CN112933024A - Repair face cream containing industrial hemp extract and preparation method thereof - Google Patents
Repair face cream containing industrial hemp extract and preparation method thereof Download PDFInfo
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- CN112933024A CN112933024A CN202110417300.XA CN202110417300A CN112933024A CN 112933024 A CN112933024 A CN 112933024A CN 202110417300 A CN202110417300 A CN 202110417300A CN 112933024 A CN112933024 A CN 112933024A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to the technical field of daily chemical articles, and particularly relates to a repair face cream containing an industrial hemp extract, which comprises the following raw materials in parts by weight: water, nicotinamide, allantoin, carboxymethyl deacetylated fructose, water-glycerol glucoside-glycerol solution, butylene glycol, carbomer and p-hydroxyacetophenone, phase B raw materials: cetearyl-cetearyl glucoside solution, cetearyl olive oleate-sorbitan olive oleate solution, hydrogenated polyisobutene, isononyl isononanoate, polydimethylsiloxane and tocopheryl acetate, phase C starting material: arginine, phase D raw material: 1, 2-hexanediol, panthenol, inositol, centella asiatica extract, and industrial cannabis extract; the industrial hemp extract and other raw materials act together to realize synergistic interaction, so that the effects of moisturizing, oxidation resistance, inflammation resistance, repair, glossiness improvement and the like of the face cream can be improved, and the face cream has no stimulation to skin; the raw materials are easy to obtain, the compatibility is scientific and reasonable, the preparation method is simple, the use is convenient, and the market prospect is wide.
Description
The technical field is as follows:
the invention belongs to the technical field of daily chemical articles, and particularly relates to a repair cream containing an industrial hemp extract and a preparation method thereof.
Technical background:
in recent years, as the disposable income of people is gradually increased, the requirements of people on self are higher and higher, such as compact and uniform body and smooth and fine skin, but the skin of the facial part is much more tender than other parts of the body, and the tolerance is also poor. The cream is the most important step of basic skin care, and has the functions of locking water, keeping moisture, improving the texture of the surface layer of skin, smoothening the skin color and enhancing the skin resistance. The cream with various efficacies on the market, for example, Chinese patent CN201310100567.1 discloses a traditional Chinese medicine acne-removing cream which consists of active ingredients of traditional Chinese medicines and a carrier, wherein the active ingredients of the traditional Chinese medicines are prepared by 19 traditional Chinese medicines and extracts of 3 fruits; the carrier is prepared by mixing 8 high molecular compounds, honey, essence and distilled water; wherein the effective components of the traditional Chinese medicine account for 4-8% of the weight of the face cream; the carrier accounts for 92-96% of the weight of the cream. Because the cream is prepared from the active ingredients extracted from 19 traditional Chinese medicines and 3 fruit raw materials and a carrier consisting of 8 macromolecular compounds, honey, essence and water, the cream has good acne removing effect, no toxic or side effect, convenient production and use and is beneficial to keeping the beautiful image of facial skin; chinese patent CN201410219028.4 discloses an anti-aging cream containing Ganoderma lucidum, which comprises component A accounting for 0.02-5% of the cream by mass and component B accounting for 0.02-5% of the cream by mass; component A, namely the anti-aging active component of the ganoderma aqueous extract; component B, i.e. Ganoderma CO2Supercritical extracting anti-aging active ingredient, emulsifying component A and component B at high temperature according to a certain ratio, and heating at high temperatureAdding base material to obtain face cream; chinese patent CN201810921905.0 discloses a moringa oleifera freckle-removing and whitening cream which comprises the following components in parts by weight: 1-10 parts of moringa total flavone extract, 0.05-1 part of litsea cubeba oil, 0.1-2 parts of olive oil and 1-5 parts of rose essential oil; the preparation method comprises the following steps: putting carbomer, glycerol and water in a container, shaking and mixing thoroughly, heating to swell, standing overnight, adding Tween 80, stirring until Tween 80 is uniformly dispersed, then sequentially adding 70% sorbitol solution, water, Moringa oleifera total flavone extract, poloxamer, ethylparaben, Litsea cubeba oil, olive oil, rose essential oil and triethanolamine, adjusting pH to 6.0, and stirring to form gel to obtain Moringa oleifera total flavone facial cream. The existing face cream has a plurality of types, but most of the face creams have single functions, and the functions of effectively and quickly relieving itching and eliminating redness, continuously diminishing inflammation and resisting acne, strongly stroking marks and fading marks and the like are lacked, so that the development of a multifunctional face cream is very necessary.
The invention content is as follows:
in order to overcome the defects of the prior art, the invention provides the repair face cream containing the industrial hemp extract and the preparation method thereof.
In order to achieve the purpose, the invention provides a repair cream containing industrial hemp extract, which comprises the following raw materials in parts by weight: 50-60 parts of water, 1-5 parts of nicotinamide, 0.1-0.6 part of allantoin, 0.2-0.8 part of carboxymethyl deacetylated fructose, 1-10 parts of water-glycerol glucoside-glycerol solution, 1-10 parts of butanediol, 0.1-0.5 part of carbomer and 0.2-1 part of p-hydroxyacetophenone, and the B phase raw material comprises the following components in parts by weight: 1-10 parts of cetearyl alcohol-cetearyl glucoside solution, 1-5 parts of cetearyl olive oleate-sorbitan olive oleate solution, 1-5 parts of hydrogenated polyisobutene, 2-8 parts of isononyl isononanoate, 1-5 parts of polydimethylsiloxane and 0.2-2 parts of tocopherol acetate, and phase C raw materials: 0.1-0.5 part of arginine, and the phase D raw materials: 0.2-1 part of 1, 2-hexanediol, 1-5 parts of panthenol, 1-5 parts of inositol, 0.5-2 parts of centella asiatica extract and 0.5-2 parts of industrial hemp extract.
The CBD content in the industrial hemp extract is 50-60%.
The water-glycerol glucoside-glycerol solution consists of water, glycerol glucoside and glycerol in a mass ratio of 1-3:2-4: 3-5.
The cetearyl alcohol-cetearyl glucoside solution is prepared by mixing cetearyl alcohol and cetearyl glucoside in a mass ratio of 1-3: 1-4.
The cetearyl alcohol olive oleate-sorbitan olive oleate solution is prepared by mixing cetearyl alcohol olive oleate and sorbitan olive oleate according to the mass ratio of 1-2: 1-3.
The preparation method of the repair cream containing the industrial hemp extract comprises the following specific steps:
(1) equipment disinfection: cleaning and disinfecting the vacuum emulsifying pot, the weighing device and all used equipment according to the cleaning and disinfecting process specified by the installation for standby;
(2) weighing raw materials: weighing phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials in parts;
(3) adding phase A raw materials: putting the phase A raw material into a vacuum emulsifying pot, uniformly stirring, heating to 80-90 ℃, and then homogenizing at a homogenizing speed of 3000r/min for 3-8 minutes until the material body is dissolved uniformly and transparently to form a semitransparent viscous liquid;
(4) adding a phase B raw material: adding the phase B raw material into a stirring tank, heating to 70-90 ℃, uniformly stirring at a stirring speed of 10-30r/min until no particles are completely dissolved, namely yellowish to colorless liquid, quickly and vacuum pumping the dissolved phase B into a vacuum emulsifying pot, homogenizing the vacuum emulsifying pot at a homogenizing speed of 3000r/min at 80-90 ℃ for 3-8min after pumping, and completely and uniformly mixing the material in the vacuum emulsifying pot, wherein the material is a thick liquid which is yellowish white to white; then keeping the temperature at 80-90 ℃ at the stirring speed of 10-30r/min and stirring for 10-30 min;
(5) adding a phase C raw material: cooling to 55-75 deg.C, adding C phase raw material, homogenizing at 55-75 deg.C and 3000r/min for 1-3 min until the material body becomes uniform thick paste;
(6) adding a D-phase raw material: cooling to 40-60 deg.C, adding D phase raw material, homogenizing at 3000r/min for 1-5min until the paste is completely uniform;
(7) discharging: cooling to 38 ℃, taking the materials for inspection, and discharging after the materials are qualified;
(8) product filling: and standing the material body for 5 days, pouring the material body into a filling machine for filling after the micro-inspection is qualified, and completing the preparation of the repair cream containing the industrial hemp extract.
In the step (3), the stirring speed of the phase A raw material is 20-40r/min, and the heating speed is 1 ℃/min; in the step (4), the temperature rising speed of the phase B raw material in the stirring tank is 1 ℃/min.
The cooling speed of the step (5) and the cooling speed of the step (6) are both 1 ℃/min.
Compared with the prior art, the industrial hemp extract has multiple effects of oxidation resistance, inflammation resistance, bacteria resistance, aging resistance, acne removal and the like, can obviously reduce facial grease secretion, and can reduce and repair erythema after solarization; the industrial hemp extract and other raw materials act together to realize synergistic interaction, so that the effects of moisturizing, oxidation resistance, inflammation resistance, repair, glossiness improvement and the like of the face cream can be improved, and the face cream has no stimulation to skin; the raw materials are easy to obtain, the compatibility is scientific and reasonable, the preparation method is simple, the use is convenient, and the market prospect is wide.
The specific implementation mode is as follows:
the invention is further illustrated by the following specific examples.
Example 1:
the raw materials of the repair cream containing the industrial hemp extract comprise a phase A raw material, a phase B raw material, a phase C raw material and a phase D raw material, wherein the phase A raw material comprises 57.6 parts by weight of water, 2 parts by weight of nicotinamide, 0.2 part by weight of allantoin, 0.6 part by weight of carboxymethyl deacetylated polyfructose, 5 parts by weight of water-glycerol glucoside-glycerol, 7 parts by weight of butanediol, 0.35 part by weight of carbomer and 0.5 part by weight of p-hydroxyacetophenone, the phase B raw material comprises 2.5 parts by weight of cetearyl-cetearyl glucoside, 3 parts by weight of cetearyl-olivetoleate, 5 parts by weight of hydrogenated polyisobutene, 5 parts by weight of isononyl isononanoate, 2 parts by weight of polydimethylsiloxane and 0.5 part by weight of tocopheryl acetate, the phase C raw material comprises 0.2 part by weight of arginine, and the phase D raw material comprises 0.6 part by weight of 1, 2-hexanediol, 0.6 part by weight of, 1 part of panthenol, 1 part of inositol, 0.95 part of centella asiatica extract and 1 part of industrial hemp extract.
The water-glycerol glucoside-glycerol solution consists of water, glycerol glucoside and glycerol in a mass ratio of 1:2: 3.
The cetearyl alcohol-cetearyl glucoside solution is prepared by mixing cetearyl alcohol and cetearyl glucoside in a mass ratio of 1: 1.
The cetearyl alcohol olive oleate-sorbitan olive oleate solution is prepared by mixing cetearyl alcohol olive oleate and sorbitan olive oleate according to the mass ratio of 1: 1.
The butanediol and the 1, 2-hexanediol related to the embodiment are used as a humectant and a solvent, so that the smoothness of the product can be improved.
The polydimethylsiloxane according to the present example can impart flexibility to the skin as an emollient agent or an anti-blocking agent.
The panthenol of the present example acts as a moisturizer, and can improve hydration, reduce itching and inflammation of the skin, improve skin elasticity, and accelerate the healing rate of epidermal wounds.
The inositol related to the embodiment is used as a moisturizing agent and a skin conditioning agent, has a nourishing effect on the skin, and can increase the glossiness of the skin.
The p-hydroxyacetophenone related to the embodiment can be used as an antioxidant and an antiseptic accelerator, and can effectively prevent the product from deteriorating.
The tocopherol acetate related to the embodiment is used as an antioxidant of skin cells, has a certain anti-aging effect, promotes wound healing, and prevents skin from being lack of water and aging.
The asiatic centella (CENTELLA ASIATICA) extract is used as a nutritional repairing agent, can promote the synthesis of collagen, mainly the synthesis of type I collagen and type III collagen, can inhibit various inflammatory factors, and can improve and repair the barrier function of skin.
The niacinamide related to the embodiment has good effect and effect on skin, can promote metabolism of the skin, remove impurities in the skin, enable the skin to be more glossy, is particularly obvious for removing some melanin, increases the rapid exfoliation of black cell cutin, promotes the excitation of the activity of some decayed cells, promotes the synthesis of some collagen, can inhibit the generation of the melanin to a certain extent, does not generate the accumulation of the melanin, and has good whitening effect on the skin; can also reduce pores, achieve the effect of removing acnes, and has certain inhibiting effect on fatty acids secreted in the skin so as to gradually reduce the fatty acids.
The allantoin used as the skin conditioner in the embodiment is an amphoteric compound, can be combined with various substances to form a double salt, has the effects of shading, sterilizing, preventing corrosion, relieving pain and resisting oxidation, and can keep the skin moist, moist and soft.
The carboxymethyl chitosan related to the embodiment is used as a film forming agent and a gel agent, promotes to form a hydrated film, keeps the moisture retention effect on the stratum corneum and prevents the skin from drying.
The CANNABIS SATIVA (CANNABIS SATIVA) leaf extract as a skin conditioner mainly contains Cannabidiol (CBD), the CBD content is 50% -60%, physiological dependence cannot be caused, the CANNABIS SATIVA (CANNABIS SATIVA) leaf extract has good tolerance, the CANNABIS SATIVA leaf extract has good effects on neurological diseases, inflammation, pain and the like, and the CANNABIS SATIVA (CANNABIS SATIVA) leaf extract has multiple effects of oxidation resistance, inflammation resistance, bacteria resistance, ageing resistance, acne removal and the like in cosmetics, can obviously reduce facial grease secretion, and can reduce and repair erythema after sunburn.
The hydrogenated polyisobutene according to this example, as a film former, emollient and viscosity controller, has the cosmetic properties of squalane, and is therefore called synthetic squalane, and is able to control the viscosity of the cream and promote better film formation of the cream.
The isononyl isononanoate referred to in this example is an emollient with a silky feel, a dry and extremely soft hand due to its unique multi-methyl branched chain structure, excellent emollient. The silicone oil stabilizer and the coupling agent have good intermiscibility with polydimethylsiloxane, can solve the problem of low-temperature precipitation of silicone oil.
The cetearyl olive oleate, the cetearyl alcohol and the cetearyl alcohol related to the embodiment are used as the emulsifying agents, so that the skin can be moistened, a liquid crystal film is formed on the surface layer of the skin, and the long-term water retention of the skin is improved.
The carbomer related to the embodiment is used as a thickening agent and a stabilizing agent, can promote moisture retention, and plays a role in stabilizing products.
The arginine as a pH regulator and a humectant can regulate the pH of the cream, and can also be used for conditioning dry skin, keeping skin moisture, smoothing skin and reducing desquamation of dandruff.
The preparation method of the repair cream containing the industrial hemp extract, which is related by the embodiment, comprises the following specific process steps:
(1) equipment disinfection: cleaning and disinfecting the vacuum emulsifying pot, the weighing device and all used equipment according to the cleaning and disinfecting process specified by the installation for standby;
(2) weighing raw materials: weighing phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials in parts by weight, wherein the specific steps are as follows: the phase A comprises the following raw materials: 57.6 parts of water, 2 parts of nicotinamide, 0.2 part of allantoin, 0.6 part of carboxymethyl deacetylated fructose, 5 parts of water-glycerol glucoside-glycerol, 7 parts of butanediol, 0.35 part of carbomer and 0.5 part of p-hydroxyacetophenone; the phase B comprises the following raw materials: 6.5 parts of cetearyl-cetearyl glucoside, 3 parts of cetearyl olive oleate-sorbitan olive oleate, 5 parts of hydrogenated polyisobutene, 5 parts of isononyl isononanoate, 2 parts of polydimethylsiloxane and 0.5 part of tocopherol acetate; the phase C raw materials are as follows: 0.2 part of arginine; the phase D comprises the following raw materials: 0.6 part of 1, 2-hexanediol, 1 part of panthenol, 1 part of inositol, 0.95 part of centella asiatica extract and 1 part of industrial hemp extract;
(3) adding phase A raw materials: putting the phase A raw material into a vacuum emulsifying pot, uniformly stirring at a stirring speed of 20r/min, heating to 80 ℃ at a heating speed of 1 ℃/min, and homogenizing at a homogenizing speed of 3000r/min for 3 minutes until the material body is dissolved to be uniform and transparent to semitransparent viscous liquid;
(4) adding a phase B raw material: adding the phase B raw material into a stirring tank (heating to 75 ℃ according to the speed of 1 ℃/min), stirring uniformly at the stirring speed of 25r/min until no particles are dissolved completely, pumping the dissolved phase B into a vacuum emulsifying pot which is kept at 80 ℃ in a rapid vacuum manner, homogenizing for 3min at the homogenization speed of 3000r/min at 80 ℃ after pumping, until the material in the vacuum emulsifying pot is completely mixed uniformly, and then the material is a thick liquid which is slightly yellowish white to white; then stirring for 25min at the stirring speed of 25r/min and the temperature of 80 ℃;
(5) adding a phase C raw material: then cooling to 60 ℃ according to the cooling speed of 1 ℃/min, adding a C-phase raw material, homogenizing for 1 minute at the homogenization speed of 3000r/min at 60 ℃, until the material body becomes a uniform and thick paste;
(6) adding a D-phase raw material: then cooling to 45 ℃ according to the cooling speed of 1 ℃/min, adding the D-phase raw material, and homogenizing at the homogenizing speed of 3000r/min for 1 minute until the paste is completely uniform;
(7) discharging: cooling to 38 ℃ at a cooling rate of 1 ℃/min, taking the materials, inspecting, and discharging after the materials are qualified; detecting whether the appearance, state, color and consistency of the discharged material meet the standards; the detection standard is as follows: light brown paste, 5.0< ph <7.0, viscosity: 4 #; 6r, 5.5-6.5 kilo pa.m/s; carrying out microorganism detection after standing for 24 hours;
(8) product filling: and (4) after the material body is kept stand (for 5 days) and is qualified through micro inspection, pouring the material body into a filling machine for filling, and completing the preparation of the repair cream containing the industrial hemp extract. The method (4) is also used for detecting again after filling.
In this example, the quality of a repair cream containing an extract of industrial cannabis sativa was checked according to technical and safety regulations on cosmetics (2015 edition) issued by the State food and drug administration. The results of the measurements are shown in tables 1 and 2.
TABLE 1 sanitary chemistry test results
TABLE 2 results of microbial detection
Example 2:
the raw materials of the repair cream containing the industrial hemp extract comprise an A-phase raw material, a B-phase raw material, a C-phase raw material and a D-phase raw material, wherein the A-phase raw material comprises, by weight, 61.6 parts of water, 1 part of nicotinamide, 0.3 part of allantoin, 0.2 part of carboxymethyl deacetylate fructose, 3 parts of water-glycerol glucoside-glycerol, 10 parts of butanediol, 0.5 part of carbomer and 0.8 part of p-hydroxyacetophenone; the phase B comprises the following raw materials: 4 parts of cetearyl-cetearyl glucoside, 2 parts of cetearyl olive oleate-sorbitan olive oleate, 3 parts of hydrogenated polyisobutene, 5 parts of isononyl isononanoate, 1 part of polydimethylsiloxane and 0.3 part of tocopherol acetate; the phase C raw materials are as follows: 0.3 part of arginine; the phase D comprises the following raw materials: 0.5 part of 1, 2-hexanediol, 2 parts of panthenol, 1.5 parts of inositol, 1 part of centella asiatica extract and 2 parts of industrial hemp extract.
The water-glycerol glucoside-glycerol solution consists of water, glycerol glucoside and glycerol in a mass ratio of 2:3: 3.
The cetearyl alcohol-cetearyl glucoside solution is prepared by mixing cetearyl alcohol and cetearyl glucoside in a mass ratio of 2:3, and (3).
The cetearyl alcohol olive oleate-sorbitan olive oleate solution is prepared by mixing cetearyl alcohol olive oleate and sorbitan olive oleate according to the mass ratio of 1: 2.
The preparation method of the repair cream containing the industrial hemp extract, which is related by the embodiment, comprises the following specific steps:
(1) equipment disinfection: cleaning and disinfecting the vacuum emulsifying pot, the weighing device and all used equipment according to the cleaning and disinfecting process specified by the installation for standby;
(2) weighing raw materials: weighing phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials in parts;
(3) adding phase A raw materials: putting the phase A raw material into a vacuum emulsifying pot, uniformly stirring at a stirring speed of 30r/min, heating to 85 ℃ at a heating speed of 1 ℃/min, and homogenizing at a homogenizing speed of 3000r/min for 5 minutes until the material body is dissolved to be uniform and transparent to semitransparent viscous liquid;
(4) adding a phase B raw material: adding the phase B raw material into a stirring tank (heating to 80 ℃ at the speed of 1 ℃/min), stirring uniformly at the stirring speed of 20r/min until no particles are dissolved completely, pumping the dissolved phase B into a vacuum emulsifying pot which is kept at 85 ℃ in a rapid vacuum manner, homogenizing for 5min at the homogenization speed of 3000r/min at 85 ℃ after pumping, until the material in the vacuum emulsifying pot is completely mixed uniformly, and then the material is a thick liquid which is slightly yellowish white to white; then stirring for 20min at the stirring speed of 20r/min and the temperature of 85 ℃;
(5) adding a phase C raw material: then cooling to 65 ℃ according to the cooling speed of 1 ℃/min, adding the C-phase raw material, homogenizing for 2 minutes at 65 ℃ and the homogenizing speed of 3000r/min until the material body becomes a uniform and thick paste;
(6) adding a D-phase raw material: then cooling to 50 ℃ according to the cooling speed of 1 ℃/min, adding the D-phase raw material, homogenizing at the homogenizing speed of 3000r/min for 2 minutes until the paste is completely uniform;
(7) discharging: cooling to 38 ℃ at a cooling rate of 1 ℃/min, taking the materials, inspecting, and discharging after the materials are qualified; detecting whether the appearance, state, color and consistency of the discharged material meet the standards; the detection standard is as follows: light brown paste, 5.0< ph <7.0, viscosity: 4 #; 6r, 5.5-6.5 kilo pa.m/s; carrying out microorganism detection after standing for 24 hours;
(8) product filling: and (4) after the material body is kept stand (for 5 days) and is qualified through micro inspection, pouring the material body into a filling machine for filling, and completing the preparation of the repair cream containing the industrial hemp extract. The method (4) is also used for detecting again after filling.
Example 3:
the raw materials of the repair cream containing the industrial hemp extract comprise phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials, wherein the phase A raw materials comprise 52.1 parts of water, 5 parts of nicotinamide, 0.6 part of allantoin, 0.8 part of carboxymethyl deacetylated fructose, 2 parts of water-glycerol glucoside-glycerol, 6 parts of butanediol, 0.2 part of carbomer and 0.2 part of p-hydroxyacetophenone by weight; the phase B comprises the following raw materials: 8 parts of cetearyl-cetearyl glucoside, 8 parts of cetearyl olive oleate-sorbitan olive oleate, 1 part of hydrogenated polyisobutene, 1 part of isononyl isononanoate, 2 parts of polydimethylsiloxane and 1.5 parts of tocopherol acetate; the phase C raw materials are as follows: 0.1 part of arginine; the phase D comprises the following raw materials: 1 part of 1, 2-hexanediol, 5 parts of panthenol, 3 parts of inositol, 2 parts of centella asiatica extract and 0.5 part of industrial hemp extract.
The water-glycerol glucoside-glycerol solution consists of water, glycerol glucoside and glycerol in a mass ratio of 3:4: 5.
The cetearyl alcohol-cetearyl glucoside solution is prepared by mixing cetearyl alcohol and cetearyl glucoside in a mass ratio of 3: 4.
The cetearyl alcohol olive oleate-sorbitan olive oleate solution is prepared by mixing cetearyl alcohol olive oleate and sorbitan olive oleate according to the mass ratio of 2:3, and (3).
The preparation method of the repair cream containing the industrial hemp extract, which is related by the embodiment, comprises the following specific steps:
(1) equipment disinfection: cleaning and disinfecting the vacuum emulsifying pot, the weighing device and all used equipment according to the cleaning and disinfecting process specified by the installation for standby;
(2) weighing raw materials: weighing phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials in parts;
(3) adding phase A raw materials: putting the phase A raw material into a vacuum emulsifying pot, uniformly stirring at a stirring speed of 30r/min, heating to 85 ℃ at a heating speed of 1 ℃/min, and homogenizing at a homogenizing speed of 3000r/min for 5 minutes until the material body is dissolved to be uniform and transparent to semitransparent viscous liquid;
(4) adding a phase B raw material: adding the phase B raw material into a stirring tank (heating to 80 ℃ at the speed of 1 ℃/min), stirring uniformly at the stirring speed of 20r/min until no particles are completely dissolved, and then quickly and vacuum pumping the dissolved phase B into a vacuum emulsifying pot which is kept at 85 ℃, homogenizing for 5min at the homogenization speed of 3000r/min at 85 ℃ after pumping, until the material in the vacuum emulsifying pot is completely and uniformly mixed, wherein the material is a thick liquid which is slightly yellowish white to white; then stirring for 20min at the stirring speed of 20r/min and the temperature of 85 ℃;
(5) adding a phase C raw material: then cooling to 65 ℃ according to the cooling speed of 1 ℃/min, adding the C-phase raw material, and homogenizing for 2 minutes at the temperature of 65 ℃ and the homogenization speed of 3000r/min until the material body becomes a uniform and thick paste;
(6) adding a D-phase raw material: then cooling to 50 ℃ according to the cooling speed of 1 ℃/min, adding the D-phase raw material, homogenizing at the homogenizing speed of 3000r/min for 2 minutes until the paste is completely uniform;
(7) discharging: cooling to 38 ℃ at a cooling rate of 1 ℃/min, taking the materials, inspecting, and discharging after the materials are qualified; detecting whether the appearance, state, color and consistency of the discharged material meet the standards; the detection standard is as follows: light brown paste, 5.0< ph <7.0, viscosity: 4 #; 6r, 5.5-6.5 kilo pa.m/s; carrying out microorganism detection after standing for 24 hours;
(8) product filling: and (4) after the material body is kept stand (for 5 days) and is qualified through micro inspection, pouring the material body into a filling machine for filling, and completing the preparation of the repair cream containing the industrial hemp extract. The method (4) is also used for detecting again after filling.
Example 4:
this example is a test for the effect of the repair cream containing the extract of industrial hemp prepared in example 1, which was conducted by the research center for genetic drug engineering, Guangdong and Dacron GmbH.
1. Test subject
The face skin is mixed or oily, and has problems of acne, pimple, etc. in 30 healthy Chinese male and female subjects, the age is 18-45 years, and the average age is 30.0 + -8.7 years. Of these, 3 were withdrawn halfway, and 27 were actually 30.1. + -. 8.9 years old.
2. Test method
2.1 test instruments:
skin moisture test probe (Germany C & K, Corneometer CM825)
Skin water loss tester (Germany C & K, Tewameter TM300)
Skin oil tester (Germany C & K, Sebumeter SM815)
Skin gloss test probe (Skin-Glossimeter GL200)
Skin pH tester (Skin-pH-Meter PH905)
IPP Image analysis software (Image pro plus)
Spectrophotometer (MinlIta CM2600)
Face image analyzer (VISIA-CR)
Electronic balance (Sartorius CP224S)
2.2 data characterisation:
water content of horny layer: the larger the measured value of the water content of the stratum corneum of the skin is, the higher the water content of the stratum corneum of the skin is.
Skin transdermal water loss rate (TEWL): the lower the skin transdermal loss rate, the better the skin barrier.
Skin oil and fat: reflecting the index of skin oil secretion, the larger the measured value, the more oily the skin.
Skin glossiness: reflecting the skin's shine index, the greater the measured value, the better the skin's shine.
Skin pores account for: the skin measurement area has pore proportion, and the smaller the proportion is, the smaller the pore is.
L value: reflecting the skin brightness, the greater the measured value, the brighter the skin.
a value: reflecting the redness of the skin, the greater the measured value, the more red the skin.
Skin PH: reflecting the pH value of the skin, the range of normal healthy skin is 5.5-7.0.
2.3 test methods:
subjects applied the treatment cream containing the extract of industrial cannabis on their faces for 14 consecutive days, and one side was randomly selected as the test area and the treatment cream was used. Testing the moisture content of the stratum corneum before trial (D0), 4 hours after trial (4H), 8 hours after trial (8H), 7 days after trial (D07) and 14 days after trial (D14), respectively; skin moisture loss through skin, skin PH, skin oil, skin gloss, skin L, pox a before trial (D0), after trial 8 hours (8H), after trial 7 days (D07) and after trial 14 days (D14); after VISIA-CR photographing, facial pore ratios were randomly analyzed using IPP image analysis software, and whether there was a statistical difference before and after using the product was compared.
The test observation doctor evaluates the facial skin pox and pox mark, and the evaluation indexes are as follows: "significantly improved", "no improvement" and "worsened". An evaluation of "significant improvement" and "improvement" is considered effective, and an evaluation of "no improvement" and "deterioration" is considered ineffective.
3. Test results
3.1 test results of Water content of stratum corneum
The results of the stratum corneum moisture test are shown in table 3.1.
TABLE 3.1 test results for stratum corneum moisture content
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.1, the moisture content of the stratum corneum of the facial skin increased 27.2% at 4H, 27.7% at 8H, 18% at D07, 32% at D14 compared to pre-trial (D0), with significant differences at 4H, 8H, D07, and D14 compared to pre-trial, suggesting that the product had skin moisturizing efficacy after 14 days of use and had skin moisturizing efficacy already at the start of 4H.
3.2 transdermal Water loss Rate test results
The results of the transdermal water loss rate test are shown in table 3.2.
TABLE 3.2 test results for transdermal Water loss Rate
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.2, the facial skin transdermal water loss rate was reduced by 15.2% at 8H, 9.0% at D07, and 14.6% at D14, as compared to pre-trial (D0), with a significant difference between both 8H, D07 and D14, suggesting that the product had improved skin barrier efficacy after 14 days of use, and had already improved skin barrier efficacy beginning at 8H.
3.3 skin oil test results
The results of the skin oil test are shown in table 3.3.
TABLE 3.3 skin oil test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.3, facial skin oil was reduced by 0.5% at 8H, by 8.6% at D07, and by 9.4% at D14, as compared to before trial (D0), with a significant difference between D07 and D14, suggesting that the product had efficacy in improving skin oil secretion after 14 days of use, and had efficacy in improving skin oil secretion already beginning at day 07.
3.4 skin gloss test results
The skin gloss test results are shown in table 3.4.
TABLE 3.4 skin gloss test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.4, the facial skin gloss increased 32.7% at 8H, 16.5% at D07, 31.9% at D14 compared to pre-trial (D0), with a significant difference between both 8H, D07 and D14 compared to pre-trial, suggesting that the product had efficacy in improving skin gloss after 14 days of use and had efficacy in improving skin gloss already at 8H.
3.5 skin L value test results
The skin L value test results are shown in table 3.5.
Table 3.5 skin L values test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.5, the L value of facial skin decreased by 2.3% at 8H, decreased by 0.6% at D07, and increased by 1.5% at D14 compared to pre-trial (D0), with significant differences between 8H and D14 compared to pre-trial, suggesting that the product has efficacy in improving skin brightness after 14 days of use.
3.6 vaccinia Lx value test results
The results of the vaccinia L value test are shown in table 3.6.
TABLE 3.6 vaccinia Lx values test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.6, the value of smallpox L decreased by 1.0% at 8H, increased by 1.0% at D07, and increased by 3.7% at D14, compared to before trial (D0), with a significant difference at D14, suggesting that the product had efficacy in improving the brightness of smallpox after 14 days of use.
3.7 vaccinia a value test results
The results of the vaccinia a value test are shown in table 3.7.
TABLE 3.7 vaccinia a values test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.7, the value of vaccinia a increased by 0.8% at 8H, decreased by 17.1% at D07, and decreased by 14.8% at D14 compared to pre-trial (D0), with a significant difference between D07 and D14 compared to pre-trial, suggesting that the product had improved efficacy for vaccinia flushing after 14 days of use and had already improved efficacy for vaccinia flushing beginning on day 07.
3.8 skin pH test results
Compared with the pH value before trial (D0), the pH value of the facial skin is 6.3 +/-0.5 at D0, 5.5 +/-0.2 at 8H, 6.6 +/-0.3 at D07 and 6.7 +/-0.5 at D14, and is still in the pH range of healthy skin, and the pH value of the facial skin does not damage the normal pH value of human skin after 14 days of use.
3.9 skin pore test results
The skin pore ratio test results are shown in table 3.9.
Table 3.9 skin pore ratio test results
Note: significance representation method: "NS" indicates P > 0.05 with no significant difference; "S" indicates that P is less than or equal to 0.05, and has significant difference.
As can be seen from table 3.9, facial skin pore percentage was reduced by 1.3% at 8H, 0.8% at D07, and 2.0% at D14, compared to pre-trial (D0), with a significant difference at D14 compared to pre-trial, suggesting that the product has efficacy in improving skin pores after 14 days of use.
3.10 test Observation of the results of evaluation by the physician
The acne or acne marks were found on the skin of the left and right sides of 27 subjects, and the evaluation of the acne or acne marks on the left and right sides by the test observer was carried out on these 27 subjects, and the results are shown in Table 3.10. The effective rate of D14 evaluated by doctors in test observation is 74.07%, which has statistical significance and prompts the product to improve pox and pox mark.
TABLE 3.10 evaluation of the test Observation physicians on the face pox of the subjects
Note: 1. and (4) evaluation results: "significant improvement" and "improvement" are considered effective, and "no improvement" and "deterioration" are evaluated as ineffective;
2. significance representation method: "S" means when the efficiency is > 50%, χ2The evaluation results were statistically significant for values > 3.84.
3.11 self-assessment results of the subjects
During the trial period, adverse reactions observed by the testee and observed by a test observation doctor are not appeared temporarily, and the skin is considered to have no adverse reaction according to the classification standard of the adverse reaction of the skin in the safety evaluation of the human trial test specified in 2015 edition of cosmetic safety technical Specification. The results of the subject's self-assessment are shown in table 3.11.
Note: 1. the number of test subjects n was 27, and χ was used2Checking;
2. and (4) evaluation results: 4 is very satisfactory; 3, the comparison is satisfactory; 2 somewhat disagreeable; 1 not agreeing;
3. significance representation method: "S" means when the efficiency is > 50%, χ2The evaluation results were statistically significant for values > 3.84.
Claims (8)
1. A repair cream containing an industrial hemp extract, characterized in that: the raw materials comprise an A-phase raw material, a B-phase raw material, a C-phase raw material and a D-phase raw material, wherein the A-phase raw material comprises the following components in parts by weight: 50-60 parts of water, 1-5 parts of nicotinamide, 0.1-0.6 part of allantoin, 0.2-0.8 part of carboxymethyl deacetylated fructose, 1-10 parts of water-glycerol glucoside-glycerol solution, 1-10 parts of butanediol, 0.1-0.5 part of carbomer and 0.2-1 part of p-hydroxyacetophenone, and the B phase raw material comprises the following components in parts by weight: 1-10 parts of cetearyl alcohol-cetearyl glucoside solution, 1-5 parts of cetearyl olive oleate-sorbitan olive oleate solution, 1-5 parts of hydrogenated polyisobutene, 2-8 parts of isononyl isononanoate, 1-5 parts of polydimethylsiloxane and 0.2-2 parts of tocopherol acetate, and phase C raw materials: 0.1-0.5 part of arginine, and the phase D raw materials: 0.2-1 part of 1, 2-hexanediol, 1-5 parts of panthenol, 1-5 parts of inositol, 0.5-2 parts of centella asiatica extract and 0.5-2 parts of industrial hemp extract.
2. The repair cream containing industrial cannabis extract according to claim 1, characterized by: the CBD content in the industrial hemp extract is 50-60%.
3. The repair cream containing industrial cannabis extract according to claim 1, characterized by: the water-glycerol glucoside-glycerol solution consists of water, glycerol glucoside and glycerol in a mass ratio of 1-3:2-4: 3-5.
4. The repair cream containing industrial cannabis extract according to claim 1, characterized by: the cetearyl alcohol-cetearyl glucoside solution is prepared by mixing cetearyl alcohol and cetearyl glucoside in a mass ratio of 1-3: 1-4.
5. The repair cream containing industrial cannabis extract according to claim 1, characterized by: the cetearyl alcohol olive oleate-sorbitan olive oleate solution is prepared by mixing cetearyl alcohol olive oleate and sorbitan olive oleate according to the mass ratio of 1-2: 1-3.
6. The repair cream containing industrial cannabis extract according to claim 1, characterized by: the preparation method of the repair cream containing the industrial hemp extract comprises the following specific steps:
(1) equipment disinfection: cleaning and disinfecting the vacuum emulsifying pot, the weighing device and all used equipment according to the cleaning and disinfecting process specified by the installation for standby;
(2) weighing raw materials: weighing phase A raw materials, phase B raw materials, phase C raw materials and phase D raw materials in parts;
(3) adding phase A raw materials: putting the phase A raw material into a vacuum emulsifying pot, uniformly stirring, heating to 80-90 ℃, and then homogenizing at a homogenizing speed of 3000r/min for 3-8 minutes until the material body is dissolved uniformly and transparently to form a semitransparent viscous liquid;
(4) adding a phase B raw material: adding the phase B raw material into a stirring tank, heating to 70-90 ℃, uniformly stirring at a stirring speed of 10-30r/min until no particles are completely dissolved, namely yellowish to colorless liquid, quickly and vacuum pumping the dissolved phase B into a vacuum emulsifying pot, homogenizing the vacuum emulsifying pot at a homogenizing speed of 3000r/min at 80-90 ℃ for 3-8min after pumping, and completely and uniformly mixing the material in the vacuum emulsifying pot, wherein the material is a thick liquid which is yellowish white to white; then keeping the temperature at 80-90 ℃ at the stirring speed of 10-30r/min and stirring for 10-30 min;
(5) adding a phase C raw material: cooling to 55-75 deg.C, adding C phase raw material, homogenizing at 55-75 deg.C and 3000r/min for 1-3 min until the material body becomes uniform thick paste;
(6) adding a D-phase raw material: cooling to 40-60 deg.C, adding D phase raw material, homogenizing at 3000r/min for 1-5min until the paste is completely uniform;
(7) discharging: cooling to 38 ℃, taking the materials for inspection, and discharging after the materials are qualified;
(8) product filling: and standing the material body for 5 days, pouring the material body into a filling machine for filling after the micro-inspection is qualified, and completing the preparation of the repair cream containing the industrial hemp extract.
7. The repair cream containing industrial cannabis extract according to claim 6, characterized by: in the step (3), the stirring speed of the phase A raw material is 20-40r/min, and the heating speed is 1 ℃/min; in the step (4), the temperature rising speed of the phase B raw material in the stirring tank is 1 ℃/min.
8. The repair cream containing industrial cannabis extract according to claim 6, characterized by: the cooling speed of the step (5) and the cooling speed of the step (6) are both 1 ℃/min.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2613781A (en) * | 2021-12-07 | 2023-06-21 | Vive Skincare Ltd | Skincare compositions |
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Application publication date: 20210611 |