CN110192996A - A kind of viola mandshurica moisturizer and preparation method thereof and the moisturizing moisturizing sleep mask containing the moisturizer - Google Patents
A kind of viola mandshurica moisturizer and preparation method thereof and the moisturizing moisturizing sleep mask containing the moisturizer Download PDFInfo
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- CN110192996A CN110192996A CN201910568807.8A CN201910568807A CN110192996A CN 110192996 A CN110192996 A CN 110192996A CN 201910568807 A CN201910568807 A CN 201910568807A CN 110192996 A CN110192996 A CN 110192996A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a kind of viola mandshurica moisturizer and preparation method thereof and the moisturizing moisturizing sleep mask containing the moisturizer, the method is with the production of Herba Violae extract moisturizing moisturizing sleep mask as main component.It is prepared from the following raw materials: viola mandshurica moisturizer, thickening polymer, trehalose, micromolecule hyaluronic acid sodium, 1,3 butanediols, preservative and deionized water.Moisturizing moisturizing sleep mask provided by the invention containing Herba Violae extract, there is good moistening effect to skin, and it is additive-free, safe and non-stimulating, not only moistening effect is good compared with existing moisturizing moisturizing sleep mask, and has good water lock effect, manufacture craft is simple, and used Herba Violae extract natural bioactive is high, also with antibacterial, anti-oxidant effect waited.
Description
Technical field
The invention belongs to the technical fields of skin care item, and in particular to a kind of viola mandshurica moisturizer and preparation method thereof with contain
The moisturizing moisturizing sleep mask of the moisturizer.
Background technique
Facial mask is a classification in skin care item.Its most basic and most important purpose is to make up makeup removing and wash one's face still
Right insufficient cleaning cooperates other essential ingredients to realize other maintenance functions, such as replenishing water and preserving moisture, beauty on this basis
White, anti-aging, Sage Extract etc..The principle of facial mask is to be temporarily isolating extraneous sky using the of short duration time for being covered on face
Gas and it is dustless improve skin temperature, the capillary bore expansion of skin promotes sweat gland secretion and metabolism, skin is made to exclude surface
The product of cell metabolism.Moisture in facial mask penetrates into the cuticula of skin epidermis, makes skin that lasting natural light be kept to have
Elasticity, therefore, facial mask gain great popularity in schoolgirl's cosmetology.Presently commercially available facial mask is dazzling, but most products
Middle lead, mercury, benzene, phenol content are exceeded, although can temporarily make skin that glossy soft state be presented, long-time service can make cuticula
It falls off thinning, leads to red swelling of the skin, form color spot, allergy sexual stimulus is caused to skin, long-time service can injure skin, be unfavorable for
Skin health.
The youth being getting faster in face of present work rhythm, in order to adapt to its biological clock, disposable sleep mask meet the tendency of and
It is raw, it is not only easy to use, and than facial mask subsidize water effect it is more preferable (mounted facial mask using needing to remove after about 15 minutes, because
For meeting back suction face moisture after face paper moisture loss), sleep mask is just without this worry.Sleep mask can also effectively releive
It is battle-weary and promote sleep quality, to advantageously promote skin in the metabolism at night, therefore big popular among women.It is special
It is not the sleep mask of good absorbing, makes entire skin full, it is in high spirits.Its principle is exactly to utilize a thick layer of essence dressing,
Contact of the facial skin with air is obstructed, the evaporation of skin moisture is obstructed, increases the humidity of cuticula, cutin-softening；Epidermis temperature
Degree increases to expand pore, is conducive to nutritional ingredient and is smoothly absorbed.Blood circulation is accelerated after skin temperature rises, and makes to seep
Enter the nutrient of skin and broadly spread apart iuntercellular is deeper, quickly supplements the nutrients；Those moisture that can not evaporate of skin surface
Epidermis can be then deposited in, the moisture of epidermis is full, skin seem will smoother it is tight, microgroove can also become
It is light, while fairness, brightness are obviously improved.
The most important effect of its facial mask is exactly moisturizing, and moisturizing is the key that skin nursing, and moisture-retention function of skin decline can be led
A variety of skin problems are caused, and moisture-keeping system natural in normal and flexible skin and human skin has close pass
System.Due to the growth at age and the influence of external environment, the moisturizing mechanism of skin is damaged, skin tissue cell and iuntercellular
Moisture content reduce, cause cell arrangement close, collagen dehydration hardening, when moisture drops to 10% or less in cuticula
When, skin, which will seem, to be dried, follows the string, wrinkling, and skin aging process accelerates.Therefore moisture is to skin health to Guan Chong
It wants, water conservation moisturizing is always one of most important research topic of skin protection cosmetics.Moisturizing class cosmetics mainly pass through moisturizer
Play effect, moisturizer is to prolong to simulate the natural moisture preserving system being made of in human skin oil, water, NMF, effect
Slow loss of moist increases dermal-epidermal moisture penetration, protection is temporarily provided for skin, reduces damage, promotes repair process.It passes
Blanket insurance humectant mainly has glycerol, propylene glycol, butanediol, sorbierite, pyrrolidone sodium carboxylate, polyethylene glycol, sodium lactate etc., they
By being chemically synthesized, in addition to pyrrolidone sodium carboxylate, other are still now widely used cosmetic humectant.They
All have the advantages that performance of keeping humidity is good, and cheap and easy to get.Polysaccharide moisturizer, due to it has no toxic side effect, with skin
The characteristics such as affinity is good become a new hot spot of research and development of cosmetic humectant.The moisture-keeping function of polysaccharide is: 1. more
Hydroxyl, carboxyl and other polar groups in glycan molecule can form hydrogen bond with hydrone and combine a large amount of moisture, meanwhile, polysaccharide
Strand is also interweaved and reticulates, and in addition with the Hydrogenbond of water, plays very strong water retention.2. polysaccharide has good
Filming performance can form one layer of uniform film in skin surface, reduce the moisture evaporation of skin surface.Therefore, the height of polysaccharide
Water imbibition and good film forming perfect combination, can provide good moistening effect for skin.Therefore, polysaccharide is answered as moisturizer
For cosmetics, demand of the people to high-quality cosmetics is met, the development trend of moisturizing cosmetic is become.
More than 10 effective component containing flavones and its glycoside, organic acid, coumarinoids etc. in viola mandshurica alcohol extract, flavones
And its glycoside is main component.Flavone compound apiolin and its glycosides, luteolin and its glycosides etc..Apiolin and its glycosides have
The a variety of pairs of skin beneficiating effects such as anti-irritant, anti-inflammatory, antiallergy, anti-aging；Luteolin and its glycosides can inhibit staphylococcus and
The growth of hay bacillus；There is anti-inflammatory effect, treats dermatitis with phosphatide compatibility；Inhibit hyaluronidase activity, it is same with hyaluronic acid
With the physiological activity that can extend the substance；It is strong to the capture ability of oxygen radical.In conclusion viola mandshurica alcohol takes object to have
It is antibacterial, anti-inflammatory and anti-oxidant and other effects, and containing there are many flavone compounds to skin beneficiating.Also contain in its water extract
More viscous polysaccharide can be used as moisturizer and be applied in skin care item, and have good performance of keeping humidity, to answer in cosmetics
With providing foundation.
Dong Wei, Yu Tianhao, week respect in " application of the Herba Violae extract in the cosmetics " paper delivered, and propose purple
Flower Chinese violet extract can effectively improve skin moisture content in short term and reduce water loss, and long-time service can be effectively controlled oil
Rouge secretion and raising skin elasticity.It is demonstrated experimentally that the water extract of viola mandshurica contains a large amount of mucilaginous substance, illustrate in viola mandshurica
Ingredient containing more mucopolysaccharide, and itself with antibacterial, oxidation resistant effect can be used as good moisturizer application
In cosmetics.
The Chinese patent literature of 108553320 A of publication No. CN (application number 201810619590.4) discloses one kind and sleeps
Dormancy facial mask；The Chinese patent literature of 107375080 A of publication No. CN (application number 201710659046.8) discloses a kind of white tea
Moisturizing sleep mask and preparation method thereof；The Chinese patent of 106691964 A of publication No. CN (application number 201611186346.0)
Document discloses a kind of sleep mask with moisturizing moisturizing；106727113 A (application number of publication No. CN
201611141334.6) Chinese patent literature disclose a kind of sleep mask of long-acting moisturizing；Publication No. CN 105456137
The Chinese patent literature of A (application number 201511015644.9) discloses a kind of sleep mask of deep moisturizing；Publication No. CN
The Chinese patent literature of 105662952 A (application number 201610044102.2) disclose a kind of natural plants composite humectant and
Preparation method.The method of these preparation sleep masks is added the risk of sensitization mostly with chemical component, and addition mostly
The effective component of plant is without its provable good moisturizing of experimental data and its auxiliaring effect.In the preparation method of polysaccharide moisturizer
And compounded with a variety of plant extraction liquids, the extraction of existing polysaccharide moisturizer and purifying process complexity and
The problems such as expensive.
Summary of the invention
To solve the above-mentioned problems, the purpose of the present invention is to provide a kind of moisturizing moisturizings of moisturizer containing viola mandshurica to sleep
Dormancy facial mask and preparation method thereof takes moisturizer made of the extract of viola mandshurica to be applied in sleep mask, and manufactured one
The moisturizing moisturizing sleep mask of kind moisturizer containing viola mandshurica.Viola mandshurica itself is used as a kind of excellent natural product extraction
Object, ethanol extract have that its is antibacterial, anti-inflammatory and anti-oxidant and other effects, and because containing more viscous polysaccharide in its water extract,
And there is good performance of keeping humidity.Therefore the two large effect extracts that the present invention obtains viola mandshurica difference extracting mode are incorporated in
Together, Herba Violae extract is made, then cooperates glycerol and hydrogenated starch hydrolysate, so that the present invention has the more of synergy
Imitate strong moisture-keeping function.Viola mandshurica involved in the present invention, yield is high, and resource is wide, and price is low, and the extraction process of extract is opposite
Simply, production cost is low, and there are also its natural environmental-protectives compared with moisturizer and its sleep mask made of the conventional chemical methods, to skin
The advantage of safe fanout free region.
Beneficial effects of the present invention:
1. moisturizing moisturizing sleep mask of the invention, is made using viola mandshurica moisturizer by primary raw material, there is multiple-effect to protect
The effect of wet moisturizing, cooperates flavonoids skin care ingredient on the basis of plant polyose strength moisturizing, not only can effectively improve because of skin
The dry bring sebum secretion of skin is few, has dry skin, lacks the skin problem of gloss, moreover it is possible to play anti-oxidant, antibacterial and other effects.
2. the sleep mask in the present invention can be applied to face after face cleaning every night, does not have to cleaning, can directly fall asleep, make
With convenient, and to no skin irritation, the phenomenon that long-time service is not in dermal toxicity.
3. the Herba Violae extract added in the present invention, using ethanol immersion and water extraction to viola mandshurica medicinal material into
Row extracts, and extract combines the two large effect ingredients contained in ethanol extract and water extract, both substantially increased pale reddish brownly
The utilization rate of fourth raw material, and the sleep mask in the present invention is made to achieve the purpose that multiple-effect moisturizing.
4. more common moisturizer most of at present is still based on chemically synthesized alcohols material, and chemically synthesized guarantor
Humectant often has the generation of sensitization symptom.The viola mandshurica moisturizer for including in the present invention, no other chemical components addition, safety
To skin fanout free region, have the characteristics that mild, nonirritant.
5. manufacture craft difficulty of the invention is small, the extraction step of viola mandshurica is simple, and economic cost is few, is suitable for industry
Large-scale production, has extensive market popularization value, and social and economic benefit is significant.
6, Herba Violae extract of the present invention is mutually formulated by alcohol extract with polysaccharide solution, in leaching liquor
It is combined with the distinctive performance of keeping humidity of polysaccharide solution containing there are many flavone compounds to skin beneficiating, therefore imparts this hair
The performance of bright multiple-effect moisturizing.
7, viola mandshurica itself is used as a kind of excellent natural extracts, ethanol extract have its it is antibacterial, anti-inflammatory with
And it is anti-oxidant and other effects, and because containing more viscous polysaccharide in its water extract, and have good performance of keeping humidity.Therefore the present invention
The two large effect extracts that viola mandshurica difference extracting mode is obtained are combined together, and Herba Violae extract are made, then match
Glycerol and hydrogenated starch hydrolysate are closed, so that the present invention has the synergistic strong moisture-keeping function of multiple-effect.Involved in the present invention
Viola mandshurica, yield is high, and resource is wide, and price is low, and the extraction process of extract is relatively easy, and production cost is low, with traditional chemical
Moisturizer and its sleep mask made of method compare also its natural environmental-protective, to the advantage of skin safe fanout free region.
Detailed description of the invention
Fig. 1 is Scavenging activity effect picture of the Herba Violae extract to hydroxyl radical free radical of the preparation of embodiment 1.
Specific embodiment
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction can't be constituted to the present invention.
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..Unless otherwise specified, embodiment
Used in the conventional means that are well known to those skilled in the art of technological means, raw materials used is commercial goods.
Embodiment 1
A kind of preparation method of the moisturizing moisturizing sleep mask of Herba Violae extract, comprising the following steps:
B1, by weight parts by weight raw material preparation viola mandshurica moisturizer, thickening polymer, trehalose, small molecule are transparent
Matter acid sodium, 1,3 butanediols, preservative and deionized water；
B2,20 parts by weight viola mandshurica moisturizer are added 10 parts by weight of deionized water dilute, is stirring evenly and then adding into 2 weight
Part trehalose and 3 parts by weight, 1,3 butanediol, stir evenly, obtain solution A；
B3,3 parts by weight carbomers and 0.5 parts by weight micromolecule hyaluronic acid sodium are uniformly mixed, are added in step B2
Solution A then sequentially adds the deionized water of 0.05 parts by weight Phenoxyethanol and 42 parts by weight；Low whipping speed is 50r/min
Under conditions of, stirring is separated to thickening polymer with micromolecule hyaluronic acid sodium with chamber wall, is allowed to be suspended in solution, sufficiently
Swelling forms gelling agent to get the moisturizing moisturizing sleep mask containing Herba Violae extract.
A kind of viola mandshurica moisturizer preparation method, is made by following steps:
It is molten with 20 parts by weight of deionized water by 15 parts by weight of glycerin and 8 parts by weight of hydrogenated glucidtemns under S1, room temperature
Solution, stirring are uniformly mixed it；
S2,25 parts by weight Herba Violae extract solution are added while stirring, are uniformly mixed；
S3,28 parts by weight of deionized water are added, are uniformly mixed to get viola mandshurica moisturizer.
Herba Violae extract is made by following steps: (1) Tokyo Violet Herb of 50 parts by weight is weighed, through mass fraction
It is extracted 3 times for 95% ethanol solution, merges leaching liquor, deionized water is added after being dried, be formulated as the purple that concentration is 1mL/g
Flower Chinese violet leaching liquor, the viola mandshurica dregs of a decoction set drying at room temperature.(2) the viola mandshurica dregs of a decoction of 60 parts by weight steps (1) acquisition are weighed,
Deionized water is added with the ratio of solid-liquid ratio 1:10, decocts 2h, the dehydrated alcohol of 4 times of volumes of the viola mandshurica dregs of a decoction is added in filtering,
It stirs evenly, stands overnight, filter, gained is precipitated as polysaccharide crude；(3) step (2) resulting polysaccharide crude successively use dehydrated alcohol,
Acetone, ether wash 2 times respectively, set after drying in drying box, distilled water is added to dissolve, and it is that 1mL/g viola mandshurica is more that concentration, which is made,
Sugar juice；(4) by the viola mandshurica leaching liquor of step (1) preparation and the viola yedoensis solution of step (3) preparation by 1:4's
Volume ratio mixes to get Herba Violae extract.
Embodiment 2
A kind of preparation method of the moisturizing moisturizing sleep mask of Herba Violae extract, comprising the following steps:
B1, by weight parts by weight raw material preparation viola mandshurica moisturizer, thickening polymer, trehalose, small molecule are transparent
Matter acid sodium, 1,3 butanediols, preservative and deionized water；
B2,35 parts by weight viola mandshurica moisturizer are added 13 parts by weight of deionized water dilute, is stirring evenly and then adding into 3 weight
Part trehalose and 4 parts by weight, 1,3 butanediol, stir evenly, obtain solution A；
B3,4 parts by weight carbomers and 0.8 parts by weight micromolecule hyaluronic acid sodium are uniformly mixed, are added in step B2
Solution A then sequentially adds the deionized water of 1 parts by weight Phenoxyethanol and 50 parts by weight；Low whipping speed is the item of 50r/min
Under part, stirring is separated to thickening polymer with micromolecule hyaluronic acid sodium with chamber wall, is allowed to be suspended in solution, sufficiently molten
It is swollen, gelling agent is formed to get the moisturizing moisturizing sleep mask containing Herba Violae extract.
A kind of viola mandshurica moisturizer preparation method, is made by following steps:
It is molten with 20 parts by weight of deionized water by 15 parts by weight of glycerin and 8 parts by weight of hydrogenated glucidtemns under S1, room temperature
Solution, stirring are uniformly mixed it；
S2,25 parts by weight Herba Violae extract solution are added while stirring, are uniformly mixed；
S3,28 parts by weight of deionized water are added, are uniformly mixed to get viola mandshurica moisturizer.
The Herba Violae extract is made by following steps: (1) Tokyo Violet Herb of 65 parts by weight is weighed, through matter
It measures the ethanol solution that score is 95% to extract 3 times, merges leaching liquor, deionized water is added after being dried, being formulated as concentration is
The viola mandshurica leaching liquor of 1mL/g, the viola mandshurica dregs of a decoction set drying at room temperature.(2) the pale reddish brown of 70 parts by weight steps (1) acquisition is weighed
Deionized water is added with the ratio of solid-liquid ratio 1:10 in the Chinese violet dregs of a decoction, decocts 2h, and 4 times of volumes of the viola mandshurica dregs of a decoction are added in filtering
Dehydrated alcohol, stir evenly, stand overnight, filter, gained is precipitated as polysaccharide crude；(3) step (2) resulting polysaccharide crude is successively
It is washed respectively 3 times with dehydrated alcohol, acetone, ether, sets after being dried in drying box, distilled water is added to dissolve, it is 1mL/g that concentration, which is made,
Viola yedoensis solution；(4) by the viola yedoensis of the viola mandshurica leaching liquor of step (1) preparation and step (3) preparation
Solution is mixed by the volume ratio of 1:4 to get Herba Violae extract.
Embodiment 3
A kind of preparation method of the moisturizing moisturizing sleep mask of Herba Violae extract, comprising the following steps:
B1, by weight parts by weight raw material preparation viola mandshurica moisturizer, thickening polymer, trehalose, small molecule are transparent
Matter acid sodium, 1,3 butanediols, preservative and deionized water；
B2,50 parts by weight viola mandshurica moisturizer are added 15 parts by weight of deionized water dilute, is stirring evenly and then adding into 5 weight
Part trehalose and 6 parts by weight, 1,3 butanediol, stir evenly, obtain solution A；
B3,5 parts by weight carbomers and 1 parts by weight micromolecule hyaluronic acid sodium are uniformly mixed, are added molten in step B2
Liquid A then sequentially adds the deionized water of 2 parts by weight methyl hydroxybenzoates and ethyl hydroxy benzoate and 60 parts by weight；Low whipping speed is
Under conditions of 50r/min, stirring is separated to thickening polymer with micromolecule hyaluronic acid sodium with chamber wall, is allowed to be suspended in solution
In, it is sufficiently swollen, forms gelling agent to get the moisturizing moisturizing sleep mask containing Herba Violae extract.
A kind of viola mandshurica moisturizer preparation method, is made by following steps:
It is molten with 20 parts by weight of deionized water by 15 parts by weight of glycerin and 8 parts by weight of hydrogenated glucidtemns under S1, room temperature
Solution, stirring are uniformly mixed it；
S2,25 parts by weight Herba Violae extract solution are added while stirring, are uniformly mixed；
S3,28 parts by weight of deionized water are added, are uniformly mixed to get viola mandshurica moisturizer.
The Herba Violae extract is made by following steps: (1) Tokyo Violet Herb of 80 parts by weight is weighed, through matter
It measures the ethanol solution that score is 95% to extract 3 times, merges leaching liquor, deionized water is added after being dried, being formulated as concentration is
The viola mandshurica leaching liquor of 1mL/g, the viola mandshurica dregs of a decoction set drying at room temperature.(2) the pale reddish brown of 75 parts by weight steps (1) acquisition is weighed
Deionized water is added with the ratio of solid-liquid ratio 1:10 in the Chinese violet dregs of a decoction, decocts 2h, and 4 times of volumes of the viola mandshurica dregs of a decoction are added in filtering
Dehydrated alcohol, stir evenly, stand overnight, filter, gained is precipitated as polysaccharide crude；(3) step (2) resulting polysaccharide crude is successively
It is washed respectively 3 times with dehydrated alcohol, acetone, ether, sets after being dried in drying box, distilled water is added to dissolve, it is 1mL/g that concentration, which is made,
Viola yedoensis solution；(4) by the viola yedoensis of the viola mandshurica leaching liquor of step (1) preparation and step (3) preparation
Solution is mixed by the volume ratio of 1:4 to get Herba Violae extract.
Performance test
1. heat-resisting, experiment test of resisting cold
1.1 test methods: moisturizing MASQUE APAISANT HYDRATANT prepared by Example 1, by heat-resisting its stability of cold-resistant measuring,
It sequentially includes the following steps:
(1) manufactured sleep mask sample is respectively charged into the test tube inner height about 80mm of 2 20mm × 120mm, beyond the Great Wall
Clean rubber plug.
(2) test tube to be checked is placed in and is pre-adjusted to the constant incubator of (40 ± 1) DEG C, taken out afterwards for 24 hours, it is extensive
After answering to room temperature compared with the sample of another test tube carries out range estimation.
(3) sample is respectively charged into the test tube of 2 20mm × 120mm, height about 80mm, beyond the Great Wall clean rubber plug.
(4) test tube to be checked is placed in and is pre-adjusted to the refrigerator of (- 8 ± 2) DEG C, taken out afterwards for 24 hours, restored to room
The sample of another test tube of Wen Houyu carries out range estimation comparison.
1.2 experiment conclusion
Show after cold-resistant heat-resistant experiment by range estimation, its appearance of sleep mask sample of the invention will not change
Become.
2. the measuring of hydroscopicity:
2.1 test methods: viola mandshurica moisturizer prepared by Example 1 passes through gravimetric detemination viola mandshurica moisturizing
The hydroscopicity of agent, sequentially includes the following steps:
(1) prepare before test: in experiment proxima luce (prox. luc), placing the saturation potassium nitrate solution of 50mL at drier bottom, make liquid
Depth is greater than 1cm, places porous barrier thereon, closes the lid, and keeps sealing state, is placed in 25 degrees Celsius of environment.To molten
After liquid upper air saturation, that is, it can reach and maintain 94% relative humidity.
(2) 0.3% micromolecule hyaluronic acid sodium water solution is prepared as control sample.
(3) it product testing: selects the glass plate of 5*5cm to clean drying, and sticks 3M medical adhesive tape.Weigh 0.1g's respectively
0.3% micromolecule hyaluronic acid sodium water solution of viola mandshurica moisturizer and 0.1g, is uniformly applied to 3M glue for it respectively
It takes, dosage is about 2mg/cm2, weighing quality is W1.Then by the glass plate after smearing be placed in simple humidistat it is porous every
On plate, and guarantee the circulation of partition or more air, (2h, 4h, 6h, 8h) takes out rapidly, is weighed as W2 after placing a period of time, puts down
Row is tested three times, is averaged.
(4) final result is presented with hydroscopicity, measures the formula of hydroscopicity: Rr (%)=(quality W2- sample after sample moisture absorption
Quality W1 before product moisture absorption) quality W1 before/sample moisture absorption.
2.2 experimental datas are shown in Table 1
The hydroscopicity of 1 viola mandshurica moisturizer of table compares
Sodium Hyaluronate is a kind of glutinous sugar of bionical object, its theoretical water retention value, which reaches 1000mL/g, to be retained in human skin
Key component, be the good moisturizer of a kind of moistening effect.It can be obtained from above data, a kind of moisture absorption of viola mandshurica moisturizer
Rate is more somewhat higher than micromolecule hyaluronic acid sodium hydroscopicity, can illustrate that the moistening effect of viola mandshurica is good.
3. the measuring of percentage of water loss
3.1 test methods:
Viola mandshurica moisturizer prepared by embodiment 1, by the percentage of water loss of gravimetric detemination viola mandshurica moisturizer, by with
Lower step carries out:
(1) prepare before test: gravimetric detemination moisturizer percentage of water loss must carry out in a constant temperature, constant humidity environment.With test
Proxima luce (prox. luc), drier bottom place 50mL unsaturated carbonate potassium solution, make liquid depth be greater than 1cm, place thereon it is porous every
Plate.It closes the lid, keeps closed state, be placed in 25 degrees Celsius of environment, after water vapor in air partial pressure is constant, can maintain
About 43% relative humidity.
(2) 0.3% micromolecule hyaluronic acid sodium water solution is prepared as sample to be tested.
(3) it product testing: selects the glass plate of 5*5cm to clean drying, and sticks the medical adhesive tape of 3M.0.1g is weighed respectively
Viola mandshurica moisturizer and 0.1g 0.3% micromolecule hyaluronic acid sodium water solution, it is uniformly applied to 3M respectively
On adhesive tape, dosage is about 2mg/cm2, weighing quality is M1.Then the glass plate after smearing is placed in the porous of simple humidistat
On partition, and guarantee the circulation of partition or more air, (2h, 4h, 6h, 8h) takes out rapidly, is weighed as M2 after placing a period of time,
It tests, is averaged three times in parallel.
(4) final result is presented with percentage of water loss, the formula of gravimetric detemination percentage of water loss: (%)=(quality after sample moisture absorption
Quality M2 before M1- sample moisture absorption) quality M1 before/sample moisture absorption
3.2 experimental datas are shown in Table 2
The comparison of 2 viola mandshurica moisturizer percentage of water loss of table
From above-mentioned experimental result, the dehydration ability of the viola mandshurica moisturizer in the present invention with small point of 0.3%
Sub- aqueous solution of sodium hyaluronate is substantially similar, and dehydration ability is all weaker.
4. the measuring of moisture content of skin:
Moisturizing moisturizing sleep mask prepared by embodiment 1 is as given the test agent, using commercially available sleep mask as control sample, into
The measuring of row moisture content of skin, sequentially includes the following steps:
(1) subject's requirement and experimental condition: 6 age healths between 21~38 years old are selected on a voluntary basis
Subject, it is desirable that without skin medical history and cosmetic allergic contact dermatitis history.Subject's warm water cleaning inner forearm (short-term) before detecting, test
Before need to stable at least 30min under test conditions, must not drink water, feed during test, strenuous exercise, must not be used during test
Other same type products.Test environment: 20-22 DEG C of temperature, relative humidity 40-60%.
(2) given the test agent uses: in left and right, two-arm uses given the test agent and control sample to every subject respectively, test
Point label: in the left and right inner forearm mold labeled test region (4cm × 6cm) of every subject.Sample by (2.0 ±
0.1)mg/cm2Dosage, be uniformly applied to trial zone.
(3) skin moisture content measures: measuring subject's inner forearm mark with moisture tester Corneometer CM825
Moisture content when note point is before and using rear 30min, 60min, 90min, 120min.To evaluate containing Herba Violae extract
Moisturizing moisturizing sleep mask is averaged for each test point parallel testing 5 times in a short time to the influence of moisture of skin.As a result it uses
Moisture content expression, unit a.u..
(4) test result is presented with hydration rate
(5) data such as the following table 3:
The moistening effect of 3 viola mandshurica sleep mask of table
Skin hydration rate is bigger, and moisture content is bigger, and moistening effect is more obvious.It can be obtained by above table, contain viola mandshurica
The more commercially available sleep mask of moisturizing moisturizing sleep mask of extract has preferable water holding capacity, and has the effect of lasting water lock
Fruit.
4. bacteriostatic experiment measures
4.1 test method
Herba Violae extract prepared by embodiment 1 is measured the bacteriostasis rate of Herba Violae extract by bacteriostatic experiment, pressed
Following steps carry out:
(1) by the test tube that agar is housed, Escherichia coli, staphylococcus aureus, bacillus subtilis the inoculation of bacterium: are housed
The culture medium of bacterium is put in superclean bench, ultraviolet-sterilization 15min.A small amount of bacterium is scraped, is coated in the test tube equipped with agar
On agar slant, test tube is wrapped, is placed on 37 DEG C of constant incubator culture two days.
(2) rubbing method surveys the fungistatic effect of extracting solution: the inclined-plane bacterium of culture is dissolved in super-clean bench with 3mL sterile water,
Bacterium solution is poured on spare in clean conical flask, is drawn in 150 microlitres of bacterium solutions and batch cultur base with liquid-transfering gun, use spreader
Bacterium solution is smoothened.Culture medium is sealed with sealed membrane, culture medium is not buckled to, and is put into 37 DEG C of constant incubator and is cultivated one day.
In superclean bench, sterilized Oxford cup is put down gently on culture medium, draws viola mandshurica extracting solution with asepsis injector,
10 drop of injection, culture medium open-ended are not buckled to, are put into 37 DEG C of constant incubators and cultivate two days in toward Oxford cup, measure antibacterial
Circle.
4.2 experimental data
The fungistatic effect measurement result of Herba Violae extract such as table 4:
Inhibitory effect of 4 Herba Violae extract of table to three kinds of bacteriums
| Strain name | Escherichia coli | Staphylococcus aureus | Bacillus subtilis |
| Antibacterial circle diameter | 16mm | 15mm | 12mm |
Test criterion according to antibacterial circle: it is extremely sensitive that antibacterial loop diameter, which is greater than 20mm,；15~20mm is high sensitive；10
~15mm is middle sensitivity；7~9mm is muting sensitive sense；It is insensitive less than 7mm.As seen from table, the extract of viola mandshurica to
Upper three kinds of common bacteriums have certain antibiotic property.
5. anti-oxidant measuring
5.1 test method
Herba Violae extract prepared by embodiment 1 measures the inoxidizability of Herba Violae extract by bacteriostatic experiment,
It sequentially includes the following steps:
(1) preparation of viola mandshurica solution
The extract for taking 0.2g viola mandshurica is made into 10mL solution with the phosphate buffer of pH=6.8.0.5mL is taken again
Being diluted to 25mL is Herba Violae extract, that is, dilutes 500 times.
(2) measurement of hydroxyl radical free radical (- OH)
A 50mL volumetric flask number blank is taken, adds the FeSO of 5mL 9mmol/L inward4, 5mL9mmol/L bigcatkin willow
Acid-ethanol solution, 5mL0.3% hydrogen peroxide, then be settled to 50mL with deionized water, shake up and stand 30min.With ultraviolet point
Light photometer measures its absorbance value in wavelength 510nm and its average value is taken to be denoted as A0And record data.
(3) the effect measurement of Herba Violae extract antioxidation in vitro
Take and take 10 volumetric flasks respectively, label 1,2,3,4,5,6,7,8,9,10, then respectively add 0.25mL, 0.50mL,
It is past after the Herba Violae extract of 0.75mL, 1.00mL, 1.25mL, 1.50mL, 1.75mL, 2.00mL, 2.25mL, 2.50mL
In add 2.5mLFeSO4, add 5mL salicylic acid-ethanol solution and 2.5mLH2O2, it is settled to 25mL with deionized water, is shaken up simultaneously
Stand 30min.Its absorbance value A is measured in wavelength 510nm with ultraviolet specrophotometerSIt is molten to compare effective pH6.8 phosphoric acid buffer
Liquid replaces viola mandshurica extracting solution AS0。
Free radical scavenging activity calculation formula are as follows:
In formula, A0For the absorbance of blank tube, AxFor the absorbance after free radical scavenger is added.
Illustrate that Herba Violae extract has preferable antioxidation by Fig. 1, and when concentration is 0.04mg/mL, antioxygen
It is most obvious to change effect, hydroxyl radical free radical clearance rate is up to 84.43%.
6. product effect assessment
Moisturizing moisturizing sleep mask containing Herba Violae extract prepared by embodiment 1, carries out product effect assessment to it,
It sequentially includes the following steps:
(1) it invites 90 between 20~50 years old, the female volunteers of skin health, is randomly divided into 9 groups, every group of 20 people put down
It at equal 28 ± 2 years old age, tries out respectively and observes and experience using effect.
(2) application method: volunteer cleans face, and after carrying out basic skin care, above-mentioned sleep mask is uniformly applied to face
Portion washes away after getting up early, and regulation uses 2 times weekly, adheres to using one month, at least check weekly once to understand whether there is or not whole body and
Local adverse reaction, and result is recorded in detail.Test assessment result such as the following table 4:
4 staining effect table of table
Experiment conclusion: the present invention liked and approved by vast volunteer on probation, and volunteer on probation indicates that sleep mask makes
With convenient, the effect of moisturizing moisturizing is good, feel after trying out one month dry skin, coarse, low and deep etc. be improved significantly, skin
Water profit is smooth, flexible.All there is allergic phenomena in non-someone in volunteer on probation simultaneously, does not also occur pruitus, thorn
Bitterly, the situations such as redness.Therefore, the moisturizing moisturizing sleep mask in the present invention is mildly safe, can be used for a long time, there is potent moisturizing
Effect.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (10)
1. a kind of viola mandshurica moisturizer, which is characterized in that be made of following raw material: 25 parts of Herba Violae extract,
15 parts of glycerol, 8 parts of hydrogenated starch hydrolysate and 48 parts of deionized water.
2. a kind of viola mandshurica moisturizer according to claim 1, which is characterized in that the Herba Violae extract by
Following steps are made: (1) weighing the Tokyo Violet Herb of 50-80 parts by weight, the ethanol solution extraction 3 for being 95% through mass fraction
It is secondary, merge leaching liquor, deionized water is added after being dried, is formulated as the viola mandshurica leaching liquor that concentration is 1mL/g, viola mandshurica
The dregs of a decoction set drying at room temperature；(2) the viola mandshurica dregs of a decoction of 60-75 parts by weight step (1) acquisition are weighed, with the ratio of solid-liquid ratio 1:10
Deionized water is added, decocts 2 h, filtering is added the dehydrated alcohol of 4 times of volumes of the viola mandshurica dregs of a decoction before boiling, stirs evenly, stood
It at night, filters, gained is precipitated as polysaccharide crude；(3) step (2) resulting polysaccharide crude successively uses dehydrated alcohol, acetone, ether point
Xi Di not be 2-3 times, it sets after being dried in drying box, distilled water is added to dissolve, it is 1mL/g viola yedoensis solution that concentration, which is made,；(4)
The viola mandshurica leaching liquor of step (1) preparation and the viola yedoensis solution of step (3) preparation is mixed by the volume ratio of 1:4
It closes to get Herba Violae extract.
3. a kind of viola mandshurica moisturizer preparation method, which is characterized in that be made by following steps:
Under S1, room temperature, by 15 parts by weight of glycerin and 8 parts by weight of hydrogenated glucidtemns, is dissolved, stirred with 20 parts by weight of deionized water
Mixing is uniformly mixed it；
S2,25 parts by weight Herba Violae extract solution are added while stirring, are uniformly mixed；
S3,28 parts by weight of deionized water are added, are uniformly mixed to get viola mandshurica moisturizer.
4. a kind of viola mandshurica moisturizer preparation method according to claim 3, it is characterised in that: the step S2's stirs
Mixing speed is 100r/min, mixing time 3min.
5. a kind of moisturizing moisturizing sleep mask of viola mandshurica moisturizer described in 1-2 containing claim, which is characterized in that by following
Raw material is made: 20-50 parts of viola mandshurica moisturizer, 3-5 parts of thickening polymer, 2-5 parts of trehalose, small molecule hyalomitome
Sour sodium 0.5-1 parts, 3-6 parts of 1,3 butanediol, 0.05-2 parts of preservative and 52-75 parts of deionized water.
6. a kind of moisturizing moisturizing sleep mask of moisturizer containing viola mandshurica according to claim 5, it is characterised in that: institute
It states in the high molecular polymer that thickening polymer synthesizes for carboxylic acid polyalcohol, cross-linked polyacrylate polymer, cellulose ethers
One or more.
7. a kind of moisturizing moisturizing sleep mask of moisturizer containing viola mandshurica according to claim 5, it is characterised in that: institute
Stating thickening polymer is carbomer.
8. a kind of moisturizing moisturizing sleep mask of moisturizer containing viola mandshurica according to claim 5, which is characterized in that institute
The preservative stated is at least one of Phenoxyethanol, methyl hydroxybenzoate and ethyl hydroxy benzoate.
9. the moisturizing moisturizing sleep mask of a kind of moisturizer containing viola mandshurica according to claim 5, by following parts by weight
Raw material is made: 25 parts of viola mandshurica moisturizer, 3 parts of carbomer, 3 parts of trehalose, 0.8 part of micromolecule hyaluronic acid sodium, 1,3 fourths two
3 parts of alcohol, 0.5 part of Phenoxyethanol and 65 parts of deionized water.
10. a kind of preparation method of the moisturizing moisturizing sleep mask of Herba Violae extract as claimed in claim 5, feature exist
In, comprising the following steps:
B1, by weight parts by weight raw material preparation viola mandshurica moisturizer, thickening polymer, trehalose, micromolecule hyaluronic acid
Sodium, 1,3 butanediols, preservative and deionized water；
B2,20-50 parts by weight viola mandshurica moisturizer is added 10-15 parts by weight of deionized water dilute, is stirring evenly and then adding into 2-5
1,3 butanediol of parts by weight trehalose and 3-6 parts by weight, stirs evenly, obtains solution A；
B3,3-5 parts by weight thickening polymer and 0.5-1 parts by weight micromolecule hyaluronic acid sodium are uniformly mixed, step B2 is added
In solution A, then sequentially add the deionized water of 0.05-2 parts by weight preservative and 42-60 parts by weight；Low whipping speed is
Under conditions of 50r/min, stirring is separated to thickening polymer with micromolecule hyaluronic acid sodium with chamber wall, is allowed to be suspended in solution
In, it is sufficiently swollen, forms gelling agent to get the moisturizing moisturizing sleep mask containing Herba Violae extract.
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