CN111991309A - Composition with repairing and moisturizing effects and preparation method and application thereof - Google Patents
Composition with repairing and moisturizing effects and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a composition with repairing and moisturizing functions, a preparation method and application thereof, wherein the preparation raw materials of the composition with repairing and moisturizing functions comprise: arginine/lysine polypeptide, Althaea officinalis extract, Eisenia mexicana extract, Cannabis sativa extract, ectoin, Artocarpus heterophyllus extract, Achillea millefolium extract, and carboxymethyl chitosan. The composition disclosed by the invention can help the skin to repair the barrier autonomously, improve the physiological metabolism mechanism in the skin in a multiple-effect manner, efficiently moisturize and moisturize, relieve the discomfort of the skin and realize long-acting strengthening of the skin barrier.
Description
Technical Field
The invention belongs to the technical field of medical cosmetics, and particularly relates to a composition with repairing and moisturizing effects, and a preparation method and application thereof.
Background
The skin is the largest organ of the human body, the outermost layer is the epidermis consisting of 5 layers of keratinocytes, from the outside to the inside, the stratum corneum, the stratum lucidum, the stratum granulosum, the stratum spinosum and the stratum basale are respectively. The stratum corneum is the outermost layer of the epidermis, and the normal stratum corneum has a water content of 20% to 35%, and if less than 10%, the skin barrier function is impaired.
Factors such as UV, radiation, smoke, age, nutrition, health, etc., cause skin to be lack of water, cause skin barrier function to be impaired, and cause various skin diseases such as skin itch, skin pain, red blood streak, atopic dermatitis, and dry skin, so that moisture retention is essential for repairing skin barrier.
However, in the current market, cosmetics for repairing skin barrier are fully moisturizing or are locked by using exogenous moisturizers, for example, a composition for repairing skin barrier disclosed in patent CN201610216262.0 "a composition for repairing skin barrier" is prepared from the following raw materials in percentage by weight: 0.1-1% of sodium hyaluronate, 0.5-3% of trehalose, 5-25% of humectant and 71-94.4% of water, although the moisturizing effect can be quickly achieved by an exogenous humectant, the discomfort of the skin can be temporarily relieved only to a certain extent, and the skin barrier can not be fundamentally repaired, so that the skin state can be improved for a long time.
Disclosure of Invention
The invention aims to provide a composition with repairing and moisturizing effects (hereinafter referred to as repairing and moisturizing composition or composition) and a preparation method and application thereof.
The technical scheme adopted by the scheme is as follows:
the first part of the invention is to provide a repairing and moisturizing composition, which is prepared from the following raw materials: arginine/lysine polypeptide, Althaea officinalis extract, Eisenia mexicana extract, Cannabis sativa extract, ectoin, Artocarpus heterophyllus extract, Achillea millefolium extract, and carboxymethyl chitosan.
The amino acid/lysine polypeptide, namely the conotoxin and the conopeptide can regulate and control the contraction of neuromuscular by acting on a ligand gated ion channel, has the effect of relieving and can tighten skin.
The marshmallow extract is rich in unsaturated fatty acids necessary for human body, and has effects of scavenging superoxide radical, promoting skin metabolism, repairing and resisting aging; and has excellent moisture-retaining ability.
The Eisenia splendens extract contains red algae sulfoacid polysaccharide and has good oxidation resistance; can help repair the barrier of the damaged skin, improve the percutaneous loss of the skin moisture and improve the water locking capacity of the skin.
The industrial hemp extract is rich in Cannabidiol (CBD), unsaturated fatty acid and the like, and has stronger antioxidant activity; has antibacterial and anti-inflammatory effects, and has soothing effect; meanwhile, the secretion of skin grease can be adjusted by adjusting an intracellular signal path, and the skin barrier can be repaired.
Ectoin, also known as tetrahydro-methyl-pyrimidine-carboxylic acid (Ectoin). The ring structure of the ectoine molecule has stronger electronegativity, is easy to form hydrogen bonds with water molecules, enhances the association capability of the water molecules, can structure free water in cells, reduces the water evaporation in the skin, and continuously improves the moisture retention capability of the skin; the ectoin can effectively improve the immune protective capability of skin cells, increase the cell repair capability, ensure that the skin can effectively resist the invasion of microorganisms and allergens, play a good repair effect on the states of skin desquamation, redness, fever and the like, and accelerate the repair of skin barriers.
The millettia extract can effectively lock water and preserve moisture for a long time, and enables the skin to be tight, tender and smooth and glossy.
Yarrow extract, having strong antibacterial and anti-inflammatory properties, and soothing the skin; inhibiting elastase, promoting proliferation of epidermal keratinocyte, restoring elasticity of skin fibrous tissue, accelerating metabolism of skin cells, and repairing damaged skin.
Carboxymethyl chitosan, also known as MHA Plus, can significantly improve the water loss of the skin epidermis through its extremely strong film-forming property; meanwhile, the antibacterial agent can adsorb bacteria with negative charges, interfere normal metabolism of cells and inhibit bacterial reproduction.
Compared with the prior art, the invention compounds arginine/lysine polypeptide, marshmallow extract, maidenhair extract, industrial hemp extract, ectoin, millettia extract, milfoil extract and carboxymethyl chitosan, helps the skin to repair the barrier from inside to outside through multi-component cooperation, improves the internal physiological metabolism mechanism of the skin in multiple effects, moisturizes and moisturizes water efficiently, relieves the discomfort of the skin, and realizes long-acting strengthening of the skin barrier.
Preferably, the repairing and moisturizing composition is prepared from the following raw materials in parts by weight:
0.01-0.1 parts of arginine/lysine polypeptide;
1-4 parts of an extract of marshmallow;
1-4 parts of an Eisenia variegata extract;
0.5-2 parts of industrial hemp extract;
0.5-2 parts of ectoin;
1-5 parts of Artocarpus heterophyllus extract;
1-5 parts of an extract of yarrow;
0.5 to 2 parts of carboxymethyl chitosan.
The preparation raw materials of the repairing and moisturizing composition also comprise sodium hyaluronate, butanediol, glycerol and water.
The repairing and moisturizing composition comprises the following raw materials in parts by weight:
0.01-0.1 parts of arginine/lysine polypeptide;
1-4 parts of an extract of marshmallow;
1-4 parts of an Eisenia variegata extract;
0.5-2 parts of industrial hemp extract;
0.5-2 parts of ectoin;
1-5 parts of Artocarpus heterophyllus extract;
1-5 parts of an extract of yarrow;
0.5 to 2 parts of carboxymethyl chitosan;
0.05-0.2 part of sodium hyaluronate;
1-5 parts of butanediol;
1-5 parts of glycerol;
60-90 parts of water.
Preferably, the repairing and moisturizing composition is prepared from the following raw materials in parts by weight:
0.05-0.1 part of arginine/lysine polypeptide;
2-4 parts of an extract of marshmallow;
2-4 parts of an Evodia gordonii extract;
0.5-1 part of industrial hemp extract;
0.5-1 parts of ectoin;
4-4.5 parts of Artocarpus heterophyllus extract;
4-4.5 parts of an extract of yarrow;
0.15 to 2 parts of carboxymethyl chitosan;
0.05-0.2 part of sodium hyaluronate;
1-5 parts of butanediol;
1-5 parts of glycerol;
60-90 parts of water.
More preferably, the repairing and moisturizing composition is prepared from the following raw materials in parts by weight:
0.05 part of arginine/lysine polypeptide;
2 parts of marshmallow extract;
2 parts of an extract of gomisia meyeriana;
1 part of industrial hemp extract;
1 part of ectoin;
4 parts of Artocarpus heterophyllus extract;
4 parts of an extract of milfoil;
0.15 part of carboxymethyl chitosan;
0.15 part of sodium hyaluronate;
3 parts of butanediol;
4 parts of glycerol;
80 parts of water.
The second part of the invention is to provide a preparation method of the repairing and moisturizing composition, which comprises the following steps:
1) dissolving sodium hyaluronate, glycerol and butanediol in water, stirring and heating to obtain a base material;
2) adding arginine/lysine polypeptide, Althaea officinalis extract, Eimeria meyeriana extract, Cannabis sativa extract, ectoine, Artocarpus meyeriana extract, Achillea millefolium extract, and carboxymethyl chitosan into the base material, and stirring.
In the step 1), the heating temperature is 70-80 ℃, and preferably 70 ℃; the heating time is 20-30 min; the stirring speed is 60-80 r/min, preferably 80 r/min.
In step 2), the arginine/lysine polypeptide, the marshmallow extract, the mairei extract, the industrial hemp extract, the ectoin, the millettia extract, the milfoil extract and the carboxymethyl chitosan are added at a temperature of 40-50 ℃, preferably 40 ℃; the stirring speed is 60-80 r/min, preferably 80 r/min.
The third part of the invention is to provide the application of the repairing and moisturizing composition in medical cosmetics, including the application in preparing repairing stock solution, eye essence, freeze-dried powder, repairing and moisturizing mask, medical dressing and the like.
The addition amount of the repairing and moisturizing composition in the medicinal cosmetics is 50-70 wt%.
The cosmeceutical may include one or more compatible, cosmetically acceptable adjuvants commonly used and known to those skilled in the art, such as antioxidants, depigmenting agents, film formers, light stabilizers, sunscreens, stabilizers, surfactants, solubilizers, emollients, thickeners, preservatives, humectants, fragrances and the like.
Compared with the prior art, the invention has the following beneficial effects:
(1) the repairing and moisturizing composition disclosed by the invention can be used for repairing and moisturizing the skin from inside and outside at the same time, so that the long-acting strengthening of the skin barrier is realized.
(2) The repairing and moisturizing composition disclosed by the invention is simple in preparation process and wide in application.
Drawings
FIG. 1 shows the results of HaCaT cell migration-promoting activity assay of a repairing and moisturizing composition at a concentration of 80% (V/V);
FIG. 2 shows the result of HaCaT cell migration activity test of the repairing and moisturizing composition at a concentration of 40% (V/V).
Detailed Description
The present invention is further described below by way of specific examples, but the present invention is not limited to only the following examples. Variations, combinations, or substitutions of the invention, which are within the scope of the invention or the spirit, scope of the invention, will be apparent to those of skill in the art and are within the scope of the invention.
In the following examples, the cosmetic ingredients were conventional commercially available ingredients unless otherwise specified.
The repairing and moisturizing composition comprises the following raw materials in the formula shown in the following table 1:
TABLE 1 EXAMPLES 1 TO 4 raw material formulas of repairing and moisturizing compositions
For comparison, comparative examples 1 to 4 of the raw material ratios as shown in table 2 are also provided below. Comparative examples 1 to 4 compared to example 1, carboxymethyl chitosan, marshmallow extract, maidenhair extract and ectoin were omitted, respectively.
Table 2, raw material formulas of repairing and moisturizing compositions of comparative examples 1 to 4
The preparation method of the repairing and moisturizing composition comprises the following steps:
1) the raw materials are weighed according to the proportion and are ready for use.
2) Sequentially adding sodium hyaluronate, glycerol and butanediol into water, stirring at a rotating speed of 80r/min, heating to 70 ℃, keeping the temperature of 70 ℃ for 25min to form a uniform base material, and then cooling to 40 ℃.
3) Adding arginine/lysine polypeptide, Althaea officinalis extract, Eimeria meyeriana extract, Cannabis sativa extract, ectoin, Artocarpus mollissima extract, and carboxymethyl chitosan into the cooled base material, stirring at 80r/min, discharging, and packaging.
Performance testing
The compositions of examples 1-4 and comparative examples 1-4 were tested for performance as follows:
first, repair ability test (HaCaT cell migration activity test)
1. Test materials:
the compositions obtained in examples 1 to 4 and comparative examples 1 to 4 were filtered through a 0.22 μm filter.
2. The test method comprises the following steps:
HaCaT cell migration was tested using 24-well culture plates and transwell chambers (8 μm wells; Corning, U.S. A.). HaCaT cells were cultured in culture flasks. When the bottle bottom is full, the cell density of the digested cells is 2 multiplied by 105Single cell suspension of individual cells, suspended in DMEM medium (without serum), was added to each upper chamber (100. mu.L/well). Then, the cells were divided into 4 groups of 3 wells, a control group and an experimental group. Each composition was tested at a concentration of 80% and 40% (V/V, volume fraction), physiological saline and each composition at different concentrations were added to the corresponding lower chamber (600. mu.L/well), and incubated at 37 ℃ for 24 hours. On the upper surface of the chamber, non-migrating cells are carefully removed. Fixing the cells with methanol for 20min, staining with 0.1% crystal violet for 20min, eluting the stained cells, measuring the absorbance by enzyme labeling, and measuring the OD at 570 nm.
The test results are shown in fig. 1 and 2. The results show that: compared with a normal saline control, the examples 1 to 4 obviously increase the migration number of HaCaT cells, and have certain concentration dependence, which shows that the composition can promote the migration capacity of keratinocytes. After the composition of comparative examples 1 to 4 is added, the keratinocyte migration capacity under high concentration is equivalent to that of normal saline, and is obviously lower than the test results of examples 1 to 4, which shows that the arginine/lysine polypeptide, the marshmallow extract, the meyerba extract, the industrial hemp extract, the ectoine, the millettia extract, the milfoil extract and the carboxymethyl chitosan of the invention can play a role in promoting keratinocyte migration only by being matched with various raw materials, and the effect cannot be achieved by the lack of any one of the raw materials.
Moreover, in examples 1 to 4, example 1 exhibited the best performance and had the best keratinocyte migration promoting ability, indicating that arginine/lysine polypeptide, marshmallow extract, meyerba extract, industrial hemp extract, ectoine, millettia extract, yarrow extract and carboxymethyl chitosan exhibited the best synergistic effect under the formulation of example 1. As can be seen from the formulations of examples 1 to 4, the formulation of example 1 slightly increased the amount of the illipe, millettia and yarrow extracts and slightly decreased the amount of ectoine compared to example 4, resulting in an increase in the keratinocyte migration-promoting ability of about 11% at 80% addition and about 13% at 40% addition. Although the amount of the extract of yarrow is significantly increased in example 3 compared to example 4, the result is not changed compared to example 4. Similarly, example 1 increased marshmallow extract and milfoil extract and decreased millettia extract compared to example 2, with a significant change in the ability to promote keratinocyte migration; in examples 3 and 4, the amount of the plant extract was increased or decreased compared to example 2, and as a result, the ability to promote the migration of keratinocytes was not changed. The proportion of the raw materials has important influence on the performance of the composition, and the raw materials have the most effective synergistic promotion effect only under the specific proportion, so that the keratinocyte migration is effectively promoted, and the skin barrier is repaired. It is also assumed that, when the formulation of example 1 is finely adjusted to a small extent, for example, in the proportions of 0.05 to 0.1 part of arginine/lysine polypeptide, 2 to 4 parts of marshmallow extract, 2 to 4 parts of maidenhair extract, 0.5 to 1 part of industrial hemp extract, 0.5 to 1 part of ectoin, 4 to 4.5 parts of millettia extract, 4 to 4.5 parts of yarrow extract, and 0.15 to 2 parts of carboxymethyl chitosan, the keratinocyte migration-promoting ability similar to that of example 1 can be obtained, and the skin-repairing ability can be enhanced.
Second, moisture restoration experiment (human body evaluation test)
1. Experimenter and arrangement:
100 volunteers were recruited, aged 20-55 years, and randomly divided into 4 groups of 25 persons each. Volunteers were all persons with skin lesions or sensitive skin or impaired skin barrier or dry, itchy skin.
2. The test method comprises the following steps:
during the test period, after the face was cleaned in the morning and evening, each volunteer used the multi-effect repairing moisturizing composition prepared in examples 1-4 and comparative example 3 for four weeks. TEWL values (in g/hm) of the skin of the test subjects before and after the test, i.e. after week 0, week 2 and week42) And (6) detecting. In addition, subjects filled in post-use evaluation tables at the end of test week4, with the main indicators of moisturization and repair. And (3) recovering an evaluation table, counting and analyzing the data, and obtaining results shown in tables 3-4:
TABLE 3 subject cheek skin TEWL values (units: g/hm)2)
| Example 1 | Example 2 | Example 3 | Example 4 | Comparative example 3 | |
| Week 0 | 17.52±2.46 | 17.48±2.73 | 16.98±2.01 | 17.95±2.45 | 17.21±2.10 |
| Week 2 | 15.03±2.27 | 16.20±2.57 | 15.01±1.98 | 15.63±2.65 | 16.98±1.98 |
| Week4 | 12.05±2.36 | 14.10±2.14 | 12.85±2.35 | 13.96±2.45 | 16.20±2.34 |
TABLE 4 self-evaluation (Unit: case) of the subjects in each group after applying the Multi-Effect repairing moisturizing composition Week4
The results show that: example 1 significantly improved the TEWL values of the subject's skin at week 2 and week4, by about 14.21% and 31.22%, respectively, compared to baseline (week 0); example 2 improved TEWL values in the skin of subjects at week 2 and week4 by about 7.32% and 19.34%, respectively; example 3 significant improvement in TEWL values of subject skin at week 2 and week4, by about 11.60% and 24.32%, respectively; example 4 significantly improved the TEWL values of the subject's skin at week 2 and week4, by about 13.24% and 22.23%, respectively. Whereas comparative example 3 had no significant improvement in subject skin TEWL values at week 2 and 4, and decreased to only about 1.31% and 5.76%. The multi-effect repairing and moisturizing composition prepared by the invention can effectively reduce percutaneous water loss, repair skin barriers and improve the water-locking capacity of the skin.
In addition, based on the subject self-evaluation shown in table 2, there were multiple instances of moisturizing and healing in each example compared to comparative example 3, with example 1 being particularly prominent. The multi-effect repairing and moisturizing composition prepared according to the proportion of the embodiment 1 has good moisturizing and repairing effects.
Claims (10)
1. A composition with repairing and moisturizing effects is characterized in that: the preparation raw materials of the composition with the repairing and moisturizing effects comprise: arginine/lysine polypeptide, Althaea officinalis extract, Eisenia mexicana extract, Cannabis sativa extract, ectoin, Artocarpus heterophyllus extract, Achillea millefolium extract, and carboxymethyl chitosan.
2. The composition with repairing and moisturizing effects according to claim 1, wherein: based on the weight portion, the weight portion of the material,
the preparation raw materials of the composition with the repairing and moisturizing effects comprise:
0.01-0.1 parts of arginine/lysine polypeptide;
1-4 parts of an extract of marshmallow;
1-4 parts of an Eisenia variegata extract;
0.5-2 parts of industrial hemp extract;
0.5-2 parts of ectoin;
1-5 parts of Artocarpus heterophyllus extract;
1-5 parts of an extract of yarrow;
0.5 to 2 parts of carboxymethyl chitosan.
3. The composition with repairing and moisturizing effects according to claim 1 or 2, wherein: the preparation raw materials of the composition with the repairing and moisturizing effects also comprise sodium hyaluronate, butanediol, glycerol and water.
4. The composition with repairing and moisturizing effects according to claim 3, wherein: based on the weight portion, the weight portion of the material,
the composition with the repairing and moisturizing effects comprises the following raw materials:
0.01-0.1 parts of arginine/lysine polypeptide;
1-4 parts of an extract of marshmallow;
1-4 parts of an Eisenia variegata extract;
0.5-2 parts of industrial hemp extract;
0.5-2 parts of ectoin;
1-5 parts of Artocarpus heterophyllus extract;
1-5 parts of an extract of yarrow;
0.5 to 2 parts of carboxymethyl chitosan;
0.05-0.2 part of sodium hyaluronate;
1-5 parts of butanediol;
1-5 parts of glycerol;
60-90 parts of water.
5. The composition with repairing and moisturizing effects according to claim 4, wherein: based on the weight portion, the weight portion of the material,
the preparation raw materials of the composition with the repairing and moisturizing effects comprise:
0.05-0.1 part of arginine/lysine polypeptide;
2-4 parts of an extract of marshmallow;
2-4 parts of an Evodia gordonii extract;
0.5-1 part of industrial hemp extract;
0.5-1 parts of ectoin;
4-4.5 parts of Artocarpus heterophyllus extract;
4-4.5 parts of an extract of yarrow;
0.15 to 2 parts of carboxymethyl chitosan;
0.05-0.2 part of sodium hyaluronate;
1-5 parts of butanediol;
1-5 parts of glycerol;
60-90 parts of water.
6. A preparation method of a composition with repairing and moisturizing effects is characterized by comprising the following steps: the method comprises the following steps:
1) dissolving sodium hyaluronate, glycerol and butanediol in water, stirring and heating to obtain a base material;
2) adding arginine/lysine polypeptide, Althaea officinalis extract, Eimeria meyeriana extract, Cannabis sativa extract, ectoine, Artocarpus meyeriana extract, Achillea millefolium extract, and carboxymethyl chitosan into the base material, and stirring.
7. The method of claim 6, wherein: in the step 1), the heating temperature is 70-80 ℃.
8. The method of claim 6, wherein: in the step 2), the arginine/lysine polypeptide, the marshmallow extract, the mairei extract, the industrial hemp extract, the ectoin, the millettia extract, the milfoil extract and the carboxymethyl chitosan are added at a temperature of 40-50 ℃.
9. Use of the composition having repairing and moisturizing effects of any one of claims 1 to 5 in pharmaceutical cosmetics.
10. Use according to claim 9, characterized in that: the pharmaceutical and cosmetic comprises at least one of a repair stock solution, eye essence, freeze-dried powder, a repair moisture mask and a medical dressing.
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| CN115381745A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Acne-removing and oil-controlling composition, acne-removing and oil-controlling essence and preparation method thereof |
| CN115624501A (en) * | 2022-11-24 | 2023-01-20 | 苏州日月年世生物科技有限公司 | Skin conditioning composition |
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| CN109758378A (en) * | 2019-03-29 | 2019-05-17 | 湖南御家化妆品制造有限公司 | A kind of moisturizing, moisturizing and/or promote the composition of cell Proliferation and its cosmetics of preparation |
| CN109771352A (en) * | 2019-03-29 | 2019-05-21 | 湖南御家化妆品制造有限公司 | It is a kind of repair skin composition and its preparation cosmetics |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381745A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Acne-removing and oil-controlling composition, acne-removing and oil-controlling essence and preparation method thereof |
| CN115624501A (en) * | 2022-11-24 | 2023-01-20 | 苏州日月年世生物科技有限公司 | Skin conditioning composition |
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