CN114533647B

CN114533647B - Silicone oil-free anti-dandruff shampoo composition and preparation method thereof

Info

Publication number: CN114533647B
Application number: CN202210337357.3A
Authority: CN
Inventors: 陈漫丽; 谭志标; 曾苑玲; 莫远善
Original assignee: Guangzhou Xuzhuang Biotechnology Co ltd
Current assignee: Guangzhou Xuzhuang Biotechnology Co ltd
Priority date: 2022-03-31
Filing date: 2022-03-31
Publication date: 2023-06-16
Anticipated expiration: 2042-03-31
Also published as: CN114533647A

Abstract

The invention relates to the field of daily necessities, and provides a silicone oil-free anti-dandruff shampoo composition and a preparation method thereof. The silicone oil-free anti-dandruff shampoo composition comprises the following components in parts by weight: 8-40 parts of surfactant and 5.2-25 parts of efficacy component; the efficacy components of 5.2 to 25 parts comprise 0.2 to 5 parts of pseudoalteromonas fermentation product, 1 to 10 parts of peony seed oil microemulsion, 1 to 10 parts of sweet wormwood extract microemulsion, wherein the content of the peony seed oil in the peony seed oil microemulsion is 5 to 20 weight percent, and the content of the sweet wormwood extract in the sweet wormwood extract microemulsion is 5 to 20 weight percent. The preparation method comprises the following steps: the components are mixed uniformly. The shampoo composition uses the pseudoalteromonas fermentation product extract to avoid the defects of the traditional anti-dandruff agent, uses natural peony seed oil and sweet wormwood herb extract as a natural substitute of silicone oil, is environment-friendly, avoids the accumulation of the silicone oil on hair, simultaneously has the functions of resisting oxidation, bacteria and inflammation, maintains the health of the whole scalp, and obviously improves the dandruff condition of a user within a 28-day period of testing.

Description

Silicone oil-free anti-dandruff shampoo composition and preparation method thereof

Technical Field

The invention relates to the field of daily necessities, in particular to a silicone oil-free anti-dandruff shampoo composition and a preparation method thereof.

Background

The European Union committee officially submitted the G/TBT/N/EU/773 notice to the world trade organization at 22, 1, 2021. This announcement is a flat ground surprise and is expected to affect most of the commercially available anti-dandruff shampoos. The commonly used antidandruff ingredient ZPT was announced to be listed as CMR 1B substance (based on animal studies presuming carcinogenic, mutagenic, teratogenic effects to humans). The european union has updated regulations relating to european union cosmetic regulations (EC) No 1223/2009 annex II, annex III and annex V with respect to upcoming CMR substances such as zinc pyrithione, revised published european union publication (EU) 2021/1902, month 11, month 3 of 2021. Zinc Pyrithione, INCI name Zinc Pyrithione (ZPT), CAS No. 13463-41-7, is currently an authorized preservative for cosmetics and a non-preservative target substance for use in the european union, and is governed by the european union's cosmetic regulations annex V clause 8 and annex III clause 101, respectively. Due to the presence of reproductive toxicity ZPT was defined by the european commission grant regulations (EU) No 2020/1182 as a class 1B reproductive toxic substance, triggering regulations regarding the prohibition of CMR substances for cosmetic use. SCCS is indicated in the opinion regarding zinc pyrithione that ZPT at a concentration of 1% is safe as an antidandruff ingredient when used in rinse-off hair products. However, there is no evidence that the rinse-off hair product does not have a suitable anti-dandruff ingredient substitute, and ZPT cannot meet the requirement of "no suitable alternative" in the conditions for exempting the CMR substance, and therefore does not meet the rule for exempting the CMR substance.

For the reasons described above, the european union decided to add ZPT as a forbidden substance to the european union cosmetic regulation annex II regulations, while deleting the relevant regulations of annex III clause 101 and annex V clause 8 with respect to that substance, administered since 2022, 3, 1.

OCT which can play a role in removing dandruff and inhibiting bacteria is limited in use due to unstable products all the time because of easy discoloration and oxidation. In addition, long-term use of OCT and ZPT causes malassezia furfur resistance, resulting in poor long-term anti-dandruff effects.

The single use efficiency of the gamboge is low, the overall cost performance is low, and the gamboge is coordinated and synergistic by matching with ZPT when in use, so that the gamboge has a limit in later use.

Hexamidine di (isethionate) salt has the functions of sterilization and itching relieving, but has the defects of high price and low cost performance, so that the common shampoo is prohibitive.

In addition, salicylic acid, jiao Youlei and sulfur products have different defects, jiao Youlei and the sulfur smell has strong color and is rarely used for daily hair washing and caring products. However, long-term use of the shampoo containing salicylic acid can damage skin barrier of scalp, and symptoms such as dizziness, tinnitus and nausea can occur seriously.

On the other hand, because of the water impermeability and inertness of the silicone oil, the silicone oil which cannot be washed away can be blocked at the scalp, so that the silicone oil remains and accumulates, and scalp itching and dandruff falling are caused. In recent years, the EU has paid attention to the environmental protection of silicone oil, and the rinsed silicon-containing components pollute the environment, so that the EU is also subject to legislative restrictions on part of the silicone oil.

In view of this, the present application is specifically proposed.

Disclosure of Invention

The invention aims at providing a silicone oil-free anti-dandruff shampoo composition and a preparation method thereof, which have good anti-dandruff, scalp-protecting and hair-care effects.

In a first aspect, the invention provides a silicone oil-free anti-dandruff shampoo composition, which comprises the following components in parts by weight: 8-40 parts of surfactant and 5.2-25 parts of efficacy component;

5.2-25 parts of the efficacy components comprise 0.2-5 parts of a pseudoalteromonas fermentation product, 1-10 parts of peony seed oil microemulsion and 1-10 parts of sweet wormwood extract microemulsion, wherein the content of the peony seed oil in the peony seed oil microemulsion is 5-20wt%, and the content of the sweet wormwood extract in the sweet wormwood extract microemulsion is 5-20wt%.

In an alternative embodiment, the silicone oil-free anti-dandruff shampoo composition comprises the following components in parts by weight: 10-20 parts of surfactant and 7-21 parts of efficacy component; 7-21 parts of the efficacy components comprise 2-10 parts of peony seed oil microemulsion, 2-10 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

In an alternative embodiment, the silicone oil-free anti-dandruff shampoo composition comprises the following components in parts by weight: 10-20 parts of surfactant and 10-12 parts of efficacy component; 10-12 parts of efficacy components comprise 3-5 parts of peony seed oil microemulsion, 3-5 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

In an alternative embodiment, the silicone oil free anti-dandruff shampoo composition further comprises, in parts by weight: 0.2-2 parts of thickener.

In an alternative embodiment, the thickener comprises at least one of hydroxyethyl cellulose, carbomer, hydroxypropyl methylcellulose, hydroxypropyl cellulose, and microcrystalline cellulose.

In an alternative embodiment, the silicone oil-free anti-dandruff shampoo composition further comprises 0.1 to 0.5 parts by weight of a conditioning agent.

In an alternative embodiment, the conditioning agent comprises at least one of cationic guar gum, coco trimethyl ammonium chloride, dihydroxypropyl PEG-5 lino ammonium chloride, polyquaternium-10, quaternium-82, polyquaternium-67, dioleoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, trimethylolpropane trioctanoate/triodecanoate, hydrolyzed silk, and hydrolyzed wheat protein.

In an alternative embodiment, the components of the composition further comprise 0.001-1 part by weight of a pH regulator.

In an alternative embodiment, the pH adjuster includes at least one of citric acid, sodium citrate, sodium lactate, sodium hydroxide, arginine, potassium hydroxide, and lactic acid.

In an alternative embodiment, the components further comprise 0.001 to 1 part of preservative in parts by weight.

In alternative embodiments, the preservative comprises at least one of benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, sodium salicylate, methyl chloroisothiazolinone, methyl isothiazolinone, sodium benzoate, potassium sorbate, and hydantoin.

In an alternative embodiment, the silicone oil free anti-dandruff shampoo composition further comprises from 0.02 to 0.3 parts by weight of a chelating agent.

More preferably, the chelating agent includes at least one of EDTA-2Na, EDTA-4Na, tetrasodium glutamate diacetate, octanoyl hydroxamic acid, and p-hydroxyacetophenone.

In an alternative embodiment, the surfactant comprises at least one of sodium lauroyl sarcosinate, disodium lauroyl amphodiacetate, propylene glycol laurate, cocamide MEA, sodium myristoyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glycinate, sodium laureth sulfate, sodium cocoyl aminopropionate, sodium lauroyl amphoacetate, cocamidopropyl betaine, disodium laureth sulfosuccinate, sodium cocoyl amphoacetate, trideceth-3, sodium trideceth sulfate, sodium lauryl hydroxysulfobetaine, sodium methyl cocoyl taurate, sodium laureth carboxylate, and sodium cocoyl-glucoside tartrate.

In an alternative embodiment, the preparation raw materials of the peony seed oil microemulsion comprise the following components in percentage by mass:

peony seed oil 5-20%, stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate 0.001-0.1%, tridecyl alcohol polyether sodium sulfate 10-40%, tridecyl alcohol polyether-3.1-3%, sodium chloride 2-5%, and water in balance.

In an alternative embodiment, the preparation method of the peony seed oil microemulsion comprises the following steps:

stirring peony seed oil and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at a constant temperature in a water bath at 75-85 ℃ for 10-20 min, and then continuing to carry out ultrasonic treatment until no-particle transparent liquid is obtained under the water bath condition to obtain a first mixed liquid;

stirring trideceth sodium sulfate, trideceth-3, sodium chloride and water in a water bath at a constant temperature of 75-85 ℃ until no uniform liquid is produced, and obtaining a second mixed liquid;

at 55-65 ℃, the first mixed solution and the second mixed solution are mixed and stirred uniformly, and then the mixture is placed in a dispersing machine for uniform homogenization and dispersion to obtain a third mixed solution;

and (3) treating the third mixed solution at least once by adopting a high-pressure homogenizer at 40-120 MPa to obtain the peony seed oil microemulsion.

In an alternative embodiment, the second mixed solution is obtained by stirring at constant temperature for 20 to 30 minutes.

In an alternative embodiment, the disperser homogenizing conditions are: the rotation speed of the IKA T25 disperser is 8000-14000 r/min, and the dispersing time is 5-10 min.

In an alternative embodiment, the high pressure homogenizer is treated between 3 and 5 times.

In an alternative embodiment, the preparation raw materials of the sweet wormwood herb extract microemulsion comprise the following components in percentage by mass:

5 to 20 percent of sweet wormwood herb extract, 0.001 to 0.1 percent of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 10 to 40 percent of tridecyl alcohol polyether sodium sulfate, 0.1 to 3 percent of tridecyl alcohol polyether-3, 2 to 5 percent of sodium chloride and the balance of water.

In an alternative embodiment, the method for preparing the sweet wormwood extract microemulsion comprises the following steps:

stirring the sweet wormwood extract and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at a constant temperature in a water bath at 75-85 ℃ for 10-20 min, and then continuing to carry out ultrasonic treatment under the water bath condition until no particle transparent liquid is obtained to obtain a fourth mixed solution;

stirring trideceth sodium sulfate, trideceth-3, sodium chloride and water in a water bath at a constant temperature of 75-85 ℃ until no uniform liquid is produced, and obtaining a fifth mixed liquid;

mixing and stirring the fourth mixed solution and the fifth mixed solution uniformly at 55-65 ℃, and then placing the mixture into a dispersing machine for homogenizing and dispersing uniformly to obtain a sixth mixed solution;

And (3) treating the sixth mixed solution at least once by adopting a high-pressure homogenizer at 40-120 MPa to obtain the sweet wormwood extract microemulsion.

In an alternative embodiment, the fifth mixed solution is obtained by stirring at constant temperature for 20 to 30 minutes.

In a second aspect, the present invention provides a method for preparing a silicone oil-free anti-dandruff shampoo composition, for preparing the silicone oil-free anti-dandruff shampoo composition, comprising: the components are mixed uniformly.

The beneficial effects of the embodiment of the invention include:

the silicone oil-free anti-dandruff shampoo composition provided by the application has the advantages that the defect of the traditional anti-dandruff agent is avoided by using the pseudoalteromonas fermentation product extract, the natural peony seed oil is used as a natural substitute of the silicone oil, the silicone oil-free anti-dandruff shampoo composition is environment-friendly, the accumulation of the silicone oil on hair is avoided, meanwhile, the effects of antioxidation, antibiosis and anti-inflammatory are brought, the health of the whole scalp is maintained, and the dandruff condition of a user is obviously improved in a 28-day period of testing.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

The silicone oil-free anti-dandruff shampoo composition and the preparation method thereof provided by the embodiment of the invention are described in detail below.

The silicone oil-free anti-dandruff shampoo composition provided by the embodiment of the application comprises the following components in parts by weight: 8-40 parts of surfactant and 5.2-25 parts of efficacy component;

the efficacy components of 5.2 to 25 parts comprise 0.2 to 5 parts of pseudoalteromonas fermentation product, 1 to 10 parts of peony seed oil microemulsion, 1 to 10 parts of sweet wormwood extract microemulsion, wherein the content of the peony seed oil in the peony seed oil microemulsion is 5 to 20 weight percent, and the content of the sweet wormwood extract in the sweet wormwood extract microemulsion is 5 to 20 weight percent.

Specific components of the silicone oil-free anti-dandruff shampoo composition may be:

for example: 8 parts of surfactant, 25 parts of efficacy components and 25 parts of efficacy components, wherein the efficacy components comprise 10 parts of peony seed oil microemulsion, 10 parts of sweet wormwood extract microemulsion and 5 parts of pseudoalteromonas fermentation products;

Or 40 parts of surfactant, 5.2 parts of efficacy component and 5.2 parts of efficacy component comprise 1 part of peony seed oil microemulsion, 1 part of sweet wormwood extract microemulsion and 3.2 parts of pseudoalteromonas fermentation product;

or, the 10 parts of the surfactant, the 5.2 parts of the functional components and the 5.2 parts of the functional components comprise 2 parts of peony seed oil microemulsion, 3 parts of sweet wormwood extract microemulsion and 0.2 part of pseudoalteromonas fermentation product;

or 20 parts of surfactant, 10 parts of efficacy component and 10 parts of efficacy component comprise 4 parts of peony seed oil microemulsion, 5 parts of sweet wormwood extract microemulsion and 1 part of pseudomonas fermentation product.

The silicone oil anti-dandruff shampoo composition provided by the application has the following advantages:

1. the addition of the fermentation product of the pseudoalteromonas can inhibit the number of malassezia furfur on scalp to play a role in removing dandruff and protecting hair follicles, and compared with OCT and ZPT, the fermentation product is more difficult to cause malassezia furfur to generate drug resistance, environmental and deformity risks caused by the traditional anti-dandruff agent ZPT are avoided, the fermentation product is not oxidized as easily as OCT, and the problem that the traditional OCT shampoo is easy to change color is solved;

2. the natural peony seed oil and the sweet wormwood extract are added into the composition to serve as substitutes of silicone oil, so that the composition is environment-friendly, the silicone oil is prevented from accumulating on hair, and meanwhile, the peony seed oil and the sweet wormwood extract also have the functions of resisting oxidation, resisting bacteria and resisting inflammation;

3. The inventor finds that the pseudomonas fermentation product, the peony seed oil and the sweet wormwood extract are matched in a proper proportion for use, so that the sweet wormwood extract has a better anti-dandruff effect and can generate a synergistic effect. The synergy of the three components not only avoids the problem of low cost performance of hexamidine di (hydroxyethyl sulfonic acid) salt, but also eliminates the problem of strong and pungent smell of tar and sulfur; in addition, the composition has the advantages of nature, mildness and low stimulation, avoids the damage of salicylic acid to scalp skin barrier and human body, and can greatly improve the sterilizing and dandruff removing efficiency compared with the glycyrhizite;

4. because peony seed oil and sweet wormwood extract belong to oily substances, the viscosity of the shampoo composition can be reduced by directly adding the composition, so that the shampoo composition has slow foaming, less foam and poor use experience, in addition, the sweet wormwood extract is directly added, the unstable problem can occur at low temperature, the sweet wormwood oil can be solidified, semisolid particles are suspended in the shampoo to influence the appearance, and if the water-soluble extract is directly used, although the water-soluble peony and sweet wormwood extract have good water solubility, the water-soluble peony and sweet wormwood extract can be directly washed in the shampoo process, the amount attached to hair or scalp is very little, and the shampoo is basically ineffective. The invention uses oil-soluble extract, and the surfactant adopted in the preparation of the microemulsion can emulsify high-content grease due to the structural characteristics of the surfactant, and has the advantages of no influence on foaming, high stability and good mildness. Therefore, in the application, besides the problems can be avoided, when the two substances are added into the composition in the form of the microemulsion, the microemulsion can be blocked in gaps of hair scales and adsorbed on scalp, and after the microemulsion is rubbed and leached, the active components of the microemulsion are released, so that the antibacterial, antioxidant and anti-inflammatory effects are exerted on the scalp, the hair care effect can be achieved, and the effect of the hair care composition is greatly improved compared with that of the water-soluble extract.

In summary, the silicone oil-free anti-dandruff shampoo composition provided by the application comprises the pseudomonas fermentation product, the peony seed oil microemulsion and the sweet wormwood extract microemulsion, the defect of the traditional anti-dandruff agent is avoided by using the pseudomonas fermentation product extract, the natural peony seed oil and the sweet wormwood extract as natural substitutes of the silicone oil are environment-friendly, the accumulation of the silicone oil on hair is avoided, meanwhile, the effects of antioxidation, antibiosis and anti-inflammatory are brought, the health of the whole scalp is maintained, and the dandruff condition of a user is obviously improved within a 28-day period of testing. The synergistic effect of the pseudomonas fermentation product, the peony seed oil microemulsion and the sweet wormwood extract microemulsion can play a role in long-acting dandruff removal, scalp protection and hair care.

Preferably, to further ensure that the silicone oil-free anti-dandruff shampoo composition has better effect, the components of the silicone oil-free anti-dandruff shampoo composition comprise, in parts by weight: 10-20 parts of surfactant and 7-21 parts of efficacy component; the efficacy components of 7-21 parts comprise 2-10 parts of peony seed oil microemulsion, 2-10 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

For example: 10 parts of surfactant, 7 parts of efficacy components and 7 parts of efficacy components, wherein the efficacy components comprise 3 parts of peony seed oil microemulsion, 3 parts of sweet wormwood extract microemulsion and 1 part of pseudoalteromonas fermentation product;

Or 20 parts of surfactant, 15 parts of efficacy components and 15 parts of efficacy components, wherein the efficacy components comprise 10 parts of peony seed oil microemulsion, 3 parts of sweet wormwood extract microemulsion and 2 parts of pseudoalteromonas fermentation product;

or 15 parts of surfactant, 17 parts of efficacy component and 17 parts of efficacy component comprise 4 parts of peony seed oil microemulsion, 10 parts of sweet wormwood extract microemulsion and 3 parts of pseudomonas fermentation product.

More preferably, to further ensure that the silicone oil-free anti-dandruff shampoo composition has better effect, the components of the silicone oil-free anti-dandruff shampoo composition comprise, in parts by weight: 10-20 parts of surfactant and 10-12 parts of efficacy component; 10-12 parts of efficacy components comprise 3-5 parts of peony seed oil microemulsion, 3-5 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

Specifically, the surfactant includes at least one of sodium lauroyl sarcosinate, disodium lauroyl amphodiacetate, propylene glycol laurate, cocamide MEA, sodium myristoyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glycinate, sodium laureth sulfate, sodium cocoyl aminopropionate, sodium lauroyl amphodiacetate, cocamidopropyl betaine, disodium laureth sulfosuccinate, sodium cocoyl amphodiacetate, trideceth-3, trideceth sodium sulfate, sodium lauryl hydroxysulfobetaine, sodium methyl cocoyl taurate, sodium laureth carboxylate, and sodium cocoyl-glucoside tartrate. The surfactant is selected to have excellent foaming and low skin irritation and high detergency.

Preferably, the shampoo composition further comprises 0.2-2 parts by weight of a thickener for increasing the viscosity of the shampoo composition.

Specifically, the high molecular thickener comprises at least one of hydroxyethyl cellulose, carbomer, hydroxypropyl methylcellulose, hydroxypropyl cellulose and microcrystalline cellulose.

Preferably, the shampoo composition further comprises 0.1-0.5 parts by weight of conditioning agent. The conditioning agent in the composition in a suitable amount can condition the softness, combing property and smoothness of hair.

Specifically, the conditioning agent comprises at least one of cationic guar gum, coco trimethyl ammonium chloride, dihydroxypropyl PEG-5 linolic ammonium chloride, polyquaternium-10, quaternium-82, polyquaternium-67, dioleoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, trimethylolpropane trioctanoate/triodecanoate, hydrolyzed silk and hydrolyzed wheat protein.

Preferably, the shampoo composition further comprises 0.001-1 part by weight of pH regulator. The pH regulator is used for regulating the pH value of the shampoo composition, so that the pH value of the shampoo composition is in a proper range.

Specifically, the pH regulator includes at least one of citric acid, sodium citrate, sodium lactate, sodium hydroxide, arginine, potassium hydroxide, and lactic acid.

Preferably, the shampoo composition further comprises 0.001-1 part of preservative in parts by weight. The addition of appropriate amount of antiseptic can prolong shelf life of shampoo composition.

Specifically, the preservative comprises at least one of benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, sodium salicylate, methyl chloroisothiazolinone, methyl isothiazolinone, sodium benzoate, potassium sorbate and hydantoin.

Preferably, the shampoo composition further comprises 0.02-0.3 parts by weight of a chelating agent to the system.

Specifically, the chelating agent comprises at least one of EDTA-2Na, EDTA-4Na, tetrasodium glutamate diacetate, octanoyl hydroxamic acid and p-hydroxyacetophenone.

Preferably, the preparation raw materials of the peony seed oil microemulsion comprise the following components in percentage by mass:

For example: 5% of peony seed oil, 0.001% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 40% of tridecyl alcohol polyether sodium sulfate, 3% of tridecyl alcohol polyether-3, 2% of sodium chloride and the balance of water;

Or 20% of peony seed oil, 0.1% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 10% of tridecyl alcohol polyether sodium sulfate, 0.1% of tridecyl alcohol polyether-3, 5% of sodium chloride and the balance of water;

or 10% of peony seed oil, 0.01% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 20% of tridecyl alcohol polyether sodium sulfate, 1% of tridecyl alcohol polyether-3, 4% of sodium chloride and the balance of water;

or, peony seed oil 15%, stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate 0.05%, tridecyl alcohol polyether sodium sulfate 30%, tridecyl alcohol polyether-3 2%, sodium chloride 3% and the balance of water.

Further, in order to obtain stable peony seed oil microemulsion, the preparation method of the peony seed oil microemulsion comprises the following steps:

the first step: stirring peony seed oil and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at constant temperature under water bath of 75-85 ℃ (for example: 75 ℃, 80 ℃ or 85 ℃) for 10-20 min (for example, 10min, 15min or 20 min), and then continuing to carry out ultrasonic treatment under water bath condition until no particle transparent liquid is obtained to obtain a first mixed liquid.

And a second step of: stirring the trideceth sodium sulfate, the trideceth-3 and water in a water bath with a temperature of 75-85 ℃ (for example, 75 ℃, 80 ℃ or 85 ℃) for about 20-30 min (for example, 20min, 25min or 30 min) until no particles are uniform, and obtaining a second mixed solution.

And a third step of: the first mixed solution and the second mixed solution are mixed and stirred uniformly at 55-65 ℃ (for example, 55 ℃, 60 ℃ or 65 ℃), then the mixture is placed in an IKA T25 dispersing machine, and the third mixed solution is obtained by dispersing under the conditions of 8000-14000 revolutions per minute and 5-10 minutes (for example, 5 minutes, 7 minutes and 10 minutes) of dispersing time.

Fourth step: treating the third mixed solution at least once by adopting a high-pressure homogenizer at 40-120 MPa to obtain peony seed oil microemulsion; preferably, the number of treatments is generally 3 to 5 in order to ensure a uniform microemulsion.

Preferably, the sweet wormwood herb extract microemulsion is prepared from the following raw materials in percentage by mass:

For example: 5% of sweet wormwood herb extract, 0.001% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 40% of tridecyl alcohol polyether sodium sulfate, 3% of tridecyl alcohol polyether-3, 2% of sodium chloride and the balance of water;

alternatively, 20% of sweet wormwood extract, 0.1% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 10% of tridecyl alcohol polyether sodium sulfate, 0.1% of tridecyl alcohol polyether-3, 5% of sodium chloride and the balance of water;

Alternatively, 10% of sweet wormwood extract, 0.01% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 20% of tridecyl alcohol polyether sodium sulfate, 1% of tridecyl alcohol polyether-3, 4% of sodium chloride and the balance of water;

alternatively, 15% of sweet wormwood extract, 0.05% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 30% of tridecyl alcohol polyether sodium sulfate, 2% of tridecyl alcohol polyether-3, 3% of sodium chloride and the balance of water.

Further, in order to obtain stable sweet wormwood extract microemulsion, the preparation method of the sweet wormwood extract microemulsion comprises the following steps:

the first step: stirring herba Artemisiae Annuae extract and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at constant temperature in water bath of 75-85deg.C (for example: 75deg.C, 80deg.C or 85deg.C) for 10-20 min (for example 10min, 15min or 20 min), and continuing to ultrasonic under water bath condition until no granule transparent liquid is obtained to obtain fourth mixed solution.

And a second step of: stirring the trideceth sodium sulfate, the trideceth-3 and water in a water bath with a temperature of 75-85 ℃ (for example, 75 ℃, 80 ℃ or 85 ℃) for about 20-30 min (for example, 20min, 25min or 30 min) until no particles are uniform, and obtaining a fifth mixed solution.

And a third step of: and (3) uniformly mixing and stirring the fourth mixed solution and the fifth mixed solution at 55-65 ℃ (for example, 55 ℃, 60 ℃ or 65 ℃), then placing the mixture in an IKA T25 dispersing machine, and dispersing for 5-10 (for example, 5min, 7min and 10 min) minutes at the rotating speed of 8000-14000 rpm to obtain a sixth mixed solution.

Fourth step: treating the sixth mixed solution at least once by adopting a high-pressure homogenizer at 40-120 MPa to obtain sweet wormwood extract microemulsion; preferably, the number of treatments is generally 3 to 5 in order to ensure a uniform microemulsion.

The preparation method of the silicone oil-free anti-dandruff shampoo composition provided by the embodiment of the application is used for the silicone oil-free anti-dandruff shampoo composition provided by the embodiment of the application, and comprises the following steps: the components are mixed uniformly.

In some embodiments of the present application, the silicone oil-free anti-dandruff shampoo compositions may be prepared from the following raw materials:

5 parts of surfactant, 0.2 part of polymer thickener, 0.02 part of chelating agent, 0.2 part of pseudoalteromonas fermentation product, 10 parts of peony seed oil, 1 part of sweet wormwood extract, 0.1 part of conditioner, 0.01 part of pH regulator and 0.001 part of preservative;

or 50 parts of surfactant, 2 parts of polymer thickener, 0.03 part of chelating agent, 10 parts of pseudoalteromonas fermentation product, 1 part of peony seed oil, 10 parts of sweet wormwood extract, 0.5 part of conditioner, 1 part of pH regulator and 1 part of preservative;

or 20 parts of surfactant, 1 part of high molecular thickener, 0.03 part of chelating agent, 1 part of pseudoalteromonas fermentation product, 5 parts of peony seed oil, 5 parts of sweet wormwood extract, 0.2 part of conditioner, 0.02 part of pH regulator and 0.5 part of preservative.

The features and properties of the present invention are described in further detail below in connection with specific examples and comparative examples.

The following peony seed oil microemulsions used in the examples were prepared from the following raw materials:

10% of peony seed oil, 0.01% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 20% of tridecyl alcohol polyether sodium sulfate, 1% of tridecyl alcohol polyether-3, 4% of sodium chloride and the balance of water;

the following examples and comparative examples were prepared from the following raw materials of the sweet wormwood extract microemulsion:

10% of sweet wormwood herb extract, 0.01% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 20% of tridecyl alcohol polyether sodium sulfate, 1% of tridecyl alcohol polyether-3, 4% of sodium chloride and the balance of water.

The pH of each of the following examples and comparative examples was in the range of 5.5 to 6.0.

Examples

Comparative example

Examples and comparative examples design description: each comparative example was compared with example 3, and each comparative example was 12% as the total amount of the components of the silicone oil-free anti-dandruff shampoo composition referred to in the components of example 3; except that the silicone oil-free anti-dandruff shampoo compositions referred to in the respective comparative examples comprise only 1 or 2 components, the missing one being replaced by the other 1 or 2 components.

Experimental example 1

The extent of improvement in dandruff density in the subjects was assessed: half-head experiment

Volunteer test

Subject requirements:

inclusion criteria: an adhesive dandruff ten-level scoring method is adopted, namely, a level 0 indicates no dandruff; the level 1 to 2 is small powder gray rough scales; the 3-4 grades are small to medium sized chips; the 5-6 grades are large and thin chips loosely connected with the scalp; the grade 7 to 8 is large adhesive chips; the scale 9-10 is a thick scale of white to yellow, which adheres closely to the scalp. A total of 6 regions of the scalp (three regions of the left and right sides were taken respectively) were scored by ten-level scoring and added, and subjects with a dandruff score of 25 or more before the test were included in the test study.

Exclusion criteria:

(1) Scalp skin diseases such as eczema, psoriasis, tinea capitis, asbestos-like pityriasis or obvious seborrheic dermatitis;

(2) A clinical trial or other trial with the drug added over 30 days;

(3) For 1 month, there are cases of antifungal drugs or glucocorticoids for external use or oral administration;

exit criteria: study protocol violations during the trial period were due to pregnancy, adverse reactions, etc.

A total of 220 dandruff subjects were used, 110 men and 110 women, and the subjects were aged between 20 and 50 years. The two groups are divided into 11 groups, and 10 men and 10 women are respectively arranged in each group.

The method comprises the following steps: half-head experiments. The subjects split their hair into 2 sides, while using the experimental samples of examples and comparative examples, the other side maintained their original shampoo. Test 28D was tested according to the habitual shampoo frequency of the subjects and the test specimens were evaluated according to their own experiences. (5 min: very good, substantially free of dandruff; 4 min: very good, free of fine scales, 3 min: good, direct view of fine scales; 2 min: generally, relatively less than the other side, 1 min: no difference, about 2 min of dandruff density equivalent, 0 min: difference, more than the other side of dandruff). The average of the 20 sets of score scores was calculated by summing them and the average results were recorded in table 1.

Table 1 average score for each experimental group

Group of

Example 1

Example 2

Example 3

Example 4

Example 5

/

Average score

4.1

5

4.4

4.05

/

Group of

Comparative example 1

Comparative example 2

Comparative example 3

Comparative example 4

Comparative example 5

Comparative example 6

Average score

3.8

3.45

3.8

3

2.8

2.7

From the experimental results, it can be seen that the volunteers had significantly reduced dandruff density after shampooing using the shampoo compositions provided in examples of the present application, and comparing examples 1-5 with each of the comparative examples, it can be seen that the volunteers shampooed using examples 1-6 had significantly better dandruff improvement than the volunteers shampooed using comparative examples 1-6, especially with examples 2 and 3. However, the total amount of the components of the silicone oil-free anti-dandruff shampoo composition in example 3 is the same as that of the silicone oil-free anti-dandruff shampoo compositions in comparative examples 1-6, but the effect of the silicone oil-free anti-dandruff shampoo composition in comparative examples 1-6 is poorer than that of the silicone oil-free anti-dandruff shampoo composition in example 3, so that the fermentation product of pseudoalteromonas, the peony seed oil and the sweet wormwood herb extract are matched in a proper proportion to have a better anti-dandruff effect, and a synergistic effect can be generated. In the embodiment 2, the addition amount of the peony seed oil and the sweet wormwood oil microemulsion is larger, the use feeling experience is slightly poor, and in the hair bundle cleaning and blow-drying process, the phenomenon that hair is sticky, hair bundles are greasy and not refreshing enough exists after the microemulsion is broken after kneading is adopted, and the cost is 2 times that of the embodiment 3, so that the cost performance is not high, the most preferred embodiment is the embodiment 3, and in general practical production, the cost and the effect can be both achieved when the formula is close to that of the embodiment 3.

Experimental example 2

In vitro test method

And (3) a shampoo bacteriostasis ring experiment is carried out to judge the anti-dandruff effect.

Reference is made to QB/T2738 2012, methods for evaluating the antibacterial and bacteriostatic effects of daily chemical products, cosmetic safety specifications, and disinfection specifications.

1. Preparation of test pieces

A small amount of shampoo was sucked up with a sterile pipette and spread evenly on a sterile and dry 5mm filter paper sheet, and a negative control sample was prepared with sterile distilled water in the same manner, and left to dry naturally at room temperature for further use.

2. Inoculation of test bacteria

Dipping concentration of 5X 10 with sterile cotton swab ⁵ ～5×10 ⁶ c CFU/mL test bacterial suspension is uniformly smeared on the surfaces of Leeming and Notman culture medium plates. The plate was covered and left to dry at room temperature for 5min.

3. Bacteriostatic agent sample wafer sticking device

1 bacteria-staining plate is attached to each test, and 4 test pieces, 1 negative control piece and 5 pieces are attached to each plate. The sample piece was attached to the surface of the plate using sterile forceps. After the sticking, the sample wafer is lightly pressed by sterile forceps to be tightly attached to the surface of the flat plate. The plate is covered, placed in a 32 ℃ incubator and cultured for 7-10 days for observation. The diameter of the inhibition ring (including the patch) was measured with a vernier caliper and recorded.

This experiment adds 2 blank cases on an example basis, blank case a versus example 3: no anti-dandruff composition is contained, and the anti-dandruff composition is replaced by the same amount of deionized water; blank B versus example 3: no anti-dandruff composition, no preservative, and equivalent deionized water. The results of the inhibition ring experiments were carried out for examples 1 to 5, comparative examples 1 to 6 and two blank examples, respectively, and are shown in Table 2.

Table 2 results of the inhibition zone experiments

From the experimental results, it can be seen that pityrosporum can be significantly inhibited by using the shampoo compositions provided in the examples of the present application. Comparing examples 1-5 with the respective comparative examples, it can be seen that the shampoo compositions of examples 2 and 3 showed more significant inhibition of pityrosporum than the shampoo compositions of comparative examples 1-6, and that the conventional preservative was not effective in inhibiting malassezia growth, but showed significant effect after the anti-dandruff composition was added. Therefore, the pseudomonas fermentation product, the peony seed oil and the sweet wormwood extract are matched in a proper proportion, so that the effect of inhibiting the pityrosporum is better, the synergistic effect can be generated, and the obtained effect is particularly remarkable in the embodiment 3.

Experimental example 3

Anti-dandruff efficacy test at different concentrations:

1. experimental materials:

1.1 strain: BNCC 337308 Pityrosporum ovale (Pityrosporum ovale)

1.2 culture conditions: 30 DEG C

1.3 reagents and controls: negative Control (NC): the test sample is not added with bacterial liquid;

positive Control (PC): sterile distilled water with addition of bacteria solution;

test sample (TA): samples of the shampoo compositions of examples 1-5 and comparative examples 1-6 were diluted to 10% (v/v), 5% (v/v), 2.5% (v/v), 1.25% (v/v), 0.625% (v/v) and respectively in the concentration groups to be tested according to the test: medium = 1:1 ratio to medium to final concentration;

Culture medium: leemming & Notman agar Modified (MLNA) medium.

2. The test steps are as follows:

2.1 resuscitating and passaging strains: inoculating and subculturing with an inoculating loop under aseptic condition, wherein the 3 rd generation strain is used as a working strain.

2.2 preparation of bacterial liquid: diluting the stock solution with sterile physiological saline to obtain working solution with concentration of 1.6X10 ⁶ CFU/mL。

2.3 preparation of Medium plates:

2.3.1 preparation of sample-containing Medium plates: 10mL of diluted sample solution and 10mL of double-concentration MLNA agar medium are measured and added into a plate, so that the diluted sample solution and the medium are fully and uniformly mixed, and the diluted sample solution and the medium are solidified for standby.

2.3.2 preparation of positive control medium plates: 10mL of sterile distilled water and 10mL of double-concentration MLNA agar medium are measured and added into a plate, so that the sterile distilled water and the medium are fully and uniformly mixed, and the mixture is solidified for later use.

2.3.3 preparation of negative control Medium plates: 10mL of diluted sample solution and 10mL of double-concentration MLNA agar medium are measured and added into a plate, so that the diluted sample solution and the medium are fully and uniformly mixed, and the diluted sample solution and the medium are solidified for standby.

2.4 dibbling working bacteria liquid: and (3) taking 10 mu L of working bacteria liquid by a liquid transfer device, and dibbling the working bacteria liquid at the center of a sample-containing culture medium plate and a positive control culture medium plate, wherein the diameter of a bacterial liquid ring formed after inoculation is about 5-8 mm.

2.5 plates after inoculation were placed in an incubator at 30℃and incubated upside down, and 10 time points were observed and recorded for colony growth in each plate, respectively at 18h,24h,42h,48h,66h,72h,90h,96h,114h and 120 h.

The experimental results are recorded in tables 3-13.

TABLE 3 example 1 bacterial culture experiment results

TABLE 4 example 2 bacterial culture experiment results

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TABLE 5 example 3 bacterial culture experiment results

TABLE 6 example 4 bacterial culture experiment results

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TABLE 7 example 5 bacterial culture experiment results

TABLE 8 comparative example 1 bacterial culture experiment results

TABLE 9 comparative example 2 bacterial culture experiment results

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TABLE 10 comparative example 3 bacterial culture experiment results

TABLE 11 comparative example 4 bacterial culture experiment results

Table 12 comparative example 5 results of bacterial culture experiments

TABLE 13 comparative example 6 bacterial culture experiment results

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Note that: "+" indicates colony growth, and "-" indicates no colony growth

From experimental results, the shampoo composition provided by each embodiment of the application has excellent and long-acting antibacterial and anti-dandruff effects on malassezia furfur. Comparing examples 2 and 3 with each of the comparative examples, the example 1 plate at a concentration of 0.625% (v/v) developed colonies after 90 hours of cultivation, the example 4 plate at a concentration of 0.3125% (v/v) developed colonies after 48 hours of cultivation, the example 5 plate at a concentration of 0.625% (v/v) developed colonies after 120 hours of cultivation, and the comparative examples 1-6 developed colonies at a concentration of 1.25 or 2.5% (v/v), and the positive control plate developed colonies after 18 hours of cultivation; it can be seen that the shampoo plates of examples 2 and 3 still have no colony growth at the end of 120 hours observation, so that the fermentation product of pseudoalteromonas, the peony seed oil and the sweet wormwood extract are matched in a proper proportion to have better long-acting anti-dandruff effect, and a synergistic effect can be generated, in particular, example 3 achieves the same effect as example 2 on the premise that the total content of the anti-dandruff composition is less than that of example 2, and therefore, from the aspect of production cost, example 3 is more suitable for enterprise production, and therefore, in actual production, the same or similar formula as that of example 3 can be considered to be selected for production.

In summary, the silicone oil-free anti-dandruff shampoo composition provided by the application has the advantages that the defect of the traditional anti-dandruff agent is avoided by using the pseudoalteromonas fermentation product extract, the natural peony seed oil and the sweet wormwood extract are used as natural substitutes of the silicone oil, the silicone oil-free anti-dandruff shampoo composition is environment-friendly, the accumulation of the silicone oil on hair is avoided, the effects of antioxidation, antibiosis and anti-inflammatory are brought, the health of the whole scalp is maintained, and the dandruff condition of a user is obviously improved in a 28-day period of testing.

The present invention is not limited to the above embodiments, and any changes or substitutions that can be easily understood by those skilled in the art within the technical scope of the present invention are intended to be included in the scope of the present invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.

Claims

1. The silicone oil-free anti-dandruff shampoo composition is characterized by comprising the following components in parts by weight: 8-40 parts of surfactant and 5.2-25 parts of efficacy component;

5.2-25 parts of efficacy components comprise 0.2-5 parts of a pseudomonas fermentation product, 1-10 parts of peony seed oil microemulsion and 1-10 parts of sweet wormwood extract microemulsion, wherein the content of the peony seed oil in the peony seed oil microemulsion is 5-20wt%, and the content of the sweet wormwood extract in the sweet wormwood extract microemulsion is 5-20wt%;

The preparation raw materials of the peony seed oil microemulsion comprise the following components in percentage by mass: 5-20% of peony seed oil, 0.001-0.1% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 10-40% of tridecyl alcohol polyether sodium sulfate, 0.1-3% of tridecyl alcohol polyether-3, 2-5% of sodium chloride and the balance of water;

the preparation raw materials of the sweet wormwood herb extract microemulsion comprise the following components in percentage by mass: 5-20% of sweet wormwood herb extract, 0.001-0.1% of stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate, 10-40% of tridecyl alcohol polyether sodium sulfate, 0.1-3% of tridecyl alcohol polyether-3, 2-5% of sodium chloride and the balance of water.

2. The silicone oil-free anti-dandruff shampoo composition according to claim 1, wherein the components of the silicone oil-free anti-dandruff shampoo composition comprise, in parts by weight: 10-20 parts of surfactant and 7-21 parts of efficacy component; 7-21 parts of the efficacy components comprise 2-10 parts of peony seed oil microemulsion, 2-10 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

3. The silicone oil-free anti-dandruff shampoo composition according to claim 1, wherein the components of the silicone oil-free anti-dandruff shampoo composition comprise, in parts by weight: 10-20 parts of surfactant and 10-12 parts of efficacy component; the 10-12 parts of the efficacy components comprise 3-5 parts of peony seed oil microemulsion, 3-5 parts of sweet wormwood extract microemulsion and 1-3 parts of pseudoalteromonas fermentation product.

4. The silicone oil-free anti-dandruff shampoo composition according to claim 1, further comprising, in parts by weight: 0.2-2 parts of a thickener.

5. The silicone oil-free anti-dandruff shampoo composition according to claim 4, wherein said thickener comprises at least one of hydroxyethyl cellulose, carbomer, hydroxypropyl methylcellulose, hydroxypropyl cellulose and microcrystalline cellulose, PEG-150 distearate.

6. The silicone oil-free anti-dandruff shampoo composition according to claim 1, further comprising 0.1-0.5 parts by weight of a conditioning agent.

7. The silicone oil-free anti-dandruff shampoo composition according to claim 6, wherein said conditioning agent comprises at least one of cationic guar gum, coco trimethyl ammonium chloride, dihydroxypropyl PEG-5 lino ammonium chloride, polyquaternium-10, quaternary ammonium salt-82, polyquaternium-67, dioleoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, trimethylolpropane trioctanoate/triodecanoate, hydrolyzed silk, and hydrolyzed wheat protein.

8. The silicone oil-free anti-dandruff shampoo composition according to claim 1, further comprising 0.001-1 part by weight of a pH adjuster.

9. The silicone oil-free anti-dandruff shampoo composition according to claim 8, wherein said pH adjuster comprises at least one of citric acid, sodium citrate, sodium lactate, sodium hydroxide, arginine, potassium hydroxide, and lactic acid.

10. The silicone oil-free anti-dandruff shampoo composition according to claim 1, further comprising 0.001-1 part by weight of a preservative.

11. The silicone oil-free anti-dandruff shampoo composition according to claim 10, wherein said preservative comprises at least one of benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, sodium salicylate, methyl chloroisothiazolinone, methyl isothiazolinone, sodium benzoate, potassium sorbate, and DMDM hydantoin.

12. The silicone oil-free anti-dandruff shampoo composition according to claim 1, further comprising 0.02-0.3 parts by weight of a chelating agent.

13. The silicone oil-free anti-dandruff shampoo composition according to claim 12, wherein the chelating agent comprises at least one of EDTA-2Na, EDTA-4Na, tetrasodium glutamate diacetate, octanoyl hydroxamic acid, and p-hydroxyacetophenone.

14. The silicone oil-free anti-dandruff shampoo composition according to claim 1, wherein said surfactant comprises at least one of sodium lauroyl sarcosinate, disodium lauroyl amphodiacetate, propylene glycol laurate, cocamide MEA, sodium myristoyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glycinate, sodium laureth sulfate, sodium cocoyl aminopropionate, sodium lauroyl amphoacetate, cocamidopropyl betaine, disodium laureth sulfosuccinate, sodium cocoyl amphoacetate, trideceth-3, sodium trideceth sulfate, sodium lauryl hydroxysulfobetaine, sodium methyl cocoyl taurate, sodium laureth carboxylate, and sodium cocoyl-glucoside tartrate.

15. The silicone oil-free anti-dandruff shampoo composition according to claim 1, wherein the preparation method of the peony seed oil microemulsion comprises:

stirring peony seed oil and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at a constant temperature in a water bath at 75-85 ℃ for 10-20 min, and then continuing to ultrasonically treat the mixture until no-particle transparent liquid is obtained under the water bath condition to obtain a first mixed liquid;

stirring trideceth sodium sulfate, trideceth-3, sodium chloride and water at a constant temperature in a water bath at 75-85 ℃ until no uniform liquid is produced, and obtaining a second mixed liquid;

at 55-65 ℃, mixing and stirring the first mixed solution and the second mixed solution uniformly, and then placing the mixture into a dispersing machine for homogenizing and dispersing uniformly to obtain a third mixed solution;

16. The silicone oil-free anti-dandruff shampoo composition according to claim 15, wherein the second mixture is obtained by stirring at constant temperature for 20-30 minutes.

17. The silicone oil-free anti-dandruff shampoo composition according to claim 15, wherein the disperser homogenizing conditions are: the rotation speed of the IKA T25 dispersing machine is 8000-14000 rpm, and the dispersing time is 5-10 minutes.

18. The silicone oil-free anti-dandruff shampoo composition according to claim 15, wherein the number of treatments with a high pressure homogenizer is 3-5.

19. The silicone oil-free anti-dandruff shampoo composition according to claim 1, wherein the process for preparing the sweet wormwood extract microemulsion comprises:

stirring the sweet wormwood extract and stearyl alcohol di-tert-butyl-4-hydroxy hydrocinnamate at a constant temperature in a water bath at 75-85 ℃ for 10-20 min, and then continuing to carry out ultrasonic treatment under the water bath condition until no particle transparent liquid is obtained to obtain a fourth mixed liquid;

stirring trideceth sodium sulfate, trideceth-3, sodium chloride and water at a constant temperature in a water bath at 75-85 ℃ until no uniform liquid is produced, and obtaining a fifth mixed liquid;

and (3) treating the sixth mixed solution at least once by adopting a high-pressure homogenizer under 40-120 MPa to obtain the sweet wormwood extract microemulsion.

20. The silicone oil-free anti-dandruff shampoo composition according to claim 19, wherein the fifth mixture is obtained by stirring at constant temperature for 20-30 minutes.

21. The silicone oil-free anti-dandruff shampoo composition according to claim 19, wherein the disperser homogenizing conditions are: the rotation speed of the IKA T25 dispersing machine is 8000-14000 rpm, and the dispersing time is 5-10 minutes.

22. The silicone oil-free anti-dandruff shampoo composition according to claim 21, wherein the number of treatments with the high pressure homogenizer is 3 to 5.

23. A method of preparing a silicone oil-free anti-dandruff shampoo composition, comprising: the components are mixed uniformly.