CN112206308A - Nourishing and bacteriostatic gel and preparation method thereof - Google Patents
Nourishing and bacteriostatic gel and preparation method thereof Download PDFInfo
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Abstract
The application relates to the field of gynecological gel, and particularly discloses a nourishing and bacteriostatic gel and a preparation method thereof, wherein the nourishing and bacteriostatic gel is prepared from the following raw materials in parts by weight: 0.1-0.3 part of bioactive peptide; 0.05-0.2 part of marine glycoprotein; 2-4 parts of active polysaccharide; 15-20 parts of plant extract; 0.5-1.5 parts of sodium hyaluronate; 0.1-0.25 part of plant essential oil; 0.8-1.5 parts of lactic acid; 1-2 parts of carboxymethyl cellulose; 1-1.5 parts of glycerol; 1-2 parts of a pH regulator; 0.5-1.5 parts of emulsifier; purified water is made up to 100 parts. The nourishing and bacteriostatic gel can be used for gynecological bacteriostasis, and has the advantages of good bacteriostasis effect and skin moistening.
Description
Technical Field
The application relates to the field of gynecological gel, in particular to nourishing and bacteriostasis gel and a preparation method thereof.
Background
With the development of economy, the living standard of people is improved, the living rhythm is accelerated, and the number of people with sub-health inflammation on the body of a female is increased. At present, the conventional formulations commonly used for the topical treatment of gynecological inflammations mainly comprise: aqua, tablet, suppository, ointment, gel, etc.
The Chinese patent with publication number CN105997847A discloses an antibacterial gel, wherein each liter of antibacterial gel is composed of the following raw materials: 0.1-1.0 g of chlorhexidine acetate, 0.5-1.5ml of mung bean fermentation liquor, 10-20ml of alcohol, 371.0-4.0 g of polyquaternary ammonium salt, 2.0-8.0 g of 1.3-butanediol, 0.2-1.8 g of trehalose, 0.2-0.8 g of traditional Chinese medicine extract and the balance of purified water.
In view of the above-mentioned related technologies, the inventor believes that the antibacterial gel mainly uses synthetic drugs for bacteriostasis, and it is difficult to maintain the private skin while bacteriostasis.
Disclosure of Invention
In order to improve the bacteriostasis rate of the gel and simultaneously maintain the skin, the application provides a nourishing and bacteriostasis gel and a preparation method thereof.
In a first aspect, the application provides a nourishing and bacteriostatic gel, which adopts the following technical scheme:
the nourishing and bacteriostatic gel is prepared from the following raw materials in parts by weight:
0.1-0.3 part of bioactive peptide;
0.05-0.2 part of marine glycoprotein;
2-4 parts of active polysaccharide;
15-20 parts of plant extract;
0.5-1.5 parts of sodium hyaluronate;
0.1-0.25 part of plant essential oil;
0.8-1.5 parts of lactic acid;
1-2 parts of carboxymethyl cellulose;
1-1.5 parts of glycerol;
1-2 parts of a pH regulator;
0.5-1.5 parts of emulsifier;
purified water is complemented to 100 parts;
the plant extract is prepared from the following raw materials in parts by weight:
8-10 parts of sophora flavescens;
6-8 parts of phellodendron;
2-4 parts of fructus cnidii;
4-6 parts of salvia miltiorrhiza;
4-6 parts of safflower;
4-8 parts of motherwort;
1-2 parts of folium artemisiae argyi.
By adopting the technical scheme, as the plant extract, the plant essential oil and the lactic acid are compounded, the plant extract contains effective components for inhibiting candida albicans, escherichia coli and staphylococcus aureus, the plant essential oil, also called volatile oil, essential oil and aromatic oil, is a secondary metabolite which exists in aromatic plants, has volatility, is composed of simple compounds with small molecular weight and certain activity, can be distilled along with water vapor and cannot be mutually mixed with water, besides being used as a flavoring raw material, the plant essential oil has various functional effects, such as bacteriostasis, insecticidal action, antioxidation action and tissue cell regeneration promotion action, the lactic acid has antimicrobial property and can inhibit the growth of microorganisms, and the applicant finds that when the plant extract, the tea tree essential oil and the lactic acid are compounded for use, can realize synergistic effect and obviously improve the bacteriostasis rate.
Bioactive peptide is a kind of multifunctional compound from protein, has different biological activity, generally consists of several to dozens of amino acids, has different amino acid arrangement sequences and various structures, has better effect on reducing wrinkle depth, can enhance the elasticity and protein activity of private cells, maintains the cell renewal capacity, makes the cells more active and makes the vagina more compact; the marine glycoprotein is obtained from a marine psychrophile-pseudoalteromonas antarctica NF3 strain by a biotechnology, has the effect of improving skin adhesion, promotes skin reconstruction, and makes the skin more compact and elastic. The active polysaccharide can promote fibroblasts to synthesize collagen, promote wound healing, repair damaged skin, smooth wrinkles and improve elasticity. When the bioactive peptide, the marine glycoprotein and the active polysaccharide are compounded for use, the synergistic effect can be achieved, and the elasticity of the skin can be obviously enhanced.
Optionally, the active polysaccharide is composed of Schizophyllum commune polysaccharide and Ginkgo biloba polysaccharide.
By adopting the technical scheme, the Schizophyllum commune is a large fungus with high nutritive value and medicinal value, and Schizophyllum commune polysaccharide extracted from the large fungus has the physiological activities of inhibiting tumor, improving immunity of organisms, delaying aging, enhancing skin elasticity and the like; ginkgo polysaccharide can also enhance skin elasticity. The Schizophyllum commune polysaccharide and the gingko polysaccharide are compounded for use, so that the skin elasticity increasing rate can be improved.
Optionally, the ratio of the schizophyllum commune polysaccharide to the ginkgo polysaccharide in parts by weight is 1: (2-4).
By adopting the technical scheme, the Schizophyllum commune polysaccharide and the gingko polysaccharide can be synergized under a specific ratio, and the elasticity increasing rate is obviously improved.
Optionally, the plant essential oil consists of calendula essential oil and chamomile essential oil.
By adopting the technical scheme, the calendula essential oil is an extract of petals of calendula officinalis of Compositae and has an anti-aging effect. The calendula extract contains lutein and zeaxanthin, and the flowers and leaves have the effects of diminishing inflammation and resisting bacteria, and especially have good effects on staphylococcus and streptococcus. Chamomile essential oil can relieve the symptoms of inflammation and pain of patients. The chamomile contains cyclic ethers, flavonoids, total volatile oil and the like, and has different inhibiting effects on fungal breeding; chamomile is rich in flavonoid active ingredients, and the ingredients have antioxidant, anti-vascular proliferation, anti-inflammatory, antiallergic and antiviral effects. When the calendula essential oil and the chamomile essential oil are used in combination, the bacteriostatic rate can be improved.
Optionally, the weight part ratio of the calendula essential oil to the chamomile essential oil is 1: (1-3).
By adopting the technical scheme, the calendula essential oil and the chamomile essential oil can be synergized under a specific ratio, and the bacteriostasis rate is obviously improved.
Optionally, the nourishing and bacteriostasis gel is prepared from the following raw materials in parts by weight:
0.1 part of bioactive peptide;
marine glycoprotein 0.2 weight portions;
3 parts of active polysaccharide;
18 parts of plant extract;
1 part of sodium hyaluronate;
0.2 part of plant essential oil;
1 part of lactic acid;
1.5 parts of carboxymethyl cellulose;
1.2 parts of glycerol;
1.5 parts of a pH regulator;
1 part of an emulsifier;
purified water is complemented to 100 parts;
the plant extract is prepared from the following raw materials in parts by weight:
9 parts of sophora flavescens;
7 parts of phellodendron;
3 parts of fructus cnidii;
5 parts of salvia miltiorrhiza;
4 parts of safflower;
6 parts of motherwort;
and 2 parts of folium artemisiae argyi.
By adopting the technical scheme, the antibacterial effect and the skin elasticity increasing effect of the gel are better in the proportion.
In a second aspect, the application provides a preparation method of the nourishing and bacteriostasis gel, which adopts the following technical scheme:
a preparation method of the nourishing and bacteriostasis gel comprises the following steps:
step one, adding a proper amount of purified water into lactic acid, and dissolving to obtain a lactic acid solution;
step two, crushing radix sophorae flavescentis, golden cypress, fructus cnidii, salvia miltiorrhiza, safflower, motherwort and folium artemisiae argyi into coarse powder, and extracting by using a percolation method to obtain a plant extract;
dissolving carboxymethyl cellulose, bioactive peptide, active polysaccharide and sodium hyaluronate in a proper amount of purified water, standing for 10-12 hours to fully swell the carboxymethyl cellulose, and uniformly stirring to obtain a gel matrix;
step four, diluting the plant essential oil and the glycerol with a proper amount of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;
and step five, adding the lactic acid solution, the plant extract and the essential oil mixture into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator under a stirring state until the pH is 4-6, and uniformly stirring to obtain the gel.
By adopting the technical scheme, the obtained gel has hydrophilicity, the macromolecular active polysaccharide and the bioactive peptide in the gel have water absorption, and swell after water absorption to form a 3D framework, wherein active ingredients such as traditional Chinese medicine micromolecular active ingredients and moisturizing ingredients are wrapped in the gel, and the gel has the functions of resisting bacteria, resisting trichomonad, relieving itching, activating cell vitality of female private parts, promoting tissue repair capacity and the like, and can enable the private parts to be healthier, more compact and more moist.
Optionally, the second step specifically includes: pulverizing radix Sophorae Flavescentis, cortex Phellodendri, fructus Cnidii, Saviae Miltiorrhizae radix, Carthami flos, herba Leonuri, and folium Artemisiae Argyi into coarse powder, extracting by percolation, soaking in 55% ethanol for 5-7 days, slowly percolating, soaking for 3-5 days, slowly percolating, squeezing the residue, mixing percolates for 2 times, decolorizing with active carbon, recovering ethanol, standing for more than 24 hr, recovering ethanol, and concentrating to relative density of 1.08-1.10 at 60 deg.C to obtain plant extract.
By adopting the technical scheme, the method can fully extract the effective components in the plants.
In summary, the present application has the following beneficial effects:
1. when the plant extract, the tea tree essential oil and the lactic acid are compounded for use, the synergistic effect can be achieved, and the antibacterial rate is obviously improved; when the bioactive peptide, the marine glycoprotein and the active polysaccharide are compounded for use, the synergistic effect can be achieved, and the elasticity of the skin can be obviously enhanced.
2. In the application, the Schizophyllum commune polysaccharide and the gingko polysaccharide are preferably compounded for use, so that the elasticity increasing rate of the skin can be improved, and the Schizophyllum commune polysaccharide and the gingko polysaccharide can be synergized under a specific ratio, so that the elasticity increasing rate is obviously improved.
3. Preferred calendula essential oil and chamomile essential oil are used in cooperation in the application, and the bacteriostasis rate can be improved. And the calendula essential oil and the chamomile essential oil can be synergized under a specific ratio, so that the bacteriostasis rate is obviously improved.
Detailed Description
The present application will be described in further detail with reference to examples.
Examples
Example 1
The preparation method of the nourishing and bacteriostasis gel comprises the following steps:
step one, adding 10g of purified water into lactic acid, and dissolving to obtain a lactic acid solution;
pulverizing radix sophorae flavescentis, golden cypress, fructus cnidii, salvia miltiorrhiza, safflower, leonurus and folium artemisiae argyi into coarse powder, extracting by using a percolation method, using 55% ethanol as a solvent, adding 2 times of ethanol by weight of the coarse powder for the first time, soaking for 5 days, slowly percolating, adding 3 times of ethanol by weight of the coarse powder for the second time, soaking for 3 days, slowly percolating, squeezing medicine residues, combining 2 times of percolate, mixing uniformly, decoloring by using active carbon, recovering and standing for more than 24 hours, recovering ethanol, and concentrating to a relative density of 1.08-1.10 at 60 ℃ to obtain a plant extract;
dissolving carboxymethyl cellulose, bioactive peptide, marine glycoprotein, active polysaccharide and sodium hyaluronate in 20g of purified water, standing for 10 hours to fully swell the carboxymethyl cellulose, and uniformly stirring to obtain a gel matrix;
step four, diluting the plant essential oil and the glycerol with 2g of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;
and step five, adding the lactic acid solution, the plant extract and the essential oil mixture into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator to a pH value of 4 under a stirring state, and uniformly stirring to obtain the gel.
The plant extract is prepared from the following raw materials in parts by weight: 8g of radix sophorae flavescentis; 6g of phellodendron; 2g of fructus cnidii; 4g of salvia miltiorrhiza; 4g of safflower; 4g of motherwort herb; 1g of folium artemisiae argyi.
The active polysaccharide is angelica polysaccharide, the plant essential oil is tea tree essential oil, the tea tree essential oil is obtained from Guangzhou Wuzhitang Biotechnology Co., Ltd, the pH regulator is sodium hydroxide, the emulsifier is Tween 80, the bioactive peptide is acetyl hexapeptide-8, and the marine glycoprotein is obtained from Spanish Riptotay.
Example 2
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the nourishing and bacteriostasis gel is prepared from the raw materials shown in the table 1. The plant extract is prepared from the following raw materials in parts by weight: 9g of radix sophorae flavescentis; 7g of phellodendron; 3g of fructus cnidii; 5g of salvia miltiorrhiza; 5g of safflower; 6g of motherwort herb; 1.5g of folium artemisiae argyi.
Example 3
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the nourishing and bacteriostasis gel is prepared from the raw materials shown in the table 1. The plant extract is prepared from the following raw materials in parts by weight: 10g of radix sophorae flavescentis; 8g of phellodendron amurense; fructus cnidii 4 g; 6g of salvia miltiorrhiza; 6g of safflower; 8g of motherwort herb; folium Artemisiae Argyi 2 g.
Example 4
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the nourishing and bacteriostasis gel is prepared from the raw materials shown in the table 1.
TABLE 1 materials and weights (g) for examples 1-4
Example 5
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide consists of 2g of Schizophyllum commune polysaccharide and 2g of gingko polysaccharide.
Example 6
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide is composed of 0.57g of Schizophyllum commune polysaccharide and 3.43g of gingko polysaccharide.
Example 7
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide consists of 1.33g of Schizophyllum commune polysaccharide and 2.67g of gingko polysaccharide.
Example 8
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide consists of 1g of Schizophyllum commune polysaccharide and 3g of gingko polysaccharide.
Example 9
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide is composed of 0.8g of Schizophyllum commune polysaccharide and 3.2g of gingko polysaccharide.
Example 10
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that active polysaccharide is replaced by Schizophyllum commune polysaccharide.
Example 11
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the active polysaccharide is replaced by ginkgo biloba polysaccharide.
Example 12
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil consists of 0.134g of calendula essential oil and 0.066g of chamomile essential oil.
Example 13
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil consists of 0.033g of calendula essential oil and 0.167g of chamomile essential oil.
Example 14
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil consists of 0.1g of calendula essential oil and 0.1g of chamomile essential oil.
Example 15
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil consists of 0.066g of calendula essential oil and 0.134g of chamomile essential oil.
Example 16
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil is composed of 0.05g of calendula essential oil and 0.15g of chamomile essential oil.
Example 17
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil is calendula essential oil.
Example 18
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that the plant essential oil is chamomile essential oil.
Example 19
The difference between the nourishing and bacteriostasis gel and the embodiment 1 is that the preparation method of the nourishing and bacteriostasis gel comprises the following steps:
step one, adding 10g of purified water into lactic acid, and dissolving to obtain a lactic acid solution;
pulverizing radix sophorae flavescentis, golden cypress, fructus cnidii, salvia miltiorrhiza, safflower, leonurus and folium artemisiae argyi into coarse powder, extracting by using a percolation method, using 55% ethanol as a solvent, adding 3 times of ethanol by weight of the coarse powder for the first time, soaking for 7 days, slowly percolating, adding 4 times of ethanol by weight of the coarse powder for the second time, soaking for 5 days, slowly percolating, squeezing medicine residues, combining 2 times of percolate, uniformly mixing, decoloring by using active carbon, recovering and standing for more than 24 hours, recovering ethanol, and concentrating to a relative density of 1.08-1.10 at 60 ℃ to obtain a plant extract;
dissolving carboxymethyl cellulose, bioactive peptide, marine glycoprotein, active polysaccharide and sodium hyaluronate in 20g of purified water, standing for 12 hours to fully swell the carboxymethyl cellulose, and uniformly stirring to obtain a gel matrix;
step four, diluting the plant essential oil and the glycerol with 2g of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;
and step five, adding the lactic acid solution, the plant extract and the essential oil mixture into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator to a pH value of 6 under a stirring state, and uniformly stirring to obtain the gel.
Comparative example
Comparative example 1
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that sodium hyaluronate, bioactive peptide, marine glycoprotein, active polysaccharide and glycerol are not added.
Comparative example 2
A nourishing and bacteriostatic gel is different from the gel in comparative example 1 in that 0.1g of bioactive peptide is added.
Comparative example 3
A nourishing and bacteriostasis gel is different from the gel in comparative example 1 in that 0.05g of marine glycoprotein is added.
Comparative example 4
A nourishing and bacteriostatic gel is different from the gel in comparative example 1 in that 4g of active polysaccharide is added.
Comparative example 5
The nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that sodium hyaluronate and glycerol are not added.
Comparative example 6
A nourishing and bacteriostasis gel is different from the gel in the embodiment 1 in that bioactive peptide, active polysaccharide, plant extract, plant essential oil and lactic acid are not added.
Comparative example 7
A nourishing and antibacterial gel is different from comparative example 6 in that 15g of plant extract is added.
Comparative example 8
A nourishing and bacteriostasis gel is different from the gel in the comparative example 6 in that 0.1g of plant essential oil is added.
Comparative example 9
A nourishing and bacteriostatic gel is different from the gel in comparative example 6 in that 1.5g of lactic acid is added.
Comparative example 10
A nourishing and antibacterial gel is different from comparative example 6 in that 15g of plant extract, 0.1g of plant essential oil and 1.5g of lactic acid are added.
Performance test
Test method
(1) The gels of examples 1 to 4, examples 12 to 19 and comparative examples 6 to 10 were tested for their bacteriostatic rate against E.coli (8099), Candida albicans (ATCC10231) and Staphylococcus aureus (ATCC6538) for 10min according to the test conditions in GB15979-2002, appendix C4 of hygienic Standard for Disposable sanitary articles and 2002, and the tests were repeated three times, taking the mean value, the bacteriostatic test being a carrier test, and the test temperature being 20 ℃. + -. 1 ℃.
(2) Recruiting 16 volunteers, cleaning the inner side of a handle by a tester, naturally drying, sitting for 15min in a room with constant temperature and humidity, marking the inner side of the arm of the tester, performing blank test by using a skin elasticity tester, and recording 4 skin elasticity data; the gels of examples 1 to 11 and comparative examples 1 to 5 were applied to 16 volunteers, respectively, and continuously applied once a day with the same amount of each application, and skin elasticity was measured after 5, 10, and 15 days of application, and the increase rate of skin elasticity was calculated.
TABLE 2 results of the bacteriostatic ratio test
Table 3 skin elasticity test results
By combining the examples 1-4, the examples 12-19 and the comparative examples 6-10 and combining the table 2, it can be seen that the bacteriostatic rates of the examples 1-3 on three pathogenic bacteria are all above 80% by adopting the plant extracts, the plant essential oils and the lactic acid in combination, which indicates that the bacteriostatic gel has a strong bacteriostatic action. Comparative example 6 is not added with bacteriostatic components, the bacteriostatic rate is 0%, comparative example 7 is about 72% after adding the plant extract on the basis of comparative example 6, comparative example 8 is about 65% after adding the tea tree essential oil on the basis of comparative example 6, comparative example 9 is about 62% after adding the lactic acid on the basis of comparative example 6, which shows that the plant extract, the tea tree essential oil and the lactic acid all have certain bacteriostatic action, and comparative example 10 is about 79% after simultaneously adding the plant extract, the tea tree essential oil and the lactic acid on the basis of comparative example 6, which shows that the plant extract, the tea tree essential oil and the lactic acid can be synergized and the bacteriostatic rate can be remarkably improved when being used in a compounding way.
Examples 17 and 18 respectively replace the tea tree essential oil with the calendula officinalis essential oil and the chamomile essential oil, the bacteriostatic rates of the calendula officinalis essential oil and the chamomile essential oil are slightly improved, which indicates that the bacteriostatic rates of the calendula officinalis essential oil and the chamomile essential oil are slightly higher than those of the tea tree essential oil, and examples 12 and 13 show that the bacteriostatic rate is slightly higher than those of examples 17 and 18 when the calendula officinalis essential oil and the chamomile essential oil are compounded for use, which indicates that the bacteriostatic effect is better when the calendula officinalis essential oil and the chamomile essential oil are compounded for use; in the embodiments 14 to 16, when the calendula essential oil and the chamomile essential oil are in the range of the mixture ratio of the application, the bacteriostasis rate is further improved and is higher than that of the case that one essential oil is singly used, which shows that the calendula essential oil and the chamomile essential oil can be synergistic under a specific mixture ratio, and the bacteriostasis is remarkably improved.
As can be seen by combining examples 1-11 and comparative examples 1-5 and combining Table 3, the skin elasticity increasing rate of examples 1-3 adopting the combination of bioactive peptides, marine glycoproteins and active polysaccharides is more than 11% after continuous use for 15 days, which shows that the bacteriostatic gel of the application can enhance the elasticity of the skin. Comparative example 1 when no bioactive peptide, marine glycoprotein and active polysaccharide were added, the skin elasticity increase rate was 0%, in comparative example 2, after the bioactive peptide was added based on comparative example 1, the skin elasticity increase rate was increased to 3.5% in 15 days, in comparative example 3, after the marine glycoprotein was added based on comparative example 1, the skin elasticity increase rate was increased to 2.2% in 15 days, in comparative example 4, after the active polysaccharide was added based on comparative example 1, the skin elasticity increase rate was increased to 2.9% in 15 days, indicating that the bioactive peptide, marine glycoprotein and active polysaccharide all can enhance the skin elasticity, in comparative example 5, after the bioactive peptide, marine glycoprotein and active polysaccharide were added together based on comparative example 1, the skin elasticity increase rate was increased to 10.6% in 15 days, which is higher than that of the bioactive peptide, marine glycoprotein and active polysaccharide alone, indicating that the bioactive peptide, marine glycoprotein and active polysaccharide were used alone, When the marine glycoprotein and the active polysaccharide are compounded for use, the synergistic effect can be realized, and the elasticity of the skin can be obviously enhanced.
Examples 10 and 11 replace the angelica polysaccharide with the schizophyllum commune polysaccharide and the ginkgo polysaccharide respectively, the elasticity increasing rate of the schizophyllum commune polysaccharide and the ginkgo polysaccharide is slightly improved, which indicates that the schizophyllum commune polysaccharide and the ginkgo polysaccharide are slightly better than the angelica polysaccharide in the aspect of enhancing the skin elasticity, when the schizophyllum commune polysaccharide and the ginkgo polysaccharide are compounded and used in examples 5 and 6, the elasticity increasing rate is slightly higher than that of examples 10 and 11, which indicates that the elasticity increasing rate is further improved when the schizophyllum commune polysaccharide and the ginkgo polysaccharide are compounded and used; examples 7 to 9 further improve the elasticity increase rate of the schizophyllum commune polysaccharide and the ginkgo biloba polysaccharide within the range of the mixture ratio of the application, and the elasticity increase rate is higher than that of the schizophyllum commune polysaccharide and the ginkgo biloba polysaccharide which are singly used, which shows that the schizophyllum commune polysaccharide and the ginkgo biloba polysaccharide can synergize under the specific mixture ratio, and the elasticity increase rate is obviously improved.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. The nourishing and bacteriostasis gel is characterized by being prepared from the following raw materials in parts by weight:
0.1-0.3 part of bioactive peptide;
0.05-0.2 part of marine glycoprotein;
2-4 parts of active polysaccharide;
15-20 parts of plant extract;
0.5-1.5 parts of sodium hyaluronate;
0.1-0.25 part of plant essential oil;
0.8-1.5 parts of lactic acid;
1-2 parts of carboxymethyl cellulose;
1-1.5 parts of glycerol;
1-2 parts of a pH regulator;
0.5-1.5 parts of emulsifier;
purified water is complemented to 100 parts;
the plant extract is prepared from the following raw materials in parts by weight:
8-10 parts of sophora flavescens;
6-8 parts of phellodendron;
2-4 parts of fructus cnidii;
4-6 parts of salvia miltiorrhiza;
4-6 parts of safflower;
4-8 parts of motherwort;
1-2 parts of folium artemisiae argyi.
2. The nourishing bacteriostatic gel according to claim 1, wherein: the active polysaccharide comprises Schizophyllum commune polysaccharide and Ginkgo biloba polysaccharide.
3. The nourishing bacteriostatic gel according to claim 2, wherein: the ratio of the schizophyllum commune polysaccharide to the ginkgo polysaccharide in parts by weight is 1: (2-4).
4. The nourishing bacteriostatic gel according to claim 1, wherein: the plant essential oil consists of calendula essential oil and chamomile essential oil.
5. The nourishing bacteriostatic gel according to claim 4, wherein: the calendula essential oil and chamomile essential oil comprise the following components in parts by weight: (1-3).
6. The nourishing bacteriostatic gel according to claim 1, wherein: the nourishing and bacteriostatic gel is prepared from the following raw materials in parts by weight:
0.1 part of bioactive peptide;
marine glycoprotein 0.2 weight portions;
3 parts of active polysaccharide;
18 parts of plant extract;
1 part of sodium hyaluronate;
0.2 part of plant essential oil;
1 part of lactic acid;
1.5 parts of carboxymethyl cellulose;
1.2 parts of glycerol;
1.5 parts of a pH regulator;
1 part of an emulsifier;
purified water is complemented to 100 parts;
the plant extract is prepared from the following raw materials in parts by weight:
9 parts of sophora flavescens;
7 parts of phellodendron;
3 parts of fructus cnidii;
5 parts of salvia miltiorrhiza;
4 parts of safflower;
6 parts of motherwort;
and 2 parts of folium artemisiae argyi.
7. The method for preparing the nourishing and bacteriostasis gel according to any one of the claims 1 to 6, which is characterized in that: the method comprises the following steps:
step one, adding a proper amount of purified water into lactic acid, and dissolving to obtain a lactic acid solution;
step two, crushing radix sophorae flavescentis, golden cypress, fructus cnidii, salvia miltiorrhiza, safflower, motherwort and folium artemisiae argyi into coarse powder, and extracting by using a percolation method to obtain a plant extract;
dissolving carboxymethyl cellulose, bioactive peptide, active polysaccharide and sodium hyaluronate in a proper amount of purified water, standing for 10-12 hours to fully swell the carboxymethyl cellulose, and uniformly stirring to obtain a gel matrix;
step four, diluting the plant essential oil and the glycerol with a proper amount of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;
and step five, adding the lactic acid solution, the plant extract and the essential oil mixture into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator under a stirring state until the pH is 4-6, and uniformly stirring to obtain the gel.
8. The method for preparing the nourishing and bacteriostasis gel according to claim 7, wherein the gel comprises the following steps: the second step specifically comprises: pulverizing radix Sophorae Flavescentis, cortex Phellodendri, fructus Cnidii, Saviae Miltiorrhizae radix, Carthami flos, herba Leonuri, and folium Artemisiae Argyi into coarse powder, extracting by percolation, soaking in 55% ethanol for 5-7 days, slowly percolating, soaking for 3-5 days, slowly percolating, squeezing the residue, mixing percolates for 2 times, decolorizing with active carbon, recovering ethanol, standing for more than 24 hr, recovering ethanol, and concentrating to relative density of 1.08-1.10 at 60 deg.C to obtain plant extract.
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| CN115252511A (en) * | 2022-09-29 | 2022-11-01 | 美尚(广州)化妆品股份有限公司 | Sunscreen composition with gel network structure and preparation method thereof |
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