JP2006028026A - Hair-growing agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a hair-growing agent which has excellent hair-growing effects such as an alopecia-preventing action, a hair-growing action. <P>SOLUTION: This hair-growing agent comprises inositol. Additionally, a hair-growing agent contains the above hair-growing agent as an active ingredient. The hair-growing agent can be applied to cosmetics containing quasi-medicines, medicines, and the like. The hair-growing agent is characterized by containing inositol and a phospholipid. Thereby, the hair-growing action of the inositol can further be improved. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a hair restorer. More specifically, the present invention relates to a hair restorer having a hair growth effect such as an excellent hair loss preventing action and a hair growth action.

  A hair restorer is a product that promotes hair growth or prevents hair loss, and in today's aging society, the demand is increasing year by year with increasing social stress. In general, the causes of head wrinkles and hair loss include activation of male hormones in organs such as hair follicles and sebaceous glands, insufficient supply of nutrients due to decreased blood flow to hair papilla and hair follicles, and keratinization of epithelial tissues Various causes are considered, such as excessive occurrence of dandruff due to abnormalities, excessive sebum secretion, abnormalities of the scalp due to generation of peroxides, imbalance in nutrition intake, and stress.

  Conventional hair restorers are generally prepared by removing elements that are thought to be the cause of wrinkles and hair loss, or by blending substances that have a mitigating action. Active ingredients used in hair restorers include blood circulation promoters (such as assembly extract, vitamin E, or derivatives thereof) that promote blood circulation in order to replenish the hair follicles with a lot of nutrients, and supply energy to the hair follicles Cell activators (such as pentadecanoic acid) that activate cells and sebaceous gland inhibitors (such as glycyrrhetinic acid) that are effective in preventing hair loss by suppressing excess sebum are used. In addition, substances such as dipotassium glycyrrhizinate and minoxidil are also known to be effective as hair restorers.

  However, even though many attempts have been made so far, hair-growth effects such as a hair loss prevention effect and a hair growth effect have not always been sufficient. The reason for this is that, as described above, the causes of wrinkles and hair loss are very diverse, and the mechanism of hair growth itself is also very complicated, so a hair restorer that focuses only on one aspect of those causes and mechanisms is not sufficient. It can be mentioned. Therefore, there is a need for continuous development of excellent hair restorers.

  On the other hand, inositol is also synthesized in the human body, but it is treated as a kind of vitamin because it cannot synthesize the necessary amount, and is generally known as a kind of vitamin B group indispensable for promoting cell growth. In addition, it is said to have effects such as liver cirrhosis and fatty liver prevention, arteriosclerosis prevention, growth promoting action, etc. when ingested into the body, and as a preventive / therapeutic agent for fatty liver, cirrhosis, etc. It is widely used for essential vitamins and the like (see, for example, Patent Document 1). In addition, rice bran has been known to contain fats and oils, vitamin B, minerals, etc., and it gives oil, moisture and nutrients to the skin, improving moisture and moisturizing properties, and preventing the decrease in elasticity. It is added to skin cosmetics.

  Furthermore, in order to enhance the above-mentioned effect, it contains a cosmetic (see Patent Document 2) characterized by using a polysaccharide extracted from rice bran as an active ingredient, and a water-soluble antioxidant obtained from rice bran. A cosmetic (see Patent Document 3) characterized by the above is known.

  Furthermore, inositol has been found to have high moisture retention, moisturizing effect and nutritional supplement, skin cleansing agents such as soap, body shampoo, hand soap, lotion, emulsion, lotion, cream, pack, cleansing cream, Skin cosmetics such as foaming agents, makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, hair makeup such as shampoos, rinses, hair tonics, treatments, hair creams, sprays, foaming agents, hair nourishing and hair removal agents Although the technique mix | blended with the pigment | dye etc. is disclosed (refer patent document 4), it is not known that inositol has the outstanding hair growth effect | action.

Japanese Patent Laid-Open No. 7-330643 JP-A 64-66106 JP-A-2-53705 Japanese Patent Application Laid-Open No. 10-114641

  This invention is made | formed in view of the said situation, The objective is to provide the hair restorer which has the outstanding hair growth effects, such as a hair loss prevention effect and a hair growth action.

  As a result of intensive studies to solve the above problems, the present inventors have found that inositol has excellent hair-growth activity, and have completed the present invention.

  That is, the present invention is a hair restorer comprising inositol.

  Moreover, this invention is the hair restorer which contains the said hair restorer as an active ingredient.

  Moreover, this invention is a hair restorer containing inositol and phospholipid, and it is preferable that the said phospholipid is phosphatidylinositol.

  According to the present invention, it is possible to obtain a hair growth agent having a hair growth effect such as an excellent hair loss prevention effect and a hair growth effect.

  Hereinafter, embodiments of the present invention will be described in detail.

Inositol according to the present invention is a known substance isolated in 1850 for the first time from bovine heart extract. The inositol is a cyclic hexahydric alcohol represented by C ₆ H ₆ (OH) ₆ , and there are nine stereoisomers. Any of them may be used in the present invention.

  Inositol is produced by extracting from rice bran, for example, a large amount of phytate calcium and magnesium mixed salt (phytin) in rice bran, and further decomposing and purifying the extracted phytin. It can also be obtained by chemical synthesis. Moreover, what was obtained by the fermentation method can also be used. The present invention is not limited to these.

  The inositol according to the present invention has an excellent hair growth action as will be demonstrated later. Therefore, the hair restorer of this invention consists of the said inositol.

  In this invention, inositol which is the hair restorer which concerns on this invention is contained as an active ingredient, and it prepares in a hair restorer. The hair-restoring agent exhibits a hair-restoring effect by external administration or the like.

  The hair restorer of the present invention is applied as, for example, cosmetics, pharmaceuticals and the like including quasi drugs.

  When preparing the hair restorer which contains the said inositol which concerns on this invention as an active ingredient, as content of inositol, 0.00001-15 mass% is preferable among hair restorer whole quantity. More preferably, it is 0.0001-10 mass%.

  In preparing the hair restorer, inositol and phospholipid can be used in combination, thereby improving the hair-restoring action of inositol.

  The phospholipid is not particularly limited as long as it is used in cosmetics, quasi drugs, pharmaceuticals, and the like. In the present invention, phospholipid is so-called lecithin in a broad sense and has a concept including natural phospholipids, phospholipid derivatives such as hydrogenated phospholipids, synthetic phospholipids, and the like. Examples of phospholipids include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and sphingomyelin, hydrogenated phospholipids in which unsaturated carbon chains in natural phospholipids are saturated with hydrogen, and dioleylphosphatidylcholine. Synthetic phospholipids and the like. In the present invention, one of these phospholipids may be used alone, or two or more thereof may be mixed and used, but it is general to use a mixture. In the present invention, it is preferable to use phosphatidylinositol among the phospholipids, and the effects of the present invention are particularly exhibited. Phosphatidylinositol may be used alone as a phospholipid but is generally used in the form of a mixture with other phospholipids as described above.

  Since the phospholipid of the present invention is commercially available, a commercially available product can be used. Examples of commercially available products include, for example, Resinol S-PIE, WS-50, S-10, S-10E, S-10EX, S-10M, SH50, and LL-20 manufactured by Nikko Chemicals. Etc. In the present invention, it is preferable to use Resinol S-PIE and WS-50 containing phosphatidylinositol.

  The content of the phospholipid in the case of preparing a hair restorer using inositol and phospholipid in combination is preferably 0.001 to 10% by mass in the total amount of the hair restorer.

  Further, in the preparation of the hair growth agent, other hair growth and hair growth components that are already known to have hair growth, hair growth, hair growth promotion and hair restoration effects may be used in combination with the components according to the present invention. it can. Moreover, the component known as a transdermal absorption agent can also be used together, and is a preferable aspect.

  Furthermore, in the preparation of the hair restorer, components usually used in cosmetics, pharmaceuticals and the like can be blended within a range that does not impair the effects of the present invention.

  For example, for cosmetics, for example, oil, surfactant, moisturizer, polyhydric alcohol, thickener, water-soluble polymer, film-forming agent, powder, pigment, dye, lower alcohol, saccharide, ultraviolet absorber, Amino acids, vitamins, skin activators, plant extracts, organic acids, organic amines, sequestering agents, pH adjusters, antioxidants, refreshing agents, fragrances, water and the like.

  For pharmaceutical products, for example, excipients, stabilizers, wetting agents, emulsifiers, absorption promoters, pH adjusters, surfactants, diluents, solubilizers, preservatives, fragrances, coloring agents, etc. Various additive components can be mentioned.

  The hair restorer of the present invention can be prepared according to a conventional method by blending the above components.

  Hereinafter, the present invention will be specifically described with reference to examples. In addition, a compounding quantity is the mass%.

[Example 1] Hair growth activity Hair growth activity was evaluated by the method described below.

(Test method)
Using C3H mice, the hair on the back was shaved with an electric clipper, and then a 1% by mass aqueous solution of each sample (in the case of inositol + phospholipid, 1% by mass aqueous solution, respectively) was administered 5 days a week for 4 weeks. After the administration, the lightness of the skin color at the hair removal site was measured using a color difference meter. It has been found that the lightness of the skin color decreases with hair growth, and the decrease in lightness is a signal of hair growth. As the phospholipid, commercially available Resinol S-PIE (manufactured by Nikko Chemicals) was used.

(result)
Table 1 shows the measurement results of the lightness of the skin color. As is clear from Table 1, inositol showed an excellent decrease in lightness even when compared with other hair growth agents such as minoxidil. In particular, an effect superior to that of minoxidil, which is known to be excellent, was observed. In addition, a decrease in brightness was observed in the system combined with phospholipid.

[Example 2] Hair papilla cell proliferation test The effectiveness of the hair growth effect was evaluated by examining the increase in hair papilla cells.

(Test method)
Rat hair papilla cells were cultured in DMEA (Dulbecco modified Eagle medium) containing 10% FCS (fetal bovine serum). Next, each sample was dissolved in 10 μg / ml DMEA medium, the medium of hair papilla cells was removed, and after washing with phosphate buffer [PBS (−)], the lysis medium for each sample was added and cultured at 37 ° C. for 3 days. did. Thereafter, 100 μL of formazan extract was added and shaken. The absorbance at 570 nm was measured using a microplate reader. The cell growth degree of each sample was calculated with the cell growth degree of the control medium as 100. As the phospholipid, commercially available Resinol S-PIE (manufactured by Nikko Chemicals) was used.

(result)
The measurement results of the cell proliferation degree are shown in Table 2. As is apparent from Table 2, inositol was superior in the increase in hair papilla cells, and the effect was further improved in the system combined with phospholipid.

[Embodiment 3] Human hair growth promotion effect Human hair hair growth-promoting effect Hair shaved at 5 cm above the ears of the heads of 15 test subjects who are male pattern baldness patients were shaved into a circular shape having a diameter of 1 cm at two left and right positions. At the test site, minoxidil and inositol preparations (both 1% by weight aqueous solution), and inositol + phospholipid preparations (aqueous solutions each having a concentration of 1% by weight) were each twice a day on the left side of 5 people each morning. 3 ml was applied and compared to the untreated right side. On the 28th day after the start of the test, the effect was determined by shaving 20 hairs on each of the left and right test sites, and averaging the length of 20 hairs on the left side (with minoxidil and inositol preparations applied) (B) A value obtained by dividing the value by the average value (A) of the lengths of 20 right-side (untreated) hairs was evaluated. The determination result was shown as an average value of (B) / (A) of five test subjects. As the phospholipid, commercially available Resinol S-PIE (manufactured by Nikko Chemicals) was used. The results are shown in Table 3.

  As can be seen from Table 3, both the inositol preparation and the inositol + phospholipid preparation showed an excellent hair-growth effect compared to the minoxidil preparation. In particular, the inositol + phospholipid preparation had an excellent effect.

[Example 4] Practical test 5 subjects each of the inositol preparation and inositol + phospholipid preparation of Example 3 twice a day for 3 consecutive months for 10 test subjects who are male pattern baldness patients. The effect after applying to the part was evaluated. As for the test results, for each of the hair growth effect and the hair loss prevention effect, effective answers were obtained such as “hair growth became bristle or increased” and “hair loss decreased”. As the phospholipid, commercially available Resinol S-PIE (manufactured by Nikko Chemicals) was used.

  Below, the formulation example of the hair restorer of this invention is shown as an Example.

[Example 5] Hair restorer component blending amount (% by mass)
Inositol 5.0
Phospholipid (Note) 1.0
Dipropylene glycol 7.0
Vitamin E 0.1
Diphenhydramine hydrochloride 0.1
Dipotassium glycyrrhizinate 0.1
Methylparaben 0.2
Menthol 0.1
Ethanol 50.0
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note) Resinol S-PIE (Nikko Chemicals)

[Example 6] Hair restorer component blending amount (% by mass)
Inositol 0.1
Phospholipid (Note) 0.1
Propylene glycol 3.0
1,3-butylene glycol 2.0
Vitamin E 0.3
Pepper tincture 0.1
Diphenhydramine hydrochloride 0.1
Dipotassium glycyrrhizinate 0.1
Methylparaben 0.2
Menthol 0.1
Ethanol 50.0
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note) Resinol S-PIE (Nikko Chemicals)

[Example 7] Hair restorer component blending amount (% by mass)
Inositol 1.0
Phospholipid (Note) 5.0
Methylphenylpolysiloxane 1.0
Liquid paraffin 5.0
Stearyl alcohol 2.0
Propylene glycol 3.0
1,3-butylene glycol 2.0
Glycerin 1.0
Stearyltrimethylammonium chloride 0.5
Vitamin E 0.3
Collagen hydrolyzate 1.0
Pepper tincture 0.1
Diphenhydramine hydrochloride 0.1
Methylparaben 0.2
Menthol 0.1
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note) Resinol S-PIE (Nikko Chemicals)

[Example 8] Hair restorer component blending amount (% by mass)
Inositol 3.0
Phospholipid (Note 1) 0.8
Methylphenylpolysiloxane 1.0
Pyridoxine hydrochloride 0.05
Placenta extract 1.0
Yeast extract 0.1
Ethanol 30.0
Menthol 0.1
1,3-butylene glycol 3.0
Ascorbic acid 1.0
Dipotassium glycyrrhizinate 0.1
2-Methacryloyloxyethyl phosphorylcholine copolymer (Note 2)
1.0 (actual part 0.05)
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note 1) Resinol S-PIE (Nikko Chemicals)
(Note 2) Blended with lipid-PMB (5% aqueous solution) (manufactured by NOF Corporation)

[Example 9] Hair restorer component blending amount (% by mass)
Inositol 2.0
Phospholipid (Note 1) 0.7
Hydrogenated soybean phospholipid 0.5
1,3-butylene glycol 3.0
1,2-hexanediol 1.0
2-Methacryloyloxyethyl phosphorylcholine copolymer (Note 2)
1.0 (actual part 0.05)
1,1′-methylene-bis (4-isocyanatocyclohexane) / polyethylene glycol copolymer (Note 3) 0.5
Polyoxyethylene (60) hydrogenated castor oil 0.1
Pyridoxine hydrochloride 0.05
Placenta extract 0.2
Yeast extract 0.1
Ethanol 20.0
Menthol 0.1
Ascorbic acid 0.5
Dipotassium glycyrrhizinate 0.1
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note 1) Resinol S-PIE (Nikko Chemicals)
(Note 2) Blended with lipid-PMB (5% aqueous solution) (Nippon Yushi Co., Ltd.) (Note 3) Display name; (PEG-8 / SMDI) copolymer (molecular weight 1800)

[Example 10] Hair restorer component blending amount (% by mass)
Inositol 1.5
1,3-butylene glycol 3.0
1,2-hexanediol 1.0
2-Methacryloyloxyethyl phosphorylcholine copolymer (Note)
3.0 (0.15 actual)
Ethanol 20.0
Vitamin E 0.3
Placenta extract 1.0
Phenoxyethanol 0.4
Perfume Appropriate amount of purified water Remaining amount
Total 100.0

(Note) Contains Lipidure-PMB (5% aqueous solution) (manufactured by NOF Corporation).

Claims (4)

  Hair restorer consisting of inositol.   A hair restorer comprising the hair restorer according to claim 1 as an active ingredient.   A hair restorer comprising inositol and phospholipid.   The hair restorer according to claim 3, wherein the phospholipid is phosphatidylinositol.