CN103585053A - Dendrobium-extract-containing composition and preparation method thereof - Google Patents

Dendrobium-extract-containing composition and preparation method thereof Download PDF

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CN103585053A
CN103585053A CN201310530200.3A CN201310530200A CN103585053A CN 103585053 A CN103585053 A CN 103585053A CN 201310530200 A CN201310530200 A CN 201310530200A CN 103585053 A CN103585053 A CN 103585053A
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herba dendrobii
extract
dendrobii extract
water
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CN103585053B (en
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孟铁钢
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GUANGZHOU Q-MAX COSMETICS Co Ltd
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GUANGZHOU Q-MAX COSMETICS Co Ltd
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Abstract

The invention relates to a dendrobium-extract-containing composition, and the dendrobium-extract-containing composition can improve the problems of skin roughness, dryness and the like caused by skin water shortage, and can effectively resist oxidation and prevent aging. The dendrobium-extract-containing composition comprises the following components: a dendrobium extract, hydrogenated lecithin and plant sterol. The dendrobium extract is prepared by solvent extraction, and a solvent is selected from the group consisting of water, methanol, ethanol, isopropanol, n-butanol, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,3-butanediol, acetone, ethyl acetate, or a combination thereof. The dendrobium-extract-containing composition can well promote expression of keratinocyte AQP3 (3th aquaporin) and enhance the penetration capability of cells, and at the same time has good water locking and moisturizing effects due to the synergistic effect of the various components. The invention also includes a preparation method of the composition, the preparation method has the advantages of simple process and low cost, and a produced product has excellent quality.

Description

A kind of composition and method of making the same containing Herba Dendrobii extract
Technical field
The present invention relates to cosmetic field, specifically, the present invention relates to for skin moisture-keeping lock water, anti-aging a kind of lock water composition of the moisturizing containing Herba Dendrobii extract and the preparation thereof of antioxidation.
Background technology
People in high pressure and fast pace life, because the long-term daily schedule is irregular, diet is unhealthy and stress is large and be subject in the situations such as long-term radiation, easily make the metabolism of skin be affected skin moisture-keeping mechanism is sustained damage, thereby easily dehydration causes pachylosis, dry.
Skin is consisted of epidermis, corium and subcutaneus adipose tissue, and every layer all contains moisture.Modern study shows, having its source in of skin hydropenia: the water supply ability of the moisture retention structure of epidermal keratinocyte and activity and skin corium cell self constantly weakens, the moisture circulating function of the water albumen passage of epidermis cell is lost gradually, sebum film loses phylactic power defensive power, be unfavorable for that moisture infiltrates, epidermal keratinocyte structure is damaged, and skin corium cell cannot normal circulation moisturizing, causes skin hydropenia dry.
The scientist Peter A Gelei of U.S. Univ Johns Hopkins Med has found the aquaporin of skin, on aquaporin, there is a kind of aquaporin (Aquaporin), have another name called aquaporin, a kind of protein (inherent memebrane protein) being positioned on cell membrane, on cell membrane, form in " duct ", controlled controlling the water circulation, in the turnover of cell, similarly is " the side Pu of cell ".Aquaporin transportation moisture has critical effect, and it absorbs transmission moisture continually just as the sponge structure of skin, and can pass through 3,000,000,000 hydrones each second.Foreign scholar studies discovery, the barrier repair function of the glycerol transport function of the third aquaporin (AQP3) to the moisturizing of skin (hydration), elasticity and after damaging plays critical effect, and shows that glycerol is the determiner of horny layer water conservation and biological synthetic functional.
Some modern studies are set forth to some extent to the effect of polysaccharide component in recent years, the height water absorption of polysaccharide and good film property are perfectly in conjunction with reaching good moistening effect, vegetable polysaccharides is also applied to skin moisture-keeping just gradually, and polysaccharide is the contained main component of most Chinese herbal medicine, these have all indicated direction for finding skin moisturizer safely and effectively.
Summary of the invention
The pachylosis causing in order to solve skin dehydration, the skin injury such as dry, the invention provides a kind of in containing the compositions of Herba Dendrobii extract, the present invention simultaneously also provides a kind of preparation method of the compositions containing Herba Dendrobii extract.
For addressing the above problem, the technical solution adopted in the present invention is as follows:
A kind of compositions containing Herba Dendrobii extract, contain following component: Herba Dendrobii extract, described Herba Dendrobii extract makes through solvent extraction, described solvent is selected from water, methanol, ethanol, isopropyl alcohol, n-butyl alcohol, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination; Hydrolecithin and plant sterol.
Through the Herba Dendrobii extract of above-mentioned solvent extraction, in the middle of contain dendrobium polysaccharide, dendrobium polysaccharide, by the powerful combination of hydrogen bond and water, pins moisture, thereby reaches moistening effect.Dendrobium polysaccharide is as regulatory factor, by promoting the third aquaporin of keratinocyte AQP3() gene expression, make it synthetic more AQP3, increase the penetrating power of cell membrane, strengthen Water Cycle mobile, thereby maintain the moisturizing state of cell membrane.
Hydrolecithin: well-known, phospholipid is extensively distributed in animal and plant body, is the important composition composition of biological cell, and it plays very important effect to the infiltration of metabolism and film.Yet, because the main component of natural phospholipid is unsaturated fatty acid, so resistance to oxidation not, also unstable to heat, be difficult to be applied to cosmetics, for this problem, we obtain by natural soybean phospholipid hydrogenation the hydrolecithin that stability is high, can be widely used in cosmetics.Hydrolecithin is to extract from Semen sojae atricolor, is a kind of naturally occurring emulsifying agent with anti-inflammatory effect.There is following effect: A, can effectively reduce stimulation, reduce the potential stimulus of other surfactants, and the antiphlogistic effects that strengthens oil-soluble active matter; B, have efficient moisture retention, the protection function of strengthening skin, for the metabolism of Skin Cell film provides material; C, horny layer is had to good affinity, efficient soft effect, is improved effect to dry skin; D, phospholipid are natural grease plastid, can promote the absorption of skin to effective ingredient, improve the utilization of effective ingredient.
Plant sterol is the material that a class chemical constitution is close with cholesterol, and they are by the synthetic active component of plant tissue self.Plant sterol is commonly used for Skin Cell promoter, Wound-healing agent, and stanol ester has moisture retention, and has good resistance to oxidation, can rebuild sebum protection and repair skin barrier, is therefore widely used as among cosmetics.There is following effect: A, short infiltration: plant sterol has very high permeability to skin, can keep skin surface moisture, promote skin metabolism, suppress scytitis, can anti-day erythema, skin aging, also have the effect of hair growth promoting, hair care; B, wound healing: can promote wound healing, make muscle hypertrophy, strengthen blood capillary circulation; C, moisture retention: its good control water characteristic makes it have outstanding moisture-keeping function; D, antioxidation: plant sterol has good antioxidant.
Therefore the compositions that contains Herba Dendrobii extract, plant sterol and hydrolecithin can be good at promoting the third aquaporin of keratinocyte AQP3() expression, strengthen the penetrating power of cell, each component has produced synergism together simultaneously, moistening effect than independent a kind of compositions of or two kinds of these components is good, has good lock water, moisture-keeping function.
By a large amount of tests, show, the quality percentage composition of described Herba Dendrobii extract is that the quality percentage composition of 0.001-5%, described hydrolecithin is that the quality percentage composition of 0.001-5%, described plant sterol is that 0.001-5% is optimum proportioning, surplus is adjuvant, and the effect of the moisturizing reaching, lock water is the strongest.
In order better to reach lock water, moistening effect, described compositions also comprises adjuvant, described adjuvant comprises water adjuvant, oil phase adjuvant and nertralizer, and described water adjuvant is one or two or more kinds the combination in deionized water, glycerol, carbomer, hyaluronate sodium, methyl hydroxybenzoate; Described oil phase adjuvant is one or more combination in silicone oil, isononyl isononanoate, cetearyl alcohol, cetearyl heteroside; Described nertralizer is the combination of a kind of in triethanolamine and phenoxyethanol or two kinds.
Wherein, carbomer is the very important rheology control agent of a class, and the carbomer after neutralization is outstanding gel-type vehicle, has the important use such as thickening, suspension; Glycerol, has good water absorption, and moisturizing effect is very good; Hyaluronate sodium itself is one of formation of human body skin, is the glutinous sugar of the widest a kind of acidity that distributes in human body, is present in the substrate of connective tissue, has good moisture-keeping function; Methyl hydroxybenzoate, has antisepsis; Silicone oil has the compatibility of height in cosmetics with many components, reduce the sticky sense of product, and have certain moisture pick-up properties; Isononyl isononanoate, has unique many methyl branches structure, silk-like feeling, and dry and comfortable and extremely soft feel, has the effect of skin smoothing; Cetearyl alcohol or cetearyl heteroside, have inhibition greasy feeling, reduces wax class raw material stickiness, the effects such as stable cosmetic gel; Triethanolamine is a kind of emulsifying agent, by the cream products of triethanolamine emulsifying, there is mastic exquisiteness, the feature of mastic brilliant white, the gel phase good stability that another triethanolamine and higher fatty acids or high fatty alcohol form, constant product quality, can hold additional composition proportion high.Triethanolamine is the most frequently used nertralizer that contains the acid high-molecular gels such as carbomer, and triethanolamine, by neutralizing with carboxyls such as carbomers, forms stable macromolecular structure, reaches the effect of thickening and moisturizing; Phenoxyethanol, has biocidal efficacies, as antiseptic, uses.
In order better to make above-mentioned composition can act on skin, play good lock water, moistening effect, the described compositions containing Herba Dendrobii extract is preferably made cream or unguentum.Cream or unguentum, directly be applied on skin, can make active component Herba Dendrobii extract, plant sterol and hydrolecithin wherein directly act on epidermis cell, the good hygroscopicity of the compositions such as glycerol in compositions can strengthen the moisture of skin simultaneously, cetearyl alcohol or cetearyl heteroside possess the effect of skin smoothing simultaneously, the people that make to smear said composition can't feel the greasy feeling of other similar cosmetics, have good skin moistening, moisturizing, salubrious and comfortable function.
A kind of preparation containing the compositions cream of Herba Dendrobii extract or the preparation method of unguentum, comprise the steps: that a. prepares water: by deionized water, glycerol, hydrolecithin, carbomer, hyaluronate sodium and methyl hydroxybenzoate mix and blend, preferably mix and be warming up to 75-85 degree Celsius; B. prepare oil phase: by silicone oil, isononyl isononanoate, cetearyl alcohol and/or cetearyl heteroside, plant sterol mix and blend, preferably stir and be warming up to 75-85 degree Celsius; C. described oil phase is added to water, stir, preferably, mixing speed is 2800-3200 rev/min, and mixing time is 8-13 minute, and is incubated 18-23 minute; D adds triethanolamine, stirs, and preferably mixes and is cooled to 38-42 degree Celsius; E. add Herba Dendrobii extract and phenoxyethanol, stir, preferably, stir and be cooled to 27-33 degree Celsius.
The invention provides a kind of compositions containing Herba Dendrobii extract, can be achieved as follows technique effect: can be good at promoting the third aquaporin of keratinocyte AQP3() expression, strengthen the penetrating power of cell, each component has produced synergism together simultaneously, has good lock water, moisture-keeping function.The present invention also provides a kind of preparation method of the compositions containing Herba Dendrobii extract, and the method is simple to operate, cost is low, and the product preparing has advantages such as feel is good, mastic is fine and smooth, brilliant white.
Below in conjunction with the specific embodiment, the present invention is described in further detail.
The specific embodiment
Embodiment mono-: a kind of compositions containing Herba Dendrobii extract, by following component, made: 1000 grams of ionized waters, 100 grams of glycerol, 4 grams of carbomers, 2 grams of hydrolecithins, 1 gram of hyaluronate sodium, 1 gram of methyl hydroxybenzoate, 50 grams of silicone oil, 30 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 6 grams of plant sterols, 4 grams of triethanolamine, through 6 grams of 5 grams of the Herba Dendrobii extracts of ethanol extraction and phenoxyethanol.
Embodiment bis-: a kind of compositions containing Herba Dendrobii extract, by following component, made: 1050 grams of ionized waters, 120 grams of glycerol, 6 grams of carbomers, 6 grams of hydrolecithins, 1.5 grams of hyaluronate sodiums, 1.3 grams of methyl hydroxybenzoate, 46 grams of silicone oil, 32 grams of isononyl isononanoates, 9 grams of cetearyl alcohol, 3 grams of plant sterols, 5 grams of triethanolamine, through 7 grams of 1.3 grams of the Herba Dendrobii extracts of methanol extraction and phenoxyethanol.
Embodiment tri-: a kind of compositions containing Herba Dendrobii extract, by following component, made: 900 grams of ionized waters, 98 grams of glycerol, 5 grams of carbomers, 5 grams of hydrolecithins, 2 grams of hyaluronate sodiums, 1.5 grams of methyl hydroxybenzoate, 40 grams of silicone oil, 35 grams of isononyl isononanoates, 7 grams of cetearyl alcohol, 1.5 grams of plant sterols, 3 grams of triethanolamine, 5 grams of 3 grams of Herba Dendrobii extracts that extract through 1,3-PD and phenoxyethanol.
Embodiment tetra-: a kind of compositions containing Herba Dendrobii extract, by following component, made: 950 grams of ionized waters, 102 grams of glycerol, 3 grams of carbomers, 1 gram of hydrolecithin, 2.5 grams of hyaluronate sodiums, 1 gram of methyl hydroxybenzoate, 47 grams of silicone oil, 28 grams of isononyl isononanoates, 6 grams of cetearyl alcohol, 4 grams of plant sterols, 3.5 grams of triethanolamine, through 5 grams of 4 grams of the Herba Dendrobii extracts of acetone extraction and phenoxyethanol.
Embodiment five: take respectively 1000 grams of deionized waters, and 100 grams of glycerol, 4 grams of carbomers, 2 grams of hydrolecithins, 1 gram of hyaluronate sodium, 1 gram of methyl hydroxybenzoate, is warming up to 75 degrees Celsius by above-mentioned article mix and blend, makes water standby; Weigh respectively 50 grams of silicone oil, 30 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 5 grams of plant sterols, are warming up to 80 degrees Celsius by above-mentioned article mix and blend, make oil phase standby; Oil phase is added to water, said mixture is stirred, mixing speed is 3100 revs/min, and mixing time is 13 minutes, and is incubated 22 minutes; Add 4 grams of triethanolamine, stir and be cooled to 38 degrees Celsius; Then, then add 5 grams of Herba Dendrobii extracts through ethanol extraction and 6 grams of phenoxyethanol, stir, be cooled to 30 degrees Celsius, obtain.
Embodiment six: take respectively 1100 grams of deionized waters, and 150 grams of glycerol, 4 grams of carbomers, 4 grams of hydrolecithins, 1 gram of hyaluronate sodium, 1 gram of methyl hydroxybenzoate, is warming up to 85 degrees Celsius by above-mentioned article mix and blend, makes water standby; Weigh respectively 50 grams of silicone oil, 30 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 6 grams of plant sterols, are warming up to 85 degrees Celsius by above-mentioned article mix and blend, make oil phase standby; Oil phase is added to water, said mixture is stirred, mixing speed is 2900 revs/min, and mixing time is 10 minutes, and is incubated 19 minutes; Add 5 grams of triethanolamine, stir and be cooled to 40 degrees Celsius; Then, then add 1.5 grams of Herba Dendrobii extracts through water extraction and 7 grams of phenoxyethanol, stir, be cooled to 29 degrees Celsius, obtain.
Embodiment seven: take respectively 900 grams of deionized waters, and 95 grams of glycerol, 3 grams of carbomers, 1.5 grams of hydrolecithins, 1 gram of hyaluronate sodium, 2 grams of methyl hydroxybenzoate, are warming up to 80 degrees Celsius by above-mentioned article mix and blend, make water standby; Weigh respectively 60 grams of silicone oil, 30 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 4 grams of plant sterols, are warming up to 73 degrees Celsius by above-mentioned article mix and blend, make oil phase standby; Oil phase is added to water, said mixture is stirred, mixing speed is 2000 revs/min, and mixing time is 8 minutes, and is incubated 23 minutes; Add 4 grams of triethanolamine, stir and be cooled to 42 degrees Celsius; Then, then add 5 grams of Herba Dendrobii extracts through isopropanol extraction and 6 grams of phenoxyethanol, stir, be cooled to 32 degrees Celsius, obtain.
Embodiment eight: take respectively 980 grams of deionized waters, and 100 grams of glycerol, 3 grams of carbomers, 5 grams of hydrolecithins, 1 gram of hyaluronate sodium, 1 gram of methyl hydroxybenzoate, is warming up to 82 degrees Celsius by above-mentioned article mix and blend, makes water standby; Weigh respectively 50 grams of silicone oil, 30 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 3 grams of plant sterols, are warming up to 75 degrees Celsius by above-mentioned article mix and blend, make oil phase standby; Oil phase is added to water, said mixture is stirred, mixing speed is 3200 revs/min, and mixing time is 12 minutes, and is incubated 20 minutes; Add 4 grams of triethanolamine, stir and be cooled to 39 degrees Celsius; Then, then add 1.5 grams of Herba Dendrobii extracts through n-butanol extraction and 6 grams of phenoxyethanol, stir, be cooled to 27 degrees Celsius, obtain.
Embodiment nine: take respectively 1050 grams of deionized waters, and 100 grams of glycerol, 4 grams of carbomers, 3 grams of hydrolecithins, 1.5 grams of hyaluronate sodiums, 1 gram of methyl hydroxybenzoate, is warming up to 78 degrees Celsius by above-mentioned article mix and blend, makes water standby; Weigh respectively 50 grams of silicone oil, 34 grams of isononyl isononanoates, 8 grams of cetearyl alcohol, 4.2 grams of plant sterols, are warming up to 82 degrees Celsius by above-mentioned article mix and blend, make oil phase standby; Oil phase is added to water, said mixture is stirred, mixing speed is 2800 revs/min, and mixing time is 9 minutes, and is incubated 18 minutes; Add 4 grams of triethanolamine, stir and be cooled to 41 degrees Celsius; Then, then add 3.8 grams of Herba Dendrobii extracts through ethylene glycol extraction and 6 grams of phenoxyethanol, stir, be cooled to 33 degrees Celsius, obtain.
Embodiment ten: the compositions unguentum containing Herba Dendrobii extract that adopts embodiment five methods to prepare, and test moisturizing, lock water effect:
According to moisturizing Related Mechanism, utilize the in-vitro evaluation method of cell platform, at epidermis cell, in dry environment Xia, study group compound, help cell to resist dry, prevent dehydration, maintain the ability of the original form of cell.
It is first group that the compositions unguentum containing Herba Dendrobii extract that adopts embodiment five methods to prepare is compiled, by according to embodiment five proportionings and method but to remove that unguentum that Herba Dendrobii extract makes compiles be second group, by according to embodiment five proportionings and method but to remove that unguentum that hydrolecithin component makes compiles be the 3rd group, by according to embodiment five proportionings and method but to remove that unguentum that plant sterol component makes compiles be the 3rd group, by according to embodiment five but the unguentum of removing Herba Dendrobii extract, hydrolecithin and plant sterol component to compile be the 5th group, will.Get and respectively organize unguentum 0.1g, add MEM (Minimum Essential Media) culture fluid 9.9ml, preparation is into about the solution of 1% concentration, the normal MEM liquid cultured cells of take is blank group, under the drying condition giving in the external world, the time of test cell from normally experiencing to dry (state significant change) respectively, test result is as following table:
? Resist drying time (second) Difference Percentage ratio
Blank group 720 ? ?
First group 860 140 19.44%
Second group 830 110 15.28%
The 3rd group 810 90 12.50%
The 4th group 800 80 11.11%
The 5th group 790 70 9.72%
As can be seen from the above table, embodiment five effects of adding Herba Dendrobii extract, hydrolecithin and plant sterol component are better than effect a kind of in simple interpolation Herba Dendrobii extract, hydrolecithin and plant sterol component, can find out, three kinds of components have synergism each other, have promoted moisturizing, the lock water function of compositions.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, the variation of any unsubstantiality that those skilled in the art does on basis of the present invention and replacement all belong to the present invention's scope required for protection.

Claims (10)

1. the compositions containing Herba Dendrobii extract, it is characterized in that containing following component: Herba Dendrobii extract, described Herba Dendrobii extract makes through solvent extraction, described solvent is selected from water, methanol, ethanol, isopropyl alcohol, n-butyl alcohol, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination; Hydrolecithin and plant sterol.
2. the compositions containing Herba Dendrobii extract according to claim 1, is characterized in that: the quality percentage composition of described Herba Dendrobii extract is 0.001-5%; The quality percentage composition of described hydrolecithin is 0.001-5%; The quality percentage composition of described plant sterol is 0.001-5%; Surplus is adjuvant.
3. the compositions containing Herba Dendrobii extract according to claim 2, it is characterized in that: described adjuvant comprises water adjuvant, oil phase adjuvant and nertralizer, described water adjuvant is one or two or more kinds the combination in deionized water, glycerol, carbomer, hyaluronate sodium, methyl hydroxybenzoate; Described oil phase adjuvant is one or more combination in silicone oil, isononyl isononanoate, cetearyl alcohol, cetearyl heteroside; Described nertralizer is the combination of a kind of in triethanolamine and phenoxyethanol or two kinds.
4. the compositions containing Herba Dendrobii extract according to claim 3, is characterized in that: the described compositions containing Herba Dendrobii extract is cream or unguentum.
5. prepare a preparation method that contains as claimed in claim 4 the compositions of Herba Dendrobii extract, it is characterized in that comprising the steps: that a. prepares water: by deionized water, glycerol, hydrolecithin, carbomer, hyaluronate sodium and methyl hydroxybenzoate mix and blend; B. prepare oil phase: by silicone oil, isononyl isononanoate, cetearyl alcohol and/or cetearyl heteroside, plant sterol mix and blend; C. described oil phase is added to water, stir; D adds triethanolamine, stirs; E. add Herba Dendrobii extract and phenoxyethanol, stir.
6. preparation method according to claim 5, is characterized in that: described a step stirs and is warming up to 75-85 degree Celsius.
7. preparation method according to claim 6, is characterized in that: described b step stirs and is warming up to 75-85 degree Celsius.
8. preparation method according to claim 7, is characterized in that: the mixing speed of described c step is 2800-3200 rev/min, and mixing time is 8-13 minute, and is incubated 18-23 minute.
9. preparation method according to claim 8, is characterized in that: described d step stirs and is cooled to 38-42 degree Celsius.
10. preparation method according to claim 9, is characterized in that: described e step stirs and is cooled to 27-33 degree Celsius.
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CN106727164A (en) * 2017-02-16 2017-05-31 中山卡丝生物科技有限公司 A kind of moisture-keeping composition and its preparation method and application
CN107157872A (en) * 2017-05-08 2017-09-15 宁波易中禾生物技术有限公司 A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof
CN107823031A (en) * 2017-10-20 2018-03-23 植然方适(杭州)健康科技有限公司 A kind of fresh dendrobium candidum stem-leaf extract with antioxidation activity and moisture-keeping efficacy and preparation method thereof and applied in skin care item
CN109260109A (en) * 2018-11-14 2019-01-25 赣州市七道皇文化发展有限公司 A kind of natural perfume material facial treatment essence liquid and preparation method thereof
CN110101618A (en) * 2019-05-29 2019-08-09 尚赫(天津)科技开发有限公司 Using the moisture-keeping composition of 4XMoisLock quadruple molecular layer water lock technology
CN110302080A (en) * 2019-07-24 2019-10-08 汉义生物科技(北京)有限公司 Hemp compounds Herba Dendrobii extract and its preparation method and application

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Cited By (10)

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Publication number Priority date Publication date Assignee Title
CN104116675A (en) * 2014-07-23 2014-10-29 浙江森宇实业有限公司 Dendrobium candidum skin moisturizer and preparation method thereof
CN105853289A (en) * 2016-05-05 2016-08-17 广州丹奇日用化工厂有限公司 Cosmetic composition containing dendrobium extract and application of cosmetic composition
CN106727164A (en) * 2017-02-16 2017-05-31 中山卡丝生物科技有限公司 A kind of moisture-keeping composition and its preparation method and application
CN106727164B (en) * 2017-02-16 2018-02-23 中山卡丝生物科技有限公司 A kind of moisture-keeping composition and its preparation method and application
CN107157872A (en) * 2017-05-08 2017-09-15 宁波易中禾生物技术有限公司 A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof
CN107157872B (en) * 2017-05-08 2019-11-22 宁波易中禾生物技术有限公司 A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof
CN107823031A (en) * 2017-10-20 2018-03-23 植然方适(杭州)健康科技有限公司 A kind of fresh dendrobium candidum stem-leaf extract with antioxidation activity and moisture-keeping efficacy and preparation method thereof and applied in skin care item
CN109260109A (en) * 2018-11-14 2019-01-25 赣州市七道皇文化发展有限公司 A kind of natural perfume material facial treatment essence liquid and preparation method thereof
CN110101618A (en) * 2019-05-29 2019-08-09 尚赫(天津)科技开发有限公司 Using the moisture-keeping composition of 4XMoisLock quadruple molecular layer water lock technology
CN110302080A (en) * 2019-07-24 2019-10-08 汉义生物科技(北京)有限公司 Hemp compounds Herba Dendrobii extract and its preparation method and application

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