CN104382843A

CN104382843A - Skin repair gel

Info

Publication number: CN104382843A
Application number: CN201410588110.4A
Authority: CN
Inventors: 程朝霞; 张春明; 李俊明; 吴春华
Original assignee: TIANJIN JIASHITANG SCIENCE AND TECHNOLOGY Co Ltd
Current assignee: TIANJIN JIASHITANG SCIENCE AND TECHNOLOGY Co Ltd
Priority date: 2014-10-28
Filing date: 2014-10-28
Publication date: 2015-03-04
Anticipated expiration: 2034-10-28
Also published as: CN104382843B

Abstract

The invention discloses skin repair gel. The skin repair gel is prepared from the following components in percentage by weight: 3-8 percent of mycose, 2-20 percent of simethicone, 1-3 percent of an emulsifier, 5-10 percent of a wetting agent and 65-78 percent of purified water. Experiments prove that the gel disclosed by the invention can be used for maintaining normal breathability of the skin, is beneficial for generating beneficial bacteria and high in moisturizing function, provides a good wet healing environment for wounds, quickens the healing of the wounds, causes no irritation to the skin, relieves symptoms such as xerosis, itching, swelling, fever and pain of the wound skin, and is low in cost and convenient to use.

Description

A kind of skin repair gel

Technical field

The present invention relates to a kind of biomaterial for medical purpose, be specifically related to a kind of skin repair gel.

Technical background

Everybody has a love of beauty, along with the raising of people's economic level, people are also willing to be intended to pursue on beautiful road spend more money, so there have been a series of beauty treatment means, such as, laser photorejuvenation, fruit acid change skin etc., but these expensive technological means, also likely bring side effect, the dry red and swollen heat pain of itching of skin may be made.

Acne affects face and health a kind of disease attractive in appearance, and bringing injury not only to the body & mind of people, is also the burden of patient's heart on the impact of self-image.

Human body skin wound surface disease has now become one of the highest disease of society sickness rate, be no matter postoperative wound surface or traumatic surface also or the wound surface caused by reason such as ulcer, erosion, burn and scald, easy infection, the problem such as slow that heals have become puzzlement doctor and the personage's that a likes to be beautiful difficult problem all.At present, the main method controlling wound infection is local debridement and medication, but local application may produce bacterial drug resistance.

Dimethicone is tasteless nontoxic, there is good chemical stability and physiological inertia, other component in product can be made to be easy to diffuse into thin film on skin, and without thickness sense, simultaneously as carrier, dimethicone can dissipate rapidly and make the thin film that in product, other components uniformly distribute.The hydrophobic film that dimethicone is formed can keep again the normal breathability of skin.But the cost of dimethicone is higher, and slight stimulation can be produced to sensitive skin when being used alone.

Trehalose is a kind of safe and reliable natural saccharide.Trehalose can keep the normal humidity of wound surface also can provide good condition for the growth of granulation tissue and wound surface epithelization.But moisture-retaining capacity is limited.

Summary of the invention

An object of the present invention is to overcome the deficiencies in the prior art, provide one can prebiotic probiotics, moisture-keeping function be strong, accelerates healing speed, with low cost, skin is not had to the skin repair gel of stimulation.

Technical scheme of the present invention is summarized as follows:

A kind of skin repair gel, is characterized in that being made up of the purified water of the dimethicone of 3%-8% trehalose, 2%-20%, the emulsifying agent of 1%-3%, the wetting agent of 5%-10% and 65%-78% by weight percentage.

The kinematic viscosity of dimethicone is preferably 5000-60000cst.

Emulsifying agent is preferably cetearyl alcohol, PEG-7 castor oil hydrogenated, glyceryl stearate, sorbitol sesquioleate, lauroyl glutamate ester and polyglycereol-3 at least one.

Wetting agent is preferably glycerol, propylene glycol and 1,3 butylene glycol at least one.

Experiment proves: gel of the present invention can keep the normal breathability of skin, prebiotic probiotics, moisture-keeping function is strong, for wound surface provides good Moist healing environment, accelerate healing speed, with low cost, stimulation is not had to skin, alleviate the dry symptoms such as red and swollen heat pain of itching of wound surface skin, easy to use.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further illustrated.

Detailed description of the invention

Embodiment 1

A kind of skin repair gel, by weight percentage by the trehalose of 3%, the kinematic viscosity of 20% be 5000cst dimethicone, 3% PEG-7 castor oil hydrogenated, the glycerol of 9% and the purified water of 65% make.

Embodiment 2

A kind of skin repair gel, by weight percentage by the trehalose of 4%, the kinematic viscosity of 18% be 10000cst dimethicone, the polyglycereol-3 of 2%, the 1,3 butylene glycol of 8% and 68% purified water make.

Embodiment 3

A kind of skin repair gel, by weight percentage by 5% trehalose, 15% kinematic viscosity be 15000cst dimethicone, 2% cetearyl alcohol, 8% glycerol and 70% purified water make.

Embodiment 4

A kind of skin repair gel, by weight percentage by 6% trehalose, 13% kinematic viscosity be 20000cst dimethicone, 2% lauroyl glutamate ester, the propylene glycol of 6% and the purified water of 73% make.

Embodiment 5

A kind of skin repair gel, by weight percentage by 7% trehalose, 10% kinematic viscosity be 25000cst dimethicone, 2% PEG-7 castor oil hydrogenated, the propylene glycol of 6% and the purified water of 75% make.

Embodiment 6

A kind of skin repair gel, by weight percentage by 8% trehalose, 8% kinematic viscosity be 30000cst dimethicone, 1% glyceryl stearate, the propylene glycol of 5% and the purified water of 78% make.

Embodiment 7

A kind of skin repair gel, by weight percentage by 8% trehalose, 5% kinematic viscosity be 40000cst dimethicone, 1% sorbitol sesquioleate, the glycerol of 10% and the purified water of 76% make.

Embodiment 8

A kind of skin repair gel, by weight percentage by 8% trehalose, 2% kinematic viscosity be 45000cst dimethicone, 2% lauroyl glutamate ester, the 1,3 butylene glycol of 10% and the purified water of 78% make.

Embodiment 9

A kind of skin repair gel, by weight percentage by 8% trehalose, 2% kinematic viscosity be 50000cst dimethicone, 1% lauroyl glutamate ester, the cetearyl alcohol of 1%, the glycerol of 10% and 78% purified water make.

Embodiment 10

A kind of skin repair gel, by weight percentage by 8% trehalose, 2% kinematic viscosity be 60000cst dimethicone, 2% glyceryl stearate, the glycerol of 5%, the propylene glycol of 5% and 78% purified water make.

Embodiment 11

The compound method of gel:

By the formula of one of embodiment 1-10, by trehalose and purified water mix homogeneously, be heated to 85 DEG C, add wetting agent again and emulsifying agent mix homogeneously obtains gelatinous liquid, dimethicone is joined in gelatinous liquid under homogenizing, mix homogeneously, is cooled to 40-50 DEG C, namely obtains skin repair gel.

Embodiment 12

Wound healing assay

Get 140 sd male rats (every only heavy 250g-270g), be divided into 14 groups at random, often organize 10, label respectively, in back spinal side, cut off hair, cut long 2cm with scalpel, the edge of a knife of degree of depth 0.2cm, use respectively the gel of trehalose, dimethicone, embodiment 1-10, silica-based wound repair material (Shanghai Guijian Biological Material Co., Ltd.) (positive control), do not use any medicine (blank).

Morning, noon and afternoon every day smear for three times, observe wound healing situation.

Wound healing situation is evaluated with Wound healing rate.

Wound healing rate=(original wound surface area-do not heal wound surface area)/original wound surface area.With imageJ software processes picture, calculate Wound healing rate.

Table 1 wound healing situation (often organizing computation of mean values) (%)

Embodiment 13

Zhao so-and-so, female, 12 years old, when travelling outdoors, accidentally abraded by leg skin, after clean illing skin, use the gel of embodiment 5, be applied in affected part, morning, noon and afternoon every day use three times.

Use after 15 minutes, pain disappears;

First day, illing skin starts healing;

3rd day, illing skin all healed, started incrustation;

7th day, illing skin decrustation, illing skin takes on a red color;

Tenth day, illing skin color recovered normal, does not form cicatrix.

Patient's private prosecution: gel of the present invention does not have stimulation to skin.

Embodiment 14

Lee, female, 35 years old, the face skin that fruit acid causes after changing skin cosmetic surgery failure was rubescent, pruritus, and pain uses the gel of embodiment 16, was applied in affected part after clean face.

Use after 1 hour, make use feeling cool; Comfortable; The skin that swells and ache is not bitterly; Pruritus alleviates;

In morning next day, pruritus stops;

3rd day, skin redness started to shoal;

5th day, skin redness obviously shoaled;

7th day, face recovered face impaired before state.

Embodiment 15

In the summer, man, 20 years old, facial acne was had a surplus for 4 years, and Face and cheek acne merges in flakes, and color is red, and there are pus born of the same parents tip.After clean skin of face, use the gel of embodiment 17, every day sooner or later respectively once

Use after 1 hour, make use feel salubrious;

7th day, facial acne area started to reduce, red and swollen disappearance;

28 day, acne disappeared substantially.

Claims

1. a skin repair gel, is characterized in that being made up of the purified water of the dimethicone of 3%-8% trehalose, 2%-20%, the emulsifying agent of 1%-3%, the wetting agent of 5%-10% and 65%-78% by weight percentage.

2. a kind of skin repair gel according to claim 1, is characterized in that the kinematic viscosity of described dimethicone is 5000-60000cst.

3. a kind of skin repair gel according to claim 1, is characterized in that described emulsifying agent is cetearyl alcohol, PEG-7 castor oil hydrogenated, glyceryl stearate, sorbitol sesquioleate, lauroyl glutamate ester and polyglycereol-3 at least one.

4. a kind of skin repair gel according to claim 1, is characterized in that described wetting agent is glycerol, propylene glycol and 1,3 butylene glycol at least one.