CN103800401B - Granulation promoting healing ointment - Google Patents

Abstract

The present invention relates to a kind of external mineral and plant ointment, i.e. granulation promoting healing ointment.Trade name: granulation promoting jade closes cream.Granulation promoting healing ointment is made up of the raw material of following weight: Oleum sesami, life power element, vitamin E, trehalose, allantoin, Cera Flava, glycerol, calcium hydroxide.Through to 100 empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, red flood, chilblain, the dermatosis crowd such as chap use, total effective rate 96%.

Description

Granulation promoting healing ointment

Technical field:

The present invention relates to a kind of external mineral and plant ointment, i.e. granulation promoting healing ointment.Trade name: granulation promoting jade closes cream.

Background technology:

In the prior art, medically, dermatosis is the disease about skin, has a strong impact on people's health One of commonly encountered diseases, frequently-occurring disease, as empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, Eczema, red flood, chilblain, chap, pruritus, decubital ulcer, the dermatosis that diabetes etc. cause.Dermatosis is that skin is by internal and external factor After impact, its form, 26S Proteasome Structure and Function all change, produced pathological process, and produce various clinical manifestation accordingly.By In the change of natural environment and variation of ecology and environment, atmosphere pollution and dietary structure, cause the tight of human body mine trace element Weight is unbalance, and the sickness rate of dermatosis is more and more higher, the most unhealthful and quality of life, severe one threat to life.Existing market The hormones of upper treatment dermatosis, chemical classes, Chinese medicine class medicament categories are various, though prescription is different, but curative effect is poor, secondary work With many, it has also become the common fault of said medicine.

Summary of the invention

The purpose of the present invention: be that the one provided for above-mentioned deficiency includes saccharide, protein, fat, vitamin, life Life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. kind more than 20 Mine trace element) five big basic nutrition key elements, curative effect is good, has no side effect without any, can treating both the principal and secondary aspects of a disease novel outside Use mastic preparation.To empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, red Flood, chilblain, chap, the dermatosis of the initiation such as decubital ulcer, diabetes has notable treatment and curative effect.

The technical solution of the present invention is: granulation promoting healing ointment, and the raw material including following weight is made: Oleum sesami 150- 250 grams, life power element 10-25 gram, vitamin E 5-15 gram, trehalose 10-30 gram, allantoin 1-5 gram, Cera Flava 2- 10 grams, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram.

Granulation promoting healing ointment, the raw material including following weight makes: Oleum sesami 150-250 gram, life power element 10-25 Gram, vitamin E 5-1.5 gram, trehalose 10-30 gram, allantoin 1-5 gram, 2-10 gram of Cera Flava, glycerol 30-50 gram, hydrogen-oxygen Change calcium 0.5-1.0 gram, stearic acid 10-20 gram, monoglyceride 10-20 gram, C16-18 alcohol 10-20 gram, emulsifying agent A-165 10-20 gram, propylene glycol 30-50 gram, dimethicone 5-15 gram, MAPK-50 emulsifying agent 30-50 gram, propylparaben 0.5-1.5 gram, Methyl p-hydroxybenzoate 1-2 gram, 1-2 gram of essence, LGP antibacterial 1.0-2.0 gram, deionized water 450-700 gram.

A kind of preparation method of granulation promoting healing ointment, its step is as follows:

(1) raw material:

A phase: Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, propylene glycol, Propylparaben.

B phase: deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying agent.

C phase: life power element, vitamin E, LGP antibacterial, essence.

(2) step:

A phase, B phase, the various raw and auxiliary material of C phase being weighed the most successively, by A phase, B phase is respectively implanted after weighing Heating in water bath in oil, kettle, all dissolves biphase to A, B, stirs, A phase put and first enter in vacuum emulsifying pot, then B phase being slowly added in A phase, heating in water bath, stirring, homogenizing, emulsifying in vacuum emulsifying pot, emulsifying temperature is 85 degree, Insulation emulsification times is 20 minutes.

By when mastic temperature drops to 65 degree in pot, then C phase is slowly added into stirring, homogenizing in A, B phase, after stirring i.e. Can stop；When mastic temperature drops to 35 degree, close vacuum homogeneous emulsifying machine, stand 24 hours, obtain granulation promoting healing ointment.

Fang Xie: granulation promoting healing ointment is with life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg Magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element), vitamin E, trehalose, allantoin, calcium hydroxide, Oleum sesami, Cera Flava, glycerol etc. are primary raw material, with heat-clearing and toxic substances removing, and reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting, Drive away the poison that becomes silted up, improve skin pruritus and microcirculation disturbance, supplement human body necessary (saccharide, protein, fat, vitamin, ore deposit Material) five big basic nutrition key elements, to repair damaged cell tissue, promote skin tissue cell regeneration, raising skin is disease-resistant and exempts from Epidemic disease ability is the principles of formulating prescriptions, uses modern mastic processing technology to refine and forms.

Primary raw material:

1. life power element: Jinshan Ecological Power Element Manufacture Co., Ltd., Beijing's commercially product.Include (Zn zinc, Fe ferrum, Ca Calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element), be China Famous quantum chemist, the most famous rheology phase scholar, the present age, group's discussed the outstanding representative of statistical mechanics, Jin Riguang Teaching according to JRG-Fourth statistics theoretical, use high-new rheology phase technology, the pioneering one developed and invent embodies life completely Life kinetics and the upper state prepared, H.D water-complex ion group's concentrated solution, through Ministry of Land and Resources tissue national level Expert testimony, participate in evaluation have the Chinese Academy of Sciences, Chinese Academy of Geological Sciences, China Preventive Medicial Science Institute, State Bureau of Environmental Protection, The expert of the academician of the unit such as the Ministry of Agriculture, Beijing Sanitary and Antiepidemic Station, professor, expert and the United Nations Industrial Development Organization unanimously recognizes The life sciences new and high technology of domestic initiation, the leading level in the world is belonged to for " life power element " achievement.

Life power element is from Nantural non-toxic "dead" non-co-crystal formation igneous rock stone, uses high-new rheological technique to extract Mine trace element concentrated solution, life power element include (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element), it derives from natural crystal in time immemorial, lacks these elements, Inside of human body will disequilibrium, cause the generation of various disease.Life power element is that maintenance body normal physiological function can not Lack important nutrient, there is catalysis, activate life power effect, upper state and high activity can be kept for a long time, to life entity Have and act on as follows:

(1) catalyzing activation effect, life power element self catalysis, under activation, not only can with infracortical not Saturated fat effect, generates ecological oxygen, and self also can generate ecological oxygen.Play sterilization, sterilization, antiinflammation, effectively The various diseases of regulation skin.

(2) decomposing, purifying effect, life power element generates hydroxyl radical free radical and high oxidation effect, causes many Elements Atom Transferred free radical reacts, and can crack total root organic peroxy free radical of human senility.

(3) improve immunity, possess prerequisite four conditions of enhancing immune function of human body, quantum condition, Complexation conditions, magnetization condition, reactive conditions.

Life power element biological function:

Ferrum element (Fe): 1. ferrum is the important component of hemoglobin, participates in transport and the storage of oxygen.2. ferrum participates in metalloenzyme Synthesis, strengthen enzyme activity.The most directly participate in energy metabolism.4. iron deficiency can cause immune dysfunction and dermatosis.

Copper (Gu): the constituent of the most kinds of enzymes, participates in metabolic process.2. participate in hematopoiesis and the metabolism of ferrum. 3. have antioxidation and Detoxication, stimulate, induce body synthesize Gu/Zn-SOD metallothionein, participate in trace element absorption, Transhipment, and have the effect releasing heavy metal toxicity.The most directly participate in energy metabolism.5. affect skeleton, cardiovascular system and connective The metabolism of tissue.6. affect central nervous system.7. copper is to collagen protein combination and regulation sebum secretion effect.

Zinc element (Zn): 1. participate in synthesis and the performance of activity of multiple enzyme, relevant with the activity of internal more than 300 kinds of enzymes, Play a role by participating in the synthesis of the important enzymes such as archaeal dna polymerase, RNA polymerase, lactic acid dehydrogenase, directly participate in vivo protein Normal synthesis with nucleic acid and metabolism.2. promote the growth of sexual organ.3. promote normal differentiation and the growth of cell.4. participate in and Affect immunologic function.5. affect metabolism and vision, the sense of taste of vitamin.6. pair cell membrane has Stabilization.7. zinc can improve Skin resistance, treatment dermatitis, suppression psychentonia, regulation sebum secretion, malnutrition type chronic skin ulcer.8. acne, Vitiligo, herpetic dermatitis, psoriasis are all relevant with zinc deficiency.

Manganese element (Mn): 1. be important component and the activator of multiple enzyme, is also superoxide dismutase SOD, particularly The important composition composition of Mn-SOD, can remove free radical, protect cells from radical damage, be archaeal dna polymerase, flavin swash Enzyme, creatine kinase, the activator of pyruvate kinase, directly participate in protein, nucleic acid, glucose, the metabolism of fat and vitamin B1, vitamin C, the synthesis of vitamin E.2. affect reproductive function and growth promoter, 3. improve body hemopoietic function.4. promote bone The growth promoter of bone.Manganese has promotion cellular metabolism and skin and natural on-off cycles of hair growth function.

Element (Mo): 1. be the constituent of multiple enzyme, plays catalysis and Detoxication in metabolic process.2. prevent for cancer Disease and cardiovascular disease.3. relevant with hemopoietic function, anemia and tumor patient constituent content are all notable on the low side than Healthy People.

Calcium constituent (Ca): 1. be to constitute skeleton and the important component of tooth.2. it is the ultimate constituent of general soft tissue. 3. help blood coagulation, thrombinogen can be activated, be the activator of multiple enzyme, be one of the key factor of blood coagulation.4. calcium deficiency Can cause immune dysfunction, 5. calcium has removing toxic substances, suppression psychentonia effect.

Magnesium elements (Mg): have promotion metabolite excretion, collagen protein synthesis, moisturizing, protection Skin Cell, regulation pH value to make With.

Titanium elements (Ti): have defying age, regulates immunization.

Ge element (Ge): have mutation, remove free radical, regulation immunity, antiviral, antiinflammatory, defying age, contract skin Effect.

Selenium element (Se): control inflammation, prevent skin aging effect, be improved human body immunocompetence, has an opposing huge sum of money Belong to harm effect.

In sum: life power element water-complex ion not only has and automatically generates ecological oxygen (O), hydroxyl radical free radical (OH) and cracking peroxylradicals, kill the various antibacterials and virus grown on a skin surface.Decompose and get rid of skin In various harmful substances, remove the characteristic of superoxide radical in skin tissue；But also there is active cell tissue, promote cell Metabolism, acceleration nucleic acid and collagen protein synthesis, regulation immunity, slow down aging, improve human disease resistance and diseases prevention, cure the disease Function.Life power element is not only a kind of natural wound healing agent and antibacterial, but also is a kind of rare cell Nutrient and immunostimulant.Appropriate supplementary life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg Magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element), promote human body mine trace element balance, one surely Reduce the generation of various dermatosis.Damaged skin is allowed to become beautiful, moist and to recover elastic and healthy skin quality.

2. Oleum sesami: sweet in the mouth, property are flat, nontoxic；Return meridian of Hand-YANG MING.Function with cure mainly: moistening dryness for relaxing bowels, detoxification sore treatment, granulation promoting. Controlling dryness of the intestine constipation, ascarid, abdominal pain due to retention of food, skin ulcer swells, ulcer, scabies, chapped skin.

(1) " Japan hanako materia medica ": " old oil soft extracts, granulation promoting puts on flesh, pain relieving, subduing inflammation, mends rhagades of the skin.”

(2) " Bencao Jingshu ": " Oleum Sesami, sweet cold and sliding profit, therefore main retention of placenta and profit large intestine；Survivor's gas is colder, can solve Poison, removing heat from blood, therefore skin ulcer of rubbing swells ".

(3) " not Lu ": " profit large intestine, afterbirth does not falls.Survivor's skin ulcer of rubbing swells, raw alopecia ".

(4) " detailed outline ": " relieving heat toxin, food poison, insect poison "." raw with it, have moisturize, detoxify, pain relieving, the merit of detumescence, it appears that tremble with fear And ".

(5) " a thousand pieces of gold is not recorded ": " decaptitate seborrheic dermatitis ".

(6) " legendary god of farming's book on Chinese herbal medicine ": Oleum sesami sweet in the mouth, main damaging the spleen and stomach void is won, in mending five, physical strength profiting, long muscle, fill out marrow brain, take for a long time Make light of one's life by commiting suicide and do not forget.

Modern pharmacology research shows, Semen Sesami main body of oil is the unsaturated fatty acids such as oleic acid, linoleic acid, Palmic acid (83%-90%)；Rich in folic acid, nicotinic acid, protein, aminoacid, sesamin, lecithin and the material such as calcium, ferrum, there is abundant dimension Raw element A, E and B etc., wherein vitamin E is natural inhibitor, has antioxidation.Containing useful to human body in Oleum sesami Unsaturated fatty acid, it is often more important that the oleic acid content contained in Oleum sesami, is confirmed there is the suppression disease such as ulcer, asthma by medical science Disease, has the effect preventing skin quality deterioration, improving immunity, has thermal detoxification of dispelling, relieving constipation granulation promoting, effect of vessel softening.It addition, Effective ingredient contained by Oleum sesami has inhibitory action for wrinkle, black speck, xerosis cutis etc..Oleum sesami can promote muscle raw Long, scorching for chronic forms, peripheral nerve paralysis is effective in cure, it is used for treating thrombocytopenic purpura and hemorrhagic illness has one Determine effect.Described in U.S.'s shellfish thunder " oil chemistry and technology " book: pure Oleum sesami can also be widely used in external preparation for skin medicine In make emollient and medical components carrier.

3. vitamin E: vitamin E (Vitamin E) is a kind of fatsoluble vitamin, is natural antioxidant, is dissolved in In the organic solvents such as fat and ethanol, modern study shows, vitamin E can make end slightly vasodilation, improves blood circulation.

(1) vitamin E is a kind of strong oxidizer, can effectively stop becoming sour of fatty acid in food and digestive tract, can prevent The only oxidation of fatty compound, protects cells from the injury of the harmful substance that unsaturated fatty acids acid oxidase produces.

(2) vitamin E is fabulous free radical abluent, biomembrane can be protected to attack from free radical, it is possible to effectively Defying age.Protection skin.

(3) immunity of organisms is improved.

(4) protect the integrity of erythrocyte, promote the biosynthesis of erythrocyte.

(5) it is the required promotive factor of Cellular respiration, lung tissue can be protected from air pollution.

(6) prevention cardiovascular and cerebrovascular disease.

(7) requisite a kind of material during vitamin E is human body, but in pruritus serum, the content of vitamin E ratio is normal People substantially reduces.Therefore, vitimin supplement E can maintain its normal contents in human body, thus recover human body for want of it and Some dysfunction produced, and and then psoriasis is played therapeutical effect.

(8) pruritus also exists microcirculatory obstacle, and vitamin E can improve this obstacle, and pruritus is played therapeutical effect.

(9) pruritus vitamin A in the patient reduces, and vitamin A is easily oxidized in human body.Vitamin E Because more oxidized than vitamin A is easier to, so to sacrifice oneself, vitamin A can be played a protective role.Additionally, dimension is raw Element E can also protect multiple unsaturated fatty acid, makes them not oxidized, so that internal oxygen-derived free radicals reduces (pruritus patient Internal oxygen-derived free radicals increases), make cell membrane from the infringement of oxygen-derived free radicals, and then can reach treat pruritus protection healthy Effect.

4. trehalose: (the also referred to as sugar of life) is a kind of natural saccharide, is present in many desert plants, is by two The nonreducing sugar that glucose molecule is constituted with glycosidic bond, self property is highly stable, and has various bioactivators Magical protective effect.Trehalose has the protective effect of mystery to organism, be because trehalose at high temperature, high and cold, high ooze Thoroughly can form the protecting film of uniqueness under the severe environmental conditions such as pressure and dry dehydration at cell surface, protected protein matter is divided effectively Sub-invariance inactivates, thus the life process of the body that sustains life and biological characteristic.The functional characteristic of this uniqueness so that trehalose In addition to can be as the excellent activity protective agent of pharmaceutical grade protein, enzyme, vaccine and other biological goods, also it be to maintain cell Activity, the important component of skin-moisturizing, skin.

5. allantoin: allantoin is a kind of white crystals body extracted from plant, for amphoteric compound, dissolves in hydrogen-oxygen Change sodium. allantoin saturated aqueous solution shows faintly acid, and pH value is 5.5.Allantoin was once referred to as counter-stimulus, and it has weak local Paralysis effect, can effectively alleviate the stimulation of stimulus object. and it is also a kind of antioxidant simultaneously, raw with some other water soluble vitamin Ability and the vitamin C of element its set free radical the same are similar, so the oxidation resistance of cell can be strengthened. and U.S. FDA will It is classified as a first kind packet point skin protectant efficiently alive, its avirulence, nonirritant, also ametaboly reaction.Have in terms of medicine Promote the physiological functions such as cell growth, quickening wound healing, horny layer softening albumen, be that the good consolidant of skin trauma is burst with anti- Infections medicament.Can be used as alleviating and treatment xeroderma, scaling skin illness, skin ulcer, digestive tract ulcer and inflammation.Due to Allantoin is a kind of amphoteric compound, can form double salt in conjunction with many kinds of substance, has lucifuge, sterilization and anticorrosion, pain relieving, antioxygen are turned into With, skin can be made to keep moisture content, moisten and soft.

6. Cera Flava: nature and flavor with return through: sweet, tepor.Return spleen channel.Function with cure mainly: removing toxic substances, sore, granulation promoting, pain relieving.External In ulcer being unable to heal, ecthyma is rotten to the corn, wound ulceration, burn and scald.Usage and consumption: suitable amount used externally, affected part is applied in fusing；Often it is made excipient Agent and ointment bases.

7. calcium hydroxide: calcium hydroxide, chemical formula is Ca (OH)₂.Loose white powder, calcium hydroxide is slightly soluble in water, There is stronger alkalescence；The dissolving DEG C of calcium hydroxide is 0.166 gram/100 grams water when 20 DEG C, is dissolved in acid, ammonium salt, glycerol, difficult Being dissolved in water, insoluble in alcohol, calcium hydroxide claims Calx or slaked lime, and the aqueous solution of its clarification is calcium hydroxide aqueous solution." solar corona Son book on Chinese herbal medicine ": granulation promoting is put on flesh, hemostasis.

Modern medicine proves: calcium hydroxide has astringing to arrest bleeding, antibacterial antisepsis.Mucosa wound surface can be made to form thin film, Both can prevent external irritant, and bacterial reproduction can have been suppressed again to have protective effect, pathogen is had stronger killing action.

(1) permeability of blood capillary can be lowered, inflammation swelling is had preventive and therapeutic effect.

(2) dense DEG C of calcium ion can be increased in blood, make blood vessel fine and close, prevent blood plasma from oozing out, promote blood coagulation, and energy Directly contract skin blood vessel, has anastalsis.

(3) oozing out of mucosal surface secretions can be reduced, have astriction.

(4) the comprehensive various acids of energy, absorb poison, have itching-relieving action.

(5) have dispersing swelling and dissipating binds, wet, anti-inflammatory analgetic, erosion wart treatment skin ulcer effect is held back in hemostasis.

Nature and flavor with return through: pungent, warm；Poisonous.Return liver, spleen channel.

Function with cure mainly: dampness, parasite killing, hemostasis, analgesic therapy, erosion dislike meat.Control scabies, eczema, wound hemorrhage, the burning hot wound of soup, Hemorrhoid, proctoptosis.Removing dampness sore: for burn due to hot liquid or fire.Hemostasis: for traumatic hemorrhage.

Erosion nevus: for melanotic nevus.Nature and flavor and usage: suitable amount used externally.Do not take orally.It is mainly used in scald, traumatic hemorrhage.

8. glycerol: also known as glycerol, is a kind of colourless or slightly yellow clear viscous liquids, nontoxic, odorless, non-corrosiveness, There is stronger hygroscopicity, multiple esters can be generated with mineral acid and organic acid reaction, polymerization can be formed under certain condition sweet Oil.It is skin moisturizing wetting agent, skin horny layer can be penetrated into and absorb moisture, moisture is locked in intercellular substance, and allocates in good time Moisture needed for skin, long period maintenance skin optimum moisture content.Ichthyosis patient is due to sebaceous gland, sweat gland severe atrophy, institute The sebum of secretion, perspiration can not moisten and moistening skin effectively, and the clear squama of medicine desilting also has one to the secretion of sebaceous gland Fixed inhibitory action, glycerol is optimal by the dilution proportion of (1:20), the beneficially moisturizing of skin.

9. propylene glycol: propylene glycol be unsaturated polyester (UP), epoxy resin, polyurethane resin important source material, propylene glycol Viscosity and good hygroscopicity, and nontoxic, thus in food, medicine and cosmetics industry, it is widely used as hygroscopic agent, antifreeze, profit Lubrication prescription and solvent.In the food industry, propylene glycol and fatty acid response generate methyl glycol fatty acid ester, are mainly used as food emulsifying Agent；Propylene glycol is the fine solvent of flavoring agent and pigment.Propylene glycol is commonly used for manufacturing all kinds of ointment, ointment in medical industry Solvent, softening agent and excipient etc., owing to propylene glycol and all kinds of spice have preferable intersolubility, thus also serve as the molten of cosmetics Agent and softening agent etc..Propylene glycol also serves as Nicotiana tabacum L. humidizer, antifungus agent, and the aqueous solution of propylene glycol is effective antifreeze.

10. stearic acid: formal name used at school: octadecanoid acid.Satisfied fatty acid containing 18 carbon atoms.It is to constitute animal and plant oils and fats A kind of main component.Can be used for the products such as pharmaceutical preparation, ointment, soap and suppository.

11.C16-18 alcohol: be that to belong to natural fatty alcohol be also a kind of emulsion stabilizer.In medicine ointment, fragrance is pure, Essence consumption can be reduced.It it is the raw material of medicine ointment.

12. glyceryl monostearates: glyceryl monostearate is to carry out with glycerol containing C16-C18 long-chain fatty acid Esterification and prepare.It it is the surfactant of a kind of nonionic.It existing hydrophilic have again lipophilic group because of, there is moistening, breast The several functions such as change, foaming.This product is milky ceraceous solid, dissolves in methanol, ethanol, chloroform, the solution such as acetone and ether. It is emulsifying agent and the additive of food;Cosmetics and medicine unguentum are used as emulsifying agent, make mastic fine and smooth, lubricious.

13. emulsifying agent A-165: or claim tristerin/PEG-100 stearic acid ester, Guangzhou Fei Rui Chemical Co., Ltd. Commercially.Being nonionic self emulsifying monoglyceride, emulsifying capacity is strong, is O/W emulsifying agent.Can be used alone or make co-emulsifier.Have Certain from thickening property, the either mastic of emulsion or thicker, it has splendid stability.To polarity and nonpolar oils and fats all Energy emulsifying, and the mastic outward appearance exquisiteness malleability bright, auxiliary that emulsifying is out is good, easily smears, and what imparting product was the most comfortable smears spy Property, effectively play functional component.Use compounding with MONTANOV series emulsifying agent, i.e. can reach satisfied effect.

14.MAPK--50 emulsifying agent: chemical name: 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium salt, transparency liquid or white paste, safety Low stimulation, structure is similar to natural phospholipid, and character is gentle, is preferable cream emulsifying agent；Excellent emulsifying, solubilising and dispersibility Energy；Relatively low surface tension, foaming abundancy is fine and smooth；Excellent moist performance；Salt tolerant, acid-proof alkaline are excellent；Water solublity is good Good, can be used for cold dispensing；Good biological degradability, is particularly well-suited to prepare foam facial milk cleanser and foam face cleaning curry, various The infant nursing product of shampoo, bath gel, handwashing liquid, and gentleness.

15. dimethicones: another name methyl-silicone oil, polysiloxanes, dimethicone, silicone oil, have physiological inertia, good Good chemical stability, electricity edge and weatherability, viscous DEG C scope is wide, and freezing point is low, and flash-point is high, and hydrophobic performance is good, and has very High shear resistance.Human body without toxigenicity, is not decomposed by dimethicone by body fluid, therefore in medical and health care system, also by Extensively application.Utilize its froth breaking effect, be made for oral gastrointestinal flatulence relieving tablet, and pulmonary edema froth breaking aerosol etc. is medicinal.At ointment Middle addition silicone oil, can improve the penetrating power of pharmaceutical through skin, improves drug effect.Based on silicone oil, some plaster of oil is to scalding Wound, dermatitis, decubital ulcer etc. have good curative effect, utilize the blood coagulation resisting function of silicone oil, and available its processes storage blood device surface, extends blood Sample period of storage etc..It is alternatively arranged as condom wet type lubricant, and its not Killing Sperm.Cosmetics add silicone oil can improve Skin is moistened and protective effect etc..

16. propyl p-hydroxybenzoate: also known as propylparaben, white crystalline powder, are soluble in alcohol and ether, in water The most insoluble, it is mainly used as food, cosmetics, the sterilization antiseptic of medicine.

17. ethylparabens: also known as ethyl hydroxybenzoate, colourless fine crystalline or crystalline powder, almost odorless, Slightly astringent taste, to light and thermally stable, no hygroscopicity, 1g this product is about dissolved in 1340mL, the water of 25 DEG C, 1.4mL propylene glycol and 100mL Oleum Arachidis hypogaeae semen, is mainly used as food, cosmetics, medicine sterilization antiseptic.

18. Sang Pu LGP antibacterial: liquid, chemical name: 1,3-dihydroxymethyl-5,5-dimethyl hydantoin, IPBC, butanediol.Broad spectrum antibiotic activity, can effectively suppress gram negative bacteria, positive bacteria, yeast and mycete, mainly apply In cosmetics, medicine cream, dew liquid, hair care category, sunscreen products, baby products, eye cosmetic, the sterilization antiseptic of wet paper towel.

19. deionized waters: refer to the pure water after eliminating in ionic species impurity.

Granulation promoting healing ointment function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting, drives away Become silted up poison, improves skin pruritus and microcirculation disturbance, repairs damaged skin cell tissue, promotes skin tissue cell regeneration, improves Skin is disease-resistant and immunocompetence, supplements the big basic battalion of human body necessary (saccharide, protein, fat, vitamin, mineral) five Support key element.Be mainly used in treatment: empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, Eczema, red flood, chilblain, the dermatosis such as chap.

Specification: 15 grams 30 grams 50 grams, one, every box.

Using method: external, is applied to affected part, general patient, and every day is early, middle and late the most once；Empyrosis, traumatic injury, Eczema, chilblain patient, be uniformly applied to wound surface by ointment, and thickness, at about 1mm, is smeared once in every 2 hours, will with ointment when changing dressings On wound surface, left drug and liquefied substance are wiped away, the most as stated above smearing ointment, wound surface incrustation after will at incrustation surface And around smearing ointment, until incrustation Automatic-falling generates new skin, neoplastic skin surface and around to continue to smear medicine Cream, wound surface exposes medication best results, thin out until neoplastic skin surface color or close to after normal skin color by every day early, In, evening respectively once smear, recover can discontinue medication after normal skin quality until skin, skin is beautiful, moist, flexible more afterwards, nothing Pigmentation, without cicatrix.

The invention have the advantage that

1, granulation promoting healing ointment is with life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo, Ti titanium, Mg magnesium, Sr Strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element) centered by metal ion, form most preferably with 6～7 hydrones Various effective ingredient can be become with micro-magnetic moment, upper state, Thief zone, multi-functional short chain linear junction by water-complex ion Structure water-complex ion group.Its hydrodynamic radius is 0.1nm, simply the 0.1%～1% of human body cell, due to associated water molecules Spend the least, be very easy to through skin surface cell film, will be with positive charge, d track, the life power of micro-magnetic moment is plain and various Effective ingredient, directly brings in the organizational structure of Skin Cell and enzyme, participates in biochemical reaction.Contained by various trace element Water complex ion and the effect of enzyme, supplement rapidly (Zn zinc, Mn manganese, Gu copper, Fe ferrum, Mo relevant to life in organism , Co cobalt, Ti titanium, Mg magnesium, Ca calcium, Sr strontium, Ge germanium, Rb rubidium, K potassium, Na sodium, Si silicon, B boron, Se selenium, the mineral trace such as I iodine unit Element) and various nutrient substance, repair damaged skin cell, promote skin cell metabolism, acceleration nucleic acid and collagen protein Synthesis, reaches to recover skin regeneration ability with this, allows skin recover elastic and healthy purpose.Granulation promoting jade closes another characteristic of cream It is to utilize life power element water-complex ion group to automatically generate ecological oxygen (O) and the characteristic of hydroxyl radical free radical (OH), kills Grow the various antibacterials on human body skin and virus, decompose and get rid of various harmful substance, and then reach " to prevent skin sense Dye, promote skin regeneration, eliminate skin pruritus, recover skin health " purpose.

2, granulation promoting jade closes cream obvious novelty on prescription and processing technology, and mastic is fine and smooth, soft, stretchability is good, nothing Abnormal flavour, safe and reliable, therapeutic effect is satisfactory, is the medical ointment of a kind of reasonable external curing dermatosis.

3, through to 100 empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, wet Rash, red flood, chilblain, the dermatosis crowd such as chap use, total effective rate 96%.

Below in conjunction with embodiment, embodiments of the present invention are described in further detail.

Detailed description of the invention

Embodiment 1

Granulation promoting healing ointment, the raw material including following weight makes: Oleum sesami 200 grams, life power element 20 grams, vitamin E 10 grams, trehalose 25 grams, allantoin 5 grams, 5 grams of Cera Flava, glycerol 50 grams, calcium hydroxide 1 gram.

Embodiment 2

Granulation promoting healing ointment, the raw material including following weight makes: Oleum sesami 200 grams, life power element 20 grams, vitamin E 10 grams, trehalose 25 grams, allantoin 5 grams, 5 grams of Cera Flava, glycerol 50 grams, calcium hydroxide 1 gram, stearic acid 10 grams, monoglyceride 15 grams, C16-18 alcohol 15 grams, emulsifying agent A-165 15 grams, propylene glycol 50 grams, dimethicone 10 grams, MAPK-50 emulsifying agent 35 grams, Buddhist nun Moor 1 gram of golden third fat, Methyl p-hydroxybenzoate 1.5 grams, 1.5 grams of essence, LGP antibacterial 2 grams, deionized water 528 grams.Make 1000 grams of cream Body.

Note: calcium hydroxide can make aqueous solution.

Or calcium hydroxide can be when 20 DEG C, add the proportions of 100 grams of deionized waters by 0.17 gram of calcium hydroxide Calcium hydroxide aqueous solution, is sufficiently stirred for, dissolves, stands, to take supernatant standby.

Embodiment 3

Granulation promoting healing ointment production technology:

A phase (oil phase): Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, Propylene glycol, propylparaben.

B phase (aqueous phase): deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying Agent.

C phase: life power element, natural Vitamin E, LGP antibacterial, essence.

(1) A phase, B phase, the various raw and auxiliary material of C phase are weighed the most successively,

(2) by A phase, B phase is respectively implanted heating in water bath in oil, kettle after weighing, and all dissolves biphase to A, B, and stirring is all Even, A phase is put and first enters in vacuum emulsifying pot, then B phase is slowly added in A phase, water-bath in vacuum emulsifying pot Heating, stirring, homogenizing, emulsifying, emulsifying temperature is 85 degree, and insulation emulsification times is 20 minutes.

By when mastic temperature drops to 65 degree in pot, then C phase is slowly added into stirring, homogenizing in A, B phase, after stirring i.e. Can stop；When mastic temperature drops to 35 degree, close vacuum homogeneous emulsifying machine, stand 24 hours, obtain granulation promoting healing ointment.

(3) inspection of semifinished product.(4) fill.(5) packaging.(6) examination and test of products.(7) finished product warehouse-in.

Experimental example

Clinical experiment case:

Granulation promoting jade closes cream 100 example Clinical practice visual report-Army Hospital of the Chinese People's Liberation Army 65571

According to the requirement of trustee, my institute establishes sensitive, exclusive, accurate clinical using method, is provided trustee Given the test agent carry out actual clinical inspection, from January, 2012--in January, 2013, special at my institute's dermatosis training and burn and scald Section, by granulation promoting jade conjunction cream be used for " empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, Eczema, red flood, chilblain, chap " etc. dermatosis crowd " amount to 100 example experimenters, through 30 days (course for the treatment of usage amount) Clinical observation, therapeutic effect is satisfied, existing by as follows for tested crowd's physical record effect report:

For observing product standard specimen character standard specimen: it is medicinal plastic tube packaging that granulation promoting jade closes cream, and every fills 30 grams of mastic, close Envelope is good, amounts to 600.The milky white exquisiteness of mastic, good fluidity, stretching are good, and transdermal characteristic is good, Water-In-Oil mastic, have light sesame Spicy hot taste, after wiping, skin is comfortable, soft, silk cunning, nonirritant, safe and reliable.

Product prescription: granulation promoting jade closes cream standard specimen (embodiment 2 formula).

Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting.

It is mainly used in empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, wet Rash, red flood, chilblain, the treatment of the disease such as chap.

Clinical case ordinary circumstance and standard formulation: the diagnostic criteria of the MHO world is pressed in experiment, experimental group is in voluntary, feelings of knowing the inside story Under condition, the dermatosis experimenter that on-demand 100 Li Lai institutes are medical, minimum 18 years old of age, maximum 64 years old；Administration time unification is with 30 It is limited, and formulates treatment standard: 1. empyrosis patient, hinders that face inflammation disappears, blister stops oozing out for effectively (skin crust is stable), Hinder flushing swollen disappear, neoplastic skin generates, more after be effective (cutting crust) without cicatrix；It is otherwise invalid.2. other patients, skin table Face transference cure, redness disappear, pore recovers normally, skin smooth is effective, and it is effective that symptom becomes the lighter.It is otherwise invalid.

Therapeutic modality: every example 1 part, is used alone granulation promoting jade and closes cream treatment dermatosis by 6 every part.

Observing patient's number altogether is 100 examples, and total effective rate is 96%

Conclusion: the granulation promoting jade conjunction modern mastic manufacturing technology of cream application is refined to be formed, and standard specimen additionally shows: granulation promoting jade closes Cream includes: life power element (mine trace element concentrated solution), vitamin E, trehalose, allantoin, calcium hydroxide, Oleum sesami, Cera Flava, glycerol etc. are raw material.Examining report shows, granulation promoting jade conjunction cream is to rabbit no skin irritation, to guinea pig skin without sensitization Property, qualified to rat skin avirulence, physics and chemistry and microbial portion, granulation promoting jade close cream sample through 100 example experimenters use also without Untoward reaction.

Data shows: life power element (i.e. mine trace element concentrated solution) includes the ore deposit that kind more than 27 is relevant to human life Thing trace element, Qi Zhongxin, manganese, copper, ferrum, the metal ion such as cobalt, titanium, magnesium, strontium, germanium be to rise to urge in human body biochemical reaction Change, activation with positive charge, d track, micro-magnetic moment life power element.

Through verification: it is centered by life power element (i.e. mine trace element concentrated solution) metal ion that granulation promoting jade closes cream, Forming optimal water-complex ion with 6～7 hydrones, can become various effective ingredient with micro-magnetic moment, upper state, height oozes Thoroughly, multi-functional short chain linear structure water-complex ion group.Its hydrodynamic radius is 0.1nm, simply human body cell 0.1%～1%, owing to associated water molecules degree is the least, it is very easy to through skin surface cell film, will be with positive charge, d track, Plain and the various effective ingredient of the life power of micro-magnetic moment, directly brings in the organizational structure of Skin Cell and enzyme, participates in raw Change reaction.By the effect of various trace element water-complex ion Yu enzyme, supplement in organism rapidly relevant to life (Zn zinc, Mn manganese, Gu copper, Fe ferrum, Mo, Co cobalt, Ti titanium, Mg magnesium, Ca calcium, Sr strontium, Ge germanium, Rb rubidium, K potassium, Na sodium, Si silicon, The mine trace elements such as B boron, Se selenium, I iodine) and various nutrient substance, repair damaged skin cell, promote Skin Cell new old generation Thank, accelerate nucleic acid and the synthesis of collagen protein, reach to recover skin regeneration ability with this, allow skin recover elastic and healthy mesh 's.It is to utilize life power element water-complex ion group to automatically generate ecological oxygen (O) and hydroxyl that granulation promoting jade closes another characteristic of cream The characteristic of free radical (OH), kills the various antibacterials and virus growing on human body skin, decomposes and get rid of various nuisance Matter, and then reach the purpose of " prevent skin infection, promote skin regeneration, elimination skin pruritus, recovery skin health ".

In sum, granulation promoting jade closes cream obvious novelty on prescription and processing technology, and mastic is fine and smooth, soft, Tu Zhan Property is good, and free from extraneous odour, safe and reliable, therapeutic effect is satisfactory, is the unguentum medicine of a kind of reasonable external curing dermatosis Product.

Claims (5)

1. the granulation promoting healing ointment treating skin disease, it is characterised in that be made up of the raw material of following weight: Oleum sesami 150-250 gram, life power element 10-25 gram, vitamin E 5-15 gram, trehalose 10-30 gram, allantoin 1-5 gram, honeybee 2-10 gram of wax, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram.

2. the granulation promoting healing ointment treating skin disease, it is characterised in that be made up of the raw material of following weight: Oleum sesami 150-250 gram, life power element 10-25 gram, vitamin E 5-15 gram, trehalose 10-30 gram, allantoin 1-5 gram, honeybee 2-10 gram of wax, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram, stearic acid 10-20 gram, monoglyceride 10-20 gram, C16- 18 alcohol 10-20 gram, emulsifying agent A-165 10-20 gram, propylene glycol 30-50 gram, dimethicone 5-15 gram, MAPK-50 breast Agent 30-50 gram, propylparaben 0.5-1.5 gram, Methyl p-hydroxybenzoate 1-2 gram, 1-2 gram of essence, LGP antibacterial 1.0- 2.0 grams, deionized water 450-700 gram.

3. according to the granulation promoting healing ointment described in claim 1, it is characterised in that: Oleum sesami 200 grams, life power element 20 grams, dimension Raw element E 10 grams, trehalose 25 grams, allantoin 5 grams, 5 grams of Cera Flava, glycerol 50 grams, calcium hydroxide 1.0 grams.

4. according to the granulation promoting healing ointment described in claim 2, it is characterised in that: Oleum sesami 200 grams, life power element 20 grams, dimension Raw element E 10 grams, trehalose 25 grams, allantoin 5 grams, 5 grams of Cera Flava, glycerol 50 grams, calcium hydroxide 1.0 grams；Stearic acid 10 grams, list 15 grams of sweet fat, C16-18 alcohol 15 grams, emulsifying agent A-165 15 grams, propylene glycol 50 grams, dimethicone 10 grams, MAPK-50 emulsifying Agent 35 grams, propylparaben 1 gram, Methyl p-hydroxybenzoate 1.5 grams, 1.5 grams of essence, LGP antibacterial 2 grams, deionized water 528 grams.

5. the preparation method of the granulation promoting healing ointment as described in claim 2 or 4, it is characterised in that:

(1) raw material: A phase: Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, third Glycol, propylparaben；

B phase: deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying agent；

C phase: life power element, vitamin E, LGP antibacterial, essence；

(2) step:

A phase, B phase, the various raw and auxiliary material of C phase being weighed the most successively, by A phase, B phase is respectively implanted oil, water after weighing Heating in water bath in pot, all dissolves biphase to A, B, stirs, A phase first inserted in vacuum emulsifying pot, then by B phase Being slowly added in A phase, heating in water bath, stirring, homogenizing, emulsifying in vacuum emulsifying pot, emulsifying temperature is 85 degree, insulation breast The change time is 20 minutes；

By when mastic temperature drops to 65 degree in pot, then C phase is slowly added into stirring, homogenizing in A, B phase, can stop after stirring Only；When mastic temperature drops to 35 degree, close vacuum homogeneous emulsifying machine, stand 24 hours, obtain granulation promoting healing ointment.