CN108619018B

CN108619018B - Skin barrier repair cream and preparation method thereof

Info

Publication number: CN108619018B
Application number: CN201810457220.5A
Authority: CN
Inventors: 杨森; 张学军; 张博
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-05-14
Filing date: 2018-05-14
Publication date: 2020-10-02
Anticipated expiration: 2038-05-14
Also published as: CN108619018A

Abstract

The invention discloses a skin barrier repair cream, which is mild and exquisite in texture and comfortable in application through the combined action of optimizing various components and proportioning, has a better skin barrier repair effect through experimental verification, is suitable for various skins, and has certain scar fading and whitening effects. The skin barrier repairing liquid is prepared by adding different components at different temperatures, so that the effective activity of each component is protected, the components are fully mixed, the skin barrier protecting and repairing effects are efficiently and synergistically exerted, and meanwhile, the obtained product is fine in texture, easy to smear and fast to absorb.

Description

Skin barrier repair cream and preparation method thereof

Technical Field

The invention relates to a skin barrier repair cream and a preparation method thereof.

Background

The skin barrier is a tissue organ with the largest area of a human body, covers the surface of the body, forms a first natural defense line of the body facing the external environment, can effectively protect mechanical, physical, chemical and biological external stimuli, and simultaneously regulates the percutaneous absorption of foreign substances and reduces the internal evaporation of water. Healthy skin, undamaged, smooth, soft, full in appearance and feel, but when the skin barrier is compromised, problems arise with the skin.

With the progress of society, the development of economy and the continuous improvement of the living standard of people, the requirements of people on skin change and care are higher and higher. Due to the closed air-conditioned environment, the increasing environmental pollution, frequent washing and bathing, the extensive use of irregular cosmetics causes more and more damages to the skin barrier. Once the skin barrier is damaged, the water loss through the epidermis is increased, the invasion capacity of resisting external microorganisms and physical and chemical factors is weakened, and various skin discomfort and skin problems are caused, such as the reduction of the self-moisturizing capacity of the skin, dryness, fine wrinkles, sensitivity, redness, inflammation and the like. Skin care products with single functions of moisturizing, resisting allergy, repairing scars and the like are difficult to meet the daily requirements of people, so that the research and development of a skin barrier repairing agent with obvious effects is a hot spot concerned by scientific researchers and common people in the field.

Disclosure of Invention

The invention aims to provide a skin care product for repairing skin barriers, which aims at the skin barrier damage caused by various adverse factors, in particular to the skin damage and the sensitive state caused by non-standard cosmetics.

In order to solve the technical problems, the invention discloses a skin barrier repair cream which comprises the following components in percentage by weight: 0.5 to 3 percent of M68 (cetyl glucoside), 1 to 4 percent of XL80(lutensol XL80), 0.2 to 1 percent of A165(A165 emulsifier), 0.5 to 2 percent of DC200 (dimethyl silicone oil), 2 to 5 percent of squalane, 1 to 3 percent of IPM (grease for cosmetics), 1 to 3 percent of vaseline, 3 to 6 percent of C16-18(C16-18 mixed alcohol), 2 to 6 percent of glycerol, 0.5 to 3 percent of butanediol, 0.05 to 0.2 percent of allantoin, 0.02 to 0.08 percent of EDTA-2 Na0.08 percent, 60 to 75 percent of deionized water, 0.05 to 0.4 percent of xanthan gum, 0.02 to 1 percent of HHR250 (hydroxyethyl cellulose HHR-250), 0.5 to 2 percent of 305(Sepigel 305), 0.1 to 0.5 percent of panthenol, 0.5 to 2 percent of trehalose, 10.5 to 2 percent of bioglycan extract of plant root, 0.02 to 0.2 percent of dipotassium glycyrrhizinate, 0.05-0.4 percent of ceramide, 2-4 percent of butanediol, 0.2-1 percent of H60 (sericite powder) and 0.2-1 percent of menthone. 0.05-0.3% of T-BFGF (basic fibroblast growth factor).

Preferably comprises the following components in percentage by weight: 1% of M68 (cetyl glucoside), 2% of XL80(lutensol XL80), 0.5% of A165(A165 emulsifier), 1% of DC200 (dimethyl silicone oil), 3% of squalane, 2% of IPM (grease for cosmetics), 2% of vaseline, 5% of C16-18(C16-18 mixed alcohol), 4% of glycerol, 2% of butanediol, 0.1% of allantoin, 0.05% of EDTA-2 Na0.05%, 69.1% of deionized water and 0.2% of xanthan gum; HHR250 (hydroxyethyl cellulose HHR-250) 0.05%, 305(Sepigel 305) 1.05%, panthenol 0.3%, trehalose 1%, bioglycan-11%, RPE (peony root extract as plant preservative) 0.3%, dipotassium glycyrrhizinate 0.05%, ceramide 0.2%, butanediol 3%, H60 (sericite powder) 0.5%, menthone 0.5%, T-BFGF (basic fibroblast growth factor) 0.1%.

The skin barrier repair cream disclosed by the invention can be prepared by the following steps of 1) mixing and dispersing glycerol, butanediol, allantoin, EDTA-2Na and deionized water to obtain a B phase; 2) mixing xanthan gum and HHR250, and dispersing to obtain B1 phase; 3)305, panthenol, trehalose, bioglycan-1, PRE and dipotassium glycyrrhizinate, and dispersing to obtain phase C; 4) mixing butanediol, H60 and menthone, and dispersing to obtain phase E; 5) adding M68, XL80, A165, DC200, squalane, IPM, vaseline and C16-18 into an oil pan, mixing to obtain phase A, stirring and heating; 6) adding phase B and phase B1 into an emulsifying pot, stirring, heating, and homogenizing; 7) pumping phase A into emulsifying pot under stirring, vacuum homogenizing, maintaining temperature, cooling, adding phase C, vacuum homogenizing, further cooling, adding phase D (ceramide), phase E and phase F (T-BFGF), and stirring.

Preferably, mixing, stirring and heating the phase A in the step 5) to 75-85 ℃; step 6), stirring the phase B and the component B1, and heating to 85-95 ℃; and 7) pumping the phase A into an emulsifying pot, vacuumizing and homogenizing, keeping the temperature for 20-40 minutes, cooling to 45-55 ℃, adding the phase C, and continuously cooling to 40-50 ℃ to add the phase D, the phase E and the phase F. More preferably, the phase A in the step 5) is mixed, stirred and heated to 80 ℃, the phase B and the phase B1 in the step 3) are stirred and heated to 90 ℃, the phase A in the step 7) is pumped into an emulsifying pot, the mixture is vacuumized and homogenized, the temperature is kept for 30 minutes, then the mixture is cooled to 50 ℃, the phase C is added, and the mixture is continuously cooled to 45 ℃ and added with the phase D, the phase E and the phase F.

The skin barrier repair cream disclosed in the present invention contains ceramide, which is a repair agent for aging resistance and sunlight damage, and has excellent permeability to impart new effects thereto. Natural moisture retention and integrity protection of the dermis, skin balance maintenance and youth color reproduction. Ceramides have a strong ability to associate water molecules, and maintain the moisture of the skin through a network structure formed in the stratum corneum. Ceramides form a network in the stratum corneum to associate water molecules, and retain water in the skin. Therefore, ceramide has a strong moisturizing effect on the skin. In the process of skin aging, lipid synthesis is reduced, the content of ceramide in the horny layer is reduced, and the skin is dry, desquamation, rough and lustrous; ceramide can increase ceramide content in horny layer of skin, and can improve symptoms of xerosis cutis, desquamation, pachylosis, etc.; the basic fibroblast growth factor contained in the skin care product can improve the microenvironment of cell growth, promote the synthesis of elastic fibers and collagen, enable the skin to be rich in elasticity and enable the skin to be in a smooth and tender state. Can promote the growth and development of fibroblasts, and continuously replace aged cells with new cells, thereby having the effects of preventing and removing wrinkles. The aged cells are renewed, so that the content of melanin and colored cells in skin cells is reduced, the skin pigmentation is reduced, damaged cells can be quickly repaired, and the damage of ultraviolet radiation to the skin is reduced. Stimulating the formation of granulation tissue of skin, promoting the epithelialization of granulation tissue, and regulating the degradation and renewal of collagen, thereby shortening wound healing time, reducing scar, and whitening skin. The combined use of the ceramide and the basic fibroblast factors acts on the repair of the skin barrier, the various components are selected preferably and the proportion is optimized, the combined action is realized, the texture of the obtained skin barrier repair cream is mild and exquisite, the application is comfortable, and the skin barrier repair cream has a good skin barrier repair effect through experimental verification, is suitable for various skins with damaged barriers, has a certain scar fading effect and a certain whitening effect, and has an efficient protection effect on normal skin. The preparation method is prepared by adding different components at different temperatures, so that the activity of each component is protected, the effect can be fully exerted, the components are fully mixed, and the obtained product is fine in texture and easy to apply. The formula uses plant extracts to replace the preservative and flavor effects of conventional chemicals in cosmetics, and the effect of sensitive skin and skin sensitization caused by chemical use is greatly reduced after the formula is optimized.

In a word, the formula is novel, efficient and good in safety, the damage of the skin barrier is greatly reduced when the medicine is used, and the effects of repairing the skin barrier and relieving the skin are achieved.

Detailed Description

The above-mentioned aspects of the present invention will be further described in detail with reference to the following specific examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. Various substitutions and alterations according to the general knowledge and conventional practice in the art are intended to be included within the scope of the present invention without departing from the technical spirit of the present invention as described above.

Example 1

Prescription:

the preparation method comprises the following steps:

1) phase B (glycerol, butanediol, allantoin, EDTA-2Na, deionized water), phase B1 (xanthan gum; HHR250), C phase (305, panthenol, trehalose, biological sugar gum-1, PRE, dipotassium glycyrrhizinate) and E phase (butanediol, H60, fragrant fresh ketone) by mixing and dispersing respectively;

2) adding phase A (M68, XL80, A165, DC200, squalane, IPM, vaseline 2% and C16-18) into an oil pan, mixing, stirring and heating to 75 ℃;

3) adding the phase B and the phase B1 into an emulsifying pot, stirring, heating, and homogenizing for 1 minute;

4) pumping the phase A into an emulsifying pot under stirring, vacuumizing and homogenizing for 10 minutes, keeping the temperature for 20 minutes, cooling to 55 ℃, adding the phase C, vacuumizing and homogenizing for 3 minutes, continuously cooling to 45 ℃, adding the phase D (ceramide), the phase E and the component F (T-BFGF), and stirring uniformly to obtain the finished product.

Example 2

Prescription:

the preparation method comprises the following steps:

2) adding phase A (M68, XL80, A165, DC200, squalane, IPM, vaseline 2% and C16-18) into an oil pan, mixing, stirring and heating to 85 ℃;

3) adding the phase B and the phase B1 into an emulsifying pot, stirring, heating to 90 ℃, and homogenizing for 1 minute;

4) pumping the phase A into an emulsifying pot under stirring, vacuumizing and homogenizing for 30 minutes, keeping the temperature for 30 minutes, cooling to 45 ℃, adding the phase C, vacuumizing and homogenizing for 3 minutes, continuously cooling to 40 ℃, adding the phase D, the phase E and the phase F, and stirring uniformly to obtain the emulsion.

Example 3

Prescription:

the preparation method comprises the following steps:

4) pumping the phase A into an emulsifying pot under stirring, vacuumizing and homogenizing for 10 minutes, keeping the temperature for 30 minutes, cooling to 55 ℃, adding the phase C, vacuumizing and homogenizing for 3 minutes, continuously cooling to 45 ℃, adding the phase D, the phase E and the phase F, and stirring uniformly to obtain the emulsion.

Example 4

Prescription:

the preparation method comprises the following steps:

3) adding the phase B and the phase B1 into an emulsifying pot, stirring, heating to 95 ℃, and homogenizing for 1 minute; 4) pumping the phase A into an emulsifying pot under stirring, vacuumizing and homogenizing for 20 minutes, keeping the temperature for 20 minutes, cooling to 55 ℃, adding the phase C, vacuumizing and homogenizing for 3 minutes, continuously cooling to 45 ℃, adding the phase D, the phase E and the phase F, and stirring uniformly to obtain the emulsion.

Example 5

Prescription:

the preparation method comprises the following steps:

2) adding phase A (M68, XL80, A165, DC200, squalane, IPM, vaseline 2% and C16-18) into an oil pan, mixing, stirring and heating to 80 ℃;

3) adding the phase B and the phase B1 into an emulsifying pot, stirring, heating to 90 ℃, and homogenizing for 1 minute; 4) pumping the phase A into an emulsifying pot under stirring, vacuumizing and homogenizing for 10 minutes, keeping the temperature for 30 minutes, cooling to 50 ℃, adding the phase C, vacuumizing and homogenizing for 3 minutes, continuously cooling to 45 ℃, adding the phase D, the phase E and the phase F, and stirring uniformly to obtain the emulsion.

The test results of the skin barrier repair cream prepared by the above embodiment of the present invention are as follows:

1) the skin barrier repair cream obtained by the embodiment has uniform color and luster, fine texture and easy smearing, and has no layering phenomenon after being centrifuged at the rotating speed of 4000r/min for 30min and placed at the temperature of 40 ℃ and 75% RH for more than 6 months.

2) Allergy testing of skin barrier repair creams prepared in the above examples: selecting 300 cosmetic sensitive skin disease patients, randomly dividing into 6 groups, respectively marking as a blank control group and an example group, and 50 persons/group, respectively taking 0.05mg deionized water or samples prepared in examples 1-5, smearing on a filter paper sheet of a spot tester, placing in the spot tester, and carrying out a closed spot-sticking test: the spot tester with the tested object is pasted on the upper back of the tested object by using a non-irritating adhesive tape, the spot testing adhesive tape is removed after 48 hours, in order to avoid the reaction caused by pressing the skin by the spot tester, the test result is observed after the spot tester is removed and the patient sits statically for at least 30 minutes (until the impression of the spot tester disappears), and the first result judgment is carried out; carrying out secondary observation on test results 24h after the spot tester is removed; and (5) carrying out third observation test results 48h after the spot tester is removed.

Referring to the implementation guidelines of cosmetic skin disease diagnosis standards and treatment principles, the reaction degree judgment standard of the tested part is as follows:

a. no skin reaction (-);

b. the skin is pale erythema and has no infiltration (+/-);

c. the skin is erythematous, infiltrative, papular (+);

d. the skin presents as erythema, edema, papules, small blisters (++);

e. large blisters (+++), appear on erythema and edema of the skin. The number of allergic people is counted, and the result shows that the number of non-allergic people in the example group is far more than that in the blank control group, and the number of allergic people is less than that in the control group, so that the skin barrier repair cream disclosed by the invention is excellent in anti-allergic effect, can relieve the allergic symptoms of skin allergic patients, is suitable for most of skin allergic patients, and is low in the degree of allergy caused. Specific results are shown in table 1 below:

TABLE 1

3) Scar lightening efficacy test of the skin barrier repair cream prepared in the examples: 300 volunteers with acne scars are randomly divided into 6 groups, which are respectively marked as a blank control group and an example group, and 50 persons/group, wherein the blank groups are removed after each 4 hours of face cleaning, the prepared samples of examples 1-5 are respectively applied to the acne scars for 4 weeks, other cosmetics are not used during the trial period, the fading condition of the scars of the control group and the experimental group is observed, and the effect evaluation is as follows:

and (3) curing: the acne scars disappear;

the effect is shown: the position of the acne scar is smooth and the skin color is natural;

the method has the following advantages: the acne scar can be visually identified and reduced;

and (4) invalidation: no obvious difference from the prior use. The results show that the skin barrier repair cream prepared in the example has a certain scar fading effect, and the specific results are shown in the following table 2:

4) example-prepared skin barrier repair cream injury repair effect test 300 volunteers (age 25-40 years old) were randomly divided into 6 groups according to the parallel control principle, and respectively marked as blank control group and example group, 50 persons/group, with 3 × 3cm at the inner side of arm²The skin moisture tester Corneometer CM825 and the skin elasticity tester Cutomer dual MPA580, which are produced by Germany COARAGE + KHAZAKA (CK), are used for respectively testing the moisture content and the skin elasticity index of the skin, after the test, 50% ethanol solution is used for wiping for 5min, the samples of examples 1 to 5 are respectively smeared after the personnel in the examples stand for 20min, the test is carried out immediately, and then the test is carried out for 1 time after 1h, 2h and 6h respectively, and the test effect is observed. The blank control group personnel wipe with 50% ethanol solution and do not carry out any treatment, and test 1 time after 1h, 2h and 6h respectively, and observe the natural repair effect. Wherein the ethanol can partially dissolve the lipid components of stratum corneum, and destroy the original structure, resulting in impaired barrier function. The results show that the skin barrier repair cream prepared in the examples has a good skin barrier damage repair effect, and the specific results are shown in the following table 3:

TABLE 3

5) Long-term repair function test of skin barrier repair cream prepared in example: 300 volunteers (age 25-40 years) were randomized into 6 groups on the basis of parallel control, and labeled as blank control and example group, 50 persons/group, respectively. Each group was prepared using examples 1-5 with the blank component removed after morning evening each day for 4 weeks without the use of other cosmetics during the trial period. Before application (0 week), after application for 1 week, after application for 2 weeks, after application for 3 weeks, after application for 4 weeks, skin moisture content and skin elasticity index were measured using a skin moisture meter CM825 and a skin elasticity meter dual mpa580, respectively, manufactured by couage + khazaka (ck) of germany, and the average of the percentage of increase in skin moisture and the percentage of increase in elasticity index per week was counted for the volunteers. The result shows that the skin barrier repair cream prepared in the example has a good repair effect and the skin improvement degree is obvious. The specific results are shown in table 4 below:

TABLE 4

Claims

1. A skin barrier repair cream characterized by: the paint consists of the following components in percentage by weight: 0.5-3% of cetyl glucoside, 801-4% of lutensol XL, 0.2-1% of A165 emulsifier, 0.5-2% of dimethyl silicone oil, 2-5% of squalane, 1-3% of oil for cosmetics, 1-3% of vaseline, 3-6% of C16-18 mixed alcohol, 2-6% of glycerol, 0.5-3% of butanediol, 0.05-0.2% of allantoin, 0.02-0.08% of EDTA-2Na0.02, 60-75% of deionized water, 0.05-0.4% of xanthan gum, 0.05-0.4% of hydroxyethyl cellulose HHR-2500.02-1%, 0.5-2% of Sepigel 3050.5%, 0.1-0.5% of panthenol, 0.5-2% of trehalose, 10.5-2% of bioglycan gum, 0.1-0.5% of RPE (a plant preservative, a peony root extract), 0.02-0.2% of dipotassium glycyrrhizinate, and 0.05-0.4% of; 2 to 4 percent of butanediol, 0.2 to 1 percent of sericite powder, 0.2 to 1 percent of jasminolone and 0.05 to 0.3 percent of basic fibroblast growth factor;

the preparation method of the skin barrier repair cream comprises the following steps:

1) mixing and dispersing glycerol, butanediol, allantoin, EDTA-2Na and deionized water to obtain phase B;

2) mixing xanthan gum and hydroxyethyl cellulose HHR-250, and dispersing to obtain B1 phase;

3) mixing Sepigel305, panthenol, trehalose, biological carbohydrate gum-1, a composite anti-allergy agent and dipotassium glycyrrhizinate, and dispersing to obtain a C phase;

4) mixing butanediol, sericite powder and menthocamphonate, and dispersing to obtain phase E;

5) cetyl glucoside, lutensol XL80, A165 emulsifier, dimethyl silicone oil, squalane, cosmetic oil, and cosmetic oil,

Adding vaseline and C16-18 mixed alcohol into oil pan, mixing to obtain phase A, stirring, and heating;

6) adding phase B and phase B1 into an emulsifying pot, stirring, heating, and homogenizing;

7) pumping the phase A into an emulsifying pot under stirring, vacuumizing, homogenizing, keeping the temperature, cooling, adding the phase C, vacuumizing, homogenizing, continuously cooling, adding ceramide, the phase E and the basic fibroblast growth factor, dispersing, and stirring uniformly.

2. The skin barrier repair cream of claim 1, wherein: the paint consists of the following components in percentage by weight:

1% of cetyl glucoside, 0.5% of lutensol XL 802%, 0.5% of A165 emulsifier, 1% of dimethyl silicone oil, 3% of squalane, 2% of cosmetic grease, 2% of vaseline, 5% of C16-18 mixed alcohol, 4% of glycerol, 2% of butanediol, 0.1% of allantoin, 0.05% of EDTA-2 Na0.05%, 69.1% of deionized water, 0.2% of xanthan gum, 0.32% of hydroxyethyl cellulose HHR-2500.05%, Sepigel 3051.05%, 0.3% of panthenol, 1% of trehalose, 11% of biosaccharide gum, 0.3% of RPE (plant preservative, namely, a peony root extract), 0.05% of dipotassium glycyrrhizinate, 0.2% of ceramide, 3% of butanediol, 0.5% of sericite powder, 0.5% of carnation ketone and 0.1% of alkaline fibroblast growth factor.

3. The skin barrier repair cream of claim 1, wherein: mixing, stirring and heating the phase A in the step 5) to 75-85 ℃.

4. The skin barrier repair cream of claim 1, wherein: and 6) stirring the phase B and the component B1, and heating to 85-95 ℃.

5. The skin barrier repair cream of claim 1, wherein: and 7) pumping the phase A into an emulsifying pot, vacuumizing and homogenizing, keeping the temperature for 20-40 minutes, cooling to 45-55 ℃, adding the phase C, continuously cooling to 40-50 ℃, and adding the ceramide, the phase E and the basic fibroblast growth factor.

6. The skin barrier repair cream of claim 1, wherein: mixing, stirring and heating the phase A to 80 ℃ in the step 5); step 3), stirring the phase B and the phase B1, and heating to 90 ℃; and 7) pumping the phase A into an emulsifying pot, vacuumizing and homogenizing, keeping the temperature for 30 minutes, cooling to 50 ℃, adding the phase C, continuously cooling to 45 ℃, and adding the ceramide, the phase E and the basic fibroblast growth factor.