CN112370393B - Hair washing mousse composition and preparation method and application thereof - Google Patents
Hair washing mousse composition and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The invention discloses a hair washing mousse composition and a preparation method and application thereof, and relates to the technical field of daily cosmetics. The hair washing mousse composition comprises a surfactant compound and active ingredient nanoliposomes; the surfactant formulation comprises cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl glutamate, TEA cocoyl alanine, and sodium methyl cocoyl taurate; the active ingredient nanoliposome comprises a hypecoum extract, fructan, a houttuynia cordata extract and a complex of sodium cocoyl amino acid/sarcosine/potassium aspartate/magnesium aspartate. The hair washing mousse prepared from the hair washing mousse composition has no stimulation to skin, can penetrate into hair follicles, and has a good repairing effect on the scalp.
Description
Technical Field
The invention relates to the technical field of daily cosmetics, in particular to a hair washing mousse composition and a preparation method and application thereof.
Background
The washing and caring products have gone through the stages of basic cleaning, nourishing, mildness, sterilization and the like, and the incidence rate of sensitive skin is higher globally along with the increasing environmental pollution, the increasing mental stress, the change of skin care habits and the like. Studies have shown that about 40-50% of europe report the phenomenon of skin sensitization. The scalp sensitivity ratio of Chinese women evaluated by oneself is 35.77%, and the scalp sensitivity ratio found by a 3S questionnaire is 57.45%. Sensitive Skin (SS) refers to a condition of high skin reaction under physiological or pathological conditions, and is clinically manifested as subjective symptoms such as burning, stabbing pain, itching and tightness of skin when being stimulated by physical, chemical and mental factors, and objective signs such as erythema, scaling and telangiectasia are occasionally accompanied. For sensitive scalp, itching is the most common symptom. Sensations of tightness, burning, stinging, etc. are similar to those of the sensitive skin of the face, which can be associated with the sensitive skin of the face, dandruff cannot be considered as a symptom of the sensitive skin, which is sometimes associated with certain scalp disorders: seborrheic dermatitis, dermatitis due to hair dyeing, rosacea, scalp psoriasis, atopic dermatitis, etc.
The mechanisms underlying sensitive scalp are primarily related to both increased stratum corneum permeability and sensory nerve hyperreactivity. Sensitive skin typically suffers from disruption of the stratum corneum. When the function of the scalp barrier is damaged, the water in the horny layer can flow out along the gaps of the damaged sebum membrane on the skin surface, and the water loss of the epidermis is increased, so that the skin can be dried after the water loss. Dry skin affects the process of keratinocyte maturation, during which some lipid components are changed and the keratinocytes shrink, at which time numerous gaps appear in the brick wall structure of the skin, thus aggravating the breakdown of the skin barrier. Thus, two changes occur to the sensitive scalp: 1) impaired skin barrier function: the skin's various barriers (primarily physical barriers) are compromised; thinning of the stratum corneum with a reduced number of keratinocytes results in increased transdermal absorption of water-soluble chemicals; the damaged skin barrier reduces protection of nerve endings while increasing transdermal water loss; 2) nervous system mediated discomfort: an increase in the density of epidermal nerve endings may occur after repeated inflammatory reactions in sensitive skin individuals, as has been demonstrated in skin lesions of atopic dermatitis patients. The expression of nociceptive receptors (such as transient receptor potential channel family-TRP) in nerve endings and keratinocytes of sensitive skin is up-regulated, which is likely to cause pain, itching and burning sensation in sensitive skin individuals.
At present, various types of shampoos aiming at sensitive scalp exist in the market, but all have the problems that the concentration of a common shampoo stock solution is higher, the shampoo stock solution can be cleaned only by rubbing to generate foam, and the sensitive scalp is easy to induce sensitive reaction after contacting with the high-concentration shampoo. On the other hand, some active ingredients are generally added into some shampoos designed for sensitive hair, but the active ingredients lack a proper delivery way, so that the active ingredients of the shampoos are quickly washed away in the using process, and are difficult to stay on the scalp to exert due effects, so that a mild and efficient shampoo is urgently needed, is mild and non-irritant, and can deliver moisturizing, repairing and relieving ingredients required by the sensitive hair to corresponding parts of the scalp to achieve due repairing effects.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the shampoo mousse composition with mild property and good repairing effect as well as the preparation method and the application thereof.
In order to realize the purpose, the technical scheme adopted by the invention is as follows: a hair washing mousse composition which is characterized by comprising a surfactant compound and active ingredient nanoliposomes; the surfactant formulation comprises cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl glutamate, cocoyl glutamate TEA salt, cocoyl alanine TEA salt, and sodium methyl cocoyl taurate; the active ingredient nanoliposome comprises anise extract, levan, houttuynia cordata extract, sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate.
The applicant of the present invention screened surfactants using a zein-azotometer detection method to reduce the irritation of surfactants on sensitive scalp.
The applicant of the invention proves through a large number of experiments that the surfactant prepared by compounding cocoamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl glutamate, TEA salt of cocoyl glutamic acid, TEA salt of cocoyl alanine and sodium methyl cocoyl taurate has good emulsification and foaming properties and low irritation.
Preferably, the surfactant formulation comprises the following ingredients in parts by weight: 10-20 parts of cocamidopropyl hydroxysultaine, 10-15 parts of a compound of sodium lauroyl sarcosinate and sodium lauroyl glutamate, 2-10 parts of cocoyl glutamic acid TEA salt, 2-10 parts of cocoyl alanine TEA salt and 1-5 parts of sodium methyl cocoyl taurate. The applicant of the invention proves through multiple experiments that the surfactant compounded according to the proportion has low irritation when being used for washing hair mousse and has good emulsification and foamability.
Preferably, the surfactant formulation comprises the following ingredients in parts by weight: 12-18 parts of cocamidopropyl hydroxysultaine, 11-14 parts of a compound of sodium lauroyl sarcosinate and sodium lauroyl glutamate, 4-8 parts of cocoyl glutamic acid TEA salt, 4-8 parts of cocoyl alanine TEA salt and 2-4 parts of sodium methyl cocoyl taurate.
Preferably, the surfactant formulation comprises the following ingredients in parts by weight: 15 parts of cocamidopropyl hydroxysultaine, 12 parts of a compound of sodium lauroyl sarcosinate and sodium lauroyl glutamate, 5 parts of cocoyl glutamic acid TEA salt, 5 parts of cocoyl alanine TEA salt and 3 parts of sodium methyl cocoyl taurate. The applicant of the invention proves through multiple experiments that the surfactant compounded according to the proportion has the optimal comprehensive performance when being used for washing hair mousse, the hair washing mousse is easy to foam, and the stimulation to scalp is minimum.
Preferably, the active ingredient nanoliposome comprises the following components in parts by weight: 0.2 to 0.8 portion of anise extract, 0.5 to 1.5 portions of fructan, 0.1 to 0.5 portion of houttuynia extract, and 0.5 to 1.5 portions of complex of sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate.
The Craib Anemonium acutum extract is a special oil-soluble extract derived from Craib Anemonium acutum of Salicornia, contains special glycolipid (such as SQDG), oleic acid, erucic acid and phytosterols, and has effects of promoting synthesis of ceramide and filaggrin, improving cell respiration, inhibiting lipid peroxidation and inflammatory reaction, restoring water balance, and brightening skin color, and has effects of keeping moisture, resisting aging, caring skin and resisting allergy.
The levan achieves the anti-inflammatory effect by preventing the release of inflammatory mediator interleukin-1 alpha, can promote the regrowth of cells, is a multi-effect humectant, has the characteristic of self-forming nano particles and endows the product with velvet hand feeling; has effects in rapidly repairing damaged skin barrier and keeping skin moisture.
The houttuynia cordata extract is a natural foam/cleaning synergist with antibacterial effect, and the main active ingredient is quercetin, so that the houttuynia cordata extract can be dissolved to remove color cosmetics, has strong foaming capacity and stable foam; has obvious antibacterial effect on propionibacterium acnes and streptococcus mutans; and simultaneously can inhibit the expression of MMP-1 in human gingival fibroblasts.
Sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate: the skin care product has soothing and anti-irritation active ingredients, can prevent various mediums generated when skin is irritated, further effectively helps the skin to resist various external irritations and weakens the uncomfortable feeling of the skin; the important nutritional ingredients such as oil, amino acid and mineral substances contained in the skin care product can rebuild damaged skin and keep the skin moist. Is especially suitable for products aiming at sensitive skin.
The Nanoliposome (NLP) is hydrophilic colloidal particles formed by lipid materials in a water phase, and can wrap lipophilic and hydrophilic bioactive substances, enhance the storage time of the active substances and delay the release of the active substances, thereby improving the bioactivity and the utilization rate. It has the advantages of targeting property, no toxicity, no immunogenicity, high bioavailability, convenient absorption, high stability, etc. and is widely used in medicine, cosmetics, food, gene engineering, etc. The invention uses nano liposome to encapsulate the aniseed extract, fructan, houttuynia cordata extract, sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate, which can enter the deep tissue of skin through the skin cuticle to release the active ingredients continuously, thus realizing the transdermal co-delivery of the active ingredients, penetrating into hair follicle, being retained in the hair follicle for a long time and being capable of sustained release and controlled release, and obviously improving the bioavailability.
The applicant of the invention proves that the nano liposome prepared by compounding the hypsizygus marmoreus extract, the fructan, the houttuynia cordata extract, the sodium cocoyl amino acid, the sarcosine, the potassium aspartate and the magnesium aspartate is used as an active ingredient, and the nano liposome has a good effect of repairing scalp when being used in a hair washing mousse.
Preferably, in the compound of sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate, the mass ratio of sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate is that of sodium cocoyl amino acid: sarcosine: potassium aspartate: magnesium aspartate is 2:2:1: 1. The applicant proves through multiple experiments that when the active ingredients compounded according to the proportion are used in the hair washing mousse, the hair loss phenomenon can be effectively inhibited, and new hair growth can be promoted.
Meanwhile, the invention also discloses a preparation method of the active ingredient nanoliposome, which comprises the following steps: adding the hypecoum extract into ethanol, stirring at 70-80 deg.C for 10-20min, adding glycerol, levan, herba Houttuyniae extract, sodium cocoyl amino acid, sarcosine, potassium aspartate, magnesium aspartate and water, rapidly mixing to obtain colostrum, and homogenizing under 70-90MPa in a high pressure homogenizer for 3 times to obtain the active ingredient nanoliposome.
In addition, the invention also discloses a hair washing mousse which comprises the hair washing mousse composition. When the shampoo mousse is used, the aerosol can, the valve and the nozzle are combined, the shampoo foam is released in the mousse form, the shampoo mousse is convenient and quick, the foam pumped out each time is smooth and dense like cream, the foam is directly smeared on hair, and the foam is released instantly, so that not only can a consumer use the shampoo mousse more conveniently, but also the step of rubbing the foam and foaming is saved, and the irritation of the shampoo can be reduced. The mousse shampoo has the advantages that the same cleaning effect can be achieved mainly because the foam pumped by the mousse shampoo can relatively and directly rub the original liquid of the shampoo on the hair, but the concentration of the foam pumped by the pump head, which is directly contacted with the original liquid of the shampoo, in unit area of the scalp is greatly reduced, the irritation to the scalp is objectively reduced, and the mousse shampoo is suitable for consumers with sensitive scalp.
Preferably, the shampoo mousse further comprises the following ingredients: polyquaternium-10, EDTA disodium, allantoin, citric acid, hydroxyethyl urea, dipotassium glycyrrhizinate, betaine, wheat hydrolyzed protein, PPG-3 octyl ether, phenoxyethanol, potassium sorbate and sodium benzoate.
Preferably, the shampoo mousse further comprises the following ingredients in parts by weight: 100.1-0.5 part of polyquaternium, 0.03-0.07 part of EDTA disodium, 0.1-0.5 part of allantoin, 0.1-0.15 part of citric acid, 1.5-2.5 parts of hydroxyethyl urea, 0.1-0.3 part of dipotassium glycyrrhizinate, 0.3-0.7 part of betaine, 0.1-0.3 part of wheat protein hydrolysate, 0.1-0.5 part of PPG-3 octyl ether, 0.5-1 part of phenoxyethanol, 0.1-0.5 part of potassium sorbate and 0.1-0.5 part of sodium benzoate.
Meanwhile, the invention also discloses a preparation method of the hair washing mousse, which comprises the following steps:
(1) adding deionized water into an emulsifying pot, heating to 60-80 ℃, uniformly dispersing polyquaternium-10 in cold water, and then adding the mixture into the emulsifying pot for homogenizing for 2-3 minutes to obtain a mixed solution A;
(2) adding a compound of EDTA disodium and a surfactant into the mixed solution A in sequence, homogenizing for 3-8 minutes, and stirring for 20-40 minutes to obtain a mixed solution B;
(3) dispersing allantoin with cold water in advance, adding into the mixed solution B, and adding PPG-3 octyl ether;
(4) cooling to below 45 deg.C, sequentially adding the rest materials, wherein dipotassium glycyrrhizinate and sodium benzoate need to be dispersed with cold water, adding, and stirring to obtain the shampoo mousse.
Compared with the prior art, the invention has the beneficial effects that: the invention determines a surfactant compound by adopting a zein-Kjeldahl method, can quickly emulsify and foam, and has small irritation; then active ingredients are screened to prepare the active ingredient nanoliposome, so that active substances in the nano composition can permeate into hair follicles, the utilization rate of the active ingredients is improved, and the hair washing mousse prepared from the surfactant compound and the active ingredient nanoliposome has a good effect of repairing scalp and can be used for sensitive skin.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to the following examples. (unless otherwise specified, the parts by weight in the examples and comparative examples represent the same mass.)
The irritability of the surfactant is determined by adopting a zein-Kjeldahl method:
reagents used for testing (assay pure): copper sulfate pentahydrate, potassium sulfate, sulfuric acid, boric acid, a methyl red indicator, a bromocresol green indicator, a methylene blue indicator, ethanol, hydrochloric acid, and Zein (Zein).
Preparing a reagent:
1) preparation of boric acid + mixed indicator: firstly weighing 20g of boric acid, adding water to dissolve the boric acid, and diluting the boric acid to 1000mL to obtain a boric acid solution; then weighing 0.2g of methyl red, dissolving the methyl red into an ethanol solution with the volume fraction of 95 percent of ethanol, and metering the volume of the ethanol solution to 100mL to obtain an indicator A; then 0.2g of bromocresol green is weighed and dissolved in ethanol solution with the ethanol volume fraction of 95 percent, and the ethanol solution is diluted to 100mL to obtain the indicator B. And (3) uniformly mixing 10mL of the indicator A and 30mL of the indicator B, containing the mixture in a brown reagent bottle, and storing the mixture in a shade place. Pouring 1000mL of boric acid solution into a boric acid bucket, adding 3mL of mixed indicator, and fully and uniformly stirring for later use.
2) Preparing a sodium hydroxide solution with the NaOH mass fraction of 40 percent: 40g of sodium hydroxide was weighed, dissolved in water, and then diluted with water to 100 mL.
3) Preparation of hydrochloric acid standard titration solution with HCl concentration of 0.1000 mol/L: 9.0ml of hydrochloric acid is taken, water is added to the hydrochloric acid to fix the volume to 1000ml, the mixture is shaken up, and the concentration of the hydrochloric acid is calibrated by a sodium carbonate method.
Preparing a surfactant to be detected into a solution with an active substance mass fraction of 1.0%, taking 30mL, adding 3-5 g of Zein under a stirring condition, stirring at 25 ℃ for 90min, observing every 10-15 min, and adding Zein according to the situation to ensure that the solution contains enough undissolved Zein. Then standing and filtering. And the mass fraction of nitrogen in the filtrate is A by a trace Kjeldahl method. The mass fraction B of nitrogen in the surfactant solution without Zein was determined in the same manner.
The Zein value is a-B. The larger the Zein value, the more Zein dissolved, the more irritating the surfactant system. The Zein value is expressed in terms of mass fraction of nitrogen contained in the solution, and the irritativeness of the surfactant can be classified into 3 types by the Zein value:
(1) the surfactant with the Zein value of more than 4g/L solution is strong in stimulation, and the surfactant has stronger solubilizing capability on Zein.
(2) The surfactant with the Zein value of 2-4 g/L of solution is low in irritation.
(3) Surfactants with Zein values less than 2g/L of solution are "non-irritating" and such surfactants have a weaker effect in promoting the dissolution of Zein.
Kjeldahl method: transferring 3mL of filtrate added with Zein into a digestion tube, adding 0.2g of blue copper sulfate pentahydrate, 2.5g of potassium sulfate and 10mL of sulfuric acid, placing the digestion tube in a digestion furnace for digestion for 110min to obtain a light blue clear transparent digestive juice, and synchronously using a solution without Zein as a blank control. The temperature program during digestion is shown in table 1.
TABLE 1 digestion temperature program
Standing and cooling the digested sample, adding 10mL of distilled water, shaking up, moving to a specified position of a full-automatic nitrogen determinator, pouring boric acid and a mixed indicator into the specified position of the full-automatic Kjeldahl nitrogen determinator, adjusting the full-automatic Kjeldahl nitrogen determinator to an automatic mode, setting relevant parameters, clicking to run, automatically completing the distillation and titration processes, and recording the amount of consumed hydrochloric acid standard titration solution.
The formula for calculating the nitrogen content is as follows:
n is the content of nitrogen in the sample, and the unit is g/L;
v is the volume of hydrochloric acid standard titration liquid consumed by adding Zein test solution, and the unit is mL;
v0-the volume of hydrochloric acid standard titration solution is consumed without adding Zein test solution, and the unit is mL;
c, the concentration of the hydrochloric acid standard titration solution is in mol/L;
0.014-1.0 mL of HCl with a concentration of 1mol/L of hydrochloric acid standard titration solution equivalent to the mass of nitrogen in g;
v sample-mass of sample in mL.
The Zein values N measured for the different surfactants are shown in table 2.
TABLE 2 Zein values N (g/L) for different surfactants
Surfactants with an N value less than 2 are "non-irritating" surfactants.
Examples 1 to 9
Examples of shampoo mousse compositions according to the invention, examples 1-9 have the formula shown in table 3.
Table 3 shampoo mousse composition recipe table (parts by weight)
Comparative example 1
Comparative example 1 is a shampoo mousse composition formulated in comparison to example 3 by replacing sodium methylcocoyltaurate with lauramidopropyl hydroxysultaine alone.
Examples 10 to 18
In the embodiments of the hair washing mousse according to the invention, the hair washing mousse compositions according to the embodiments 10-18 respectively comprise the hair washing mousse compositions according to the embodiments 1-9. In addition, the composition also comprises the following components in parts by weight: 100.3 parts of polyquaternium, 0.05 part of EDTA disodium, 0.3 part of allantoin, 0.12 part of citric acid, 2 parts of hydroxyethyl urea, 0.2 part of dipotassium glycyrrhizinate, 0.5 part of betaine, 0.2 part of wheat protein hydrolysate, 0.3 part of PPG-3 octyl ether, 0.6 part of phenoxyethanol, 0.4 part of potassium sorbate, 0.4 part of sodium benzoate and 52.5 parts of water.
Comparative example 2
A hair washing mousse comprising the hair washing mousse composition according to comparative example 1 and further comprising the following ingredients in parts by weight: 100.3 parts of polyquaternium, 0.05 part of EDTA disodium, 0.3 part of allantoin, 0.12 part of citric acid, 2 parts of hydroxyethyl urea, 0.2 part of dipotassium glycyrrhizinate, 0.5 part of betaine, 0.2 part of wheat protein hydrolysate, 0.3 part of PPG-3 octyl ether, 0.6 part of phenoxyethanol, 0.4 part of potassium sorbate, 0.4 part of sodium benzoate and 52.5 parts of water.
Performance test
1) Irritation test
The test is a blood vessel test of the chick embryo chorioallantoic membrane according to SN/T2329-2009, and the chick embryo chorioallantoic membrane blood vessel test is an in-vitro method of an eye stimulation test and is used for evaluating the stimulation degree of a tested body to eyes and evaluating the stimulation and safety degree of a product.
The experimental method comprises the following steps: using fertilized chicken embryos incubated for 10-12 days as experimental samples, marking the positions of air chambers on the surfaces of the eggshells, and stripping off the marked eggshells by using dental sawtooth bending forceps to expose white eggshell membranes; sucking a proper amount of sodium chloride solution with the mass fraction of 0.9% by using a suction pipe to wet the egg membrane, and pouring out the redundant solution; the intima is then carefully removed with forceps to ensure that the vascular membrane is not damaged. A loop of Teflon was placed on the intact chick embryo chorioallantoic membrane as the test area for the test sample. By utilizing the characteristics of integrity, clearness and transparency of chorioallantoic vessels of fertilized chick embryos, 0.3mL of each of the above examples 10-18 is taken, a 0.9 wt.% sodium chloride solution is used for diluting a sample until the concentration of the sample is 3 wt.%, a 0.9 wt.% sodium chloride solution is used as a negative control group, a 0.3 wt.% sodium hydroxide solution is used as a positive control group, the sample is dripped in a test area of the chick embryos, and the chick embryos are covered on an air chamber by a wet preservative film and then placed in a 37 ℃ incubator for culture for 30 min. The cultured chick embryos were irradiated with a lamp tube and the degree of damage to the blood vessels was observed and scored. The evaluation reference standard is shown in table 4, and the test results are shown in table 5.
TABLE 4 irritation evaluation criteria
Table 5 irritation test results
According to test results, the shampoo mousse prepared by compounding the selected surfactant is safe and non-irritant to human bodies.
2) Stability test
The stability tests of examples 10 to 18 and comparative example 2 were carried out, and the samples were stored at 25. + -. 2 ℃, 45. + -. 2 ℃ and-18. + -. 2 ℃ for 3 months, and the appearance, pH and viscosity values of the samples before and after storage were recorded, and the test results are shown in Table 6.
Table 6 stability test results
According to the test results, after the hair washing mousse disclosed by the invention is stored at room temperature, low temperature and high temperature, the pH value and viscosity of the hair washing mousse in the examples 10-18 are not changed greatly, which shows that the hair washing mousse disclosed by the invention has good stability.
3) Scalp repair Performance test
Scalp repair performance tests were performed on examples 10-18 and comparative example 2. The shampoo mousse is fitted to be used in combination with an aerosol can, valve and nozzle. 30 volunteers prone to alopecia were selected for testing, and the volunteers were divided into 10 groups at random, each group used the same sample for 60d, used once every 2d, combed with the same comb for 1min every morning, and the hair dropped was collected and recorded. The data are shown in table 7. The volunteer's experience of using the shampooed mousse was then recorded.
Table 7 statistical table (root) of hair loss number
As can be seen from table 7, examples 10 to 18 all had good ability to alleviate the occurrence of alopecia, and example 12 had the most significant alleviation effect.
4) Foaming test
The foam heights of examples 10-18 and comparative example 2 were tested using a Roche foam instrument. Each sample was tested in triplicate, averaged and reported in table 8.
TABLE 8 foam height (mm)
As can be seen from Table 8, the foam heights of the examples 10-18 are obviously higher than that of the comparative example 2, which shows that the shampoo mousse prepared by the formula disclosed by the invention has good foaming effect and is more convenient to use.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. A hair-washing mousse composition which is characterized by comprising a surfactant compound and active ingredient nanoliposomes; the surfactant formulation comprises cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl glutamate, TEA cocoyl alanine, and sodium methyl cocoyl taurate; the active ingredient nanoliposome comprises anise extract, fructan, houttuynia cordata extract, sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate; the surfactant compound comprises the following components in parts by weight: 12-18 parts of cocamidopropyl hydroxysultaine, 11-14 parts of a compound of sodium lauroyl sarcosinate and sodium lauroyl glutamate, 4-8 parts of cocoyl glutamic acid TEA salt, 4-8 parts of cocoyl alanine TEA salt and 2-4 parts of sodium methyl cocoyl taurate; the active ingredient nanoliposome comprises the following components in parts by weight: 0.4 to 0.8 portion of anise extract, 0.8 to 1.5 portions of fructan, 0.2 to 0.5 portion of heartleaf houttuynia herb extract, and 0.5 to 1.5 portions of complex of sodium cocoyl amino acid, sarcosine, potassium aspartate and magnesium aspartate; in the complex of the sodium cocoyl amino acid, the sarcosine, the potassium aspartate and the magnesium aspartate, the mass ratio of the sodium cocoyl amino acid, the sarcosine, the potassium aspartate and the magnesium aspartate is as follows: sarcosine: potassium aspartate: magnesium aspartate =2:2:1: 1.
2. The hair washing mousse composition according to claim 1, wherein the surfactant formulation comprises the following ingredients in parts by weight: 15 parts of cocamidopropyl hydroxysultaine, 12 parts of a compound of sodium lauroyl sarcosinate and sodium lauroyl glutamate, 5 parts of cocoyl glutamic acid TEA salt, 5 parts of cocoyl alanine TEA salt and 3 parts of sodium methyl cocoyl taurate.
3. A hair washing mousse comprising the hair washing mousse composition according to claim 1 or 2.
4. The hair washing mousse according to claim 3, further comprising polyquaternium-10, disodium EDTA, allantoin, citric acid, hydroxyethyl urea, dipotassium glycyrrhizinate, betaine, wheat hydrolyzed protein, PPG-3 octyl ether, phenoxyethanol, potassium sorbate, and sodium benzoate.
5. The hair washing mousse according to claim 4, further comprising the following ingredients in parts by weight: 100.1-0.5 part of polyquaternium, 0.03-0.07 part of EDTA disodium, 0.1-0.5 part of allantoin, 0.1-0.15 part of citric acid, 1.5-2.5 parts of hydroxyethyl urea, 0.1-0.3 part of dipotassium glycyrrhizinate, 0.3-0.7 part of betaine, 0.1-0.3 part of wheat protein hydrolysate, 0.1-0.5 part of PPG-3 octyl ether, 0.5-1 part of phenoxyethanol, 0.1-0.5 part of potassium sorbate and 0.1-0.5 part of sodium benzoate.
6. A method of preparing a hair wash mousse according to any one of claims 3-5, comprising the steps of:
(1) adding deionized water into an emulsifying pot, heating to 60-80 ℃, uniformly dispersing polyquaternium-10 in cold water, and then adding the mixture into the emulsifying pot for homogenizing for 2-3 minutes to obtain a mixed solution A;
(2) sequentially adding EDTA disodium and a surfactant compound into the mixed solution A, homogenizing for 3-8 minutes, and stirring for 20-40 minutes to obtain a mixed solution B;
(3) dispersing allantoin with cold water in advance, adding into the mixed solution B, and adding PPG-3 octyl ether;
(4) cooling to below 45 deg.C, sequentially adding the rest materials, wherein dipotassium glycyrrhizinate and sodium benzoate are dispersed with cold water, adding, and stirring to obtain the shampoo mousse.
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