CN105796461A - Moisturizing and repairing lotion containing hydrolyzed pearl essence flexible nano-liposomes and sea buckthron oil - Google Patents
Moisturizing and repairing lotion containing hydrolyzed pearl essence flexible nano-liposomes and sea buckthron oil Download PDFInfo
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- CN105796461A CN105796461A CN201610162513.1A CN201610162513A CN105796461A CN 105796461 A CN105796461 A CN 105796461A CN 201610162513 A CN201610162513 A CN 201610162513A CN 105796461 A CN105796461 A CN 105796461A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
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- Gerontology & Geriatric Medicine (AREA)
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Abstract
The invention provides a moisturizing and repairing lotion containing hydrolyzed pearl essence flexible nano-liposomes and sea buckthron oil. The lotion is prepared through emulsification and homogenizing of hydrolyzed pearl essence flexible nano-liposomes, sea buckthron oil, hyaluronic acid, an emulgator, a moisturizing agent, a stabilizer and deionized water. The lotion can effectively enhance the metabolism of skin epithelial cells and dermis and repair skin, and flexible nano-liposomes can penetrate through the human skin surface easily to make pearl essence fused with cells so as to become effective. Sea buckthron oil and hyaluronic acid which have great moisturizing and repairing functions are also added, and can moisturize keratinocytes deeply and improve the elasticity of skin dermis through intense hydration, the resistance of skin is improved, skin is tightened, and fine wrinkles are reduced. The lotion is natural, mild and nearly free of irritation, is suitable for long-term use so as to achieve skin barrier repairing, moisturize skin and make skin younger, has good moisturizing and repairing effects on dry skin and sensitive skin, and can effectively whiten skin and resist wrinkles and aging.
Description
Technical field
The invention belongs to cosmetic product technical field, relate to a kind of skin care item, particularly relate to a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes and repair breast, it is a kind of can solve the problem that skin is intensely dark, flexibility decrease, dry aging problem, the liposome skin care item that moisturizing repairing effect is good.
Background technology
Skin is made up of epidermis, corium, subcutaneous fat and appendages.Epidermal area is the outermost one layer of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and keratinocyte layer.Skin appendages includes hair, hair follicle, sebaceous gland and sweat gland.Skin absorbs external substance mainly through three approach, i.e. horny layer, pilosebaceous unit and sweat duct mouth.Its mesocuticle is the most important approach of skin absorption, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in daily life, most skin care milks are aqueous solutions, Margarita powder isoreactivity material is all water miscible, and the endogenous lipid of the exogenous lipid of horny layer secretion and sebaceous gland lipid secretion is oily matter, and water soluble nutrients chance oiliness lipid is insoluble, the water-soluble skin care product utilization rate thus resulting in routine is only small, use water-soluble skin care product for a long time, easily cause nutritional labeling waste and also easily block pore.
Pharmaceutical carrier lipid physical ability wetting surface skin, makes horny layer imbibition；Have an effect with keratodermatitis, change its ordered arrangement, make skin surface form reversible little space, medicine or drug-loaded liposome in moment and enter into deep skin (skin corium) by these spaces, thus being absorbed by organisms；With the sebaceous gland of skin surface, hair follicle, sweat gland mouth effect, make medicine or drug-loaded liposome arrive deep skin by these ducts, skin permeation of drugs had obvious facilitation.Flexible nano-liposomes particle diameter is little, height self-deformation, efficiently through the skin duct of several times less of himself, some macromolecular substances being difficult to transdermal can be made to be successfully entered skin, circulate even into body, the Cutaneous permeation of medicine is had significant facilitation.Flexible nano-liposomes can change the physicochemical property of proto-drug simultaneously, strengthens pharmacological action and the curative effect of medicine, improves bioavailability, be a kind of novel carrier for transdermal delivery.
Margarita is acknowledged as cosmetic good merchantable brand always, and its beauty treatment mechanism is to contain aminoacid and the trace element of various needed by human body in Margarita, and needed for the nutritional labeling contained in Margarita and mankind's skin, nutrient is close, is easy to be absorbed by the body, has the effect of whitening, speckle dispelling.The effective ingredient utilizing Margarita in current cosmetics mainly carries out with the form of hydrolyzed pearl powder, owing to Margarita containing various trace elements, electrical conductivity is higher, such as direct interpolation, it is easy to destroy the system of cosmetics, and be directly appended in cosmetics by Margarita hydrolyzed solution its effective ingredient and be easy to by other component breakage in cosmetics so that it is lose activity and be difficult to be absorbed by the body.Hydrolyzed pearl powder is prepared into flexible nano-liposomes; the destruction to cosmetics series can be reduced; and can effectively protect the effective ingredient of Margarita not destroyed by other components in cosmetics; and the active substance of Margarita can be carried to the deep skin of human body by this hydrolyzed pearl powder flexible nano-liposomes; improve bioavailability, reach better aesthetic health care effect.
Oleum Hippophae is the complex of multivitamin and bioactive substance.Its VC content occupy one cut fruit, first of vegetable, it is described as " king of VC ", VC is kind of a natural internal whitening agent, can effectively suppress the deposition of abnormal pigment on skin and the activity of tryrosinase, and help the reduction of dopachrome (tyrosine transforms into melanic intermediate), formed thus reducing melanin, effectively clean white muscle skin, and collagenation in epithelial tissue can be promoted, increase the immunologic function of skin；Contained VE can eliminate free radical and resist Oxidation, keeps the unsaturated fatty acid in cell not oxidized when light, heat radiation；Contained carotene can be converted into VA, and then eliminates epithelial tissue keratinization or abnormal rough.Its multivitamin contained and multiple unsaturated fatty acid synergism, re-epithelilization can be promoted, it is obviously improved skin epidermal cells circulatory function, repairs skin and promote the microcirculation of capillary of skin, it is suppressed that the carrying out of lipid peroxidation, improve metabolism, delay skin aging process, can keep the sour environment of skin, has the effect of antiallergic, bactericidal antiphlogistic, and there is stronger saturating property, it is a kind of desirably natural skin care product raw material.
Summary of the invention
For overcoming the shortcoming existing for prior art, it is an object of the invention to provide a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes and repair breast, it is with liposome for carrier, nutritional labeling is carried to deep skin, utilization is fully absorbed by human body, these skin care item can solve the problem that skin is intensely dark, flexibility decrease, dry aging problem, and moisturizing repairing effect is good.
For realizing described goal of the invention, breast is repaired in Oleum Hippophae moisturizing provided by the invention, it is made up of by weight percentage following component: hydrolyzed pearl powder flexible nano-liposomes 2-15%, Oleum Hippophae 5-15%, hyaluronic acid 0.2-2%, emulsifying agent 5-20%, wetting agent 10-20%, stabilizer 1-20%, surplus is deionized water, and the percentage composition sum of each component is 100%.
Described hydrolyzed pearl powder flexible nano-liposomes, mainly contains soybean lecithin, sodium cholate, hydrolyzed pearl powder, and particle diameter is at 10nm-100nm.
One or more in PEG40 stearate, PEG60 castor oil hydrogenated, Tween 80, Polyethylene Glycol (300) monoleate, Macrogol 4000, branched fatty acid ester and Fatty acid macrogolglycerides of described emulsifying agent.
Described wetting agent is one or more in vaseline and lanoline.
Described stabilizer is one or more in glycerol, spermol (cetyl alcohol), propylene glycol and butanediol.
The preparation method that it is a further object to provide described hydrolyzed pearl powder flexible nano-liposomes, is realized by following steps:
(1) quantitatively weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add isotonic phosphate buffer liquid (pH7.4), Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form hydrolyzed pearl powder flexible lipidosome suspension；
(5) liposome turbid liquor is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain hydrolyzed pearl powder flexible nano-liposomes.
It is also another object of the present invention to provide the preparation method that breast is repaired in the described Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes, realized by following steps:
(1) weighing Oleum Hippophae and the oil phase dispensing such as emulsifying agent, wetting agent of formula ratio, stirring mixes, and heating obtains homogeneous oil phase compound to 75-85 DEG C；
(2) weighing stabilizer and the deionized water of formula ratio, heating is to 75-85 DEG C, and mix homogeneously obtains aqueous phase compound；
(3) oil phase compound is added in whipping process aqueous phase compound, emulsifying it；
(4), after being cooled to 50 DEG C, hydrolyzed pearl powder flexible nano-liposomes, hyaluronic acid are added, homogeneous；
(5) being cooled to 35 DEG C, finished product is packed to obtain in discharging.
The present invention utilizes the several amino acids contained in hydrolyzed pearl powder and the nutrient substance such as trace element, polypeptide, prepares Oleum Hippophae moisturizing and repairs breast, can effectively strengthen the metabolism of skin epidermal cells and corium, repair the function of skin.Flexible nano-liposomes average diameter is 100 nanometers, is the 1/200～1/300 of human body cell diameter, can penetrate human body skin top layer easily, makes Margarita powder and cell fusion, plays effect；Be aided with there is the Oleum Hippophae of stronger moisturizing repair, hyaluronic acid acts on skin, can go deep into humidifying keratinocyte and powerful hydration to improve the elasticity of dermis of skin, strengthen skin resistance, compact skin, desalinates microgroove.Product of the present invention is natural, gentle, almost without stimulation, it is possible to the long-term use for skin barrier reparation, skin moistening moisturizing and skin rejuvenation.Dry skin quality, sensitive skin quality etc. are had good replenishing water and preserving moisture repairing effect, and can effectively clean white muscle skin, crease-resistant anti-aging.
Detailed description of the invention
Below in conjunction with detailed description of the invention, principles of the invention and feature being described, example is served only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1
Hydrolyzed pearl powder flexible nano-liposomes forms:
Soybean lecithin 5.5wt%
Sodium cholate 1.5wt%
Hydrolyzed pearl powder 1.5wt%.
The preparation method of hydrolyzed pearl powder flexible nano-liposomes, is realized by following steps:
(1) quantitatively weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add isotonic phosphate buffer liquid (pH7.4), Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form hydrolyzed pearl powder flexible lipidosome suspension；
(5) liposome turbid liquor is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain hydrolyzed pearl powder flexible nano-liposomes.
Breast is repaired in Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes
Oil phase composition:
The stirring of above-mentioned oil phase dispensing being mixed, heating obtains homogeneous oil phase compound to 75 DEG C；In whipping process, add the deionized water of 60wt%75 DEG C, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add 4wt% hydrolyzed pearl powder flexible nano-liposomes (embodiment 1) and 0.2wt% hyaluronic acid, homogeneous, being cooled to 35 DEG C, finished product is packed to obtain in discharging.
Embodiment 2
Oil phase composition:
Oleum Hippophae 15wt%
Tween 80 10wt%
Vaseline 10wt%
The stirring of above-mentioned oil phase dispensing being mixed, heating obtains homogeneous oil phase compound to 75 DEG C；In whipping process, add the deionized water of 10wt% glycerol and 42wt%75 DEG C, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add 13wt% hydrolyzed pearl powder flexible nano-liposomes (embodiment 1) and 0.2wt% hyaluronic acid, homogeneous, being cooled to 35 DEG C, finished product is packed to obtain in discharging.
Describe the component of the present invention, preparation method and the effect reached above in association with embodiment in detail, but embodiment illustrates the present invention with being only for demonstration.Description is only for explaining claims.But protection scope of the present invention is not limited to description.Any those familiar with the art in the technical scope of present disclosure, the change that can readily occur in or replacement, all should be encompassed within protection scope of the present invention.
Embodiment 3 effect detection
Being participated in using moisturizing of the present invention to repair breast from the women of the various skin types of 20 to 60 years old by 80 ages, every women is previously every average daily uses that there is prestige or at least one natural or organic skin care products of medicine cosmetic board.Wherein 50 participants are sensitive skin, are defined as presently, there are such as flushing heating, tight sense, desquamation or acneform lesion.Participant's morning and evening every day face after the cleaning uses the present composition, substitutes conventional skin-protection product.After using surrounding, participant completes questionnaire.Result of study is in Table 1.
Table 1
Participant all admits this product to no skin irritation, substantially feels skin comfort, softness after using, and without greasy feeling, has obvious sun-proof whitening effect, and sunburn is had good reparation effect, reduces the skin lesion cicatrix of acne.
Embodiment 4 effect detection
Test is divided into invention group, matched group and blank group, and invention group uses embodiment 1 to prepare the skin care item of gained.
Oleum Hippophae in the skin moistening product of the matched group plant society oils and fats without embodiment 1, other component, content and preparation method thereof are identical with embodiment 1.
The skin moistening product of blank group are without the Oleum Hippophae in embodiment 1 and hyaluronic acid, and other component, content and preparation method thereof are identical with embodiment 1.
Randomly select 90 bit test persons, be randomly divided into 3 groups, often organize 30 people, test at December.3 groups be divided into smear the skin moistening product of invention group, matched group and blank group respectively, and every day respectively smears once sooner or later, after using surrounding, observe respectively and often organize in tester for the obvious number of the efficiently individual quantity preventing xerosis cutis from chapping and effect, and result is referring to table 2.
Table 2 prevents xerosis cutis from chapping measure of merit result
| Efficiently individual quantity | The obvious number of effect | Effective percentage | The obvious rate of effect | |
| Blank group | 6 | 1 | 20% | 3.33% |
| Matched group | 18 | 14 | 60% | 46.67% |
| Invention group | 27 | 21 | 90% | 70% |
Be can be seen that by upper table 2, skin moistening product of the present invention contain Oleum Hippophae and the hyaluronic acid of special ratios simultaneously, interact between the two collaborative, with containing only having in Oleum Hippophae and hyaluronic acid compared with any one matched group, the skin moistening product of invention group are chapped the raising of highly significant to preventing xerosis cutis.
Claims (7)
1. breast is repaired in the Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes, it is characterized in that, it is made up of by weight percentage following component: hydrolyzed pearl powder flexible nano-liposomes 2-15%, Oleum Hippophae 5-15%, hyaluronic acid 0.2-2%, emulsifying agent 5-20%, wetting agent 10-20%, stabilizer 1-20%, surplus is deionized water, and the percentage composition sum of each component is 100%.
2. breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterized in that, described hydrolyzed pearl powder flexible nano-liposomes, is made up of soybean lecithin, sodium cholate, hydrolyzed pearl powder, and particle diameter is at 10nm-100nm.
3. breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterized in that, one or more in PEG40 stearate, PEG60 castor oil hydrogenated, Tween 80, Polyethylene Glycol (300) monoleate, Macrogol 4000, branched fatty acid ester and Fatty acid macrogolglycerides of described emulsifying agent.
4. breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterised in that described wetting agent is one or more in vaseline and lanoline.
5. breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterised in that described stabilizer is one or more in glycerol, spermol, propylene glycol and butanediol.
6. breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1 and 2, it is characterised in that described hydrolyzed pearl powder flexible nano-liposomes is prepared by method and obtains:
(1) quantitatively weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add the isotonic phosphate buffer liquid of pH7.4, Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form hydrolyzed pearl powder flexible lipidosome suspension；
(5) liposome turbid liquor is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain hydrolyzed pearl powder flexible nano-liposomes.
7. the preparation method that breast is repaired in a kind of Oleum Hippophae moisturizing containing hydrolyzed pearl powder flexible nano-liposomes described in claim 1, it is characterised in that realized by following steps:
(1) taking oil phase dispensing Oleum Hippophae and emulsifying agent, wetting agent, stirring mixing, heating obtains homogeneous oil phase compound to 75-85 DEG C；
(2) taking stabilizer and deionized water, heating is to 75-85 DEG C, and mix homogeneously obtains aqueous phase compound；
(3) oil phase compound is added in whipping process aqueous phase compound, emulsifying；
(4), after being cooled to 50 DEG C, hydrolyzed pearl powder flexible nano-liposomes, hyaluronic acid are added, homogeneous；
(5) being cooled to 35 DEG C, finished product is packed to obtain in discharging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162513.1A CN105796461A (en) | 2016-03-21 | 2016-03-21 | Moisturizing and repairing lotion containing hydrolyzed pearl essence flexible nano-liposomes and sea buckthron oil |
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| CN201610162513.1A CN105796461A (en) | 2016-03-21 | 2016-03-21 | Moisturizing and repairing lotion containing hydrolyzed pearl essence flexible nano-liposomes and sea buckthron oil |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106913588A (en) * | 2017-03-27 | 2017-07-04 | 北海市宝珠林海洋科技有限公司 | A kind of externally applied drug of the infantile eczema of treated powder containing pearl |
| CN106924163A (en) * | 2017-03-27 | 2017-07-07 | 北海市宝珠林海洋科技有限公司 | A kind of reparation liquid containing hydrolysis pearl composition |
| CN113143792A (en) * | 2021-03-23 | 2021-07-23 | 杭州帝通生物科技有限公司 | Moisturizing repair cream for repairing skin barrier and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913588A (en) * | 2017-03-27 | 2017-07-04 | 北海市宝珠林海洋科技有限公司 | A kind of externally applied drug of the infantile eczema of treated powder containing pearl |
| CN106924163A (en) * | 2017-03-27 | 2017-07-07 | 北海市宝珠林海洋科技有限公司 | A kind of reparation liquid containing hydrolysis pearl composition |
| CN113143792A (en) * | 2021-03-23 | 2021-07-23 | 杭州帝通生物科技有限公司 | Moisturizing repair cream for repairing skin barrier and preparation method thereof |
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Application publication date: 20160727 |