CN111603433B - Mild washing and protecting article for infants and preparation method thereof - Google Patents

Mild washing and protecting article for infants and preparation method thereof Download PDF

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CN111603433B
CN111603433B CN202010478122.7A CN202010478122A CN111603433B CN 111603433 B CN111603433 B CN 111603433B CN 202010478122 A CN202010478122 A CN 202010478122A CN 111603433 B CN111603433 B CN 111603433B
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CN111603433A (en
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陈淘
吴依娜
陈国祥
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Hangzhou Xinyue Cosmetic Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/596Mixtures of surface active compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

The invention discloses a mild washing and nursing article for infants and a preparation method thereof. The washing and protecting article comprises the following components in percentage by weight: group A: 1-15% of glycerol; 1-10% C12-14 hydroxyalkyl hydroxyethyl sarcosine; 1-10% of sodium laureth-4 carboxylate; 1-10% of cocoyl amphodiacetate disodium; group B: 1.1 to 25 percent of surfactant; 0.1-1% of EDTA disodium; 0.1-1% of allantoin; group C: 1-3% of a thickening agent; group D: 0.1-5% of a first skin feel modifier; 0.1-1% of a second skin feel modifier; 0.1 to 1 percent of polyquaternium; group E: 0.01 to 0.1 percent of pH regulator; and F group: 0.21 to 6.1 percent of skin conditioner; 0.01 to 0.3 percent of polyaminopropyl biguanide; inulin 0.08-0.7%; 0.02-0.3% of fructo-oligosaccharide; pseudoalteromonas ferment product extract 0.1-5%; lactobacillus fermentation lysate 0.1-5%; the balance being water. The invention can be used for infant washing and nursing, and has the advantages of repairing and strengthening skin barrier and promoting water-oil balance.

Description

Mild washing and caring product for infants and preparation method thereof
Technical Field
The invention relates to the field of daily washing and caring products, in particular to a mild washing and caring product for infants and a preparation method thereof.
Background
When infants are in a key growth and development stage, the skin cuticle of the infants is thin, the oil secretion amount is small, and the overall skin is sensitive. In order to protect the young and tender skin of the infants, the infant washing and caring product is a single product, and is mild and non-irritant.
Chinese invention with publication number CN107773483A and publication date of 2018, 3 and 9 discloses a bath product for infant care. The bubble bath product comprises the following components in parts by weight: 60-96 parts of honeysuckle stem extract, 60-96 parts of monkshood extract, 54-84 parts of litsea cubeba extract, 54-84 parts of maple leaf extract, 48-72 parts of uncaria extract, 24-48 parts of folium Malloti Apeltae extract, 24-48 parts of sarcandra glabra extract, 24-48 parts of wild raspberry extract and 24-48 parts of radix fici simplicissimae extract.
The prior art is mainly used for treating the skin disease of infants, does not belong to daily used washing and caring articles, and has short application time. The invention discloses an antibacterial infant care lotion and application thereof, wherein the publication number is CN110755331A, and the publication date is 2020, 02 and 07 days.
In the prior art, the most obvious effect is mild bacteriostasis, the lasting effect of bacteriostasis depends on the retention time of the bacteriostasis component, and once the component volatilizes or is separated from the surface of the skin, the bacteriostasis effect is not generated any more. Therefore, it is more important to enhance the skin barrier of the skin itself, which can protect the young skin of the infant at any time.
Disclosure of Invention
In view of the defects in the prior art, the first object of the invention is to provide a mild washing and nursing product for infants, which has the advantages of repairing and strengthening the skin barrier, and moisturizing and moistening the skin.
A second object of the present invention is to provide a mild toiletry for infants and a method for preparing the same, which has the advantage of obtaining a uniform and stable toiletry product.
In order to achieve the first object, the invention provides the following technical scheme: a mild washing and nursing product for infants comprises the following components in percentage by weight:
group A:
1-15% of glycerol;
1-10% C12-14 hydroxyalkyl hydroxyethyl sarcosine;
1-10% of sodium laureth-4 carboxylate;
1-10% of cocoyl amphodiacetate disodium;
group B:
1.1 to 25 percent of surfactant;
0.1-1% of EDTA disodium;
0.1-1% of allantoin;
group C:
1-3% of a thickening agent;
group D:
0.1-5% of a first skin feel modifier;
0.1-1% of a second skin feel modifier;
0.1 to 1 percent of polyquaternium;
group E:
0.01 to 0.1 percent of pH regulator;
and F group:
0.21-6.1% of skin conditioner;
0.01 to 0.3 percent of water polyaminopropyl biguanide;
inulin 0.08-0.7%;
0.02-0.3% of fructo-oligosaccharide;
pseudoalteromonas ferment product extract 0.1-5%;
lactobacillus fermentation lysate 0.1-5%;
the balance of water;
the skin conditioner comprises a first mixture 0.01-0.1 wt%, a second mixture 0.05-0.5 wt%, and a third mixture, wherein the first mixture comprises sunflower seed oil 65-82 wt% and prickly pear fruit extract in balance; the second mixture comprises 30-50% of flos Matricariae Chamomillae extract and the balance of water; the third mixture comprises 5-12% butylene glycol, 50-70% orange fruit extract and balance water.
By adopting the technical scheme, the group A mainly comprises a humectant and a surfactant, the group B mainly comprises the surfactant and a skin conditioner, the group D mainly comprises the skin feel conditioner, and the group F comprises the skin conditioner and a flora regulating component on the surface of the skin.
In the skin conditioner, the first mixture contains sunflower seed oil and a mesona chinensis benth fruit extract, the sunflower seed oil contains a large amount of linoleic acid which is used as a micromolecular oil substance, other components are easy to permeate into the skin, and the skin conditioner has hydrophilicity and can realize the long-acting moisturizing effect; can also repair skin barrier and regulate water and oil balance. The extract of Opuntia Dillenii (Ker-Gawl.) Hayata can promote the production of skin growth factor, has skin activating effect, and can be used in combination with sunflower seed oil to accelerate skin barrier repair process.
The chamomile extract in the second mixture contains flavonoids and amino acids, has the effects of relieving skin, resisting skin sensitivity, resisting inflammation, resisting bacteria and resisting oxidation, and can be used for deeply moisturizing and regulating the water-oil balance of the skin to a certain degree; the first mixture can enhance the moisturizing effect and enhance the skin barrier. The orange fruit extract of the fourth mixture may stimulate cell proliferative activity, which may further accelerate the skin barrier repair process.
Inulin and fructo-oligosaccharide are water-soluble dietary fibers, belong to prebiotics and can effectively promote the growth of probiotics on the skin epidermis. The pseudoalteromonas ferment product extract is an extracellular polymer which can reduce redundant oil and luster of the epidermis and shrink pores. The lactobacillus fermentation lysate is all active ingredients synthesized by thalli in the fermentation process, can directly act on the skin and provides nutrition for the skin; in addition, when the flora is unbalanced outside the skin, the composition can be used as a component for regulating the flora, and plays a role in maintaining stability.
The sunflower seed oil can permeate amino acids, sterols, fatty acids, nucleotides and the like in long-acting moisture-retaining components and lactobacillus fermentation lysate into skin, provide energy and nutrient substances for cell repair and proliferation, accelerate repair of skin barrier, and balance water and oil and relieve skin by matching with the opuntia ficus-indica fruit extract and the orange extract. On the other hand, when amino acids, sterols, fatty acids, and nucleotides enter the skin, substances such as phospholipids enter the skin to fill the sebaceous membrane or fill the stratum corneum with intercellular lipids. In addition, allantoin has a hydrophilic effect, can soften cuticle protein, can further improve the repair and supplement of sebum by matching with sunflower seed oil, and is more favorable for the diffusion and permeation of the citrus junos fruit extract after softening the cuticle protein, thereby improving the promotion effect on cell proliferation.
In general, an interaction between group F and allantoin is formed. Allantoin is mixed with the first mixture, and can permeate into stratum corneum, soften stratum corneum protein, and open stratum corneum channel; and the third mixture is matched to promote the generation of skin growth factors on the basis of regulating the water-oil balance of the skin, and the lactobacillus fermentation lysate is matched to promote cell proliferation, repair and strengthen the skin barrier under the condition of nutrient substances, and simultaneously can repair the surface sebum layer and fill the cuticle as intercellular lipid. The skin barrier is simultaneously repaired from the inner side and the outer side (a sebum layer and a cuticle), and the skin barrier protection capability of the infant is improved. The redundant grease can be removed by the pseudoalteromonas fermentation product extract, and finally the water-oil balance effect is achieved.
C12-14 hydroxyalkyl hydroxyethyl sarcosine, sodium laureth-4 carboxylate and disodium cocoyl amphodiacetate are mild and non-irritating surfactants. The C12-14 hydroxyalkyl hydroxyethyl sarcosine has cleaning and foaming effects, and the disodium cocoyl amphodiacetate has foam increasing and cleaning effects; the sodium laureth-4 carboxylate has the advantages of foaming and foam stabilizing effects, good compatibility, reduced irritation of other surfactants, and no irritation to cleaning products.
Polyquaternium-52 improves the softness of the foam and gives a smooth feel when rinsed. The aminopropyl biguanide is extremely mild preservative because its terminal guanidine group can interact with the biological radicals and elements to produce destructive effect, and the film formed by the polymer blocks the respiratory passage of the microorganism, so that the microorganism is rapidly suffocated and killed.
Further, the skin conditioner consists of a first mixture accounting for 0.01-0.1% of the total amount of the washing care product, a second mixture accounting for 0.05-0.5%, a fourth mixture accounting for 0.05-0.5% of the total amount of the washing care product and the balance of a third mixture; the fourth mixture consists of 5 to 10 percent of butanediol, 25 to 45 percent of white-flower spring yellow chrysanthemum and the balance of water.
By adopting the technical scheme, the fourth mixture is added, and the dosage of various components in the skin conditioner is limited. The white flower spring yellow chrysanthemum can inhibit capillary permeability, has an anti-inflammatory effect, can eliminate free radicals, and has oxidation resistance; when the allantoin softens the proteins of the stratum corneum to open the channels, the white-flowered chrysanthemum flower has the inhibitory effect on the capillaries, so that the possible damage to the dermis of the skin caused by the outside can be reduced, and the mildness and the safety of the washing and caring product are improved.
Further, the weight part ratio of the first mixture to the second mixture to the fourth mixture to the third mixture is (0.2-0.5) 1.
By adopting the technical scheme, the experimental data show that the combination of the first mixture, the second mixture, the fourth mixture and the third mixture in the preferable range can improve the overall skin barrier repair strengthening effect of the washing and protecting product, moisturize the skin and promote the water-oil balance.
Further, the second skin feel modifier is composed of 45-65% of avocado oil PEG-11 esters and balance water.
By adopting the technical scheme, the avocado oil PEG-11 esters can be used as emollients, conditioners, skin softening agents and the like and can be used for solubilizing oil substances; the esters can form oil film on skin, and can be used for maintaining skin moistening feeling after drying.
Further, the first skin feel modifier consists of 35-50% of glycosyl trehalose, 12-25% of hydrogenated starch hydrolysate and the balance of water; the mass part ratio of the first skin feeling modifier to the second skin feeling modifier to the polyquaternium-52 is 4.
By adopting the technical scheme, the glycosyl trehalose can form a protective film on the surface of the skin, resist the skin aging phenomenon and keep the skin vitality. The skin care product can effectively relieve and tighten the skin, increase the smoothness of the skin, moisten the skin, soften the touch of the skin and endow the skin with a smooth feeling. Can protect cells irradiated by ultraviolet rays and activate cells; has high moisture keeping effect, can prevent skin dryness, and has antiinflammatory effect. The hydrogenated starch hydrolysate is a mixture of sorbitol, mannitol, maltitol, and reducing oligosaccharide, and has low viscosity, high hygroscopicity, and good moisture keeping effect. Can achieve good moisturizing effect after being mixed with glycosyl trehalose and water. The first skin feel modifier, the second skin feel modifier and polyquaternium-52 in the preferred range are mutually matched to endow the washing and care product with smooth skin feel during washing and improve the skin moisturizing and moistening feel after washing.
Further, the surfactant in group B consisted of decyl glucoside, 1-10% cocamidopropyl betaine, and poloxamer 184, the balance, at 1-10% by total weight of the cleaning product.
By adopting the technical scheme, decyl glucoside has the characteristics of common nonionic and anionic surfactants, has low surface tension, rich, fine and stable foam, strong alkali and strong acid resistance and strong wetting power, can be compounded with various surfactants, and has obvious synergistic effect. Cocamidopropyl betaine is a zwitterionic surfactant that significantly improves the softness, conditioning and low temperature stability of cleaning products. Poloxamer 184 is also a mild and non-irritating surfactant, and is a good cleanser, surfactant and suspending agent. By matching with the surfactant of the group A, the washing and caring product with good cleaning capability, easy foaming and fine and rich foam can be obtained.
Further, the thickener is PEG-120 methyl glucose dioleate.
By adopting the technical scheme, the PEG-120 methyl glucose dioleate is used as a non-ionic thickening agent, is a non-normal-temperature and extremely-efficient thickening agent, can reduce the irritation caused by the surfactant, and does not reduce the foam height.
In order to achieve the second object, the invention provides the following technical scheme: a preparation method of a mild washing and nursing product for infants comprises the following steps:
s1: uniformly mixing water and the group A raw materials for later use;
s2: adding the raw materials of the group B into the mixture obtained in the step S1, heating to 70-80 ℃, and uniformly stirring;
s3: adding the raw materials in the group C into the mixture obtained in the step S2, preserving heat and uniformly stirring;
s4: cooling to 55-60 ℃, adding the group D raw materials into the mixture obtained in the step S3, preserving heat and uniformly stirring;
s5: cooling to 40-50 ℃, adding a pH regulator into the mixture obtained in the step S4, preserving heat and uniformly stirring;
s6: adding the F group raw materials into the mixture obtained in the step S5, preserving heat and uniformly stirring;
s7: and (4) cooling the mixture obtained in the step (S6) to 35 +/-2 ℃, sieving the mixture by using a sieve of 80-100 meshes, discharging and filling.
By adopting the technical scheme, the uniform and stable washing and protecting article is obtained.
In conclusion, the invention has the following beneficial effects:
1. in the invention, the first mixture, the second mixture, the third mixture and allantoin are preferably adopted to permeate into the stratum corneum, soften stratum corneum protein, open stratum corneum channels and promote the generation of skin growth factors on the basis of regulating the water-oil balance of the skin; under the condition of nutrient substances, the skin barrier repairing and strengthening agent can promote cell proliferation, repair surface sebum layers and fill intercellular lipid in the cuticle, repair the skin barrier from the internal and external aspects, and improve the skin barrier protection capability of infants.
2. The fourth mixture is preferably adopted in the invention, when allantoin softens stratum corneum protein to open channels, the inhibition effect of the chamomile flower on capillary vessels can reduce the damage to the dermis of the skin possibly caused by the outside, and the mildness and the safety of the washing and caring product are improved.
3. In the present invention, the first skin-feel modifier, the second skin-feel modifier and polyquaternium-52 are preferably used to impart a smooth skin feel to the cleansing product during rinsing and to improve the post-wash skin-moisturizing feel.
Detailed Description
Examples 1 to 10: a mild toiletry for infants, examples 1-5, 10 comprising the components and corresponding masses shown in table 1, and prepared by the following sequential steps:
s1: putting water and the raw materials of the group A into a stirring pot, and stirring for 30min at the speed of 15 r/min;
s2: adding group B raw materials into a stirring pot, heating to 75 ℃, preserving heat, and stirring for 30min at the speed of 15 r/min;
s3: continuously adding the group C raw materials into the stirring pot, and stirring for 30min at 20 r/min;
s4: cooling the materials in the stirring pot to 60 deg.C, maintaining the temperature, adding group D materials, and stirring at 20r/min for 10min;
s5: cooling the stirring pot to 45 ℃ and preserving heat, adding a pH regulator, and stirring for 10min at the speed of 20 r/min;
s6: continuously adding the F group of raw materials into the stirring pot, and stirring for 20min at the speed of 30 r/min;
s7: and cooling the materials in the stirring pot to 35 +/-2 ℃, sieving the materials by a 100-mesh sieve, discharging and filling.
TABLE 1 examples 1-5, 10 components and corresponding masses (kg)
Figure BDA0002516438360000061
In the above examples, the thickener was PEG-120 methyl glucose dioleate.
In example 1, the surfactant consisted of 10kg of decyl glucoside, 2kg of cocamidopropyl betaine, and the balance poloxamer 184. The first skin feel modifier is glyceryl oleate and the second skin feel modifier is an olive oil PEG-7 ester. The skin conditioner consists of 0.01kg of a first mixture consisting of 65% sunflower seed oil and the balance opuntia tuna fruit extract, 0.5kg of a second mixture consisting of 50% chamomile extract and the balance water, and the balance of a third mixture consisting of 10% butylene glycol, 60% orange fruit extract and the balance water.
In example 2, the surfactant consisted of 10kg of decyl glucoside, 8kg of cocamidopropyl betaine and the balance poloxamer 184. The first skin feel modifier is glyceryl oleate, and the second skin feel modifier is composed of 65% avocado oil PEG-11 esters and balance water. The skin conditioner consists of 0.1kg of a first mixture consisting of 82% sunflower seed oil and the balance opuntia tuna fruit extract, 0.05kg of a second mixture consisting of 40% chamomile extract and the balance water, and the balance of a third mixture consisting of 5% butylene glycol, 50% orange fruit extract and the balance water.
In example 3, the surfactant consisted of 1kg of decyl glucoside, 10kg of cocamidopropyl betaine and the balance poloxamer 184. The first skin feel modifier is an olive oil PEG-7 ester, and the second skin feel modifier is shea butter. The skin conditioner consists of 0.05kg of a first mixture consisting of 75% sunflower seed oil and the balance opuntia tuna fruit extract, 0.2kg of a second mixture consisting of 30% chamomile extract and the balance water, and the balance of a third mixture consisting of 10% butylene glycol, 55% orange fruit extract and the balance water.
Example 4: the surfactant is decyl glucoside. The first skin feel modifier is glyceryl oleate, and the second skin feel modifier is composed of 60% avocado oil PEG-11 esters and balance water. The skin conditioner consists of 0.08kg of a first mixture consisting of 70% sunflower seed oil and the balance prickly pear fruit extract, 0.5kg of a second mixture consisting of 45% chamomile extract and the balance water, and the balance of a third mixture consisting of 12% butylene glycol, 70% orange fruit extract and the balance water.
Example 5: the surfactant consisted of 8kg of decyl glucoside, the balance being cocamidopropyl betaine. The first skin feeling regulator consists of 30% glycosyl trehalose, 30% hydrogenated starch hydrolysate and the balance of water, and the second skin feeling regulator is shea butter. The skin conditioner consists of 0.05kg of a first mixture consisting of 75% sunflower seed oil and the balance of opuntia tuna fruit extract, 0.2kg of a second mixture consisting of 30% chamomile flower extract and the balance of water, 0.05 a fourth mixture consisting of 10% butylene glycol, 55% orange fruit extract and the balance of water, and the balance of a third mixture consisting of 10% butylene glycol, 40% chamomile flower and the balance of water.
Example 6 differs from example 5 in that the surfactant is cocamidopropyl betaine. The first skin feel modifier is an olive oil PEG-7 ester, and the second skin feel modifier is composed of 45% pear oil PEG-11 ester and the balance of water. The fourth mixture in the skin conditioner is 0.2kg in weight, and the fourth mixture is composed of 5% of butanediol, 25% of white-flowered chrysanthemum flower and the balance of water.
Example 7 differs from example 5 in that the surfactant consists of 10kg of decyl glucoside, 8kg of cocamidopropyl betaine and the balance poloxamer 184. The first skin feel modifier is glyceryl stearate and the second skin feel modifier is shea butter. The skin conditioner comprises a first mixture, a second mixture, a fourth mixture and a third mixture, wherein the mass part ratio of the first mixture to the second mixture to the fourth mixture is 0.5.
Example 8 differs from example 7 in that example 8 differs from example 5 in that the surfactant consists of 1kg of decyl glucoside, 10g of cocamidopropyl betaine and the balance poloxamer 184. The first skin feel modifier consists of 55% glycosyl trehalose, 10% hydrogenated starch hydrolysate and balance water, and the second skin feel modifier consists of 50% avocado oil PEG-11 esters and balance water. The ratio of the first mixture, the second mixture, the fourth mixture and the third mixture in the skin conditioner is (weight parts) from 0.2.
Example 9 differs from example 8 in that the first skin feel modifier consists of 35% glycosyl trehalose, 25% hydrogenated starch hydrolysate and balance water. The ratio of parts by mass of the first mixture, the second mixture, the fourth mixture and the third mixture in the skin conditioner is (0.25).
In example 10, the surfactant consists of 5kg of decyl glucoside, 6g of cocamidopropyl betaine, and the balance poloxamer 184. The first skin feel modifier consisted of 50% glycosyl trehalose, 12% hydrogenated starch hydrolysate and balance water and the second skin feel modifier and skin conditioner were the same as in example 9.
Comparative examples 1 to 4: the difference from example 1 is that the components included and the corresponding masses are shown in table 2:
TABLE 2 comparative examples 1-4 compositions and corresponding masses (kg)
Figure BDA0002516438360000091
Characterization experiment:
1. high and Low temperature stability test
Subject: examples 1-10, for a total of 10 experimental samples.
The experimental method comprises the following steps: the pH value, cold resistance and heat resistance of the experimental sample are tested according to the national standard QB/T34857-2017.
Heat resistance: keeping the temperature at (40 +/-2) ℃ for 24h, and comparing the temperature after returning to the room temperature with that before the experiment to determine whether the temperature is not obviously changed (no layering, no precipitation, no odor and color change, and no turbidity of a transparent product). Cold resistance: keeping the temperature at (-5 +/-2) ℃ for 24h, and after the temperature is restored to the room temperature, comparing the temperature with that before the experiment to determine whether the temperature has no obvious change (no layering, no precipitation, no odor and color change, and no turbidity of transparent products).
The experimental results are as follows: the results of the high and low temperature stability tests are reported in table 3.
TABLE 3 record of the results of the high and Low temperature stability test
Figure BDA0002516438360000101
And (3) data analysis: as can be seen from the above table, the examples have excellent stability against high and low temperatures, and the pH value is within the required value, which can reach the national standard.
2. Skin barrier repair enhancement effect experiment
Subject: examples 1-10 and comparative examples 1-4, for a total of 14 experimental groups.
The experimental method comprises the following steps: selecting 90 children aged 0-3 years and having no obvious skin damage or skin diseases, and dividing into 14 groups and 5 children, wherein each group is used in accordance with examples 1-10 and comparative examples 1-4; frequency of use: the children were washed with the corresponding test samples on body and face twice daily for 18-20 pm for 30 days (15 times total). Before using the corresponding experimental sample, testing two positions of the front cheek and the front arm of the child and calculating a mean value record; after 5 uses, the test is carried out at 22 points of the day and the average value record is calculated; after 15 uses, the test was performed at 22 o' clock of the day and the mean score was calculated. And (4) deleting the maximum value and the minimum value of all the data, and then carrying out mean value calculation. Sebum, moisture, skin water loss (TEWL) tests were performed before the cheek and the forearm was tested for moisture and TEWL.
Preparing an instrument: skin oil, moisture, pH tester (Courage Khazaka, germany), skin moisture loss (TEWL) tester Tewameter TM300 (Courage Khazaka, germany). The test conditions were 22-24 ℃,40-60% RH. The sebum content and the water content were measured using a skin oil, moisture, and pH tester (test was performed, TEWL was performed using a skin Water loss (TEWL) tester, tewameter TM 300.
The experimental results are as follows: skin barrier repair enhancement effect the results of the experiment are recorded in table 4.
Table 4 skin barrier repair enhancement effect experimental results record
Figure BDA0002516438360000111
And (3) data analysis: from the data in the table, it can be seen that the children used the examples, the sebum content increased, and the sebum content and the moisture content tended to be balanced, while the TEWL was reduced. The comparative examples had little effect and were all within the floating range of values. The rising of the sebum content and the tendency of water and oil to balance are both the manifestations of skin barrier repair and enhancement, and the embodiment has good effect of repairing and enhancing the skin barrier.
Comparative example, example 10, which has the best skin barrier repair and enhancement ability, is followed by example 9, examples 7-8, examples 5-6, and examples 1-4 in that order. The increase in sebum content, which reflects on the one hand the repair or thickening of the sebum layer, combined with the water content, which appears to be data for substantially balancing the water content and the sebum content to approximately 3 times, provides a good skin barrier while reducing the skin water loss (TEWL). Example 10 combines the preferred ranges of group F material, allantoin, and group D material to provide excellent skin barrier repair and enhancement.
In the comparative examples, there was little effect on the sebum content and the water-oil balance, and only a maintenance effect was obtained. It is demonstrated that the combination of group F material, allantoin and group D material can act to repair and enhance the skin barrier.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.

Claims (3)

1. The mild washing and nursing product for the infants is characterized by comprising the following components in percentage by weight:
group A:
1-15% of glycerol;
1-10% C12-14 hydroxyalkyl hydroxyethyl sarcosine;
1-10% of sodium laureth-4 carboxylate;
1-10% of cocoyl amphodiacetate disodium;
group B:
1.1 to 25 percent of surfactant;
0.1-1% of EDTA disodium;
0.1-1% of allantoin;
group C:
1-3% of a thickening agent;
group D:
0.1-5% of a first skin feel modifier;
0.1-1% of a second skin feel modifier;
0.1 to 1 percent of polyquaternium;
group E:
0.01 to 0.1 percent of pH regulator;
and F group:
0.21 to 6.1 percent of skin conditioner;
0.01 to 0.3 percent of water polyaminopropyl biguanide;
inulin 0.08-0.7%;
0.02-0.3% of fructo-oligosaccharide;
pseudoalteromonas ferment product extract 0.1-5%;
lactobacillus fermentation lysate 0.1-5%;
the balance of water;
the skin conditioner comprises a first mixture comprising from about 0.01% to about 0.1% by weight of the total personal care product, from about 0.05% to about 0.5% by weight of the total personal care product, and a third mixture comprising from about 65% to about 82% by weight of sunflower seed oil and the balance of opuntia ficus indica fruit extract; the second mixture comprises 30-50% of flos Matricariae Chamomillae extract and the balance of water; the third mixture comprises 5-12% butanediol, 50-70% Citrus junos fruit extract and balance water;
the skin conditioner consists of a first mixture accounting for 0.01 to 0.1 percent of the total amount of the washing care product, a second mixture accounting for 0.05 to 0.5 percent of the total amount of the washing care product, a fourth mixture accounting for 0.05 to 0.5 percent of the total amount of the washing care product and the balance of a third mixture; the fourth mixture consists of 5 to 10 percent of butanediol, 25 to 45 percent of white-flower spring yellow chrysanthemum and the balance of water;
the second skin feel modifier consists of 45-65% of avocado oil PEG-11 esters and the balance of water;
the first skin feel modifier consists of 35-50% of glycosyl trehalose, 12-25% of hydrogenated starch hydrolysate and the balance of water; the mass part ratio of the first skin-feel modifier to the second skin-feel modifier to the polyquaternium-52 is 4;
the surfactant in the B group consists of decyl glucoside accounting for 1-10% of the total weight of the washing and care product, cocamidopropyl betaine accounting for 1-10% of the total weight of the washing and care product and poloxamer 184 accounting for the rest;
the thickening agent is PEG-120 methyl glucose dioleate.
2. The mild infant care product according to claim 1, wherein the weight ratio of the first mixture to the second mixture to the fourth mixture to the third mixture is (0.2-0.5): 1.
3. A process for the preparation of a mild toiletry for infants and young children according to claims 1-2, comprising the steps of:
s1: mixing water and group A raw materials uniformly for later use;
s2: adding the raw materials of the group B into the mixture obtained in the step S1, heating to 70-80 ℃, and uniformly stirring;
s3: adding the raw materials in the group C into the mixture obtained in the step S2, preserving heat and uniformly stirring;
s4: cooling to 55-60 ℃, adding the raw materials in the group D into the mixture obtained in the step S3, preserving heat and uniformly stirring;
s5: cooling to 40-50 ℃, adding a pH regulator into the mixture obtained in the step S4, preserving heat and uniformly stirring;
s6: adding the F group raw materials into the mixture obtained in the step S5, preserving heat and uniformly stirring;
s7: and (4) cooling the mixture obtained in the step (S6) to 35 +/-2 ℃, sieving the mixture by using a sieve of 80-100 meshes, discharging and filling.
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