CN105902408B - Cosmetic composition containing brown alga and red algae essence - Google Patents
Cosmetic composition containing brown alga and red algae essence Download PDFInfo
- Publication number
- CN105902408B CN105902408B CN201510621942.6A CN201510621942A CN105902408B CN 105902408 B CN105902408 B CN 105902408B CN 201510621942 A CN201510621942 A CN 201510621942A CN 105902408 B CN105902408 B CN 105902408B
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- China
- Prior art keywords
- oligosaccharide
- cosmetic composition
- red algae
- alginate
- alginate oligosaccharide
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- 150000008131 glucosides Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000010468 hazelnut oil Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 229940116978 human epidermal growth factor Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940100573 methylpropanediol Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000011295 pitch Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- LUPNKHXLFSSUGS-UHFFFAOYSA-M sodium;2,2-dichloroacetate Chemical compound [Na+].[O-]C(=O)C(Cl)Cl LUPNKHXLFSSUGS-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/12—Face or body powders for grooming, adorning or absorbing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to the cosmetic compositions containing brown alga and red algae essence.Specifically, the cosmetic composition contains alginate oligosaccharide and red algae oligosaccharide the present invention relates to a kind of cosmetic composition.The invention also includes a kind of methods of moistening effect for improving cosmetic composition, and the method includes alginate oligosaccharide and red algae oligosaccharide are added into the cosmetic composition.Cosmetic composition of the invention not only has the function of moisture-keeping function (to skin surface) thering is excellent skin-friendly, can provide the effect of the second pipe skin to skin；But also have the function of restructuration (to deep skin), that is, it can increase the epidermis hyaluronic acid contents of epidermis deep layer；The synthesis of tight junction protein 1 is activated, intercellular close connection is enhanced；Increase the synthesis of ceramide, improves lipid barrier.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to the cosmetic composition containing brown alga and red algae essence.
Background technique
Moist and elasticity and the moisture in skin of skin have substantial connection, when the moisture in skin is excessively lost, meeting
Cause to have dry skin, follow the string, accelerated ageing.Therefore one of the effect of moisture absorption, moisturizing are always skin protection cosmetics.Preferably
Moisturizer should have good wettability power, and moisture-keeping functions are persistently stablized.
Natural polysaccharide is with a wide range of applications on cosmetics.Such as it is chitin, algal polysaccharide, antler glue, viscous
Polysaccharide, fucoidin etc. have nutrition, reparation and moisturizing and other effects.The moisturizing of polysaccharide material, moisture absorption mechanism are due in molecule
Containing a large amount of hydrophilic radical, a large amount of moisture can be combined at hydrogen bond with associated water molecules, and glycan molecule is interweaved in net
Shape forms thin film on surface, plays water retention.And after polysaccharide is degraded to oligosaccharide, with the fracture of glycosidic bond, greatly
The free hydroxyl group of amount is released, and the ability of bound water molecule can enhance, in addition, when due to molecular breakdown, molecular structure
Become loose condition (of surface), is more advantageous to the close of hydrone.Therefore, oligosaccharide often has more excellent moisture pick-up properties, but oligomeric
The moisture retention of sugar is because the partial destruction of reticular structure can be weakened.
Natural polysaccharide or oligosaccharide are isolated from algae.According to color classification, algae is divided into cyanobacteria, red algae, green alga and brown
Algae.Many algae have been used as a part of cosmetics for health & beauty.
For example, CN200780039713.7 discloses a kind of ocean oligosaccharide and biofermentation object in cosmetics,
It include Sarcodiotheca oligosaccharide and the acceptable excipient of cosmetics more particularly to a kind of cosmetic composition.
S.gaudichaudii is medium-sized to large-scale flaccid red alga species, has cylindrical frangible frond；Color can be yellowish
Color changes between pale pink color, peony or rufous.Once harvest, can be by well known by persons skilled in the art any
Extracting method produces the oligosaccharide of Sarcodiotheca, and preferred oligosaccharide is the aqueous oligomeric of the whole plants from dehydration
Sugar.
CN201110341261.6 discloses a kind of water-replenishing repairing cosmetic and its preparation method and application, the moisturizing reparation
Cosmetics, including freeze-dried powder is repaired in moisturizing and basic liquid is repaired in moisturizing, the freeze-dried powder is by as follows according to mass percentage
Group is grouped as: grape pip oligosaccharide 0.1%~2%, hydrolyzes red algae oligosaccharide 0.5%~4%, small-molecular-weight hyaluronic acid
0.05%~1%, Hydrolyzed Collagen 1%~5%, recombinant human horny cell growth factor-2 0.00001%~0.001%, weight
Group human epidermal growth factor 0.00001%~0.001%, low molecular sodium heparin 0.01%~0.2%, stabilizer 1%~
15% surplus is injection stage water；The basic liquid is grouped as by the group as follows based on gross mass percentage: hyaluronic acid
0.01%~0.4%, methyl propanediol 0.5%~4%, honey oligosaccharide 0.5%~5%, Anjidew NL50 0.5%~5%, dissolution
Proteinase-10 .5%~5%, 1,2 hexylene glycol 0.3%~0.7%, oat beta glucan 1.5%~6%, isoflavones 1%~
5%, surplus is deionized water or water for injection.
There is still a need for a kind of cosmetic compositions for not only having moisture-keeping function but also have restructuration.
Summary of the invention
The present invention provides a kind of cosmetic composition, which not only has moisture-keeping function (to skin surface
Effect), that is, have excellent skin-friendly (alginate oligosaccharide), can to skin provide the second pipe skin effect；But also have
There is restructuration (to deep skin), that is, can increase the epidermis hyaluronic acid contents of epidermis deep layer；The close connection of activation
The synthesis of albumen 1 enhances intercellular close connection；Increase the synthesis of ceramide, improves lipid barrier.
Cosmetic composition of the invention contains alginate oligosaccharide and red algae oligosaccharide.
In a specific embodiment, with total restatement of cosmetic composition, the cosmetic composition contains 0.5~
3% alginate oligosaccharide and 0.5~3% red algae oligosaccharide.
In a specific embodiment, with total restatement of cosmetic composition, the cosmetic composition contains 0.5~
2% alginate oligosaccharide and 0.5~2% red algae oligosaccharide.
In a specific embodiment, with total restatement of cosmetic composition, the cosmetic composition contains 0.5~
1.5% alginate oligosaccharide and 0.5~1.5% red algae oligosaccharide.
In a specific embodiment, with total restatement of cosmetic composition, the cosmetic composition contains 1.0%
Alginate oligosaccharide and 1.0% red algae oligosaccharide.
In a specific embodiment, the weight ratio of alginate oligosaccharide and red algae oligosaccharide is 1:5 in cosmetic composition
To 5:1.
In a specific embodiment, the weight ratio of alginate oligosaccharide and red algae oligosaccharide is 1:3 in cosmetic composition
To 3:1.
In a specific embodiment, the weight ratio of alginate oligosaccharide and red algae oligosaccharide is 1:1 in cosmetic composition.
In a specific embodiment, the alginate oligosaccharide has a structure that
In a specific embodiment, the red algae oligosaccharide has a structure that
The invention also includes a kind of methods of moistening effect for improving cosmetic composition, and the method includes to the makeup
Alginate oligosaccharide and red algae oligosaccharide are added in product composition.
In a specific embodiment, the total restatement of cosmetics after alginate oligosaccharide and red algae oligosaccharide is added, it is
0.5~3%, the content of red algae oligosaccharide is 0.5~3%；Preferably, the content of alginate oligosaccharide is 0.5~2%, and red algae is low
The content of glycan is 0.5~2%；It is highly preferred that the content of alginate oligosaccharide is 0.5~1.5%, the content of red algae oligosaccharide is
0.5~1.5%.
In a specific embodiment, with 1:5 to 5:1, preferably 1:3 to 3:1, the ratio of more preferable 1:1 are oligomeric by brown alga
Sugar and red algae oligosaccharide are added in the cosmetic composition.
In a specific embodiment, the cosmetic composition is toner, lotion, face cream, face cleaning class product, shield
Skin essence, eye-care, sunscreen product or powder adornment class product.
Detailed description of the invention
Fig. 1 show through desiccation stress handle 1 hour after, changing value (the relatively untreated skin of % of skin moisture-keeping level
Skin).It is from left to right followed successively by blank group, alginate oligosaccharide: red algae oligosaccharide=1:3, alginate oligosaccharide: red algae oligosaccharide=3:
1 and alginate oligosaccharide: red algae oligosaccharide=1:1 changing value.
Fig. 2 show through desiccation stress handle 16 hours after, changing value (the relatively untreated skin of % of skin moisture-keeping level
Skin).It is from left to right followed successively by blank group, alginate oligosaccharide: red algae oligosaccharide=1:3, alginate oligosaccharide: red algae oligosaccharide=3:
1 and alginate oligosaccharide: red algae oligosaccharide=1:1 changing value.
Fig. 3 shows that deep-sea of the present invention moisturizes the moisture-keeping efficacy of double algae essence.
Fig. 4 shows that compared with single algae deep-sea more of the present invention moisturizes the instant and lasting moisture-keeping function of double algae essence.From a left side to
The right side is successively blank group, alginate oligosaccharide+red algae oligosaccharide of 1:1,1% alginate oligosaccharide and 1% red algae oligosaccharide
Effect.
Specific embodiment
The present invention provides a kind of cosmetic composition, which contains alginate oligosaccharide and red algae oligosaccharide.
The present invention also provides a kind of methods of moistening effect for improving cosmetic composition, and this method includes adding into cosmetic composition
Add alginate oligosaccharide and red algae oligosaccharide.
Alginate oligosaccharide
Alginate oligosaccharide refers to the oligosaccharide for extracting from brown alga.
There is effect immediately for alginate oligosaccharide of the invention, it can be in cuticula immediately in conjunction with water；Accumulation effect
Fruit, i.e. use daily can make epidermis moisture retention water is flat to significantly improve；And continue moistening effect, epidermis can be rebuild, it is permanent to have
Continue moisturizing effect.
Alginate oligosaccharide is suitable for the invention to usually contain with flowering structure:
Techniques known in the art means can be used and prepare alginate oligosaccharide from marine brown.For example, enzymatic can be used
Depolymerization preparation.In this method, enzyme is the alginate lyase of marine microorganism secretion.The enzyme can help to decompose brown alga
(chelorella) alginic acid (macromolecule brown alga biological polyoses) in, final degradation form small molecule alginate oligosaccharide.About
It, herein will be complete disclosed in it reference can be made to 6207438 B1 of US using the technology of the alginic acid in alginate lyase depolymerization brown alga
Portion's content is included in herein by reference.Commercially available alginate oligosaccharide can also be used, for example, the production of codif company can be used
Alginate oligosaccharide product.
The molecular weight of alginate oligosaccharide is suitable for the invention usually in the range of 120~250kDa, such as 130~
200kDa, 130~180kDa etc..In a specific embodiment, the molecular weight of alginate oligosaccharide is about 150kDa, example
Such as, 150 ± 10kDa.
In cosmetic composition of the present invention, with total restatement of cosmetic composition, usually contain 0.5~3% brown alga it is low
Glycan preferably comprises 0.5~2.0% alginate oligosaccharide, further preferably 0.5~1.5% alginate oligosaccharide.Have at one
In body embodiment, in cosmetic composition of the present invention containing 1.0% alginate oligosaccharide.
Red algae oligosaccharide
Red algae oligosaccharide refers to the oligosaccharide for extracting from red algae.
It is a kind of epidermis hyaluronic acid activator for red algae oligosaccharide of the invention, epidermis hyaluronic acid can be promoted
Synthesis；It can reinforce the close connection of epidermis, reduce TEWL；With the synthesis that can promote ceramide.Experimental data shows:
Red algae has extraordinary restructuration from basal layer to cuticular layer, to entire epidermis.
Can be used and be originated from Northern Europe polar region --- the worm in Scandinavia sea area pitches red algae (Fucellaria
Lumbrilicalis, also name kylin algae, petrel nest) extract red algae oligosaccharide of the invention.By the red of depolymerization Sulfation
Algae powder obtains red algae oligosaccharide, is rich in galactolipin and Anhydrogalactose.
In general, removing water drying after obtaining red algae, obtaining red algae powder.In anhydrous conditions, using supercritical CO2Technology
The red algae powder of Sulfation is passed through in hydrolysis.It can be obtained red algae oligosaccharide after depolymerization.Red algae oligosaccharide can be placed in
Again aquation in 0.05% sea salt solution.Using 0.05% sea salt solution rehydration red algae oligosaccharide powder, sea salt solution
In the potassium element that is rich in, can induce polymer and form double-spiral structure, the characteristic of its hyaluronic acid is assigned with this.It is consequently formed
Red algae the molecular weight of oligosaccharide is typically larger than 100kDa, such as in the range of 100~250kDa, such as 150~250kDa, 180~
220kDa etc..In a specific embodiment, the molecular weight of red algae oligosaccharide is about 200kDa, such as 200 ± 10kDa.Meanwhile
Preferably, red algae oligosaccharide includes with flowering structure:
Such as supercritical CO described in WO 01/28649 can be used2Technology extracts red algae oligosaccharide of the invention, herein
The full content of this article is included in herein by reference.Alternatively, the red algae oligosaccharide of codif company production can be used to produce
Product.
In cosmetic composition of the present invention, with total restatement of cosmetic composition, usually contain 0.5~3% red algae it is low
Glycan preferably comprises 0.5~2.0% red algae oligosaccharide, further preferably 0.5~1.5% red algae oligosaccharide.Have at one
In body embodiment, in cosmetic composition of the present invention containing 1.0% red algae oligosaccharide.
Additive
In addition to constituting the deionized water of most of weight of cosmetic composition of the present invention, cosmetic composition of the invention
It can also include a variety of additives used in cosmetic field.CTFA Cosmetic Ingredient Dictionary (CTFA Cosmetic
Ingredient Handbook) the conventional use of nonlimiting cosmetic ingredient of a large amount of those skilled in the art is described, they
It is suitble to use in cosmetic composition of the invention.The example of this kind of component type includes but is not limited to: preservative, grinding
Agent, emulsifier, emollient, absorbent, gelling agent, antifoaming agent, buffer, colorant, filmogen, pH adjusting agent, wetting agent,
Skin conditioning agent, thickener, aromatic and pigment.
For example, this kind of additive includes:
(1) solid and wax material, as petroleum, lanolin, ceresine, microwax, Brazil wax, C10-C30 fatty acid,
With C10-C30 alcohols material etc.；
(2) oily substance, such as olive oil, jojoba oil, castor oil, sunflower oil, hazelnut oil, shea butter and safflower oil
Deng；
(3) viscosity modifier/stabilizer, such as guar gum, xanthan gum, carrageenan, hydroxyethyl cellulose, fungi plant
Glue, carbomer glue, polyacrylate and acrylate-C10-C30 alkyl acrylate copolymer etc.；
(4) hydrophily moisturizer, such as glycerol, propylene glycol, butanediol, sodium lactate, Anjidew NL50 etc.；
(5) emollient, such as isononyl isononanoate, carbonic acid dioctyl ester, cetanol ethylhexoate, glycerol three (thylhexoic acid)
Ester, dicaprylyl ether, myristyl myristate, the caprate of C10-C30, the glycerol containing sad and/or capric acid C10-C30
Three esters and the glyceride of C10-C30 etc.；
(6) assistant for emulsifying agent, such as hexadecanol, octadecanol, 16 octadecanols, tristerin, stearic acid, second two
Alcohol glyceride, bi-tristearin etc.；
(7) emulsifier, including nonionic surface active agent and anionic surfactant, the anionic surface are living
Salt, the olive oil of property the agent such as salt containing 2-Lauroyloxypropionic acid, the salt of Caproyllactic acid, the salt of cocounut oil acyl lactic acid, stearoyl lactylates
The salt of spermaceti alcohol ester, the salt of olive oil D-sorbite or salt of glyceryl oleate citrate etc., these salt it is typical sun from
Attached bag includes sodium ion, potassium ion, ammonium ion, calcium ion and magnesium ion etc.；The non-ionic surfactants such as fatty acid
Polyoxyethylene ester, sorbitan ester, sucrose ester, alkyl glycosides, glycerol citrate and polyglycereol lipid etc.；
(8) silicone oil substance；
(9) colorant, such as it is inorganic auxiliary with object and inorganic dyestuff；
(10) preservative, such as Phenoxyethanol and parabens；
(11) pH adjusting agent, such as sodium hydroxide, potassium hydroxide and triethanolamine.
(12) aromatic, such as all kinds of essential oils and compound essence；Etc..
Based on the overall effect for wishing that cosmetic composition generates through the invention, cosmetic composition of the invention may be used also
To use other cosmetic active ingredients, such as: Anti-acne actives (such as: salicylic acid or benzoyl peroxide), crease-resistant
Active matter (such as: retinoids or β-hydroxy acid), antioxidant (such as: ascorbic acid and its derivative or tealeaves oligosaccharide),
Chelating agent (such as: EDETATE SODIUM), anti-inflammatory agent (such as: corticosteroid), anoretic (such as: caffeine), skin lightening agent
(such as: mulberry fruit oligosaccharide or kojic acid) or sun-screening agent (such as: the commercially available product of entitled PARSOL).
Composition of the invention is generally prepared by the conventional method known in the art for preparing cosmetic composition.This
Class method relates generally to blending constituent in one or more steps, becomes relatively uniform state, wherein be with or without heating,
Cooling uses vacuum etc..Composition can be any conventional form, such as gel, emulsifiable paste, lotion or wash-off type product.
The amount of additive is also the conventional amount used of this field.
Cosmetic composition
As previously mentioned, cosmetic composition of the present invention contains alginate oligosaccharide and red algae oligosaccharide.With cosmetic composition
Total restatement, usually contain 0.5~3% alginate oligosaccharide, preferably comprise 0.5~2.0% alginate oligosaccharide, more preferably contain
Have 0.5~1.5% alginate oligosaccharide and 0.5~3% red algae oligosaccharide, preferably comprise 0.5~2.0% red algae it is oligomeric
Sugar, further preferably 0.5~1.5% red algae oligosaccharide.
In general, in cosmetic composition, the weight ratio of alginate oligosaccharide and red algae oligosaccharide 1:5 to 5:1 range it
It is interior, preferably 1:3 to 3:1, more preferable 1:1.
For example, containing 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1% in cosmetic composition respectively
Or 1.2% equal proportion alginate oligosaccharide and red algae oligosaccharide.
Therefore, in a preferred embodiment of the invention, cosmetic composition contain about 1.0% alginate oligosaccharide and
About 1.0% red algae oligosaccharide.
As previously mentioned, techniques known in the art means can be used to be extracted from brown alga and red algae for cosmetics of the present invention
Alginate oligosaccharide and red algae oligosaccharide.Or commercially available product can also be used to prepare cosmetic composition of the invention.City
The example for selling product includes that the deep-sea PHEONOV of codif company production moisturizes double algae essence.
The example of cosmetic composition of the present invention includes toner, lotion, face cream, face cleaning class product, facial treatment essence, eye
Portion's nursing, sunscreen product and powder adornment class product etc..
In a specific embodiment, cosmetic composition of the present invention in addition to containing alginate oligosaccharide and red algae oligosaccharide with
And water, it can also contain hydrophily moisturizer (such as glycerol and butanediol), viscosity modifier (such as carbomer), preservative (such as euxyl
K350), pH adjusting agent (such as triethanolamine), aromatic and chelating agent (such as edta salt, such as EDETATE SODIUM).In general, with makeup
Total restatement of product composition, the content of hydrophily moisturizer are 2~20%, and the content of viscosity modifier is 0.05~0.5%, are prevented
The content of rotten agent is 0.1~0.5%, and the content of pH adjusting agent is 0.05~0.5%, the content of aromatic is 0.01~
0.5%, the content of chelating agent is 0.01~0.05%.
In a specific embodiment, the hydrophily moisturizer in cosmetic composition of the invention is glycerol and fourth two
Alcohol, with total restatement of cosmetic composition, the content of glycerol is 2~10%, and the content of butanediol is 2~8%.
Different cosmetic compositions contains different additives.For example, toner is except low containing brown alga of the invention
Glycan and red algae oligosaccharide be outer and water, can also be containing hydrophily moisturizer (such as glycerol, butanediol), viscosity modifier (as blocked
Wave nurse), preservative (such as euxyl K350), pH adjusting agent (such as triethanolamine), aromatic, oily substance (such as PEG-60 hydrogenation
Castor oil) and chelating agent (such as EDETATE SODIUM)；Lotion can also contain hydrophily moisturizer (such as glycerol and butanediol), emollient
(such as caprylic/capric triglyceride, isononyl isononanoate and cetostearyl alcohol), silicone oil, nonionic surfactant (such as spermaceti
Stearyl glucoside), viscosity modifier (such as carbomer), preservative, pH adjusting agent (such as triethanolamine), aromatic, chelating agent
(such as EDETATE SODIUM)；Face cream can also contain hydrophily moisturizer (such as glycerol, butanediol), emollient (such as carbonic acid dioctyl ester, whale
Wax stearyl alcohol ethylhexoate, glycerol three (thylhexoic acid) ester, cetostearyl alcohol), silicone oil, anionic surfactant it is (such as sweet
Oil-stearic acid citrate), viscosity modifier (such as carbomer), preservative, pH adjusting agent (such as triethanolamine), aromatic and chela
Mixture (such as EDETATE SODIUM).The dosage of these additives is the conventional amount used of this field.
The method that this field routine can be used prepares cosmetics of the present invention, such as by being simply uniformly mixed each ingredient
?.Alternatively, as shown in the embodiment of the present application, for different cosmetic compositions, first by different components in different condition
Under be mixed into different mixtures, then these mixtures are mixed again.These are all slapped in those skilled in the art
Within the technical scope held.
It should be understood that the sum of total amount percentage of all components should be equal to 100% in composition.
The method for improving the moistening effect of cosmetic composition
Alginate oligosaccharide and red algae oligosaccharide can be added into existing cosmetic composition, to improve the cosmetics group
Close the moistening effect of object.Existing cosmetic composition includes but is not limited to toner, lotion, face cream, face cleaning class product, shield
Skin essence, eye-care, sunscreen product and powder adornment class product etc., ingredient includes but is not limited to previously described various composition.
In general, to be added to total restatement of the cosmetic composition after alginate oligosaccharide and alginate oligosaccharide, brown alga is oligomeric
The content of sugar is 0.5~3.0%, preferably 0.5~2.0%, more preferable 0.5~1.5%；The content of red algae oligosaccharide be 0.5~
3.0%, preferably 0.5~2.0%, more preferable 0.5~1.5%.In terms of the adding proportion of two kinds of oligosaccharide, alginate oligosaccharide and red
The adding proportion of algae oligosaccharide is usually 1:5~5:1, preferably 1:3~3:1, more preferably 1:1.For example, specific real at one
It applies in example, after adding alginate oligosaccharide and red algae oligosaccharide, containing respective content be about 0.5% in cosmetic composition,
0.6%, the alginate oligosaccharide of 0.7%, 0.8%, 0.9%, 1.0%, 1.1% or 1.2% equal proportion and red algae oligosaccharide.
Compared with being not added with the comparison cosmetic composition of alginate oligosaccharide and red algae oligosaccharide, under the conditions of same test,
The moistening effect of cosmetic composition of the present invention will improve 10% or more, and for example, at least 20%, preferably at least 30%, at least
40%, at least 50% etc..
Conventional method can be used alginate oligosaccharide and red algae oligosaccharide are added in cosmetic composition.
The present invention will be described in a manner of specific embodiment below.It should be understood that these embodiments are only illustrative, and
Unrestricted protection scope of the present invention.Alginate oligosaccharide and red algae oligosaccharide used are obtained from the production of codif company in embodiment
Product, remaining ingredient can be obtained from commercially available approach.
Embodiment: the preparation of cosmetic composition of the present invention
The formula of according to the form below 1-3 prepares toner, lotion and face cream.
Table 1: toner formula
| The number of phases | Ingredient | Content (weight percent) |
| A | Water | It is added to 100% |
| A | Glycerol | 5% |
| A | Butanediol | 5% |
| A | Carbopol | 0.1% |
| A | EDETATE SODIUM | 0.02% |
| B | Triethanolamine | 0.1% |
| C | Alginate oligosaccharide | 0.5% |
| C | Red algae oligosaccharide | 1% |
| C | Essence | 0.05% |
| C | PEG-60 rilanit special | 0.2% |
| C | Preservative euxyl K350 | 0.3% |
Preparation method:
(1) A phase material mixing dispersing and dissolving is uniform, it is heated to 70 DEG C；
(2) triethanolamine is added when stirring is cooled to 50 DEG C, stirring neutralizes；
(3) C phase substance is added when stirring is cooled to 45 DEG C, stirs evenly.
Table 2: emulsion formulations
| The number of phases | Ingredient | Content (weight percent) |
| A | Water | It is added to 100% |
| A | Glycerol | 6% |
| A | Butanediol | 3% |
| A | EDETATE SODIUM | 0.02% |
| A | Carbomer981 | 0.1% |
| B | Caprylic/capric triglyceride | 5% |
| B | Isononyl isononanoate | 3% |
| B | Silicone oil | 1% |
| B | Cetostearyl alcohol | 0.5% |
| B | Cetearyl glucoside | 1.5% |
| C | Triethanolamine | 0.1% |
| D | euxyl K350 | 0.3% |
| D | Essence | 0.1% |
| D | Alginate oligosaccharide | 2% |
| D | Red algae oligosaccharide | 1% |
Preparation method:
(1) A phase material mixing dispersing and dissolving is uniform, it is heated to 75 DEG C；
(2) by B phase material mixing, 75 DEG C are heated to；
(3) B phase substance addition A phase is emulsified, and used homogenizer homogeneous 3 minutes；
(4) triethanolamine is added after emulsifying, uses homogenizer homogeneous 1 minute；
(5) D phase substance is added when stirring is cooled to 45 DEG C, uses homogenizer homogeneous 1 minute.
Table 3: face cream
| The number of phases | Ingredient | Content (weight percent) |
| A | Water | It is added to 100% |
| A | Glycerol | 6% |
| A | Butanediol | 4% |
| A | Carbopol | 0.2% |
| A | EDETATE SODIUM | 0.02% |
| A | Carbonic acid dioctyl ester | 4% |
| B | Cetostearyl alcohol ethylhexoate | 3% |
| B | Glycerol three (thylhexoic acid) ester | 2% |
| B | Silicone oil | 1% |
| B | Cetostearyl alcohol | 2% |
| B | Glyceryl stearate citrate | 2.5% |
| C | Triethanolamine | 0.2% |
| D | Alginate oligosaccharide | 1% |
| D | Red algae oligosaccharide | 1% |
| D | euxyl K350 | 0.3% |
| D | Essence | 0.1% |
Preparation method:
(1) A phase material mixing dispersing and dissolving is uniform, it is heated to 75 DEG C；
(2) by B phase material mixing, 75 DEG C are heated to；
(3) B phase substance addition A phase is emulsified, and used homogenizer homogeneous 3 minutes；
(4) triethanolamine is added after emulsifying, using homogenizer homogeneous 1 minute, and stirs cooling；
(5) D phase substance is added when stirring is cooled to 45 DEG C, uses homogenizer homogeneous 1 minute.
Test case
This test case use face cream shown in table 3 in embodiment (the sum of weight percent of two kinds of algae oligosaccharide for
2%) tested, only by the ratio between alginate oligosaccharide therein and red algae oligosaccharide be successively changed to 1:3,1:1 and
3:1.
1, single algae test data of different proportion
Experimental method: the serious dehydration of 2h is carried out using salt crystal to skin explant in advance, then local skin
Using with formula shown in table 3 face cream (only by the ratio between alginate oligosaccharide therein and red algae oligosaccharide according to
It is secondary to be changed to 1:3,1:1 and 3:1), it is horizontal using corneometry technical testing skin moisture-keeping, test alginate oligosaccharide and red algae
The effect of oligosaccharide ratio (1:3,1:1 and 3:1).
After desiccation stress is handled 1 hour, the changing value (the relatively untreated skin of %) of skin moisture-keeping level is shown in Fig. 1.
After desiccation stress is handled 16 hours, the changing value (the relatively untreated skin of %) of skin moisture-keeping level is shown in Fig. 2.
Fig. 1 and 2's the results show that after desiccation stress is handled 1 hour and 16 hours, using containing 2% different list algae ratios
Deep-sea moisturize double algae essence and can effectively improve the hydration levels of skin, and moistening effect is most obvious when ratio 1:1.
Test case 2: cosmetic composition moisture-keeping efficacy of the present invention
Experimental method: the serious dehydration of 2h is carried out using salt crystal to skin explant in advance, then local skin
Using the face cream (ratio between alginate oligosaccharide and red algae oligosaccharide is 1:1) with formula shown in table 3, use
Corneometry technical testing skin moisture-keeping is horizontal.
As the result is shown in Fig. 3.The results show that although deep-sea of the present invention moisturizes double algae essences by serious desiccation stress
China still can be such that at once skin is independently hydrated once again, and after moisturizing double algae essence using 2% deep-sea, inner skin moisturizing in 1 hour is horizontal
Improve 75%.
Test case 3: compared with single algae, the instant and lasting moisture-keeping function of cosmetic composition of the present invention is tested
The above experimental method is equally used, the moisturizing level of skin after 16h is tested.No. 1 is blank control group, No. 2 uses
The face cream (ratio between alginate oligosaccharide and red algae oligosaccharide is 1:1) being formulated shown in table 3, No. 3 oligomeric using 1% brown alga
Sugar, No. 4 use 1% red algae oligosaccharide oligosaccharide.
As the result is shown in Fig. 4.It is from left to right No. 1-4 moistening effect figure respectively in Fig. 4.As seen from Figure 4,
After desiccation stress 16 hours, it is more potent than the moisture-keeping function of single algae that deep-sea of the present invention moisturizes double algae essence (No. 2), has association
Same effect.
Claims (14)
1. a kind of cosmetic composition, which is characterized in that the cosmetic composition contains alginate oligosaccharide and red algae oligosaccharide；
The molecular weight of the alginate oligosaccharide is 120~250kDa, and is had a structure that
The molecular weight of the red algae oligosaccharide is 100~250kDa, and is had a structure that
With total restatement of cosmetic composition, the cosmetic composition contains 0.5~3% alginate oligosaccharide and 0.5~3%
Red algae oligosaccharide；
The weight ratio of alginate oligosaccharide and red algae oligosaccharide is 1:5 to 5:1 in the cosmetic composition.
2. cosmetic composition as described in claim 1, which is characterized in that
(1) with total restatement of cosmetic composition, the cosmetic composition contain 0.5~2% alginate oligosaccharide and 0.5~
2% red algae oligosaccharide；Or
(2) in the cosmetic composition, the weight ratio of alginate oligosaccharide and red algae oligosaccharide is 1:3 to 3:1.
3. cosmetic composition as claimed in claim 2, which is characterized in that the cosmetic composition contains 0.5~1.5%
Alginate oligosaccharide and 0.5~1.5% red algae oligosaccharide.
4. cosmetic composition as claimed in claim 2, which is characterized in that the cosmetic composition contain 1.0% it is brown
Algae oligosaccharide and 1.0% red algae oligosaccharide.
5. cosmetic composition as claimed in claim 2, which is characterized in that the weight ratio of alginate oligosaccharide and red algae oligosaccharide
For 1:1.
6. cosmetic composition as described in any one in claim 1-5, which is characterized in that the alginate oligosaccharide by using
Alginate lyase decomposes the alginic acid of brown alga and obtains, and the red algae oligosaccharide is by using supercritical CO2Technology hydrolysis warp
The Esterification red algae powder of over cure and obtain.
7. cosmetic composition as claimed in claim 6, which is characterized in that the cosmetic composition also contains selected from following
One of additive or a variety of: preservative, grinding agent, emulsifier, absorbent, gelling agent, antifoaming agent, buffer, coloring
Agent, filmogen, pH adjusting agent, wetting agent, thickener, aromatic and pigment.
8. cosmetic composition as described in claim 1, which is characterized in that the cosmetic composition be toner, lotion,
Face cream, face cleaning class product, facial treatment essence, eye-care, sun-proof or powder adornment class product.
9. a kind of method for the moistening effect for improving cosmetic composition, the method includes being added into the cosmetic composition
Alginate oligosaccharide and red algae oligosaccharide；
The molecular weight of the alginate oligosaccharide is 120~250kDa, and is had a structure that
The molecular weight of the red algae oligosaccharide is 100~250kDa, and is had a structure that
To be added the total restatement of cosmetics after alginate oligosaccharide and red algae oligosaccharide, the content of alginate oligosaccharide is 0.5~
3%, the content of red algae oligosaccharide is 0.5~3%；
Alginate oligosaccharide and red algae oligosaccharide are added in the cosmetic composition with the ratio of 1:5 to 5:1.
10. method as claimed in claim 9, which is characterized in that the method includes following characteristics:
(1) to be added the total restatement of cosmetics after alginate oligosaccharide and red algae oligosaccharide, the content of alginate oligosaccharide is 0.5~
3%, the content of red algae oligosaccharide is 0.5~3%；
(2) alginate oligosaccharide and red algae oligosaccharide are added in the cosmetic composition with the ratio of 1:5 to 5:1；
(3) cosmetic composition be toner, it is lotion, face cream, face cleaning class product, facial treatment essence, eye-care, sun-proof
Product or powder adornment class product；
(4) alginate oligosaccharide decomposes the alginic acid of brown alga by using alginate lyase and obtains, and the red algae is oligomeric
Sugar is by using supercritical CO2Technology hydrolysis is obtained by the red algae powder of Sulfation；With
(5) cosmetic composition contains one of additive selected from the following or a variety of: preservative, grinding agent, emulsification
Agent, absorbent, gelling agent, antifoaming agent, buffer, colorant, filmogen, pH adjusting agent, wetting agent, thickener, aromatic
And pigment.
11. method as claimed in claim 9, which is characterized in that the change after alginate oligosaccharide and red algae oligosaccharide is added
The total restatement of cosmetic, the content of alginate oligosaccharide are 0.5~2%, and the content of red algae oligosaccharide is 0.5~2%.
12. method as claimed in claim 9, which is characterized in that the change after alginate oligosaccharide and red algae oligosaccharide is added
The total restatement of cosmetic, the content of alginate oligosaccharide are 0.5~1.5%, and the content of red algae oligosaccharide is 0.5~1.5%.
13. method as claimed in claim 9, which is characterized in that with the ratio of 1:3 to 3:1 that alginate oligosaccharide and red algae is low
Glycan is added in the cosmetic composition.
14. method as claimed in claim 9, which is characterized in that added alginate oligosaccharide and red algae oligosaccharide with the ratio of 1:1
Into the cosmetic composition.
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| KR102631159B1 (en) * | 2016-10-21 | 2024-01-30 | 가부시키가이샤 시세이도 | Laminin 511 production promoter, basal epidermal layer stabilizer and/or screening method for agent to minimize reduction in or promote increase in epidermal stem cells |
| CN108078833B (en) * | 2017-12-11 | 2020-05-26 | 中山中研化妆品有限公司 | A kind of slimming cream and preparation method thereof |
| CN108379132A (en) * | 2018-04-11 | 2018-08-10 | 广州赛莱拉干细胞科技股份有限公司 | The composition of red algae extract is pitched based on worm and its in the application of cosmetics |
| KR102119957B1 (en) * | 2018-09-14 | 2020-06-08 | (주)더원코스메틱 | Whitening, anti-wrinkle and anti-oxidant cosmetic composition comprising the mixed extract of Gloiopeltis tenax, Dulse and Sea spaghetti as an active ingredient and preparation method of the same |
| CN112245332A (en) * | 2020-12-02 | 2021-01-22 | 青岛博智汇力生物科技有限公司 | Eczema gel containing marine oligosaccharide |
| CN112494361A (en) * | 2020-12-28 | 2021-03-16 | 青岛博智汇力生物科技有限公司 | Antibacterial and anti-radiation marine oligosaccharide isolation emulsion and preparation method thereof |
| CN112675072A (en) * | 2021-01-12 | 2021-04-20 | 南方海洋科学与工程广东省实验室(湛江) | Non-agar oligosaccharide matrix water-free hand sanitizer and preparation method thereof |
| CN114533645A (en) * | 2022-03-07 | 2022-05-27 | 广州市万千粉丝化妆品有限公司 | Application of substrate liquid of activated algae like bactosporium in skin care product and preparation method |
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Effective date of registration: 20180906 Address after: 200040 room 302-170, 9 Weihai Road, Jingan District, Shanghai, 302-170. Applicant after: Shanghai hundred deer antelope Biotechnology Co., Ltd. Address before: 200040 052, room A, 3 building, 710 Changping Road, Jingan District, Shanghai. Applicant before: Shanghai Pechoin Chemical Co., Ltd. |
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| GR01 | Patent grant |