CN103340843B - Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus - Google Patents
Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus Download PDFInfo
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Abstract
The invention discloses a macromolecular compound latex scar paste used for controlling subjective discomforts such as local pruritus and fever caused by hypertrophic scar after wound healing of burn. The latex comprises the following components of hydroxypropyl guar gum powder, polymethyl methacrylate-chitin, methyl salicylate, heparin sodium, allantoin, menthol, camphor and borneol. Animal experiments and human body tests verify that the macromolecular compound latex (scar paste) is exact in itch-relieving effect, and can be used for controlling subjective discomforts such as local pruritus and fever caused by hypertrophic scar.
Description
Technical field
The present invention relates to a kind ofly for controlling the macromolecule composite emulsion note that burns the subjective uncomfortable disease such as local pruritus, heating that hypertrophic cicatrix causes after wound and wound surface healing, belong to medical technical field.
Background technology
Skin is the organ of human body maximum, is the important natural cover for defense of protection body.In life, some pruritus diseases of skin are often perplexing patient, have a strong impact on patient's quality of life.So-called pruritus is a kind of unhappiness sensation that causes the desire of scratching of skin or mucosa.The reason that causes skin pruritus is a lot, for example, for serious skin injury two degrees and three degrees burn and scald as dark in large area patient, form serious hypertrophic cicatrix and may cause violent pruritus after wound healing; Other some skin pruritus diseases also have oneself cause and onset of disease mechanism separately, as allergy, xerosis cutis, smegma hypofunction, neural spiritual reason etc.For skin pruritus disease, etiological treatment is very crucial, but the treatment of suiting the medicine to the illness is also very important for the quality of life of improving patient.
Guar gum is as a kind of polysaccharide polymer being made up of galactose and mannose, also referred to as galactomannan, be a member of galactomannan family, be mainly derived from the guar gum bean that India and Pakistan produce, in the conglomeraties such as food, medicine, papermaking, building, have application at present.Natural guar gum has good water solublity, this is mainly because contain a large amount of very easily water-soluble galactose units in its molecular side chain, these galactose side are water-soluble, make guar gum strand spread apart in aqueous solution, form a kind of material of the Hydrogels with certain viscosity in water.
Chitosan is similar to guar gum; for the product after chitin deacetylase base, derive from shell and the molluscan organ etc. of the Crustaceans such as shrimp, Eriocheir sinensis, insecticide, chitosan is a kind of nontoxic, good biocompatibility; biodegradable polymer, is widely used in medicine, food industry.Utilize chitosan and polymethyl methacrylate compound can be in a large number the chitosan by commercially available commercialization be in batch prepared into polymethyl acrylate-chitosan nano complex that we need, this complex can be with guar gum compound and by the pharmaceutical pack such as salicylic acid and menthol by wherein.
Salicylic acid, has another name called oxybenzoic acid, is a kind of white crystalline powder, is widely used in the industry such as cosmetics medicine, rubber.It for the preparation of the medicine such as aspirin, sodium salicylate, has relieving itching and eliminating swelling, the functions such as analgesic antiphlogistic as the raw material of medical industry; Heparin sodium, can alleviating pain, anticoagulant, inflammation-inhibiting reaction, promote revascularization, recovers local blood confession, and can affect the synthetic and degraded of collagen, makes the skin smooth after wound healing, alleviates cicatrix and cicatricial contracture; Allantoin, can horny layer softening albumen, as alleviating and treatment xeroderma, can make skin keep moisture content, moistens and soft.
Menthol, belongs to class cyclohexane extraction monoterpene derivative, colourless acicular crystal or granular.For the main component in Oleum menthae, exist with the state of ester to dissociate.Natural menthol is left-handed, has antibacterial and anti-inflammation functions, can be used for dermopathic external-use lotion, has the effect of refrigerant, antipruritic and antiinflammatory; Camphora, being coated with to put on the skin in skin can stimulate Cold receptor and have a refrigerant sense, can antipruritic pain relieving, there is slight local anesthesia effect; Borneolum Syntheticum, the crystallization obtaining in the resin that main component is Borneolum Syntheticum and volatile oil, also has the antipruritic effect of clearing away heat to alleviate pain.
Utilize at present the pharmaceutical products of guar gum and polymethyl acrylate-chitosan complexes to apply to wrap up wound site after wound more, protect from infection, there is the effect of anti-inflammatory analgetic simultaneously, and do not hinder the normal activity in joint.But utilization and improvement aspect the subjective uncomfortable disease such as local pruritus, heating causing at control hypertrophic cicatrix for it, have no relevant report.
And more existingly mostly be taking ointment, spray, gel, Antipruritic adhesive plaster as main for antipruritic externally applied product.Mainly there are following limitation in its itching-relieving action: action time is short, and the effect of relieving itching and eliminating swelling is undesirable, and have larger toxic and side effects.Therefore, exploitation is longer a kind of action time, effective and relative low price, application is convenient, and the external use anti pruritic product of good biocompatibility seems particularly important, in the hope of in the various etiological treatments for pruritus, alleviate violent pruritus symptom, improve patient's quality of life.
Summary of the invention
For above-mentioned situation, the object of this invention is to provide a kind of composite emulsion scar note for the subjective uncomfortable disease such as local pruritus, heating that after the healing of inhibition of sintering wound and wound surface, hypertrophic cicatrix causes, introduce the antipruritic medicine of suiting the medicine to the illness, utilize latex softness, and there is good plasticity and extensibility, also there is the feature of certain viscosity simultaneously, can cover for a long time parcel patient's pruritus place, reach the effect of relieving itch discomfort.
Technical scheme of the present invention is as follows:
A kind of composite emulsion scar note, it comprises following component:
Guar gum: described guar gum is that the guar gum content of boration is 40%wt～52%wt through the guar gum of the boration of borate crosslinked formation;
Polymethyl acrylate-chitosan: described polymethyl acrylate-chitosan is that average diameter is 200nm, form core by polymethyl acrylate, chitosan forms the nano-particle of shell, crosslinked by covalent bond or electrostatic interaction and guar gum, the content of polymethyl methacrylate-chitin nano-particle is 30%～42%wt;
Methyl salicylate: described methyl salicylate content is 6～18%wt;
Can also there be one or more (choice of carrying out following component according to various symptomatic treatments is added) in following component: adding to weight is %wt: heparin sodium, allantoin, menthol, Camphora, Borneolum Syntheticum.
In the time that they all add, their consumption is preferably: heparin sodium content is that 40～70IU/g, Content of Allantoin 1～2%wt, menthol content are that 0.5～1.5%wt, Camphora content are that 0.5～1.5%wt, content of bornyl alcohol are 1～2%wt.
Guar gum hydrogel of the present invention is the hydrogel through the boration of borate crosslinked formation.Wherein boron hydroxide ion complex
make by following balanced type:
Reaction, at 25 DEG C, is carried out under the condition of PH=11.Because make by above-mentioned balanced type with this understanding,
concentration arrive maximumly, reacting phase is to fully.?
in the mixture of/guar gum, boron ion first with guar gum mannose backbone on cis hydroxyl groups group crosslinked, form 1:1 complex, then in the same way with another one guar gum mannose backbone on cis hydroxyl groups group crosslinked, final one
form guar gum polymer in conjunction with two guar gum molecules, the further cross-linked polymeric of guar gum polymer, forms guar gum hydrogel, forms 2:1 complex.At 25 DEG C, while reaction under the condition of PH=11, also there is reaction comparatively gentle, the comparatively faster advantage of simultaneous reactions speed, two-step method mechanism as shown in Figure 1.
The nano-particle that polymethyl acrylate-chitosan nano complex of the present invention is composited by polymethyl acrylate and chitosan, as shown in Figure 2, its amino acid group and self be with positive electric charge to be cross-linked by covalent bond or electrostatic interaction and guar gum.Meanwhile, due to polymethyl acrylate-chitosan hydrophilic-hydrophobic structure, this nano-complex can drug coated molecule.
Tool of the present invention has the following advantages:
1, can be used for controlling the subjective uncomfortable disease such as local pruritus, heating that the rear hypertrophic cicatrix of burning wound and wound surface healing causes, action time is longer, effective, need not repeatedly change.
2, the present invention adopts guar gum composite polypropylene acid methyl ester-chitosan, and the latex softness of preparation, plasticity are strong, and have certain viscosity, can be used for wrapping up affected part, comfortable, do not hinder motion.
3, the safety of scar note glue is good, little to the toxic and side effects of human body.
Brief description of the drawings
Fig. 1 is the crosslinked mechanism of preparing boron ion/guar gum complex hydrogel of two-step method;
Fig. 2 is acrylic acid methyl ester .-chitosan nano composite structure figure;
Fig. 3 ICR Mice licking response number of times block diagram;
Fig. 4 is pruritus scoring block diagram.
Detailed description of the invention
By the following examples the present invention is specifically described; be necessary to be pointed out that at this present embodiment is only used to further illustrate the present invention; can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
Effective ingredient of the present invention is guar gum hydrogel, polymethyl acrylate-chitosan nano complex, methyl salicylate, heparin sodium, allantoin, menthol, Camphora and Borneolum Syntheticum.Wherein:
Embodiment mono-
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
20g chitosan, 10g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 30g of preparation is added in guar gum hydrogel 50g, add methyl salicylate 17.5g, heparin sodium 40IU, allantoin 1g, menthol 0.5g, Camphora 0.5g, Borneolum Syntheticum 0.5g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment bis-
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
30g chitosan, 15g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 8 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 42g of preparation is added in guar gum hydrogel 50g, add methyl salicylate 6g, heparin sodium 50IU, allantoin 1g, Borneolum Syntheticum 1g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment tri-
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
20g chitosan, 10g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 30g of preparation is added in guar gum hydrogel 52g, add methyl salicylate 14.5g, allantoin 2g, Borneolum Syntheticum 1.5g simultaneously, continue to stir 4 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment tetra-
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 42g of preparation is added in guar gum hydrogel 40g, add methyl salicylate 15.5g, heparin sodium 40IU, allantoin 1g, menthol 0.5g, Borneolum Syntheticum 1g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment five
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 8 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 45g of preparation is added in guar gum hydrogel 35g, add methyl salicylate 13.5g, allantoin 2g, menthol 1.5g, Camphora 1.5g, Borneolum Syntheticum 1.5g simultaneously, continue to stir 4 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment six
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 39g of preparation is added in guar gum hydrogel 45g, add methyl salicylate 12g, heparin sodium 40IU, allantoin 1g, menthol 1g, Camphora 1g, Borneolum Syntheticum 1g simultaneously, continue to stir 4 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment seven
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
20g chitosan, 10g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 30g of preparation is added in guar gum hydrogel 50g, add methyl salicylate 18g, heparin sodium 60IU, allantoin 1g, menthol 1g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment eight
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
20g chitosan, 10g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 8 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 30g of preparation is added in guar gum hydrogel 50g, add methyl salicylate 17g, heparin sodium 50IU, menthol 1g, Camphora 1g, Borneolum Syntheticum 1g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment nine
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 50g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 41 of preparation is added in guar gum hydrogel 49g, add methyl salicylate 8g, allantoin 1g, menthol 0.5g, Borneolum Syntheticum 0.5g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment ten
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 45g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 8 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 40g of preparation is added in guar gum hydrogel 45g, add methyl salicylate 7g, heparin sodium 70IU, allantoin 2g, menthol 2g, Camphora 2g, Borneolum Syntheticum 2g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 11
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 40g of preparation is added in guar gum hydrogel 52g, add methyl salicylate 7.5g, heparin sodium 40IU, Borneolum Syntheticum 0.5g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, and the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 12
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 42g of preparation is added in guar gum hydrogel 52g, add methyl salicylate 6g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 13
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 42g of preparation is added in guar gum hydrogel 52g, add methyl salicylate 6g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 14
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
20g chitosan, 10g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 30g of preparation is added in guar gum hydrogel 52g, add methyl salicylate 18g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 15
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 42g of preparation is added in guar gum hydrogel 40g, add methyl salicylate 18g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 16
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 39g of preparation is added in guar gum hydrogel 49g, add methyl salicylate 12g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Embodiment 17
Under 25 DEG C of conditions, get 1mmol/L boric acid 1L, add 1mmol/L NaOH, while utilizing PH meter to regulate PH=11, stop adding in the process adding, react after 10 minutes, add guar gum 55g, 25 DEG C are reacted and obtain guar gum hydrogel half an hour.
33g chitosan, 11g acrylic acid methyl ester. are mixed and added in distilled water 50ml, ultrasonic disruption instrument 750w effect 30min, ultrasonic dispersion 5 minutes (300w), 30 DEG C of lasting stirring reactions 9 hours, vacuum drying at 50 DEG C, obtains polymethyl acrylate-chitosan nano complex powder body.
Polymethyl acrylate-chitosan nano complex powder body 38g of preparation is added in guar gum hydrogel 45g, add methyl salicylate 17g simultaneously, continue to stir 3 hours, this mixed gel is put into 40 DEG C of incubators 3 days, the gel of getting after solidifying is scar note glue (being composite emulsion scar note).
Below zoopery and the human trial checking situation to antipruritic effect of the present invention:
Experiment 1:
The preparation of 1.1 Cavia porcellus pruritus models: before experiment, 48h is first by the cropping of right back Cavia porcellus instep, and depilatory loses hair or feathers, the about 1cm of area
2, experiment abraded depilation place skin with fine sandpaper the same day more gently, made it rubescent, but taking not hemorrhage as degree, smeared 0.05% histamine phosphate 30 μ L/ for each group in site of injury, and in 30min, there is licking the action of right back sufficient wound site in Cavia porcellus;
The 1.2 scar note glue that use embodiment mono-to prepare are made 3 × 1 × 0.3cm lamellar, wrap up right foot, and as experimental group, matched group is left intact.Record each group Cavia porcellus (5 every group) in 10min and lick the number of times (lick continuously and lick to occurring minibreak, lick licking 1 calculating) of licking right foot reaction; Result is as follows:
The Cavia porcellus of histamine induction is licked to the impact of foot reaction
As calculated: suppression ratio=49.5%(suppression ratio=(matched group-scar note glue group)/matched group × 100%)
Experiment 2:
2.1ICR mice (the title (being equivalent to BALB/c mouse) of a kind of mice, purchased from Third Military Medical University's Experimental Animal Center), male 10, the about 20g of body weight, is divided into matched group and scar note glue group at random, every group 5, the conventional preserved skin depilation in back, is prepared into 3 × 3 × 0.3cm lamellar by scar note glue (being prepared by embodiment bis-), the skin after the depilation of parcel mouse back, two groups are all given 4-aminopyridine lmgkg in depilation place subcutaneous injection, record and in mice 10min, lick body number of times.
The ICR Mice licking response number of times of 4-aminopyridine induction
As calculated: suppression ratio=58.60%(suppression ratio=(matched group-scar note glue group)/matched group × 100%)
2.2 statistic analysis result are as Fig. 3, and statistical analysis shows: p < 0.0001, prompting scar note glue group Mice licking response number of times is obviously few compared with matched group, the clear and definite antipruritic effect of scar note glue.
Experiment 3:
3.1 choose hypertrophic cicatrix pruritus patient 20 examples, inclusive criteria: 1) burn wound's area 10% left and right, and there is scar hyperplasia in half a year in wound healing, and pruritus is obvious; 2) 18～65 one full year of life of age, male or female; 3) get rid of following case: other serious diseases patients such as severe cardiac, brain, liver, kidney; Spirit, patient with nervous system disease; Tumor patient; Gestation, women breast-feeding their children; Compliance is poor, the person that is difficult to completed treatment; Serious immunodeficiency person; Drug abuse or drugs person.
Patient is divided at random experimental group and matched group by 3.2, every group of 10 people, measure every patient's cicatrix region area, scar note glue (being prepared by embodiment tri-) is prepared into area to experimental group and cicatrix area is similar, thickness is about 0.3cm size (be every square decimeter and use the about 10g of scar note glue).The rear hypertrophic cicatrix of dry combustion method wound and wound surface healing region is cleaned and wiped to warm water gently, and glue is naturally bonding, and used continuously 24 hours every day, changes every other day scar note glue one time.Matched group will not any processing.
3.3 evaluate by the following universal standard Relationship between maternal pruritus after using for 1,3,5,7 day, and calculate every patient's of four days average mark:
Pruritus standards of grading: 0 point: without pruritus.1 point: accidental pruritus.2 points: discontinuity pruritus, has symptom fluctuation.3 points: persistence pruritus, day and night unchanged.
3.4 results are as follows:
Patient's pruritus scoring (meansigma methods)
Referring to Fig. 4, statistic analysis result is shown: burn wound and wound surface healing after scar note glue is processed after, hypertrophic cicatrix accompanies violent pruritus patient's pruritus scoring significantly to decline, and patient's pruritus symptom alleviates.
Claims (5)
1. a composite emulsion scar is pasted, and it comprises following component:
Guar gum: described guar gum is that the guar gum content of boration is 40%wt～52%wt through the guar gum of the boration of borate crosslinked formation;
Polymethyl acrylate-chitosan: described polymethyl acrylate-chitosan is to form core by polymethyl acrylate, chitosan forms the nano-particle of shell, nano-particle average diameter is 200nm, crosslinked by covalent bond or electrostatic interaction and guar gum, the content of polymethyl acrylate-chitosan nano particle is 30%～42%wt;
Methyl salicylate: described methyl salicylate content is 6～18%wt.
2. composite emulsion scar according to claim 1 is pasted, and it is characterized in that: can also comprise one or more in following component: heparin sodium, allantoin, menthol, Camphora, Borneolum Syntheticum.
3. a composite emulsion scar is pasted, and it is composed of the following components:
Guar gum: described guar gum is that the guar gum content of boration is 40%wt～52%wt through the guar gum of the boration of borate crosslinked formation;
Polymethyl acrylate-chitosan: described polymethyl acrylate-chitosan is to form core by polymethyl acrylate, chitosan forms the nano-particle of shell, nano-particle average diameter is 200nm, crosslinked by covalent bond or electrostatic interaction and guar gum, the content of polymethyl acrylate-chitosan nano particle is 30%～42%wt;
Methyl salicylate: described methyl salicylate content is 6～18%wt;
Heparin sodium content is 40～70IU/g;
Content of Allantoin 1～2%wt;
Menthol content is 0.5～1.5%wt;
Camphora content is 0.5～1.5%wt;
Content of bornyl alcohol is 1～2%wt.
4. paste according to the composite emulsion scar described in claim 1,2 or 3, it is characterized in that: the boron hydroxide ion complex of the guar gum of described boration
make by following balanced type:
It reacts at 25 DEG C, under the condition of pH=11, carries out.
5. the composite emulsion scar described in claim 1,2,3 or 4 is attached to the application in the medicine of local pruritus that preparation treatment hypertrophic cicatrix causes or heating.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103550254B (en) * | 2013-11-04 | 2015-03-11 | 中国人民解放军第三军医大学第一附属医院 | Breathable itching-relieving antisepsis scar treating paster and preparation method thereof |
| JP5897164B2 (en) * | 2014-07-22 | 2016-03-30 | 小林製薬株式会社 | Composition for external use |
| US20170224613A1 (en) * | 2014-09-30 | 2017-08-10 | Chongqing Mj Medical Devices Co., Ltd. | Hydrogel compositions, methods for preparing the same and uses thereof |
| GB2535562B8 (en) * | 2014-09-30 | 2017-07-19 | Chongqing Mj Medical Devices Co Ltd | Hydrogel compositions and their use in the treatment of symptoms induced by hypertrophic scars |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628634A (en) * | 2004-08-31 | 2005-06-22 | 贵州太和制药有限公司 | Hydrophilic biological sticking gel pasting agent and preparation technique thereof |
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| US20140005269A1 (en) * | 2010-11-26 | 2014-01-02 | University Of The Witwatersrand, Johannesburg | Polymeric matrix of polymer-lipid nanoparticles as a pharmaceutical dosage form |
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|---|---|---|---|---|
| CN1628634A (en) * | 2004-08-31 | 2005-06-22 | 贵州太和制药有限公司 | Hydrophilic biological sticking gel pasting agent and preparation technique thereof |
Non-Patent Citations (2)
| Title |
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| 瓜尔豆胶的生产及其应用研究进展;顾振东 等;《广西轻工业》;20100731(第140期);11-13、34页 * |
| 顾振东 等.瓜尔豆胶的生产及其应用研究进展.《广西轻工业》.2010,(第140期),11-13、34页. * |
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