was analyzed using Image-Pro Plus 7.0C to yield red area a values as shown in Table 5.
Table 5 test samples for facial red area a values at different times
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Statistical analysis of the experimental results of table 5, comparing the a values of examples 1-16 with 0 days for 7 days, 14 days, was significantly reduced with significant differences, P <0.001. The compositions of examples 1 to 16 are shown to have an effect of promoting recovery of facial inflammation. The recovery effect of comparative examples 1 to 6 on inflammation was not obvious, and the recovery effect of examples 1 to 16 on facial inflammation was significantly better than that of comparative examples 1 to 6, and the red area a value was reduced by 13% after 7 days of use of example 16 compared with that before the use of the sample, with a very significant difference, the sample had an obvious effect of relieving facial redness after 7 days of use, and the reduction rate had been reduced to 12.85 on day 14, and reached 34%. The effective relieving ability of the traditional Chinese medicine composition is proved, and the importance and the necessity of the synergistic effect of the components in solving the problem of skin inflammation are further demonstrated.
In summary, the invention is through the mutual cooperation and synergistic effect among several substances of caprylic acid/capric triglyceride, PEG-20 triglyceride triisostearate, olibanum resin extract, tripeptide-1 copper, camellia seed oil, jojoba seed oil, avocado oil, butter tree fruit fat, wild lacquer fruit wax and red rose seed oil, it can be seen from the results of the combination stability test, the maintenance efficacy test and the relief efficacy test that in the stability test, although the examples and the comparative examples are relatively stable, the stability of the examples is superior to that of the comparative examples; in the test of repairing efficacy and relieving efficacy, the effect of the composition is obviously better than that of the comparative example, the comparative example can be sensitive in a smaller proportion, and the effect of the example is enhanced by 8-10 times compared with the comparative example, so that the composition has obvious repairing and relieving effects.
Claims (1)
1. The stable cleaning composition with the repairing and relieving effects is characterized by being prepared from the following components in parts by weight: 16-22 parts of caprylic/capric triglyceride, 3-7 parts of PEG-20 triisostearate, 3-6 parts of frankincense resin extract, 3-6 parts of tripeptide-1 copper, 3-7 parts of camellia seed oil, 3-7 parts of jojoba seed oil, 2-8 parts of avocado oil, 9-13 parts of shea butter, 5-15 parts of wild lacquer fruit wax and 2-8 parts of rose-in seed oil.
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| Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity;Heba A. Gad等;《Polymers (Basel)》;第13卷(第11期);1711 * |
| 汝新美肌蓝铜胜肽修护卸妆膏;陕西慧康生物科技有限责任公司;《国产普通化妆品备案信息平台，https://hzpba.nmpa.gov.cn/gccx/》》;第1页 * |
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