CN103800401A - Granulation promoting and healing ointment - Google Patents
Granulation promoting and healing ointment Download PDFInfo
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Abstract
The invention relates to an external mineral plant ointment, namely granulation promoting and healing ointment. The commodity name is granulation promoting and healing ointment. The ointment is prepared from the following raw materials by weight: sesame oil, vital kinetic hormone, vitamin E, mycose, allantoin, bee wax, glycerinum and calcium hydroxide. Application of the ointment in 100 persons with burn and scald, traumatic injury, mosquito bite, ultraviolet injury, computer radiation, skin allergy, eczema, redness, chilblain, chap and other skin diseases proves that the total effective rate is 96 percent.
Description
technical field:
The present invention relates to a kind of external mineral and plant ointment, i.e. granulation promoting healing ointment.Trade name: granulation promoting jade closes cream.
background technology:
In the prior art, medically, dermatosis is the disease about skin class, one of the commonly encountered diseases that has a strong impact on people ' s health, frequently-occurring disease, as empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, redly flood, chilblain, chap, pruritus, decubital ulcer, the dermatosis that diabetes etc. cause.Dermatosis is that skin is subject to after the impact of internal and external factor, and its form, 26S Proteasome Structure and Function all change, the pathological process that produces, and produce accordingly various clinical manifestations.Due to natural environment and variation of ecology and environment, the change of atmosphere pollution and dietary structure, causes the serious unbalance of human body mine trace element, and the sickness rate of dermatosis is more and more higher, gently unhealthful and quality of life, severe one threat to life.Hormones, chemical classes, the Chinese medicine class medicament categories for the treatment of in the market dermatosis are various, though prescription is different, curative effect is poor, and side effect is many, has become the common fault of said medicine.
Summary of the invention
Object of the present invention: be that the one that provides for above-mentioned deficiency includes saccharide, protein, fat, vitamin, life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element) five large basic nutrition key elements, curative effect is good, have no side effect without any, the Novel external mastic preparation of energy treating both the principal and secondary aspects of a disease.To empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, redly flood, chilblain, chap, the dermatosis of the initiation such as decubital ulcer, diabetes has remarkable treatment and curative effect.
Technical solution of the present invention is: granulation promoting healing ointment, comprises that the raw material of following weight is made: Oleum sesami 150-250 gram, 10-25 gram of life power element, vitamin E 5-15 gram, trehalose 10-30 gram, allantoin 1-5 gram, Cera Flava 2-10 gram, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram.
Granulation promoting healing ointment, the raw material that comprises following weight is made: Oleum sesami 150-250 gram, life power element 10-25 gram, vitamin E 5-1.5 gram, trehalose 10-30 gram, allantoin 1-5 gram, Cera Flava 2-10 gram, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram, stearic acid 10-20 gram, monoglyceride 10-20 gram, C16-18 alcohol 10-20 gram, emulsifying agent A-165 10-20 gram, propylene glycol 30-50 gram, dimethicone 5-15 gram, MAPK-50 emulsifying agent 30-50 gram, propylparaben 0.5-1.5 gram, Methyl p-hydroxybenzoate 1-2 gram, essence 1-2 gram, LGP antibacterial 1.0-2.0 gram, deionized water 450-700 gram.
A preparation method for granulation promoting healing ointment, its step is as follows:
(1) raw material:
A phase: Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, propylene glycol, propylparaben.
B phase: deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying agent.
C phase: life power element, vitamin E, LGP antibacterial, essence.
(2) step:
A phase, B phase, the mutually various raw and auxiliary materials of C are weighed respectively in proportion successively, by A phase, B inserts respectively heating in water bath in oil, kettle after weighing mutually, by A, B is biphase all to be dissolved, stir, A is put first to enter in vacuum emulsifying pot mutually, then B is slowly added mutually A mutually in, heating in water bath, stirring, homogenizing, emulsifying in vacuum emulsifying pot, emulsifying temperature is 85 degree, and insulation emulsification times is 20 minutes.
Mastic temperature in pot is dropped to 65 while spending, then C is slowly added mutually to A, B stir in mutually, homogenizing, after stirring, can stop; Drop to 35 while spending until mastic temperature, close vacuum homogeneous emulsifying machine, leave standstill 24 hours, obtain granulation promoting healing ointment.
Side separates: granulation promoting healing ointment is with life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, Deng 20 multi mineral trace element), vitamin E, trehalose, allantoin, calcium hydroxide, Oleum sesami, Cera Flava, glycerol etc. are primary raw material, with heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting, drive away the poison that becomes silted up, improve skin pruritus and microcirculation disturbance, supplement the necessary (saccharide of human body, protein, fat, vitamin, mineral) five large basic nutrition key elements, reparation damaged cell tissue, promote skin tissue cell regeneration, improving the disease-resistant and immunocompetence of skin is the principles of formulating prescriptions, adopting modern mastic processing technology to refine forms.
Primary raw material:
1. life power element: Jinshan Ecological Power Element Manufacture Co., Ltd., Beijing business sell product.Include (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, Deng 20 multi mineral trace element), it is the famous quantum chemist of China, famous rheology phase scholar both at home and abroad, the present age, group's was discussed the outstanding representative of statistical mechanics, Jin Riguang is taught according to the 4th mechanics theory, use high-new rheology phase technology, a kind of upper state that embodies Life Dynamics completely and prepare of pioneering development and invention, H.D moisture complex ion group concentrated solution, national level expert through Ministry of Land and Resources's tissue identifies, participate in the Chinese Academy of Sciences that has of evaluation, Chinese Academy of Geological Sciences, China Preventive Medicial Science Institute, State Bureau of Environmental Protection, the Ministry of Agriculture, the academician of the units such as Beijing Sanitary and Antiepidemic Station, professor, the expert of expert and the United Nations Industrial Development Organization unanimously thinks that " life power element " achievement belongs to domestic initiation, the life sciences new and high technology of the leading level in the world.
Life power element is from the "dead" non-cocrystallizing type pyrogene rock of Nantural non-toxic, the mine trace element concentrated solution that adopts high-new rheological technique to extract, life power element includes (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element), it derives from natural crystal in time immemorial, lack these elements, inside of human body will disequilibrium, causes the generation of various diseases.Life power element is to maintain body normal physiological function can not lack important nutrient, has catalysis, activates life power effect, can keep for a long time upper state and high activity, and life entity is had to following effect:
(1) catalyzing activation effect, life power element under self catalysis, activation, not only can with infracortical unsaturated fatty acids effect, generate ecological oxygen, and self also can generate ecological oxygen.Play sterilization, sterilization, antiinflammation, effectively renovate the various diseases of skin.
(2) decomposing, purifying effect, life power element generates hydroxyl radical free radical and high oxidation effect, causes many element atom transferred free radicals reactions, total root organic peroxy free radical that can cracking human senility.
(3) improve immunity, possessed prerequisite four conditions of enhancing immune function of human body, quantum condition, complexation condition, magnetization condition, reactive conditions.
Life power element biological function:
Ferrum element (Fe): 1. ferrum is the important component of hemoglobin, participates in transportation and the storage of oxygen.2. ferrum participates in the synthetic of metalloenzyme, strengthens the activity of enzyme.3. participate in energy metabolism directly.4. iron deficiency can cause immune dysfunction and dermatosis.
Copper (Gu): the 1. constituent of plurality of enzymes, participates in metabolic process.2. participate in the metabolism of hematopoiesis and ferrum.3. there are antioxidation and Detoxication, stimulate, induce the synthetic Gu/Zn-SOD metallothionein of body, participate in absorption, the transhipment of trace element, and have the effect of removing heavy metal toxicity.4. participate in energy metabolism directly.5. affect the metabolism of skeleton, cardiovascular system and connective tissue.6. affect central nervous system.7. copper is to collagen protein combination and the effect of adjusting sebum secretion.
Zinc element (Zn): 1. participate in the synthetic and active performance of plurality of enzymes, relevant with the activity of 300 plurality of enzymes in body, play a role by participating in the synthetic of important enzyme such as archaeal dna polymerase, RNA polymerase, lactic acid dehydrogenase, participate in the normal synthetic and metabolism of the interior albumen of body and nucleic acid directly.2. promote sexual organ's growth.3. promote normal differentiation and the growth of cell.4. participate in and affect immunologic function.5. affect the metabolism of vitamin and vision, the sense of taste.6. cell membrane has Stabilization.7. zinc can improve skin resistance, treatment dermatitis, suppresses psychentonia, regulate sebum secretion, malnutrition type chronic skin ulcer.8. acne, vitiligo, herpetic dermatitis, psoriasis are all relevant with zinc deficiency.
Manganese element (Mn): the 1. important component and the activator that are plurality of enzymes; also be the important composition composition of superoxide dismutase SOD, particularly Mn-SOD; can remove free radical; Cell protection is avoided radical damage; be the activator of archaeal dna polymerase, flavokinase, creatine kinase, pyruvate kinase, participate in the synthetic of the metabolism of protein, nucleic acid, glucose, fat and vitamin B1, vitamin C, vitamin E directly.2. affect reproductive function and growth promoter, 3. improve body hemopoietic function.4. promote the growth promoter of skeleton.Manganese has the cellular metabolism of promotion and skin and natural on-off cycles of hair growth function.
Molybdenum element (Mo): be 1. the constituent of plurality of enzymes, play catalysis and Detoxication in metabolic process.2. anti-curing cancers and cardiovascular disease.3. relevant with hemopoietic function, anemia and tumor Huan person Molybdenum constituent content are all remarkable on the low side than Healthy People.
Calcium constituent (Ca): are 1. the important component that form skeleton and tooth.2. are ultimate constituents of general soft tissue.3. helping blood coagulation, can activate thrombinogen, is the activator of plurality of enzymes, is one of key factor of blood coagulation.4. calcium deficiency can cause immune dysfunction, and 5. calcium has removing toxic substances, suppresses psychentonia effect.
Magnesium elements (Mg): have the excretion of the metabolite of promotion, collagen protein synthesis, moisturizing, protection Skin Cell, regulate pH value effect.
Titanium elements (Ti): have defying age, regulate immunization.
Ge element (Ge): have the effect of mutation, removing free radical, adjusting immunity, antiviral, antiinflammatory, defying age, contract skin.
Selenium element (Se): control inflammation, prevent skin aging effect, be improved human body immunocompetence, have opposing heavy metal to harm effect.
In sum: the moisture complex ion of life power element not only has and has automatic generation ecological oxygen (O), hydroxyl radical free radical (OH) and cracking peroxylradicals, kills various antibacterials and the virus of growing on skin surface.Decompose and get rid of various harmful substances in skin, remove the characteristic of superoxide radical in skin tissue; But also there is active cell tissue, promotion cell metabolism, acceleration nucleic acid and collagen protein synthesis, adjusting immunity, slow down aging, the function of improve human body resistance against diseases and diseases prevention, curing the disease.Life power element is not only a kind of natural wound healing agent and antibacterial, but also is a kind of rare cell nutritious element and immunostimulant.The appropriate life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element) that supplements, promote human body mine trace element balance, one reduces the generation of various dermatosis surely.Allow damaged skin become beautiful, moisten and recover elasticity and healthy skin quality.
2. Oleum sesami: sweet in the mouth, property are flat, nontoxic; Return meridian of Hand-YANG MING.Function with cure mainly: moistening dryness for relaxing bowels, detoxification sore treatment, granulation promoting.Control dryness of the intestine constipation, ascarid, abdominal pain due to retention of food, skin ulcer is swollen, ulcer, scabies, chapped skin.
(1) " Japan hanako materia medica ": " old oily soft extracts, granulation promoting is put on flesh, pain relieving, subduing inflammation, mends rhagades of the skin.”
(2) " Bencao Jingshu ": " Oleum Sesami, sweet cold and sliding sharp, therefore main retention of placenta and sharp large intestine; Survivor's gas is colder, can detoxify, removing heat from blood, therefore the skin ulcer of rubbing is swollen ".
(3) not " not Lu ": " sharp large intestine, afterbirth does not fall.Survivor's skin ulcer of rubbing is swollen, raw alopecia ".
(4) " detailed outline ": " relieving heat toxin, food poison, insect poison "." raw with it, have moisturize, the merit of removing toxic substances, pain relieving, detumescence, seem to tremble with fear and ".
(5) not " a thousand pieces of gold is not recorded ": " seborrheic dermatitis of decaptitating ".
(6) " legendary god of farming's book on Chinese herbal medicine ": Oleum sesami sweet in the mouth, main damaging the spleen and stomach is empty wins, mend in five, physical strength profiting, longue meat, fills out marrow brain, and clothes are made light of one's life by commiting suicide and are not forgotten for a long time.
Modern pharmacology research shows, Semen Sesami main body of oil is the unsaturated fatty acids (83%-90%) such as oleic acid, linoleic acid, Palmic acid; Be rich in the materials such as folic acid, nicotinic acid, protein, aminoacid, sesamin, lecithin and calcium, ferrum, there is abundant vitamin A, E and B etc., wherein vitamin E is natural inhibitor, has antioxidation.In Oleum sesami, contain the unsaturated fatty acid useful to human body, the more important thing is the oleic acid composition containing in Oleum sesami, confirmed there are the diseases such as the ulcer of inhibition, asthma by medical science, there is the effect that the skin quality of preventing worsens, improves immunity, have effect of the thermal detoxification of dispelling, relieving constipation granulation promoting, vessel softening.In addition, the contained effective ingredient of Oleum sesami has inhibitory action for wrinkle, black speck, xerosis cutis etc.Oleum sesami can impel muscle growth, effective in cure for chronic neuritis, peripheral nerve paralysis, is used for the treatment of thrombocytopenic purpura and hemorrhagic illness has certain effect.In U.S.'s shellfish thunder " oil chemistry and technology " book, record: pure Oleum sesami can also be widely used in and in external preparation for skin medicine, make emollient and medical components carrier.
3. vitamin E: vitamin E (Vitamin E) is a kind of fatsoluble vitamin, is natural antioxidant, is dissolved in fat and the organic solvent such as ethanol, and modern study shows, vitamin E can make slightly vasodilation of end, improves blood circulation.
(1) vitamin E is a kind of strong oxidizer, can effectively stop becoming sour of the interior fatty acid of food and digestive tract, can prevent the oxidation of fatty compound, and Cell protection is avoided the injury of the harmful substance of unsaturated fatty acids acid oxidase generation.
(2) vitamin E is fabulous free radical abluent, can protect biomembrane to avoid free radical and attack, defying age effectively.Protection skin.
(3) improve immunity of organisms.
(4) integrity of protection erythrocyte, the biosynthesis of promotion erythrocyte.
(5) be the essential factor that promotes of Cellular respiration, can protect lung tissue to avoid air pollution.
(6) prevention cardiovascular and cerebrovascular disease.
(7) vitamin E is requisite a kind of material in human body, but in pruritus serum the content of vitamin E than the obvious reduction of normal person.Therefore, vitimin supplement E can maintain its normal contents in human body, thereby recovers for want of it and some dysfunction of producing of human body, and and then to psoriasis performance therapeutical effect.
(8) pruritus exists microcirculatory obstacle, and vitamin E can improve this obstacle, to pruritus performance therapeutical effect.
(9) in pruritus patient body, vitamin A reduces, and vitamin A is easy to oxidized in human body.Vitamin E is because of more easily more oxidized than vitamin A, so can, to sacrifice oneself, vitamin A be played a protective role.In addition; vitamin E can also be protected multiple unsaturated fatty acid, makes them not oxidized, thereby makes the oxygen-derived free radicals in body reduce (in pruritus patient body, oxygen-derived free radicals increases); make cell membrane avoid the infringement of oxygen-derived free radicals, so can reach treatment pruritus protect healthy effect.
4. trehalose: (also claiming the sugar of life) is a kind of natural saccharide; be present in many desert plants; be the nonreducing sugar being made up of with glycosidic bond two glucose molecules, self property is highly stable, and various bioactivators is had to magical protective effect.Trehalose has magical protective effect to organism; because trehalose can form unique protecting film at cell surface under the severe environmental conditions such as high temperature, high and cold, hyperosmosis and dry dehydration; protected protein matter molecule invariance inactivation effectively, thereby the life process of the body that sustains life and biological characteristic.The functional characteristic that this is unique, makes trehalose except can be used as the excellent activity protective agent of pharmaceutical grade protein, enzyme, vaccine and other biological goods, still keeps the important component of cytoactive, skin-moisturizing, skin.
5. allantoin: allantoin is a kind of white crystals body extracting from plant, is amphoteric compound, dissolves in sodium hydroxide. allantoin saturated aqueous solution shows faintly acid, and pH value is 5.5.Allantoin was once called as counter-stimulus, it has weak local paralysis effect, the effectively stimulation of abirritate thing. it is also a kind of antioxidant simultaneously, ability and vitamin C with the same its set free radical of some other water soluble vitamins are similar, so can strengthen the oxidation resistance of cell. U.S. FDA is classified as the efficient point component skin protectant of living of the first kind, its avirulence, nonirritant, also ametaboly reaction.Aspect medical, there is Promote cell's growth, accelerating wound, the physiological functions such as horny layer softening albumen, are good consolidant and the antiulcer agents of skin trauma.Can be used as alleviating and treatment xeroderma, squama skin illness, skin ulcer, digestive tract ulcer and inflammation.Because allantoin is a kind of amphoteric compound, can form double salt in conjunction with many kinds of substance, there is lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, can make skin keep moisture content, moist and soft.
6. Cera Flava: nature and flavor with return through: sweet, tepor.Return spleen channel.Function with cure mainly: removing toxic substances, sore, granulation promoting, pain relieving.Outward for ulcer being unable to heal, ecthyma erosion, wound ulceration, burn and scald.Usage and consumption: suitable amount used externally, affected part is applied in fusing; Often make excipient and ointment substrate.
7. calcium hydroxide: calcium hydroxide, chemical formula is Ca (OH)
2.Loose white powder, calcium hydroxide is slightly soluble in water, has stronger alkalescence; The dissolving of calcium hydroxide ℃ is 0.166 gram/100 grams water in the time of 20 ℃, is dissolved in acid, ammonium salt, glycerol, is insoluble in water, is insoluble to alcohol, and calcium hydroxide claims Calx or slaked lime, and the aqueous solution of its clarification is calcium hydroxide aqueous solution." Japan hanako materia medica ": granulation promoting is put on flesh, hemostasis.
Modern medicine proves: calcium hydroxide has astringing to arrest bleeding, antibacterial antisepsis.Can make mucosa wound surface form thin film, both can prevent external irritant, can breed and there is protective effect by anti-bacteria again, pathogen is had to stronger killing action.
(1) can lower the permeability of blood capillary, to inflammation, swelling has preventive and therapeutic effect.
(2) can increase dense ℃ of calcium ion in blood, make blood vessel densification, prevent that blood plasma from oozing out, promote blood coagulation, and direct contract skin blood vessel, anastalsis had.
(3) can reduce oozing out of mucosal surface secretions, have astriction.
(4) the comprehensive various acids of energy, absorb poison, and have itching-relieving action.
(5) have that dispersing swelling and dissipating binds, hemostasis are held back wet, anti-inflammatory analgetic, erosion wart is treated skin ulcer effect.
Nature and flavor with return through: pungent, warm; Poisonous.Return liver, spleen channel.
Function with cure mainly: dampness, parasite killing, hemostasis, analgesic therapy, erosion dislike meat.Control scabies, eczema, wound hemorrhage, the burning hot wound of soup, hemorrhoid, proctoptosis.Removing dampness sore: for burn due to hot liquid or fire.Hemostasis: for traumatic hemorrhage.
Erosion nevus: for melanotic nevus.Nature and flavor and usage: suitable amount used externally.Do not take orally.Be mainly used in scald, traumatic hemorrhage.
8. glycerol: also claiming glycerol, is a kind of colourless or micro-yellow transparent thick liquid, nontoxic, odorless, non-corrosiveness, have stronger hygroscopicity, can generate multiple esters with mineral acid and organic acid reaction, can form polyglycerol under certain condition.Be skin moisturizing wetting agent, can infiltrate skin horny layer and absorb moisture, moisture is locked in intercellular substance, and allocates the required moisture of skin in good time, the long period maintains skin optimum moisture content.Ichthyosis patient is due to sebaceous gland, the serious atrophy of sweat gland, secreted sebum, perspiration can not moisten and moistening skin effectively, and the clear squama of medicine desilting also has certain inhibitory action to the secretion of sebaceous gland, glycerol, by the dilution proportion the best of (1:20), is conducive to the moisturizing of skin.
9. propylene glycol: propylene glycol be unsaturated polyester (UP), epoxy resin, polyurethane resin important source material, the viscosity of propylene glycol and good hygroscopicity, and nontoxic, thereby in food, medicine and cosmetics industry, be widely used as hygroscopic agent, antifreeze, lubricant and solvent.In food industry, propylene glycol and fatty acid response generate methyl glycol fatty acid ester, mainly as food emulsifying agent; Propylene glycol is the fine solvent of flavoring agent and pigment.Propylene glycol is commonly used for solvent, softening agent and the excipient etc. of manufacturing all kinds of ointment, ointment in medical industry, because propylene glycol and all kinds of spice have better intersolubility, thereby is also used as the solvent of cosmetics and softening agent etc.Propylene glycol is also as Nicotiana tabacum L. humidizer, antifungus agent, and the aqueous solution of propylene glycol is effective antifreeze.
10. stearic acid: formal name used at school: octadecanoid acid.Containing the satisfied fatty acid of 18 carbon atoms.It is a kind of main component that forms animal and plant oils and fats.Can be used for the products such as pharmaceutical preparation, ointment, soap and suppository.
11.C16-18 alcohol: be that genus natural fatty alcohol is also a kind of emulsion stabilizer.For medicine ointment, fragrance is pure, can reduce essence consumption.It is the raw material of medical ointment.
12. glyceryl monostearates: glyceryl monostearate is to contain C16-C18 long-chain fatty acid and glycerol carries out esterification and makes.It is a kind of surfactant of nonionic.It existing hydrophilic have again lipophilic group because of, there is the several functions such as moistening, emulsifying, foaming.This product is milky ceraceous solid, dissolves in methanol, ethanol, chloroform, the solution such as acetone and ether.Emulsifying agent and the additive of food; In cosmetics and medical unguentum, be used as emulsifying agent, make mastic exquisiteness, lubricious.
13. emulsifying agent A-165: or claim tristerin/PEG-100 stearic acid ester, the business of Guangzhou Fei Rui Chemical Co., Ltd. sells.Be nonionic self emulsifying monoglyceride, emulsifying capacity is strong, is O/W emulsifying agent.Can be used alone or make co-emulsifier.No matter have necessarily for thickening property, be emulsion or thicker mastic, and it has splendid stability.Can emulsifying to polarity and nonpolar oils and fats, and the fine and smooth light of emulsifying mastic outward appearance out, auxiliary malleability are good, easily smear, give product very comfortable smear characteristic, effectively bring into play functional component.With the composite use of MONTANOV series emulsifying agent, can reach satisfied effect.
14.MAPK--50 emulsifying agent: chemical name: 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium salt, transparency liquid or white paste, the low stimulation of safety, similar natural phospholipid, character gentleness, is desirable cream frost emulsifying agent; Good emulsifying, solubilising and dispersive property; Lower surface tension, foam is abundant fine and smooth; Good moist performance; Salt tolerant, acid-proof alkaline excellence; Water solublity is good, can be used for cold batching; Good biological degradability, is specially adapted to prepare clean gel of foam facial milk cleanser and foam, various shampoo, bath gel, handwashing liquid, and gentle infant nursing product.
15. dimethicones: another name methyl-silicone oil, polysiloxanes, dimethicone, silicone oil, have physiology inertia, good chemical stability, electric edge and weatherability, sticky ℃ scope is wide, and freezing point is low, flash-point is high, and hydrophobic performance is good, and has very high shear resistance.Dimethicone, is not also decomposed by body fluid without toxigenicity human body, therefore in medical and health care system, be also widely used.Utilize its froth breaking effect, made oral gastrointestinal flatulence relieving tablet, and pulmonary edema froth breaking aerosol etc. is medicinal.In ointment, add silicone oil, can improve the penetrating power of medicine to skin, improve drug effect.Some plaster take silicone oil as base oil has good curative effect to scald, dermatitis, decubital ulcer etc., utilizes the blood coagulation resisting function of silicone oil, and available its processed storage blood device surface, extends blood sample period of storage etc.Also can be used as condom wet type lubricant, and its Killing Sperm not.On cosmetics, add silicone oil can improve moistening and protective effect etc. skin.
16. propyl p-hydroxybenzoate: also claim propylparaben, white crystalline powder, is soluble in alcohol and ether, almost insoluble in water, mainly as the sterilization antiseptic of food, cosmetics, medicine.
17. ethylparabens: also claim ethyl hydroxybenzoate, colourless tiny crystallization or crystalloid powder, almost odorless, slightly astringent taste, to light and thermally stable, no hygroscopicity, 1g this product is approximately dissolved in 1340mL, water, 1.4mL propylene glycol and the 100mL Oleum Arachidis hypogaeae semen of 25 ℃, mainly as food, cosmetics, medical sterilization antiseptic.
18. Sang Pu LGP antibacterial: liquid, chemical name: 1,3-dihydroxymethyl-5,5-dimethyl hydantoin, IPBC, butanediol.Broad spectrum antibiotic activity, can effectively suppress gram negative bacteria, positive bacteria, yeast and mycete, is mainly used in the sterilization antiseptic of cosmetics, medical cream frost, dew liquid, hair care category, sunscreen products, baby products, eye cosmetic, wet paper towel.
19. deionized waters: refer to and removed the pure water being after ionic species impurity.
Granulation promoting healing ointment function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting, drive away the poison that becomes silted up, improve skin pruritus and microcirculation disturbance, repair damaged skin cell tissue, promote skin tissue cell regeneration, improve the disease-resistant and immunocompetence of skin, supplement human body necessary (saccharide, protein, fat, vitamin, mineral) five large basic nutrition key elements.Be mainly used in treatment: empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, redly flood, chilblain, the dermatosis such as chap.
Specification: 15 grams 30 grams 50 Ke ∕ prop up, one, every box.
Using method
:external, is applied to affected part, general patient, and every day is early, middle and late respectively once, empyrosis, traumatic injury, eczema, chilblain patient, ointment is evenly applied to wound surface, thickness is in 1mm left and right, within every 2 hours, smear once, while changing dressings, with ointment, left drug on wound surface and liquefied substance are wiped away, and then smearing ointment as stated above, after wound surface incrustation will incrustation place surface and around smearing ointment, until incrustation Automatic-falling generates new skin, newborn skin surface and around to continue smearing ointment, wound surface exposes medication best results, until newborn skin surface color thin out or approach normal skin color after by every day early, in, respectively once smear evening, after recovering normal skin quality, skin can discontinue medication, more after, skin is beautiful, moist, flexible, non-pigment calmness, without cicatrix.
Advantage of the present invention is:
1, granulation promoting healing ointment is centered by life power element (Zn zinc, Fe ferrum, Ca calcium, Mn manganese, Gu copper, Mo Molybdenum, Ti titanium, Mg magnesium, Sr strontium, Ge germanium, Rb rubidium, Se selenium, etc. 20 multi mineral trace element) metal ion, form best moisture complex ion with 6～7 hydrones, various effective ingredient can be become with micro-magnetic moment, upper state, high infiltration, the moisture complex ion group of multi-functional short chain linear structure.Its hydrodynamic radius is 0.1nm, it is 0.1%～1% of human body cell, because associated water molecules degree is very little, be very easy to through skin surface cell film, will be with positive charge, d track, life power element and the various effective ingredient of micro-magnetic moment, directly bring in the organizational structure of Skin Cell and enzyme, participate in biochemical reaction.By the effect of the moisture complex ion of various trace element and enzyme, supplement rapidly relevant to life in organism mine trace elements such as () Zn zinc, Mn manganese, Gu copper, Fe ferrum, Mo Molybdenum, Co cobalt, Ti titanium, Mg magnesium, Ca calcium, Sr strontium, Ge germanium, Rb rubidium, K potassium, Na sodium, Si silicon, B boron, Se selenium, I iodine and various nutrient substance, repair damaged skin cell, promote skin cell metabolism, accelerate the synthetic of nucleic acid and collagen protein, reach and recover skin regeneration ability with this, allow skin recover elasticity and healthy object.Another characteristic that granulation promoting jade closes cream is to utilize the moisture complex ion group of life power element automatically to generate the characteristic of ecological oxygen (O) and hydroxyl radical free radical (OH), kill various antibacterials and the virus of growing on human body skin, decompose and get rid of various harmful substances, and then reaching the object of " prevent skin infection, promote skin regeneration, eliminate skin pruritus, recover skin health ".
2, granulation promoting jade closes cream obvious novelty in prescription and processing technology, and mastic exquisiteness, softness, stretchability are good, free from extraneous odour, and safe and reliable, therapeutic effect is satisfactory, is a kind of medical ointment of reasonable external curing dermatosis.
3, through to 100 empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, redly flood, chilblain, the dermatosis crowd such as chap use, total effective rate 96%.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.
The specific embodiment
Embodiment 1
Granulation promoting healing ointment, comprises that the raw material of following weight is made: 200 grams of Oleum sesami, 20 grams of life power elements, 10 grams of vitamin Es, 25 grams of trehaloses, 5 grams of allantoin, 5 grams, Cera Flava, 50 grams of glycerol, 1 gram of calcium hydroxide.
Embodiment 2
Granulation promoting healing ointment, comprises that the raw material of following weight is made: 200 grams of Oleum sesami, 20 grams of life power elements, 10 grams of vitamin Es, 25 grams of trehaloses, 5 grams of allantoin, 5 grams, Cera Flava, 50 grams of glycerol, 1 gram of calcium hydroxide, 10 grams of stearic acid, 15 grams of monoglycerides, 15 grams of C16-18 alcohol, 15 grams of emulsifying agent A-165,50 grams of propylene glycol, 10 grams of dimethicones, 35 grams of MAPK-50 emulsifying agents, 1 gram of propylparaben, 1.5 grams of Methyl p-hydroxybenzoates, 1.5 grams, essence, 2 grams of LGP antibacterial, 528 grams of deionized waters.Make 1000 grams of mastic.
Note: calcium hydroxide can be made aqueous solution.
Or calcium hydroxide can be in the time of 20 ℃, add the ratio preparation calcium hydroxide aqueous solution of 100 grams of deionized waters in 0.17 gram of calcium hydroxide, fully stir, dissolve, leave standstill, to get supernatant for subsequent use.
Embodiment 3
Granulation promoting healing ointment production technology:
A phase (oil phase): Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, propylene glycol, propylparaben.
B phase (water): deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying agent.
C phase: life power element, natural Vitamin E, LGP antibacterial, essence.
(1) A phase, B phase, the mutually various raw and auxiliary materials of C are weighed respectively in proportion successively,
(2) by A phase, B inserts respectively heating in water bath in oil, kettle after weighing mutually, by A, B is biphase all to be dissolved, and stirs, and A is put first to enter in vacuum emulsifying pot mutually, then B is slowly added mutually A mutually in, heating in water bath, stirring, homogenizing, emulsifying in vacuum emulsifying pot, emulsifying temperature is 85 degree, insulation emulsification times is 20 minutes.
Mastic temperature in pot is dropped to 65 while spending, then C is slowly added mutually to A, B stir in mutually, homogenizing, after stirring, can stop; Drop to 35 while spending until mastic temperature, close vacuum homogeneous emulsifying machine, leave standstill 24 hours, obtain granulation promoting healing ointment.
(3) inspection of semifinished product.(4) fill.(5) packing.(6) examination and test of products.(7) finished product warehouse-in.
Experimental example
Clinical experiment case:
Granulation promoting jade closes 65571 Army Hospitals of the routine clinical use of cream 100 visual report-Chinese People's Liberation Army
According to trustee's requirement, my institute has set up sensitive, exclusive, accurately method in clinical application, the given the test agent that trustee is provided carries out actual clinical check, from in January, 2012--in January, 2013, at me institute's dermatosis training and burn and scald training, granulation promoting jade is closed to cream for " empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, red flooding, chilblain, chap " etc. dermatosis crowd " amount to 100 routine experimenters, through the clinical observation of 30 days (course for the treatment of use amount), therapeutic effect is satisfied, now by as follows tested crowd's physical record effect report:
Be used for observing product standard specimen character standard specimen: it is medicinal plastic tube packing that granulation promoting jade closes cream, and every fills 30 grams of mastic, and good seal amounts to 600.The milky white exquisiteness of mastic, good fluidity, stretching are good, and transdermal characteristic is good, Water-In-Oil mastic, have light Semen Sesami fragrance, and after wiping, skin is comfortable, softness, silk cunning, nonirritant, safe and reliable.
Product prescription: granulation promoting jade closes cream standard specimen (embodiment 2 fills a prescription).
Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anti-inflammatory anti-itch, astringing to arrest bleeding, putrefaction-removing granulation-promoting.
Be mainly used in empyrosis, traumatic injury, mosquito bite, ultraviolet injury, computer radiate, skin allergy, eczema, redly flood, the treatment of chilblain, the disease such as chap.
Clinical case ordinary circumstance and standard formulation: the international diagnostic criteria of experiment AnMHO, experimental group voluntarily, in the situation of knowing the inside story, with the medical dermatosis experimenter of Xuan100Li Lai institute, minimum 18 years old of age, maximum 64 years old; Administration time unification was limited with 30 days, formulated treatment standard: 1. empyrosis patient, hinder that face inflammation disappears, blister stops oozing out for effectively (skin crust is stable), hinder flushingly swollenly disappear, newborn skin generates, be effective (cutting crust) without cicatrix after more; Otherwise be invalid.2. other patients, skin surface transference cure, redness disappear, pore recovers normally, skin smooth is effective, and symptom becomes the lighter into effective.Otherwise be invalid.
Therapeutic modality: 1 part of every example,, is used separately granulation promoting jade to close cream treatment dermatosis by 6 every part.
Conclusion: granulation promoting jade closes cream and applies that modern mastic manufacturing technology is refining to be formed, and standard specimen additional disclosure shows: granulation promoting jade closes cream and includes: life power element (mine trace element concentrated solution), vitamin E, trehalose, allantoin, calcium hydroxide, Oleum sesami, Cera Flava, glycerol etc. are raw material.Examining report demonstration, granulation promoting jade closes cream to rabbit skin nonirritant, and to guinea pig skin, without sensitization, to rat skin avirulence, physics and chemistry and microorganism part are qualified, and granulation promoting jade closes cream sample and uses and also have no adverse reaction through 100 routine experimenters.
Data shows: life power element (being mine trace element concentrated solution) includes the mine trace element that kind more than 27 is relevant to human life, wherein the metal ion such as zinc, manganese, copper, Tie, Molybdenum, cobalt, titanium, magnesium, strontium, germanium is in human body biochemical reaction, to play catalysis, the life power element with positive charge, d track, micro-magnetic moment of activation.
Through investigating: it is centered by life power element (being mine trace element concentrated solution) metal ion that granulation promoting jade closes cream, form best moisture complex ion with 6～7 hydrones, various effective ingredient can be become with micro-magnetic moment, upper state, high infiltration, the moisture complex ion group of multi-functional short chain linear structure.Its hydrodynamic radius is 0.1nm, it is 0.1%～1% of human body cell, because associated water molecules degree is very little, be very easy to through skin surface cell film, will be with positive charge, d track, life power element and the various effective ingredient of micro-magnetic moment, directly bring in the organizational structure of Skin Cell and enzyme, participate in biochemical reaction.By the effect of the moisture complex ion of various trace element and enzyme, supplement rapidly relevant to life in organism mine trace elements such as () Zn zinc, Mn manganese, Gu copper, Fe ferrum, Mo Molybdenum, Co cobalt, Ti titanium, Mg magnesium, Ca calcium, Sr strontium, Ge germanium, Rb rubidium, K potassium, Na sodium, Si silicon, B boron, Se selenium, I iodine and various nutrient substance, repair damaged skin cell, promote skin cell metabolism, accelerate the synthetic of nucleic acid and collagen protein, reach and recover skin regeneration ability with this, allow skin recover elasticity and healthy object.Another characteristic that granulation promoting jade closes cream is to utilize the moisture complex ion group of life power element automatically to generate the characteristic of ecological oxygen (O) and hydroxyl radical free radical (OH), kill various antibacterials and the virus of growing on human body skin, decompose and get rid of various harmful substances, and then reaching the object of " prevent skin infection, promote skin regeneration, eliminate skin pruritus, recover skin health ".
In sum, granulation promoting jade closes cream obvious novelty in prescription and processing technology, and mastic exquisiteness, softness, stretchability are good, free from extraneous odour, and safe and reliable, therapeutic effect is satisfactory, is a kind of medical ointment of reasonable external curing dermatosis.
Claims (5)
1. treat a granulation promoting healing ointment for skin class disease, it is characterized in that being made by the raw material of following weight: Oleum sesami 150-250 gram, 10-25 gram of life power element, vitamin E 5-15 gram, trehalose 10-30 gram, allantoin 1-5 gram, Cera Flava 2-10 gram, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram.
2. treat the granulation promoting healing ointment of skin class disease for one kind, it is characterized in that being made by the raw material of following weight: Oleum sesami 150-250 gram, life power element 10-25 gram, vitamin E 5-1.5 gram, trehalose 10-30 gram, allantoin 1-5 gram, Cera Flava 2-10 gram, glycerol 30-50 gram, calcium hydroxide 0.5-1.0 gram, stearic acid 10-20 gram, monoglyceride 10-20 gram, C16-18 alcohol 10-20 gram, emulsifying agent A-165 10-20 gram, propylene glycol 30-50 gram, dimethicone 5-15 gram, MAPK-50 emulsifying agent 30-50 gram, propylparaben 0.5-1.5 gram, Methyl p-hydroxybenzoate 1-2 gram, essence 1-2 gram, LGP antibacterial 1.0-2.0 gram, deionized water 450-700 gram.
3. according to granulation promoting healing ointment claimed in claim 1, it is characterized in that: 200 grams of Oleum sesami, 20 grams of life power elements, 10 grams of vitamin Es, 25 grams of trehaloses, 5 grams of allantoin, 5 grams, Cera Flava, 50 grams of glycerol, 1.0 grams of calcium hydroxide.
4. according to granulation promoting healing ointment claimed in claim 2, it is characterized in that: 200 grams of Oleum sesami, 20 grams of life power elements, 10 grams of vitamin Es, 25 grams of trehaloses, 5 grams of allantoin, 5 grams, Cera Flava, 50 grams of glycerol, 1.0 grams of calcium hydroxide; 10 grams of stearic acid, 15 grams of monoglycerides, 15 grams of C16-18 alcohol, 15 grams of emulsifying agent A-165,50 grams of propylene glycol, 10 grams of dimethicones, 35 grams of MAPK-50 emulsifying agents, 1 gram of propylparaben, 1.5 grams of Methyl p-hydroxybenzoates, 1.5 grams, essence, 2 grams of LGP antibacterial, 528 grams of deionized waters.
5. a preparation method for the granulation promoting healing ointment as described in claim 2 or 4, is characterized in that:
(1) raw material: A phase: Oleum sesami, stearic acid, monoglyceride, C16-18 alcohol, emulsifying agent A-165, Cera Flava, dimethicone, propylene glycol, propylparaben;
B phase: deionized water, calcium hydroxide, trehalose, allantoin, glycerol, Methyl p-hydroxybenzoate, MAPK-50 emulsifying agent;
C phase: life power element, vitamin E, LGP antibacterial, essence;
(2) step:
A phase, B phase, the mutually various raw and auxiliary materials of C are weighed respectively in proportion successively, by A phase, B inserts respectively heating in water bath in oil, kettle after weighing mutually, by A, B is biphase all to be dissolved, stir, A is put first to enter in vacuum emulsifying pot mutually, then B is slowly added mutually A mutually in, heating in water bath, stirring, homogenizing, emulsifying in vacuum emulsifying pot, emulsifying temperature is 85 degree, and insulation emulsification times is 20 minutes;
Mastic temperature in pot is dropped to 65 while spending, then C is slowly added mutually to A, B stir in mutually, homogenizing, after stirring, can stop; Drop to 35 while spending until mastic temperature, close vacuum homogeneous emulsifying machine, leave standstill 24 hours, obtain granulation promoting healing ointment.
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| CN105919839A (en) * | 2016-06-28 | 2016-09-07 | 郑州雷曼药业有限公司 | Skin-care cream for repairing chapped skin and preparation method thereof |
| WO2020012136A1 (en) | 2018-07-13 | 2020-01-16 | Gifrer Barbezat | Alkaline oleo-liniment |
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