CN110496069A - A kind of poly- peptide stoste of small molecule and preparation method thereof - Google Patents
A kind of poly- peptide stoste of small molecule and preparation method thereof Download PDFInfo
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- CN110496069A CN110496069A CN201910486485.2A CN201910486485A CN110496069A CN 110496069 A CN110496069 A CN 110496069A CN 201910486485 A CN201910486485 A CN 201910486485A CN 110496069 A CN110496069 A CN 110496069A
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- China
- Prior art keywords
- skin
- poly
- small molecule
- peptide
- stoste
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 45
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 29
- 150000003384 small molecules Chemical class 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 21
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 20
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 13
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 13
- 102000008186 Collagen Human genes 0.000 claims abstract description 12
- 108010035532 Collagen Proteins 0.000 claims abstract description 12
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 12
- 229920001436 collagen Polymers 0.000 claims abstract description 12
- 229920002643 polyglutamic acid Polymers 0.000 claims abstract description 12
- 229930003779 Vitamin B12 Natural products 0.000 claims abstract description 7
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 7
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 7
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 27
- 230000003796 beauty Effects 0.000 abstract description 7
- 208000028990 Skin injury Diseases 0.000 abstract description 5
- 239000010408 film Substances 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 5
- 239000010409 thin film Substances 0.000 abstract description 5
- 230000029142 excretion Effects 0.000 abstract description 3
- 230000009759 skin aging Effects 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 59
- 239000002537 cosmetic Substances 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 229920002545 silicone oil Polymers 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000004909 Moisturizer Substances 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000003513 alkali Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 230000001333 moisturizer Effects 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 238000006386 neutralization reaction Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 238000005461 lubrication Methods 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 210000004761 scalp Anatomy 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 201000004384 Alopecia Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000505673 Scintilla Species 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- -1 dimethyl siloxane Chemical class 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 230000003699 hair surface Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000036559 skin health Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010056474 Erythrosis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of poly- peptide stoste of small molecule, is made of the component for including following parts by weight: Sodium Hyaluronate 16-36, hyaluronic acid 8-28, vitamin B12 0.5-5, silk peptide powder 2-15, Hydrolyzed Collagen 2-14, polyglutamic acid 2-13, Cer NP 0.5-5.Invention additionally discloses the preparation methods of the poly- peptide stoste of the small molecule.The present invention is with following prominent effect: with the crease-resistant health-care effect of excellent beauty, moistening effect is good, can promote the supply of skin-nourishing and the excretion of waste, to prevent skin aging, plays beauty and face-nursing function；The reparation of skin injury and prevention effect；With excellent lubricity and film forming, after being applied to skin, thin film can be formed in skin surface, so that skin is generated good smooth feeling and moist feeling, play a protective role to skin.
Description
Technical field
The present invention relates to cosmetic field, specially a kind of poly- peptide stoste of small molecule and preparation method thereof.
Background technique
Relatively single high concentration skin care ingredient is added in stoste, can be needed for various skin, more direct to skin,
Safer, more potent maintenance allows skin to restore the beauty product of optimum state in a short time.Why stoste can become shield
Skin new trend is primarily due to stoste and possesses uniqueness not available for other skin care item.The uniqueness of exactly stoste makes it
From skin domestic demand, skin question classification, change of the energy band to skin from inside to outside are attacked directly.
Although existing stoste has relative good effect, skin particular problem is solved.It is single but there is also nursing efficacies,
Application range is narrow, is unable to satisfy in reality that but demand widely requires.
Summary of the invention
The purpose of the present invention provides a kind of poly- peptide stoste of small molecule for deficiency present in prior art described above.
It is a further object of the present invention to provide described a kind of poly- peptide stostes of small molecule and preparation method thereof.
In order to achieve the above objectives, the present invention is implemented as follows: a kind of poly- peptide stoste of small molecule, by following parts by weight
Component is made:
Preferably, the poly- peptide stoste of the small molecule is made of the component for including following parts by weight:
The steps included are as follows for the preparation method of the poly- peptide stoste of small molecule: heating water to 40-50 DEG C, then will
Sodium Hyaluronate, hyaluronic acid, vitamin B12, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid, Cer NP are added thereto,
Then it stirs evenly.
The silk peptide factor (silk peptide powder) that the poly- peptide stoste of small molecule of the present invention contains can after penetrating epidermis and reaching basal layer
As the signal factor in conjunction with the cell surface recipient of wounded tissue, stimulate the cell at the position to generate a large amount of collagen egg
It is white, however the substance of the microorganisms such as hyaluronic acid elastomer prepared in scintilla makes the tissue of injury, replys tightly
In fact fill out the effect of punching, and allow cytothesis the effect of.The poly- peptide stoste of small molecule of the present invention is to human body and environmental nonpollution, nontoxic
It is harmless can biodegrade, the solution of water-soluble, the available tasteless clean transparent of Eco-friendly is formed, after being easily cross-linked to form
Phase possesses the hydrogel of excellent performance, is a kind of water-solube and biodegradable, without toxic.The poly- peptide stoste of small molecule of the present invention is not
It is siliceous, it can be used in shampoo and hair conditioner, the silicone oil and cationic wash clean on hair can be will stay on, thus discount
State of the hair in zero silicone oil or few silicone oil deposition, has very great help for the health of scalp and hair quality.Hair washing
Hair products contain silicon, can make one alopecia, hair loss, scalp itch, although hair wash after be along smooth cunning, be because washing
The chemical constituents such as silicon or dimethyl siloxane are added in shampoo, the effect of the component is that the gap between hair scale piece is filled out
It is full, smooth tactile, but the impermeability of silicon itself and other inertia are then caused, pore can be also closed, scalp is caused also to hold
It easily itches, in some instances it may even be possible to concurrently shave one's head, the sequelae of alopecia.
Generally speaking, compared with prior art, the present invention is with following prominent effect: with the crease-resistant guarantor of excellent beauty
Strong effect, moistening effect is good, can promote the supply of skin-nourishing and the excretion of waste, to prevent skin aging, plays beauty
Appearance and face-nursing function；Reparation and prevention effect with skin injury；With good lubricity and film forming, it is applied to skin
Afterwards, thin film can be formed in skin surface, so that skin is generated good smooth feeling and moist feeling, protection is played to skin and is made
With；It is used as treatment, thin film can be formed in hair surface, played moisturizing, lubrication, hair care, eliminate the effects of electrostatic,
Hair is set to be easy to comb, elegant nature；Enhance the resistance of skin, antibacterial, antiallergy；It is deposited on hair and on skin in the past
Fragrant molecule, be broken compound key under the action of oxygen, release volatility perfume (or spice) molecule, but the silk peptide in the poly- peptide stoste of small molecule
Powder can bind more fragrant molecular breakdown compound keys, play the effect of sustained release, increase the time that essence molecule retains, and extend fragrant
The rear perfume (or spice) of essence, reduces the usage amount of essence；Be mainly used for cosmetic industry, such as hair-washing hair-care, scald dye, shower, face cleaning, cream,
The fields such as essential oil, skin care item foot care product.
Specific embodiment
The present invention is further illustrated combined with specific embodiments below, it should be noted that embodiment is not constituted
Limitation to the claimed scope of the invention.
The poly- peptide stoste of small molecule of the present invention is to utilize Sodium Hyaluronate, hyaluronic acid, vitamin B12, silk peptide powder, hydrolysis
Collagen, polyglutamic acid, Cer NP compound to obtain living cells stoste.Be mainly used for cosmetic industry, such as hair-washing hair-care,
Scald the fields such as dye, shower, face cleaning, cream, essential oil, skin care item foot care product.With excellent buffer capacity, acid can be effectively balanced
Base number, reducing rouge accumulation, effectively scintilla combines (such as silicon, rouge, alcohol, fat, ammonia, sulphur, acid) with the composition in product simultaneously
The respective function of antioxidant punching point expansion is formed, can also avoid being destroyed in process of production.The silk peptide wherein contained
The factor can be used as the signal factor in conjunction with the cell surface recipient of wounded tissue, stimulation after penetrating epidermis and reaching basal layer
The a large amount of Hydrolyzed Collagen of cell generation at the position, however the microorganisms such as hyaluronic acid elastomer prepared in scintilla
Substance make the tissue of injury, reply consolidation and fill out the effect of punching.And allow cytothesis the effect of.To human body and environment
It is pollution-free, nontoxic can biodegrade, form the solution of water-soluble, the available tasteless clean transparent of Eco-friendly,
It is easily cross-linked to form the hydrogel that the later period possesses excellent performance, is a kind of water-solube and biodegradable, without toxic, molecular weight is from 1
The transparent stoste of ten thousand to 200 ten thousand dalton.It is not siliceous, it can be used in shampoo and hair conditioner, can will stay on hair
Silicone oil and cationic wash clean, to allow hair be in the state that zero silicone oil or few silicone oil deposit, for scalp and hair
The health of matter has very great help.
The poly- peptide stoste specific embodiment of small molecule of the present invention is as shown in the table:
The steps included are as follows for the preparation method of the poly- peptide stoste of small molecule: 40-50 DEG C is heated water to, it then will be saturating
Bright matter acid sodium, hyaluronic acid, vitamin B12, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid, Cer NP are added thereto, so
After stir evenly.Preferably, heating temperature is 44 DEG C.
Wherein, the molecular weight of the Sodium Hyaluronate and hyaluronic acid is 10000, and the molecular weight of polyglutamic acid is
700000.Silk peptide powder also referred to as hydrolyzes silk fibroin powder, can be dissolved in water, be the natural polymer subbundle egg extracted from silk
White, content accounts for about the 70%~80% of silk, contains 18 kinds of amino acid, wherein glycine (gly), alanine (ala) and silk ammonia
Sour (ser) accounts for about 80% of total composition or more.Solvent can be water or the organic solvent for being dissolved in water, such as alcoholic solvent.
Through detecting, the poly- peptide former liquid product physical and chemical index of small molecule is as follows:
| Appearance | Micro- Huang transparency liquid |
| Smell | Characteristic odor, it is odorless |
| pH | 5.5-7.5 |
| Index of refraction | 1.400-1.500 |
| Specific gravity (20%) | 0.980-1.100 |
| Content of beary metal | ≤20ppm |
| Arsenic content (As) | ≤2ppm |
| Preservative | It is not added with |
| Total number of bacteria | Leethan100cfu/g |
| Escherichia coli | It must not detect |
Through experimental tests, the poly- peptide stoste of small molecule of the present invention have following superiority for skin nursing:
1, wrinkle resistance
Sodium Hyaluronate, hyaluronic acid, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid, neural acyl in the application formula
The compounding of amine 3 is synergistic, has very good wrinkle resistance.Because in the wet horizontal and poly- peptide stoste of small molecule of skin thoroughly
Bright matter acid content is closely related, and with advancing age, hyaluronic acid contents decline in skin, makes skin moisturizing miopragia,
Generate wrinkle.Aqueous solution of sodium hyaluronate has stronger viscoelasticity and lubricity, is applied to skin surface, can form one layer of moisturizing
Ventilated membrane keeps skin moisturizing glossy.Hyaluronic acid can penetrate into skin corium, promote blood microcirculation, be conducive to skin to battalion
The absorption for supporting substance, plays the crease-resistant health-care effect of beauty.
2, moisture-keeping function
Sodium Hyaluronate, hyaluronic acid, silk peptide powder in the application formula, Hydrolyzed Collagen, polyglutamic acid collaboration increase
Effect has good moisture retention.Sodium Hyaluronate and the polyglutamic acid most important effect in cosmetics in the poly- peptide stoste of small molecule,
Compared with other moisturizer, influence of the relative humidity of ambient enviroment to its moisture retention is smaller.The common moisturizer of cosmetics has
Glycerol, propylene glycol, sorbierite, polyethylene glycol, sodium lactate, pyrrolidone sodium carboxylate etc..Experiment shows and these moisturizer phases
Than, hygroscopic capacity highest of the Sodium Hyaluronate under low relative humidity (33%), and the hygroscopic capacity under high relative humidity (75%)
It is minimum.This unique property, positive adaptation skin is under Various Seasonal, varying environment humidity, such as dry winter and humidity
Summer, the requirement to cosmetics moisture-keeping function.The moisture retention of Sodium Hyaluronate is related with its quality, and quality is higher, performance of keeping humidity
Better.Sodium Hyaluronate is often used cooperatively with other moisturizer as the less exclusive use of moisturizer.Pass through CM825 type skin
Moisture tester and skin patch test, the results showed that the poly- peptide stoste moistening effect of the small molecule that the present invention obtains is excellent, tested
Person smear skin moisture content after the tested material 2 and 4h change rate be respectively (103.9 ± 0.2) % and (112.2 ±
0.2) %；Skin patch test the result shows that the poly- peptide stoste of small molecule to skin safe, nonirritant.
3, trophism
Vitamin B12, silk peptide powder, Hydrolyzed Collagen in the application formula have excellent trophism.Hyalomitome
Sour sodium is the intrinsic biological substance of skin, and exogenous Sodium Hyaluronate is the supplement to skin endogenous hyaluronic acid sodium.Matter
Skin epidermis can be penetrated by measuring lesser Sodium Hyaluronate, promote the supply of skin-nourishing and the excretion of waste, to prevent skin
Skin aging, plays beauty and face-nursing function.
4, the reparation of skin injury and prevention effect
Vitamin B12, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid, Cer NP in the application formula have good
The reparation of good skin injury and prevention effect.Skin burnt by light caused by solar exposure or day toast, as erythrosis,
Blackening, decortication etc., the mainly effect of the ultraviolet light in sunlight.Sodium Hyaluronate is by promoting epidermis in the poly- peptide stoste of small molecule
The proliferation of cell and differentiation and the effect of scavenging activated oxygen, can promote the regeneration of injury skin, and use also has in advance
Certain prevention effect.Its mechanism of action is different from ultraviolet absorbing agent common in suncream, therefore, the ha in sunlight screening skin-protecting product
It is used in mixed way with ultraviolet absorbing agent, there is synergistic effect, the transmission of ultraviolet light can be reduced simultaneously and to a small amount of ultraviolet of transmission
Skin injury caused by line is repaired, and the regeneration of epidermal cell can be accelerated by playing double protection, makes skin delicacy light
It is sliding, high resilience.When skin is by slight burn and scald, the aqua cosmetics containing Sodium Hyaluronate are smeared on surface can reduce pain
Bitterly, accelerate the healing of injury skin.
5, lubricity and film forming
Sodium Hyaluronate, hyaluronic acid, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid, neural acyl in inventive formulation
Amine 3 has good lubricity and film forming.Sodium Hyaluronate belongs to high molecular polymer in the poly- peptide stoste of small molecule, has very strong
Lubrication sense and film forming.Lubrication sense is obvious when skin care item containing Sodium Hyaluronate are smeared, and feel is good.It, can after being applied to skin
Thin film is formed in skin surface, so that skin is generated good smooth feeling and moist feeling, plays a protective role to skin.Contain
The treatment of Sodium Hyaluronate can form thin film in hair surface, play moisturizing, lubrication, hair care, elimination electrostatic etc. and make
With, make hair be easy to comb, elegant nature.
6, the pH value for maintaining skin health, enhances the resistance of skin, antibacterial, antiallergy.
Polyglutamic acid in the recipe ingredient of this Shen has extremely strong alkali neutralization ability to skin, can stablize the pH of skin
Value, different people often changes between 4.5~6.5 in the pH value of different times skin, goes beyond the scope there are also super,
If skin ph is for a long time except 5.0~5.6, the alkali neutralization ability of skin will weaken, and skin quality will change, and finally lead
Cause the aging and damage of skin.So only match corresponding skin care item, make skin ph be maintained at pH5.0~5.6 it
Between, optimum state can be just presented in skin, be really achieved more beautiful, healthier effect.Any skin care mode, cannot all violate
This principle.The alkali neutralization ability of visible dermis is the key that skin health.Regardless of skin surface pH-value is how many, as long as
Its " alkali neutralization ability " is prosperous and powerful, can resist the anaphylactogen for be easy to causeing allergy, skin is made to keep fit.If " alkali neutralization energy
Power " is weaker, even if the pH value measured is very low, also can be easy allergy because not neutralizing alkaline stimulation.Also it is easy for by the external world
It learns the injury of stimulation and corresponding skin lesion occurs, such as flush, inflammation and various fash.In addition, the weak acid ring of skin surface
Border can also inhibit the growth of certain pathogenic microorganisms, it is made not come to harm.
7, enable essence class raw material preferably lasting lasting.
It is deposited on the fragrant molecule on hair and on skin in the past, is broken compound key under the action of oxygen, releases volatilization
Property perfume (or spice) molecule, but the silk peptide powder in the poly- peptide stoste of small molecule can bind more fragrant molecular breakdown compound keys, play sustained release
Effect increases the time that essence molecule retains, extends the rear perfume (or spice) of essence, reduce the usage amount of essence.
As described above, only presently preferred embodiments of the present invention, when cannot be limited the scope of implementation of the present invention with this,
I.e. generally according to simple equivalent changes and modifications made by scope of the present invention patent and invention description content, all still belong to the present invention
In the range of patent covers.
Claims (3)
1. a kind of poly- peptide stoste of small molecule, which is characterized in that be made of the component for including following parts by weight:
2. the poly- peptide stoste of a kind of small molecule according to claim 1, which is characterized in that by the group including following parts by weight
Divide and be made:
3. a kind of preparation method of the poly- peptide stoste of small molecule according to claim 1 or 2, which is characterized in that by water plus
Heat to 40-50 DEG C, then by Sodium Hyaluronate, hyaluronic acid, vitamin B12, silk peptide powder, Hydrolyzed Collagen, polyglutamic acid,
Ceramide is added thereto, and is then stirred evenly.
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| CN115501139A (en) * | 2022-09-29 | 2022-12-23 | 李克明 | Lecithin and preparation method thereof |
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Application publication date: 20191126 |