CN106727164A - A kind of moisture-keeping composition and its preparation method and application - Google Patents
A kind of moisture-keeping composition and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The present invention relates to a kind of moisture-keeping composition and its preparation method and application, belong to cosmetic field.Component of the moisture-keeping composition of the invention comprising following weight portion meter：1.0 5.0 parts of Sodium Hyaluronate, 2.0 10.0 parts of carboxymethylchitosan, 30.0 60.0 parts of dendrobium candidum extract, 25.0 67.0 parts of deionized water.The present invention preferably can form a netted natural Biomimetic membranes with skin, Sodium Hyaluronate replenishing water and preserving moisture inside Biomimetic membranes, carboxymethylchitosan forms bionical sterile film, effectively block the NMFs such as Sodium Hyaluronate, reduce percentage of water loss, Dendrobium officinale polysaccharide is combined moisturizing persistence, the enhancing repairing effect for further improving long-term use with natural bionical sterile film simultaneously, fundamentally solves dry skin, allergic problem.This moisture-keeping composition has moisturizing, reparation, various dimensions effect of enhancing skin barrier function.
Description
Technical field
The present invention relates to moisture-keeping composition, and in particular to a kind of moisture-keeping composition and its preparation method and application, belonging to
Cosmetic technical field.
Background technology
With the progress and development of society, the increasingly raising of living standard, cosmetics more and more turn into modern life
An indispensable part.At the same time, sensitiveness skin proportion is also being continuously increased, and laser beautifying, tartaric acid are changed in addition
The factors such as skin, environmental pollution, seasonal variations and improper maintenance cause skin barrier be damaged, then occur skin itch, it is red, swollen,
The phenomenons such as heat, pain.Therefore requirement of the people to cosmetics quality and its performance also more and more higher, it would be desirable to occur to health
Harmless, moisture-retaining capacity is excellent, lasting, while have that again skin barrier function is repaired, and suitable for sensitiveness skin, can be effective
The cosmetics of the phenomenons such as alleviation is itched, red, swollen, hot, pain.
Chinese patent CN102018652B discloses a kind of binary moisturizing system skin care item, and the skin care item are by leucojum aestivum
Bulb extract, sponge extract, sodium lactate and pentanediol composition.The Moisturizer can be in skin surface water lock, bottom
Moisturizing, forms binary moisturizing system.But leucojum aestivum bulb extract and sponge extract are oxidizable, moistening effect continuation
It is poor, it is impossible to reach requirement of the modern to moisturizing moisturizing effect, at the same to itching, it is red, swollen, hot, pain etc. phenomenon reparation make
With little, it is unfavorable for the application and popularization of the binary moisturizing system skin care item.
The content of the invention
For prior art moisture-keeping cosmetics effect is single, percentage of water loss is high and the shortcoming of moisturizing persistence difference, the present invention
Purpose be to provide a kind of moisturizing on skin barrier, repair synergistic function moisture-keeping composition.
The purpose of the present invention is achieved through the following technical solutions：
A kind of moisture-keeping composition, comprising following component by weight：
Preferably, the carboxymethylchitosan is the chitin polysaccharide extracted from marine organisms first through de-
Acetylation, then be chemically modified to obtain through carboxymethylated.
Preferably, polysaccharide content of dendrobium candidum is 0.3-0.5% in the dendrobium candidum extract.
Further preferably, the present composition includes following component by weight：
It is a further object to provide the preparation method of the moisture-keeping composition, comprise the following steps：
(1) by Sodium Hyaluronate addition deionized water, heating for dissolving is uniform,
(2) after lowering the temperature, carboxymethylchitosan and the dissolving of dendrobium candidum extract is added to stir, you can.
Preferably, it is heated to 80-85 DEG C in step (1).
Preferably, it is cooled to 40-45 DEG C in step (2).
Another object of the present invention is the application of the moisture-keeping composition, and the moisture-keeping composition is applied to skin care item
In.
Preferably, the skin care item are essence lotion, moisturiser, toner, facial mask, eye cream, stoste, mildy wash, emulsion, breast
Cream, hydrosol, sun screen or BB frost.
Preferably, the skin care item include by weight：The moisture-keeping composition 5.0-10.0% of claim 1, cosmetic
Product matrix 72.0-90.0% and cosmetic 0.02-20.0%.
Preferably, the cosmetic includes surfactant (natural surfactant：Lecithin, saponin, alkyl
Glycosides；Synthetic surfactant：Anion, cation, nonionic surfactant, such as stearine, PEG-100 stearic acid
Ester (stearate of polyoxyethylene 100), Sucrose Polystearic Acid Esters, docosyl alcohol polyethers -25 etc.), (such as animality is natural for essence and flavoring agent
Spices：Moschus etc.；Vegetal natural perfume：Attar of rose, peppermint oil, spearmint oil, lavender oil, fennel oil etc.；Synthetic perfume
Chamomile essence, oriental cherry essence etc.), colouring agent, NMF (such as glycerine, propane diols, 1,3 butylene glycol, sorbierite, poly- second two
Alcohol, lactic acid and sodium lactate, pyrrolidone sodium carboxylate, glucose esters, ethoxy urea, glycine betaine etc.), skin conditioning agent is (as bitter
Ginseng extract solution, phytosterols oletate, oriental cherry extract solution, boron nitride etc.), antioxidant (such as butylated hydroxy anisole, the tert-butyl group
Hydroxy-methylbenzene, vitamin E, propylgallate, Butylated Hydroxytoluene, tocopherol acetate), preservative (such as 1,2- hexylene glycols, imidazoles
Ureine, parahydroxyacet-ophenone, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, Sensiva SC50 etc.), sun-screening agent, thickener
One or more mixing in (such as Carbomer, xanthans, Sodium Polyacrylate), pH adjusting agent (such as triethanolamine)
Thing.
Preferably, the cosmetic base includes oiliness class, powder class, solvent matrix.
It is further preferred that the oiliness class matrix includes coconut oil, castor oil, olive oil, palm oil, mink oil, snake
Oil, tallow, lanolin and its derivative, Brazil wax, beeswax, atoleine, vaseline, saualane, silicone oil and its derivative
Thing, fatty alcohol, aliphatic acid, different ethylhexyl palmitate, dimethyl silicone polymer, cetostearyl alcohol, cetanol, cetanol ethyl
Capronate, glycerine three (thylhexoic acid) ester, camellia seed oil etc..
It is further preferred that the powder class matrix is including talcum powder, territory high, zinc white, titanium dioxide, calcium carbonate/magnesium etc..
It is further preferred that the solvent matrix is including water, alcohols (alcohol, isopropanol, n-butanol), ether, esters etc..
Moisture-keeping composition of the invention enters skin, is combined with the moisture in cell, reduces the evaporation of moisture in cell, increases
The moisture-keeping functions of strong skin.Dermal matrix cell can be repaired simultaneously, promote the synthesis of glutinous polysaccharide, collagen and elastin laminin.Improve
The tissue and structure of epidermis and skin corium, so as to reach excellent replenishing water and preserving moisture, repair the effect of skin, enhancing skin barrier
Effect.
Hyaluronic acid (hyaluronic acid, HA) is one of constituent of human body skin, is that distribution is most wide in human body
A kind of acidic mucopolysaccharide, be present in connective tissue matrix, be described as preferable NMF (natural
Moisturizing factor, NMF), Sodium Hyaluronate is the sodium salt of hyaluronic acid, with following effect：
(1) moisturizing：Moisturizing is Sodium Hyaluronate most important effect in cosmetics.It is transparent compared with other NMFs
The characteristics of matter acid sodium is that influence of the relative humidity of surrounding environment to its moisture retention is smaller.This unique property is adapted to different seasons
Section, varying environment humidity (summer of such as dry winter and humidity) requirement of the skin to cosmetics moisture-keeping function.
(2) prevent and reparation skin injury：Sodium Hyaluronate is by promoting epidermal cell proliferation and breaking up and removing oxygen
Free radical, can promote injury skin regeneration.When skin is damaged, smearing the aqua cosmetics containing Sodium Hyaluronate can subtract
Light pain, accelerates the healing of injury.
(3) skin nutrition：Sodium Hyaluronate is the intrinsic biological substance of skin, and what is contained in human epidermal and corium is transparent
Matter acid sodium total amount accounts for more than half of Sodium Hyaluronate, and the water content of skin is directly related with the content of Sodium Hyaluronate.With
Age increases, skin aging, and hyaluronic acid sodium content declines in skin, causes moisture content of skin to reduce.Commonly using containing saturating
The cosmetics of bright matter acid sodium, can increase moisture of skin, keep skin wet, keep the moisture in skin, promote nutriment
Supply and unwanted metabolite thing excretion, so as to prevent skin aging, play a part of beauty and beauty treatment.
(4) lubricity and film forming：Sodium Hyaluronate is high molecular polymer, there is certain lubricity and film forming.Apply
When smearing the cosmetics containing Sodium Hyaluronate, thin film can be formed in skin surface, be allowed to produce good smooth and moist feeling,
Play a part of to protect skin.
(5) anti-inflammation function：Sodium Hyaluronate is combined in dermal matrix with protein, in protein complex form
It is present in space between cells, forms gel, the effect of cell metabolism of bringing into normal play and tissue water holding makes by cell adhesion together
Skin Cell prevents infection from invading pathogens.
Sodium Hyaluronate has above effect, but Sodium Hyaluronate facile hydrolysis and film forming is excellent not enough, moisturizing
Percentage of water loss is higher simultaneously, so that the moistening effect of Sodium Hyaluronate is not lasting enough.
Carboxymethylchitosan is the chitin polysaccharide that is extracted from marine organisms and (is first taken off through chemical modification
Acetylation, then carboxy methylation) obtain, its result is as follows.Chitin is a kind of inexhaustible, nexhaustible renewable
Living resources, but chitin polysaccharide in aqueous insoluble, are limited by very large it, through chemical modification and repair
The carboxymethylchitosan of decorations has good water solubility, using will have huge potentiality and apply valency in cosmetics
Value, it has following effect.
(1) because component units composition Glucosamine and human epidermal the adipose membrane layer of carboxymethylchitosan are important
The structure of composition ceramide is closely similar, therefore it can interact with epidermal lipid film layer, and one layer of formation is excellent naturally to be imitated
Rawhide skin (natural sterile film), complexing heavy metal effectively removes the toxin for entering skin, can effectively block hyalomitome
The NMFs such as sour sodium, fully keep skin moisture and nutritional ingredient, reduce percentage of water loss, prevent dry skin.
(2) moisture-retaining capacity and penetrating power are balanced with stronger deep layer, and is easily absorbed by the skin, can keep skin
Sufficient moisture is nourished.
(3) with immunoregulatory activity, wound healing can be effectively facilitated.Carboxymethylchitosan can increase human body skin
Skin causes the immunity of infection to bacterium, fungi, hinders opportunistic pathogen growth, and infection will not be not only caused to damaged skin, also has
There are itching-relieving efficacies, while promoting wound healing, eliminate dermatopathy.
Carboxymethylchitosan film forming is very good, can form one layer of natural bionical sterile film in skin surface, can
The NMFs such as Sodium Hyaluronate are blocked with effective, intracellular moisture is further pinned, skin is more preferably reduced
Percentage of water loss, so as to greatly prolong moisture preserving time.
Dendrobium candidum is listed in " first of Chinese nine big celestial grass ", many containing abundant dendrobium candidum in dendrobium candidum extract
Sugar, its polyoses content is higher than other kind stems of noble dendrobium, and Dendrobium officinale polysaccharide has following effect：
(1) metabolism and internal system are adjusted, improve significantly work to acne, inflammation skin and coarse skin tool
With.
(2) with excellent moisturizing, repair and oxidation resistant effect and stable in properties, supplement skin water can be continued
Point, the moisture of skin can be increased during long-term use, improve elasticity of skin and plumpness.
Moisture-keeping composition of the invention includes Sodium Hyaluronate, carboxymethylchitosan, three kinds of Dendrobium officinale polysaccharide
Active component, by the formula system for optimizing, can be by Sodium Hyaluronate excellent moisturizing moisturizing, carboxymethylchitosan
Excellent film forming and Dendrobium officinale polysaccharide long-term use lasting moisturizing prosthetic produce Synergistic effect, fully hair
The each unique advantage of these three active components is waved, carboxymethylchitosan film forming is very good, can be in skin surface shape
Into one layer of natural bionical sterile film, the NMFs such as Sodium Hyaluronate can be effectively blocked, reduce percentage of water loss, while
Dendrobium officinale polysaccharide is combined persistence, the enhancing repairing effect for further improving moisturizing with natural bionical sterile film, and anti-anaphylaxis resists
Quick effect is more excellent.
Beneficial effects of the present invention：
Instant invention overcomes moisture-keeping cosmetics on the market effect is single, percentage of water loss is high and the shortcoming of moisturizing persistence difference.
Moisture-keeping composition of the present invention preferably can form a netted natural Biomimetic membranes with skin, and Sodium Hyaluronate is mended inside Biomimetic membranes
Water moisturizing, while carboxymethylchitosan forms bionical sterile film, can effectively block Sodium Hyaluronate etc. natural
Moisturizing factor, reduces percentage of water loss, while Dendrobium officinale polysaccharide is combined with natural bionical sterile film further improves long-term use
Moisturizing persistence, enhancing repairing effect, fundamentally solve dry skin, allergic problem.Moisture-keeping composition tool of the invention
There are moisturizing, reparation, various dimensions effect of enhancing skin barrier function.
Specific embodiment
Below by way of specific embodiment, the invention will be further described, but the present invention is not limited only to following examples.
Moisture-keeping composition A of the invention includes following component by weight：
Moisture-keeping composition A of the invention is prepared according to following preparation method：
(1) by Sodium Hyaluronate addition deionized water, it is heated to 80-85 DEG C and is uniformly dissolved,
(2) after being cooled to 40-45 DEG C, carboxymethylchitosan and Dendrobium officinale polysaccharide dissolving is added to stir,
.
Embodiment 1
Essence lotion, the component comprising following parts by weight are repaired in moisturizing：Composition A5.0 parts, 3.0 parts of glycerine, 1,3- fourths two
5.0 parts of alcohol, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, 82.45 parts of deionized water, 0.40 part of parahydroxyacet-ophenone, hydroxyl second
3.0 parts of base urea.
The preparation method of essence lotion is repaired in the moisturizing：After with glycerine, the pre-dispersed Carbomer of 1,3-BDO, addition is gone
Ionized water is heated to 85 DEG C, stirs, and adds and uses the pre-dispersed good parahydroxyacet-ophenone of 1,2- hexylene glycols, stirs,
Cool to 45 DEG C, add ethoxy urea, moisture-keeping composition A of the invention and stir.
Embodiment 2
Moisturizing repair latex, the component comprising following parts by weight：
Component A：81.57 parts of water, 5.0 parts of 1,3-BDO, 1.0 parts of glycerine, 0.1 part of xanthans, 0.1 part of methyl hydroxybenzoate.
B component：1.0 parts of saualane, 1.0 parts of different ethylhexyl palmitate, 1.0 parts of dimethyl silicone polymer, Butylated Hydroxytoluene
0.1 part, 0.1 part of Nipasol, 1.0 parts of cetostearyl alcohol, 0.5 part of stearine, PEG-100 stearates (polyoxy second
The stearate of alkene 100) 0.5 part, 0.4 part of cetanol, 0.1 part of tocopherol (vitamin E), 0.1 part of camellia seed oil.
Component C：1.0 parts of Radix Sophorae Flavescentis extractive liquid, moisture-keeping composition A5.0 parts of the invention, 0.3 part of Phenoxyethanol, ethylhexyl
0.1 part of glycerine 0.03, chamomile essence.
The preparation method of the moisturizing repair latex：By 1,3-BDO, glycerine, xanthans, oxybenzene in component A under normal temperature
Methyl esters mixes, and moistening is uniform, adds to emulsification pot, adds remaining deionized water in component A, is heated to 80-85 DEG C of stirring
Uniformly, 10 minutes are incubated；Each component in B component is added sequentially to oil phase reactor and is heated to 80 DEG C, stirring is to completely molten
Liquid, under vacuum, under the mixing speed of 200rpm, B component in oil phase reactor is slowly added to the emulsification pot of component A
In, adding rear mixing speed and carry to 600rpm, homogeneous 5 minutes emulsifies system uniform, and 82 DEG C are incubated 10 minutes, are dropped after froth breaking
Temperature；Less than 45 DEG C are cooled to, are sequentially added and stir under each component of component C, vacuum, then in the stirring speed of 500rpm
The lower homogeneous of degree obtains preserving moisture and protecting skin emulsion in 10 seconds.
Embodiment 3
Moisturizing repair cream, the component comprising following parts by weight：
Component A：61.47 parts of water, 4.0 parts of 1,3-BDO, 5.0 parts of glycerine, 0.5 part of glycine betaine, 0.1 part of methyl hydroxybenzoate.
B component：7.0 parts of cetanol ethylhexoate, 4.0 parts of glycerine three (thylhexoic acid) ester, dimethyl silicone polymer 3.0
Part, 2.0 parts of cetostearyl alcohol, 0.1 part of Nipasol, 1.5 parts of Sucrose Polystearic Acid Esters, 2.0 parts of phytosterols oletate, behenyl
- 25 1.5 parts of alcohol polyethers, 1.0 parts of boron nitride, 0.5 part of tocopherol acetate, 0.4 part of Sodium Polyacrylate.
Component C：0.5 part of oriental cherry extract solution, moisture-keeping composition A5.0 parts of the invention, 0.3 part of Phenoxyethanol, ethylhexyl
0.1 part of glycerine 0.03, oriental cherry essence.
The preparation method of the moisturizing repair cream：By 1,3-BDO, glycerine, glycine betaine, oxybenzene first in component A under normal temperature
Ester mixes, and moistening is uniform, adds to emulsification pot, adds remaining deionized water in component A, is heated to 80-85 DEG C of stirring equal
It is even, it is incubated 10 minutes；Each component in B component is added sequentially to oil phase reactor and is heated to 80 DEG C, stirring to it is completely molten be liquid
Body, under vacuum, under the mixing speed of 200rpm, B component in oil phase reactor is slowly added into the emulsification pot of component A,
Add rear mixing speed to carry to 600rpm, homogeneous 5 minutes emulsifies system uniform, and 82 DEG C are incubated 10 minutes, lower the temperature after froth breaking；
Less than 45 DEG C are cooled to, are sequentially added and stir under each component of component C, vacuum, then in the mixing speed of 500rpm
Lower homogeneous obtains moisturiser in 10 seconds.
Comparative example 1
Essence lotion is repaired in moisturizing, comprising following component by weight：0.2 part of Sodium Hyaluronate, 3.0 parts of glycerine, 1,
5.0 parts of 3- butanediols, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, 87.25 parts of deionized water, parahydroxyacet-ophenone 0.40
Part, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：With glycerine, the pre-dispersed Carbomer of 1,3-BDO and hyaluronic acid
After sodium, add deionized water to be heated to 85 DEG C, stir, add the para hydroxybenzene second for using 1,2- hexylene glycols pre-dispersed
Ketone, stirs, and cools to 45 DEG C, adds ethoxy urea and stirs.
Comparative example 2
Essence lotion is repaired in moisturizing reparation, comprising following component by weight：0.3 part of carboxymethylchitosan,
3.0 parts of glycerine, 5.0 parts of 1,3-BDO, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, 87.15 parts of deionized water, to hydroxyl
0.40 part of acetophenone, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：After with glycerine, the pre-dispersed Carbomer of 1,3-BDO, addition is gone
Ionized water is heated to 85 DEG C, stirs, and adds the parahydroxyacet-ophenone for using 1,2- hexylene glycols pre-dispersed, stirs, cold
But 45 DEG C are cooled to, ethoxy urea are added and carboxymethylchitosan is stirred.
Comparative example 3
Essence lotion is repaired in moisturizing, comprising following component by weight：2.0 parts of dendrobium candidum extract, glycerine 3.0
Part, 5.0 parts of 1,3-BDO, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, 85.45 parts of deionized water, parahydroxyacet-ophenone
0.40 part, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：After with glycerine, the pre-dispersed Carbomer of 1,3-BDO, addition is gone
Ionized water is heated to 85 DEG C, stirs, and adds the parahydroxyacet-ophenone for using 1,2- hexylene glycols pre-dispersed, stirs, cold
But 45 DEG C are cooled to, ethoxy urea are added and dendrobium candidum extract is stirred.
Comparative example 4
Essence lotion, the component comprising following parts by weight are repaired in moisturizing：0.2 part of Sodium Hyaluronate, the deacetylated shell of carboxymethyl
0.3 part of polysaccharide, 3.0 parts of glycerine, 5.0 parts of 1,3-BDO, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, deionized water
86.95 parts, 0.40 part of parahydroxyacet-ophenone, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：With glycerine, the pre-dispersed Carbomer of 1,3-BDO and hyaluronic acid
After sodium, add deionized water to be heated to 85 DEG C, stir, add the para hydroxybenzene second for using 1,2- hexylene glycols pre-dispersed
Ketone, stirs, and cools to 45 DEG C, adds ethoxy urea, carboxymethylchitosan and stirs.
Comparative example 5
Essence lotion, the component comprising following parts by weight are repaired in moisturizing：0.2 part of Sodium Hyaluronate, dendrobium candidum extract
2.0 parts, 3.0 parts of glycerine, 5.0 parts of 1,3-BDO, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, 85.25 parts of deionized water,
0.40 part of parahydroxyacet-ophenone, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：With glycerine, the pre-dispersed Carbomer of 1,3-BDO and hyaluronic acid
After sodium, add deionized water to be heated to 85 DEG C, stir, add the para hydroxybenzene second for using 1,2- hexylene glycols pre-dispersed
Ketone, stirs, and cools to 45 DEG C, adds ethoxy urea, dendrobium candidum extract and stirs.
Comparative example 6
Essence lotion, the component comprising following parts by weight are repaired in moisturizing：0.3 part of carboxymethylchitosan, iron sheet stone
2.0 parts of dry measure used in former times extract, 3.0 parts of glycerine, 5.0 parts of 1,3-BDO, 0.15 part of Carbomer, 1.0 parts of 1,2- hexylene glycols, deionized water
85.15 parts, 0.40 part of parahydroxyacet-ophenone, 3.0 parts of ethoxy urea.
The preparation method of essence lotion is repaired in the moisturizing：After with glycerine, the pre-dispersed Carbomer of 1,3-BDO, addition is gone
Ionized water is heated to 85 DEG C, stirs, and adds the parahydroxyacet-ophenone for using 1,2- hexylene glycols pre-dispersed, stirs, cold
But 45 DEG C are cooled to, ethoxy urea, carboxymethylchitosan and dendrobium candidum extract are added and is stirred.
The human body application of test example 1 is tested
1. test method：The people of volunteer 240 (one full year of life at age 25-40), is randomly divided into 8 groups, often by the principle of parallel control
30 people of group, repair essence lotion, embodiment 1, comparative example 1, comparative example 2, comparative example 3, comparative example 4, right using commercially available moisturizing respectively
Essence lotion is repaired in the moisturizing of ratio 5 and comparative example 6.0.8-1.2g is respectively taken after experiment volunteer's morning and evening face cleaning and be applied to face, make
With 4 weeks, respectively test smear before (0 week), smear 1 week after, smear 2 weeks after, smear 3 weeks after, smear 4 weeks after, after 8 weeks (smearing 4
Zhou Houzai pauses are using after 4 weeks) situation of skin moisture content and skin elasticity index, every time 5 data of test average.
2. instrument：Skin moisture tester Corneometer CM825, German COURAGE+KHAZAKA (CK) company；Skin
Skin elasticity tester Cutometer dual MPA580, German COURAGE+KHAZAKA (CK) company.
3. result of the test：Skin moisture increases percentage amounts to volunteer and elasticity indexes increase percentage amounts refer to table 1 weekly.Table
Middle evaluation index slightly improves and is obviously improved two grades including skin, and number is superimposed with accumulated time.Slightly improve and refer to
Have improvement on the premise of compared with (0 week) before test skin moisture increase percentage amounts<5%, elasticity indexes increase percentage amounts<5%；
It refers to that skin moisture increases percentage amounts >=5% compared with (0 week) before test to be obviously improved, and elasticity indexes increase percentage amounts >=5%
(two are satisfied by), slightly improves and is obviously improved and be misaligned.
Skin improves degree to the volunteer of table 1 weekly
As shown in Table 1, the improvement that essence lotion repairs essence lotion with commercially available moisturizing is repaired in the moisturizing of comparative example 1 and comparative example 2
Less, and commercially available moisturizing repairs essence lotion, comparative example 1, comparative example 2 and comparative example 3 substantially not as comparative example 4, right to situation difference
Essence lotion is repaired in the moisturizing of ratio 5 and comparative example 6, and this is due to Sodium Hyaluronate, carboxymethylchitosan, dendrobium candidum
When extract is compounded two-by-two, the effect of certain Synergistic is served.As seen from the table, skin moisture content add percentage amounts and
Elasticity indexes increase percentage amounts most preferably embodiment 1, and can equally be protected (after suspending again after smearing 4 weeks using 4 weeks) after 8 weeks
Holding good skin moisture content plus percentage amounts and elasticity indexes increases percentage amounts, and this is because Sodium Hyaluronate, carboxymethyl take off
Chitosan, dendrobium candidum extract three have reached the effect of more preferable Synergistic when compounding, give full play to these three
The each unique advantage of active component, good moisturizing is served during use and the effect of skin elasticity is safeguarded, and
Using after 4 weeks disable 4 weeks after in the case of, equally can keep good skin moisture content and elasticity.
The clinical effect observation of the anti-anaphylaxis desensitization of test example 2
Selecting skin of face has a women 400 of rubescent 20-50 one full year of life of allergic symptom such as itch, it is on probation before carry out routine
Inspection Check：Just conventional, hepatic and renal function is showed no exception for electrocardiogram, blood urine.400 people are randomly divided into eight groups, every group of difference daily morning Dinner
Essence lotion, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5, contrast are repaired after face cleaning using commercially available moisturizing respectively
The moisturizing of example 6 and embodiment 1 repairs essence lotion uniform application in face, treats that nature is absorbed without cleaning, continuous to use 28 days, examination
Edible irritable food is avoided with period, without other cosmetics.Statistics is shown in Table 2.
Curative effect determinate standard：
Cure：It is wholly absent with rear inspection Check rubefactions symptom of itching, Continuous Observation does not recur for 7 days；
It is effective：Substantially mitigated with rear symptom；
It is invalid：With rear symptom without mitigation, or there is exacerbation.
The clinical observation on the therapeutic effect of table 2
As shown in Table 2,21 people's allergic symptoms are wholly absent in 50 people that essence lotion is repaired using the moisturizing of embodiment 1,
25 people's allergic symptoms are clearly better, and the change of 4 people's allergic symptoms is little, and total effective rate is up to 92%, and essence lotion is repaired in commercially available moisturizing
Total effective rate is only 58%, and the total effective rate of comparative example 1 is only the total effective rate of 56%, comparative example 2 for 72%, comparative example 3 is total effectively
Rate is that the 54%, total effective rate of comparative example 4 is that the 78%, total effective rate of comparative example 5 is that the 84%, total effective rate of comparative example 6 is 88%.Knot
Fruit shows that moisture-keeping composition three compounding effect of the synergy with anti-anaphylaxis desensitization of the invention is safe to the human body nontoxic, right
It is notable into allergic skin therapeutic effect that is rubescent, itching in skin.
In sum, the product ratio that the embodiment 1 of moisture-keeping composition of the present invention is provided is in Sodium Hyaluronate, the de- second of carboxymethyl
The moisturizing energy of the product of any one-component and addition both components any is added in acyl chitin, dendrobium candidum extract three
Power is more longlasting, repair is stronger, can more play excellent effect, with the barrier action for repairing skin well, Neng Gouyou
The phenomenons such as effect alleviation is itched, red, swollen, hot, pain, lift the resistance of skin, lubricate skin flexible, reach one well
Various dimensions are acted on, with market popularization value higher.
Claims (10)
1. a kind of moisture-keeping composition, it is characterised in that comprising following component by weight：
Sodium Hyaluronate 1.0-5.0 parts
Carboxymethylchitosan 2.0-10.0 parts
30.0-60.0 parts of dendrobium candidum extract
Deionized water 25.0-67.0 parts.
2. moisture-keeping composition according to claim 1, it is characterised in that the carboxymethylchitosan is from ocean
The chitin polysaccharide that is extracted in biology is first chemically modified to obtain through carboxymethylated again through deacetylated.
3. moisture-keeping composition according to claim 1, it is characterised in that dendrobium candidum is more in the dendrobium candidum extract
Sugared content is 0.3-0.5%.
4. the preparation method of moisture-keeping composition according to claim 1, it is characterised in that comprise the following steps：
（1）By in Sodium Hyaluronate addition deionized water, heating for dissolving is uniform；
（2）After cooling, carboxymethylchitosan and the dissolving of dendrobium candidum extract is added to stir, you can.
5. the preparation method of moisture-keeping composition according to claim 4, it is characterised in that step（1）In be heated to 80-85
℃。
6. the preparation method of moisture-keeping composition according to claim 4, it is characterised in that step（2）In be cooled to 40-45
℃。
7. the application of moisture-keeping composition according to claim 1, it is characterised in that the moisture-keeping composition is applied to skin care
In product.
8. the application of moisture-keeping composition according to claim 7, it is characterised in that the skin care item are essence lotion, moisturizing
Frost, toner, facial mask, eye cream, stoste, mildy wash, emulsion, emulsifiable paste, hydrosol, sun screen or BB frost.
9. the application of the moisture-keeping composition according to claim 7 or 8, it is characterised in that the skin care item include：By weight
Than meter, moisture-keeping composition 5.0-10.0%, the cosmetic base 72.0-90.0% and cosmetic 0.02- of claim 1
20.0%。
10. the application of moisture-keeping composition according to claim 9, it is characterised in that the cosmetic includes surface
Activating agent, essence and flavoring agent, colouring agent, NMF, skin conditioning agent, antioxidant, preservative, sun-screening agent, thickener, pH are adjusted
One or more mixture in section agent；The cosmetic base includes oiliness class, powder class or solvent matrix.
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