CN105640796A - Composition with high moisture retention performance and application of composition to infant cream - Google Patents
Composition with high moisture retention performance and application of composition to infant cream Download PDFInfo
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- CN105640796A CN105640796A CN201610024238.7A CN201610024238A CN105640796A CN 105640796 A CN105640796 A CN 105640796A CN 201610024238 A CN201610024238 A CN 201610024238A CN 105640796 A CN105640796 A CN 105640796A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Abstract
The invention discloses a composition with high moisture retention performance and application of the composition to infant cream. The composition is prepared from 5-20 parts of chitosan, 10-30 parts of oat polypeptide, 5-20 parts of dendrobium polysaccharide, 0.5 part of hydroxyacetophenone, 0.5 part of hexylene glycol, 1.5 parts of butanediol and 30-70 parts of water. Chitosan, oat polypeptide, dendrobium polysaccharide and water are mixed to be uniform; hydroxyacetophenone, hexylene glycol and butanediol are mixed to be uniform and added to the solution obtained formerly, the mixture is stirred to be uniform, and the composition with high moisture retention performance is obtained. Different natural components in the composition have a coordination effect, the respective effects are improved, the natural product components are used in compatibility, safety and reliability are achieved, no stimulation effect is caused for skin of the human body, long-acting moisture retention performance and a certain antibacterial effect are achieved, and the composition is suitable for being used by a wide range of people and especially for infants.
Description
Technical field
The present invention relates to daily necessities field, particularly to a kind of compositions with humectant energy and the application in baby's cream thereof.
Background technology
After baby due, skin is not grown completely, will be about the time through 3 years, could grow to the level identical with adult. Compared with adult, the skin of baby has a characteristic that the skin area of 1. baby is relatively large, is 2 times of adult from the perspiration of skin evaporation, it is easier to lose moisture; 2. the water content of infant skin is higher than adult, needs special care in dry winter, such as cold wind stimulation, and protection in addition unsuitable again, the skin of child is just easy to cause chapping because of dehydration; 3. skin is had moist and protective effect by the sebum of smegma, and compared with adult, the sebaceous gland function of baby is inactive, and secretory volume is less, skin relatively dry, therefore baby nurses with greater need for doing skin moisture-keeping relative to adult. Owing to the skin of infant is tender and lovely especially, sensitive, thus the moisturizer safety issue of infant be research and development primarily control problem.
At present, on market, infant moisturizing class skin care item include frost, breast, wet goods type, and the composition wherein playing moisture-keeping function has had a lot, is generally divided into two classes, and a class is chemosynthesis wetting agent, such as polyalcohols; Another kind of is the wetting agent of plant and animal material, such as hyaluronic acid. The wetting agent of polyalcohols includes: propylene glycol, butanediol, sodium lactate, Sorbitol etc., they are chemosynthesis, it it not natural Organic substance, the concentration used in cosmetics is bigger, its skinfeel applying offer on skin is likely to glue very much, making user feel excessive greasy feeling, sense and drag Ta to feel, and derive from chemosynthesis, life-time service is likely to and can bring certain side effect. The wetting agent of plant and animal material includes: hyaluronic acid, collagen protein, adjoin pyrrolidone carboxylic acid's sodium etc., these in cosmetics the common wetting agent major part using more natural origin with animal for raw material, because of raw material is rare or complex process and cost is too high.
Therefore, along with the raising of consumer safety consciousness, efficient moisture-retention active component market demand natural origin, safe, cost is low increases day by day.
Summary of the invention
The primary and foremost purpose of the present invention is in that the shortcoming overcoming prior art is with not enough, it is provided that a kind of compositions with humectant energy.
Another object of the present invention is to the preparation method that the compositions of humectant energy is provided described in offer.
There is described in it is still another object of the present invention to provide the application of the compositions of humectant energy.
The purpose of the present invention is achieved through the following technical solutions: a kind of compositions with humectant energy, comprises following composition according to the mass fraction: chitosan 5��20 parts, oat polypeptide 10��30 parts, dendrobium polysaccharide 5��20 parts, fragrant fresh ketone 0.5 part, hexanediol 0.5 part, butanediol 1.5 parts, 30��70 parts of water.
The consumption of described water is preferably 42.5��62.5 mass parts.
The described compositions with humectant energy, it is preferable that comprise following composition according to the mass fraction: chitosan 15 parts, oat polypeptide 22.5 parts, dendrobium polysaccharide 15 parts, fragrant fresh ketone 0.5 part, hexanediol 0.5 part, butanediol 1.5 parts, 45 parts of water.
In the described compositions with humectant energy, the preferred 1:1.5:1 proportioning in mass ratio of described chitosan, described oat polypeptide and described dendrobium polysaccharide.
The preferred deacetylation of described chitosan is the chitosan of 80��95%. Chitosan has good solubility property and excellent performance of keeping humidity, also there is stable emulsifying, thickening, anlistatig effect, compatible good, and chitosan tool antisepsis, the moisturizing of its uniqueness and anti-microbial property are highly suitable in baby's moisturizing nursing product.
Described oat polypeptide is small active peptides, containing substantial amounts of hydrophilic group, to skin more permeability, and has more the effect of supplementary skin collagen, can strengthen the Water-saving effect of skin.
Described dendrobium polysaccharide is possible to prevent cell dehydration dead, has good performance of keeping humidity.
Described hexanediol is preferably 1,2-hexanediol.
Described butanediol is preferably 1,3 butylene glycol.
Raw material used all can from being commercially available on the market.
The preparation method of the described compositions with humectant energy, comprises the steps of:
(1) chitosan, oat polypeptide, dendrobium polysaccharide and water are mixed, heat to 50��70 DEG C of stirring and evenly mixings;
(2) fragrant fresh ketone, hexanediol and butanediol being mixed, heating, to 45��50 DEG C, stirs, joins while hot in the solution that step (1) obtains, stir, and obtains the compositions with humectant energy.
Described have humectant can compositions application in preparing cosmetics.
The dosage form of described cosmetics includes the dosage forms such as water preparation, Emulsion, unguentum.
The skin care item for baby that described cosmetics refer specifically to, such as baby skin protection cream, baby skin protection frost.
The addition of the described compositions with humectant energy is preferably 2��10% (w/w).
A kind of baby's active hydrating cream, is grouped into by following one-tenth by mass percentage:
A phase: water 53.94%, glycerol 2.5%, allantoin 0.2%, AVC 0.45%;
B phase: 1,3 butylene glycol 2.5%, xanthan gum 0.05%, hyaluronate sodium 0.01%;
C phase: Dormant oils 8%, polydimethylsiloxane 2%, isononyl isononanoate 2%, caprylic/capric triglyceride 3.5%, squalane 2%, cetearyl alcohol 2.3%, A165 emulsifying agent 2.3%, emulsifying agent RunemulFavorSC2.3%;
D phase: tocopherol acetas 0.5%, Fructus oleae europaeae fruit oil 1%, lanoline 1%, Butyrospermum parkii fruit fat 1%, vaseline 3.5%, Camellia oil 0.5%;
E phase: there is the compositions 7% of humectant energy, plant extract SenplantSD0.5%, preservative 0.85%;
F phase: essence 0.1%.
Described preservative is preferably EUXYLPE9010.
The preparation method of described baby's active hydrating cream, comprises the steps of:
(1) being mixed by each composition in B phase, somewhat stirring is to fully infiltration, standby;
(2) under 2000��3000rpm processing condition, the powder in A phase is spilled into, homogenizing 3-5 minute, note avoiding producing too much bubble, add pre-assigned B phase, heat while stirring, to 82-85 DEG C, homogenizing 3-5 minute is to being completely dispersed uniformly again, it is incubated at least sterilization in 15-20 minute, froth breaking, obtains A+B phase;
(3) weighing C phase raw material, mix homogeneously, heat while stirring to 78-80 DEG C, be stirred well to and be melt into liquid completely, before emulsifying, sequentially add D phase, stirring, to melting for liquid, insulation completely, obtains C+D phase;
(4), under vacuum, C+D is added in A+B phase, after adding, all uniform to complete emulsifying, insulation, cooling could be started after froth breaking; It is cooled to 45 DEG C, is sequentially added into E phase, stir under vacuum; It is cooled to less than 40 DEG C, adds F phase, stir, obtain baby's active hydrating cream.
A kind of baby skin protection frost, is grouped into by the one-tenth calculated by mass percentage as follows:
A ' phase: water 30.81%, allantoin 0.15%, AVC 0.5%;
B ' phase: methyl hydroxybenzoate 0.15%, propylene glycol 4%, glycerol 4%;
C ' phase: RunemulFavorLC3%, concentration are the sodium hydroxide solution 1.44% of mass percent 10%, water 20%, behenyl alcohol 2%, cetearyl alcohol ethylhexoate 7%, polydimethylsiloxane 2%, DC-62.5%, propyl hydroxybenzoate 0.1%;
D ' phase: triethanolamine 0.4%, water 15%;
E ' phase: polyacrylamide/C13-14 isoparaffin/lauryl alcohol-70.5%;
F ' phase: there is the compositions 6% of humectant energy, essence 0.05%, germall BP0.4%.
The preparation method of described baby skin protection frost, comprises the steps of:
(I) 2000-3000rpm condition below by A ' mutually in powder be spilled in cold water successively, heat while stirring again to 60-65 DEG C, homogenizing is to being completely dispersed uniformly, add the B phase obtained with each composition mix homogeneously of B phase in advance, continue heating to 82-85 DEG C, then homogenizing is to being completely dispersed uniformly, it is incubated at least sterilization in 15-20 minute, froth breaking, obtains A+B phase, standby;
(II) being mixed by the composition in C phase, heating is to 80-82 DEG C, after stirring is melt into liquid, and insulation, standby, add the D phase obtained with each composition mix homogeneously of D phase in advance before emulsifying, obtain C+D phase;
(III) under vacuum, being added to by C+D in A+B phase, after adding, homogenizing is uniform to complete emulsifying, is incubated 15 minutes, lowers the temperature after froth breaking; Being cooled to 70-75 DEG C, add E phase, under vacuum, 2000-4000rpm homogenizing is to uniformly; It is cooled to 45 DEG C, adds pre-assigned F phase, stir under vacuum, obtain baby skin protection frost.
The present invention has such advantages as and effect relative to prior art: the different natural constituents in the compositions with humectant energy provided by the invention have synergism, promote its each effect.Wherein chitosan has moisturizing, natural anticorrosion and antibacterial effect, oat polypeptide has pro-skin and long-acting moist effect, dendrobium polysaccharide has the effect of antioxidation moisturizing, above-mentioned natural products component compatibility uses, safe and reliable, human body skin is had no stimulation, there is long-acting performance of keeping humidity, for nursing skin particularly dry skin, there is good moisturizing and repair effect. And the compositions character with humectant energy of natural origin is gentle, it is to avoid cause inflammation and anaphylaxis, also there is certain fungistatic effect, be suitable to extensive crowd and use, be particularly suited for infant and use.
Accompanying drawing explanation
Fig. 1 is the performance of keeping humidity test result figure of the compositions of the humectant energy of embodiment 1��3.
Fig. 2 be embodiment 1 humectant can compositions and the performance of keeping humidity test result figure of comparative example 1��2.
Fig. 3 is application formula and contrast groups 1��2 performance of keeping humidity test result figure of the compositions 3 with humectant energy.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1 has the compositions 1 of humectant energy
(1) chitosan (deacetylation is 85%) of 5 mass parts is weighed, the oat polypeptide (content of peptides is 92%) of 30 mass parts, the dendrobium polysaccharide (polyoses content 80%) of 20 mass parts and 42.5 mass parts water, to container, heat to 50 DEG C of stirring and evenly mixings;
(2) the 0.5 fragrant fresh ketone of mass parts, 0.5 mass parts 1,2-hexanediol and 1.5 mass parts 1,3 butylene glycols are weighed, heating, to 45 DEG C, stirs, joins in the solution that step (1) obtains while hot, stir, obtain the compositions 1 with humectant energy.
Embodiment 2 has the compositions 2 of humectant energy
(1) chitosan (deacetylation is 85%) of 20 mass parts is weighed, the oat polypeptide (content of peptides is 92%) of 10 mass parts, the dendrobium polysaccharide (polyoses content 80%) of 5 mass parts and 62.5 mass parts water, to container, heat to 70 DEG C of stirring and evenly mixings;
(2) the 0.5 fragrant fresh ketone of mass parts, 0.5 mass parts 1,2-hexanediol and 1.5 mass parts 1,3 butylene glycols are weighed, heating, to 50 DEG C, stirs, joins in the solution that step (1) obtains while hot, stir, obtain the compositions 2 with humectant energy.
Embodiment 3: there is the compositions 3 of humectant energy
(1) chitosan (deacetylation is 85%) of 15 mass parts is weighed, 22.5 the oat polypeptide of mass parts (content of peptides is 92%), the dendrobium polysaccharide (polyoses content 80%) of 15 mass parts and 45 mass parts water, to container, heat to 60 DEG C of stirring and evenly mixings;
(2) the 0.5 fragrant fresh ketone of mass parts, 0.5 mass parts 1,2-hexanediol and 1.5 mass parts 1,3 butylene glycols are weighed, heating, to 50 DEG C, stirs, joins in the solution that step (1) obtains while hot, stir, obtain the compositions 3 with humectant energy.
Application Example 1
A kind of baby's active hydrating cream, formula is as shown in table 1:
Table 1
The preparation method of above-mentioned baby's active hydrating cream, as follows:
(1) being mixed by each composition in B phase, somewhat stirring is to fully infiltration, standby;
(2) under 2000��3000rpm processing condition, the powder in A phase is spilled into lentamente, homogenizing 3-5 minute (attention is avoided producing too much bubble), add pre-assigned B phase, heat while stirring, to 82-85 DEG C, then homogenizing 3-5 minute is to being completely dispersed uniformly, is incubated at least sterilization in 15-20 minute, froth breaking, obtains A+B phase;
(3) weigh C phase raw material, mix homogeneously, heat while stirring to 78-80 DEG C, be stirred well to and be melt into liquid completely, before emulsifying, sequentially add D phase, stirring to melting for liquid completely, insulation, standby; Avoid long-time high temperature, obtain C+D phase;
(4) under vacuum, stirring when 600rpm, 2000-3000rpm homogenizing, C+D phase is slowly added in A+B phase, and after adding, 4000-5000rpm homogenizing to complete emulsifying is uniformly incubated 10-15 minute in 5-10 minute, could start cooling after froth breaking; It is cooled to 45 DEG C, is sequentially added into E phase, stir under vacuum; It is cooled to less than 40 DEG C, adds F phase, stir; Sampling, detection, after qualified, discharging.
Application Example 2
A kind of baby skin protection frost, formula is as shown in table 2:
Table 2
The preparation method of above-mentioned baby skin protection frost, as follows:
Below the powder in A phase is spilled in cold deionized water successively lentamente in 2000-3000rpm condition, heating while stirring, period can carry out repeatedly the homogenizing of short time, to 60-65 DEG C again, homogenizing 5-8 minute is to being completely dispersed uniformly, add the B phase that obtains with each composition mix homogeneously of B phase in advance, continue heating to 82-85 DEG C, then homogenizing 2-5 minute is to being completely dispersed uniformly, it is incubated at least sterilization in 15-20 minute, froth breaking, obtains A+B phase, standby; Being mixed by composition in C phase, heating is to 80-82 DEG C, after stirring is melt into liquid, and insulation, standby, add the D phase obtained with each composition mix homogeneously of D phase in advance before emulsifying, obtain C+D phase, long-time heating should be avoided. Under vacuum, 600rpm stirs, homogenizing when 3000-5000rpm, and C+D phase is slowly added in A+B phase, and after adding, when 5000-6000rpm, homogenizing to complete emulsifying is uniformly incubated 15 minutes in 5-8 minute, lowers the temperature after froth breaking; Being cooled to 70-75 DEG C, add E phase, under vacuum, 2000-4000rpm homogenizing 1-3 minute is to uniformly; It is cooled to 45 DEG C, adds pre-assigned F phase, stir under vacuum; Sampling, detection, after qualified, discharging.
Effect example
To there is the compositions (embodiment 1��3) of humectant energy and containing the physical and chemical index of cosmetics (embodiment 4��5) of compositions of humectant energy, effect and security test
One, physical and chemical index test
Sensory testing: the character of perusal product, sees if there is exception;
Resistance to Thermal test: sample is put into 24h in the electro-heating standing-temperature cultivator of (40 �� 1) DEG C, has seen whether the phenomenons such as thinning, variable color, layering and firmness change, with the heat resistance of judgement sample after recovering room temperature;
Low temperature resistant test: sample is put into 24h in the electric refrigerator of (-5��-10) DEG C �� 1 DEG C, has seen whether the phenomenons such as thinning, variable color, layering and firmness change, with the cold tolerance of judgement sample after recovering room temperature;
Centrifugal test: be placed in centrifuge by sample, with the speed test 30min of (2000��4000) r/min, observes the separation of sample, layering situation.
Result is in Table 3, and the cosmetics embodiment 4��5 with the compositions embodiment 1��3 of humectant energy and the compositions containing humectant energy is all stable.
Table 3. embodiment 1��5 physical and chemical index test result
Two, efficacy test
1, moisture retention test
(1) the moisture retention test of the compositions 1��3 with humectant energy of embodiment 1��3
With hyaluronic acid (130��1,500,000 molecular weight) for positive control, deionized water is blank, investigate the moisture-retaining capacity of embodiment 1��3, it is configured to the aqueous solution of 1% (w/w) respectively, use the Multi-functional skin tester MPA10 of CK company of Germany, connect CorneometerCM825 moisture content test probe, moisture of skin test measures moisturizing degree according to QB/T4256-2011 " cosmetics moisture-keeping efficacy evaluation guide ", the compositions 1��3 with humectant energy contrasts each other, its moisture-retaining capacity is closely, and there is the compositions 1��3 of humectant energy.
(2) compositions 1 with humectant energy of variable concentrations embodiment 1 is tested with the moisture retention of blank group, comparative example 1 and comparative example 2;
Blank group is distilled water.
Comparative example 1: the difference with embodiment 1 be comparative example 1 chitosan-containing and oat polypeptide without dendrobium polysaccharide (dendrobium polysaccharide of water consumption substitution equivalent), other compositions (fragrant fresh ketone, hexanediol, butanediol) are the same with humectant energy compositions 1 with preparation method;
Comparative example 2: the difference with embodiment 1 be comparative example 2 chitosan-containing and dendrobium polysaccharide without oat polypeptide (oat polypeptide of water consumption substitution equivalent), other compositions are the same with humectant energy compositions 1 with preparation method;
In mass ratio respectively compound concentration be 1%, 3%, 5% embodiment 1, comparative example 1 and comparative example 2 aqueous solution, measuring the moisture retention of variable concentrations testing sample through skin moisture measurement according to QB/T4256-2011 " cosmetics moisture-keeping efficacy evaluation guide ", result is shown in Fig. 2.
By Fig. 2 result it can be seen that embodiment 1 is better along with increase (1%, 5%, the 10%) moisture retention of concentration; The embodiment 1 of same concentrations compares with the comparative example 1 of same concentrations, comparative example 2 moisture retention, embodiment 1 has significant performance of keeping humidity, illustrates that the moistening effect of the composite compositions of chitosan, oat polypeptide and dendrobium polysaccharide three plays the effect of Synergistic moisturizing.
(3) there is application formula (Application Example 1) the performance of keeping humidity test of the compositions 3 of humectant energy
With baby's active hydrating cream of the compositions with humectant energy of embodiment 4 for experimental group, increase blank group, contrast groups 1, contrast groups 2;
Blank group is the moisturiser formula without humectant energy compositions 3;
Contrast groups 1: from the difference of experimental group be add humectant energy compositions different, humectant energy compositions and the humectant energy compositions 3 that contrast groups 1 is added be distinctive in that nucleus containing only chitosan and oat polypeptide without the dendrobium polysaccharide (dendrobium polysaccharide of water consumption substitution equivalent, fragrant fresh ketone, hexanediol, butanediol are with humectant energy compositions 3), other compositions are the same with Application Example 1 with preparation method.
Contrast groups 2: from the difference of experimental group be add humectant energy compositions different, humectant energy compositions and the humectant energy compositions 3 that contrast groups 2 is added be distinctive in that nucleus containing only chitosan and dendrobium polysaccharide without the oat polypeptide (oat polypeptide of water consumption substitution equivalent, fragrant fresh ketone, hexanediol, butanediol are with humectant energy compositions 3), other compositions are the same with humectant energy compositions 3 with preparation method.
Blank group, contrast groups 1, contrast groups 2 Recipe the same with experimental group; Moisture of skin test measures moisturizing degree according to QB/T4256-2011 " cosmetics moisture-keeping efficacy evaluation guide ", and result is shown in Fig. 3.
From Fig. 3 application formula performance of keeping humidity test result, add have humectant can compositions prepared moisturiser than without have humectant can the moistening effect of moisturiser of compositions well a lot, and by chitosan, oat polypeptide and dendrobium polysaccharide three composite have humectant can the moistening effect of compositions play the effect of Synergistic moisturizing.
2, security test
(1) the skin irritation test of multiple dosing
Adopt zoopery, experimental animal adopts healthy Japan's big-ear white rabbit (purchased from Qingdao health mcroorganism Science and Technology Ltd.), takes rabbit 8, male and female half and half, it is randomly divided into 2 groups: intact skin group and damaged skin group, often group 4 by sex and body weight.Being administered first 24 hours, lost hair or feathers man's rabbit back both sides with 8% (mass percent) sodium sulfide, unhairing area is about 150cm2. During test, with knife blade lower regions, right side zone line each standardized " well " word cut on the left of damaged skin loses hair or feathers district's sterilization skin, cut is each about 2cm anyhow, with oozing of blood for degree. Two treated animals are all at depilation upper and lower region, the left side uniform application embodiment of the present invention 1 compositions 0.1g and Application Example 1 product 0.1g, and right side is smeared 1ml normal saline and compared, and every day at the upper and lower noon is respectively coated with once, continuous 7 days. During coating, animal divides cage to feed with full nutrient fodder. After medication 7 days, warm water washes away embodiment 1 and Application Example 1 product of residual on rabbit skin, detected by an unaided eye with after drug withdrawal 1,2,3,4,5,6,7 days and carry out histopathologic examination and record coating area skin with or without erythema and edema situation, carrying out skin irritation reaction scoring and intensity evaluation.
Skin irritation reaction standards of grading are as shown in table 4, and skin irritation intensity evaluation standard is as shown in table 5, and rabbit skin irritation reaction result is as shown in table 6.
Table 4
| Erythema | Score value | Edema | Score value |
| Without erythema | 0 | Without edema | 0 |
| Visible reluctantly | 1 | Visible reluctantly | 1 |
| Clearly visible | 2 | Visible (edge exceeds skin) | 2 |
| Poisoning or Severe erythema | 3 | Cutaneous protuberance is about 1mm, and profile is clear | 3 |
| Aubergine erythema also has eschar to be formed | 4 | Edema protuberance >=more than 1mm expanded range | 4 |
Table 5
Reaction mean scores=(erythema forms total score+edema and forms total score)/add up to number of animals
Table 6
Result of the test shows, uses the embodiment of the present invention 1 and Application Example 1 to rabbit intact skin and damaged skin nonirritant. Show that the present invention is to no skin irritation, safe and reliable.
2. human skin patch
Selecting 30 trial volunteers, 25��40 years old age, masculinity femininity half and half, subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria, carries out patch test. Select qualified patch device, with closed patch test method, by tested material embodiment 1, embodiment 2, each about 0.05g uniform application of embodiment 3 in patch device, external special adhesive tape is covered on experimenter's forearm, tested material is removed after 24 hours, within after removing respectively 0.5,6,12,24,48 hours, observe dermoreaction, record its result according to dermoreaction grade scale in " cosmetics health specification ".
Human skin patch result shows: 30 experimenters are by high-efficiency moisturizing composition of the present invention and moisturizing cream (Application Example 1��2) patch test, dermoreaction is observed at 0.5,6,12,24,48 hours, wherein there is skin adverse reaction in 0 example, illustrates that moisture-keeping cosmetics of the present invention uses safety.
Above-described embodiment is the present invention preferably embodiment; but embodiments of the present invention are also not restricted to the described embodiments; the change made under other any spirit without departing from the present invention and principle, modification, replacement, combination, simplification; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1. a compositions with humectant energy, it is characterised in that comprise following composition according to the mass fraction: chitosan 5��20 parts, oat polypeptide 10��30 parts, dendrobium polysaccharide 5��20 parts, fragrant fresh ketone 0.5 part, hexanediol 0.5 part, butanediol 1.5 parts, 30��70 parts of water.
2. there is the compositions of humectant energy according to claim 1, it is characterised in that: the consumption of described water is 42.5��62.5 mass parts.
3. there is the compositions of humectant energy according to claim 1, it is characterised in that comprise following composition according to the mass fraction: chitosan 15 parts, oat polypeptide 22.5 parts, dendrobium polysaccharide 15 parts, fragrant fresh ketone 0.5 part, hexanediol 0.5 part, butanediol 1.5 parts, 45 parts of water.
4. there is the compositions of humectant energy according to any one of claims 1 to 3, it is characterized in that: in the described compositions with humectant energy, described chitosan, described oat polypeptide and described dendrobium polysaccharide 1:1.5:1 proportioning in mass ratio.
5. there is the compositions of humectant energy according to claim 4, it is characterised in that: described chitosan is deacetylation is the chitosan of 80��95%.
6. the preparation method described in any one of Claims 1 to 5 with the compositions of humectant energy, it is characterised in that comprise the steps of:
(1) chitosan, oat polypeptide, dendrobium polysaccharide and water are mixed, heat to 50��70 DEG C of stirring and evenly mixings;
(2) fragrant fresh ketone, hexanediol and butanediol being mixed, heating, to 45��50 DEG C, stirs, joins while hot in the solution that step (1) obtains, stir, and obtains the compositions with humectant energy.
7. have described in any one of Claims 1 to 5 humectant can compositions application in preparing cosmetics.
8. have according to claim 7 humectant can compositions application in preparing cosmetics, it is characterised in that: described cosmetics are skin care item for baby.
9. baby's active hydrating cream, it is characterised in that be grouped into by following one-tenth by mass percentage:
A phase: water 53.94%, glycerol 2.5%, allantoin 0.2%, AVC 0.45%;
B phase: 1,3 butylene glycol 2.5%, xanthan gum 0.05%, hyaluronate sodium 0.01%;
C phase: Dormant oils 8%, polydimethylsiloxane 2%, isononyl isononanoate 2%, caprylic/capric triglyceride 3.5%, squalane 2%, cetearyl alcohol 2.3%, A165 emulsifying agent 2.3%, RunemulFavorSC2.3%;
D phase: tocopherol acetas 0.5%, Fructus oleae europaeae fruit oil 1%, lanoline 1%, Butyrospermum parkii fruit fat 1%, vaseline 3.5%, Camellia oil 0.5%;
E phase: any one of Claims 1 to 5 has the compositions 7% of humectant energy, SenplantSD0.5%, preservative 0.85%;
F phase: essence 0.1%.
10. a baby skin protection frost, it is characterised in that be grouped into by the one-tenth calculated by mass percentage as follows:
A ' phase: water 30.81%, allantoin 0.15%, AVC 0.5%;
B ' phase: methyl hydroxybenzoate 0.15%, propylene glycol 4%, glycerol 4%;
C ' phase: RunemulFavorLC3%, concentration are the sodium hydroxide solution 1.44% of mass percent 10%, water 20%, behenyl alcohol 2%, cetearyl alcohol ethylhexoate 7%, polydimethylsiloxane 2%, DC-62.5%, propyl hydroxybenzoate 0.1%;
D ' phase: triethanolamine 0.4%, water 15%;
E ' phase: polyacrylamide/C13-14 isoparaffin/lauryl alcohol-70.5%;
F ' phase: any one of Claims 1 to 5 has the compositions 6% of humectant energy, essence 0.05%, germall BP0.4%.
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| CN106619477A (en) * | 2016-12-23 | 2017-05-10 | 金日制药（中国）有限公司 | Multipurpose isolating and moisturizing spray and preparation method thereof |
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| CN106619477A (en) * | 2016-12-23 | 2017-05-10 | 金日制药（中国）有限公司 | Multipurpose isolating and moisturizing spray and preparation method thereof |
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| CN106890122B (en) * | 2017-03-27 | 2019-12-06 | 广州天玺生物科技有限公司 | skin soothing and itching relieving gel and preparation method thereof |
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| CN108078828A (en) * | 2017-12-29 | 2018-05-29 | 厦门嘉宝莱化妆品有限公司 | A kind of baby's frost and its preparation process |
| CN108078828B (en) * | 2017-12-29 | 2021-07-30 | 厦门嘉宝莱化妆品有限公司 | Baby cream and preparation process thereof |
| CN108158862A (en) * | 2018-03-15 | 2018-06-15 | 深圳市婴缘健康有限公司 | A kind of infant's emollient cream |
| CN108888575A (en) * | 2018-08-09 | 2018-11-27 | 福建樱幼佳科技有限公司 | A kind of baby skin protection product and preparation method thereof |
| CN108721150A (en) * | 2018-08-28 | 2018-11-02 | 广州市华晟健康产业有限公司 | A kind of baby containing olive extract moistens frost again |
| CN108743493A (en) * | 2018-08-30 | 2018-11-06 | 广州市华晟健康产业有限公司 | A kind of children's pro-skin breast containing the newborn wooden fruit |
| CN108969418A (en) * | 2018-08-30 | 2018-12-11 | 广州市华晟健康产业有限公司 | A kind of moist cream of the baby containing olive extract |
| CN114432214A (en) * | 2020-11-03 | 2022-05-06 | 广州樱奈儿化妆品有限公司 | Dendrobium anti-allergy skin-moistening cream for infants and preparation method thereof |
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Effective date of registration: 20170519 Address after: 528437, Guangdong Torch Development Zone, Zhongshan national health base, one of the health Road 9, 2 industrial buildings 318 rooms Patentee after: Zhongshan care for children health science and Technology Research Co Ltd Address before: 528303 national health base, Torch Development Zone, Guangdong, Zhongshan Province, No. 9 health Road Patentee before: Zhongshan Aihu Commodity Co., Ltd. |
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