CN109498481A

CN109498481A - A kind of antisenility skin care hydrogel mask matrix and preparation method thereof

Info

Publication number: CN109498481A
Application number: CN201811512616.1A
Authority: CN
Inventors: 刘昊; 窦楠楠
Original assignee: Beijing Beauty Cosmetics Co Ltd
Current assignee: Beijing Beauty Cosmetics Co Ltd
Priority date: 2018-12-11
Filing date: 2018-12-11
Publication date: 2019-03-22

Abstract

The invention discloses a kind of containing there are many antisenility skin care hydrogel mask matrixes of natural extract and biologically active polypeptide and preparation method thereof.The characteristics of present invention is combined using compatibility in Chinese traditional herbs, by moisturizer and biologically active polypeptide and a variety of natural extracts according to usage ratio appropriate in conjunction with form hydrogel mask matrix, give full play to the good water lock of hydrogel and adhesion, make the nutritional ingredient slow release in facial mask and is effectively absorbed and reduced by skin allergy, moisturizing moisturizing, it is anti-inflammatory, the multiple functions such as anti-oxidant and reparation skin combine, improving skin-nourishing metabolism, it keeps repairing epidermal tissue while elasticity of skin, to reach moisturizing and crease-resistant and anti-aging multi-efficiency.

Description

A kind of antisenility skin care hydrogel mask matrix and preparation method thereof

Technical field

The present invention relates to daily cosmetics technical fields, and in particular to one kind is containing there are many natural extract and bioactivity Antisenility skin care hydrogel mask matrix of polypeptide and preparation method thereof.

Background technique

The skin aging of people is caused by natural cause or non-natural factor, and the growth stage of skin histology generally ends at 25 years old Left and right, hereafter growth carries out simultaneously with aging, and Elastic fibers are gradually thicker, slowly with age sustainable growth skin aging Obviously.Skin aging is usually embodied in skin elasticity, wrinkle of skin and roughness, moistens the several respects such as intensity, in addition environment, sun The factors such as light and pressure can make free radical injury skin, and skin ageing is promoted to accelerate, so that skin is easy to appear spot, microgroove etc. Phenomenon using moisturizer skin care is clearly merely inadequate for prevention skin aging in daily life.

Facial mask is temporarily isolating outside air and pollution as a kind of skin care item, using the time for being covered in face, improves The temperature of skin, expands skin pore, promotes sweat gland secretion and metabolism, increase the oxygen content of skin, be conducive to flesh Skin excludes the product of epidermal cell metabolism and the oil substances of accumulation, and the moisture in facial mask can also penetrate into epidermal cell Cuticula, makes skin become soft, and active constituent is added in facial mask can then assign its better skin-protecting function.

Hydrogel facial mask solves the disadvantage that traditional sticking type facial mask exists.Hydrogel is by polymer three-dimensional cross-linked network The multicomponent system that structure and filling solvent collectively constitute.After hydrogel has the moisture that can be absorbed higher than sole mass hundreds of times It keeps gel state and is not dissolved in water, there is good water lock.In addition, can be good at simulating after hydrogel water absorption and swelling Tissue, have certain flexibility and viscoplasticity, can perfection be attached to skin surface.

With the understanding to ingredient in natural extract and effect, people start with what compatibility in Chinese traditional herbs combined Feature carrys out development function more comprehensively and effectively cosmetics.For example, by moisturizer and Several Active Peptides and natural extract In conjunction with hydrogel facial mask is formed, to reach moisturizing and crease-resistant and anti-aging combination, and improve the current single moisturizing of facial mask A kind of approach of protection.In addition, the compatibility of the additive capacity of each active component and a variety of natural extracts in cosmetic formulations Property be also realize good effects an important factor for.

Summary of the invention

In view of further appreciating that at present to ingredient in natural extract and effect, the present invention utilizes to be matched in Chinese traditional herbs 5 combination the characteristics of by moisturizer with biologically active polypeptide and a variety of natural extracts in conjunction with, thus realize cosmetics moisturizing and The multi-efficiencies such as crease-resistant and anti-aging.

The present invention one is designed to provide a kind of antisenility skin care hydrogel composition, and the composition includes naturally to mention Object, polypeptide, anti-inflammatory agent and moisturizer are taken, wherein the natural extract is for three kinds below, four kinds or all: tremella (Tremella fuciformis) polysaccharide, grape (Vitis vinifera) seed extract, centella (Centella Asiatica) extract, hamamelis (Hamamelis virginiana) extract and dendrobium candidum (Dendrobium Candidum) extract, the polypeptide are as follows: collagen, palmityl tripeptides -1 and palmityl tetrapeptide -7, the anti-inflammatory agent are as follows: Radix Glycyrrhizae Sour dipotassium and allantoin, the moisturizer are as follows: polyglutamic acid, Sodium Hyaluronate and tetrahydro methylpyrimidine carboxylic acid；And

The composition further includes chelating agent, dispersing agent, emulsifier, thickener, preservative, buffer and solvent, wherein The chelating agent is EDETATE SODIUM, and the dispersing agent is glycerol, and the emulsifier is polysorbate -20, and the thickener is Chondrus crispus (Chondrus crispus) powder, algaroba (Ceratonia siliqua) glue, hydroxyethyl cellulose and Ka Bo Nurse, the preservative are methyl hydroxybenzoate, Phenoxyethanol and Chlorphenesin, and the buffer is potassium chloride, and the solvent is water, third Two pure and mild butanediols.

A variety of skin care activity ingredients used in the present invention are current medical, health care and beauty industry is widely applied has Imitate ingredient, especially wherein Small side effects, poison the hot spot that small Chinese traditional herbs extract is even more current application, specifically, Such as:

Tremella polysaccharides are a kind of acid heteroglycans, have xylose, mannose, fucose, glucose in its composition after hydrolysis With glucuronic acid etc..Tremella polysaccharides are Basidiomycetes polysaccharide para-immunity reinforcing agent, and having improves body's immunity and promoted white The effect of cell；Tremella polysaccharides can also promote protein and nucleic acid to synthesize, and increase the repair ability of itself, safeguard each organ group The function of especially liver is knitted, there is delaying senility function.

Grape seed extract is that isolated polyphenols is extracted from grape pip, is the plant origin found so far One of most efficient antioxidant, mainly by procyanidine, catechin, epicatechin, gallic acid, epicatechin gallate The polyphenols such as ester composition.Its procyanidins is a kind of new and effective antioxidant, be find so far it is most potent Free radical scavenger, have a very strong activity in vivo, and absorb complete rapidly；Procyanidine can also reduce heart disease, cancer The initiation potential of disease, early ageing and arthritis etc. has enhancing skin elasticity and smoothness, radiation of the prevention sunray to skin Damage and other effects.

Gotu Kola P.E main component is asiaticosid, madecassoside, and wherein asiaticosid is to scar fibroblast Cell viability has facilitation, so scar of dispelling, fine with phospholipid material polymerization effect, has to elimination whelk brighter Aobvious effect.Gotu Kola P.E can promote collagen in skin corium to be formed, and have the effect for enabling that skin is compact, soft, It can also promote blood circulation, improve acne skin, and prevent pigementation.

Hamamelis extract contains polyphenols and various plants tannin, and main component has tannic acid, galla turcica Acid, catechin, procyanidine, Protoapigenone (Kaempferol, Quercetin), essential oil (carvacrol, eugenol, hexenol), choline and Saponin；It releives with anti-oxidant, anti-inflammatory, anti-anaphylaxis and astriction；Skin cell metabolism can be enhanced and maintain skin elasticity With it is crease-resistant, there are also good moisture holding capacity.

Dendrobium candidum is China's tradition enriching yin rare Chinese medicine, extract main pharmacodynamics ingredient be dendrobium polysaccharide, alkaloid, Glucosides, luxuriant and rich with fragrance class, bibenzyl and amino acid etc., wherein the highest dendrobium polysaccharide of content have anticancer, it is anti-inflammatory, antiviral, hypoglycemic, The effect of repairing itself and improving immunity and moisturizing, increase skin elasticity, improve the colour of skin and enhancing skin barrier.

Collagen (Collagen) is also known as collagen, is the spirality fiber shape protein twisted by three peptide chains.Collagen Growth, aging and the disease of albumen and body have it is extremely close contact, because it is with good biocompatibility, nutrition Property, prosthetic, moisture retention, compatibility and compatibility, so being widely used in biomedical material, cosmetics, food and guarantor The functional products such as strong product.

Dipotassium glycyrrhizinate has the multiple efficacies such as antibacterial, anti-inflammatory, removing toxic substances, antiallergic, deodorization.Dipotassium glycyrrhizinate can activate cortex Steroid and enhance its effect indirectly, for cosmetics can in and/or lower the noxious material in cosmetics to prevent Allergic reaction has extensive compatibility in cosmetics, often shares with other activating agents, can accelerate absorption of the skin to them And synergy.

Allantoin (allantoin) is a kind of hydantoin derivatives, has and promotes cell growth, accelerates wound and is cured It closes, the physiological functions such as cutin-softening albumen are the good consolidant and antiulcer agents of skin trauma.Since allantoin is a kind of Amphoteric compound, can in conjunction with many kinds of substance formed double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, skin can be made Moisture content, moist and softness are kept, is the good additive of the cosmetics such as beauty, hairdressing.

Palmityl tripeptides -1 can promote skin collagen to generate, and keep face skin full and assign elasticity, improve flesh Skin water content and water lock moisturizing degree keep skin feel soft and moist satiny.

Palmityl tetrapeptide -7 is can to delay and inhibit excessive cell interleukin by the synthetic peptide of four Amino acid profiles Generation, thus inhibit some inappropriate inflammatory reactions and glycosylation damage.

Tetrahydro methylpyrimidine carboxylic acid (ectoin) is that be widely present in Halophiles and streptomyces and Escherichia coli etc. non- Osmoprotecting substances in Halophiles.Tetrahydro methylpyrimidine carboxylic acid is a kind of immunomodulator of skin, can stablize cell egg The structure of white matter reduces the injury because of dry and ultraviolet light Irradiation on Skin, with good moisturizing, maintenance, anti-microgroove function Effect.

In some embodiments of the above-mentioned antisenility skin care hydrogel composition of the present invention, based on described in 100 parts by weight It includes each components with following parts by weight for hydrogel composition: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape pips extract Object, 0.01-2 part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts； 0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids； And

The composition further includes chelating agent, dispersing agent, emulsifier, thickener, preservative, buffer and solvent, wherein The chelating agent is EDETATE SODIUM, and the dispersing agent is glycerol, and the emulsifier is polysorbate -20, and the thickener is Chondrus crispus powder, algaroba glue, hydroxyethyl cellulose and carbomer, the preservative are methyl hydroxybenzoate, Phenoxyethanol and chlorine The sweet ether of benzene, the buffer are potassium chloride, and the solvent is water, propylene glycol and butanediol.

Another object of the present invention is to provide a kind of antisenility skin care hydrogel mask matrix, based on 100 parts by weight institutes Stating hydrogel mask matrix, it includes each components with following parts by weight: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape pips Extract, 0.01-2 part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts； 0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids； 0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts Algaroba glue, 0.1-2 part hydroxyethyl cellulose, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of benzene oxygen Ethyl alcohol is no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, and surplus is to go Ionized water.

In some embodiments of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight institutes Stating hydrogel mask matrix, it includes each components with following parts by weight: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape pips Extract, 0.01-2 part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-1 parts of dendrobium candidum extracts； 0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids； 0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts Algaroba glue, 0.1-2 part hydroxyethyl cellulose, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of benzene oxygen Ethyl alcohol is no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, and surplus is to go Ionized water.

In other embodiments of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight It includes each components with following parts by weight for the hydrogel mask matrix: 0.01-2 parts of tremella polysaccharides, 0.01-1 portions of grapes Seed extract, 0.01-2 part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-1 parts of dendrobium candidums extract Object；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates With 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylics Acid；0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 Part algaroba glue, 0.1-2 parts of carbomers, is no more than 0.2 part of methyl hydroxybenzoate, is no more than 1 part of benzene 0.1-2 parts of hydroxyethyl celluloses Oxyethanol, be no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are Deionized water.

In the other embodiment of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight It includes each components with following parts by weight for the hydrogel mask matrix: 0.01-2 parts of tremella polysaccharides, 0.01-2 portions of grapes Seed extract, 0.1-1 part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidums extract Object；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates With 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylics Acid；0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 Part algaroba glue, 0.1-2 parts of carbomers, is no more than 0.2 part of methyl hydroxybenzoate, is no more than 1 part of benzene 0.1-2 parts of hydroxyethyl celluloses Oxyethanol, be no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are Deionized water.

In some embodiments of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight institutes Stating hydrogel mask matrix, it includes each components with following parts by weight: 0.01-1 parts of tremella polysaccharides, 0.01-2 parts of grape pips Extract, 0.01-2 part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts； 0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids； 0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts Algaroba glue, 0.1-2 part hydroxyethyl cellulose, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of benzene oxygen Ethyl alcohol is no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, and surplus is to go Ionized water.

In other embodiments of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight It includes each components with following parts by weight for the hydrogel mask matrix: 0.01-1 parts of tremella polysaccharides, 0.01-1 portions of grapes Seed extract, 0.01-2 part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidums extract Object；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates With 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylics Acid；0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 Part algaroba glue, 0.1-2 parts of carbomers, is no more than 0.2 part of methyl hydroxybenzoate, is no more than 1 part of benzene 0.1-2 parts of hydroxyethyl celluloses Oxyethanol, be no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are Deionized water.

In the other embodiment of the above-mentioned antisenility skin care hydrogel mask matrix of the present invention, it is based on 100 parts by weight It includes each components with following parts by weight for the hydrogel mask matrix: 0.01-1 parts of tremella polysaccharides, 0.01-2 portions of grapes Seed extract, 0.01-1 part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidums extract Object；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates With 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylics Acid；0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 Part algaroba glue, 0.1-2 parts of carbomers, is no more than 0.2 part of methyl hydroxybenzoate, is no more than 1 part of benzene 0.1-2 parts of hydroxyethyl celluloses Oxyethanol, be no more than 0.3 part of Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are Deionized water.

Another object of the present invention is to provide a kind of method for preparing above-mentioned hydrogel mask matrix comprising following step It is rapid:

1) following components of corresponding parts by weight is uniformly mixing to obtain in suitable quantity of water solution A and is heated to 70 DEG C: glycerol, Propylene glycol, Chondrus crispus powder, algaroba glue, potassium chloride, hydroxyethyl cellulose, EDETATE SODIUM, allantoin, carbomer, poly- mountain Pears alcohol ester -20；

2) following components of corresponding parts by weight is dissolved in solution A under heating and uniform stirring and obtains solution B: fourth two Alcohol, collagen, polyglutamic acid, Sodium Hyaluronate, tremella polysaccharides, grape seed extract, Gotu Kola P.E, hamamelis are extracted Object, dendrobium candidum extract, dipotassium glycyrrhizinate, palmityl tripeptides -1, palmityl tetrapeptide -7 and tetrahydro methylpyrimidine carboxylic acid；

3) following components of corresponding parts by weight is added in solution B under uniform stirring and obtains solution C and is heated to 80 DEG C: methyl hydroxybenzoate, Phenoxyethanol and Chlorphenesin；

4) acquired solution C is stood and is cooled to after 75 DEG C and filtered up to the hydrogel mask matrix.

Corresponding antisenility skin care hydrogel facial mask is prepared then to need to continue following steps:

5) above-mentioned hydrogel mask matrix is maintained to 65-70 DEG C of temperature, while pouring into roll coater with flat sheet Molding, solidifies above-mentioned molding product by the cooler between temperature -10~4 DEG C, is then cut into through cutting machine The hydrogel facial mask of forming.

Beneficial effect

The characteristics of present invention is combined using compatibility in Chinese traditional herbs, by moisturizer and biologically active polypeptide and a variety of natural Extract is combined according to usage ratio appropriate, is prepared containing there are many anti-aging of natural extract and biologically active polypeptide shields Skin hydrogel mask matrix gives full play to the good water lock of hydrogel and adhesion, releases that the nutritional ingredient in facial mask slowly It puts and is effectively absorbed and reduced by skin allergy, the multiple functions such as moisturizing moisturizing, anti-inflammatory, anti-oxidant and reparation skin are combined Come, improve skin-nourishing metabolism, keep elasticity of skin while repair epidermal tissue, thus reach moisturizing with it is crease-resistant and anti-ageing Old multi-efficiency.

Specific embodiment

The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..Unless otherwise specified, embodiment Used in the conventional means that are well known to those skilled in the art of technological means.

Embodiment

Tremella (Tremella fuciformis) polysaccharide and the purchase of dendrobium candidum (Dendrobium candidum) extract From Shaanxi Sen Fu natural product Co., Ltd, grape (Vitis vinifera) seed extract is purchased from Nanjing treasure only health biotechnology Co., Ltd, centella (Centella asiatica) extract are purchased from Hunan Lang Lin living resources limited liability company, North America Witch hazel (Hamamelis virginiana) extract is purchased from Xi'an Bai Chuan Biotechnology Co., Ltd；Collagen is France Luo Sai Lip river (Rousselot) product, palmityl tripeptides -1 and palmityl tetrapeptide -7 are purchased from Nanjing Tai Ye Biotechnology Co., Ltd；Radix Glycyrrhizae Sour dipotassium is purchased from Guangzhou Yi Jin Biotechnology Co., Ltd, and allantoin is Switzerland's Clariant product；Polyglutamic acid and hyaluronic acid Sodium is purchased from Xi'an Bai Chuan Biotechnology Co., Ltd, and tetrahydro methylpyrimidine carboxylic acid is purchased from one Chemical Co., Ltd. of Guangzhou river；Ripple Irish moss (Chondrus crispus) powder, algaroba (Ceratonia siliqua) glue are that U.S. Si Bikai can (CPKelco) Product, hydroxyethyl cellulose be Dow (DOW) product.

Embodiment 1

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight, it includes tools There is each component of following parts by weight: 0.01 part of tremella polysaccharides, 1 part of grape seed extract, 2 parts of Gotu Kola P.Es, 1 part of North America gold Thread prunus mume extract and 1 part of dendrobium candidum extract；2 parts of collagens, 2 parts of palmityl tripeptides -1 and 1 part of palmityl tetrapeptide -7；2 parts sweet Oxalic acid dipotassium and 0.01 part of allantoin；1 part of polyglutamic acid, 0.01 part of Sodium Hyaluronate and 1 part of tetrahydro methylpyrimidine carboxylic acid；0.01 Part EDETATE SODIUM, 1 part of glycerol, 0.01 part of polysorbate -20,0.1 part of Chondrus crispus powder, 5 parts of algaroba glue, 1 part of hydroxyl second Base cellulose, 0.1 part of carbomer, 0.05 part of methyl hydroxybenzoate, 0.5 part of Phenoxyethanol, 0.1 part of Chlorphenesin, 0.1 part of potassium chloride, 0.5 part of propylene glycol and 0.3 part of butanediol, surplus are deionized water.

The preparation step of above-mentioned hydrogel mask matrix is as follows:

Embodiment 2

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight it includes with The component of lower parts by weight: 1 part of tremella polysaccharides, 0.01 part of grape seed extract, 2 parts of Gotu Kola P.Es, 2 parts of hamamelis mention Take object and 1 part of dendrobium candidum extract；1 part of collagen, 1 part of palmityl tripeptides -1 and 0.01 part of palmityl tetrapeptide -7；1 part of glycyrrhizic acid Dipotassium and 1 part of allantoin；0.5 part of polyglutamic acid, 0.01 part of Sodium Hyaluronate and 0.5 part of tetrahydro methylpyrimidine carboxylic acid；0.5 part EDETATE SODIUM, 2 parts of glycerol, 0.5 part of polysorbate -20,1 part of Chondrus crispus powder, 4 parts of algaroba glue, 2 parts of hydroxy ethyl fibers Element, 0.5 part of carbomer, 0.1 part of methyl hydroxybenzoate, 0.3 part of Phenoxyethanol, 0.2 part of Chlorphenesin, 1 part of potassium chloride, 1 part of propylene glycol With 1 part of butanediol, surplus is deionized water.

The step of preparing above-mentioned hydrogel mask matrix and it is further processed into corresponding antisenility skin care water-setting glue surface The step of film, is identical as described in embodiment 1.

Embodiment 3

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight it includes with The component of lower parts by weight: 2 parts of tremella polysaccharides, 2 parts of grape seed extracts, 0.1 part of Gotu Kola P.E, 1 part of hamamelis mention Take object and 1 part of dendrobium candidum extract；0.01 part of collagen, 0.01 part of palmityl tripeptides -1 and 2 parts of palmityl tetrapeptides -7；0.01 part Dipotassium glycyrrhizinate and 2 parts of allantoins；2 parts of polyglutamic acids, 2 parts of Sodium Hyaluronates and 0.01 part of tetrahydro methylpyrimidine carboxylic acid；1 part EDETATE SODIUM, 2.5 parts of glycerol, 1 part of polysorbate -20,2.5 parts of Chondrus crispus powder, 3 parts of algaroba glue, 0.1 part of ethoxy Cellulose, 1 part of carbomer, 0.2 part of methyl hydroxybenzoate, 0.4 part of Phenoxyethanol, 0.1 part of Chlorphenesin, 2 parts of potassium chloride, 2 parts the third two Pure and mild 3 parts of butanediols, surplus is deionized water.

Embodiment 4

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight it includes with The component of lower parts by weight: 1 part of tremella polysaccharides, 2 parts of grape seed extracts, 1 part of Gotu Kola P.E, 0.01 part of hamamelis mention Take object and 2 parts of dendrobium candidum extracts；1 part of collagen, 2 parts of palmityl tripeptides -1 and 1 part of palmityl tetrapeptide -7；1 part of glycyrrhizic acid two Potassium and 0.5 part of allantoin；1 part of polyglutamic acid, 1 part of Sodium Hyaluronate and 1 part of tetrahydro methylpyrimidine carboxylic acid；2 parts of EDETATE SODIUMs, 3 Part glycerol, 2 parts of polysorbate -20,3 parts of Chondrus crispus powder, 2.5 parts of algaroba glue, 1 part of hydroxyethyl cellulose, 2 parts of card waves Nurse, 0.05 part of methyl hydroxybenzoate, 1 part of Phenoxyethanol, 0.2 part of Chlorphenesin, 1 part of potassium chloride, 1.5 parts of propylene glycol and 4 parts of butanediols, Surplus is deionized water.

Embodiment 5

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight it includes with The component of lower parts by weight: 1 part of tremella polysaccharides, 1 part of grape seed extract, 2 parts of Gotu Kola P.Es, 2 parts of hamamelis are extracted Object and 0.01 part of dendrobium candidum extract；0.5 part of collagen, 2 parts of palmityl tripeptides -1 and 1 part of palmityl tetrapeptide -7；1 part of glycyrrhizic acid Dipotassium and 1 part of allantoin；1 part of polyglutamic acid, 1 part of Sodium Hyaluronate and 1 part of tetrahydro methylpyrimidine carboxylic acid；1 part of EDETATE SODIUM, 4 Part glycerol, 1 part of polysorbate -20,4 parts of Chondrus crispus powder, 1 part of algaroba glue, 0.5 part of hydroxyethyl cellulose, 1 part of card wave Nurse, 0.1 part of methyl hydroxybenzoate, 0.5 part of Phenoxyethanol, 0.1 part of Chlorphenesin, 0.5 part of potassium chloride, 1 part of propylene glycol and 5 parts of fourths two Alcohol, surplus are deionized water.

Embodiment 6

A kind of antisenility skin care hydrogel mask matrix, based on hydrogel mask matrix described in 100 parts by weight it includes with The component of lower parts by weight: 1 part of tremella polysaccharides, 2 parts of grape seed extracts, 1 part of Gotu Kola P.E, 1 part of hamamelis are extracted Object and 2 parts of dendrobium candidum extracts；2 parts of collagens, 1 part of palmityl tripeptides -1 and 2 parts of palmityl tetrapeptides -7；2 parts of dipotassium glycyrrhizinates With 1 part of allantoin；0.01 part of polyglutamic acid, 0.5 part of Sodium Hyaluronate and 2 parts of tetrahydro methylpyrimidine carboxylic acids；1 part of EDETATE SODIUM, 5 Part glycerol, 1.5 parts of polysorbate -20,5 parts of Chondrus crispus powder, 0.1 part of algaroba glue, 2 parts of hydroxyethyl celluloses, 1.5 parts Carbomer, 0.05 part of methyl hydroxybenzoate, 0.5 part of Phenoxyethanol, 0.3 part of Chlorphenesin, 1 part of potassium chloride, 1 part of propylene glycol and 6 parts of fourths Glycol, surplus are deionized water.

Test case 1: microorganism and hygienic chemistry detection

Antisenility skin care hydrogel facial mask made from the embodiment 1-6 of three different batches is randomly selected, is carried out respectively micro- Biological detection and hygienic chemistry detection, examination criteria carry out according to " cosmetics safety technical specification " (version in 2015), as a result divide Not as shown in following table 1 and table 2.

Table 1: microorganism detection result

Inspection project	Inspection result	Limit value
			Total plate count (CFU/g)	<10	≤1000
Yeast and mold sum (CFU/g)	<10	≤100
			Heat-resisting coliform/g	It is not detected	It must not detect
Staphylococcus aureus/g	It is not detected	It must not detect
			Pseudomonas aeruginosa/g	It is not detected	It must not detect

Table 2: hygienic chemistry testing result

Inspection project	Unit	Inspection result	The method of inspection	Concentrations	Limit value
						Mercury	mg/kg	It is not detected	Hydride generation atomic fluorescence photometry	0.01	≤1
Arsenic	mg/kg	It is not detected	Hydride generation atomic fluorescence photometry	0.05	≤2
						Lead	mg/kg	It is not detected	Atomic absorption spectrophotometry	5.0	≤10
Cadmium	mg/kg	It is not detected	Atomic absorption spectrophotometry	1.0	≤5
						Dioxanes	mg/kg	It is not detected	Gas chromatography mass spectrometry	3.0	≤30

From the testing result of the above Tables 1 and 2 it is found that by antisenility skin care hydrogel mask matrix preparation of the invention Corresponding hydrogel facial mask, quality measurements meet the requirement of state quality standard.

Test case 2: skin improves efficacy assessments

Female volunteers of 175 ages in 35-55 one full year of life are randomly selected, the reality for randomly selecting three different batches is used Anti-aging hydrogel facial mask made from a 1-6 is applied to be tested as a control group as sample sets and common moisture saver mask, with Machine is divided into seven groups, and every group of 25 people, volunteer signs voluntary book before testing.Volunteer exist skin of face it is coarse, relaxation, or The skin agings phenomenons such as wrinkle intensification.Volunteer clean face after, constant temperature and humidity (22-25 DEG C of room temperature, humidity 40- 60%) environmental balance after forty minutes, by profilograph and takes pictures and assesses the skin of face situation of volunteer, obtains initial Value.Then by 1-6 of the embodiment of the present invention hydrogel film sample and common moisture saver mask control respectively give seven groups of volunteers Use, volunteer is daily in face using primary test film sample, after continuous use 2 months, then by profilograph and Assessment take pictures using test film sample rear face skin, obtains terminal value.

Using the initial value and terminal Value Data of statistical method analysis volunteer's face skin wrinkle situation, judge to volunteer It includes that skin is soft that person is improved using the situation of change and comprehensive skin of facial skin wrinkle after test hydrogel film sample The improvement (p>=of toughness and skin color 0.05 is no significant difference, p<0.05 is that there were significant differences), as a result as following Shown in table 3.

Table 3: anti-wrinkle effect (the facial skin variations in test front and back are indicated with " not significant " or " significant ")

Test result shows that, compared to common moisture saver mask control group, the hydrogel film sample of 1-6 of the embodiment of the present invention has There are good water lock and skin adaptability, significant anti-wrinkle effect and comprehensive skin are obtained after use improves effect.From The hydrogel film sample of embodiment 1-6 is compared in the comparison of the effect of common moisture saver mask control group as can be seen that of the invention Hydrogel film sample has apparent advantage compared to common moisture saver mask.

Although above the present invention is described in detail with a general description of the specific embodiments, On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.

Claims

1. a kind of antisenility skin care hydrogel composition, which is characterized in that the composition includes natural extract, polypeptide, resists Scorching agent and moisturizer, wherein the natural extract is for three kinds below, four kinds or all: tremella (Tremella Fuciformis) polysaccharide, grape (Vitis vinifera) seed extract, centella (Centella asiatica) extract, Hamamelis (Hamamelis virginiana) extract and dendrobium candidum (Dendrobium candidum) extract, The polypeptide are as follows: collagen, palmityl tripeptides -1 and palmityl tetrapeptide -7, the anti-inflammatory agent are as follows: dipotassium glycyrrhizinate and allantoin, institute State moisturizer are as follows: polyglutamic acid, Sodium Hyaluronate and tetrahydro methylpyrimidine carboxylic acid；And

The composition further includes chelating agent, dispersing agent, emulsifier, thickener, preservative, buffer and solvent, wherein described Chelating agent is EDETATE SODIUM, and the dispersing agent is glycerol, and the emulsifier is polysorbate -20, and the thickener is ripple Irish moss (Chondrus crispus) powder, algaroba (Ceratonia siliqua) glue, hydroxyethyl cellulose and carbomer, The preservative is methyl hydroxybenzoate, Phenoxyethanol and Chlorphenesin, and the buffer is potassium chloride, and the solvent is water, the third two Pure and mild butanediol.

2. hydrogel composition as described in claim 1, which is characterized in that based on hydrogel composition described in 100 parts by weight It includes each components with following parts by weight: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape seed extracts, 0.01-2 parts of products Avenge careless extract, 0.01-2 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；And

The composition further includes chelating agent, dispersing agent, emulsifier, thickener, preservative, buffer and solvent, wherein described Chelating agent is EDETATE SODIUM, and the dispersing agent is glycerol, and the emulsifier is polysorbate -20, and the thickener is ripple Irish moss powder, algaroba glue, hydroxyethyl cellulose and carbomer, the preservative are that methyl hydroxybenzoate, Phenoxyethanol and chlorobenzene are sweet Ether, the buffer are potassium chloride, and the solvent is water, propylene glycol and butanediol.

3. a kind of antisenility skin care hydrogel mask matrix, which is characterized in that based on hydrogel mask matrix described in 100 parts by weight It includes each components with following parts by weight: 0.01-2 parts of tremella (Tremella fuciformis) polysaccharide, 0.01-2 parts of Portugals Grape (Vitis vinifera) seed extract, 0.01-2 parts of centella (Centella asiatica) extracts, 0.01-2 parts of north U.S. witch hazel (Hamamelis virginiana) extract and 0.01-2 parts of dendrobium candidums (Dendrobium candidum) mention Take object；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of glycyrrhizic acids two Potassium and 0.01-2 parts of allantoins；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidines Carboxylic acid；0.01-2 parts of EDETATE SODIUMs, 1-5 parts of glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus (Chondrus crispus) powder, 0.1-5 parts of algaroba (Ceratonia siliqua) glue, 0.1-2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 part of Chlorphenesin, 0.01- 2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

4. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape seed extracts, 0.01-2 Part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-1 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

5. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-2 parts of tremella polysaccharides, 0.01-1 parts of grape seed extracts, 0.01-2 Part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-1 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

6. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-2 parts of tremella polysaccharides, 0.01-2 parts of grape seed extracts, 0.1-1 Part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

7. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-1 parts of tremella polysaccharides, 0.01-2 parts of grape seed extracts, 0.01-2 Part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

8. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-1 parts of tremella polysaccharides, 0.01-1 parts of grape seed extracts, 0.01-2 Part Gotu Kola P.E, 0.01-2 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

9. hydrogel mask matrix as claimed in claim 3, which is characterized in that based on hydrogel facial mask described in 100 parts by weight It includes each components with following parts by weight for matrix: 0.01-1 parts of tremella polysaccharides, 0.01-2 parts of grape seed extracts, 0.01-1 Part Gotu Kola P.E, 0.01-1 parts of hamamelis extracts and 0.01-2 parts of dendrobium candidum extracts；0.01-2 parts of collagens, 0.01-2 parts of palmityl tripeptides -1 and 0.01-2 parts of palmityl tetrapeptides -7；0.01-2 parts of dipotassium glycyrrhizinates and 0.01-2 parts of allantois Element；0.01-2 parts of polyglutamic acids, 0.01-2 parts of Sodium Hyaluronates and 0.01-2 parts of tetrahydro methylpyrimidine carboxylic acids；0.01-2 parts of EDTA Disodium, 1-5 part glycerol, 0.01-2 parts of polysorbate -20,0.1-5 parts of Chondrus crispus powder, 0.1-5 parts of algaroba glue, 0.1- 2 parts of hydroxyethyl celluloses, 0.1-2 parts of carbomers are no more than 0.2 part of methyl hydroxybenzoate, are no more than 1 part of Phenoxyethanol, are no more than 0.3 Part Chlorphenesin, 0.01-2 parts of potassium chloride, 0.5-2 parts of propylene glycol and 0.3-6 parts of butanediols, surplus are deionized water.

10. a kind of method for preparing hydrogel mask matrix described in any one of claim 3-9, which is characterized in that including Following steps:

1) following components of corresponding parts by weight is uniformly mixing to obtain in suitable quantity of water solution A and is heated to 70 DEG C: glycerol, the third two Alcohol, Chondrus crispus powder, algaroba glue, potassium chloride, hydroxyethyl cellulose, EDETATE SODIUM, allantoin, carbomer, polysorbate Ester -20；

2) following components of corresponding parts by weight is dissolved in solution A under heating and uniform stirring and obtains solution B: butanediol, Collagen, polyglutamic acid, Sodium Hyaluronate, tremella polysaccharides, grape seed extract, Gotu Kola P.E, hamamelis extract, Dendrobium candidum extract, dipotassium glycyrrhizinate, palmityl tripeptides -1, palmityl tetrapeptide -7 and tetrahydro methylpyrimidine carboxylic acid；

3) following components of corresponding parts by weight is added in solution B under uniform stirring and obtains solution C and is heated to 80 DEG C: hydroxyl Benzene methyl, Phenoxyethanol and Chlorphenesin；