CN107789277A - A kind of hyaluronic acid lip composition and preparation method with multi-efficiency - Google Patents
A kind of hyaluronic acid lip composition and preparation method with multi-efficiency Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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Abstract
The present invention provides a kind of hyaluronic acid lip composition with multi-efficiency, said composition including following weight than component：Hyaluronic acid 0.01 5.0%, plant regulation agent 0.5 5.0%, function thing 0.2 1.0%, matrix auxiliary material 89.0 99.3%, wherein, the golden flower of plant regulation agent hundred, the wind-weed, dragon tree and sucrose composition are formulated；The function thing is made up of polyglutamic acid, collagen, allantoin to be formulated.Include lipstick by adding hyaluronic acid cosmetic lip products made of related matrix auxiliary material, also including but not limited to lipstick, lip honey, lip gloss, lip glaze, Transparent lipstick, lip brightener, lip care ointment, lip care face cream, lip liner etc..
Description
Technical field
The present invention relates to beauty filed of daily-use chemical industry, more particularly to a kind of hyaluronic acid lip combination with multi-efficiency
Thing and preparation method.
Background technology
Lipstick, lipstick, lip honey etc. are to make lip ruddy glossy, reach moist, protection lip, increase facial aesthetic feeling and repair
Positive lip outline has the indispensable cosmetics of a kind of product for the effect of setting off, especially women, can show glamour, the property of women
Sense and confidence.
The lip of the mankind is made up of skin, musculus orbicularis oris and mucous membrane, can be divided into skin portion, red lip and membranous part.It is red
Lip is the main portions of cosmetic lip cosmetics effect, when it is that lip gently closes, the crimson color lip seen by front, and red lip
Portion is very thin, and without cuticula and pigment, so can pass through blood color in blood vessel forms red lip, its moistening is entirely by local abundant
Capillary and a small amount of undergrown sebaceous glands maintain, and everyone red labial surface product and thickness are not quite similar, institute
The red lip volume formed is that the plentiful degree of red lip also differs, wherein the plentiful degree of red lip directly affects the outward appearance of whole lip.By
This is visible, and red lip is not only very fragile to be needed to protect, it is also necessary to is maintained its wettability and plentiful degree for a long time, can be shown proud
Glamour.It is reported that mostly there is the phenomenon of lip drying peeling commonly using the crowd of cosmetic lip cosmetics, because one
As product in the pigment that contains, chemical matrix can absorb moisture in lip mucomembranous cell so that lip mucomembranous cell occurs
Dehydrating phenomena so that lip becomes to dry corrugation, severe patient can also microbiological contamination, infection, inflammation, swelling etc., cause user's body and mind
With more grievous hurts of body.Because the use of cosmetic lip cosmetics is in lip, inevitably it is swallowed in mouth, in general production
Product can containing some harmful materials, accumulate over a long period under, the harmful substance swallowed among human body will necessarily be to body
Health produce harm.But as the fashion cosmetics of a kind of main flow, cosmetic lip cosmetics are that people seeking beauty can not forget.
Therefore, a kind of safer practicality of exploitation, lasting stability, the cosmetic lip products of multi-efficiency are particularly urgent.
The content of the invention
To solve the technical problem of existing lipstick product, a kind of safer practicality, lasting stability, the lip of multi-efficiency
Cosmetics.
What the first technical scheme provided by the invention was realized in：
A kind of hyaluronic acid lip composition, said composition include following weight than component：
Wherein, plant regulation agent is made up of hundred golden flower, the wind-weed, dragon tree and sucrose and is formulated；The function thing is by gathering
Glutamic acid, collagen, allantoin composition are formulated.
Further, hundred golden flower, the wind-weed, dragon tree and the sucrose 3-5 in mass ratio in plant regulation agent:1-3:3-5:1-
2 compositions；Preferably, hundred golden flower, the wind-weed, dragon tree and each composition optimum weight ratio 5 of sucrose:1.5:3.5:1.
Further, the polyglutamic acid in function thing, collagen, allantoin 1-3 in mass ratio:1-2:2-3 is formed；It is excellent
Choosing, each composition optimum weight ratio of polyglutamic acid, collagen, allantoin is 1.5:1:2.
Further, by taking hyaluronic acid lipstick as an example, matrix auxiliary material includes olive oil, avocado oil, candelila wax, cohune
Palmitic acid wax, beeswax, alkermes, rapeseed oil, Rosa Damascana, SIMMONDSIA CHINENSIS SEED OIL.
Further, hyaluronic acid lipstick made of the hyaluronic acid lip composition, according to the weight of following composition
Than composition, hyaluronic acid 0.01-5.0%, plant regulation agent 0.5-5.0%, function thing 0.2-1.0%, olive oil 20.0%, crocodile
Pear oil 20.0%, candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil
5.0%th, Rosa Damascana 3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL are mended to 100.
What second of technical scheme provided by the invention was realized in：
The preparation method of hyaluronic acid lip composition, it is characterised in that comprise the following steps：
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in 50g's in 35-40 DEG C
In 1.0% sodium chloride solution, 1000-3000r/min stirring digestion 3-4h, PH5.0-5.6 is adjusted, adds deionized water to mix to 100g
Close uniformly, be prepared into hyaluronic acid solution of the concentration range in 4.5%-9.0%, save backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 3-5:1-3:3-5:1-2 forms plant regulation agent, wherein
Each composition optimum weight ratio 5:1.5:3.5:1 weighs rear co-grinding into 1000 grams of coarse powder, adds 10 times of amount water, boiling 2 hours, mistake
Filter is handled, and filter residue adds 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue adds the water of 8 times of amounts, boiling 1 hour, at filtering again
Reason, filtrate merge, be concentrated under reduced pressure at 50 DEG C relative density be 1.0g/ml clear cream, in use, plus ethanol reach alcohol content
60%, 24 hours are stood, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby；
C, polyglutamic acid, collagen, allantoin 1-3 in mass ratio:1-2:2-3 composition function things, optimum weight ratio
1.5:1:2 weigh polyglutamic acid, collagen and allantoin respectively, are well mixed, as function thing, standby；
D, function thing is taken to add in hyaluronic acid solution, 30-50 DEG C of temperature control stirs under 1000-2000r/min
20nim, it is stirring evenly and then adding into plant regulation agent and is ultrasonically treated 20-50min under 60-80HZ so that solution is well mixed, spray
Mist is dried to dry powder, as composition dry powder, standby；
E, above-mentioned composition dry powder is slowly added into and configures the material body for cooling to 50-55 DEG C with matrix auxiliary material in advance
In, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
Hyaluronic acid lip composition of the present invention：Different quality percentage is pressed by hyaluronic acid, plant regulation agent, function thing
Composition, adds related matrix auxiliary material and makes hyaluronic acid cosmetic lip products, such as lipstick.Key component each the effect of, phase
Mutual synergetical principle and advantage are as follows：
1st, natural plant regulation agent is condensed into clear cream, work of the active component therein in sucrose molecule in sucrose solution
With lower tight clusters, infiltration together, can efficiently suppress or kill Candida albicans, staphylococcus aureus, large intestine bar
The bacteriums such as bacterium, Pseudomonas aeruginosa and fungi, so as to reduce as the skin of lip mucosa infection and the hair of inflammatory reaction caused by them
It is raw；Active ingredient in plant regulation agent simultaneously can also rapidly enter skin in the presence of sucrose molecule and hyaluronic acid,
So as to promote skin of lip mucous membrane to secrete functional component, and then suppress the inflammatory stimulus effect of inflammation and anti-endotoxin, reach
Strengthen the effect of skin of lip mucosa-immune power；Plant regulation agent includes chlorogenic acid, saponin(e, thaspine, former cyanine, plant steroid
The plurality of active ingredients such as alcohol can adjust sebum secretion, remove free radical, stimulation of releiving, repair damage, with reference to hyaluronic acid, gather
The compositions such as glutamic acid, collagen and allantoin can make skin of lip reach more preferably state, according to efficacy test knot
Fruit show they in replenishing water and preserving moisture, calmness releive, anti-inflammatory reparation and lubrication is plentiful etc. reaches synergy；It is certain density
Sucrose clear cream has osmosis, while the sucrose clear cream of high concentration can also suppress harmful microbe growth, prevent lip skin
Skin infects and the generation of secondary inflammation.
2nd, each composition in function thing is adjusted after certain proportion and method complex treatment obtain with reference to hyaluronic acid and plant
Manage agent use can abundant replenishing water and preserving moisture, wherein polyglutamic acid and hyaluronic acid intramolecular water lock can be promoted to act on each other so that
There is excellent chemiluminescence in terms of replenishing water and preserving moisture, lip can be prevented with the maintenance skin of lip wettability of high-efficient and lasting
Portion's chapped skin peeling；The effect of micromolecular collagen collaboration hyaluronic acid and sucrose molecule can also promote dermal collagen egg
The content of polysaccharide is sticked in white and regulation corium, maintenance conditioning is carried out from skin of lip deep layer, smooths microgroove, lubricate plentiful lip skin
Skin surface, reach the purpose of long-acting plentiful lip；Active ingredient in the plant regulation agent of allantoin collaboration simultaneously can also promote
Skin of lip anti-inflammatory, antiallergy are helped, releives and promotes cell repair, the anti-irritant ability of skin of lip can be improved, maintained
The optimal health status of lip skin.
3rd, the hyaluronic acid also known as Hyaluronic Acid in the present invention, is a kind of high molecular polymer, by unit D-Glucose aldehyde
The advanced acid mucopolysaccharide of acid and N-acetyl-glucosamine composition, it is the tender important foundation material of skin water, itself is also human body
A kind of composition, it has special water retention, and deal is more up to 100 times of itself weight, is the nature having now been found that
The best material of moisture retention in boundary.Hyaluronic acid is applied in product of the present invention through special process processing can be in skin of lip table
Face forms a tunic, prevents the evaporation of lip skin internal moisture；Simultaneously micromolecule hyaluronic acid can rapid osmotic lip skin, wink
Shi Suoshui, moisturizing；Long-term use of lipstick containing hyaluronic acid is remarkably improved skin of lip moisture, lip skin water is moistened light
Pool, skin of lip Nutrition and Metabolism can also be improved, make skin of lip it is tender, it is smooth, go to wrinkle, increase elasticity, prevent aging；Protecting
It is good skin penetration enhancer again while wet, is used cooperatively with other nutritional ingredients, promotion nutrient absorption can be played
More preferable effect.
4th, composition containing hyaluronic acid, function thing and plant regulation agent using its moisturizing of skin of lip, antiallergic,
Anti-inflammatory, antibacterial, reparation, the effect of plump aspect, are made up by adding hyaluronic acid cosmetic lip made of related matrix auxiliary material
The basic function that not only there is product mill run to moisten, be bright, beautification lip, not de- adornment do not fade, also with moisturizing it is plentiful, disappear
Scorching antibacterial, antiallergic repairs the multi-efficiencies such as lip, is a safe and practical, lasting stability, the novel transparent matter of multi-efficiency acid
Cosmetic lip products.The novel transparent matter acid cosmetic lip products include lipstick, also including but not limited to lipstick, lip honey, lip gloss,
Lip glaze, Transparent lipstick, lip brightener, lip care ointment, lip care face cream, lip liner etc..
Embodiment
To describe the technology contents of the present invention, construction feature, the objects and the effects in detail, below in conjunction with embodiment
It is explained.
1. plan content
1.1.1 hyaluronic acid lipstick formula (part by weight)
Hyaluronic acid 1.0%, plant regulation agent 2.5%, function thing 0.5%, olive oil 20.0%, avocado oil 20.0%,
Candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana
3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL is mended to 100.
Above-mentioned each constituent is described in detail as follows：
(1) hyaluronic acid
Hyaluronic acid also known as Hyaluronic Acid, it is a kind of high molecular polymer, by unit D-Glucose aldehydic acid and N- acetyl Portugal
The advanced acid mucopolysaccharide of osamine composition, it is the tender important foundation material of skin water, itself is also a kind of composition of human body, it
With special water retention, deal is more up to 100 times of itself weight, is that moisture retention is best in the nature having now been found that
Material.Hyaluronic acid is handled through special process to be applied in product of the present invention and can form a tunic on skin of lip surface,
Prevent the evaporation of lip skin internal moisture；Simultaneously micromolecule hyaluronic acid can rapid osmotic lip skin, instantaneous water lock, moisturizing；
Long-term use of lipstick containing hyaluronic acid is remarkably improved skin of lip moisture, lip skin water is moistened gloss, can also change
Kind skin of lip Nutrition and Metabolism, make skin of lip it is tender, it is smooth, go to wrinkle, increase it is elastic, prevent aging；While moisturizing again
It is good skin penetration enhancer, is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played
Fruit.
(2) plant regulation agent
Mixed according to a certain percentage in sucrose solution by hundred golden flower, three kinds of wind-weed, dragon tree active plants, be condensed into it is clear
Cream, then gained is extracted, the active ingredient in the active plant conditioner has obvious antibacterial, anti-inflammatory, oxidation resistant effect, knot
Deep layer reparation and conditioning lip skin can be haveed the function that by closing other active ingredients in formula.
Hundred golden flower：Hundred golden flower extracts mainly contain chlorogenic acid, bitter principle, alkaloid, phytosterol and other functional ingredient, right
Hay bacillus, Escherichia coli, Pseudomonas aeruginosa and staphylococcus aureus etc. have extensive bacteriostasis；To elastin laminin enzyme activity
Property strong inhibition effect display, the extract can slow down the degraded of elastin laminin, be advantageous to maintain skin of lip elasticity；This is carried
It can also be that lip skin keeps the skin wet to take thing, the skin being easily dried of releiving.Mainly suppress lip in hyaluronic acid lipstick
Portion's courses of infection and trigger inflammatory reaction, while can with deep layer reparation and conditioning lip skin, make the plentiful high resilience of lip.
The wind-weed：Main active saponin(e that the wind-weed contains, double benzene pyrrones etc. have certain suppression to a variety of viral germs
System and killing action, as Escherichia coli, Pseudomonas aeruginosa, Candida albicans and staphylococcus aureus, particularly popularity pass
The virus and bacteria of dye disease has good killing effect；Show that there is anti-inflammatory, can use to the inhibitory action of leukocyte cell
In the preventing and treating and generation of dermatitis.Mainly suppress lip courses of infection in hyaluronic acid lipstick and trigger inflammatory reaction, simultaneously
Have the function that to resist skin of lip inflammation.
Dragon tree：Dragon tree extract contains thaspine (Taspine) and former cyanine (PAC).Thaspine has very
Strong inoxidizability, can also strengthen skin of lip stratum corneum barrier, and repair the lip caused by inherent and outside cause it is obscure,
The problems such as lip colour of skin inequality and lip microgroove；OPC is the maximally effective day of current internationally recognized removing human free radical
Right antioxidant, it potent resistance inflammation and can repair damage, while establish lip skin moisture barrier, improve red blood silk and
It is sensitive.Antioxidant, antiinflammatory, skin of lip conditioner is mainly done in hyaluronic acid lipstick to use.
Sucrose：Sucrose is the small molecule wetting agent that content is high in beet, sugarcane and fruit, has good moisturizing to make
With certain density sucrose solution has osmosis, and active ingredient can be promoted to rapidly enter skin of lip and play effect and make
With, while the sucrose solution of high concentration can also suppress harmful microbe growth.It is mainly moisturizing in hyaluronic acid lipstick, promotees
Ooze, antibacterial effect.
(3) function thing
Arranged in pairs or groups and used with method according to a certain percentage by polyglutamic acid, collagen and allantoin, with reference to hyaluronic acid not
Only there is certain collaboration moisture retention, can also effectively reduce sensitization rate, deep layer reparation and nourishing lip skin, make lips plentiful
Moving, playing wind and stringing instruments to break.
Polyglutamic acid：It is reported that polyglutamic acid (γ-PGA) is a kind of water-soluble, biodegradable, use without toxicity
Boiomacromolecule made from microbe fermentation method, it is a kind of sticking material, is found first in " natto ".γ-PGA
It is a kind of special anion nature polymer, is using the glutamic acid of left and right optical activity as cell cube, in alpha-amido and γ-carboxylic
Formed homotype polyamide polypeptide is bonded between base through acid amides, γ-PGA molecular weight is from 5 ten thousand to 2 megadaltons.
Special molecular structure, extremely strong moisture-retaining capacity is made it have, can effectively increase the moisture-retaining capacity of skin of lip, promote lip
Skin health, its superpower moisture-retaining capacity are better than common moisturizing ingredient, for the biotechnology NMF of a new generation.
Collagen：Collagen is efficient moisturizing composition, can be human body connective group with skin-active, inducing tissue regeneration
Main bonding material among knitting, its molecular weight is big, moisture-retaining capacity compared with polyalcohols more preferably, mainly to support cell, especially
Skin of lip and skin of lip suitable for no cutin are in the physiotherapy guarantee made in the most thin stage.Collagen also has
Good permeability, hydrolysate compatibility is strong, the effect of can coordinating with many functional components to improve them.
Allantoin：It is main to do skin of lip conditioner, protective agent use, it is good NMF, allantoin can reduce angle
The adhesion strength of matter confluent monolayer cells, keratin can be softened, accelerate epidermal cell renewal, additionally it is possible to help skin of lip anti-inflammatory, releive
And promote cell repair, stimulation can be mitigated, while have antioxidation.
(4) matrix auxiliary material
By taking lipstick as an example, preferably SIMMONDSIA CHINENSIS SEED OIL, avocado oil, candelila wax, Brazil wax, beeswax, olive oil, cochineal
Red, rapeseed oil, Rosa Damascana, for product figuration and other effects, wherein SIMMONDSIA CHINENSIS SEED OIL is used for the surplus benefit of 100 parts of gross weight
Fill.
1.1.2 the preparation method of hyaluronic acid lip composition
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 35 DEG C
Sodium chloride solution in, 1000 stirring digestion 3h, adjust PH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
5.0% hyaluronic acid solution, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 5:1.5:3.5:1 to weigh rear co-grinding thick into 1000 grams
Powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtration treatment；Filter residue adds 8 times again
The water of amount, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C,
In use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby
With；
C, polyglutamic acid, collagen, allantoin 1.5 in mass ratio:1:2 weigh polyglutamic acid, collagen respectively
With totally 0.5 gram of allantoin, it is well mixed, as function thing, it is standby；
D, 0.5 gram of function thing is taken to add in 20.0 grams of hyaluronic acid solutions, 35 DEG C of temperature control stirs under 1200r/min
20nim, it is stirring evenly and then adding into 2.5 grams of plant regulation agent and is ultrasonically treated 25min under 65HZ so that solution is well mixed, spray
Mist is dried to dry powder, as composition dry powder, standby；
E, the matrix auxiliary material includes olive oil, avocado oil, candelila wax, Brazil wax, beeswax, alkermes, dish
Seed oil, Rosa Damascana, SIMMONDSIA CHINENSIS SEED OIL, and be configured to expect body；Above-mentioned composition dry powder is slowly added into this to be pre-configured with, cool
Into 50-55 DEG C of matrix auxiliary material material body, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains
Bright matter acid lipstick.
1.2.1 hyaluronic acid lipstick formula (part by weight)
Hyaluronic acid 2.0%, plant regulation agent 0.5%, function thing 1.0%, olive oil 20.0%, avocado oil 20.0%,
Candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana
3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL is mended to 100.
1.2.2 the preparation method of hyaluronic acid lip composition
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 38 DEG C
Sodium chloride solution in, 1500 stirring digestion 3.4h, adjust PH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
6.0% hyaluronic acid solution, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 5:1.5:3.5:1 to weigh rear co-grinding thick into 1000 grams
Powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtration treatment；Filter residue adds 8 times again
The water of amount, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C,
In use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby
With；
C, polyglutamic acid, collagen, allantoin 1.5 in mass ratio:1:2 weigh polyglutamic acid, collagen respectively
With totally 1.0 grams of allantoin, it is well mixed, as function thing, it is standby；
D, 1.0 grams of function things are taken to add in 33.0 grams of hyaluronic acid solutions, 40 DEG C of temperature control stirs under 1600r/min
20nim, it is stirring evenly and then adding into 0.5 gram of plant regulation agent and is ultrasonically treated 30min under 70HZ so that solution is well mixed, spray
Mist is dried to dry powder, as composition dry powder, standby；
E, above-mentioned composition dry powder is slowly added into and configures the material body for cooling to 50-55 DEG C with matrix auxiliary material in advance
In, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
1.3.1 hyaluronic acid lipstick formula (part by weight)
Hyaluronic acid 0.1%, plant regulation agent 5.0%, function thing 0.2%, olive oil 20.0%, avocado oil 20.0%,
Candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana
3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL is mended to 100.
1.3.2 the preparation method of hyaluronic acid lip composition
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 38 DEG C
Sodium chloride solution in, 1500 stirring digestion 3.4h, adjust PH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
6.0% hyaluronic acid solution, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 5:1.5:3.5:1 to weigh rear co-grinding thick into 1000 grams
Powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtration treatment；Filter residue adds 8 times again
The water of amount, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C,
In use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby
With；
C, polyglutamic acid, collagen, allantoin 1.5 in mass ratio:1:2 weigh polyglutamic acid, collagen respectively
With totally 0.2 gram of allantoin, it is well mixed, as function thing, it is standby；
D, 0.2 gram of function thing is taken to add in 1.65 grams of hyaluronic acid solutions, 40 DEG C of temperature control stirs under 1200r/min
20nim, it is stirring evenly and then adding into 5.0 grams of plant regulation agent and is ultrasonically treated 50min under 80HZ so that solution is well mixed, spray
Mist is dried to dry powder, as composition dry powder, standby；
E, above-mentioned composition dry powder is slowly added into and configures the material body for cooling to 50-55 DEG C with matrix auxiliary material in advance
In, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
1.4.1 hyaluronic acid lipstick formula (part by weight)
Hyaluronic acid 1.0%, plant regulation agent 3.0%, function thing 0.8%, olive oil 20.0%, avocado oil 20.0%,
Candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana
3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL is mended to 100.
1.4.2 the preparation method of hyaluronic acid lip composition
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 40 DEG C
Sodium chloride solution in, 2000 stirring digestion 3.8h, adjust PH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
8.0% hyaluronic acid solution, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 5:1.5:3.5:1 to weigh rear co-grinding thick into 1000 grams
Powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtration treatment；Filter residue adds 8 times again
The water of amount, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C,
In use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby
With；
C, polyglutamic acid, collagen, allantoin 1.5 in mass ratio:1:2 weigh polyglutamic acid, collagen respectively
With totally 0.8 gram of allantoin, it is well mixed, as function thing, it is standby；
D, 0.8 gram of function thing is taken to add in 12.5 grams of hyaluronic acid solutions, 45 DEG C of temperature control stirs under 1600r/min
20nim, it is stirring evenly and then adding into 3.0 grams of plant regulation agent and is ultrasonically treated 45min under 65HZ so that solution is well mixed, spray
Mist is dried to dry powder, as composition dry powder, standby；
E, above-mentioned composition dry powder is slowly added into and configures the material body for cooling to 50-55 DEG C with matrix auxiliary material in advance
In, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
1.5.1 hyaluronic acid lipstick formula (part by weight)
Hyaluronic acid 1.5%, plant regulation agent 4.0%, function thing 0.5%, olive oil 20.0%, avocado oil 20.0%,
Candelila wax 10.0%, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana
3.5%, surplus SIMMONDSIA CHINENSIS SEED OIL is mended to 100.
1.5.2 the preparation method of hyaluronic acid lip composition
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 35 DEG C
Sodium chloride solution in, 2500 stirring digestion 4.0h, adjust PH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
8.0% hyaluronic acid solution, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 5:1.5:3.5:1 to weigh rear co-grinding thick into 1000 grams
Powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtration treatment；Filter residue adds 8 times again
The water of amount, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C,
In use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby
With；
C, polyglutamic acid, collagen, allantoin 1.5 in mass ratio:1:2 weigh polyglutamic acid, collagen respectively
With totally 0.5 gram of allantoin, it is well mixed, as function thing, it is standby；
D, 0.5 gram of function thing is taken to add in 18.75 grams of hyaluronic acid solutions, 45 DEG C of temperature control is stirred under 1800r/min
20nim to be mixed, 4.0 grams of plant regulation agent is stirring evenly and then adding into and is ultrasonically treated 50min under 75HZ so that solution is well mixed,
Dry powder, as composition dry powder are spray dried to, it is standby；
E, above-mentioned composition dry powder is slowly added into and configures the material body for cooling to 50-55 DEG C with matrix auxiliary material in advance
In, abundant homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
2. the moisture retention of hyaluronic acid lip composition is tested (by taking hyaluronic acid lipstick as an example)
The instant moisture retention experiment of 2.1 hyaluronic acid lipsticks
The healthy women 20 in 18-50 year the without disease of skin that experimental selection can be influenceed by result of the test completely
Tested for object, to test the instant moistening effect of hyaluronic acid lipstick (each sample formula is as shown in table 1).Specific method
It is as follows：Each experimental subjects is before sample, after first cleaning lip with water, then adapts to external environment condition 30 minutes.The environment bar of experiment
Part is：22-24 DEG C of indoor temperature, indoor humidity 45-50% are kept, and is tested in same place.Applied in the red lip of lip
Sample is smeared, and is dried 1 minute.Then respectively applied again at the position of smearing and spread 20ul ultra-pure water, with after towel moisture with 1
Hour for interval (0 hour, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, it is 10 small
When), moistening effect is measured to the skin surface moisture at each smearing position with Corneometer CM 825.Measurement result
As shown in table 2, unit is Corneometer value (Cv).
The composition composition situation of each sample hyaluronic acid lipstick of table 1 is as follows：
Note："-" represents to be not added with.
The instant moistening effect measurement result of each sample hyaluronic acid lipstick of table 2 is as follows：
Conclusion：
From table 1,2, hyaluronic acid, plant regulation agent and function thing three are applied by certain weight ratio can in lipstick
To dramatically increase the instant moistening effect of lipstick；
From table 1,2, hyaluronic acid, plant regulation agent and function thing three are transparent as made of combining certain weight ratio
Matter acid lipstick is more preferable than the instant moistening effect of lipstick made of single hyaluronic acid, plant regulation agent, function thing, illustrates transparent
Matter acid, plant regulation agent, function thing three combination made of lipstick there is obvious chemiluminescence in terms of moistening effect；
(3) from table 1,2, hyaluronic acid of the mass fraction in the range of 0.1-3.0%, in the range of 0.5-5.0%
Plant regulation agent, in the range of 0.2-1.0% function thing three combination made of hyaluronic acid lipstick in moistening effect side
Face is respectively provided with chemiluminescence；
(4) comparative sample understand, hyaluronic acid, plant regulation agent, function thing three addition be 1.0%, 2.5%,
When 0.5%, the moisturizing chemiluminescence of hyaluronic acid lipstick is most reasonable, inadequate less than this value moistening effect, higher than this
Value moistening effect amplification slows down and the problems such as expecting body waste, cost increase occurs.
(5) by showing the instant moisturizing Journal of Sex Research of hyaluronic acid lipstick, hyaluronic acid lip composition has same
Excellent specific property.
The long-acting moisture retention experiment of 2.2 hyaluronic acid lipsticks
The dry and cracked peeling of the lip of 18-50 year without disease of skin that experimental selection can be influenceed by result of the test completely
20 entitled object of healthy women tested, to test the long-acting guarantor of hyaluronic acid lipstick (each sample formula as shown in table 3)
Wet effect.Specific method is as follows：Each experimental subjects is before sample, after first cleaning lip with water, then adapts to external environment condition 30 and divides
Clock.The environmental condition of experiment is：22-24 DEG C of indoor temperature, indoor humidity 45-50% are kept, and is tested in same place.
Sample is smeared in the red lip of lip, and is dried 1 minute.Then the ultra-pure water for spreading 20ul is respectively applied again at the position of smearing, with hair
Towel dries moisture and is measured guarantor to the skin surface moisture at each smearing position with Corneometer CM 825 after 10 hours
Wet effect.Above experimentation repeats 4 weeks, and measurement result is as shown in table 4, and unit is Corneometer value (Cv).
The composition composition situation of each sample hyaluronic acid lipstick of table 3 is as follows：
| Hyaluronic acid | Plant regulation agent | Function thing | Matrix auxiliary material | |
| Sample 1 | 1.0% | 2.5% | 0.5% | To 100 |
| Sample 2 | 1.0% | 2.5% | - | To 100 |
| Sample 3 | 1.0% | - | 0.5% | To 100 |
| Control group 1 | 1.0% | - | - | To 100 |
| Control group 2 | - | - | - | To 100 |
Note："-" represents to be not added with.
The long-acting moistening effect measurement result of each sample hyaluronic acid lipstick of table 4 is as follows：
| 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks | |
| Sample 1 | 52.6 | 53.7 | 55.2 | 58.7 | 65.4 |
| Sample 2 | 50.9 | 51.1 | 52.0 | 52.6 | 53.4 |
| Sample 3 | 51.5 | 51.8 | 53.0 | 54.7 | 56.8 |
| Control group 1 | 46.3 | 46.5 | 47.5 | 48.4 | 49.6 |
| Control group 2 | 25.1 | 25.0 | 24.8 | 23.5 | 21.2 |
Conclusion：
(1) from table 3,4, hyaluronic acid, plant regulation agent and function thing three addition are 1.0%, 2.5%,
0.5% applies the long-acting moistening effect that lipstick can be dramatically increased in lipstick；
From table 3,4, hyaluronic acid, plant regulation agent and function thing three are transparent as made of combining certain weight ratio
Matter acid lipstick is more preferable than the long-acting moistening effect of lipstick made of single hyaluronic acid, plant regulation agent, function thing, illustrates transparent
Matter acid, plant regulation agent, function thing three combination made of lipstick there is obvious chemiluminescence in terms of moistening effect；
Compared with control group, long-term use of lipstick containing hyaluronic acid, skin of lip moisture has the increase of conspicuousness,
Efficient moisture-retention can be reached and alleviate the effect of the dry and cracked peeling of lip.
(4) by showing the long-acting moisturizing Journal of Sex Research of hyaluronic acid lipstick, hyaluronic acid lip composition has same
Excellent specific property.
3. the hair conditioning of hyaluronic acid lip composition is tested (by taking hyaluronic acid lipstick as an example)
Now using human experimentation method detection hyaluronic acid lipstick human body bioactivity, i.e., antiallergic releive, anti-inflammatory
The activity of conditioning is repaired, nourished, the hyaluronic acid lipstick is studied to prevent and nurse one's health skin of lip discomfort, refers specifically to lip mucous membrane
Cell is dehydrated, and skin of lip becomes to dry corrugation, severe patient's lip can also microbiological contamination, infection, inflammation, swelling, pain etc. no
Suitable phenomenon.
All experimenters of this experiment are different degrees of skin of lip discomfort person, and each sample hyaluronic acid lipstick is into packet
Into as shown in table 5, experimental group 1 combines manufactured mouth using hyaluronic acid 1.0%+ plant regulation agent 2.5%+ functions thing 0.5%
Proof sheet product are smeared 1 time before sleeping every night；Experimental group 2 combines manufactured lipstick using hyaluronic acid 1.0%+ plant regulations agent 2.5%
Sample is smeared 1 time before sleeping every night；It is every that experimental group 3 uses hyaluronic acid 1.0%+ functions thing 0.5% to combine manufactured lipstick sample
Evening smears 1 time before sleeping；Positive control is smeared 1 time before being slept every night using lipstick sample made of hyaluronic acid 1.0%；Negative control
Smeared 1 time before being slept every night using common lipstick；Symptom improves situation after comparing five groups of conditionings 7 days.
The composition composition situation of each experimental group lipstick sample of table 5 is as follows:
| Hyaluronic acid | Plant regulation agent | Function thing | Matrix auxiliary material | |
| Experimental group 1 | 1.0% | 2.5% | 0.5% | To 100 |
| Experimental group 2 | 1.0% | 2.5% | - | To 100 |
| Experimental group 3 | 1.0% | - | 0.5% | To 100 |
| Positive controls | 1.0% | - | - | To 100 |
| Negative control group | - | - | - | To 100 |
Note："-" represents to be not added with.
Lip mucomembranous cell is dehydrated, and skin of lip becomes to dry corrugation, and severe patient's lip can also microbiological contamination, infection, hair
The symptom assessment of the uncomfortable phenomenon such as inflammation, swelling, pain：
It is effective：Symptom is significantly improved or disappeared, experimenter's satisfaction；Effectively：Symptom has improvement or mitigated, and experimenter still has not
It is suitable, it is desirable to continue to nurse one's health；It is invalid：Symptom mitigates without obvious, and experimenter is unsatisfied with.
Statistical method：Statistical procedures are carried out using SPSS12.0 statistics softwares, compared between metering and enumeration data group
Examined compared with being examined using t with x2, with p<0.05 is statistically significant difference.
As a result it is as follows：
As shown in table 6, the 8th day symptom improves situation：Experimental group 1 effective 10, total effective rate 100%；Experimental group 2 is aobvious
Effect 6, effective 1, invalid 3, total effective rate 70%, obvious effective rate P compared with experimental group 1<0.01；Experimental group 3 effective 6,
It is effective 2, invalid, 2, total effective rate 80%, obvious effective rate P compared with experimental group 1<0.01；Effective 1 of positive control, effective 4
Example, invalid 5, total effective rate 50%, obvious effective rate P compared with experimental group 1<0.01.
The 8th day each group experimenter symptom of table 6 improves situation and is compared as follows：
| Group | Sample number | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Experimental group 1 | 10 | 10 | 0 | 0 | 100 |
| Experimental group 2 | 10 | 6 | 1 | 3 | 70 |
| Experimental group 3 | 10 | 6 | 2 | 2 | 80 |
| Positive control | 10 | 1 | 4 | 5 | 50 |
| Negative control | 10 | 0 | 0 | 10 | 0 |
Conclusion：
Experimental group 1 (hyaluronic acid 1.0%+ plant regulation agent 2.5%+ functions thing 0.5% combines manufactured lipstick) is obvious
Than experimental group 2 (manufactured lipstick is combined in hyaluronic acid 1.0%+ plant regulations agent 2.5%), (the hyaluronic acid 1.0%+ of experimental group 3
Function thing 0.5% combines manufactured lipstick), positive control (lipstick made of hyaluronic acid 1.0%) and negative control it is (common
Lipstick) effectively.The hyaluronic acid lipstick human experimentation of the present invention shows (1) hyaluronic acid, plant regulation agent and function thing three
Lipstick is to preventing and nursing one's health skin of lip discomfort significant effect made of person's combination；(2) hyaluronic acid, plant sugarcane conditioner and work(
Can lipstick made of thing three combination antiallergic is releived, anti-inflammatory reparation, nourishes conditioning skin of lip problem and have certain work(in a short time
Effect, permanence operation can be more preferably；(3) hyaluronic acid, plant regulation agent and lipstick made of function thing three combination are preventing
There is obvious chemiluminescence with the uncomfortable aspect of conditioning skin of lip.(4) by hyaluronic acid lipstick in lip hair conditioning
Research show that hyaluronic acid lip composition has same excellent specific property.
4. the biocidal property experiment of hyaluronic acid lip composition
Take Clinical isolation Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans a little, connect respectively
Kind cultivates 18h in broth bouillon at 37 DEG C.(calf serum that 20% is added in Pseudomonas aeruginosa broth bouillon) takes
Each bacterial strain nutrient broth culture of 18h cultures, it is made into bacteria suspension and is used to test.Take sterilizing test tubes 11 respectively, the 1st
Branch adds nutrient broth fluid nutrient medium 9ml, and 2-10 branch adds 5ml, the 11st addition 10ml, separately sampled product solution such as table
1ml shown in 7 adds the 1st test tube, takes 5ml to add the 2nd after well mixed, is diluted to the 10th successively, the 11st is not loaded
Product are as control.Often pipe adds escherichia coli suspension 0.1ml, and 24h is cultivated at a temperature of 37 DEG C, takes out observation bacterial growth feelings
Condition.Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans are the same as above-mentioned Germicidal efficacy growing state.As test tube becomes cloudy, i.e. table
Show bacterial growth, sample is without bacteriostasis；As test tube is limpid, expression bacterial growth is suppressed.Experimental result is as shown in table 8,
The composition solution of hyaluronic acid, plant regulation agent and function thing three is to clinic point in hyaluronic acid lip composition of the present invention
There is stronger bacteriostasis from strain Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans.
The bacteriostatic experiment each sample solution composition of table 7 forms：
| Hyaluronic acid | Plant regulation agent | Function thing | Deionized water | |
| Sample 1 | 1.0% | 2.5% | 0.5% | To 100 |
| Sample 2 | 1.0% | 2.5% | - | To 100 |
| Sample 3 | 1.0% | - | 0.5% | To 100 |
| Sample 4 | - | 2.5% | 0.5% | To 100 |
| Sample 5 | 1.0% | - | - | To 100 |
| Sample 6 | - | 2.5% | - | To 100 |
| Sample 7 | - | - | 0.5% | To 100 |
| Sample 8 | - | - | - | To 100 |
Note："-" represents to be not added with.
The each sample solution of table 8 corresponds to last limpid test tube numbering in bacteriostatic test：
Note："-" represents not limpid.
By above-mentioned limpid broth tubes and control group the transferred species broth agar plates after diluting according to a certain percentage, observation
24h, the Cmin of no bacterial growth is bacteriocidal concentration, is designated as C, unit mg/mL, as a result as shown in table 9, illustrates this hair
Bright hyaluronic acid lip composition is to being clinically separated common Bacteria skin infection strain Escherichia coli, staphylococcus aureus, green pus
Bacillus, Candida albicans have stronger bactericidal action, can effectively suppress the activity of these Bacteria skin infections to prevent and adjust
It is uncomfortable to manage skin of lip；Simultaneously by contrast as can be seen that made of hyaluronic acid, plant regulation agent and function thing three combination
Hyaluronic acid lip composition also has chemiluminescence at antibacterial aspect.
The each sample solution sterilization conditions of table 9：
Note："-" indicates no bactericidal properties.
5. the plentiful lip of hyaluronic acid lip composition is tested (by taking hyaluronic acid lipstick as an example)
Plentiful lip can increase the height of upper lip, lower lip simultaneously, therefore can evaluate the rich of product by calculating lip volume
Be full of lip the effect of.The health of 18-50 year without disease of skin that experimental selection can be influenceed by result of the test completely
20 entitled object of women is tested, and is imitated with testing the plentiful lip of hyaluronic acid lipstick (each sample formula is as shown in table 10)
Fruit.Specific method is as follows：Each experimental subjects is before sample, after first cleaning lip with water, then adapts to external environment condition 30 minutes.It is real
The environmental condition tested is：22-24 DEG C of indoor temperature, indoor humidity 45-50% are kept, and is tested in same place.In lip
The red lip in portion smears sample, and dries 1 minute.Then body is carried out to the lip of each experimenter with the slide calliper rule of precision after 1 hour
Product measure.Above experimentation repeats 4 weeks, and measurement result is as shown in table 11, and unit is cm3.
The composition composition situation of each sample hyaluronic acid lipstick of table 10 is as follows：
| Hyaluronic acid | Plant regulation agent | Function thing | Matrix auxiliary material | |
| Sample 1 | 1.0% | 2.5% | 0.5% | To 100 |
| Sample 2 | 1.0% | 2.5% | - | To 100 |
| Sample 3 | 1.0% | - | 0.5% | To 100 |
| Control group 1 | 1.0% | - | - | To 100 |
| Control group 2 | - | - | - | To 100 |
Note："-" represents to be not added with.
The plentiful lip effect measuring result of each sample hyaluronic acid lipstick of table 11 is as follows：
| 0 hour | 1 hour | 1 week | 2 weeks | 3 weeks | 4 weeks | |
| Sample 1 | 1.22 | 1.36 | 1.39 | 1.42 | 1.44 | 1.45 |
| Sample 2 | 1.19 | 1.31 | 1.33 | 1.35 | 1.37 | 1.38 |
| Sample 3 | 1.23 | 1.33 | 1.35 | 1.37 | 1.38 | 1.39 |
| Control group 1 | 1.25 | 1.30 | 1.31 | 1.31 | 1.31 | 1.32 |
| Control group 2 | 1.21 | 1.23 | 1.24 | 1.25 | 1.25 | 1.25 |
As shown in Table 11, using hyaluronic acid lipstick 1 made of hyaluronic acid, plant regulation agent, function thing three combination
After hour, experimenter's lip volume significantly increases, and illustrates that hyaluronic acid lipstick of the present invention can plentiful lip in time；Continuous use 4
Zhou Hou, experimenter's lip volume about increase by 15.0%, illustrate that hyaluronic acid lipstick of the present invention can lasting rich lip；By to hyalomitome
The plentiful lip Journal of Sex Research of sour lipstick shows that hyaluronic acid lip composition has same excellent specific property.
6. the acute oral toxicity experiment of hyaluronic acid lip composition
According to test basis《Disinfection technology standard》(defend method prison hair in the 3.4 of (third edition) first fascicle experimental technique specification
[1999] No. 448).By animal (regular grade NIH mouse 20, male and female half and half, 18~22g of body weight) water supply fasting 12 hours,
Distilled water is solvent, and (hyaluronic acid 1.0%+ plant regulation agent 2.5%+ functions thing 0.5% combines manufactured hyalomitome to tested material
Sour lip composition) dosage is set as 5500mg/kg, tested material is once filled to animal with gavage syringe needle by 0.2ml/20g body weight.
Observed immediately after administration and record the poisoning manifestations, death toll and death time of animal, observe secondary, two weeks observation periods daily.
Toxicity grading is carried out according to acute toxicity grading criteria.Experimental result：In observation period, test mice does not occur manifest symptom, nothing
Death occurs.
The tested material of table 15 is to NIH chmice acute Oral toxicity result of the tests
Conclusion：Hyaluronic acid lip composition of the present invention is to the acute through LD50 ＞ 5000mg/kg, true border of NIH mouse
Nontoxic level.
Embodiments of the invention are the foregoing is only, not thereby limit the scope of patent protection of the present invention, every utilization
The equivalent structure or equivalent flow conversion that present specification is made, or directly or indirectly it is used in other related technologies
Field, it is included within the scope of the present invention.
Claims (10)
1. a kind of hyaluronic acid lip composition with multi-efficiency, said composition include following weight than component：
Wherein, the golden flower of plant regulation agent hundred, the wind-weed, dragon tree and sucrose composition are formulated；The function thing by polyglutamic acid,
Collagen, allantoin composition are formulated.
2. hyaluronic acid lip composition as claimed in claim 1, it is characterised in that hundred gold medals in the plant regulation agent
Flower, the wind-weed, dragon tree and sucrose 3-5 in mass ratio:1-3:3-5:1-2 is formed.
3. hyaluronic acid lip composition as claimed in claim 2, it is characterised in that the plant regulation agent is as follows
System is matched somebody with somebody：Hundred golden flower, the wind-weed, dragon tree and each weight ratio of constituents 5 of sucrose in the plant regulation agent:1.5:3.5:1；By this ratio
Example weighs rear co-grinding into 1000 grams of coarse powder, adds 10 times of amount water, boiling 2 hours, filtration treatment, and filter residue adds 8 times of amount water, boiling
1 hour, filtration treatment；Filter residue adds the water of 8 times of amounts again, boiling 1 hour, filtration treatment, filtrate merging, is concentrated under reduced pressure at 50 DEG C
To the clear cream that relative density is 1.0g/ml, in use, plus ethanol make alcohol content up to 60%, stand 24 hours, filtering, filtrate subtracts
Push back receipts ethanol and be concentrated into no alcohol taste.
4. hyaluronic acid lip composition as claimed in claim 1, it is characterised in that polyglutamic acid in the function thing,
Collagen, allantoin 1-3 in mass ratio:1-2:2-3 is formed.
5. hyaluronic acid lip composition as claimed in claim 4, it is characterised in that polyglutamic acid in the function thing,
Each composition optimum weight ratio of collagen, allantoin is 1.5:1:2.
6. hyaluronic acid lip composition as claimed in claim 1, it is characterised in that the matrix auxiliary material is with hyaluronic acid mouth
Include olive oil, avocado oil, candelila wax, Brazil wax, beeswax, alkermes, rapeseed oil, Rosa Damascana, lotus exemplified by red
Lotus bar oil.
7. the hyaluronic acid lip composition as described in claim 1-6 is any, it is characterised in that the hyaluronic acid lip group
Compound adding ingredient system is with being hyaluronic acid lipstick, and the lipstick is according to the weight of following composition than composition, hyaluronic acid 0.01-
5.0%th, plant regulation agent 0.5-5.0%, function thing 0.2-1.0%, olive oil 20.0%, avocado oil 20.0%, candelila wax
10.0%th, Brazil wax 12.5%, beeswax 10.5%, alkermes 3.0%, rapeseed oil 5.0%, Rosa Damascana 3.5%, it is remaining
SIMMONDSIA CHINENSIS SEED OIL is measured to mend to 100.
8. the preparation method of hyaluronic acid lip composition, it is characterised in that comprise the following steps：
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in 35-40 DEG C the 1.0% of 50g
In sodium chloride solution, 1000-3000r/min stirring digestion 3-4h, pH5.0-5.6 is adjusted, adds deionized water to be well mixed to 100g,
Hyaluronic acid solution of the concentration range in 4.5%-9.0% is prepared into, is saved backup；
B, hundred golden flower in mass ratio, the wind-weed, dragon tree and sucrose 3-5:1-3:3-5:1-2 forms plant regulation agent, is mixed after weighing
Conjunction is ground into 1000 grams of coarse powder, add 10 times amount water, boiling 2 hours, filtration treatment, filter residue add 8 times amount water, boiling 1 hour, filtering
Processing；Filter residue adds the water of 8 times of amounts again, boiling 1 hour, filtration treatment, filtrate merging, relative density is concentrated under reduced pressure at 50 DEG C
For 1.0g/ml clear cream, in use, plus ethanol alcohol content is stood 24 hours up to 60%, filtering, decompression filtrate recycling ethanol
And no alcohol taste is concentrated into, it is standby；
C, polyglutamic acid, collagen, allantoin 1-3 in mass ratio:1-2:2-3 composition function things, and poly- paddy is weighed respectively
Propylhomoserin, collagen and allantoin, it is well mixed, as function thing, it is standby；
D, function thing is taken to add in hyaluronic acid solution, 30-50 DEG C of temperature control stirs 20nim under 1000-2000r/min,
It is stirring evenly and then adding into plant regulation agent and is ultrasonically treated 20-50min under 60-80HZ so that solution is well mixed, spray drying
It is standby into dry powder, as composition dry powder；
E, above-mentioned composition dry powder is slowly added into and configured in advance with matrix auxiliary material in the material body for cooling to 50-55 DEG C, filled
Divide homogeneous, stir and pour into mould, after being cooled to room temperature, the demoulding obtains hyaluronic acid lipstick.
9. the preparation method of hyaluronic acid lip composition as claimed in claim 8, it is characterised in that the plant regulation agent
In hundred golden flower, the wind-weed, dragon tree and each composition optimum weight ratio 5 of sucrose:1.5:3.5:1；Polyglutamic in the function thing
Each composition optimum weight ratio of acid, collagen, allantoin is 1.5:1:2.
10. the preparation method of hyaluronic acid lip composition as claimed in claim 8, it is characterised in that the hyaluronic acid
The matrix auxiliary material of lipstick includes olive oil, avocado oil, candelila wax, Brazil wax, beeswax, alkermes, rapeseed oil, rose
Essential oil, SIMMONDSIA CHINENSIS SEED OIL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN108542821A (en) * | 2018-05-28 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | Pregnant line remediation composition and application |
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| CN108542821A (en) * | 2018-05-28 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | Pregnant line remediation composition and application |
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