KR20050110720A - Cosmetic composition for moisturizing effect on the skin - Google Patents

Abstract

The present invention relates to a cosmetic composition for moisturizing the skin, and more particularly, as the active ingredient, the extract from the horticultural extract and Astragalus extract further contains cornus extract or sewage extract, the pulling, roughness and elasticity of the skin, which are often caused by skin changes in women. It relates to a skin moisturizing cosmetic composition that improves the skin drying phenomenon such as lack.

Description

Cosmetic composition for skin moisturizing {Cosmetic composition for moisturizing effect on the skin}

The present invention relates to a cosmetic composition for moisturizing the skin, and more particularly, as the active ingredient, the extract from the horticultural extract and Astragalus extract further contains cornus extract or sewage extract, the pulling, roughness and elasticity of the skin, which are often caused by skin changes in women. It relates to a skin moisturizing cosmetic composition that improves the skin drying phenomenon such as lack.

The skin is divided into three layers of epidermis, dermis and subcutaneous tissue in order from the outside, and it protects the organs of the body from temperature and humidity changes, ultraviolet rays and other physical and chemical external stimuli. In particular, the epidermis plays an important role in preventing evaporation of moisture inside the human body.

The epidermis is divided into the stratum corneum, granule layer, pore layer, and basal layer in order from the outside, the cells of the stratum corneum act like a brick and the intercellular lipids between the stratum corneum act as a mortar to form a skin barrier ( J. Invest.Drmatol. 80 (Suppl.), 44-49. 1983. In addition, the keratinocytes of healthy people have a high concentration of Natural Moisturing Factor (NMF) to help the skin retain moisture. For example, because amino acids, such as amino acids, are water soluble, they effectively combine with moisture Inhibit drying (J. Invest. Dermatol. 54, 24-31, 1970).

However, these days, the artificial temperature control of air conditioning and heating according to the change of environment and life patterns, the skin stress caused by various stresses and environmental pollution that occur in social life, the frequent face wash due to makeup habits and the increase of age The need for skin moisturizers is increasing because the moisture in the stratum corneum decreases due to various causes such as normal skin aging, and the skin becomes dry, the surface is rough, the skin becomes crumbly and moisturized, and it appears to be lifeless. .

Conventionally, a method of increasing moisture retention in the stratum corneum by using a humectant having a property of absorbing moisture or an occlusive moisturizer that prevents evaporation of moisture as a moisturizing agent is used. Examples of the humectant include glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, and 2-pyrrolidone-5-sodium carboxylate, but are very sticky or damp when applied to the skin. There is a drawback to feeling. In addition, as a closed moisturizer, lipid components such as ceramide, essential fatty acids and lipid complexes were used (J. Invest. Dermatol. (5), 731-740, 1994), but it is difficult to maintain the stability of the emulsion formulation and is transparent. There are disadvantages in inadequate preparation of gelled products.

However, in recent years, the claim that differentiation of the stratum corneum is important to prevent drying of the skin moisture, and the differentiation process that develops from the basal keratinocytes to the outermost stratum corneum cells should be performed normally to act as a skin moisture barrier. It turns out that you can. That is, during the process of keratinization, the cells produce natural moisturizing factors and intercellular lipids, and as a result, the stratum corneum becomes firm and flexible, thus functioning as a barrier. Physiologically, the tendency of the skin to dry with age increases, which can be interpreted as increasing the dropout time of the stratum corneum, decreasing the lipid synthesis ability of epidermal cells, and decreasing the amount of moisturizing factors and lipids in the stratum corneum. . Thus, by accelerating the differentiation of keratinocytes, a new approach has been made that can induce a strengthening of the skin barrier and enhance skin moisture retention and protection from the external environment.

Accordingly, the present inventors have studied cosmetic compositions having excellent skin moisturizing effect and excellent formulation stability when applied to the skin and are not sticky or dull, and have produced cosmetics containing cornus extracts or sewage extracts in cheonung extracts and astragalus extracts. It was confirmed that the skin moisturizing effect was actually excellent when applied to the skin of the present invention, by revealing that the moisturizing effect was made by inducing the strengthening of the skin barrier by promoting the differentiation of keratinocytes to improve the skin moisture retention function, It was completed.

Accordingly, an object of the present invention is to further improve the skin moisturizing effect, skin roughness, moisture deficiency by improving the skin moisturizing effect by further containing a cornus extract or sewage extract in cheongung extract and Astragalus extract as an active ingredient. It is to provide a cosmetic composition.

In order to achieve the above object, the skin moisturizing cosmetic composition according to the present invention is characterized in that it further comprises a cornus extract or sewage extract in the extract and Astragalus extract.

More preferably, the cosmetic composition for skin moisturizing according to the present invention contains 0.001 to 20% by weight of uterine extract, 0.001 to 20% by weight of Astragalus extract, 0.001 to 20% by weight of sewage extract, 0.001 to 20% by weight of cornus extract. It features.

Hereinafter, the present invention will be described in more detail.

Generally, Cnidium Officinale Root Extract is a component extracted from the roots and stems of Cnidium Officinale Makino. It is a component used for wound healing, skin regeneration, and antibacterial action.

In the present invention, the content of the uterine extract is preferably 0.001 to 20% by weight, and less than 0.001% by weight, the effect on the skin is insignificant.

Astragalus extract used in the present invention is a component extracted from the roots of Astragalus membranaceus or Astragalus mongholicus , saponins of the astragalalosides and polysaccharides of the astragalalan family, kaempferol, quercetin , Flavonoids such as isorhamnetin, calycosin, formononetin, rhamnocitrin, kumatakenin, asparagine, glutamic acid, proline, β-aminobutyric acid, It contains amino acids such as arginine and alanine, and it promotes the regeneration of skin tissues and enhances immune function, enhances the defense against external stimuli, and promotes blood circulation to smooth the nutrition supply to the skin. have.

The content of the Astragalus extract used in the present invention is preferably 0.001 to 20% by weight, and less than 0.001% by weight is not suitable for cosmetics because there is a slight effect on the skin, and more than 20% by weight may cause precipitation in the formulation.

Sewage extract used in the present invention is a Polygonum Multiflorum Root Extract, which is an ingredient extracted from the leaves, roots, berries, etc. of Polygonum Multiflorum Thunb, and is generally used for various skin diseases showing eczema or allergy symptoms.

In the present invention, the content of sewage extract is preferably 0.001 to 20% by weight, less than 0.001% by weight of the effect on the skin is weak and more than 20% by weight is not particularly suitable for cosmetics.

Cornus Officinalis Fruit Extract used in the present invention is a Cornus Officinalis Fruit Extract, which is extracted from the fruit of Cornus Officinalis sieb.et.Zucc., And is generally used to show effects such as wound healing and cytoprotective activity, cell proliferation, and metabolism promotion. It is an ingredient.

In the present invention, the preferred amount of cornus oil extract is 0.001 to 20% by weight, less than 0.001% is less effective for the skin and more than 20% by weight is not easy to dissolve in water and sticky feeling is not suitable as a cosmetic.

Hereinafter, although an Example and a test example are given and this invention is demonstrated more concretely, this invention is not limited only to these examples.

[Test Example 1] keratinocyte differentiation promoting effect

Human keratinocytes were placed in a culture flask, cultured, and grown to about 80%, and then the samples of Table 1 were each added at a concentration of 5 ppm and treated for 4 days. Next, a denatured protein such as urea or sodium dodecyl sulfate (SDS) and a reducing agent such as β-mercaptoethanol were mixed to remove the dissolved protein. Then, the peptide concentration was analyzed by measuring the absorbance at 310 nm of the remaining stratum corneum, and the results are shown in Table 1 by comparing the increase by each sample based on distilled water as a negative control (0%).

matter Keratinocyte differentiation promoting effect Shouao 68% Cornus 55% Cheongung 32% Astragalus 43% Distilled Water (Negative Control) 0%

From the results in Table 1, it was confirmed that the keratinocyte differentiation promoting effect of the materials used in the present invention is very excellent.

EXAMPLES 1-3 AND COMPARATIVE EXAMPLES 1-3 Production of cosmetics for skin moisturizing

After dissolving the water parts up to components 1 to 8 and the alcohol parts up to components 9 to 12 in the composition shown in Table 2 at room temperature, the alcohol parts were gradually added to the aqueous phase while solubilizing with stirring. Next, stirring was continued for about 3-5 minutes after the addition of the alcohol parts was completed, followed by vacuum degassing to complete the preparation of the cosmetic.

Ingredients (content; weight percent) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 1.Purified water to100 to100 to100 to100 to100 to100 2.glycerine 3 3 3 3 3 3 3.Carbomer 0.2 0.2 0.2 0.2 0.2 0.2 4.triethanolamine 0.18 0.18 0.18 0.18 0.18 0.18 5. Sewage Extract - One - One - One 6.Horse Extract - One - - One One 7.Certex Extract - - One One One One 8.Astragalus Extract - - One One One One 9.ethanol 3 3 3 3 3 3 10.Polyoxyethylene Hydrogenated Castor Oil 0.3 0.3 0.3 0.3 0.3 0.3 11. Incense Quantity Quantity Quantity Quantity Quantity Quantity 12. Preservative Quantity Quantity Quantity Quantity Quantity Quantity

Test Example 2 Skin Barrier Function Restoration Effect

After repeated application of acetone to the skin of hairless mice, the barrier function was impaired. After reaching, the sample containing the composition of Table 2 was applied to an area of 5 cm 2, and the barrier function was restored by evaluating the extent to which the epidermal moisture loss was reduced after 1 hour, 2 hours, 4 hours and 8 hours. The degree to which it was made was evaluated. At this time, a known lipid mixture (2: 1: 1 mixture of ceramide: cholesterol: fatty acid) was used as a positive control. The results are shown in Table 3 below comparing the changes over time based on the amount of epidermal moisture loss in the initial damaged barrier state (100%).

Epidermal moisture loss (%) sample 1 hour later 2 hours later 4 hours later 8 hours later Comparative Example 1 80 88 75 70 Comparative Example 2 64 51 48 37 Comparative Example 3 77 61 49 36 Example 1 62 54 41 27 Example 2 57 51 35 24 Example 3 50 43 36 21 Geological Mixture (Yangseong Control Group) 64 43 37 26

As can be seen from the results, it can be confirmed that the skin barrier function recovery effect of Examples 1 to 3 according to the present invention is very excellent compared to Comparative Examples 1 to 3.

[Test Example 3] skin moisture content increase effect

Experimental effect of improving the skin moisturizing power for the cosmetic prepared in the composition of Table 2.

First, divided into seven groups of 20 people per group for 140 people in their 20s to 30s without skin diseases, and give each group a positive control group with Examples 1 to 3 and Comparative Examples 1 to 3 as in Test Example 2, respectively. 2 times daily for 1 month on face and forearm. Before starting the application, measure the skin conductivity using a corneometer (CM820 courage Khazaka electronic GmbH, Germany) at constant temperature and humidity conditions (24 ° C, 40% humidity), and after 1 week, 2 weeks, and 4 weeks And skin conductivity two weeks after application discontinuation (6 weeks) and the rate of increase was evaluated. The results are shown in Table 4 below.

Skin conductivity increase rate (%) sample 1 week later after 2 weeks 4 weeks later 8 weeks later Comparative Example 1 11 14 17 9 Comparative Example 2 42 44 49 26 Comparative Example 3 43 46 50 36 Example 1 57 62 59 42 Example 2 56 61 66 54 Example 3 58 66 71 59 Geological Mixture (Yangseong Control Group) 62 65 63 43

Since the skin conductivity is proportional to the skin moisture content, it was confirmed that the effect of increasing the skin moisture content of Examples 1 to 3 according to the present invention is very excellent in the results of Table 4 above. In addition, in the case of Examples 2 to 3, even after two weeks of discontinuation (after six weeks in total), it was found that the moisture content was maintained higher than that of the other examples, thereby providing a long term moisturizing effect.

[Test Example 4]

The subjects of Test Example 3 were subjected to a subjective evaluation of efficacy through a questionnaire survey on skin pulling, roughness, and skin elasticity change after using Examples 1-3 and Comparative Examples 1-3. In the survey, the satisfaction level of the product for each item of skin pulling, roughness, and skin elasticity was classified by 1-5 points (the higher the number, the higher the satisfaction), and the results are shown in Table 5 below. .

sample Satisfaction (Average Score) Skin Pulling Improvement Skin Roughness Improvement Increased skin elasticity Comparative Example 1 1.7 1.4 2.2 Comparative Example 2 1.2 2.2 2.3 Comparative Example 3 2.7 3.5 2.7 Example 1 3.5 3.7 3.5 Example 2 4.3 4.5 4.0 Example 3 4.1 4.9 4.4

From the results of Table 5, it can be seen that in Examples 1 to 3 according to the present invention, the effects of improving skin pulling, roughness, and skin elasticity are superior to Comparative Examples 1 to 3.

As described above, the cosmetic composition containing sewage, cornus, celestial organs, and astragalus extract according to the present invention promotes the differentiation of keratinocytes of the skin and restores the skin barrier function, relieves skin pulling, roughness, and skin elasticity. Since it has the effect of increasing the skin can be usefully used as a moisturizing cosmetic.

Claims (2)

Cosmetic composition for skin moisturizing, characterized in that it contains at least one selected from the group consisting of sewage extract and cornus extract in cheongung extract and Astragalus extract as an active ingredient. According to claim 1, To the active ingredient in the total weight of the composition in the 0.001 to 20% by weight and 0.001 to 20% by weight of Astragalus extract; Sewage extract 0.001 to 20% by weight and 0.001 to 20% by weight of the extract of cornus oil, the skin moisturizing cosmetic composition, characterized in that it further contains at least one selected from the group consisting of.