CN108078828B

CN108078828B - Baby cream and preparation process thereof

Info

Publication number: CN108078828B
Application number: CN201711498724.3A
Authority: CN
Inventors: 郑民
Original assignee: Xiamen Jiabaolai Cosmetics Co ltd
Current assignee: Xiamen Jiabaolai Cosmetics Co ltd
Priority date: 2017-12-29
Filing date: 2017-12-29
Publication date: 2021-07-30
Anticipated expiration: 2037-12-29
Also published as: CN108078828A

Abstract

The invention discloses a baby cream and a preparation process thereof, wherein the baby cream comprises the following components: phase A materials (water, first humectant, natural plant antiseptic, first thickener, disodium ethylenediamine acetate, and allantoin); b phase materials (emollient oil mixture, emulsifier, tocopherol acetate); phase C materials (second thickener, second humectant); the first humectant comprises at least one of glycerol, 1, 2-pentanediol and sodium hyaluronate; the second humectant comprises at least two of Haematococcus extract, brown algae extract, and sorbitol; the natural plant preservative comprises at least two of a sargassum blunt extract, an enteromorpha oblata extract and a lactobacillus/algae extract fermentation product; the emollient oil mixture comprises at least two of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazil nut oil and rosewood seed oil. The baby cream has the advantages of high safety, mildness, no irritation, long-acting moisture retention and good anti-chapping effect.

Description

Baby cream and preparation process thereof

Technical Field

The invention relates to the technical field of baby skin care products, in particular to baby cream and a preparation process thereof.

Background

The skin of the infant is only one tenth of the skin of the adult, the horny layer is not mature, the dermis and the fibrous tissue are thin, the epidermis of the infant is a single layer of cells, the pigment layer of the skin is single and thin, the infant is very tender and sensitive, the capability of resisting a dry environment is weak, and particularly, the skin of the infant is easily damaged when the infant is dry in weather, so that the skin of the infant is reddened, rough, cracked and even bleeded and scabbed. In addition, the infant starts outdoor activities gradually, the skin is easily penetrated by external irritants or toxic substances, and the skin is damaged by friction, namely various skin problems of the infant at the stage are easy to come into the infant while being deficient.

Chinese patent with application publication No. CN105411987A and application publication date of 2015, 12 and 30 discloses a silk peptide moisturizing skin care product suitable for infants, and the components of the silk peptide moisturizing skin care product comprise, by weight: 5-10 parts of silk peptide, 3-8 parts of lanolin, 2-6 parts of honey extract, 5-7 parts of silk peptide surfactant, 1-5 parts of green preservative, 4-9 parts of liposome, 2-4 parts of citric acid and 30-50 parts of distilled water.

Although the prior art has good moisturizing effect, the lanolin contained in the lanolin is animal lipid extracted from wool, has moisturizing effect on skin and strong adhesiveness, but is oily in texture, and infants with sensitive skin can generate allergic phenomenon to lanolin products to cause skin redness and swelling. The existing skin care products for infants are mainly concentrated on moistening and nourishing, and few skin care products for relieving allergy and resisting allergy are available.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide baby cream which has the advantages of high safety and good moisturizing and anti-chapping effects.

In order to achieve the first purpose, the invention provides the following technical scheme:

the baby cream comprises the following components in parts by weight:

a phase material:

65-80 parts of water;

1.11-10.6 parts of a first humectant;

1-3 parts of a natural plant preservative;

0.1-0.5 part of first thickening agent;

0.01-0.1 part of disodium ethylenediamine acetate;

0.1-0.5 part of allantoin;

b, phase material:

4.2-22.5 parts of emollient oil mixture;

2-8 parts of an emulsifier;

0.1-1 part of tocopherol acetate;

c phase material:

0.1-1 part of a second thickening agent;

0.1-1 part of a second humectant;

the first humectant comprises at least one of glycerol, 1, 2-pentanediol and sodium hyaluronate;

the second humectant comprises at least two of Haematococcus extract, brown algae extract, and sorbitol;

the natural plant preservative comprises at least two of a sargassum blunt extract, an enteromorpha oblata extract and a lactobacillus/algae extract fermentation product;

the skin caring oil mixture comprises at least two of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazilian fruit seed oil and rosewood seed oil.

Through the technical scheme, in the phase A material and the first moisturizing agent, the glycerol belongs to a micromolecule moisturizing component, the touch feeling is soft, and the moisturizing effect is obvious. The 1, 2-pentanediol belongs to a micromolecular humectant, and has good lubricating effect and bacteriostatic effect. The sodium hyaluronate has strong moisturizing effect, can absorb 1000 times of water by weight of the sodium hyaluronate, and is easily absorbed by the skin of a baby with more water content, so that the skin of the baby is more moisturized.

In the natural plant preservatives, the gulfweed extract, the Enteromorpha compressa extract and the lactobacillus/algae extract fermentation products have excellent preservative effect, so that bacteria (including staphylococcus aureus, escherichia coli and pseudomonas aeruginosa) and mould yeasts (including aspergillus niger and candida albicans) are not easy to generate in the baby cream, and the shelf life of the baby cream is prolonged. And the gulfweed extract, the Enteromorpha compressa extract and the lactobacillus/algae extract fermentation products are mild and non-irritating to the skin, light and thin in texture, not easy to damage the tender skin of the infant, have a protective effect on the skin of the infant and not easy to cause bacteria in the environment to damage the skin of the infant. In addition, the gulfweed extract and the Enteromorpha compressa extract are obtained by adopting an extraction mode, are natural and have high safety coefficient.

The extraction modes of the gulfweed extract and the Enteromorpha compressa extract are as follows:

step one, ultrasonic cleaning and drying gulfweed and Enteromorpha compressa respectively to obtain clean raw materials;

step two, the clean raw material obtained in the step one is processed by supercritical CO₂Extracting at 28-35 deg.C under 16-19MPa for 1-1.5h，CO₂The flow rate is 18-20kg/h to obtain an extracting solution;

and step three, distilling the extracting solution obtained in the step, wherein the absolute pressure of distillation is 4-5MPa, the rotating speed is 200-230rpm, and the flow rate is 2.3-2.5mL/min, so as to obtain the gulfweed extract or the Enteromorpha compressa extract.

The disodium ethylenediamine acetate has a good chelating effect, and is beneficial to coating trace elements remained in the components after being matched with other components in the application, so that the possibility of deterioration is reduced. The allantoin is natural and mild, has good functions of resisting inflammation, relieving and helping skin tissue regeneration, and has good protective effect on skin.

In the B phase material, the tocopherol acetate has a good moisturizing effect and good grease oxidation resistance, protects the skin from being damaged by ultraviolet rays, and can soften the skin and keep moisture. Hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, brazil nut oil and rosewood seed oil in the skin-moistening oil mixture have good moistening effect, and the possibility of skin chapping of infants is reduced. The hydrogenated polydecene has good compatibility with other components in the phase A material, the phase B material and the phase C material, so that good dispersibility is achieved. The caprylic/capric triglyceride has low viscosity, and is not easy to agglomerate with other components in the phase A material, the phase B material and the phase C material, thereby achieving good dispersion effect and water-resistant effect. Squalane has good lubricating effect and low condensation point, can be used in cold weather, and can fully moisten tender skin of infants. The polydimethylsiloxane has a hydrophobic effect, is relatively smooth in texture, is fresh and not sticky, is beneficial to enabling the baby cream to have a smooth texture, and after the baby cream is smeared on the skin of a baby, a thin protective layer is formed on the surface of the skin, but the restraint feeling of the skin of the baby is not easy to occur. The Brazil nut seed oil and the rosewood seed oil both have mild softening effect and are not easy to cause stimulation to the tender skin of the infant.

The preparation method of the brazil nut seed oil and the rosewood seed oil comprises the following steps:

step A, taking Brazil fruit seeds and rosewood seeds respectively, adding an ethanol water solution, performing heat preservation and ultrasonic extraction for 0.5-2h at the temperature of 5-30 ℃, leaching for 2-3 times, combining leaching solutions, filtering, and performing heat preservation and concentration at the temperature of 5-30 ℃ to obtain an ethanol extract; adding water into the concentrated alcohol extract, extracting, and volatilizing the dry solvent at 5-30 deg.C to obtain Brazilian fruit seed oil and rosewood seed oil respectively.

Through researches (test one, test two and test four), the first moisturizing agent, the second moisturizing agent, the natural plant preservative and the moisturizing grease mixture form a compound effect mutually, so that the formed baby cream is slightly sticky, has smooth texture, is mild and non-irritant, is beneficial to absorption of young and tender baby skin, and has excellent moisturizing and anti-chapping effects; in addition, researches (experiment three) show that the baby cream has a safe and effective antiseptic effect, and bacteria (including staphylococcus aureus, escherichia coli and pseudomonas aeruginosa) and mycete yeasts (including aspergillus niger and candida albicans) in the baby cream are not easy to generate; after the baby cream is smeared on the skin of a baby, a protective layer can be formed on the surface of the skin, and the infringement of bacteria or mould yeasts in the external environment on the skin of the baby is reduced.

The research (test one) finds that the mutual cooperation of the disodium ethylenediamine acetate, the allantoin and the emulsifier is beneficial to enabling the baby cream to have uniform, stable and fine sticky feeling, the phenomenon of caking or agglomeration is not easy to occur, and the overall texture of the baby cream is smooth. When the baby cream is uniformly smeared on the surface of the skin of a baby, a protective layer can be formed, and the baby cream has a soothing effect on the skin.

More preferably: the baby cream comprises the following components in parts by weight:

a phase material:

65-75 parts of water;

5.23-10.6 parts of a first humectant;

1-2 parts of a natural plant preservative;

0.1-0.3 part of first thickening agent;

0.01-0.05 part of disodium ethylenediamine acetate;

0.1-0.3 part of allantoin;

b, phase material:

10.3-22.5 parts of emollient oil mixture;

2-6 parts of an emulsifier;

0.1-0.5 part of tocopherol acetate;

c phase material:

0.5-1 part of a second thickening agent;

0.5-1 part of second humectant.

Through the technical scheme, researches (test I and test II) find that the components in the weight part range are matched with each other, so that better effects of moisturizing, moistening and preventing chapping can be achieved.

More preferably: in the phase A material, the first humectant consists of glycerol, 1, 2-pentanediol and sodium hyaluronate in the weight portion ratio of 150-160:3-4: 1.

Through the technical scheme, researches (test I, test II and test III) show that the effect that the baby cream is easily absorbed by the skin of a baby and the moisturizing effect on the skin of the baby can be further improved by matching the glycerin, the 1, 2-pentanediol and the sodium hyaluronate in the weight part range.

The baby cream as claimed in claim 1 or 2, wherein in the phase B material, the emollient oil mixture is composed of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, brazil nut oil and rosewood seed oil in a weight ratio of 25:15-15.8: 10-11: 7.5:2-2.5: 1.

Through the technical scheme, researches (test one and test two) find that the hydrogenated polydecene, the caprylic/capric triglyceride, the squalane, the polydimethylsiloxane, the brazil fruit seed oil and the rosewood seed oil in the weight part range form a compounding effect, so that the moisturizing effect of the baby cream on the skin of a baby is improved, the phenomenon of skin chapping of the baby is relieved more effectively, and the possibility of skin chapping of the baby can be prevented more effectively.

More preferably: in the phase A material, the first thickening agent is acryloyl dimethyl ammonium taurate/VP copolymer.

Through the technical scheme, the acryloyl dimethyl ammonium taurate/VP copolymer has good hydrophilicity and viscosity increasing property, is wide in applicable pH value range, can show good thickening effect in an environment with the pH value of 4-9, and is beneficial to improving the viscous texture of the phase A material.

More preferably: in the phase B material, the emulsifier comprises at least one of cetearyl glucoside, cetearyl alcohol cornstalk glycoside and cetearyl alcohol.

Through the technical scheme, the cetearyl glucoside has good emulsifying effect and low viscosity, and is beneficial to increasing the moisturizing effect. Cetearyl alcohol wheat straw glycosides have excellent mild and non-irritating emulsification properties. Cetearyl alcohol has good hydrophilicity and emulsifying effect. Namely, the emulsifier formed by at least one of cetearyl glucoside, cetearyl cornstalk glycoside and cetearyl alcohol is beneficial to fully emulsifying the baby cream in the application, improving the overall texture of the baby cream, enabling the baby cream to have moderate viscous feeling and fine touch feeling, and being easier to be absorbed by the tender skin of a baby.

More preferably: in the C-phase material, the second thickening agent is composed of sodium polyacrylate, mineral oil and laureth-6.

Through the technical scheme, researches (test I and test II) find that the C-phase material consisting of the sodium polyacrylate, the mineral oil and the laureth-6 has a better viscous effect, does not easily cause the baby cream to be over-thin and to flow randomly, and does not easily cause the baby cream to be over-viscous to cause the baby cream to be difficult to be smeared uniformly in the using process.

More preferably: the baby cream also comprises 0.01-0.1 part by weight of essence.

Through the technical scheme, the baby cream has the advantages that the pleasant fragrance of the baby cream is increased, the baby can accept the baby cream more easily, and the love degree of the baby cream is increased.

The second purpose of the invention is to provide a preparation process of the baby cream.

In order to achieve the second purpose, the invention provides the following technical scheme:

a preparation process of baby cream comprises the following steps:

s1, fully mixing water, a first moisturizing agent, a natural plant preservative, a first thickening agent, ethylene diamine acetate disodium and allantoin in corresponding parts by weight at the temperature of 80-85 ℃ to form a phase A material;

s2, fully mixing the emollient oil mixture and the emulsifier in corresponding parts by weight at the temperature of 80-85 ℃ to form a phase B material;

s3, adding the phase B material obtained in the step S2 into the phase A material obtained in the step S1, uniformly mixing, and cooling to 55-60 ℃ to obtain a first mixture;

s4, fully mixing the second thickening agent and the second humectant in corresponding parts by weight to form a phase C material;

s5, fully mixing the C phase material obtained in the step S4 and the first mixture obtained in the step S3, and cooling to 40-45 ℃ to obtain the baby cream with the pH value of 5.8-6.5.

Through the technical scheme, as the components in the phase A material are easy to dissolve in water, the phase B material contains the skin moistening oil mixture, and the temperature of the phase A material and the temperature of the phase B material are both within the range of 80-85 ℃, the phase A material and the phase B material are more uniformly mixed, and the phenomenon of agglomeration or agglomeration in the phase A material and the phase B material is not easy to occur. In step S4, the second thickener and the second humectant are mixed separately, which also contributes to improving the mixing sufficiency of the phase C material.

In the step S3, the phase B material is added into the phase A material, the mixture is homogenized for 10 minutes at the rotating speed of 4000r/min, the phase B material and the phase A material are fully mixed, then the mixture is cooled to 55-60 ℃, and the phase C material formed by the second thickening agent and the second humectant is added, so that the phase C material can be well kept, and the mixing uniformity among the phase C material, the phase A material and the phase B material can be improved. The formed baby cream has the pH value within the range of 5.8-6.5, is mild, and is not easy to cause irritation and damage to the tender skin of the baby.

More preferably: in the step S5, after cooling to 40-45 ℃, 0.01-0.1 part by weight of essence is added and mixed evenly.

Through the technical scheme, the essence, the C phase material and the first mixture are uniformly mixed, so that the obtained baby cream has more pleasant smell and is easily accepted and loved by babies. And in the environment of 40-45 ℃, the essence can be helpful to retain the smell of the essence to a greater extent.

In conclusion, the invention has the following beneficial effects:

1. the first humectant, the second humectant, the natural plant preservative and the moisturizing oil mixture form a compounding effect mutually, so that the formed baby cream has the effects of being slightly viscous but having more smooth texture, is beneficial to absorption of young baby skin, and has excellent moisturizing and anti-chapping effects; after the baby cream is smeared on the skin of a baby, a protective layer can be formed on the surface of the skin, and long-acting water locking is realized, so that the infringement of bacteria or mould yeasts in the external environment on the skin of the baby is reduced;

2. the disodium ethylenediamine acetate, the allantoin and the emulsifier are mutually matched, so that the baby cream has uniform, stable and fine sticky feeling, the phenomenon of caking or agglomeration is not easy to occur, the overall texture of the baby cream is smooth, and when the baby cream is uniformly smeared on the surface of the skin of a baby, a protective layer can be formed to play a role in relieving the skin, so that the skin of the baby is moist and elastic;

3. the natural plant preservative has a safe and effective preservative effect, and is not easy to generate bacteria (including staphylococcus aureus, escherichia coli and pseudomonas aeruginosa) and mould yeasts (including aspergillus niger and candida albicans) in the baby cream;

4. the adopted raw materials are mild, the stimulation effect on the tender skin of the baby can be reduced, and the skin is not easy to be allergic.

Detailed Description

The present invention will be described in detail with reference to examples.

Example 1: an infant cream comprises the components and corresponding parts by weight shown in table 1, and is prepared by the following steps:

s1, fully mixing water, a first humectant, a natural plant preservative, a first thickener, disodium ethylenediamine acetate and allantoin at the temperature of 80 ℃ to form a phase A material;

s2, fully mixing the skin-moistening oil mixture and the emulsifier at the temperature of 80 ℃ to form a B-phase material;

s3, adding the phase B material obtained in the step S2 into the phase A material obtained in the step S1, homogenizing at the rotating speed of 4000rpm for 10min, starting a cold water bath, continuing homogenizing for 10min, uniformly mixing, and cooling to 60 ℃ to obtain a first mixture;

s4, homogenizing the second thickening agent and the second humectant at the rotation speed of 4000rpm for 10min, and fully mixing to form a C-phase material;

s5, homogenizing the C phase material obtained in the step S4 and the first mixture obtained in the step S3 at the rotation speed of 4000rpm for 10min, and cooling to 45 ℃ after complete dissolution to obtain the baby cream.

Wherein, in the phase A material, the first humectant consists of glycerol, 1, 2-pentanediol and sodium hyaluronate with the weight portion ratio of 150: 3: 1; the first thickening agent is acryloyl dimethyl ammonium taurate/VP copolymer; the natural plant preservative consists of a gulfweed extract, an Enteromorpha compressa extract and a lactobacillus/algae extract fermentation product with the weight part ratio of 1: 1.

In the phase B material, the skin moistening oil mixture consists of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazil nut oil and rosewood seed oil in the weight portion ratio of 25: 15.8: 11: 7.5: 2: 1; the emulsifier comprises cetearyl glucoside, cetearyl alcohol cornstalk glycoside and cetearyl alcohol in a weight part ratio of 3: 1.

In the phase C material, the second thickening agent consists of sodium polyacrylate, mineral oil and laureth-6 with the weight portion ratio of 1.5: 1: 1.2; the second humectant comprises Haematococcus extract, brown algae extract, and sorbitol at weight ratio of 1: 3.5.

Examples 2 to 8: the difference between the baby cream and the baby cream in the embodiment 1 is that the components and the corresponding parts by weight are shown in the table 1, and in the step S5, after the baby cream is cooled to 45 ℃, essence is added, and the baby cream is homogenized at the rotating speed of 3000r/min to obtain the baby cream.

TABLE 1 Components included in examples 1-8 and their corresponding parts by weight

Example 9: an infant cream differs from example 2 in that a first moisturizing agent is composed of glycerin, 1, 2-pentanediol, and sodium hyaluronate in a weight ratio of 160: 4:1, and 0.1 part of citric acid is added to adjust the pH in step S5.

Example 10: an infant cream differs from example 2 in that the first humectant consists of glycerin, 1, 2-pentanediol, and sodium hyaluronate in a ratio of 155: 3: 1 parts by weight.

Example 11: an infant cream differs from example 2 in that the first humectant consists of glycerin, 1, 2-pentanediol in a weight ratio of 50: 1.

Example 12: an infant cream differs from example 2 in that the first humectant consists of glycerin and sodium hyaluronate in a weight ratio of 160: 1.

Example 13: an infant cream differs from example 2 in that the first humectant consists of 1, 2-pentanediol and sodium hyaluronate in a weight ratio of 3: 1.

Example 14: an infant cream is different from the infant cream in example 9 in that in the phase C material, the second humectant is composed of an extract of Haematococcus and an extract of brown algae in a weight ratio of 1: 1.

Example 15: an infant cream is different from the infant cream in example 9 in that in the phase C material, the second humectant consists of extract of Haematococcus and sorbitol in a weight ratio of 1: 3.5.

Example 16: an infant cream is different from that in example 9 in that in the phase C material, the second humectant consists of brown algae extract and sorbitol in a weight ratio of 1: 3.5.

Example 17: an infant cream differs from that of example 9 in that in phase B, the emollient oil mixture consists of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazilian fruit seed oil and rosewood seed oil in a weight ratio of 25: 15: 10: 7.5: 2.5:1, and 0.08 part of citric acid is added to adjust the pH in step S5.

Example 18: an infant cream differs from that in example 9 in that in the phase B, the emollient oil mixture consists of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazilian fruit seed oil and rosewood seed oil in a weight ratio of 25: 15: 10.5: 7.5: 2: 1.

Example 19: an infant cream differs from that in example 9 in that in phase B, the emollient oil mixture consists of hydrogenated polydecene and caprylic/capric triglyceride in a weight ratio of 25: 15.

Example 20: an infant cream is different from that in example 9 in that in the phase B material, the skin moistening oil mixture consists of squalane, polydimethylsiloxane, Brazil nut oil and rosewood seed oil in the weight portion ratio of 10: 7.5: 2.5: 1.

Example 21: an infant cream is different from the infant cream in example 9 in that in the phase A material, the natural plant preservative comprises a gulfweed extract and an Enteromorpha compressa extract in a weight ratio of 1: 1.

Example 22: an infant cream differs from that of example 9 in that in phase A, the natural plant preservative is composed of a sargassum blunt extract and a lactobacillus/algae extract fermentation product in a weight ratio of 1: 1.

Example 23: an infant cream differs from the cream of example 9 in that the natural plant preservative in the phase a material consists of enteromorpha oblata extract and lactobacillus/algae extract fermentation product in a weight ratio of 1: 1.

Example 24: an infant cream differs from example 2 in that in phase B the emulsifier is cetearyl glucoside.

Example 25: an infant cream differs from that of example 2 in that in phase B, the emulsifier is cetearyl alcohol wheat straw glycoside.

Example 26: an infant cream differs from example 2 in that in phase B, the emulsifier is cetearyl alcohol.

Example 27: an infant cream is different from the cream in example 2 in that in the phase B material, the emulsifier is cetearyl glucoside and cetearyl alcohol wheat straw glycoside with the weight part of 3: 1.

Example 28: an infant cream, which is different from example 2 in that, in the preparation process, the temperatures in step S1 and step S2 are set to 85 ℃; in step S3, cooling to 55 ℃; in step S5, the temperature is cooled to 40 ℃.

Comparative example 1: an infant cream, which is different from that of example 2 in that, as disclosed in chinese patent with application publication No. CN105411987A and application publication date 2015, 12 and 30, the preparation process comprises:

(1) dissolving the degummed silk in an enzyme solution, carrying out low-temperature enzymolysis, dialyzing, concentrating and filtering to obtain a silk peptide solution with the mass fraction of 5%, wherein the molecular weight of the silk peptide is 500-3000Da, and the part of 100-2000Da accounts for 55% of all the silk peptides, and then freeze-drying the silk peptide solution to obtain the high-purity silk peptide powder with the impurity ion content of less than 1%.

(2) Grinding and grinding 5 parts by weight of high-purity silk peptide powder, adding 30 parts by weight of distilled water, stirring for 5min, heating, keeping the temperature after heating to 50 ℃, adding 3 parts by weight of lanolin, 2 parts by weight of honey extract, 5 parts by weight of fatty-amino acid silk peptide surfactant, 1 part by weight of chitosan and tea polyphenol green preservative and 4 parts by weight of liposome, fully stirring until the mixture is uniformly mixed, adding 2 parts by weight of citric acid to adjust the pH value to 6.5, continuing stirring, returning to the room temperature, and carrying out vacuum defoamation to obtain the silk peptide moisturizing skin care product suitable for infants.

Comparative examples 2 to 6: an infant cream differs from example 2 in that the components and their respective parts by weight are as shown in table 2.

TABLE 2 Included components of comparative examples 2-6 and their corresponding parts by weight

Comparative examples 7 to 10: an infant cream differs from example 2 in that the components and their respective parts by weight are included as shown in table 3.

TABLE 3 Components included in comparative examples 7-10 and their corresponding parts by weight

Comparative examples 11 to 14: an infant cream differs from example 2 in that the components and their respective parts by weight are included as shown in table 4.

TABLE 4 Components and their respective parts by weight encompassed by comparative examples 11-14

Comparative example 15: an infant cream differs from example 2 in that the natural plant preservative is replaced by 0.03 parts by weight of DMDM hydantoin, 0.05 parts by weight of iodopropynyl butylcarbamate, 0.06 parts by weight of methylisothiazolinone, and 0.02 parts by weight of butanediol.

Comparative example 16: an infant cream differs from example 2 in that lanolin is used instead of the emollient oil mixture.

Comparative example 17: a baby cream, which is different from the baby cream in example 2, in the preparation process, water, a first moisturizing agent, a natural plant preservative, a first thickening agent, disodium ethylenediamine acetate, allantoin, a skin oil mixture, an emulsifier, tocopherol acetate, a second thickening agent, a second moisturizing agent and essence are mixed together at 4000rpm for 30min to obtain the baby cream.

Test one: appearance, texture, pH measurement test

Test samples: the baby creams obtained in examples 1 to 28 were selected as test sample groups 1 to 28, each having three identical and corresponding test samples, and the baby creams obtained in comparative examples 1 to 17 were selected as control sample groups 1 to 17, each having three identical and corresponding control samples.

The test method comprises the following steps:

1. observing the appearance and the texture of the test sample groups 1-28 and the control sample groups 1-17, and recording;

2. and respectively detecting the pH values of the test samples in the test sample groups 1-28, the control sample group 1, the control samples in the control samples 11-14 and the control samples in the control samples 16-17 by using a pH detector, and after average treatment, marking as the pH values of the test sample groups 1-28, the control sample groups 1, 11-14 and 16-17.

And (3) test results: the appearance, texture and pH of the test sample groups 1 to 28 and the control sample groups 1, 11 to 14 and 16 to 17 are shown in Table 5.

TABLE 5 appearance, texture, pH of test sample groups 1-28, control sample groups 1, 11-14, 16-17

As can be seen from Table 5, the test specimens 1-28 had uniform appearance, no lumps, soft and smooth texture, and good texture; in addition, the p value of the test sample 1-28 is between 5.8-6.5, is weakly acidic, is milder, and is not easy to damage the tender skin of the infant. Although the appearance and pH of control 1 did not differ much from those of test samples 1-28, it was slightly sticky, not smooth enough, and had other problems, as will be described in the following tests. The controls 11-14 and 16-17 had different degrees of caking and agglomeration and had a non-smooth texture. The reason for the above difference is that: the first humectant, the second humectant, the natural plant preservative and the skin moistening oil mixture form a compounding effect mutually, so that the formed baby cream has the effects of being slightly sticky and having smoother texture. And the disodium ethylenediamine acetate, the allantoin and the emulsifier are mutually matched, so that the baby cream has uniform, stable and fine sticky feeling, the phenomenon of caking or agglomeration is not easy to occur, and the overall texture of the baby cream is smooth. And lanolin is adopted to replace a skin moistening grease mixture, so that the phenomenon of conglobation caused by overhigh viscosity is easily caused.

And (2) test II: test of absorption and moisture retention

Test samples: the baby creams obtained in examples 1 to 28 were selected as test samples 1 to 28, and the baby creams obtained in comparative examples 1 to 10, comparative example 15 and comparative example 17 were selected as controls 1 to 10, 15 and 17.

The test method comprises the following steps: 400 infants in the same area and born for 365 days are selected and evenly divided into 40 groups of 10 infants. The measuring area mark is made on the inner side of the forearm of each tested baby, and the area of the test area is 3cm multiplied by 3 cm. Skin moisture detection was performed on the test area in advance using a capacitance-method skin moisture meter as an initial skin moisture content value. (No feeding during the test period)

Test samples 1-28 and controls 1-10, 15, 17 were applied uniformly in a single application at (2.0 + -0.1) mg/cm2 for 15s, and the area was gently wiped with a heart-print facial tissue to see if complete absorption had occurred.

After the samples were completely absorbed, respectively, the skin moisture content of the test area was measured as a first skin moisture content value (the absorption at this time was taken as a first moisture retention rate, in terms of 100%);

after 1h, detecting the skin moisture content of the test area as a second skin moisture content value, and calculating a second moisture retention rate at the moment by using the absorption rate of 100%;

after 2h, detecting the skin moisture content of the test area as a third skin moisture content value, and calculating a third moisture retention rate at the moment by using the absorption rate of 100%;

and respectively carrying out average treatment on the first moisture retention rate, the second moisture retention rate and the third moisture retention rate of each group, and recording and analyzing.

And (3) test results: the absorption and moisture retention rates of test samples 1 to 28, control samples 1 to 10, control sample 15 and control sample 17 are shown in Table 6.

TABLE 6 absorption and moisture retention rates of test samples 1-28, control samples 1-10, control sample 15, and control sample 17

As can be seen from table 6, the test samples 1 to 28 were completely absorbed by the skin of the infant within 15s after being uniformly applied, and the second moisture retention rate and the third moisture retention rate were both high within 2h after complete absorption, indicating that a good moisture retention effect was achieved within 2 h. Comparative sample 1 can maintain a slightly high moisture retention rate within 1 hour after complete absorption, but after 2 hours, the third moisture retention rate was low, indicating that the time period for moisture retention was not long; furthermore, it is difficult for the skin of the infant to absorb it sufficiently within 15 s. The control samples 2-10, 15 and 17 cannot be completely absorbed by the skin of the infant within 15s after being uniformly smeared, and the second moisturizing rate and the third moisturizing rate are lower, which indicates that the control samples 2-10 have poor moisturizing effect and are difficult to moisturize the skin of the infant for a long time. The main reasons for the above differences are: the first humectant, the second humectant, the natural plant preservative and the skin moistening oil mixture form a compounding effect mutually, so that the skin of a young and tender infant can be absorbed favorably, a protective layer is formed on the surface of the skin, excellent moisturizing and anti-chapping effects are achieved, and long-acting water locking can be achieved.

And (3) test III: test of anticorrosive effect

Test samples: the baby creams obtained in examples 1 to 28 were selected as test specimens 1 to 28, and the baby cream obtained in comparative example 15 was selected as control specimen 15.

The test method comprises the following steps:

1) reference is made to the United states pharmacopoeia USP- <51> Antiicrobial EFFECTIVENESS TESTING

2) And introducing a standard sample for test comparison. One bottle of the no-additive product 1 which is obtained from the market and is sold is taken to be used together with the test sample for corrosion prevention challenge so as to obtain more intuitive judgment.

Evaluation criteria:

1, original standard regulation:

after inoculation once for each gram of test sample 1-28 and control sample 15, the viable bacteria amount is reduced to not higher than 0.1% of the initial concentration on day 14, and then gradually reduced to 0 on day 28. Compliance with the standard is effective (pass) and non-compliance with ineffective (fail) preservation.

2 this laboratory specifies:

after one inoculation per gram of sample, the amount of viable bacteria on day 14 was zero and was available. Meanwhile, the bacteria are specified to be detected on the 7 th day, the survival amount is below 9.0 multiplied by 103CFU/g, the detection can be continued, and the excess is not detected. Meanwhile, the mold is detected on day 4, the viable bacteria amount is below 9.0 multiplied by 103CFU/g, the detection can be continued, the viable bacteria amount exceeds the undetected bacteria amount, and the standard is higher than the original standard.

Test strains:

bacteria: staphylococcus aureus, escherichia coli, pseudomonas aeruginosa;

and (3) mould yeast: aspergillus niger, candida albicans;

preparing a bacterial liquid for experiments:

before experiment, each strain is inoculated to the corresponding culture medium slant, and the bacteria are cultured for 48 hours in a constant temperature incubator at 36 +/-1 ℃. Culturing the mould yeast in a constant temperature incubator at 27 +/-1 ℃ for 120 hours. Then selecting a proper amount of bacterial colonies, uniformly mixing the bacterial colonies in sterile physiological saline to prepare a mixed bacterial suspension with the concentration of about 1.0 multiplied by 108CFU/ml and a mixed mould spore suspension with the concentration of about 1.0 multiplied by 107CFU/ml, and storing the mixed mould spore suspension at 4 ℃ for later use.

Testing:

the experimental method is formulated by referring to a method for detecting the effect of the preservative by a microbial 28-day challenge test on United states Pharmacopeia. Weighing 100g of each of the test samples 1-28 and the control sample 15, filling the test samples and the control sample into plastic bottles with the same numbers, and adding the bacteria in the same amount: 1: 1 mixed suspension of mould yeast. And (3) fully and uniformly mixing to ensure that the bacteria content of each gram of the detected sample is 9.0 multiplied by 106-1.0 multiplied by 104CFU/g, and respectively culturing the samples in a constant-temperature incubator at 36 +/-1 ℃. Samples were taken on days 3, 7, 14, and 21 of inoculation for bacterial load analysis. (original standard is 0 hours, 1 day, 3 days, 7 days, 14 days, 21 days and 28 days).

And fourthly, analyzing the bacterial quantity of the sample:

accurately weighing 5 g of sample, adding glass beads and 45ml of sterile water, fully shaking and uniformly mixing to prepare a diluent with the ratio of 1: 10, and sequentially diluting the diluent with the sterile water in a 10-time progressive mode. The bacteria content of the samples was counted by plate pour. The test method was performed according to the method provided in the cosmetic hygiene code.

And (3) test results: the total number of bacterial colonies for test samples 1-28, control sample 15 are shown in Table 7; the total number of fungal colonies for test samples 1-28 and control sample 15 are shown in Table 8.

TABLE 7 Total bacterial colony count for test samples 1-28, control sample 15

TABLE 8 Total fungal colony counts for test samples 1-28, control 15

As can be seen from Table 7, the bacteria content of the test samples 1-28 tended to decrease significantly when the culture was carried out for 3-7 days, but was less than 10CFU/g by 14 days, and was kept at 10CFU/g by 21 days, thus having a more stable antibacterial effect; while the control 15 had a slight decrease in the bacterial content between days 3 and 21, the bacterial content remained at 1.5X 10 after day 21²CFU/g, indicating that control 15 had poor antibacterial ability.

As can be seen from Table 8, the fungal content of the test samples 1-28 decreased to less than 10CFU/g by the day 7 of the culture, and remained at 10CFU/g by the day 21 of the culture, which resulted in a more stable antifungal effect; while the control 15 had a slight decrease in fungal content between days 3 and 21, the fungal content remained at 0.5X 10 after day 21²CFU/g, indicating that control 15 had poor antifungal capacity.

The reason for the above difference is that: the natural plant preservative has safe and effective preservative effect, and is not easy to generate bacteria (including staphylococcus aureus, escherichia coli and pseudomonas aeruginosa) and mould yeasts (including aspergillus niger and candida albicans) in the baby cream. When the preservative consisting of 0.03 parts by weight of DMDM hydantoin, 0.05 parts by weight of iodopropynyl butylcarbamate, 0.06 parts by weight of methylisothiazolinone and 0.02 parts by weight of butanediol is used, the effect of inhibiting and killing bacteria for a long time is difficult to achieve. Therefore, the test samples 1-28 have better protective effect after being applied to the skin of the infant, and can effectively resist the external bacteria, fungi or toxic substances from entering the skin, thereby reducing the possibility of skin problems of the infant at this stage.

And (4) testing: irritation test

Test samples: the baby creams obtained in examples 1 to 28 were selected as test samples 1 to 28, and the baby creams obtained in comparative examples 1 to 17 were selected as control samples 1 to 17.

The test method comprises the following steps: the test is carried out according to the regulation of 'cosmetic hygiene Specification (2007) edition', 10 healthy white guinea pigs are respectively selected for the test sample 1-28 and the control sample 1-17 in parallel, and the test temperature and humidity are 20-25 ℃/60-70 RH%; shearing off hairs on two sides of the spine of the test animal 24h before the test, wherein the hair removing ranges are respectively 2cm multiplied by 3cm, and the smearing area is 2.5cm multiplied by 2.5 cm; 0.1g of the test substance is directly applied to the skin, covered by oiled paper and two layers of gauze after being applied, fixed by using a non-irritant adhesive tape and applied for 24 hours. After the test, the residual test substance was removed with warm water. Skin reactions at the applied sites were observed 1, 24, 48 and 72 hours after removal of the test substances, skin reaction scores were made according to table 9, comprehensive evaluations were made with the mean value of the scores of the test animals, and skin irritation intensity was judged according to table 10 based on the highest mean value of the scores at each observation time point of 24, 48 and 72 hours. The control was obtained by covering the oiled paper with two layers of gauze and fixing the gauze with a non-irritating adhesive tape.

TABLE 9 reference Standard for skin irritation response scores

TABLE 10 reference standards for skin irritation intensity grading

Integral mean value	Intensity grading
		0-＜0.5	Has no irritation
0.5-＜2.0	Mild irritation
		2.0-＜6.0	Moderate irritation
6.0-＜8.0	Strong irritation

And (3) test results: the degree of skin acute irritation for test samples 1-28 is shown in Table 11; the degree of acute skin irritation for controls 1-17 is shown in Table 12.

TABLE 11 degree of skin acute irritation for test samples 1-28

Test specimen	No irritation (example)	Mild irritation (example)	Moderate irritation (example)	Strong irritation (example)
					Test sample 1	10	0	0	0
Test sample 2	10	0	0	0
					Test sample 3	10	0	0	0
Test sample 4	10	0	0	0
					Test sample 5	10	0	0	0
Test sample 6	10	0	0	0
					Test sample 7	10	0	0	0
Test specimen 8	10	0	0	0
					Test sample 9	10	0	0	0
Test specimen 10	10	0	0	0
					Test specimen 11	10	0	0	0
Test specimen 12	10	0	0	0
					Test specimen 13	10	0	0	0
Test specimen 14	10	0	0	0
					Test specimen 15	10	0	0	0
Test specimen 16	10	0	0	0
					Test specimen 17	10	0	0	0
Test specimen 18	10	0	0	0
					Test specimen 19	10	0	0	0
Test specimen 20	10	0	0	0
					Test specimen 21	10	0	0	0
Test specimen 22	10	0	0	0
					Test specimen 23	10	0	0	0
Test specimen 24	10	0	0	0
					Test specimen 25	10	0	0	0
Test specimen 26	10	0	0	0
					Test specimen 27	10	0	0	0
Test specimen 28	10	0	0	0

TABLE 12 degree of skin acute irritation for controls 1-17

Control sample	No irritation (example)	Mild irritation (example)	Moderate irritation (example)	Strong irritation (example)
					Control 1	8	2	0	0
Control 2	5	4	1	0
					Control 3	5	4	1	0
Control 4	5	4	1	0
					Control 5	6	3	1	0
Control 6	5	4	1	0
					Control 7	3	3	2	2
Control sample 8	4	4	1	1
					Control 9	4	5	1	0
Control sample 10	4	4	1	1
					Control sample 11	9	1	0	0
Control sample 12	9	1	0	0
					Control 13	9	1	0	0
Control sample 14	9	1	0	0
					Control sample 15	5	3	1	1
Control sample 16	3	5	1	1
					Control sample 17	8	1	1	0

As is clear from table 11, the test samples 1 to 28 showed very little irritation and almost no irritation to the skin of white guinea pigs. As can be seen from Table 12, control 1, control 11-14 and control 17 are less irritating to the skin of white guinea pigs, but also contain varying degrees of mild irritation, even moderate irritation. The comparison samples 2-6 have a large degree of mild irritation to the skin of white guinea pigs, and also have moderate irritation; controls 7-10 were more irritating to white guinea pig skin with a lesser proportion of non-irritants, and the proportion of moderate or even strong irritants was further increased. The above differences illustrate that: the natural plant preservative has high safety factor, is not irritant and has better protective effect on the skin of the infant. And the first humectant, the second humectant, the natural plant preservative and the skin moistening oil mixture are matched with each other, and the disodium ethylenediamine acetate, the allantoin and the emulsifier are matched with each other, so that the irritation to the white guinea pig skin is greatly reduced, and the skin moisturizing cream is also suitable for the tender skin of infants and almost has no irritation.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. The infant cream is characterized by comprising the following components in parts by weight:

a phase material:

65-80 parts of water;

1.11-10.6 parts of a first humectant;

1-3 parts of a natural plant preservative;

0.1-0.5 part of first thickening agent;

0.01-0.1 part of disodium ethylene diamine tetraacetate;

0.1-0.5 part of allantoin;

b, phase material:

4.2-22.5 parts of emollient oil mixture;

2-8 parts of an emulsifier;

0.1-1 part of tocopherol acetate;

c phase material:

0.1-1 part of a second thickening agent;

0.1-1 part of a second humectant;

the first humectant consists of glycerin, 1, 2-pentanediol and sodium hyaluronate;

the second humectant consists of an extract of Haematococcus, an extract of brown algae and sorbitol;

the natural plant preservative consists of a gulfweed extract, an enteromorpha compressa extract and a lactobacillus/algae extract fermentation product;

the skin-moistening oil mixture consists of hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, Brazilian fruit seed oil and rosewood seed oil;

in the phase A material, the first thickening agent is an acryloyl dimethyl ammonium taurate/VP copolymer; in the C-phase material, the second thickening agent consists of sodium polyacrylate, mineral oil and laureth-6; in the phase B material, the emulsifier comprises at least one of cetearyl glucoside, cetearyl alcohol cornstalk glycoside and cetearyl alcohol.

2. The infant cream as claimed in claim 1, wherein the infant cream comprises the following components in parts by weight:

a phase material:

65-75 parts of water;

5.23-10.6 parts of a first humectant;

1-2 parts of a natural plant preservative;

0.1-0.3 part of first thickening agent;

0.01-0.05 part of disodium ethylene diamine tetraacetate;

0.1-0.3 part of allantoin;

b, phase material:

10.3-22.5 parts of emollient oil mixture;

2-6 parts of an emulsifier;

0.1-0.5 part of tocopherol acetate;

c phase material:

0.5-1 part of a second thickening agent;

0.5-1 part of second humectant.

3. The baby cream as claimed in claim 1 or 2, wherein in the phase A, the first humectant consists of glycerol, 1, 2-pentanediol and sodium hyaluronate in a weight ratio of 150: 160:3-4: 1.

4. The baby cream as claimed in claim 1 or 2, wherein in the B phase material, the emollient oil mixture is prepared from the following components in parts by weight of 25:15-15.8: 10-11: hydrogenated polydecene, caprylic/capric triglyceride, squalane, polydimethylsiloxane, brazilian fruit seed oil and rosewood seed oil at a ratio of 7.5:2-2.5: 1.

5. The baby cream according to claim 1 or 2, further comprising 0.01-0.1 parts by weight of essence.

6. A process for the preparation of a baby cream as claimed in any one of claims 1 to 2, comprising the steps of:

s1, fully mixing water, a first moisturizing agent, a natural plant preservative, a first thickening agent, ethylene diamine tetraacetic acid and allantoin in corresponding parts by weight at the temperature of 80-85 ℃ to form a phase A material;

7. The preparation process of the baby cream as claimed in claim 6, wherein in the step S5, after cooling to 40-45 ℃, 0.01-0.1 part by weight of essence is added and mixed uniformly.