CN107550753A - A kind of composition and preparation method thereof with skin repair, anti-senescence function - Google Patents
A kind of composition and preparation method thereof with skin repair, anti-senescence function Download PDFInfo
- Publication number
- CN107550753A CN107550753A CN201710963565.3A CN201710963565A CN107550753A CN 107550753 A CN107550753 A CN 107550753A CN 201710963565 A CN201710963565 A CN 201710963565A CN 107550753 A CN107550753 A CN 107550753A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- parts
- skin
- chitosan oligosaccharide
- care compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention belongs to cosmetic technical field, and in particular to a kind of composition and preparation method thereof with skin repair, anti-senescence function.It is provided by the invention that there is skin repair, the skin care compositions of anti-senescence function, including following component and its mass fraction：33 47 parts of chitosan oligosaccharide, acylated 36 parts of 10 20 parts of chitosan oligosaccharide, 20 30 parts of chitosan, 22 38 parts of carboxymethyl chitosan, 10 15 parts of beta glucan and schizophan.Provided by the invention have that skin repair, the composition of anti-senescence function are safe to use, and property is gentle, no skin irritatin, without allergic.In addition, it can also supplement Skin Cell nutrient, reach deep layer reparation, promote the effect of cell metabolism, active cell vigor, there is preferable antibacterial, moisturizing, anti-ageing function of waiting for a long time to skin.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of to have skin repair, the composition of anti-senescence function
And preparation method thereof.
Background technology
Skin senescence is the physiological phenomenon of human normal, hence it is evident that feature shows as wrinkle occur, body exposure portion skin
Become coarse, wrinkle and deepen overstriking, pigmentation, senile plaque expelling occur, elasticity of skin no longer, become relaxation etc..This mainly by
In with advancing age, fibroblast quantity gradually decreases, synthesizes collagen and elastin laminin in the skin corium of skin
Ability decline, epidermal cell renewal slow down, barrier function weaken, keratinocyte vigor decline, then result in skin
Drying, furfur, wrinkle etc..
At present in the research of skin senescence mechanism, representational explanation is free radical causes of senescence and oxidative stress reason
By the aging of skin is result in body the reason for free radical excess.Body is when by various destructive stimuluses, oxidation rate
Beyond the clearance rate of oxide, oxidative system and antioxidant system are unbalance, that is, the Radical Metabolism in body is in not
During poised state, excessive free radical causes body injury, destroys cell membrane and other important components, causes Lipid peroxidation metabolism,
Cause Protein Damage, cellular matrix synthesis is reduced, and skin follows the string, produces wrinkle.It is logical at present in order to solve this problem
Normal way is that the balance of body internal oxidition system and antioxidant system is kept using radicals scavenging composition, and it can be certain
In degree the problem of delaying skin aging, there is the effect of skin repair.
Chinese patent CN101428037B is disclosed a kind of can act synergistically on containing for human body on multi-level, more sites
The anti-apolexis composition of reparative factor.The composition contains vitamin C, OPC, rhodioside, vitamin B6, dimension life
Plain B1, vitamin B2, nicotinic acid, taurine, arginine, lysine, inositol, zinc salt.
Chinese patent application CN106265130A discloses a kind of composition for skin repair and preparation method thereof, its
Composition of raw materials includes：Porcine HGF 35-50 parts, SOD 1-5 parts, active peptide 1-5 parts, squalene 8-12 parts, ceramide
6-10 parts, carboxymethyl cellulose 12-20 parts, lyase liquid 20-35 parts, microcapsules 15-25 parts, appropriate deionized water.
At present, although there is the product for promoting skin repair, it is poor safety in utilization to be present, is irritating to the skin etc. and to ask
Topic.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of with skin repair, anti-senescence function
Composition and preparation method thereof.It is provided by the invention safe to use with skin repair, the composition of anti-senescence function, property temperature
With, no skin irritatin, without allergic.In addition, it can also supplement Skin Cell nutrient, reach deep layer reparation, promote cell
The effect of metabolism, active cell vigor, there is preferable antibacterial, moisturizing, anti-ageing function of waiting for a long time to skin.
The technical scheme is that：
It is a kind of that there is skin repair, the skin care compositions of anti-senescence function, including following component and its mass fraction：Shell is few
Sugared 33-47 parts, acylated chitosan oligosaccharide 10-20 parts, chitosan 20-30 parts, carboxymethyl chitosan 22-38 parts, beta glucan 10-15 parts
With schizophan 3-6 parts.
Further, it is described that there is skin repair, the skin care compositions of anti-senescence function, by following component and its mass parts
Array into：42 parts of chitosan oligosaccharide, it is acylated 14 parts of chitosan oligosaccharide, 26 parts of chitosan, 30 parts of carboxymethyl chitosan, 13 parts of beta glucan and splits
5 parts of pleat polysaccharide.
Further, the chitosan oligosaccharide molecular weight is 1500-2000Da, and acylated chitosan oligosaccharide molecular weight is 1500-2000Da,
Chitosan molecule amount is 40000-50000Da, and carboxymethyl chitosan molecular weight is 3000-3500Da.
Further, the chitosan oligosaccharide molecular weight is 1700Da, and acylated chitosan oligosaccharide molecular weight is 1800Da, and chitosan divides
Son amount is 44000Da, and carboxymethyl chitosan molecular weight is 3350Da.
Further, the chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 85%-
95%.
Further, the chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are
90%.
In addition, present invention also offers the described preparation side with skin repair, the skin care compositions of anti-senescence function
Method, comprise the following steps：
S1：Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan are taken by definite quality number and are split
Pleat polysaccharide, and the acetic acid deionized water solution that volumetric concentration is 1.5%-2.5% is added, obtain component liquid A；
S2：Component liquid A made from step S1 is placed on magnetic stirring apparatus, rotating speed be 100-150r/min, temperature be
60-80min is stirred under conditions of 60-80 DEG C, obtains mixed liquid B；
S3：Mixed liquid B made from step S2 is incubated 10-30min at 60-80 DEG C, obtains mixed liquor C；
S4：Mixed liquor C made from step S3 is cooled to room temperature, produced.
Further, the addition of the step S1 acetic acid deionized water solutions is that chitosan oligosaccharide, acylated chitosan oligosaccharide, shell gather
Sugar, carboxymethyl chitosan, 6-20 times of beta glucan and schizophan gross mass.
Further, the addition of the step S1 acetic acid deionized water solutions is that chitosan oligosaccharide, acylated chitosan oligosaccharide, shell gather
Sugar, carboxymethyl chitosan, 12 times of beta glucan and schizophan gross mass.
Further, the step S1 and add volumetric concentration be 2% acetic acid deionized water solution.
Further, the step S2 stirs 70min under conditions of rotating speed is 120r/min, temperature is 70 DEG C.
Further, mixed liquid B made from step S2 is incubated 25min at 70 DEG C in the step S3.
Composition provided by the invention with skin repair, anti-senescence function is gathered by chitosan oligosaccharide, acylated chitosan oligosaccharide, shell
Sugar, carboxymethyl chitosan, beta glucan and schizophan etc. are prepared.Wherein, chitosan oligosaccharide has good water solubility, can
The performance of keeping humidity of product fine is assigned, in addition, it can also absorb ultraviolet, eliminate free radical, activating cell, is had well
Anti-oxidant, the anti-ageing effect of waiting for a long time, make obtained product that there is whitening, crease-resistant and other effects, be harmful to meanwhile, it is capable to suppress skin surface
Bacterium grows, and promotes the healing of skin, eliminates scar and acne print.Acylated chitosan oligosaccharide makes product have the same of good moisture retention
When, strengthen the stability of product.Chitosan has excellent water imbibition and water-retaining property, not only can provide nutritional ingredient to skin
Such as collagen, but also can stimulate accelerate epidermal cell reproduction speed, with reach delaying senility, beauty effect,
In addition, chitosan can also improve the film forming of product, have antibacterial, moisturizing, anti-aging and promote the work(such as wound healing
Can, and do not cause any allergic stimulated to be reacted.Carboxymethyl chitosan has excellent moisture retention, dissolubility, stability and wide
General adaptability, and it is safe and non-toxic, it is biodegradable, feature, security and the applicability of obtained product can be strengthened.
Beta glucan possesses excellent senile-resistant efficacy, can smooth fine wrinkles, improves dermatoglyph degree, its unique straight chain molecule
Structure, the good percutaneous absorbtion performance of product is imparted, can given skin as the release vehicle of composition and light is moistened such as silk
Sliding sense of touch.Obtained by isolating and purifying and being freeze-dried after schizophan is fermented by schizophyllum commune in the present invention, viscosimetry is surveyed
It is 187000 to obtain its relative molecular mass, and it can strengthen the performance of keeping humidity of product.Various composition is mutually coordinated in the present invention, mends
Skin Cell nutrient is filled, reaches deep layer reparation, promote the effect of cell metabolism, active cell vigor, promotes skin to repair newborn,
Local nutrition is supplemented, accelerates lesion healing process, preventing from scar and acne print, there is preferable moisturizing, anti-ageing function of waiting for a long time.
Compared with prior art, it is provided by the invention with skin repair, anti-senescence function composition with following excellent
Gesture：
(1) it is provided by the invention that there is skin repair, the composition of anti-senescence function can promote skin repair, accelerate damage
Hinder agglutination, preventing from scar and acne print.
(2) provided by the invention safe to use with skin repair, the composition of anti-senescence function, property is gentle, no skin
Skin stimulates, without allergic.
(3) it is provided by the invention that there is skin repair, the composition of anti-senescence function can supplement Skin Cell nutrient, protect
Skin water profit elasticity is held, makes skin moist, keeps cell moisture, reaches deep layer reparation, promote cell metabolism, active cell
The effect of vigor, there is preferable antibacterial, moisturizing, anti-ageing function of waiting for a long time to skin.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art according to the present invention basic thought, various modifications may be made or improve, but without departing from this
The basic thought of invention, within the scope of the present invention.
Embodiment 1, it is a kind of have skin repair, the skin care compositions of anti-senescence function
It is described that there is skin repair, the skin care compositions of anti-senescence function to be made up of following component and its mass fraction：Point
Son amount be 1500Da 33 parts of chitosan oligosaccharide, molecular weight be 1500Da 10 parts of acylation chitosan oligosaccharide, molecular weight be 40000Da shell gather
20 parts of sugar, 10 parts of 22 parts of carboxymethyl chitosan, the beta glucan and 3 parts of schizophan that molecular weight is 3000Da；The chitosan oligosaccharide,
Acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 85%.
Preparation method：
S1：Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan are taken by definite quality number and are split
Pleat polysaccharide, and the acetic acid deionized water solution that volumetric concentration is 1.5% is added, the addition of acetic acid deionized water solution is few for shell
Sugar, be acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan and schizophan gross mass 6 times, obtain component liquid A；
S2：Component liquid A made from step S1 is placed on magnetic stirring apparatus, rotating speed be 100r/min, temperature be 60 DEG C
Under conditions of stir 60min, obtain mixed liquid B；
S3：Mixed liquid B made from step S2 is incubated 10min at 60 DEG C, obtains mixed liquor C；
S4：Mixed liquor C made from step S3 is cooled to room temperature, produced.
Embodiment 2, it is a kind of have skin repair, the skin care compositions of anti-senescence function
It is described that there is skin repair, the skin care compositions of anti-senescence function to be made up of following component and its mass fraction：Point
Son amount be 2000Da 47 parts of chitosan oligosaccharide, molecular weight be 2000Da 20 parts of acylation chitosan oligosaccharide, molecular weight be 50000Da shell gather
30 parts of sugar, 15 parts of 38 parts of carboxymethyl chitosan, the beta glucan and 6 parts of schizophan that molecular weight is 3500Da；The chitosan oligosaccharide,
Acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 95%.
Preparation method：
S1：Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan are taken by definite quality number and are split
Pleat polysaccharide, and the acetic acid deionized water solution that volumetric concentration is 2.5% is added, the addition of acetic acid deionized water solution is few for shell
Sugar, be acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan and schizophan gross mass 20 times, obtain component liquid A；
S2：Component liquid A made from step S1 is placed on magnetic stirring apparatus, rotating speed be 150r/min, temperature be 80 DEG C
Under conditions of stir 80min, obtain mixed liquid B；
S3：Mixed liquid B made from step S2 is incubated 30min at 80 DEG C, obtains mixed liquor C；
S4：Mixed liquor C made from step S3 is cooled to room temperature, produced.
Embodiment 3, it is a kind of have skin repair, the skin care compositions of anti-senescence function
It is described that there is skin repair, the skin care compositions of anti-senescence function to be made up of following component and its mass fraction：Point
Son amount be 1700Da 42 parts of chitosan oligosaccharide, molecular weight be 1800Da 14 parts of acylation chitosan oligosaccharide, molecular weight be 44000Da shell gather
26 parts of sugar, 13 parts of 30 parts of carboxymethyl chitosan, the beta glucan and 5 parts of schizophan that molecular weight is 3350Da；The chitosan oligosaccharide,
Acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 90%.
Preparation method：
S1：Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan are taken by definite quality number and are split
Pleat polysaccharide, and the acetic acid deionized water solution that volumetric concentration is 2% is added, the addition of acetic acid deionized water solution is few for shell
Sugar, be acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan and schizophan gross mass 12 times, obtain component liquid A；
S2：Component liquid A made from step S1 is placed on magnetic stirring apparatus, rotating speed be 120r/min, temperature be 70 DEG C
Under conditions of stir 70min, obtain mixed liquid B；
S3：Mixed liquid B made from step S2 is incubated 25min at 70 DEG C, obtains mixed liquor C；
S4：Mixed liquor C made from step S3 is cooled to room temperature, produced.
Comparative example 1, it is a kind of have skin repair, the skin care compositions of anti-senescence function
It is described that there is skin repair, the skin care compositions of anti-senescence function to be made up of following component and its mass fraction：Point
Son amount be 1700Da 42 parts of chitosan oligosaccharide, molecular weight be 1800Da 14 parts of acylation chitosan oligosaccharide, molecular weight be 44000Da shell gather
26 parts of sugar, 13 parts of 30 parts of carboxymethyl chitosan, the 2-Acetamido-2-deoxy-D-glucose and 5 parts of schizophan that molecular weight is 3350Da；Institute
It is 90% to state chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan.
Preparation method is similar to Example 3.
As different from Example 3, beta glucan is replaced with into 2-Acetamido-2-deoxy-D-glucose.
Comparative example 2, it is a kind of have skin repair, the skin care compositions of anti-senescence function
It is described that there is skin repair, the skin care compositions of anti-senescence function to be made up of following component and its mass fraction：Point
Son amount be 1700Da 42 parts of chitosan oligosaccharide, molecular weight be 1800Da 14 parts of acylation chitosan oligosaccharide, molecular weight be 44000Da shell gather
26 parts of sugar, 13 parts of 30 parts of carboxymethyl chitosan, the beta glucan and 5 parts of aloe polysaccharide that molecular weight is 3350Da；The chitosan oligosaccharide,
Acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 90%.
Preparation method is similar to Example 3.
As different from Example 3, schizophan is replaced with into aloe polysaccharide.
Test example one, moisture retention testing experiment
1st, test material：Prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 repaiies with skin
The multiple, skin care compositions of anti-senescence function.
2nd, subjects：60 health volunteers.
3rd, test method：By 60 health volunteers, 6 groups are randomly divided into, every group of 10 people, respectively control group, embodiment 1
2 groups of group, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and comparative example, forearm is cleaned with unified gentle cleaning agent before experiment
Side skin is bent, sit quietly 30min in constant environment, then detects each experiment position with digital skin moisture detector, respectively
It is repeated 3 times, draws its average value；Then physiological saline, embodiment 1, embodiment 2, embodiment 3, comparative example 1, right is smeared respectively
Prepared by ratio 2 has skin repair, the skin care compositions of anti-senescence function in each experiment position, often locate pilot region be 2 ×
2cm2, 15min, 30min, 45min, 60min, 90min and 120min are detected respectively again at these positions after smearing.Will be every
The average value of secondary detection subtract before not smearing be period position measured value.
4th, result of the test：
Result of the test is as shown in table 1.
Table 1：Moisture retention test result
As shown in Table 1, what prepared by the smearing embodiment of the present invention 1, embodiment 2, embodiment 3 has skin repair, anti-aging
After the skin care compositions of function, the moisture of skin has obvious increase, illustrates provided by the invention with skin repair, anti-aging
The skin care compositions of function has good moisture retention, and the moistening effect of embodiment 3 is optimal, for the optimal implementation of the present invention
Example；Compared with comparative example 1, comparative example 2, the moistening effect of embodiment 3 is more notable.
Test example two, anti-aging effects evaluation
1st, given the test agent：The obtained skin care with skin repair, anti-senescence function of embodiment 1, embodiment 2, embodiment 3
Composition.
2nd, experimental animal：80 kunming mices for taking health, 9-11 week old, body weight 40g, male and female half and half.
3rd, test method：
Kunming mice is randomly divided into 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, blank control group, every group 20,
Male and female half and half, it is obtained with skin repair, anti-senescence function that embodiment 1, embodiment 2, embodiment 3 are smeared during experiment respectively
Skin care compositions, blank control group smear physiological saline.
Each group mouse is lost hair or feathers with 0.8% vulcanized sodium back, exposure 4cm × 4cm test section.Before smearing given the test agent
Skin first is cleaned with warm water, daily night smears once has skin repair, the skin care compositions of anti-senescence function accordingly, even
It is continuous to smear one month, the mouse hair newly grown is during which shaved off in time.After last smears 12h, clip mouse test section skin histology, system
Preserved skin skin tissue homogenate, determine superoxide dismutase (SOD) vigor and MDA (MDA) content.
4th, result of the test：
Result of the test is as shown in table 2.
Table 2：SOD vigor, MDA contain during skin care compositions with skin repair, anti-senescence function is homogenized to skin histology
The influence of amount
| Group | SOD(U/mgprot) | MDA(nmol/mgprot) |
| Blank control group | 118.95 | 3.76 |
| 1 group of embodiment | 169.72 | 2.48 |
| 2 groups of embodiment | 175.43 | 2.55 |
| 3 groups of embodiment | 182.15 | 2.32 |
As can be seen from Table 2, it is obtained with skin repair, the skin care compositions of anti-senescence function to apply a 1-3 by the present invention
The vigor of SOD in skin is remarkably improved, reduces MDA content, this explanation is provided by the invention to have skin repair, anti-ageing
The skin care compositions of old function has good anti-aging effects, and the anti-aging effects of embodiment 3 are optimal, for the present invention most
Good embodiment.
Test example three, safety evaluatio
1st, tested material：Embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 be obtained have skin repair,
The skin care compositions of anti-senescence function.
2nd, study subject：
100 trial volunteers, age 26-50 year, subjects skin's health, no skin disease allergies, meet subject
Volunteer inclusion criteria.
3rd, test method：
100 trial volunteers are randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, contrast
2 groups of 1 group of example and comparative example, every group of 20 people, respectively using embodiment 1, embodiment 2,
Embodiment 3, comparative example 1 and comparative example 2 are obtained to have skin repair, the skin care compositions of anti-senescence function.
Device is tried from qualified spot, with closed patch experiment method, 0.020g tested materials are added in spot examination device, external application
Special adhesive tape is covered on subject back, and tested material is removed after 24h, 0.5h, 6h, 12h, 24h, 48h observation skin after removing respectively
Skin reacts, according to《Cosmetics health specification》Middle dermoreaction grade scale records its result.
4th, result of the test：
Human skin patch result is shown：The tool that each group subject passes through embodiment 1-3, comparative example 1 and comparative example 2
Have skin repair, anti-senescence function skin care compositions patch test, 0.5h, 6h, 12h, 24h, 48h observation skin it is anti-
Should, all subjects do not occur skin adverse reaction, and this explanation is produced by the present invention with skin repair, anti-senescence function
Skin care compositions is safe to use.
Test example four, promote skin repair effect
1st, test material：Prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 repaiies with skin
The multiple, skin care compositions of anti-senescence function.
2nd, subjects：Choose 50 female Wistar rats, body weight 250g.
3rd, test method：
50 rats are randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and
2 groups of comparative example, every group 10.
The lcm by rat back backbone both sides, both ends are parallel to backbone one diameter 1.8cm of each mark, area end to end
2.54cm2Circular incision line.After iodophor disinfection skin, full thickness skin is wiped out to deep fascia along mark line with scissors, forms 4
The individual circular surface of a wound.Embodiment 1 is smeared in left side respectively, prepared by embodiment 2, embodiment 3, comparative example 1 and comparative example 2 has skin
Repair, the skin care compositions of anti-senescence function, right side wound is covered with gauze and wrapped up without handling as a control group.Even
Continuous observation 10d.
4th, result of the test：
In continuous 10d observation, the wound area of both sides is as shown in table 3 relative to first day wound area.
Table 3：Different time wound area compared relative to first day wound area
| Time | 1d | 2d | 4d | 6d | 8d | 10d |
| 1 group of embodiment | 1 | 0.95 | 0.89 | 0.78 | 0.67 | 0.55 |
| 2 groups of embodiment | 1 | 0.93 | 0.86 | 0.75 | 0.64 | 0.52 |
| 3 groups of embodiment | 1 | 0.91 | 0.82 | 0.71 | 0.62 | 0.46 |
| 1 group of comparative example | 1 | 0.97 | 0.92 | 0.88 | 0.83 | 0.74 |
| 2 groups of comparative example | 1 | 0.96 | 0.90 | 0.86 | 0.78 | 0.69 |
| Control group | 1 | 0.99 | 0.97 | 0.94 | 0.92 | 0.86 |
As shown in Table 3, compared with control group, prepared by the smearing embodiment of the present invention 1, embodiment 2, embodiment 3 has skin
Skin reparation, anti-senescence function skin care compositions after, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment rat wound area
Extension over time is gradually reduced, illustrate the present invention prepare have skin repair, the skin care compositions of anti-senescence function
The best results of skin repair, wherein embodiment 3 can be promoted, be highly preferred embodiment of the present invention；With comparative example 1, comparative example 2
Compare, the skin repair effect of embodiment 3 is the most notable.
Claims (8)
1. a kind of have skin repair, the skin care compositions of anti-senescence function, it is characterised in that including following component and its quality
Number：Chitosan oligosaccharide 33-47 parts, acylated chitosan oligosaccharide 10-20 parts, chitosan 20-30 parts, carboxymethyl chitosan 22-38 parts, β-Portugal gather
Sugared 10-15 parts and schizophan 3-6 parts.
2. there is skin repair, the skin care compositions of anti-senescence function as claimed in claim 1, it is characterised in that by as follows
Component and its mass fraction composition：42 parts of chitosan oligosaccharide, acylated 14 parts of chitosan oligosaccharide, 26 parts of chitosan, 30 parts of carboxymethyl chitosan, β-
5 parts of 13 parts of glucan and schizophan.
3. there is skin repair, the skin care compositions of anti-senescence function as claimed in claim 1 or 2, it is characterised in that described
Chitosan oligosaccharide molecular weight is 1500-2000Da, and acylated chitosan oligosaccharide molecular weight is 1500-2000Da, and chitosan molecule amount is 40000-
50000Da, carboxymethyl chitosan molecular weight are 3000-3500Da.
4. there is skin repair, the skin care compositions of anti-senescence function as claimed in claim 3, it is characterised in that the shell
Oligosaccharide molecular amount is 1700Da, and acylated chitosan oligosaccharide molecular weight is 1800Da, and chitosan molecule amount is 44000Da, carboxymethyl chitosan
Glycan molecule amount is 3350Da.
5. there is skin repair, the skin care compositions of anti-senescence function as claimed in claim 1 or 2, it is characterised in that described
Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 85%-95%.
6. there is skin repair, the skin care compositions of anti-senescence function as claimed in claim 5, it is characterised in that the shell
Oligosaccharides, acylated chitosan oligosaccharide, chitosan, the deacetylation of carboxymethyl chitosan are 90%.
7. the preparation method with skin repair, the skin care compositions of anti-senescence function as described in claim any one of 1-6,
It is characterised in that it includes following steps：
S1：Chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan, beta glucan are taken by definite quality number and to split pleat more
Sugar, and the acetic acid deionized water solution that volumetric concentration is 1.5%-2.5% is added, obtain component liquid A；
S2：Component liquid A made from step S1 is placed on magnetic stirring apparatus, rotating speed be 100-150r/min, temperature 60-80
60-80min is stirred under conditions of DEG C, obtains mixed liquid B；
S3：Mixed liquid B made from step S2 is incubated 10-30min at 60-80 DEG C, obtains mixed liquor C；
S4：Mixed liquor C made from step S3 is cooled to room temperature, produced.
8. the preparation method with skin repair, the skin care compositions of anti-senescence function, its feature exist as claimed in claim 7
In the addition of, step S1 acetic acid deionized water solutions be chitosan oligosaccharide, acylated chitosan oligosaccharide, chitosan, carboxymethyl chitosan,
6-20 times of beta glucan and schizophan gross mass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710963565.3A CN107550753A (en) | 2017-10-17 | 2017-10-17 | A kind of composition and preparation method thereof with skin repair, anti-senescence function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710963565.3A CN107550753A (en) | 2017-10-17 | 2017-10-17 | A kind of composition and preparation method thereof with skin repair, anti-senescence function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107550753A true CN107550753A (en) | 2018-01-09 |
Family
ID=60986396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710963565.3A Pending CN107550753A (en) | 2017-10-17 | 2017-10-17 | A kind of composition and preparation method thereof with skin repair, anti-senescence function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107550753A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481326A (en) * | 2018-11-19 | 2019-03-19 | 珠海伊斯佳科技股份有限公司 | A kind of after-sun recovery Essence |
| CN110038155A (en) * | 2019-04-11 | 2019-07-23 | 陕西仁浩医疗器械有限公司 | A kind of medical gel promoting wound healing |
| CN110638718A (en) * | 2019-10-25 | 2020-01-03 | 广东密尚生物科技有限公司 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
| CN113559014A (en) * | 2021-08-24 | 2021-10-29 | 上海陶盛生物技术有限公司 | Application of carboxymethyl chitosan in promoting fibroblast proliferation and increasing collagen content |
| CN113730283A (en) * | 2021-10-14 | 2021-12-03 | 扬州日兴生物科技股份有限公司 | Natural moisturizing and bacteriostatic facial mask containing compound functional chitosan |
| CN114224778A (en) * | 2021-12-27 | 2022-03-25 | 广东丸美生物技术股份有限公司 | Schizophyllum commune polysaccharide composition and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560160A (en) * | 2016-03-16 | 2016-05-11 | 广州市科玮生物技术有限公司 | Facial mask essence containing chitosan and preparation method thereof |
-
2017
- 2017-10-17 CN CN201710963565.3A patent/CN107550753A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560160A (en) * | 2016-03-16 | 2016-05-11 | 广州市科玮生物技术有限公司 | Facial mask essence containing chitosan and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 冯延民: "《壳寡糖与人类健康》", 31 March 2008, 吉林大学出版社 * |
| 郭远祀等: "《溶液过程理论与电磁处理技术》", 31 July 2009, 华南理工大学出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481326A (en) * | 2018-11-19 | 2019-03-19 | 珠海伊斯佳科技股份有限公司 | A kind of after-sun recovery Essence |
| CN110038155A (en) * | 2019-04-11 | 2019-07-23 | 陕西仁浩医疗器械有限公司 | A kind of medical gel promoting wound healing |
| CN110638718A (en) * | 2019-10-25 | 2020-01-03 | 广东密尚生物科技有限公司 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
| CN113559014A (en) * | 2021-08-24 | 2021-10-29 | 上海陶盛生物技术有限公司 | Application of carboxymethyl chitosan in promoting fibroblast proliferation and increasing collagen content |
| CN113730283A (en) * | 2021-10-14 | 2021-12-03 | 扬州日兴生物科技股份有限公司 | Natural moisturizing and bacteriostatic facial mask containing compound functional chitosan |
| CN114224778A (en) * | 2021-12-27 | 2022-03-25 | 广东丸美生物技术股份有限公司 | Schizophyllum commune polysaccharide composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107550753A (en) | A kind of composition and preparation method thereof with skin repair, anti-senescence function | |
| CN109431841B (en) | Antioxidant and anti-aging whitening essence and preparation method thereof | |
| CN105168112A (en) | Anti-wrinkle toner and preparation method thereof | |
| CN111067816A (en) | Moisturizing and repairing mask containing active polypeptide and preparation method thereof | |
| CN105411919A (en) | Skin caring product made from roses and preparation method thereof | |
| CN103110935B (en) | Hydrolyzed collagen liposome for local skin and preparation method thereof | |
| CN107714559A (en) | One kind is without anti-corrosion deep water supplement skin care item | |
| CN107137760A (en) | A kind of moisturizing maintenance dressing and preparation method thereof | |
| CN106511215A (en) | Eye cream with effects of moisturizing and wrinkle resistance and preparation method of eye cream | |
| CN104958241A (en) | Moisturizing traditional Chinese medicine mask product and preparation method thereof | |
| CN109793668A (en) | A kind of eye mask and its application | |
| CN112656709A (en) | Skin care compositions and uses thereof | |
| CN108186464A (en) | A kind of skin repair hydrogel facial mask and preparation method thereof | |
| CN111467258A (en) | Antioxidant and anti-aging whitening gel and preparation method thereof | |
| CN110833519A (en) | Soothing and moisturizing mask liquid containing industrial hemp leaf extract and preparation method thereof | |
| KR20180069487A (en) | Hydrogel comprising spicule and use thereof | |
| CN109464364A (en) | A kind of spot removal and skin care preparation and preparation method containing graphene oxide | |
| CN112999105A (en) | High-moisturizing essence lotion and preparation method thereof | |
| CN111728924A (en) | Whitening mask and preparation method thereof | |
| CN110496069A (en) | A kind of poly- peptide stoste of small molecule and preparation method thereof | |
| CN108261379A (en) | A kind of facial mask and preparation method thereof | |
| CN112807268B (en) | Non-greasy make-up and food-homologous aloe gel derived from raw juice and preparation method thereof | |
| CN108703895A (en) | A kind of long-acting moisturizing gel and preparation method of percdation | |
| CN107753354A (en) | Anti-aging moisturizing skin care product containing stem cell growth factors and application thereof | |
| KR20140145274A (en) | Composition for skin moisturizing containing oxygen dissolving water with a polymer composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180109 |
|
| RJ01 | Rejection of invention patent application after publication |