CN115813816B - Mild gel mask and application thereof - Google Patents
Mild gel mask and application thereof Download PDFInfo
- Publication number
- CN115813816B CN115813816B CN202211130779.XA CN202211130779A CN115813816B CN 115813816 B CN115813816 B CN 115813816B CN 202211130779 A CN202211130779 A CN 202211130779A CN 115813816 B CN115813816 B CN 115813816B
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- China
- Prior art keywords
- aqueous solution
- natural polysaccharide
- ionic crosslinking
- mask
- polysaccharide
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Links
- 239000007864 aqueous solution Substances 0.000 claims abstract description 120
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 116
- 239000005017 polysaccharide Substances 0.000 claims abstract description 116
- 150000004676 glycans Chemical class 0.000 claims abstract description 115
- 239000004480 active ingredient Substances 0.000 claims abstract description 50
- 238000004132 cross linking Methods 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 46
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 44
- 239000008367 deionised water Substances 0.000 claims description 26
- 229910021641 deionized water Inorganic materials 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 239000011248 coating agent Substances 0.000 claims description 12
- 238000000576 coating method Methods 0.000 claims description 12
- 238000005507 spraying Methods 0.000 claims description 11
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 9
- 102000008186 Collagen Human genes 0.000 claims description 9
- 108010035532 Collagen Proteins 0.000 claims description 9
- 239000004227 calcium gluconate Substances 0.000 claims description 9
- 229960004494 calcium gluconate Drugs 0.000 claims description 9
- 235000013927 calcium gluconate Nutrition 0.000 claims description 9
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical group [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 9
- 229920001436 collagen Polymers 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 8
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 8
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 230000003020 moisturizing effect Effects 0.000 claims description 7
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 5
- 229940072056 alginate Drugs 0.000 claims description 5
- 235000010443 alginic acid Nutrition 0.000 claims description 5
- 229920000615 alginic acid Polymers 0.000 claims description 5
- 239000000419 plant extract Substances 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 241000208340 Araliaceae Species 0.000 claims description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 229910052744 lithium Inorganic materials 0.000 claims description 3
- IHRKJQSLKLYWBQ-QKDODKLFSA-N (2s)-2-[[(2s)-1-[(2s)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O IHRKJQSLKLYWBQ-QKDODKLFSA-N 0.000 claims description 2
- XLELDISCQSKJES-IPPMYLEBSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(tetradecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O XLELDISCQSKJES-IPPMYLEBSA-N 0.000 claims description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 2
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920002498 Beta-glucan Polymers 0.000 claims description 2
- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229920002581 Glucomannan Polymers 0.000 claims description 2
- 229920002752 Konjac Polymers 0.000 claims description 2
- 229920000057 Mannan Polymers 0.000 claims description 2
- 235000016787 Piper methysticum Nutrition 0.000 claims description 2
- 240000005546 Piper methysticum Species 0.000 claims description 2
- 241001506047 Tremella Species 0.000 claims description 2
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims description 2
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 229940046240 glucomannan Drugs 0.000 claims description 2
- 235000010485 konjac Nutrition 0.000 claims description 2
- 229940078015 myristoyl pentapeptide-4 Drugs 0.000 claims description 2
- 229940093441 palmitoyl oligopeptide Drugs 0.000 claims description 2
- 229940094946 palmitoyl tetrapeptide-7 Drugs 0.000 claims description 2
- 239000000737 potassium alginate Substances 0.000 claims description 2
- 235000010408 potassium alginate Nutrition 0.000 claims description 2
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 241001523681 Dendrobium Species 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- 241000222336 Ganoderma Species 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 70
- 230000000052 comparative effect Effects 0.000 description 53
- 239000000243 solution Substances 0.000 description 23
- 239000000017 hydrogel Substances 0.000 description 16
- 238000004090 dissolution Methods 0.000 description 13
- 238000012360 testing method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 239000002994 raw material Substances 0.000 description 6
- 239000013543 active substance Substances 0.000 description 5
- 229920000554 ionomer Polymers 0.000 description 5
- 230000007794 irritation Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 239000004971 Cross linker Substances 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- -1 lipid compounds Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940089468 hydroxyethylpiperazine ethane sulfonic acid Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- JQMFQLVAJGZSQS-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)NC1=CC2=C(NC(O2)=O)C=C1 JQMFQLVAJGZSQS-UHFFFAOYSA-N 0.000 description 1
- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- QRVYVKGHSWMAJI-IYEMJOQQSA-L strontium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Sr+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O QRVYVKGHSWMAJI-IYEMJOQQSA-L 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a mild gel mask which comprises a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, wherein the natural polysaccharide aqueous solution comprises natural polysaccharide, an active ingredient and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, a permeation enhancer and water. The moderate-temperature gel mask disclosed by the invention is safe and reliable when being prepared on the basis of natural polysaccharide and an ionic crosslinking agent, and compared with a traditional non-woven fabric mask, the gel mask has better skin-friendly property and fitting property, has excellent water-retaining property, and solves the defect that the traditional mask cannot lock essence substances.
Description
Technical Field
The invention relates to a mild gel mask, a preparation method and application thereof, relates to A61K, and in particular relates to the field of cosmetic disposables.
Background
The gel mask is a mask using gel as a matrix, contains moisture and nutrient components, has good skin adhesion to the face, and overcomes the problems of high requirements on the face shape, strong rough texture and weak nutrient component bearing capacity of the traditional mask, and the gel mask has good skin feel and good tightness with skin, and is more and more concerned by people.
Chinese patent No. 202011336101.8 discloses a placenta cotyledon hydrogel mask and a preparation method thereof, placenta cotyledon of healthy animals is separated and fused with polyvinyl alcohol hydrogel solution to prepare copolymerized hydrogel, and the prepared mask has multiple beauty and skin care effects of nourishing skin, moisturizing, delaying skin aging and the like, but has higher cost and is not suitable for mass production. The Chinese patent CN202111679165.2 discloses a hydrogel mask taking vinasse melanoidin and Yang Shuya total flavone as main raw materials and a preparation method thereof, natural, green and harmless biopolymer matrix raw materials with good biocompatibility and excellent skin affinity are adopted to ensure that the mask matrix is free of sensitization, the prepared mask has the characteristics of good adhesion, good moisturizing and whitening effects, good peeling integrity and the like, but stabilizer EDTA is required to be introduced, and excessive EDTA addition can cause side effects, cause certain irritation to skin and cause problems of some skin.
Disclosure of Invention
In order to improve the efficacy expression of the gel mask and reduce the irritation of the permeation enhancer, the first aspect of the invention provides a mild gel mask, which is prepared from a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, wherein the natural polysaccharide aqueous solution comprises natural polysaccharide, an active ingredient and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, the permeation enhancer and water.
As a preferred embodiment, the mild gel mask is prepared by the following method:
(1) Adding the natural polysaccharide and the active ingredient into deionized water simultaneously or in batches, and stirring until the natural polysaccharide and the active ingredient are completely dissolved to obtain a natural polysaccharide aqueous solution (the simultaneous addition means that the natural polysaccharide and the active ingredient are added into the deionized water simultaneously and stirred for dissolution; the batch addition means that the natural polysaccharide is added into the deionized water firstly and stirred for dissolution, and then the active ingredient is added and stirred for dissolution);
(2) Adding the ionic crosslinking agent and the permeation enhancer into deionized water simultaneously or in batches, and stirring until the ionic crosslinking agent and the permeation enhancer are completely dissolved to obtain an ionic crosslinking aqueous solution (the simultaneous adding means that the ionic crosslinking agent and the permeation enhancer are added into the deionized water simultaneously and stirred for dissolution; the batch adding means that the ionic crosslinking agent is added into the deionized water firstly and stirred for dissolution, and then the permeation enhancer is added and stirred for dissolution);
(3) Firstly, coating a natural polysaccharide aqueous solution on the surface of skin, then spraying an ionic crosslinking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask.
As a preferred embodiment, the natural polysaccharide is selected from one or more of sodium alginate, potassium alginate, and lithium alginate.
As a preferred embodiment, the ionic crosslinking agent is selected from one or more of calcium gluconate, strontium gluconate, calcium chloride, lithium chloride, magnesium chloride, strontium chloride, and calcium sulfate.
As a preferred embodiment, the natural polysaccharide is sodium alginate and the ionic cross-linking agent is calcium gluconate.
As a preferred embodiment, the mass ratio of the natural polysaccharide to water is (1-6): 100, the mass ratio of the ionic cross-linking agent to water is (0.5-3.5): 100..
As a preferred embodiment, the active ingredient is present in the aqueous solution of natural polysaccharide in a mass concentration of 0.001-5% and the permeation enhancer is present in the aqueous solution of ionic crosslinking in a mass concentration of 0.5-10%.
The applicant finds that the active ingredients and the permeation enhancer of the mask are added respectively, and the active ingredients in the mask can be absorbed by mixing when the mask is used, and the skin irritation caused by the permeation enhancer in the mask is reduced, so that the mask can reduce the damage to the skin and is more suitable for sensitive skin. The reason may be because: the penetration enhancer is added to interact with the skin surface cuticle lipid to change the arrangement structure, so that the active ingredients can smoothly penetrate through each layer of the skin and be delivered to the target site of action, and the penetration enhancer is released at a proper concentration, so that the penetration enhancer has proper slow release rate and slow release quantity. However, the applicant finds that the permeation enhancer can also dissolve lipid compounds on the skin surface to cause cell shedding and has certain irritation to sensitive skin with barrier injury, so that the active ingredients and the permeation enhancer are respectively added into the natural polysaccharide aqueous solution and the ionic crosslinking aqueous solution, the permeation enhancer is prevented from directly contacting the skin, the contact time of the permeation enhancer and the skin is shortened, the natural polysaccharide aqueous solution is coated on the skin surface firstly when the permeation enhancer is used, and then the ionic crosslinking aqueous solution containing the permeation enhancer is sprayed. In addition, because the active ingredients are easy to be inactivated due to the influence of external conditions, the separate addition of the active ingredient permeation promoters is also helpful for guaranteeing the activity of the active substances and improving the stability.
As a preferred embodiment, the mass ratio of the natural polysaccharide to water in the natural polysaccharide aqueous solution is (2-6): 100, wherein the mass ratio of the ionic crosslinking agent to water in the ionic crosslinking aqueous solution is (1-2): 100.
As a preferred embodiment, the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution is 1: (0.2-2).
As a preferred embodiment, the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution is 1: (0.5-1).
As a preferred embodiment, the active ingredient is selected from one or more of a polypeptide-based component, a collagen-based component, a plant extract-based component, and a polysaccharide-based component.
As a preferred embodiment, the polypeptide component is selected from the group consisting of one or more of acetyl hexapeptide-8, palmitoyl tripeptide-1, myristoyl pentapeptide-4, palmitoyl tetrapeptide-7.
As a preferred embodiment, the polypeptide component is present in the aqueous natural polysaccharide solution at a concentration of 0.001-0.02% by mass.
As a preferred embodiment, the collagen-like component is selected from one or more of soluble collagen, hydrolyzed collagen, and combinations thereof.
As a preferred embodiment, the collagen-based component is present in the aqueous natural polysaccharide solution at a concentration of 0.5 to 5% by mass.
As a preferred embodiment, the plant extract-based component is selected from one or more of ginseng extract, kava extract, ganoderma lucidum extract, rose extract.
As a preferred embodiment, the mass concentration of the plant extract-based component in the aqueous natural polysaccharide solution is 0.1-5%.
As a preferred embodiment, the polysaccharide component is selected from one or more of rhamnose, mannan, beta-glucan, dendrobe, ginseng polysaccharide, oat polysaccharide, tremella polysaccharide, konjac glucomannan, chitosan, galactose, agarose.
As a preferred embodiment, the polysaccharide component is present in the aqueous solution of natural polysaccharide in a mass concentration of 0.1 to 2%.
As a preferred embodiment, the permeation enhancer is selected from one or more of ethanol, carbitol, azone, hydroxyethylpiperazine ethane sulfonic acid.
As a preferred embodiment, the mass concentration of the ethanol in the ionic crosslinking aqueous solution is 1-10%.
As a preferred embodiment, the mass concentration of the carbitol in the ionic crosslinking aqueous solution is 1-10%.
As a preferred embodiment, the azone is present in the aqueous ionomer solution at a mass concentration of 1-2%.
As a preferred embodiment, the mass concentration of the hydroxyethyl piperazine ethane sulfonic acid in the ionic crosslinking aqueous solution is 0.5-2%.
The second aspect of the invention provides an application of a mild gel mask, which is applied to a mask product with the effects of resisting aging, whitening, removing acnes, relieving and preserving moisture.
Compared with the prior art, the invention has the following beneficial effects:
(1) The moderate-temperature gel mask disclosed by the invention is safe and reliable when being prepared on the basis of natural polysaccharide and an ionic crosslinking agent, and compared with a traditional non-woven fabric mask, the gel mask has better skin-friendly property and fitting property, has excellent water-retaining property, and solves the defect that the traditional mask cannot lock essence substances.
(2) The moderate gel mask disclosed by the invention has the advantages that the active substances are added into the natural polysaccharide aqueous solution, the permeation enhancer is added into the ionic crosslinking aqueous solution, the ionic crosslinking aqueous solution is sprayed on the surface of the skin to form a film after the natural polysaccharide aqueous solution is coated on the surface of the skin, so that the permeation enhancer is prevented from directly contacting the skin, the contact time of the permeation enhancer and the skin is shortened, the natural polysaccharide aqueous solution is coated on the surface of the skin when the moderate gel mask is used, and the ionic crosslinking aqueous solution containing the permeation enhancer is sprayed after the natural polysaccharide aqueous solution is coated on the surface of the skin.
(3) For a common non-woven fabric mask or a traditional gel mask, the mask cannot be completely matched with the facial forms of different consumers, the method adopts a mode of spraying before forming, the natural polysaccharide aqueous solution is coated on corresponding positions according to requirements, then the ionic crosslinking aqueous solution is sprayed on the natural polysaccharide aqueous solution, a rapid crosslinking effect is generated under the action of ions, and finally the gel mask is formed, so that the formed mask has high fit with the skin, the facial forms of different consumers are highly matched, and particularly, seamless fit can be realized on the two sides of a nose wing, the chin, the eyes and other parts, thereby better transmitting moisture, functional components and the like to the skin. The mask is flexible and convenient to use, has controllable spraying range and shape, and can meet various requirements.
(4) The gel matrix natural polysaccharide aqueous solution and the ionic crosslinking aqueous solution adopt 1: (0.2-2), the obtained liquid mixture can be rapidly crosslinked on the surface of skin to form a film, and the formed gel mask has large bearing capacity and strong toughness, and can realize the carrying of various active ingredients.
(5) The gel mask provided by the invention has proper active ingredient carrying capacity, and after gel is formed into a film, the carried active ingredient has proper slow release time and higher slow release amount, the active substance is added into a natural polysaccharide aqueous solution, and the penetration enhancer is added into an ion crosslinking agent aqueous solution, so that the damage of some penetration enhancers to skin barriers is avoided to the greatest extent. On the one hand, the direct contact time of the permeation enhancer with the skin is reduced, and on the other hand, the natural polysaccharide aqueous solution has a direct and effective protective effect on the skin before the permeation enhancer contacts the skin.
(6) The gel mask has good moisturizing effect, can not suck back skin moisture after being applied for a long time like the traditional cloth-pasting mask, can be used as an instant mask with short application time or a sleep mask with long application time, can determine specific application time according to the actual requirement of a user, has flexible use, and can meet different requirements of the user.
Detailed Description
Example 1
The mild gel mask is prepared from the following raw materials in parts by weight: aqueous solution of natural polysaccharide: the natural polysaccharide is sodium alginate 2 parts, the active ingredient is rhamnose 1 part, and deionized water 100 parts; ionic crosslinking aqueous solution: the ionic crosslinking agent is 1 part of calcium gluconate, the penetration enhancer is 1.5 parts of azone and 100 parts of deionized water.
The mild gel mask is prepared by the following method:
(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring for 2h for dissolution at 800rmp, adding active ingredient, and stirring for 20min at 500rmp to obtain natural polysaccharide water solution;
(2) Preparing an ionomer aqueous solution: adding an ionic crosslinking agent into deionized water, stirring for 2 hours at 800rmp for dissolution, adding a permeation enhancer, and stirring for 20 minutes at 500rmp to obtain an ionic crosslinking aqueous solution;
(3) According to the volume ratio of 1:1, firstly coating a natural polysaccharide aqueous solution on the surface of skin, then spraying an ionic crosslinking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask. And (5) after the skin surface is applied for 30min, taking off the whole tablet.
Example 2
The specific preparation method of the mild gel mask is the same as that of example 1, except that the following components are used in parts by weight: aqueous solution of natural polysaccharide: the natural polysaccharide is 1 part of lithium alginate, the active ingredient is 1 part of rhamnose and 100 parts of deionized water; ionic crosslinking aqueous solution: the ionic crosslinking agent is 1 part of calcium chloride, the penetration enhancer is 1.5 parts of azone and 100 parts of deionized water.
Example 3
The specific preparation method of the mild gel mask is the same as that of example 1, except that the following components are used in parts by weight: aqueous solution of natural polysaccharide: the natural polysaccharide is 5 parts of sodium alginate, the active ingredient is 1 part of rhamnose and 100 parts of deionized water; ionic crosslinking aqueous solution: 3 parts of calcium gluconate as an ionic crosslinking agent, 1.5 parts of azone as a permeation promoter and 100 parts of deionized water.
Example 4
The mild gel mask preparation raw materials comprise natural polysaccharide aqueous solution and ionic crosslinking aqueous solution, and the parts by weight are as follows: aqueous solution of natural polysaccharide: the natural polysaccharide is 3 parts of sodium alginate, the active ingredient is 1 part of rhamnose and 100 parts of deionized water; ionic crosslinking aqueous solution: the ionic crosslinking agent is 2 parts of calcium gluconate, the penetration enhancer is 1.5 parts of azone and 100 parts of deionized water.
The mild gel mask is prepared by the following method:
(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring for 2h to dissolve at 700rmp, adding active ingredient, and stirring for 20min at 500rmp to obtain natural polysaccharide water solution;
(2) Preparing an ionomer aqueous solution: adding an ionic crosslinking agent into deionized water, stirring for 2 hours at 700rmp for dissolution, adding a permeation enhancer, and stirring for 20 minutes at 500rmp to obtain an ionic crosslinking aqueous solution;
(3) According to the volume ratio of 1: and 0.5, coating the natural polysaccharide aqueous solution on the surface of skin, and then spraying the ionic crosslinking aqueous solution on the surface of the coating formed by the natural polysaccharide aqueous solution to form a film to obtain the gel mask. And (5) after the skin surface is applied for 30min, taking off the whole tablet.
Example 5
A mild gel mask was substantially the same as in example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:0.1.
Example 6
A mild gel mask was substantially the same as in example 4, except that: the dosage of the ionic crosslinking agent calcium gluconate in the ionic crosslinking aqueous solution is 0.5 part.
Example 7
A mild gel mask was substantially the same as in example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:1.
Example 8
A mild gel mask was substantially the same as in example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:2.
Comparative example 1
A mild gel mask was substantially the same as in example 4, except that: the dosage of the natural polysaccharide sodium alginate in the natural polysaccharide aqueous solution is 7 parts.
Comparative example 2
A mild gel mask was substantially the same as in example 3, except that: the weight portions are as follows: the dosage of the ionic crosslinking agent calcium gluconate in the ionic crosslinking aqueous solution is 4 parts.
Comparative example 3
A mild gel mask was substantially the same as in example 2, except that: the amount of the ionic crosslinking agent calcium chloride in the ionic crosslinking aqueous solution was 0.5 part.
Comparative example 4
The gel mask is prepared from the following raw materials in parts by weight: aqueous solution of natural polysaccharide: the natural polysaccharide is 2 parts of sodium alginate, the active ingredient is 1 part of rhamnose, the penetration enhancer is 1.5 parts of azone, and 100 parts of deionized water; ionic crosslinking aqueous solution: the ionic crosslinking agent is 1 part of calcium gluconate and 100 parts of deionized water.
The mild gel mask is prepared by the following method:
(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring for 2h for dissolution at 800rmp, adding active ingredient and permeation enhancer, and stirring for 20min at 500rmp to obtain natural polysaccharide water solution loaded with active ingredient and permeation enhancer;
(2) Preparing an ionomer aqueous solution: adding an ionic crosslinking agent into deionized water, stirring for 2 hours at 800rmp for dissolution, and stirring for 20 minutes at 500rmp to obtain an ionic crosslinking aqueous solution;
(3) According to the volume ratio of 1:1, firstly coating a natural polysaccharide water solution loaded with an active ingredient and a permeation enhancer on the surface of skin, then spraying an ionic crosslinking water solution on the surface of the coating formed by the natural polysaccharide water solution, and forming a film to obtain the gel mask. And (5) after the skin surface is applied for 30min, taking off the whole tablet.
Comparative example 5
The mild gel mask is prepared from the following raw materials in the same way as in example 1, wherein the mild gel mask is prepared by the following method:
(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring for 2h for dissolution at 800rmp, adding active ingredient, and stirring for 20min at 500rmp to obtain natural polysaccharide water solution;
(2) Preparing an ionomer aqueous solution: adding an ionic crosslinking agent into deionized water, stirring for 2 hours at 800rmp for dissolution, adding a permeation enhancer, and stirring for 20 minutes at 500rmp to obtain an ionic crosslinking aqueous solution;
(3) Mixing natural polysaccharide water solution with ionic crosslinking water solution according to the ratio of 1: and (3) mixing the components according to the volume ratio of 1, and then injecting the mixture into a mold for shaping to obtain the gel mask. And (5) after the skin surface is applied for 30min, taking off the whole tablet.
Performance testing
In comparative example 3, after the aqueous solution of natural polysaccharide was applied to the skin surface and then sprayed with the aqueous solution of the ionic crosslinking agent, the formed film could not be completely torn off for a long time, probably because the ionic crosslinking reaction occurred less enough to form a complete film structure in the case where both the concentration of natural polysaccharide in the aqueous solution of natural polysaccharide and the concentration of the ionic crosslinking agent in the aqueous solution of the ionic crosslinking agent were low, and therefore, the performance test was not conducted for the formulation of comparative example 3 later.
1. And (3) testing the performance of the mask:
the base films prepared in examples 1 to 8, comparative examples 1 to 2, and comparative examples 4 to 5 were subjected to performance test using the following test methods.
1. Moisture retention performance: with reference to the test method of QB/T4256-2011, the skin moisture tester of capacitance method was used to test examples 1-8 and comparative examples 1-2,4-5, and 20 volunteers between 20-45 years of age were selected for each group. Skin moisture testing was performed prior to application of the mask. The hydrogel mask was then applied to the cheek in the correct manner and after 30 minutes the moisture of the skin was measured in the same areas on the left and right sides (3 areas were taken per volunteer and averaged). The average of the measured values is reported in table 1.
2. Physical cooling performance: trial experiments were performed on examples 1-8 and comparative examples 1-2,4-5 for examples and comparative examples, with each group selecting 10 volunteers between 20-45 years of age. The hydrogel mask was uniformly applied on the left cheek half, and the physical cooling performance of the hydrogel mask after 30min of application was measured (3 areas were taken for each volunteer and averaged) with the left and right cheeks as a control during wet application. The average of the measured values is reported in table 1.
3. The paste performance: trial experiments were performed on examples 1-8 and comparative examples 1-2,4-5 for examples and comparative examples, each group selecting 20 volunteers between 20-45 years old. The mask was applied for 30min, the volunteers remained normal sitting and simple activities during the mask application, the highest positions of the mask at the beginning and the end of the application were recorded, the difference between the two was the falling distance (3 times of test for each volunteer, average value was taken), and the test results are shown in table 1.
4. Glue forming time: hydrogel masks were prepared by the methods provided in examples and comparative examples, respectively, and skin test was performed after the preparation was completed, and the gel setting time of the hydrogels was observed (3 times per volunteer, average value was taken), and the measured results are reported in table 2.
5. Mechanical properties: vaseline is uniformly coated on the surface of the prepared hydrogel mask to avoid a large amount of dehydration, then a universal mechanical tester is used for testing the tensile strength of the hydrogel, the hydrogel is compressed at a speed of 1mm/min, the compressive strength of the hydrogel is tested, 10 samples are tested in each example comparative example, the average value is taken, and the average value of the measured values is recorded in Table 2.
TABLE 1
TABLE 2
As can be seen from tables 1 and 2, the gel mask prepared by the scheme of the invention has excellent moisturizing performance, moisturizing performance and physical cooling performance, and in addition, the mask has short gel forming time, good application performance and good mechanical performance.
Wherein the concentration of alginate in the aqueous solution of natural polysaccharide used in example 2 is lower, the lower concentration of alginate results in slower gel speed, so that the falling distance is larger and the gel forming time is longer. In example 5, the amount of the ionic crosslinking agent solution was reduced, so that the gel was not completely formed, and thus, a partial drop occurred. Example 6 reduced the gel speed after reducing the concentration of ionic crosslinker, and reduced the gel integrity, resulting in an increased drop distance.
However, the gel forming time in comparative example 1 was prolonged as compared with example 4, probably because the concentration of the natural polysaccharide in comparative example 1 was too high, and the too high concentration resulted in an increase in the viscosity of the natural polysaccharide aqueous solution, which was detrimental to the permeation of the ionic crosslinking agent, thereby making the gel time longer. The gel forming time in comparative example 2 was also prolonged compared to example 4, probably due to the too high concentration of the ionic crosslinker in comparative example 2, which resulted in rapid formation of a dense crosslinked network on the surface, affecting the penetration of the ionic crosslinker and thus extending the gel time. The skin of comparative example 5 has the lowest moisture content after use, which may be caused by two reasons, on one hand, since comparative example 5 is directly molded and then applied to the face, the overall adhesion is poor and the overall moisturizing effect on the skin is poor; on the other hand, the directly formed mask is formed by uniformly stirring the natural polysaccharide aqueous solution and the ionic crosslinking agent aqueous solution, so that a complete and compact gel crosslinking network can be formed, moisture can be more firmly locked in gel, the release effect of the moisture is poor, and the improvement of the moisture content of skin is less.
2. Efficacy test:
1. Active ingredient slow release: pouring the natural polysaccharide aqueous solutions loaded with rhamnose prepared in examples 1-8 and comparative examples 1,2 and 4 (the mass of the solutions used in each example is equal to that of the solution used in the comparative example) into a mould to uniformly spread the natural polysaccharide aqueous solutions, spraying the ionic crosslinking agent aqueous solution prepared in the step (2) on the surface of the natural polysaccharide aqueous solution according to the formula proportion of the example or comparative example, and taking out the natural polysaccharide aqueous solution from the mould after molding to obtain the hydrogel mask with basically the same shape; and (3) pouring the natural polysaccharide aqueous solution and the ionic crosslinking agent aqueous solution prepared in the comparative example 5 into a mold according to a proportion, uniformly stirring, waiting for molding, and taking out after molding to obtain the hydrogel mask with basically the same shape. The obtained hydrogel mask was immersed in 200mL of PBS buffer solution, respectively, and placed in a thermostatic waterbath shaker at 37 ℃. 2mL of liquid was aspirated at fixed time intervals, and 2mL of fresh PBS buffer was added to ensure a constant total volume. The active ingredient release profile was measured by HPLC (3 samples per sample, averaged). The results obtained are recorded in table 3.
2. Skin irritation: trial experiments were performed on 100 volunteers between 20 and 45 years old selected for each group of examples 1-8, comparative examples 1-2, and comparative examples 4-5, and no cosmetic product was used for three days before and after the volunteers. The gel mask is uniformly applied on the left cheek half, the left cheek and the right cheek are used as a contrast in the wet application process, the use condition of a volunteer is observed, and the skin condition of a patient within three days when the mask is used is observed. The results obtained are recorded in table 4.
TABLE 3 Table 3
| 30Min cumulative active ingredient release (%) | 10H cumulative active ingredient release (%) | |
| Example 1 | 52.61 | 85.86 |
| Example 2 | 56.82 | 86.63 |
| Example 3 | 63.08 | 78.29 |
| Example 4 | 55.05 | 81.06 |
| Example 5 | 60.03 | 74.58 |
| Example 6 | 61.13 | 75.63 |
| Example 7 | 56.16 | 84.47 |
| Example 8 | 51.28 | 77.47 |
| Comparative example 1 | 61.13 | 70.09 |
| Comparative example 2 | 62.17 | 73.97 |
| Comparative example 4 | 53.35 | 86.31 |
| Comparative example 5 | 45.66 | 67.39 |
TABLE 4 Table 4
| Irritation (human) | Red (human) | Acne (human) | Drying (human) | |
| Example 1 | 0 | 0 | 0 | 0 |
| Example 2 | 0 | 1 | 0 | 0 |
| Example 3 | 0 | 0 | 0 | 0 |
| Example 4 | 0 | 0 | 0 | 0 |
| Example 5 | 0 | 0 | 1 | 0 |
| Example 6 | 0 | 1 | 0 | 0 |
| Example 7 | 0 | 0 | 0 | 0 |
| Example 8 | 0 | 0 | 0 | 0 |
| Comparative example 1 | 0 | 0 | 2 | 0 |
| Comparative example 2 | 0 | 0 | 0 | 0 |
| Comparative example 4 | 3 | 2 | 1 | 0 |
| Comparative example 5 | 2 | 1 | 0 | 1 |
As can be seen from the results in Table 3, the gel masks prepared in examples 1 to 8 have an active ingredient release amount of 51.28% or more in 30 minutes and an active ingredient release amount of 74.58% or more in 10 hours, and the active ingredient release effect is good.
The concentration of the natural polysaccharide aqueous solution in comparative example 1 is too high, the release amount of the active ingredient reaches 61.13% at 30min, but the release amount of the active ingredient is only 70.09% at 10h, because the viscosity of the solution is higher when the concentration of the natural polysaccharide aqueous solution is higher, the penetration of the ionic crosslinking agent is not facilitated, a compact gel structure is formed on the surface layer, but the inside is loose, and the slow release of the active ingredient is not facilitated. Comparative example 2 is similar to the case of comparative example 1 in that the active ingredient is rapidly released in a short time, because the concentration of the ionic crosslinking agent in comparative example 2 is too high, a dense crosslinked network is rapidly formed on the surface, and the penetration of the ionic crosslinking agent is affected, so that the inside of the gel mask is loose, and the slow release of the active ingredient is not facilitated.
Meanwhile, in comparative example 5, a conventional gel mask method was adopted, in which a natural polysaccharide aqueous solution carrying an active ingredient and an ionic crosslinking agent aqueous solution carrying a permeation enhancer were uniformly stirred and then formed into a gel mask. As can be seen from table 3, the release amounts of the functional components in comparative example 5 are lower in both 30min and 10h, the early release rate is slower, and the overall release amount is lower, which is probably due to the fact that the gel mask prepared by the conventional method forms a more complete and compact gel structure in the gel forming process, and the structure seals the components in the gel mask more firmly, which is unfavorable for the release of the functional components. However, the release amount of the active ingredient in the embodiment 1 with the same formulation as that in the comparative example 5 is significantly higher than that in the comparative example 5 in 30min and 10h, which is probably due to the fact that in the embodiment 1, the gel is gradually formed from the surface to the inside by coating the natural polysaccharide aqueous solution on the skin surface and then spraying the ionic cross-linking agent aqueous solution, and the gel forming manner may cause the gel structure to form a channel similar to a "horn" shape, that is, the smaller the caliber of the channel near the surface is, the larger the caliber of the channel is, and the "horn" shape channel is beneficial to release of the active ingredient and moisture to the skin. The comparison of comparative example 5 and example 1 also shows that the preparation mode of spraying before coating proposed by the invention greatly improves the release amount of active substances.
As can be seen from Table 4, in examples 1 to 8 and comparative examples 1 to 2, the addition of the active ingredient to the aqueous solution of natural polysaccharide and the addition of the permeation enhancer to the aqueous solution of ionic crosslinking agent resulted in fewer volunteers who had developed adverse phenomena when the mask was used and after three days of observation, and only 3 people had developed reddening and acne, which was also related to the skin condition or diet of the volunteers themselves. Comparative example 1 shows a poxy appearance in two persons in three days of observation, which may be related to the volunteer's own situation, but may also be caused by an excessively high concentration of the natural aqueous polysaccharide solution in comparative example 1. In the comparative example 4, the active ingredient and the permeation enhancer are added into the natural polysaccharide water solution, and the comparative example 5 is directly mixed and then molded, in a test group of the gel mask prepared by the two methods, 2-3 volunteers are stimulated in the use process, and the volunteers are reddish, acne and dry in the observation time of three days, the permeation enhancers are uniformly distributed on the side of the mask close to the skin in the modes of both the comparative example 4 and the comparative example 5, so that the permeation enhancers with skin irritation directly contact the skin in a larger dosage, thereby generating irritation. It can also be demonstrated by comparing example 1 with comparative examples 4-5 that the skin irritation caused by the penetration enhancer can be effectively reduced by adding the active substance and the penetration enhancer into the two solutions respectively and combining the two solutions in a mode of spraying the two solutions.
Claims (5)
1. A method for using a mild gel mask for non-therapeutic purposes, wherein the mild gel mask comprises a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, the natural polysaccharide aqueous solution comprises natural polysaccharide, an active ingredient and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, a permeation enhancer and water;
the natural polysaccharide is selected from one or a combination of a plurality of sodium alginate, potassium alginate and lithium alginate;
The ionic crosslinking agent is calcium gluconate;
The mass ratio of the natural polysaccharide to the water is (2-6): 100, the mass ratio of the ionic cross-linking agent to water is (1-2): 100;
The volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution is 1: (0.5-1);
The penetration enhancer is azone; the mass concentration of the azone in the ionic crosslinking aqueous solution is 1-2%;
The mild gel mask is used as follows:
(1) Adding natural polysaccharide and active ingredients into deionized water simultaneously or in batches, and stirring until the natural polysaccharide and the active ingredients are completely dissolved to obtain a natural polysaccharide aqueous solution;
(2) Adding an ionic crosslinking agent and a permeation enhancer into deionized water simultaneously or in batches, and stirring until the ionic crosslinking agent and the permeation enhancer are completely dissolved to obtain an ionic crosslinking aqueous solution;
(3) Firstly, coating a natural polysaccharide aqueous solution on the surface of skin, then spraying an ionic crosslinking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask.
2. The method for non-therapeutic use of a mild gel mask according to claim 1, wherein said active ingredient is present in an aqueous solution of natural polysaccharide in a concentration of 0.001-5% by mass.
3. The method of using a mild gel mask for non-therapeutic purposes according to claim 1, wherein said active ingredient is selected from one or more of a polypeptide-based component, a collagen-based component, a plant extract-based component, a polysaccharide-based component.
4. The method of using a mild gel mask for non-therapeutic purposes according to claim 3, wherein said polypeptide component is selected from the group consisting of one or more of acetyl hexapeptide-8, palmitoyl tripeptide-1, myristoyl pentapeptide-4, palmitoyl tetrapeptide-7;
The collagen component is selected from one or more of soluble collagen, hydrolyzed collagen and collagen;
the plant extract is selected from one or more of Ginseng radix extract, kava extract, ganoderma extract, and flos Rosae Rugosae extract;
The polysaccharide component is selected from one or more of rhamnose, mannan, beta-glucan, dendrobium polysaccharide, ginseng polysaccharide, oat polysaccharide, tremella polysaccharide, konjak glucomannan, chitosan, galactose and agarose.
5. Use of a mild gel mask according to any one of claims 1 to 4 for the preparation of a mask product having soothing and moisturizing effects.
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| CN115813816A (en) | 2023-03-21 |
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