CN114366693B - Shampoo bath lotion for infants - Google Patents

Abstract

The invention relates to the field of daily chemicals, and provides infant shampoo bath lotion which contains 12.5-35.5 wt% of surface active composition; the surface active composition comprises the following components in percentage by mass of 5-13: 4-10: 2 to 6:1 to 4:0.5 to 2.5 of lauroyl amphoacetate, cocamidopropyl betaine, sodium trideceth sulfate, sodium cocoyl methyl taurate and cocoyl glutamic acid TEA salt. The shampoo has the characteristics of mild, fine and rich foam and excellent elution property, and is suitable for infants.

Description

Shampoo bath lotion for infants

Technical field:

the invention relates to the field of daily chemicals, in particular to shampoo and bath cream for infants.

The background technology is as follows:

with the opening of the national three-child policy, the population number of infants will tend to rise, and the infant products on the market are in opportunity and also bring challenges. The national attention to the cosmetics for children is paid more and more, and the national drug administration formally publishes the exclusive mark of the cosmetics for children, namely 'Xiaojindun', which is beneficial to promoting the standardized development of the cosmetics market for children. However, the infant products on the market still pay much attention to market propaganda, and the design concept of the infant products is ignored. The skin is sticky and greasy after washing, the foam is not abundant, the jelly is formed at a low temperature, for example, the surfactant is cleaned by only amino acid surfactant, the insufficient cleaning force is easily caused by the too small dosage, the false slip phenomenon is reflected by excessive washing, the product is energized, active ingredients such as oat, chamomile and the like or Chinese herbal medicine ingredients are added to regulate the skin feel or impart certain functions, but the skin is possibly provided with risk substances such as methylisothiazolinone with cytotoxicity, DMDM hydantoin which can release formaldehyde, and the like. But the irritation of the product is easy to rise, so that the skin barrier of the infants which is not developed and mature is subjected to stress reaction.

Skin of young children has high water content, but the horny layer is thinner, and the percutaneous water loss rate is high; the skin is tender, and the hair is not too much soft; sweat gland density is higher than that of adults, functions are weaker, sweat temperature is slightly higher than that of adults, and total amount of lipid secreted by sebaceous glands is less; the skin barrier is weak and is sensitive to external stimuli. Therefore, the infant washing and protecting product needs to strictly screen raw materials, reduce impurity introduction, reduce the variety and the dosage of the raw materials as much as possible on the basis of meeting the core performance (cleaning and foam), and carefully use essence, preservative, even coloring agent and other raw materials which are easy to cause adverse reactions on the weak skin of infants.

Therefore, the preferred further choice of surfactants for existing shampoo or bath products is nonionic or amphoteric surfactant to reduce skin irritation.

The shampoo and bath lotion comprises a zwitterionic surfactant, sodium lauroyl sarcosinate, decyl glucoside, an acrylic ester copolymer, PEG-80 sorbitan laurate, glycerol oleate, dipotassium glycyrrhizinate, camellia seed oil, aloe extract, oat extract, PEG-40 hydrogenated castor oil, triethanolamine, benzyl alcohol, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate, essence, EDTA disodium and deionized water.

It discloses the use of amphoteric surfactants, amino acid surfactants to reduce skin irritation

CN202010188567.1 discloses a silicon-free compliant anti-dandruff shampoo, which is prepared from the following raw materials: dodecyl alcohol ether ammonium sulfate, sodium cocoyl glycinate, cocamidopropyl betaine, glycerol, jojoba oil, decyl glucoside, beadlets, antidandruff agents, nonionic surfactants, cocamide MEA, chamomile extract, guar hydroxypropyl trimethylammonium chloride, p-hydroxyacetophenone, hexylene glycol, polyquaternium-10, polyquaternium-7, panthenol, wheat gluten extract, sesame seed extract, chelating agents, deionized water. The shampoo with excellent softening effect is prepared by taking dodecyl alcohol ether ammonium sulfate as a main surfactant and sodium cocoyl glycinate as an auxiliary surfactant in a formula, then matching with cocamidopropyl betaine, glycerol, jojoba oil and decyl glucoside and a plurality of conditioning agents, and then adding an antidandruff agent OCT, and combining with the cocamidopropyl betaine, thereby having good antidandruff effect.

It discloses the use of nonionic surfactant, anionic surfactant, amino acid surfactant and amphoteric surfactant to enhance the shampoo antidandruff effect.

Patent CN 109718146A discloses a shampoo and bath lotion for children, which is characterized in that components such as olive fruit extract, purslane extract, hydrolyzed wheat protein, peppermint and the like are adopted to endow sterilizing and mosquito-repellent functions, but also methyl isothiazolinone is adopted, so that the shampoo and bath lotion is easy to cause irritation to tender skin of the young children.

Patent CN 108904331A discloses a shampoo and bath lotion of infant camellia oil and a preparation method, although camellia oil is used for caring skin, sodium sulfate of month Gui Jumi and cocamide DEA are adopted, so that the shampoo and bath lotion is strong in cleaning power, easy to cause excessive cleaning, contains methylthiazolinone and methylisothiazolinone, and is easier to cause irritation to skin of an infant in a bathing process.

In the research process, the problem that the irritation of the shampoo for infants is reduced is closely related to the mildness and elution of the raw materials, and meanwhile, the skin damage caused by excessive cleaning can be avoided due to the good foam performance is discovered.

Therefore, the technical problems to be solved in the scheme are as follows: how to realize the comprehensive improvement of the foam performance, the elution performance and the mildness of the infant shampoo.

The invention comprises the following steps:

in order to solve the problems, the invention provides the shampoo and the bath lotion for infants, which have the characteristics of mildness, fine and rich foam and excellent elution property and are suitable for infants.

The invention is realized by the following technical scheme:

an infant shampoo bath lotion contains 12.5-35.5 wt% of a surfactant composition;

the surface active composition comprises the following components in percentage by mass of 5-13: 4-10: 2 to 6:1 to 4:0.5 to 2.5 of lauroyl amphoacetate, cocamidopropyl betaine, sodium trideceth sulfate, sodium cocoyl methyl taurate and cocoyl glutamic acid TEA salt.

The amphoteric surfactant mainly comprises three types of imidazoline type, betaine type and lecithin, wherein the lecithin is often used as an emulsifier due to good emulsifying capacity, the imidazoline type comprises sodium lauroyl amphoacetate, disodium cocoyl amphodiacetate and the like, the betaine type comprises cocamidopropyl betaine, cocoyl betaine and the like, the amphoteric surfactant has mild performance, and the amphoteric surfactant can obviously reduce the irritation of the surfactant to skin by being compounded with other surfactants, particularly with anionic surfactants, has excellent foaming speed and rich foam, can regulate the viscosity of a system in a certain range, and can enhance the softness of hair and skin after washing.

The main types of amino acid surfactants are N-fatty acyl amino acids and salts thereof, and according to the types of carboxyl groups and amino groups, glutamic acid, glycine, sarcosine, methyl taurine and the like are common according to the types of amino groups and carboxyl groups respectively. The cocoyl glutamic acid TEA salt has good affinity and conditioning performance to skin, has better foam performance than other systems under weak acid condition, can increase foam elasticity, has excellent water solubility, and is suitable for weak acid and transparent systems; the cocoyl methyl taurine sodium salt has good compatibility with other surfactants, can obviously improve the system foam density, improves the water permeability, and can endow the washed skin with a comfortable feel and a soft hair feel.

The anionic surfactant is divided into sulfate, carboxylate, sulfonate and the like according to hydrophilic groups, wherein sodium dodecyl polyoxyethylene ether sulfate is common in washing and protecting products and is a main surfactant, and sodium tridecyl alcohol polyether sulfate can ensure the detergency of a system, has a lower CMC value compared with sodium dodecyl polyoxyethylene ether sulfate because of the existence of branched chains, is easier to form micelles, and reduces the irritation reaction of skin of infants caused by the residue of free monomers on the skin.

By comprehensive comparison, the scheme selects the combination of sodium lauroyl amphoacetate, cocamidopropyl betaine, sodium trideceth sulfate, sodium cocoyl methyl taurate and cocoyl glutamic acid TEA salt, and the several types of surfactants can obtain the optimized synergistic enhancement effect after the combination of the surfactants, which are mild, fine and rich in foam and excellent in elution.

The infant shampoo bath lotion further comprises 0.5-2wt% of a thickening agent, wherein the thickening agent is PEG-150 distearate.

PEG-150 distearate has obvious tackifying phenomenon and skin moisturizing effect when added in a small amount, is suitable for a surfactant system which is difficult to thicken, is not easy to generate a pseudoplastic rheological state and a low-temperature (4 ℃) jelly state, prevents long-time storage or weather temperature change from influencing use experience, does not need additional alkali liquor for neutralization thickening, and increases extra cost and operation steps.

The shampoo bath lotion for infants further comprises 4.95-13.5 wt% of humectant.

In the infant shampoo and bath lotion, the humectant is at least one of glycerol, 1, 3-butanediol, trehalose and PPG-10 methyl glucose ether.

The humectant adopts any of glycerin, 1, 3-butanediol, trehalose and PPG-10 methyl glucose ether. The skin has the advantages that secondary bound water exists in the stratum corneum of the skin, about 40% of the water is bound, but the skin is loose in binding with the stratum corneum, so that the skin is easy to lose and hydrate, the water absorption and the water binding capacity of the stratum corneum of the skin can be enhanced by adding polyalcohols such as glycerol and 1, 3-butanediol, and the polyalcohols have a synergistic effect on corrosion prevention; in addition, free water accounting for 40% of water exists on the skin, the loss speed is faster, but a film can be formed on the surface of the skin by adding a certain amount of saccharides such as trehalose, the skin has the function of radiating out external heat, the evaporation of the skin water can be prevented in a short time, the content of the free water in the stratum corneum is increased, the trehalose has the function of helping hair to keep a natural structure, and the trehalose has a good hair care effect by adding natural moisture; the PPG-10 methyl glucose ether can slow down the water loss of skin, improve the sticky feeling of the washed surface active agent, keep the soft and smooth feeling of the skin, and improve the softness of the hair after washing.

The shampoo and bath lotion for infants further comprises at least one of antiseptic auxiliary agent, natural aromatic, pH regulator, chelating agent and solubilizer.

In the infant shampoo and bath lotion, the anti-corrosion auxiliary agent is at least one of ethylhexyl glycerol, octyl glycol and p-anisic acid;

the natural aromatic is at least one of orange peel oil, bergamot fruit oil and magnolia flower oil;

the pH regulator is citric acid or sodium citrate;

the chelating agent is disodium ethylenediamine tetraacetate or disodium ethylenediamine tetraacetate;

the solubilizer is PEG-40 hydrogenated castor oil or PEG-80 sorbitan laurate.

Preferably, the raw materials with antiseptic effect are adopted, but the raw materials are not in the surface of a preservative for the quasi-cosmetics, such as ethylhexyl glycerol, and the raw materials are matched with polyalcohol, so that the raw materials have excellent growth inhibition effect on bacteria and fungi; the octanediol has the moisturizing effect on capturing water molecules by the hydrophilic group of the octanediol, has interference inhibition on the cell membrane of microorganisms, and can form vesicle or rupture to play an antibacterial role; for anisic acid, H can be ionized under weak acidity ⁺ Protons and weak acid radical ions can gradually cause weak acid negative in bacterial cellsAccumulation of ions, influence metabolism aggravate energy loss, etc.

Any one or more of the orange peel oil, bergamot fruit oil, magnolia flower oil and the like are preferably adopted, so that the skin is moistened, the skin has unique fragrance, pleasant fragrance in the use process is provided, clear and vivid smell is preferably considered, and the skin is gentle and soft;

preferably, any one of citric acid and sodium citrate is adopted to adjust the pH of the system;

preferably, any one of disodium ethylenediamine tetraacetate and disodium ethylenediamine tetraacetate is adopted to soften hard water;

preferably, any one of PEG-40 hydrogenated castor oil and PEG-80 sorbitan laurate is adopted to maintain the stability and uniformity of the system.

The dosage of the full formula of the invention is optimized as follows:

lauroyl amphoacetate sodium: 5 to 13 percent

Cocamidopropyl betaine: 4 to 10 percent of

Tridecyl alcohol polyether sodium sulfate: 2 to 6 percent of

Sodium cocoyl methyl taurate: 1 to 4 percent of

Cocoyl glutamic acid TEA salt: 0.5 to 2.5 percent

PEG-150 distearate: 0.5 to 2 percent

Glycerol: 4 to 10 percent of

Ethylhexyl glycerol: 0.1 to 0.5 percent

Octyl glycol: 0.1 to 0.5 percent

Trehalose: 0.5-1.5%

PPG-10 methyl glucose ether: 0.25-1%

Citric acid: 0.3-0.6%

P-anisic acid: 0.15-0.45%

PEG-40 hydrogenated castor oil: 0.15 to 0.3 percent

Orange peel oil: 0-0.1%

Magnolia oil: 0-0.05%

Disodium edetate: 0.05 to 0.12 percent

Deionized water: the content is 100%.

The pH range of the bath foam is as follows: 5.0-5.8.

The beneficial effects of the invention are as follows:

according to the invention, through setting up different surface active types and dosages and under the cooperation of components such as moisture preservation, conditioning and the like, excellent cleaning power and foaming power are ensured, the foam is well defoamed after water is added, the flushing performance is high, the obvious irritation of the surfactant to the skin is weakened, and the bathing agent is more friendly and convenient for soaking and bathing of infants of 0-3 years old. The formula has low cost, simple preparation method and simple operation, and is suitable for large-scale production.

Drawings

FIG. 1 is a schematic diagram of the chick embryo of example 2 before the experiment, wherein the chick embryo is in a normal state;

FIG. 2 is a schematic diagram of the experimental results of the chick embryo of example 2, wherein the chick embryo only shows slight hyperemia, and is slightly damaged;

FIG. 3 is a schematic diagram of the chick embryo of comparative example 11 before the experiment, and the chick embryo is in a normal state;

FIG. 4 is a schematic diagram of the experimental results of the chick embryo of comparative example 11, which clearly shows that the dissolution of blood vessels occurs in the polytetrafluoroethylene resin ring, and that about 1/4 of the blood vessels disappear, possibly as irreversible damage, is a more serious damaging stimulus.

The specific embodiment is as follows:

the embodiments described below are intended to be further illustrative of the invention and not limiting, and any variations based on the gist of the invention that would be understood by a person skilled in the art are within the scope of the invention.

The preparation process of all examples and comparative examples of the present invention is as follows:

(1) sequentially adding the phase A into an emulsifying pot, heating to 73-78 ℃, homogenizing and stirring to completely dissolve and transparent, and preserving heat and stirring for 15-20 minutes to remove foam;

(2) cooling the cooling water to 60 ℃, firstly putting the phase B into an emulsifying pot, homogenizing, stirring and dissolving completely, and then preserving heat and stirring for 15-20 minutes;

(3) then cooling water is started to cool to 40 ℃, phase C is added, and citric acid is used for adjusting pH.

Examples 1 to 3

The formulations of examples 1-3 can be referred to in Table 1 below

Table 1 formulation tables of examples 1-3

Examples 4 to 6

The formulations of examples 4-6 can be referred to in Table 2

Table 2 formulation tables of examples 4-6

Comparative examples 1 to 6

The formulation tables of comparative examples 1 to 6 can be referred to Table 3

Table 3 formulation of comparative examples 1-6

Comparative examples 7 to 10

The formulation tables of comparative examples 7 to 10 can be referred to Table 4

Table 4 Table of formulas of comparative examples 7 to 10

In comparative example 7 of the present invention, sodium lauroyl amphoacetate was replaced with disodium cocoyl amphodiacetate in equal amounts;

in comparative example 8 of the present invention, cocamidopropyl betaine was replaced with cocamidopropyl hydroxysulfobetaine in equal amounts;

in comparative example 9 of the present invention, cocoyl glutamic acid TEA salt was replaced with sodium lauroyl sarcosinate in equal amount;

in comparative example 10 of the present invention, the sodium trideceth sulfate was replaced with an equivalent amount of ammonium dodecyl alcohol ether sulfate.

Example 11

The formula of the commercially available two-in-one shampoo and bath lotion for cleaning and protecting certain baby comprises the following components:

sodium laureth sulfate, lauramidopropyl betaine, sodium chloride, glycerin, PEG-7 glycerin cocoate, essence, citric acid, sodium benzoate, allantoin, hydrolyzed milk protein, olive leaf extract, potassium sorbate, hydroxypropyl guar hydroxypropyl trimethylammonium chloride.

Performance testing

Mildness test

Eye irritation-test chick embryo chorioallantoic membrane test

The detection basis is as follows: cosmetic eye irritation chick embryo chorioallantoic membrane vascular test QJ/AZ 0010.701-2020

1. Experimental materials:

1.1 chick embryo: SPF grade Bai Laihang chicken (White Leghorn chicken), purchased from Xin Hua Sheng egg Co., ltd., produced license number: SCXK (Guangdong) 2018-0019.

1.2 culture conditions: the incubation temperature is 37.5+/-0.5 ℃ and the relative humidity is 50-60%.

1.3 reagents and controls: positive Control (PC): 15% acrylamide.

Negative Control (NC): 0.9% NaCl solution.

Test sample (TA): 0.3g of the sample was weighed, and purified water was added to 30g to prepare a concentration of 3% (w/w).

The test steps are as follows:

2.1 test group

Each sample should be tested by using 10 chick embryos, each batch should be provided with negative control and positive control, each not less than 3 chick embryos, and if necessary, should be provided with solvent control.

2.2CAM preparation

Taking care of the air chamber with an egg candler, determining the position of the air chamber, manually drilling a small window on the air chamber by hand twisting, peeling off eggshell part on the upper layer of the air chamber with medical ophthalmic curved-tip forceps, exposing white eggshell membrane, dripping a proper amount of 0.9% sodium chloride solution into a suction pipe to moisten the eggshell membrane, and pouring out the 0.9% sodium chloride solution after the eggshell membrane is completely moistened. Carefully remove the eggshell membrane by forceps, carefully remove the eggshell membrane, ensure that the vascular membrane is not damaged, and expose abundant capillaries after removing the eggshell membrane, namely CAM.

2.3 test procedure

Stimulation scoring method: placing a polytetrafluoroethylene resin ring on a chorioallantoic membrane of a chick embryo to serve as a tested area, transferring 40 mu l of a sample to be tested into the polytetrafluoroethylene resin ring by using a liquid-transferring gun, recording the time of adding the sample, covering the air chamber by using a wetted preservative film, transferring the chick embryo into a constant temperature and humidity box for culturing for 30min, taking out the tested chick embryo, directly photographing, observing the vascular injury degree, and grading according to the vascular injury degree.

TABLE 5 scoring criteria table

2.4 analysis of results

The result of each egg should be evaluated and scored, and finally ten scores obtained are removed from the highest score and the lowest score, and 8 effective scores remain, and the stimulation score (NC) is calculated according to application formula (1).

NC＝(X ₁ +X ₂ +……+X _n )/n……………………(1)

Wherein:

x-stimulus score

n-number of effective chick embryos after removal of the highest score and the lowest score

The test subjects were classified according to table 2 for irritation based on the calculated NC values.

Table 6 irritation evaluation table

Conclusion 3

TABLE 7 results of mildness test

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The results illustrate:

(1) examples 1,2 and 3 were compared with each other using the same materials but with different amounts of surfactant, and as a result, there was a difference in scores, and there was a risk of increased irritation when the amount of surfactant was increased in examples 1 and 3. And compared with the embodiment 1 and the embodiment 2, the system irritation can be reduced by reasonably proportioning the dosage of the formula surfactant.

(2) Comparative examples 1,2,3,4,5 were compared with each other, and only one type of surfactant was removed, the other was unchanged, and the scores were different, indicating that the selection of the surfactant type had an effect on the system irritation, but the scores were higher than those of example 2, indicating that the dosage ratio of the surfactant had a greater effect on the system irritation.

(3) Example 2 compared to comparative example 6 demonstrates that the irritation of the system is reduced by the addition of PPG-10 methyl glucose ether;

(4) example 2 compared to example 11 demonstrates that the mildness through example 2 is significantly better than the commercially available product.

(5) Example 2 is compared with examples 4,5 and 6, and shows that the mildness of the formula system is determined by the influence of various components, but the mildness is greatly influenced by the collocation system of the surfactant;

(6) example 2 demonstrates the better compatibility of the surfactant system of example 2 by replacing the same types of surfactants one by one in equal amounts, but with a higher irritation score than example 2, as compared to comparative examples 7,8,9, and 10.

II, formula microorganism detection

Detection basis and method

Example 2 was examined by means of the cosmetic safety Specification (2015 edition)

TABLE 8 detection results

Conclusion: the microbiological test experiments of example 2 passed.

Third foam test

Detection basis and method

Shampoo and shampoo cream GB/T29679-2013

Table 9 test results

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Description of results

(1) Examples 1,2,3 are compared with each other, demonstrating that the amount of surfactant used has a great effect on the amount of foam in the system;

(2) comparative examples 1,2,3,4,5 illustrate that the most impact on foam height was found to be amphoteric surfactants and the least impact was found to be amino acid surfactants compared to example 2;

(3) example 2 is slightly lower than example 11, but far exceeds 40mm of national standard, which is enough to meet the bath requirements of infants and children, and too high foam height affects the washing clean speed after bath, etc.

(4) Examples 1,2,3,4,5,6 are compared with each other, which shows that the reasonable collocation of the surfactant affects the foam amount to the greatest extent;

(5) comparative examples 7,8,9,10 show that foam performance is still affected by the equivalent replacement of the same type of surfactant for the formulation, as compared to example 2.

Fourth, crowd trial test

1. Test protocol

The feedback was sent to 30 baby trials, with 60% of the baby's 0-3 years old and 40% of the baby's 3-12 years old, and the products tested were example 2 and a commercial baby cleansing and conditioning two-in-one shampoo. The same type of pump head packing material is used for blind measurement for 5 days, once a day, the evaluation mode adopts scoring 5 minutes, the 5 minutes are the best in effect, and the 1 minute is the worst in effect. The dimensions were evaluated for foaming speed, foam density, ease of rinsing, cleaning strength, after-use moisture retention, after-use skin softness and after-use hair softness.

Table 10 test results

The results illustrate:

overall, example 2 was the most excellent overall evaluation, with rapid overall foaming, dense and durable foam, good cleaning power, good water defoaming, easy rinsing, soft and tight skin after bathing, and soft and easy combing hair.

FIG. 1 is a schematic diagram of a chick embryo of example 2 before experiment, wherein the chick embryo is in a normal state; FIG. 2 is a schematic diagram of the experimental results of the chick embryo of example 2, wherein the chick embryo only shows slight hyperemia, and is slightly damaged; FIG. 3 is a schematic diagram of the chick embryo of comparative example 11 before the experiment, and the chick embryo is in a normal state; FIG. 4 is a schematic diagram of the experimental results of the chick embryo of comparative example 11, which clearly shows that the dissolution of blood vessels occurs in the polytetrafluoroethylene resin ring, and that about 1/4 of the blood vessels disappear, possibly as irreversible damage, is a more serious damaging stimulus.

From fig. 1-4 we can conclude that: example 2 is significantly less irritating than comparative example 11, is significantly less gentle, and is a better choice for baby Tong Rouruo skin washing.

Claims (5)

1. A shampoo bath lotion for infants is characterized by comprising 23.5wt% of a surfactant composition, 7wt% of glycerol, 1wt% of trehalose and 0.6wt% of PPG-10 methyl glucose ether;

the surface active composition comprises the following components in percentage by mass: 7:4:2:1.5 sodium lauroyl amphoacetate, cocamidopropyl betaine, sodium trideceth sulfate, sodium cocoyl methyl taurate, and TEA cocoyl glutamate.

2. The infant shampoo shower gel according to claim 1, further comprising 0.5 to 2wt% of a thickener which is PEG-150 distearate.

3. The infant shampoo and bath lotion according to claim 1, further comprising at least one of a preservative aid, a natural fragrance, a pH adjuster, a chelating agent, and a solubilizing agent.

4. The infant shampoo bath foam according to claim 3, wherein the antiseptic aid is at least one of ethylhexyl glycerol, octyl glycol and p-anisic acid;

the natural aromatic is at least one of orange peel oil, bergamot fruit oil and magnolia flower oil;

the pH regulator is citric acid or sodium citrate;

the chelating agent is disodium ethylenediamine tetraacetate or disodium ethylenediamine tetraacetate;

the solubilizer is PEG-40 hydrogenated castor oil or PEG-80 sorbitan laurate.

5. The infant shampoo shower gel according to any one of claims 1 to 4, wherein the pH range of the shower gel is: 5.0-5.8.