CN111467258A

CN111467258A - Antioxidant and anti-aging whitening gel and preparation method thereof

Info

Publication number: CN111467258A
Application number: CN202010468605.9A
Authority: CN
Inventors: 许文斌
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-28
Filing date: 2020-05-28
Publication date: 2020-07-31

Abstract

The invention discloses an antioxidant and anti-aging whitening gel and a preparation method thereof, wherein the whitening gel comprises a first matrix, a second matrix and a base solution, and the first matrix comprises the following components in parts by mass: 6-10 parts of glycerol, 0.5-1 part of carbomer, 0.1-1 part of triethanolamine and 0.1-1 part of polydimethylsiloxane, wherein the second matrix comprises the following components in parts by mass: 30-50 parts of chitosan and 30-50 parts of gelatin. According to the invention, through the arrangement of the base liquid, the second matrix and the first matrix, the thermosensitive release base liquid of the second matrix enters the first matrix, the gel slowly and uniformly releases effective components, the action time of the components is prolonged, the adaptability of the skin to the gel is improved, the absorption and utilization of the gel by the skin are promoted, and the addition of multiple components and the mutual promotion among the components inhibit the activity of free radicals and eliminate the free radicals, inhibit the generation of melanin, promote metabolism and eliminate the peeled melanin, so that the effects of antioxidation, anti-aging and whitening of the gel are realized, and the gel is suitable for wide popularization and use.

Description

Antioxidant and anti-aging whitening gel and preparation method thereof

Technical Field

The invention relates to the field of gel, in particular to an antioxidant and anti-aging whitening gel and a preparation method thereof.

Background

The gel is a dispersion system, and is formed by connecting sol, colloidal particles in solution or macromolecules under certain conditions to form a spatial network structure, and liquid serving as a dispersion medium is filled in structural gaps. The antioxidant and anti-aging are the topics which are not changed for a long time in the skin care industry, aging is the direct expression of the function of a human body to be slowed, excessive oxidation can accelerate aging and generate pigmentation, the antioxidant component in the existing skin care product has a single system, and the anti-aging effect can be observed only by long-time accumulation. Therefore, the whitening gel with the functions of resisting oxidation and ageing and the preparation method thereof are provided.

Disclosure of Invention

The invention aims to provide an antioxidant and anti-aging whitening gel and a preparation method thereof, and aims to solve the problems in the prior art.

In order to achieve the purpose, the invention provides the following technical scheme: the whitening gel has the following components in parts by mass: 6-10 parts of glycerol, 0.5-1 part of carbomer, 0.1-1 part of triethanolamine and 0.1-1 part of polydimethylsiloxane, wherein the second matrix comprises the following components in parts by mass: 30-50 parts of chitosan, 30-50 parts of gelatin and 1-10 parts of poly (isopropyl acrylamide), wherein the base solution comprises the following components in parts by mass: 0.01-0.1 part of squalane, 0.01-0.05 part of idebenone, 0.01-0.1 part of cyclodextrin, 0.01-0.1 part of fullerene, 0.5-1 part of polyflavonoside, 0.5-2 parts of polypeptide, 0.2-0.5 part of phycocyanin, 0.1-0.4 part of trehalose, 0.5-1 part of organic silicon and 0.002-0.005 part of polyquaternary ammonium salt.

In the technical scheme, carbomer provides a basic framework with excellent hydrophilicity and transparency for gel, glycerin has a good moisturizing effect, so that skin cells are swelled and soft, and the absorption capacity of skin on skin care products is improved;

the chitosan and the gelatin are blended to form a basic frame of the second substrate, the transparency is high, the elasticity is good, the moisture retention performance is excellent, the poly-isopropyl acrylamide and the glycerol improve the sensitivity of the mask substrate to the temperature, so that the mask substrate can generate volume change within the temperature range of a human body, and the precipitation of mask base liquid is promoted;

squalane and idebenone both have antioxidant capacity, squalane inhibits peroxidation of skin lipid, promotes proliferation of skin basal cells, delays skin aging, idebenone has smaller molecules and better penetration capacity on skin, prevents free radicals from attacking healthy cells, cyclodextrin can absorb grease, enhances cleaning capacity of gel, eliminates bad gases in gel, simultaneously improves safety of gel, inhibits enzyme activity by fullerene, attracts free radicals on the surface of skin, achieves the purposes of oxidation resistance and aging resistance, and has the functions of resisting oxidation and absorbing red light, promoting secretion of collagen, removing wrinkles and tendering skin, polypeptide can promote cell metabolism, stimulate cell activity, achieve the effect of aging resistance, organic silicon can improve dispersion degree of gel basal liquid, increase silky feeling of products, and delay skin drying time, the polyquaternium can inhibit the generation of foam in a system and increase the viscosity of the system.

The first matrix as a preferred embodiment of the present invention further comprises the following mass components: 1-5 parts of propylene glycol, 1-5 parts of pentaerythritol tetraisostearate and 0.1-1 part of octyl glycol, wherein the propylene glycol is 1, 3-propylene glycol.

In the technical scheme, the propylene glycol contains hydroxyl, can combine with water to achieve a moisturizing effect, dissolves dirt in skin, assists penetration of active ingredients, can improve the antiseptic effect of the gel, can reduce the viscosity of glycerin, enables the gel to be more refreshing and comfortable, does not cause allergy and irritation reaction to the skin due to the 1, 3-propylene glycol, is more friendly to the skin compared with the 1, 2-propylene glycol, improves the softness and the use feeling of the gel due to pentaerythritol tetraisostearate, can improve the moisturizing and antibacterial abilities of the gel due to the caprylic glycol, softens a system, and endows the gel matrix with better touch feeling.

As a preferred embodiment of the present invention, the base fluid further comprises the following components by mass: 0.05-0.1 part of lipoic acid, 0.1-0.5 part of laureth-7, 1-2 parts of vitamin C ethyl ether and 0.01-0.02 part of astaxanthin.

In the technical scheme, the lipoic acid can reduce the metabolism of vitamin C and vitamin E, so that an antioxidant effect is achieved, the oxygen-containing state of cells is maintained, the activity of the cells is improved, the laureth-7 has good decontamination and hard water resistance, the gel is not influenced by residual hard water on the surface of the skin while the gel cleaning capacity is improved, the vitamin C ethyl ether can inhibit the activity of tyrosinase, the generation of melanin is prevented, the whitening effect is achieved, the vitamin C ethyl ether can enter the dermis layer from the horny layer of the skin, the activity of the cells is improved, the increase of collagen is promoted, the skin is rich in elasticity, the anti-wrinkle effect is achieved, the astaxanthin can eliminate free radicals, unstable oxygen molecules are eliminated, the oxidative damage of ultraviolet rays is avoided, and the antioxidant and anti-aging effects are achieved.

In a preferred embodiment of the present invention, the polyquaternium is one or more of polyquaternium-10 and polyquaternium-7, and the organosilicon is methylsilanol mannuronate.

In the technical scheme, the polyquaternium-10 and the polyquaternium-7 are both ionic surfactants, and when the polyquaternium-10 and the polyquaternium-7 are in the same system and are blended with the methylsilanol mannuronate, the system tends to be negatively charged, the permeation of gel to skin is promoted, the antioxidation, anti-aging and whitening capabilities of the gel are improved, meanwhile, the polyquaternium improves the viscosity of the gel, and the methylsilanol mannuronate can increase the silky feeling of the gel and delay the drying time of the skin.

As a preferred embodiment of the invention, the polypeptide is one or more of glutathione, pentapeptide, hexapeptide and nonapeptide-1.

In the technical scheme, nonapeptide-1 in the polypeptide can be matched with a receptor on melanin to resist melanocyte stimulating hormone, prevent tyrosinase from being further activated to generate melanin, act on an epidermal layer to inhibit melanocyte stimulating hormone and achieve the effect of whitening; the Wushengtai and the Hehengtai can inhibit the decomposition of elastin, promote the formation of collagen and achieve the effects of moisturizing and resisting wrinkles; the glutathione has antioxidant capacity, can be combined with heavy metal, prevents cells from being damaged by free radicals or peroxide when contacting with skin, and absorbs the residual heavy metal in the skin, and can achieve the effects of beautifying and protecting skin by single use or multiple combinations.

As a preferred embodiment of the present invention, the molecular weight of the polydimethylsiloxane is 100-500.

In the technical scheme, the polydimethylsiloxane can promote the uniform dispersibility of the dispersing agent in the system, and the texture and the use feeling of the gel are improved, so that the gel is fresh and is not sticky.

A preparation method of the whitening gel with the functions of oxidation resistance and aging resistance comprises the following steps:

1) preparing a base solution;

2) preparing a first matrix;

3) preparing a second matrix;

4) a gel was prepared.

As a preferred embodiment of the present invention, the method comprises the following steps:

1) preparing a base liquid:

a) synthesizing a base solution;

b) preparing an emulsion;

2) preparing a first matrix;

3) preparing a second matrix:

a) preparing a second matrix precursor;

b) synthesizing a second matrix;

4) a gel was prepared.

1) preparing a base liquid:

a) synthesizing a base solution:

dissolving the flavonoid glycoside in pure water, adding polypeptide, and performing electrophoresis to obtain polypeptide particles;

dissolving phycocyanin and trehalose in buffer solution, heating in water bath to 90-100 deg.C, maintaining the temperature for 24-36h, and cooling to room temperature to obtain modified phycocyanin;

dissolving polyquaternium in pure water to prepare a polyquaternium solution; vacuum drying vitamin C ethyl ether, and dissolving in pure water to obtain vitamin C ethyl ether solution; dissolving lipoic acid in absolute ethyl alcohol to prepare lipoic acid alcohol solution; grinding and mixing a polyquaternary ammonium salt solution, a vitamin C ethyl ether solution, a lipoic acid alcohol solution and organic silicon, respectively adding astaxanthin and polypeptide particles, and fully stirring to prepare a base solution A;

b) preparing an emulsion:

dissolving cyclodextrin in dimethyl sulfone, stirring, heating to 30-70 deg.C, maintaining the temperature, adding fullerene, performing ultrasonic treatment, performing microwave radiation, adding reducing agent, reacting, cooling, cleaning, and drying to obtain modified cyclodextrin;

dissolving modified cyclodextrin in pure water, heating to 40-60 deg.C, keeping the temperature, stirring, slowly adding idebenone, stirring for 30-60min, ultrasonic treating for 5-20min, standing at 4-20 deg.C for 18-24h, and oven drying at 40-50 deg.C to obtain clathrate B;

adding stearic acid, squalane, lecithin and the inclusion compound B into a same reaction kettle, heating and stirring at 79-85 ℃ to prepare a lipid solution, heating and stirring pure water and laureth-7 at 79-85 ℃ to prepare an aqueous solution, slowly adding the aqueous solution into the lipid solution, standing, placing in a water bath at 79-85 ℃, stirring and carrying out ultrasonic treatment for 1-5min, stirring and dispersing the obtained liquid in pure water at the temperature of 2-3 ℃, and dehydrating to obtain emulsion C;

2) preparing a first matrix:

heating capryl glycol to 53-55 ℃, adding propylene glycol and glycerol, stirring uniformly, adding polydimethylsiloxane, stirring uniformly to obtain a mixed solution D, adding carbomer into pure water, stirring uniformly, standing for 12-24h, adding the mixed solution D, stirring uniformly, slowly adding triethanolamine to adjust the consistency and viscosity of a matrix, and adding pentaerythritol tetraisostearate to obtain a first matrix;

3) preparing a second matrix:

a) preparing a second matrix precursor:

dissolving chitosan in citric acid solution, stirring, standing for defoaming to obtain chitosan solution, adding gelatin into distilled water, heating and stirring to dissolve completely to obtain gelatin solution, slowly adding gelatin solution into chitosan solution, heating, and stirring until the solution is transparent liquid;

b) synthesizing a second matrix:

adding a glycerol solution into the chitosan/gelatin solution for blending, continuing to heat, adding the mixed solution D and the polyisopropylacrylamide solution, stirring until the solution is transparent, preserving heat and defoaming, and adding the emulsion C to prepare a second matrix;

4) preparing a gel:

heating the second matrix, adding the base solution, adding propylene glycol, slowly cooling, stirring, freezing at low temperature, thawing for 3-5 times, repeatedly filtering during thawing, and adding the first matrix to obtain gel.

In the technical scheme, in the preparation process of the base solution, the flavonoid glycoside is combined with the polypeptide to promote the absorption of skin on the flavonoid glycoside, improve the retention time of the flavonoid glycoside on the skin, continuously absorb red light, improve the anti-aging capability of gel, achieve the long-acting skin care effect, modify phycocyanin by utilizing trehalose, improve the stability of the phycocyanin, increase the moisturizing capability of the gel, prevent skin grease from being oxidized, remove free radicals on the surface of the skin, achieve the anti-aging purpose, grind polyquaternium salt solution, vitamin C ethyl ether solution, lipoic acid alcohol solution and organic silicon, refine the structure and be more beneficial to the absorption of the skin on the solution;

in the preparation process of the second matrix, the cyclodextrin is modified by utilizing the fullerene, so that the cyclodextrin is connected or included, the specific surface area of the cyclodextrin is increased, subsequent idebenone wrapping is facilitated, meanwhile, the attraction of the cyclodextrin to free radicals is improved, the anti-oxidation effect is achieved, then the idebenone is wrapped by the modified cyclodextrin, the irritation of the idebenone to the skin is reduced, the gel bacteriostasis capacity is improved, stearic acid is taken as solid fat, squalane is taken as liquid fat, lecithin and laureth-7 are taken as emulsifying agents, the inclusion compound A is emulsified to form a small molecular structure, the permeability of the idebenone and the cyclodextrin on the skin is improved, the gel stability is improved, the absorption and utilization of the skin to components are promoted while the performances of the components are ensured, and the absorption effect is optimized;

in the preparation process of the gel, the propylene glycol volatilizes in the thawing process, so that a porous structure is formed in the mixing and forming stage of the second matrix and the base liquid, the attaching degree and the air permeability between the gel and the skin are improved, meanwhile, the residual propylene glycol can dissolve dirt in the skin, the permeation of other components in the gel is promoted, the bioavailability is improved, and finally, the propylene glycol is mixed with the first matrix to prepare the finished product gel.

As a preferred embodiment of the present invention, the filtration in the step 4) is a microfiltration membrane filtration.

Compared with the prior art, the invention has the following beneficial effects:

1. according to the antioxidant and anti-aging whitening gel and the preparation method thereof, the second matrix wraps the base liquid, the first matrix wraps the second matrix and enters the first matrix through the thermosensitive release base liquid of the second matrix, so that the effect of slowly releasing the effective components from the gel is achieved, the uniform release of the effective components is promoted, the action time of the components is prolonged, the adaptability of the skin to the gel is improved, the absorption and utilization of the gel by the skin are promoted, the addition of multiple components and the mutual promotion among the components inhibit the activity of free radicals and eliminate the free radicals, the generation of melanin is inhibited, the metabolism is promoted, the peeled melanin is eliminated, and the antioxidant, anti-aging and whitening effects of the gel are achieved.

2. According to the antioxidant and anti-aging whitening gel and the preparation method thereof, the gel matrix forms a stable frame through the preparation process of the gel matrix, so that the gel base liquid can be uniformly dispersed in the gel matrix, the stability of components in the gel base liquid is improved for the preparation of the gel base liquid, the absorption of the skin to the gel base liquid is promoted, the absorption effect is optimized, the utilization rate is improved, the operation effect of each process is improved by setting the process parameters, the effect of each process on a mask is accurately mastered, and the effect of the components in the gel on the skin is improved.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Dissolving 0.5 part of polyflavonoid glycoside in pure water, adding 0.5 part of polypeptide, and performing electrophoresis to obtain polypeptide particles; dissolving 0.2 part of phycocyanin and 0.1 part of trehalose in a buffer solution, heating to 90 ℃ in a water bath, preserving heat for 24 hours, and then cooling to room temperature to obtain modified phycocyanin;

dissolving 0.002 part of polyquaternium in pure water to prepare a polyquaternium solution; taking 1 part of vitamin C ethyl ether, drying in vacuum, and dissolving in pure water to prepare a vitamin C ethyl ether solution; 0.05 part of lipoic acid is dissolved in absolute ethyl alcohol to prepare lipoic acid alcohol solution; grinding and mixing a polyquaternary ammonium salt solution, a vitamin C ethyl ether solution, a lipoic acid alcohol solution and organic silicon, respectively adding 0.01 part of astaxanthin and polypeptide particles, and fully stirring to prepare a base solution A;

dissolving 0.01 part of cyclodextrin in dimethyl sulfone, stirring, heating to 30 ℃, preserving heat, adding 0.01 part of fullerene for ultrasonic treatment, then performing microwave radiation, adding a reducing agent for reaction, cooling, cleaning and drying to obtain modified cyclodextrin; dissolving modified cyclodextrin in pure water, heating to 40 deg.C, keeping the temperature, stirring, slowly adding 0.01 part of idebenone, stirring for 30min, ultrasonic treating for 5min, standing at 4 deg.C for 18h, and oven drying at 40 deg.C to obtain clathrate B; adding stearic acid, 0.01 part of squalane, lecithin and the inclusion compound B into the same reaction kettle, heating and stirring at 79 ℃ to prepare a lipid solution, adding pure water and 0.1 part of laureth-7 into the lipid solution slowly, heating and stirring at 79 ℃ to prepare an aqueous solution, standing, placing the aqueous solution into a water bath at 79 ℃, stirring and carrying out ultrasonic treatment for 1min, stirring and dispersing the obtained liquid into pure water at the temperature of 2 ℃, and dehydrating to obtain emulsion C;

heating 0.1 part of ethylene glycol to 53 ℃, adding 1 part of propylene glycol and glycerol, uniformly stirring, adding 0.1 part of polydimethylsiloxane, uniformly stirring to obtain a mixed solution D, adding 0.5 part of carbomer, uniformly stirring, standing for 12 hours, adding the mixed solution D, uniformly stirring, slowly adding 0.1 part of triethanolamine, adjusting the consistency and viscosity of a matrix, and adding 1 part of pentaerythritol tetraisostearate to obtain a first matrix;

dissolving 30 parts of chitosan in a citric acid solution, fully stirring, standing for defoaming to prepare a chitosan solution, adding 30 parts of gelatin into distilled water, heating and stirring to fully dissolve the gelatin to prepare a gelatin solution, slowly adding the gelatin solution into the chitosan solution, continuously heating, and stirring until the solution is a transparent liquid; adding a glycerol solution into the chitosan/gelatin solution for blending, continuing to heat, adding the mixed solution D and the polyisopropylacrylamide solution, stirring until the solution is transparent, preserving heat and defoaming, and adding the emulsion C to prepare a second matrix;

heating the second matrix, adding the base solution, adding propylene glycol, slowly cooling, stirring, freezing at low temperature, thawing for 3 times, repeatedly filtering during thawing, and adding the first matrix to obtain gel.

Example 2

Dissolving 0.7 part of polyflavonoid glycoside in pure water, adding 1.2 parts of polypeptide, and performing electrophoresis to obtain polypeptide particles; dissolving 0.4 part of phycocyanin and 0.2 part of trehalose in a buffer solution, heating to 95 ℃ in a water bath, preserving the temperature for 30h, and then cooling to room temperature to obtain modified phycocyanin;

dissolving 0.004 part of polyquaternium in pure water to prepare a polyquaternium solution; taking 1.5 parts of vitamin C ethyl ether, drying in vacuum, and dissolving in pure water to prepare a vitamin C ethyl ether solution; dissolving 0.07 part of lipoic acid in absolute ethyl alcohol to prepare lipoic acid alcohol solution; grinding and mixing a polyquaternary ammonium salt solution, a vitamin C ethyl ether solution, a lipoic acid alcohol solution and organic silicon, respectively adding 0.02 part of astaxanthin and polypeptide particles, and fully stirring to prepare a base solution A;

dissolving 0.05 part of cyclodextrin in dimethyl sulfone, stirring, heating to 50 ℃, preserving heat, adding 0.05 part of fullerene for ultrasonic treatment, then performing microwave radiation, adding a reducing agent for reaction, cooling, cleaning and drying to obtain modified cyclodextrin; dissolving modified cyclodextrin in pure water, heating to 50 deg.C, keeping the temperature, stirring, slowly adding 0.03 part of idebenone, stirring for 45min, ultrasonic treating for 12.5min, standing at 12 deg.C for 21h, and oven drying at 45 deg.C to obtain clathrate B; adding stearic acid, 0.05 part of squalane, lecithin and the inclusion compound B into the same reaction kettle, heating and stirring at 82 ℃ to prepare a lipid solution, adding pure water and 0.3 part of laureth-7 into the lipid solution slowly, heating and stirring at 82 ℃ to prepare an aqueous solution, standing, placing in a water bath at 82 ℃, stirring and carrying out ultrasonic treatment for 3min, stirring and dispersing the obtained liquid into pure water at the temperature of 2 ℃, and dehydrating to obtain emulsion C;

heating 0.5 part of ethylene glycol to 54 ℃, adding 3 parts of propylene glycol and glycerol, uniformly stirring, adding 0.5 part of polydimethylsiloxane, uniformly stirring to obtain a mixed solution D, adding 0.7 part of carbomer, uniformly stirring, standing for 18 hours, adding the mixed solution D, uniformly stirring, slowly adding 0.6 part of triethanolamine, adjusting the consistency and viscosity of a matrix, and adding 3 parts of pentaerythritol tetraisostearate to obtain a first matrix;

dissolving 40 parts of chitosan in a citric acid solution, fully stirring, standing for defoaming to prepare a chitosan solution, adding 40 parts of gelatin into distilled water, heating and stirring to fully dissolve the gelatin to prepare a gelatin solution, slowly adding the gelatin solution into the chitosan solution, continuously heating, and stirring until the solution is a transparent liquid; adding a glycerol solution into the chitosan/gelatin solution for blending, continuing to heat, adding the mixed solution D and the polyisopropylacrylamide solution, stirring until the solution is transparent, preserving heat and defoaming, and adding the emulsion C to prepare a second matrix;

heating the second matrix, adding the base solution, adding propylene glycol, slowly cooling, stirring, freezing at low temperature, thawing again, repeating for 4 times, repeatedly filtering during thawing, and adding the first matrix to obtain gel.

Example 3

Dissolving 1 part of polyflavonoid glycoside in pure water, adding 2 parts of polypeptide, and performing electrophoresis to obtain polypeptide particles; dissolving 0.5 part of phycocyanin and 0.4 part of trehalose in a buffer solution, heating in a water bath to 100 ℃, preserving heat for 36 hours, and then cooling to room temperature to obtain modified phycocyanin;

dissolving 0.005 part of polyquaternium in pure water to prepare a polyquaternium solution; vacuum drying 2 parts of vitamin C ethyl ether, and dissolving in pure water to prepare a vitamin C ethyl ether solution; 0.1 part of lipoic acid is dissolved in absolute ethyl alcohol to prepare lipoic acid alcohol solution; grinding and mixing a polyquaternary ammonium salt solution, a vitamin C ethyl ether solution, a lipoic acid alcohol solution and organic silicon, respectively adding 0.02 part of astaxanthin and polypeptide particles, and fully stirring to prepare a base solution A;

dissolving 0.1 part of cyclodextrin in dimethyl sulfone, stirring, heating to 70 ℃, preserving heat, adding 0.1 part of fullerene for ultrasonic treatment, then performing microwave radiation, adding a reducing agent for reaction, cooling, cleaning and drying to obtain modified cyclodextrin; dissolving modified cyclodextrin in pure water, heating to 60 deg.C, keeping the temperature, stirring, slowly adding 0.05 part of idebenone, stirring for 60min, ultrasonic treating for 20min, standing at 20 deg.C for 24h, and oven drying at 50 deg.C to obtain clathrate B; adding stearic acid, 0.1 part of squalane, lecithin and the inclusion compound B into the same reaction kettle, heating and stirring at 85 ℃ to prepare a lipid solution, adding pure water and 0.5 part of laureth-7 into the lipid solution slowly, heating and stirring at 85 ℃ to prepare an aqueous solution, standing, placing the aqueous solution into a water bath at 5 ℃, stirring and carrying out ultrasonic treatment for 5min, stirring and dispersing the obtained liquid into pure water at the temperature of 3 ℃, and dehydrating to obtain emulsion C;

heating 1 part of ethylene glycol to 55 ℃, adding 5 parts of propylene glycol and glycerol, uniformly stirring, adding 1 part of polydimethylsiloxane, uniformly stirring to obtain a mixed solution D, adding 1 part of carbomer into pure water, uniformly stirring, standing for 24 hours, adding the mixed solution D, uniformly stirring, slowly adding 1 part of triethanolamine to adjust the consistency and viscosity of a matrix, and adding 5 parts of pentaerythritol tetraisostearate to obtain a first matrix;

dissolving 50 parts of chitosan in a citric acid solution, fully stirring, standing for defoaming to prepare a chitosan solution, adding 50 parts of gelatin into distilled water, heating and stirring to fully dissolve the gelatin to prepare a gelatin solution, slowly adding the gelatin solution into the chitosan solution, continuously heating, and stirring until the solution is a transparent liquid; adding a glycerol solution into the chitosan/gelatin solution for blending, continuing to heat, adding the mixed solution D and the polyisopropylacrylamide solution, stirring until the solution is transparent, preserving heat and defoaming, and adding the emulsion C to prepare a second matrix;

heating the second matrix, adding the base solution, adding propylene glycol, slowly cooling, stirring, freezing at low temperature, thawing again, repeating for 5 times, filtering repeatedly during thawing, and adding the first matrix to obtain the base solution.

Comparative example

The addition step of removing the polyquaternium and the methylsilanol mannuronate in the preparation method is not changed, and other steps are not changed.

Experiment:

the whitening gel and the common gel obtained in examples 1 to 3 and the comparative example were respectively tested for anti-aging and whitening ability, and the test results were recorded to obtain the following data:

selecting 60 healthy volunteers aged 30-50 years, having certain facial and eye fine lines or looseness and pigmentation, no skin sensitivity or skin damage, medical cosmetology and other problems, dividing into five groups, wherein each group of 12 persons respectively tests the gel samples prepared in examples 1-3, the gel samples prepared in comparative examples and the conventional gel on the market, continuously uses the gel samples for ten weeks and three times per week, and after the skin state of the volunteers is stable, the skin detectors such as a moisture tester and a skin moisture loss instrument are respectively used for testing the moisture content of the skin cuticle, the moisture loss of the skin, the wrinkle and texture value of the skin and the skin chromaticity at the cheeks of the volunteers after the initial period and the ten weeks, and the average value of the data of each group of volunteers is obtained by testing:

from the data in the table above, it is clear that the following conclusions can be drawn:

the examples 1 to 3 are compared with a comparative example and a common gel, and the detection results show that the water content of the skin cuticle, the water loss of the skin on the skin, the wrinkle and texture value and the skin chromaticity of the volunteers before and after the application of the gel in the examples 1 to 3 are obviously changed, the detection numerical value in the comparative example is smaller than that in the examples 1 to 3, and the detection numerical value in the common gel is smaller than that in the comparative example, which fully shows that the antioxidation, the anti-aging and whitening functions of the gel are realized, and the arrangement of the polyquaternium and the methylsilanol mannuronate can obviously improve the bioavailability of the gel, and has the advantages of excellent effect, stable effect and higher practicability.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims

1. An antioxidant and anti-aging whitening gel is characterized in that: the whitening gel comprises a first matrix, a second matrix and a base liquid, wherein the first matrix comprises the following components in parts by mass: 6-10 parts of glycerol, 0.5-1 part of carbomer, 0.1-1 part of triethanolamine and 0.1-1 part of polydimethylsiloxane, wherein the second matrix comprises the following components in parts by mass: 30-50 parts of chitosan, 30-50 parts of gelatin and 1-10 parts of poly (isopropyl acrylamide), wherein the base solution comprises the following components in parts by mass: 0.01-0.1 part of squalane, 0.01-0.05 part of idebenone, 0.01-0.1 part of cyclodextrin, 0.01-0.1 part of fullerene, 0.5-1 part of polyflavonoside, 0.5-2 parts of polypeptide, 0.2-0.5 part of phycocyanin, 0.1-0.4 part of trehalose, 0.5-1 part of organic silicon and 0.002-0.005 part of polyquaternary ammonium salt.

2. The antioxidant anti-aging whitening gel according to claim 1, characterized in that: the first matrix also comprises the following mass components: 1-5 parts of propylene glycol, 1-5 parts of pentaerythritol tetraisostearate and 0.1-1 part of octyl glycol, wherein the propylene glycol is 1, 3-propylene glycol.

3. The antioxidant anti-aging whitening gel according to claim 1, characterized in that: the base fluid also comprises the following components in parts by mass: 0.05-0.1 part of lipoic acid, 0.1-0.5 part of laureth-7, 1-2 parts of vitamin C ethyl ether and 0.01-0.02 part of astaxanthin.

4. The antioxidant anti-aging whitening gel according to claim 1, characterized in that: the polyquaternium is one or more of polyquaternium-10 and polyquaternium-7, and the organic silicon is methylsilanol mannuronate.

5. The antioxidant anti-aging whitening gel according to claim 1, characterized in that: the polypeptide is one or more of glutathione, pentapeptide, hexapeptide and nonapeptide-1.

6. The antioxidant anti-aging whitening gel according to claim 1, characterized in that: the molecular weight of the polydimethylsiloxane is 100-500.

7. The preparation method of the antioxidant anti-aging whitening gel is characterized by comprising the following steps:

1) preparing a base solution;

2) preparing a first matrix;

3) preparing a second matrix;

4) a gel was prepared.

8. The preparation method of the whitening gel with antioxidant and anti-aging effects according to claim 7, characterized by comprising the following steps:

1) preparing a base liquid:

a) synthesizing a base solution;

b) preparing an emulsion;

2) preparing a first matrix;

3) preparing a second matrix:

a) preparing a second matrix precursor;

b) synthesizing a second matrix;

4) a gel was prepared.

9. The preparation method of the whitening gel with antioxidant and anti-aging effects according to claim 8, characterized by comprising the following steps:

1) preparing a base liquid:

a) synthesizing a base solution:

b) preparing an emulsion:

2) preparing a first matrix:

3) preparing a second matrix:

a) preparing a second matrix precursor:

b) synthesizing a second matrix:

4) preparing a gel:

10. The preparation method of the whitening gel with antioxidant and anti-aging effects according to claim 9, characterized in that: the filtration in the step 4) is microporous membrane filtration.