CN115381745A - Acne-removing and oil-controlling composition, acne-removing and oil-controlling essence and preparation method thereof - Google Patents

Acne-removing and oil-controlling composition, acne-removing and oil-controlling essence and preparation method thereof Download PDF

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CN115381745A
CN115381745A CN202211182208.0A CN202211182208A CN115381745A CN 115381745 A CN115381745 A CN 115381745A CN 202211182208 A CN202211182208 A CN 202211182208A CN 115381745 A CN115381745 A CN 115381745A
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李占鸿
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Guangzhou Senye Biomedical Technology Co ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/73Polysaccharides
    • A61K8/737Galactomannans, e.g. guar; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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    • A61K8/9741Pteridophyta [ferns]
    • A61K8/9749Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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    • A61K2800/592Mixtures of compounds complementing their respective functions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention discloses an acne-removing and oil-controlling composition which comprises the following raw materials in parts by weight: 5-10 parts of inula flower extract, 3-6 parts of centella asiatica extract, 2-5 parts of guava extract, 1-4 parts of peony root extract, 1-3 parts of lotus leaf extract, 2-5 parts of european dryopteris fragrans extract, 1-3 parts of neem leaf extract, 1-3 parts of hairyvein agrimony extract, 1-2 parts of fibronectin and 2-6 parts of carboxymethyl chitosan. The composition with the acne removing and oil controlling effects is a main active ingredient, the essence with the acne removing, oil controlling, pore shrinking and other effects is prepared, the oil controlling and acne controlling effects of the product are enhanced through the synergistic effect of the plant polysaccharide addition modifier and the raw materials, and the using efficiency of the product is improved.

Description

Acne-removing and oil-controlling composition, acne-removing and oil-controlling essence and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an acne-removing and oil-controlling composition, an acne-removing and oil-controlling essence and a preparation method thereof.
Background
Acne is also called whelk, and is a common skin disease which is frequently seen in adolescents. Acne occurs in close relation to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reactions. After entering adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced; meanwhile, abnormal keratinization of the pilosebaceous canal causes the canal to be blocked, sebum is obstructed to be discharged, and a keratoplug, namely micro acne, is formed. A plurality of microorganisms, especially propionibacterium acnes, in hair follicles multiply massively, lipase generated by the propionibacterium acnes decomposes sebum to generate free fatty acid, and meanwhile, inflammatory cells and mediators are chemotactic, so that inflammatory reaction is finally induced and aggravated, and acne, whelk and the like are formed.
The existing acne-removing and oil-controlling product has single efficacy, and the coordination improvement of the acne-removing and oil-controlling product is difficult to realize, so that further improvement and optimization treatment are needed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an acne-removing and oil-controlling composition, an acne-removing and oil-controlling essence and a preparation method thereof, so as to solve the problems in the background technology.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the invention provides an acne-removing and oil-controlling composition which comprises the following raw materials in parts by weight:
5-10 parts of inula flower extract, 3-6 parts of asiatic pennywort herb extract, 2-5 parts of guava extract, 1-4 parts of peony root extract, 1-3 parts of lotus leaf extract, 2-5 parts of European dryopteris fragrans extract, 1-3 parts of neem leaf extract, 1-3 parts of hairyvein agrimony extract, 1-2 parts of fibronectin and 2-6 parts of carboxymethyl chitosan.
Preferably, the acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
7.5 parts of inula flower extract, 4.5 parts of centella extract, 3.5 parts of guava extract, 2.5 parts of peony root extract and 2 parts of lotus leaf extract, and 3.5 parts of compounded European dryopteris fragrans, 2 parts of neem leaf extract, 2 parts of hairyvein agrimonia herb and bud extract, 1.5 parts of fibronectin and 4 parts of carboxymethyl chitosan.
Preferably, the composition is also added with 2-5 parts of plant polysaccharide additive modifier.
The inventor finds that the antibacterial rate of the product is remarkably reduced without adding the plant polysaccharide additive modifier, and the plant polysaccharide additive modifier is matched with the raw materials to coordinate and enhance the antibacterial effect and sebum inhibition rate of the product, so that the acne-removing and oil-controlling effects of the product are improved.
Preferably, the preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 5-10 parts of guar gum polysaccharide into 10-20 parts of deionized water, then adding 2-3 parts of hydroxy amino acid and 1-4 parts of sodium alginate solution, and uniformly stirring;
s12: adding 2-5 parts of epoxypropane and 1-3 parts of citric acid into 6-10 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
Preferably, the mass fraction of the sodium alginate solution is 10-20%.
Preferably, the mass fraction of the sodium citrate solution is 15-25%.
The invention also provides a preparation method of the acne-removing and oil-controlling composition, which comprises the following steps: the raw materials are stirred and mixed fully in turn, the stirring speed is 450-550r/min, and the stirring time is 55-65min, so that the composition with the anti-hair loss effect is obtained.
The invention also provides acne-removing and oil-controlling essence comprising the composition as described in any one of claims 1 to 8.
Compared with the prior art, the invention has the following beneficial effects:
the composition with the acne removing and oil controlling effects is a main active ingredient, essence with the acne removing, oil controlling, pore shrinking and other effects is prepared, the oil controlling and acne controlling effects of the product are enhanced through synergistic effect of the plant polysaccharide addition modifier and the raw materials, and the using efficiency of the product is improved.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
5-10 parts of inula flower extract, 3-6 parts of asiatic pennywort herb extract, 2-5 parts of guava extract, 1-4 parts of peony root extract, 1-3 parts of lotus leaf extract, 2-5 parts of European dryopteris fragrans extract, 1-3 parts of neem leaf extract, 1-3 parts of hairyvein agrimony extract, 1-2 parts of fibronectin and 2-6 parts of carboxymethyl chitosan.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
7.5 parts of inula flower extract, 4.5 parts of centella extract, 3.5 parts of guava extract, 2.5 parts of peony root extract and 2 parts of lotus leaf extract, 3.5 parts of compounded European dryopteris fragrans extract, 2 parts of neem leaf extract, 2 parts of hairyvein agrimony extract, 1.5 parts of fibronectin and 4 parts of carboxymethyl chitosan.
The composition of the embodiment is also added with 2 to 5 parts of plant polysaccharide additive modifier.
The preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 5-10 parts of guar gum polysaccharide into 10-20 parts of deionized water, then adding 2-3 parts of hydroxy amino acid and 1-4 parts of sodium alginate solution, and uniformly stirring;
s12: adding 2-5 parts of epoxypropane and 1-3 parts of citric acid into 6-10 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
The mass fraction of the sodium alginate solution in the embodiment is 10-20%.
The mass fraction of the sodium citrate solution in this example is 15-25%.
The preparation method of the acne-removing and oil-controlling composition comprises the following steps: the raw materials are stirred and mixed fully in turn, the stirring speed is 450-550r/min, and the stirring time is 55-65min, so that the composition with the anti-hair loss effect is obtained.
Example 1.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
5 parts of inula flower extract, 3 parts of centella extract, 2 parts of guava extract, 1 part of peony root extract, 1 part of lotus leaf extract, 2 parts of European dryopteris fragrans, 1 part of neem leaf extract, 1 part of hairyvein agrimony extract, 1 part of fibronectin and 2 parts of carboxymethyl chitosan.
The composition of the embodiment is also added with 2 parts of plant polysaccharide additive modifier.
The preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 5 parts of guar gum polysaccharide into 10 parts of deionized water, then adding 2 parts of hydroxy amino acid and 1 part of sodium alginate solution, and uniformly stirring;
s12: adding 2 parts of propylene oxide and 1 part of citric acid into 6 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
The mass fraction of the sodium alginate solution in this example was 10%.
The mass fraction of the sodium citrate solution in this example was 15%.
The preparation method of the acne-removing and oil-controlling composition comprises the following steps: the raw materials are stirred and mixed fully in turn, the stirring speed is 450r/min, and the stirring time is 55min, so that the composition with the anti-hair loss effect is obtained.
Example 2.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
10 parts of inula flower extract, 6 parts of centella extract, 5 parts of guava extract, 4 parts of peony root extract, 3 parts of lotus leaf extract, 5 parts of European dryopteris fragrans, 3 parts of neem leaf extract, 3 parts of hairyvein agrimony extract, 2 parts of fibronectin and 6 parts of carboxymethyl chitosan.
The composition of the embodiment is also added with 5 parts of plant polysaccharide additive modifier.
The preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 10 parts of guar gum polysaccharide into 20 parts of deionized water, then adding 3 parts of hydroxy amino acid and 4 parts of sodium alginate solution, and uniformly stirring;
s12: adding 5 parts of propylene oxide and 3 parts of citric acid into 10 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
The mass fraction of the sodium alginate solution in this example was 20%.
The preparation method of the acne-removing and oil-controlling composition comprises the following steps: the raw materials are stirred and mixed fully in sequence, the stirring speed is 550r/min, and the stirring time is 65min, so that the composition with the anti-hair loss effect is obtained.
Example 3.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
7.5 parts of inula flower extract, 4.5 parts of centella extract, 3.5 parts of guava extract, 2.5 parts of peony root extract and 2 parts of lotus leaf extract, and 3.5 parts of compounded European dryopteris fragrans, 2 parts of neem leaf extract, 2 parts of hairyvein agrimonia herb and bud extract, 1.5 parts of fibronectin and 4 parts of carboxymethyl chitosan.
The composition of the embodiment is also added with 3.5 parts of plant polysaccharide additive modifier.
The preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 7.5 parts of guar gum polysaccharide into 15 parts of deionized water, then adding 2.5 parts of hydroxy amino acid and 2.5 parts of sodium alginate solution, and uniformly stirring;
s12: adding 3.5 parts of propylene oxide and 2 parts of citric acid into 8 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
The mass fraction of the sodium alginate solution in this example was 15%.
The mass fraction of the sodium citrate solution in this example was 20%.
The preparation method of the acne-removing and oil-controlling composition comprises the following steps: the raw materials are stirred and mixed fully in sequence, the stirring speed is 500r/min, and the stirring time is 60min, so that the composition with the anti-hair loss effect is obtained.
Example 4.
The acne-removing and oil-controlling composition comprises the following raw materials in parts by weight:
6 parts of inula flower extract, 4 parts of centella extract, 3 parts of guava extract, 2 parts of peony root extract, 2 parts of lotus leaf extract, 3 parts of European dryopteris fragrans, 2 parts of neem leaf extract, 2 parts of hairyvein agrimony extract, 1.2 parts of fibronectin and 3 parts of carboxymethyl chitosan.
The composition of the embodiment is also added with 3 parts of plant polysaccharide additive modifier.
The preparation method of the plant polysaccharide additive modifier comprises the following steps:
s11: adding 6 parts of guar gum polysaccharide into 12 parts of deionized water, then adding 2.2 parts of hydroxy amino acid and 2 parts of sodium alginate solution, and uniformly stirring;
s12: adding 3 parts of propylene oxide and 2 parts of citric acid into 7 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
The mass fraction of the sodium alginate solution in this example was 12%.
The mass fraction of the sodium citrate solution in this example was 18%.
The preparation method of the acne-removing and oil-controlling composition comprises the following steps: the raw materials are stirred and mixed fully in turn, the stirring speed is 460r/min, and the stirring time is 58min, so that the composition with the anti-hair loss effect is obtained.
Comparative example 1.
The difference from the example 3 is that no plant polysaccharide is added with a modifier.
Comparative example 2.
The difference from the example 3 is that no additive is added in the preparation of the plant polysaccharide addition modifier.
Propionibacterium acnes bacteriostasis test
According to a culture medium for operation of 'cosmetic hygiene standards' 2015 edition, a bacterial liquid preparation method and an inoculation method, propionibacterium acnes bacteriostasis tests are carried out on products prepared in experimental examples 1-4 and comparative examples 1-2, the bacteriostasis results are expressed by bacteriostasis rates, the higher the bacteriostasis rate is, the better the bacteriostasis effect of the skin care product is proved, and the lower the bacteriostasis rate is, the worse the bacteriostasis effect of the skin care product is proved.
The age of the selected test population is 15-35 years old and 100 people in total, each group comprises 10 people, half of men and women, the face has obvious acnes and acnes, the test population accords with the volunteer selection standard of the subject, the test population is continuously used for 14 days for 2 times every day, and other skin care products or hormone products cannot be used in the test process. The sebum value is measured after 14 days by the test person return using the SM815 test method with the model number of Courage-Khazaka Germany, the treatment effect is recorded, and the sebum value reduction value is obtained by subtracting the sebum value before use from the sebum value after 14 days.
The performance of the products of examples 1-4 and comparative examples 1-2 was tested as follows:
Figure 678189DEST_PATH_IMAGE001
as can be seen from comparative examples 1-2 and examples 1-4;
according to the invention, no plant polysaccharide additive modifier is added, the bacteriostatic rate of the product is obviously reduced, the plant polysaccharide additive modifier is matched, the raw materials are coordinated and synergized, the bacteriostatic effect and sebum inhibition rate of the product are enhanced, and the acne-removing and oil-controlling effect of the product is improved.
The composition is a main active ingredient, the essence with the effects of removing acnes, controlling oil, shrinking pores and the like is prepared, and the oil control and acne removal effects of the product are enhanced and the using efficiency of the product is improved through synergistic effect between the plant polysaccharide addition modifier and the raw materials.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (8)

1. The acne-removing and oil-controlling composition is characterized by comprising the following raw materials in parts by weight:
5-10 parts of inula flower extract, 3-6 parts of asiatic pennywort herb extract, 2-5 parts of guava extract, 1-4 parts of peony root extract, 1-3 parts of lotus leaf extract, 2-5 parts of European dryopteris fragrans extract, 1-3 parts of neem leaf extract, 1-3 parts of hairyvein agrimony extract, 1-2 parts of fibronectin and 2-6 parts of carboxymethyl chitosan.
2. The acne-removing and oil-controlling composition according to claim 1, which comprises the following raw materials in parts by weight:
7.5 parts of inula flower extract, 4.5 parts of centella extract, 3.5 parts of guava extract, 2.5 parts of peony root extract and 2 parts of lotus leaf extract, and 3.5 parts of compounded European dryopteris fragrans, 2 parts of neem leaf extract, 2 parts of hairyvein agrimonia herb and bud extract, 1.5 parts of fibronectin and 4 parts of carboxymethyl chitosan.
3. The composition for removing acne and controlling oil according to claim 1, wherein 2-5 parts of plant polysaccharide additive modifier is further added into the composition.
4. The composition for removing acne and controlling oil according to claim 3, wherein the plant polysaccharide additive modifier is prepared by the following steps:
s11: adding 5-10 parts of guar gum polysaccharide into 10-20 parts of deionized water, then adding 2-3 parts of hydroxy amino acid and 1-4 parts of sodium alginate solution, and uniformly stirring;
s12: adding 2-5 parts of epoxypropane and 1-3 parts of citric acid into 6-10 parts of sodium citrate solution to obtain an additive;
s13: and (3) adding the additive of the S12 into the S11, and fully stirring and mixing to obtain the plant polysaccharide additive modifier.
5. The composition for removing acne and controlling oil according to claim 4, wherein the mass fraction of the sodium alginate solution is 10-20%.
6. The composition for removing acne and controlling oil according to claim 4, wherein the mass fraction of the sodium citrate solution is 15-25%.
7. A method for preparing the acne-removing and oil-controlling composition according to any one of claims 1 to 6, which comprises the following steps: the raw materials are stirred and mixed fully in turn, the stirring speed is 450-550r/min, and the stirring time is 55-65min, so that the composition with the anti-hair loss effect is obtained.
8. An acne-removing and oil-controlling essence characterized by comprising the composition according to any one of claims 1 to 7.
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