CN1628634A - Hydrophilic biological sticking gel pasting agent and preparation technique thereof - Google Patents
Hydrophilic biological sticking gel pasting agent and preparation technique thereof Download PDFInfo
- Publication number
- CN1628634A CN1628634A CN 200410040593 CN200410040593A CN1628634A CN 1628634 A CN1628634 A CN 1628634A CN 200410040593 CN200410040593 CN 200410040593 CN 200410040593 A CN200410040593 A CN 200410040593A CN 1628634 A CN1628634 A CN 1628634A
- Authority
- CN
- China
- Prior art keywords
- gel
- polyacrylic acid
- patch
- sodium
- linking agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 27
- 150000004676 glycans Chemical class 0.000 claims abstract description 25
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 25
- 239000005017 polysaccharide Substances 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 17
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 229920001184 polypeptide Polymers 0.000 claims abstract description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 5
- 239000000499 gel Substances 0.000 claims description 139
- 229920002125 Sokalan® Polymers 0.000 claims description 51
- 239000004584 polyacrylic acid Substances 0.000 claims description 51
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- 239000003814 drug Substances 0.000 claims description 42
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 41
- 239000011734 sodium Substances 0.000 claims description 41
- 229910052708 sodium Inorganic materials 0.000 claims description 41
- 239000003431 cross linking reagent Substances 0.000 claims description 38
- -1 is that 10-90 Substances 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000758 substrate Substances 0.000 claims description 29
- 239000000227 bioadhesive Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 23
- 108010010803 Gelatin Proteins 0.000 claims description 20
- 239000008273 gelatin Substances 0.000 claims description 20
- 229920000159 gelatin Polymers 0.000 claims description 20
- 235000019322 gelatine Nutrition 0.000 claims description 20
- 235000011852 gelatine desserts Nutrition 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 235000010603 pastilles Nutrition 0.000 claims description 15
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 14
- 230000008961 swelling Effects 0.000 claims description 14
- 229920006037 cross link polymer Polymers 0.000 claims description 13
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 12
- 239000000654 additive Substances 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 230000000149 penetrating effect Effects 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000010238 camphora Substances 0.000 claims description 10
- 229940025250 camphora Drugs 0.000 claims description 10
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical group COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 9
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 9
- 239000004743 Polypropylene Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 238000004132 cross linking Methods 0.000 claims description 9
- 238000005516 engineering process Methods 0.000 claims description 9
- 229920001155 polypropylene Polymers 0.000 claims description 9
- 229960001259 diclofenac Drugs 0.000 claims description 8
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 8
- 229960000991 ketoprofen Drugs 0.000 claims description 8
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 7
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 claims description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 7
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000005642 Oleic acid Substances 0.000 claims description 7
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 7
- 235000010489 acacia gum Nutrition 0.000 claims description 7
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 7
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 7
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 229920002907 Guar gum Polymers 0.000 claims description 6
- 241001597008 Nomeidae Species 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 235000010417 guar gum Nutrition 0.000 claims description 6
- 239000000665 guar gum Substances 0.000 claims description 6
- 229960002154 guar gum Drugs 0.000 claims description 6
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 5
- 229920001817 Agar Polymers 0.000 claims description 5
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 5
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 5
- 108010035532 Collagen Proteins 0.000 claims description 5
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 5
- 229960005233 cineole Drugs 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 5
- 229960001047 methyl salicylate Drugs 0.000 claims description 5
- 239000004302 potassium sorbate Substances 0.000 claims description 5
- 235000010241 potassium sorbate Nutrition 0.000 claims description 5
- 229940069338 potassium sorbate Drugs 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 241000717739 Boswellia sacra Species 0.000 claims description 4
- 239000004863 Frankincense Substances 0.000 claims description 4
- 241001057584 Myrrha Species 0.000 claims description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- 238000007796 conventional method Methods 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 239000000049 pigment Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims description 3
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 claims description 3
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims description 3
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 claims description 3
- 241000416162 Astragalus gummifer Species 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229920000742 Cotton Polymers 0.000 claims description 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 229920001615 Tragacanth Polymers 0.000 claims description 3
- 229940023476 agar Drugs 0.000 claims description 3
- 239000004411 aluminium Substances 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 239000005030 aluminium foil Substances 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229960000212 aminophenazone Drugs 0.000 claims description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- 235000010338 boric acid Nutrition 0.000 claims description 3
- 125000005619 boric acid group Chemical group 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000010624 camphor oil Substances 0.000 claims description 3
- 229960000411 camphor oil Drugs 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 235000013877 carbamide Nutrition 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 229940045110 chitosan Drugs 0.000 claims description 3
- 229960001193 diclofenac sodium Drugs 0.000 claims description 3
- 229940120889 dipyrone Drugs 0.000 claims description 3
- 239000003684 drug solvent Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 claims description 3
- 229960001395 fenbufen Drugs 0.000 claims description 3
- 229960002428 fentanyl Drugs 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 3
- 229960001680 ibuprofen Drugs 0.000 claims description 3
- 229960000905 indomethacin Drugs 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 claims description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 229960002969 oleic acid Drugs 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 229940059574 pentaerithrityl Drugs 0.000 claims description 3
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 3
- 229960002702 piroxicam Drugs 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920000193 polymethacrylate Polymers 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000009286 sanguis draxonis Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 3
- 229940032094 squalane Drugs 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 235000010487 tragacanth Nutrition 0.000 claims description 3
- 239000000196 tragacanth Substances 0.000 claims description 3
- 229940116362 tragacanth Drugs 0.000 claims description 3
- 229960003107 tramadol hydrochloride Drugs 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 2
- 238000001723 curing Methods 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims description 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 229920000642 polymer Polymers 0.000 abstract description 5
- 239000012620 biological material Substances 0.000 abstract 1
- 238000010792 warming Methods 0.000 description 19
- 239000007788 liquid Substances 0.000 description 15
- 206010042674 Swelling Diseases 0.000 description 13
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 239000012530 fluid Substances 0.000 description 9
- 229920002521 macromolecule Polymers 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical class Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- 239000000084 colloidal system Substances 0.000 description 8
- 229920001971 elastomer Polymers 0.000 description 7
- 239000012467 final product Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 239000003292 glue Substances 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical group NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- HDERJYVLTPVNRI-UHFFFAOYSA-N ethene;ethenyl acetate Chemical group C=C.CC(=O)OC=C HDERJYVLTPVNRI-UHFFFAOYSA-N 0.000 description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 239000010642 eucalyptus oil Substances 0.000 description 2
- 229940044949 eucalyptus oil Drugs 0.000 description 2
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 229940089161 ginsenoside Drugs 0.000 description 2
- 229930182494 ginsenoside Natural products 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- 239000000347 magnesium hydroxide Substances 0.000 description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241001489978 Eupolyphaga Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- BHTJEPVNHUUIPV-UHFFFAOYSA-N pentanedial;hydrate Chemical compound O.O=CCCCC=O BHTJEPVNHUUIPV-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Form | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel | ????5-45 |
Macromolecule (H) polyacrylic acid sodium gel | ????5-45 |
Polysaccharide gel | ????1-30 |
Peptide-based gel | ????5-50 |
First cross-linking agent | ????0.05-5 |
The end cross-linking agent | ????0.05-5 |
Pharmaceutical compositions | ????1-20 |
Penetrating agent | ????1-10 |
Solvent | ????1-10 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=3 * 10 5) | ????5 |
Macromolecule (H) polyacrylic acid sodium gel (M=3 * 10 9) | ????45 |
The guar gum gel | ????20.5 |
The gelatin glycerogel | ????16 |
Six hydration aluminum chlorides | ????0.3 |
Benzoyl peroxide | ????0.2 |
Ketoprofen | ????3 |
Oleum menthae | ????3 |
Glycerol | ????2 |
Nipagin ester propylene glycol liquid | ????1 |
Purified water | ????4 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=6 * 10 5) | ????45 |
Macromolecule (H) polyacrylic acid sodium gel (M=1 * 10 10) | ????5 |
The Radix astragali glue | ????9.5 |
The gelatin glycerogel | ????5 |
Aluminium-magnesium silicate | ????0.2 |
Epoxychloropropane | ????0.3 |
The Chinese medicine fluid extract | ????20 |
Oleic acid | ????4 |
Propylene glycol | ????4 |
Ethyl hydroxybenzoate | ????1 |
Purified water | ????4 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=2 * 10 5) | ????20 |
Macromolecule (H) polyacrylic acid sodium gel (M=5 * 10 8) | ????12 |
The xanthan glue | ????1 |
The osseocolla glycerogel | ????36 |
Ferric chloride (FeCl36H2O) | ????0.5 |
Acetaldehyde | ????5 |
The Chinese medicine fluid extract | ????8 |
Azone | ????2 |
Propylene glycol | ????6 |
Propylparaben | ????0.5 |
Purified water | ????8 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=7 * 10 5) | ????20 |
Macromolecule (H) polyacrylic acid sodium gel (M=2 * 10 9) | ????40 |
Sodium alginate gel | ????4.5 |
The gelatin glycerogel | ????16 |
Aluminum trichloride (anhydrous) | ????0.5 |
Sodium borate | ????1.6 |
Methyl salicylate | ????5 |
Oleum Camphora | ????3 |
Glycerol | ????2 |
Cyanine liquid | ????2 |
Purified water | ????5.4 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=8 * 10 6) | ????26 |
Macromolecule (H) polyacrylic acid sodium gel (M=2 * 10 10) | ????10 |
Chitosan gel rubber | ????30 |
The gelatin glycerogel | ????8 |
Anhydrous calcium chloride | ????4.5 |
Salicylic aldehyde | ????2.0 |
Diclofenac ethylenediamine salt | ????3.5 |
Borneolum Syntheticum | ????1 |
Dimethyl sulfoxide | ????2 |
Marennin liquid | ????2 |
Purified water | ????5.4 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=2 * 10 7) | ????30 |
Macromolecule (H) polyacrylic acid sodium gel (M=5 * 10 8) | ????10 |
The agar glue | ????25 |
The gelatin glycerogel | ????5 |
Magnesium hydroxide | ????0.1 |
Epoxychloropropane | ????5 |
The Chinese medicine fluid extract | ????15 |
Azone | ????2 |
Ethanol | ????1.5 |
Potassium sorbate | ????2.9 |
Purified water | ????3.5 |
Component | Components by weight percent |
Low molecule (S) polyacrylic acid sodium gel (M=3 * 10 5) | ????30 |
Macromolecule (H) polyacrylic acid sodium gel (M=3 * 10 9) | ????43 |
The arabic gum gel | ????2 |
The gelatin glycerogel | ????8 |
Six hydration aluminum chlorides | ????0.4 |
Glutaraldehyde | ????0.6 |
The ginsenoside | ????1 |
Eucalyptus oil | ????3 |
Azone | ????2 |
Cyanine liquid | ????2 |
Purified water | ????5 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100405930A CN1329022C (en) | 2004-08-31 | 2004-08-31 | Hydrophilic biological sticking gel pasting agent and preparation technique thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100405930A CN1329022C (en) | 2004-08-31 | 2004-08-31 | Hydrophilic biological sticking gel pasting agent and preparation technique thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1628634A true CN1628634A (en) | 2005-06-22 |
CN1329022C CN1329022C (en) | 2007-08-01 |
Family
ID=34845840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100405930A Expired - Lifetime CN1329022C (en) | 2004-08-31 | 2004-08-31 | Hydrophilic biological sticking gel pasting agent and preparation technique thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1329022C (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101780059A (en) * | 2010-03-12 | 2010-07-21 | 北京化工大学 | Transdermal preparation containing ligustrazine phosphate and preparation method thereof |
CN101879147A (en) * | 2010-06-21 | 2010-11-10 | 中国人民解放军军事医学科学院微生物流行病研究所 | Lornoxicam hydrogel patch and preparation method thereof |
CN101907617A (en) * | 2010-07-13 | 2010-12-08 | 深圳市药品检验所 | Quick measuring method of aminopyrine mixed in medicine and health-care foods |
CN101947322A (en) * | 2010-09-03 | 2011-01-19 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN101467984B (en) * | 2007-12-25 | 2012-05-23 | 上海医药工业研究院 | Tramadol gel for nose as well as preparation method and application thereof |
CN101502490B (en) * | 2009-02-26 | 2013-07-31 | 沈阳药科大学 | Ketoprofen bioadhesive gel microsphere and preparation method thereof |
CN103340843A (en) * | 2013-07-11 | 2013-10-09 | 中国人民解放军第三军医大学第一附属医院 | Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus |
CN103642052A (en) * | 2013-11-22 | 2014-03-19 | 北京迪百斯特科技发展有限公司 | Waterborne epoxy colorful floor paint and colored waterborne epoxy resin gel particle |
CN106074459A (en) * | 2016-07-11 | 2016-11-09 | 雷春生 | A kind of lasting water-retaining type hydrogel plaster supports the preparation method of layer material |
CN106309489A (en) * | 2016-09-28 | 2017-01-11 | 贵州特力达纳米碳素科技有限公司 | Medicinal patch for diminishing skin inflammation, and preparation method thereof |
CN107331868A (en) * | 2017-07-04 | 2017-11-07 | 佛山市中技烯米新材料有限公司 | A kind of coating fluid, its application method and battery pole piece |
CN107855080A (en) * | 2017-10-30 | 2018-03-30 | 中国科学院过程工程研究所 | Polymer gel particle, its preparation method, include its composite gel particle and purposes |
CN108498345A (en) * | 2018-04-23 | 2018-09-07 | 珠海国佳新材股份有限公司 | A kind of gel adhesive and preparation method thereof |
CN109971417A (en) * | 2017-12-28 | 2019-07-05 | 公安部物证鉴定中心 | A kind of gel-type footprint extracts film and its application |
CN113563611A (en) * | 2021-07-16 | 2021-10-29 | 浙江大学 | Biocompatible hydrogel dry powder and preparation method and application thereof |
CN114216942A (en) * | 2021-11-23 | 2022-03-22 | 广东省科学院化工研究所 | Method for depositing Prussian blue on flexible gold three-electrode |
CN114369192A (en) * | 2021-12-31 | 2022-04-19 | 南京紫鸿生物科技有限公司 | High-bioadhesion sodium polyacrylate gel, and preparation and application thereof |
CN115813816A (en) * | 2022-09-16 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
US11872320B2 (en) | 2021-02-25 | 2024-01-16 | Hisamitsu Pharmaceutical Co., Inc. | Method for treating osteoarthritis |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3845250B1 (en) * | 2018-08-30 | 2022-07-06 | FUJIFILM Corporation | Biocompatible material |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1149976C (en) * | 1999-03-19 | 2004-05-19 | 王英驰 | Adhesive polymer substrate and its application |
DE10141652B4 (en) * | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system based on polyacrylate pressure-sensitive adhesives without functional groups and its use |
EP1513889B1 (en) * | 2002-06-19 | 2008-04-09 | Showa Denko K.K. | Hydrous gel and production process and use of the hydrous gel |
CN1197575C (en) * | 2003-06-06 | 2005-04-20 | 中国人民解放军第二军医大学 | Cetirizing hydrochloride cataplasm preparation |
-
2004
- 2004-08-31 CN CNB2004100405930A patent/CN1329022C/en not_active Expired - Lifetime
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101467984B (en) * | 2007-12-25 | 2012-05-23 | 上海医药工业研究院 | Tramadol gel for nose as well as preparation method and application thereof |
CN101502490B (en) * | 2009-02-26 | 2013-07-31 | 沈阳药科大学 | Ketoprofen bioadhesive gel microsphere and preparation method thereof |
CN101780059A (en) * | 2010-03-12 | 2010-07-21 | 北京化工大学 | Transdermal preparation containing ligustrazine phosphate and preparation method thereof |
CN101879147B (en) * | 2010-06-21 | 2013-04-10 | 中国人民解放军军事医学科学院微生物流行病研究所 | Lornoxicam hydrogel patch and preparation method thereof |
CN101879147A (en) * | 2010-06-21 | 2010-11-10 | 中国人民解放军军事医学科学院微生物流行病研究所 | Lornoxicam hydrogel patch and preparation method thereof |
CN101907617A (en) * | 2010-07-13 | 2010-12-08 | 深圳市药品检验所 | Quick measuring method of aminopyrine mixed in medicine and health-care foods |
CN101947322A (en) * | 2010-09-03 | 2011-01-19 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN101947322B (en) * | 2010-09-03 | 2012-07-04 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN103340843A (en) * | 2013-07-11 | 2013-10-09 | 中国人民解放军第三军医大学第一附属医院 | Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus |
CN103340843B (en) * | 2013-07-11 | 2014-11-05 | 中国人民解放军第三军医大学第一附属医院 | Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus |
CN103642052A (en) * | 2013-11-22 | 2014-03-19 | 北京迪百斯特科技发展有限公司 | Waterborne epoxy colorful floor paint and colored waterborne epoxy resin gel particle |
CN103642052B (en) * | 2013-11-22 | 2015-09-23 | 北京迪百斯特科技发展有限公司 | The colorful floor paint of water-base epoxy and color aqueous epoxy resin gel particle |
CN106074459A (en) * | 2016-07-11 | 2016-11-09 | 雷春生 | A kind of lasting water-retaining type hydrogel plaster supports the preparation method of layer material |
CN106309489A (en) * | 2016-09-28 | 2017-01-11 | 贵州特力达纳米碳素科技有限公司 | Medicinal patch for diminishing skin inflammation, and preparation method thereof |
CN107331868A (en) * | 2017-07-04 | 2017-11-07 | 佛山市中技烯米新材料有限公司 | A kind of coating fluid, its application method and battery pole piece |
CN107855080B (en) * | 2017-10-30 | 2020-09-08 | 中国科学院过程工程研究所 | Polymer gel particle, preparation method thereof, composite gel particle containing polymer gel particle and application |
CN107855080A (en) * | 2017-10-30 | 2018-03-30 | 中国科学院过程工程研究所 | Polymer gel particle, its preparation method, include its composite gel particle and purposes |
CN109971417A (en) * | 2017-12-28 | 2019-07-05 | 公安部物证鉴定中心 | A kind of gel-type footprint extracts film and its application |
CN109971417B (en) * | 2017-12-28 | 2020-07-28 | 公安部物证鉴定中心 | Gel type footprint extraction film and application thereof |
CN108498345A (en) * | 2018-04-23 | 2018-09-07 | 珠海国佳新材股份有限公司 | A kind of gel adhesive and preparation method thereof |
CN108498345B (en) * | 2018-04-23 | 2019-03-05 | 珠海国佳新材股份有限公司 | A kind of gel adhesive and preparation method thereof |
US11872320B2 (en) | 2021-02-25 | 2024-01-16 | Hisamitsu Pharmaceutical Co., Inc. | Method for treating osteoarthritis |
CN113563611A (en) * | 2021-07-16 | 2021-10-29 | 浙江大学 | Biocompatible hydrogel dry powder and preparation method and application thereof |
CN114216942B (en) * | 2021-11-23 | 2023-11-21 | 广东省科学院化工研究所 | Method for depositing Prussian blue on flexible gold three-electrode |
CN114216942A (en) * | 2021-11-23 | 2022-03-22 | 广东省科学院化工研究所 | Method for depositing Prussian blue on flexible gold three-electrode |
CN114369192A (en) * | 2021-12-31 | 2022-04-19 | 南京紫鸿生物科技有限公司 | High-bioadhesion sodium polyacrylate gel, and preparation and application thereof |
CN115813816A (en) * | 2022-09-16 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
CN115813816B (en) * | 2022-09-16 | 2024-05-28 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN1329022C (en) | 2007-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1329022C (en) | Hydrophilic biological sticking gel pasting agent and preparation technique thereof | |
Nayak et al. | Sterculia gum-based hydrogels for drug delivery applications | |
CN1174746C (en) | Medicine release control type percutaneous absorber | |
Bera et al. | Carboxymethyl fenugreek galactomannan-gellan gum-calcium silicate composite beads for glimepiride delivery | |
KR101680148B1 (en) | Glucan compositions | |
Asati et al. | Bioadhesive or mucoadhesive drug delivery system: a potential alternative to conventional therapy | |
CN1354654A (en) | Transdermal therapeutic system with neutralized pressure sensitiivty acrylic adhesive patch | |
CN1816325A (en) | Hydrophilic adhesives for delivery of herbal medicines | |
CN1697656A (en) | Phentanyl-containing adhesive patch for application to oral-cavity mucosa | |
TW201328699A (en) | Pharmaceutical composition useful for adhesion prevention or hemostasis | |
CN1647803A (en) | Chinese medicine composition plaster for external anti-inflammation and analgetics | |
Mao et al. | Wet-adhesive materials of oral and maxillofacial region: from design to application | |
Xu et al. | Etamsylate loaded oxidized Konjac glucomannan-ε-polylysine injectable hydrogels for rapid hemostasis and wound healing | |
EP1174124B1 (en) | preparations for the percutanous administration of hydrophilic agents | |
CN1663999A (en) | Chitosan water-retaining gel adhesive substrate materials and method for preparing same | |
JP5398062B2 (en) | Hydrogel external preparation | |
CN105163725A (en) | Stabilization of essential oils within a hydrocolloid adhesive | |
CN1250662C (en) | Hydrophilc multi-component mixture pressure-sensitive adhesive and application thereof | |
CN1261101C (en) | Chitosan glycyrrhizic acid nano particle and its preparing method | |
CN110090198A (en) | A kind of slow-release canker sore gel and preparation method thereof with bioadhesive | |
JPH066533B2 (en) | Base for hydrogel patches | |
JP7523473B2 (en) | Biocompatible material and method for producing biocompatible material | |
CN1070051C (en) | Substrate for medical paste | |
CN1579560A (en) | Coblended contact glue of poly N-ethenyl pyrrolidone and polyvinyl alcohol and its use | |
Suksaeree | Mechanical properties of herbal patches from chitosan-based polymer blends for medical applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Effective date of registration: 20080422 Pledge (preservation): Pledge |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20091029 Pledge (preservation): Pledge registration |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Effective date of registration: 20091029 Pledge (preservation): Pledge |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20111116 Granted publication date: 20070801 Pledgee: Qingzhen City Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2009520000634 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Hydrophilic biological sticking gel pasting agent and preparation technique thereof Effective date of registration: 20111215 Granted publication date: 20070801 Pledgee: Qingzhen City Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2011990000491 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20121120 Granted publication date: 20070801 Pledgee: Qingzhen City Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2011990000491 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Hydrophilic biological sticking gel pasting agent and preparation technique thereof Effective date of registration: 20151214 Granted publication date: 20070801 Pledgee: Xifeng County Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2015520000009 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20161221 Granted publication date: 20070801 Pledgee: Xifeng County Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2015520000009 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Hydrophilic biological sticking gel pasting agent and preparation technique thereof Effective date of registration: 20170105 Granted publication date: 20070801 Pledgee: Xifeng County Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2017520000001 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20171219 Granted publication date: 20070801 Pledgee: Xifeng County Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2017520000001 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Hydrophilic biological sticking gel pasting agent and preparation technique thereof Effective date of registration: 20171222 Granted publication date: 20070801 Pledgee: Xifeng County Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2017520000015 |
|
PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20191025 Registration number: 2017520000015 Pledgee after: Guizhou Xifeng Rural Commercial Bank Co.,Ltd. Pledgee before: Xifeng County Rural Credit Cooperatives |
|
PM01 | Change of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191030 Granted publication date: 20070801 Pledgee: Guizhou Xifeng Rural Commercial Bank Co.,Ltd. Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2017520000015 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Hydrophilic biological sticking gel pasting agent and preparation technique thereof Effective date of registration: 20191105 Granted publication date: 20070801 Pledgee: Guizhou Xifeng Rural Commercial Bank Co.,Ltd. Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: Y2019520000012 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221103 Granted publication date: 20070801 Pledgee: Guizhou Xifeng Rural Commercial Bank Co.,Ltd. Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: Y2019520000012 |
|
CX01 | Expiry of patent term |
Granted publication date: 20070801 |