CN102836093B - Facial cream containing type I collagen - Google Patents
Facial cream containing type I collagen Download PDFInfo
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- CN102836093B CN102836093B CN 201210362813 CN201210362813A CN102836093B CN 102836093 B CN102836093 B CN 102836093B CN 201210362813 CN201210362813 CN 201210362813 CN 201210362813 A CN201210362813 A CN 201210362813A CN 102836093 B CN102836093 B CN 102836093B
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Abstract
The invention discloses a facial cream containing type I collagen and a preparation method thereof. The facial cream consists of the following components in percentage by mass: 3-8 percent of glycerol, 0.01-0.05 percent of EDTA (Ethylene Diamine Tetraacetic Acid) Na2, 1-3 percent of fucose, 0.1-0.3 percent of methylparaben, 0.05-0.2 percent of propylben, 0.1-0.5 percent of allantoin, 0.5-2 percent of VC (Vitamin C) ethyl ether, 0.5-2 percent of vitamin B3, 0.5-1 percent of dipotassium glycyrrhizinate, 1-2 percent of M68, 1-10 percent of A165, 1-2 percent of 16-18 alcohol, 1-2 percent of DC200, 2-10 percent of GTCC (Caprylic/Capric Triglyceride), 1.5-10 percent of shea butter, 3-6 percent of cupuacu butter, 1-5 percent of 2EHP (Isooctyl Palmitate), 0.1-1 percent of vitamin A acetic ester, 0.4-1 percent of vitamin E acetic ester, 0.01-0.1 percent of piperine, 0.5-2 percent of type I collagen, 0.01-0.05 percent of essence, 0.1-0.5 percent of S-304, 1-5 percent of LS8740 and 50-75 percent of deionized water. The facial cream is prepared according to the method provided by the invention; and the facial cream contains type I collagen, has high absorptivity, can be used for deeply moistening and humidifying skin and replenishing water for skin, and has multiple skin-protecting and beautifying effects of nourishing skin, increasing skin elasticity, whitening, lightening speckles, reducing wrinkles and the like. As proved by test, the facial cream is very safe and has a good effect.
Description
Technical field:
The present invention relates to a kind of human body skin and repair articles for use, particularly a kind of facial cream that contains type i collagen albumen and manufacture method thereof.
Background technology:
Collagen protein is a huge family, of a great variety, and high level of architectural complexity from molecular structure, supramolecular structure, then, to tissue distribution and function etc., has significant multiformity.They are present in the various tissues of human body, as, skin, bone, cornea, tendon, cartilage, vitreous body, Uterus wall, blood vessel wall, basement membrane, Placenta Hominis, endotheliocyte etc.Type i collagen albumen more is present in the skin, skeleton, blood vessel of human body etc. and plants in tissue.Several factors all can cause the loss of various nutrition compositions, and the loss of collagen protein can cause supporting collagen peptide bond and the elasticated net fracture of skin, its spiral net-shaped structure is destroyed immediately, skin histology is oxidized, atrophy, subside, and drying, wrinkle appear in skin thus, the aging phenomenon such as nonelastic relaxes.
Summary of the invention:
Based on above-mentioned cognition, the inventor has also designed the various type i collagen protein prescriptions that are added with, and to realizing, helps the maintenance skin, and the reconstructed collagen albumin layer, improve elasticity, the moisture of skin, and then play skin whitening, the anti-ageing effect of moisturizing.Through a large amount of test, it is simple that the inventor has developed a kind of preparation technology finally, and raw material is few but can reach the skin care item of above-mentioned many effects.
The purpose of this invention is to provide a kind of elasticity, moisture that improves skin, there is skin protection facial cream of the anti-ageing effect of whitening skin and preserving moisture and preparation method thereof.
Purpose of the present invention is achieved through the following technical solutions:
The mass percent of facial cream consists of: glycerol 3-8%, EDTA Na
20.01-0.05%, trehalose 1-3%, methyl hydroxybenzoate 0.1-0.3%, propylparaben 0.05-0.2%, allantoin 0.1-0.5%, VC ethylether 0.5-2%, vitamin B3 0.5%-2%, glycyrrhizic acid dipotassium salt 0.5-1%, M68 1-2%, A 165 1-10%, 16-18 alcohol 1-2%, DC200 1-2%, GTCC 2-10%, shea butter 1.5-10%, simple and unsophisticated A Su fruit oil 3-6%, 2EHP 1-5%, vitamin A acetate 0.1-1%, Vitamin E acetate 0.4-1%, piperine 0.01-0.1%, type i collagen albumen 0.5-2%, essence 0.01-0.05%, S-305 0.1-0.5%, LS8740 1-5%, deionized water 50-75%.
Facial cream of the present invention is preferably as follows preparation method, comprises step:
1) get glycerol 3-8% by quality, EDTA Na
20.01-0.05%, trehalose 1-3%, methyl hydroxybenzoate 0.1-0.3%, propylparaben 0.05-0.2%, allantoin 0.1-0.5%, VC ethylether 0.5-2%, vitamin B3 0.5%-2%, glycyrrhizic acid dipotassium salt 0.5-1%, M68 1-2%, A 165 1-10%, 16-18 alcohol 1-2%, DC200 1-2%, GTCC 2-10%, shea butter 1.5-10%, simple and unsophisticated A Su fruit oil 3-6%, 2EHP 1-5%, vitamin A acetate 0.1-1%, Vitamin E acetate 0.4-1%, piperine 0.01-0.1%, type i collagen albumen 0.5-2%, essence 0.01-0.05%, S-305 0.1-0.5%, LS8740 1-5%, deionized water 50-75%.
2) preparation A phase: by deionized water, glycerol, EDTA Na
2, trehalose, allantoin, VC ethylether, vitamin B3, glycyrrhizic acid dipotassium salt and institute's taken amount 1/2 methyl hydroxybenzoate put into successively container, be heated to 80 ℃ under stirring.
3) preparation B phase: in the time of preparation A phase, by M68, A 165,16-18 alcohol, DC200, GTCC, shea butter, simple and unsophisticated A Su fruit oil, 2EHP, vitamin A acetate, Vitamin E acetate, piperine, propylparaben and the methyl hydroxybenzoate that remains 1/2 amount are put into another container successively, are heated to 80 ℃ under stirring.
4) A is added to B mutually in, with 5000-12000rpm, stir to homogenizing; Naturally cool to 60 ℃.
5) S-305 is joined in step 4) gained uniform homogeneous blend, stir to homogenizing with 5000-12000rpm, naturally cool to 40 ℃.
6) type i collagen albumen is added in step 5) gained uniform homogeneous blend, stirs with 800-1500rpm.
7) LS8740, essence are joined in step 6) gained mixture, with the 800-1500rpm stirring and evenly mixing.
8) fill, labeling, be up to the standards, the packing.
Writing a Chinese character in simplified form of adopting in the present invention is expressed as follows implication:
EDTA Na
2: disodiumedetate;
VC ethylether: VCE;
M68: cetyl glucoside
A 165: glyceryl monostearate
DC200: dimethicone DC-200;
GTCC: caprylic/capric triglyceride;
2EHP: iso-octyl palmitate;
S-305: match Bick SEPIGEL 305 emulsifying agents;
LS8740: the LS of Kening Co.,Ltd active additive serial model No.: LS8740
16-18 alcohol: cetostearyl alcohol, C16:C18=3:7
In the present invention, the Main Function of various compositions is:
1. hexadeca-octadecyl alcohol glucoside, self emulsifying glyceryl monostearate, S-305 are emulsifying agent.
2. sad capric acid triglyceride and iso-octyl palmitate are isostearyl glyceryl pentaerythrityl ether.
3. vitamin A acetate is the necessary factor of regulating Epithelial cell growth and health, makes coarse aging skin surface attenuation, promotes cell metabolism normalization, the wrinkle removal successful.
4. a kind of novel microcirculation activator of vitamin E Nicotinate, can directly act on blood vessel wall, the diastole peripheral vessels, promote the blood circulation of skin, improve skin elasticity, delaying skin is aging has certain effect, and can reduce the content because of the aged pigment of age increase, there is whitening effect.
5. α-bisabolol has the scytitis of reduction effect, and can reduce product simultaneously stimulates, and improves the irritation ability of skin.
6. BSJ15 has the function of hygroscopicity and maintenance moisture content.
7. allantoin has lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, can make skin keep moisture content, moist and soft.
8.I collagen type enters skin corium and helps the maintenance skin, the reconstructed collagen albumin layer improves elasticity, the moisture of skin, and then skin whitening, plays the anti-ageing effect of moisturizing.
9. the nicotiamide external can reduce the generation of fatty acid and triglyceride in sebum, thereby receives the fine, soft fur hole and reduce acne the order of severity while occurring.
Advantage and disadvantage of the present invention is:
1. adding type i collagen albumen in the present invention is the medical grade collagen protein extracted from the Mus tail of specific pathogen free, and pure natural extracts the high-tech biological product prepared through biotechnology, safe.
2. this product absorbability is good, can enter dermal tissue reparation fracture, aging elastic fibrous web, thereby increase tight skin density, reduces deep wrinkle, the microgroove that calms down, and makes skin-tightening and high resilience.
3. this product can be accelerated cell turnover speed.Improve skin elasticity from deep layer, moisten, moisturizing, anti-ageing effect be obvious.
4. this product is in conjunction with LS8740 active additive, multivitamin, shea butter and simple and unsophisticated A Su fruit oil, further improves that it moistens, moisturizing, reparation, anti-ageing effect, reaches many efficacy effects.
The specific embodiment
In order to understand better the present invention, below in conjunction with embodiment, the invention will be further described, but do not limit the present invention.
Embodiment 1
Get by mass percentage glycerol 5%, EDTA Na
20.03%, trehalose 1%, methyl hydroxybenzoate 0.2%, propylparaben 0.05%, allantoin 0.3%, VC ethylether 2%, vitamin B3 1%, glycyrrhizic acid dipotassium salt 0.5%, M682%, A 1652%, 16-18 alcohol 2%, DC200 1.5%, GTCC 4%, shea butter 2%, simple and unsophisticated A Su fruit oil 3%, 2EHP 5%, vitamin A acetate 0.5%, Vitamin E acetate 0.5%, piperine 0.05%, type i collagen albumen 1%, essence 0.02%, S-305 0.3%, and LS8740 2%, deionized water 64.05%.
By deionized water, glycerol, EDTA Na
2, trehalose, allantoin, VC ethylether, vitamin B3, glycyrrhizic acid dipotassium salt and 0.1% methyl hydroxybenzoate put into container A successively, is heated to 80 ℃ under stirring; Simultaneously another extracting container B, successively by M68, A 165,16-18 alcohol, DC200, GTCC, shea butter, simple and unsophisticated A Su fruit oil, 2EHP, vitamin A acetate, Vitamin E acetate, piperine, propylparaben and 0.1% methyl hydroxybenzoate are put into, and are heated to 80 ℃ under stirring; Then the mixture in the A container is joined in the B container, and stir to homogenizing with 5000-12000rpm; Naturally cool to 60 ℃; Add wherein again S-305, stir to homogenizing with 5000-12000rpm, naturally cool to 40 ℃; Add wherein again type i collagen albumen, stir with 800-1500rpm.Finally add wherein LS8740, essence, with the 800-1500rpm stirring and evenly mixing; Fill, labeling, be up to the standards, must contain the facial cream of NTx albumen.
Embodiment 2
Get by mass percentage glycerol 6%, EDTA Na
20.03%, trehalose 2%, methyl hydroxybenzoate 0.2%, propylparaben 0.05%, allantoin 0.4%, VC ethylether 2%, vitamin B3 0.5%, glycyrrhizic acid dipotassium salt 0.5%, M68 2%, A 165 3%, 16-18 alcohol 2%, DC2002%, GTCC 6%, shea butter 3%, simple and unsophisticated A Su fruit oil 3%, 2EHP 4%, vitamin A acetate 1%, Vitamin E acetate 1%, piperine 0.01%, type i collagen albumen 0.5%, essence 0.01%, S-305 0.3%, and LS8740 2%, deionized water 58.5%;
Press the method operation of embodiment, must contain the facial cream of NTx albumen.
Embodiment 3
Get by mass percentage glycerol 7%, EDTA Na
20.03%, trehalose 3%, methyl hydroxybenzoate 0.2%, propylparaben 0.05%, allantoin 0.2%, VC ethylether 1%, vitamin B3 1.5%, glycyrrhizic acid dipotassium salt 0.5%, M68 2%, A 1654%, 16-18 alcohol 2%, DC200 2%, GTCC 8%, shea butter 4%, simple and unsophisticated A Su fruit oil 3%, 2EHP 3%, vitamin A acetate 0.5%, Vitamin E acetate 0.5%, piperine 0.05%, type i collagen albumen 2%, essence 0.01%, S-305 0.3%, LS87403%, deionized water 52.16%.
Press the method operation of embodiment, must contain the facial cream of NTx albumen.
Test example
Experimental subject: 42 routine triers, male 13 examples wherein, women's 29 examples.Year mean age (30.3 ± 8.4).
Test method:
1. grouping: contrast group (A group) on probation, the present invention tries out group (B group), and matched group is the commodity facial cream that is marked with identical effect
2. the trier sooner or later evenly is applied in face by facial cream after clean, and the right face of all triers is smeared similar commodity facial cream (A group), and left face is smeared facial cream of the present invention (B group), continues 8 weeks, and all triers face is not used other skincare products in the trial employment period.
3. the position that cheekbone is the highest is as the test position, center probe is aimed at the test position, adopts skinanalysis apparatus (Cutometer MPA 580) before on probation and after on probation and detects experimenter left and right test position section elasticity number, melanin value, moisture content value after 8 weeks.Adopt German CK image analyzer photographic analysis.The each detection tested by same people, same instrument.
4. calculate the score value that improves that every trier uses rear test position section elasticity number, moisture content value, computational methods: (test value after on probation-front test value on probation)/test value * 100% before trying out; Melanin value is improved a minute value calculating method: (test value before trying out-test value after trying out)/front test value on probation * 100%.Calculate each class value and improve score value at≤20%, 20-40%, the number in >=40% three interval.
5. result adopts SPSS 16.0 statistical analysis softwares to carry out X 2 test.P<0.05 difference has statistical significance, and P >=0.05 difference does not have statistical significance.
6. result
The score value that improves that after 8 weeks on probation, trier face part of detecting is elasticity, melanin, moisture carries out the statistical analysis discovery in different interval numbers, this product is significantly improved in elasticity and moisture, and the more similar commodity of the situation of improving aspect are good, difference has statistical significance (P<0.05).This product is significantly improved black, and the more similar commodity of data show improvement are good, but difference does not have statistical significance (P >=0.05).Result of the test is in Table 1.In the trial employment period, irritated grade for ill symptoms appears in none example of all triers.
The score value that improves of table 1 elasticity, melanin, moisture after 8 weeks on probation compares in different interval numbers
Claims (2)
1. a facial cream that contains NTx albumen, is characterized in that its mass percent consists of: glycerol 3-8%, EDTA Na
20.01-0.05%, trehalose 1-3%, methyl hydroxybenzoate 0.1-0.3%, propylparaben 0.05-0.2%, allantoin 0.1-0.5%, VC ethylether 0.5-2%, vitamin B3 0.5%-2%, glycyrrhizic acid dipotassium salt 0.5-1%, cetyl glucoside 1-2%, glyceryl monostearate 1-10%, 16-18 alcohol 1-2%, dimethicone DC-200 1-2%, caprylic/capric triglyceride 2-10%, shea butter 1.5-10%, simple and unsophisticated A Su fruit oil 3-6%, iso-octyl palmitate 1-5%, vitamin A acetate 0.1-1%, Vitamin E acetate 0.4-1%, piperine 0.01-0.1%, type i collagen albumen 0.5-2%, essence 0.01-0.05%, match Bick SEPIGEL305 emulsifying agent 0.1-0.5%, LS8740 1-5%, deionized water 50-75%,
Described LS8740 is the product that in the LS of Kening Co.,Ltd active additive series, model is LS8740.
2. the preparation method of a kind of facial cream that contains NTx albumen according to claim 1 is characterized in that comprising step:
1) get glycerol 3-8% by quality, EDTA Na
20.01-0.05%, trehalose 1-3%, methyl hydroxybenzoate 0.1-0.3%, propylparaben 0.05-0.2%, allantoin 0.1-0.5%, VC ethylether 0.5-2%, vitamin B3 0.5%-2%, glycyrrhizic acid dipotassium salt 0.5-1%, cetyl glucoside 1-2%, glyceryl monostearate 1-10%, 16-18 alcohol 1-2%, dimethicone DC-200 1-2%, caprylic/capric triglyceride 2-10%, shea butter 1.5-10%, simple and unsophisticated A Su fruit oil 3-6%, iso-octyl palmitate 1-5%, vitamin A acetate 0.1-1%, Vitamin E acetate 0.4-1%, piperine 0.01-0.1%, type i collagen albumen 0.5-2%, essence 0.01-0.05%, match Bick SEPIGEL305 emulsifying agent 0.1-0.5%, LS8740 1-5%, deionized water 50-75%,
2) preparation A phase: by deionized water, glycerol, EDTA Na
2, trehalose, allantoin, VC ethylether, vitamin B3, glycyrrhizic acid dipotassium salt and institute's taken amount 1/2 methyl hydroxybenzoate put into successively container, be heated to 80 ℃ under stirring;
3) preparation B phase: in the time of preparation A phase, by cetyl glucoside, glyceryl monostearate, 16-18 alcohol, dimethicone DC-200, caprylic/capric triglyceride, shea butter, simple and unsophisticated A Su fruit oil, iso-octyl palmitate, vitamin A acetate, Vitamin E acetate, piperine, propylparaben and the methyl hydroxybenzoate that remains 1/2 amount are put into another container successively, are heated to 80 ℃ under stirring;
4) A is added to B mutually in, with 5000-12000rpm, stir to homogenizing; Naturally cool to 60 ℃;
5) will match Bick SEPIGEL305 emulsifying agent and join in step 4) gained uniform homogeneous blend, stir to homogenizing with 5000-12000rpm, naturally cool to 40 ℃;
6) type i collagen albumen is added in step 5) gained uniform homogeneous blend, stirs with 800-1500rpm;
7) LS8740, essence are joined in step 6) gained mixture, with the 800-1500rpm stirring and evenly mixing;
8) fill, labeling, be up to the standards, the packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210362813 CN102836093B (en) | 2012-09-26 | 2012-09-26 | Facial cream containing type I collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210362813 CN102836093B (en) | 2012-09-26 | 2012-09-26 | Facial cream containing type I collagen |
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| CN102836093A CN102836093A (en) | 2012-12-26 |
| CN102836093B true CN102836093B (en) | 2013-06-12 |
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| CN 201210362813 Expired - Fee Related CN102836093B (en) | 2012-09-26 | 2012-09-26 | Facial cream containing type I collagen |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014191056A1 (en) * | 2013-05-31 | 2014-12-04 | Laboratoires Inneov | Combination of active agents for treating skin aging |
| CN103800401B (en) * | 2014-02-25 | 2016-08-17 | 苗相臣 | Granulation promoting healing ointment |
| CN107375032B (en) * | 2017-08-11 | 2021-02-19 | 天津嘉氏堂科技有限公司 | Composition for repairing skin barrier and preparation method thereof |
| CN108619018B (en) * | 2018-05-14 | 2020-10-02 | 杨森 | Skin barrier repair cream and preparation method thereof |
| CN110327080B (en) * | 2019-07-05 | 2021-11-19 | 上海应用技术大学 | Skin allergy detection method and application of fingered citron essential oil and/or hydrolat |
| CN112107504A (en) * | 2020-09-24 | 2020-12-22 | 成都维德医疗器械有限责任公司 | Preparation method of modified type I collagen gel |
| CN117503658B (en) * | 2023-12-05 | 2024-06-18 | 广东丸美生物技术股份有限公司 | Multi-effect composition containing recombinant collagen and preparation method and application thereof |
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| CN102018632A (en) * | 2010-12-15 | 2011-04-20 | 广州潮徽化工科技有限公司 | High-efficiency moisturizing composition and preparation method and application thereof in cosmetics |
| CN102048666A (en) * | 2010-11-26 | 2011-05-11 | 新时代健康产业（集团）有限公司 | Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof |
| CN102085168A (en) * | 2011-01-26 | 2011-06-08 | 珠海市时代经典化妆品有限公司 | Anti-aging cosmetic |
| CN102178617A (en) * | 2011-05-09 | 2011-09-14 | 刘佩华 | Protein skin care products having function of skin repair and care |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048666A (en) * | 2010-11-26 | 2011-05-11 | 新时代健康产业（集团）有限公司 | Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof |
| CN102018632A (en) * | 2010-12-15 | 2011-04-20 | 广州潮徽化工科技有限公司 | High-efficiency moisturizing composition and preparation method and application thereof in cosmetics |
| CN102085168A (en) * | 2011-01-26 | 2011-06-08 | 珠海市时代经典化妆品有限公司 | Anti-aging cosmetic |
| CN102178617A (en) * | 2011-05-09 | 2011-09-14 | 刘佩华 | Protein skin care products having function of skin repair and care |
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