CN110917105A - Allergy-relieving cosmetic composition and preparation method thereof - Google Patents
Allergy-relieving cosmetic composition and preparation method thereof Download PDFInfo
- Publication number
- CN110917105A CN110917105A CN201911354018.0A CN201911354018A CN110917105A CN 110917105 A CN110917105 A CN 110917105A CN 201911354018 A CN201911354018 A CN 201911354018A CN 110917105 A CN110917105 A CN 110917105A
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- allergy
- percent
- stirring
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention relates to a cosmetic composition capable of soothing allergy and a preparation method thereof, the cosmetic composition comprises purified water, an emulsifier, an emollient, a skin conditioner, a polyol, EDTA-2Na and a soothing active substance, wherein the soothing active substance is a compound of a Quercus suber bark extract and a Quercus acutissima root extract. The invention further improves the allergy-relieving effect of the cosmetic composition by utilizing a high-pressure micro-jet technology.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a allergy-relieving cosmetic composition and a preparation method thereof.
Background
With the progress of society and the improvement of living standard of people, people pay more and more attention to skin care and self image, and various cosmetics are used in large quantities. However, with the use of cosmetics in large quantities, skin diseases caused by cosmetics are also increasing in large quantities, and skin allergy is one of the most common.
The skin allergy is caused by the fact that certain ingredients in cosmetics stimulate skin cells and make the skin cells produce antibodies, thereby causing allergy. Many commercially available cosmetics are manufactured from chemical raw materials, and additives such as emulsifiers, perfumes, pigments, bactericides, preservatives and the like may cause skin damage.
Generally, although oils and fats keep the skin moist and resist external stimuli, they also prevent skin breathing, resulting in large pores and causing sebaceous gland dysfunction; certain emulsifiers can destroy the structure of skin tissue, cause skin sensitivity and have stronger carcinogenicity; the perfume often has strong allergenicity and is easy to cause anaphylactic reaction; the bactericide kills harmful bacteria and beneficial bacteria at the same time, and reduces the self-protection function of the skin; preservatives produce 100% of active oxygen and are one of the most powerful of the effects of skin aging.
The irritation of the cosmetics is related to the using effect of the cosmetics and the application prospect of the cosmetics. In order to solve the allergy problem, various allergy-relieving compositions, allergy-relieving repair liquids, and the like are disclosed in the prior art, for example:
chinese patent application CN 201810911656.7 discloses a composition for soothing the sensitive skin, which comprises 0.5-20 parts by weight of alcohol extract of silybum marianum fruit for inhibiting the production of cell inflammatory factors, 0.5-20 parts by weight of alcohol extract of holy basil for inhibiting the production of cell inflammatory factors, 15-45 parts by weight of water extract of upland cotton for improving DNA repair, and 25-40 parts by weight of alcohol extract of mushroom for moisturizing the skin and accelerating the repair of skin barrier.
Chinese patent application CN 201810278981.4 discloses a soothing and repairing composition, which comprises the following raw materials: radix astragali extract, rhizoma Atractylodis Macrocephalae extract, and cortex Albizziae extract; wherein the mass ratio of the astragalus membranaceus root extract, the bighead atractylodes rhizome extract and the albizia bark extract is (1-10): (1-10): (1-10).
Chinese patent application CN 201910495922.7 discloses an anti-inflammatory allergy-relieving repair emulsion containing Abelmoschus manihot, the formula of the emulsion is composed of group A raw materials, group B raw materials and group C raw materials, wherein the group A raw materials are composed of an emulsifier, grease, copaiba balsam resin, cocoa resin of Dahua and silicone oil, the group B raw materials are composed of deionized water, 1, 3-butanediol, hydrolyzed sodium hyaluronate, biological polysaccharide and xanthan gum, the group C raw materials are composed of an allergy-relieving composition and a preservative, and the allergy-relieving composition is composed of an Abelmoschus manihot extract, a coix seed extract, a lucid ganoderma extract and an wormwood extract.
The use of these soothing prostheses is generally a remedy to some extent after an allergy has occurred due to the use of cosmetics. It is more practical if the irritation of cosmetics can be reduced and the allergic reaction caused by the use of cosmetics can be reduced as much as possible.
Therefore, there is a need for a soothing cosmetic composition that contains soothing active ingredients, thereby reducing the irritation of allergy to other ingredients in the cosmetic.
Disclosure of Invention
The invention aims to provide a allergy-relieving cosmetic composition and a preparation method thereof.
In order to achieve the object of the present invention, in one aspect, the present invention provides a soothing cosmetic composition comprising, in weight percent, purified water and the following components:
emulsifier: 0.5 to 7.5 percent
And (3) an emollient: 2.0 to 15 percent
Skin conditioner: 0.1 to 5.0 percent
Polyol: 2.0 to 35 percent
EDTA-2Na：0.01％-0.1％
Allergy-relieving active substance: 0.2 to 20.0 percent
Wherein the desensitizing active substance is a compound of bark extract and root extract of Quercus suber L.
Preferably, the above-mentioned soothing active is a compound of oak bark extract and oak root extract extracted by supercritical extraction, wherein the solvent used is coconut oil, the soothing active has better anti-free radical activity and the function of inhibiting inflammatory factor TNF- α, thereby effectively reducing the allergic irritation of other components in the cosmetic.
In order to improve the permeability of the active ingredients in the cosmetic composition, the high-pressure micro-jet technology is utilized to disperse the active ingredients into fine emulsion with the particle size of 30-300nm, so that the transdermal effect of the active ingredients for relieving allergy is promoted. Preferably, the cosmetic composition of the present invention is dispersed into a fine emulsion having a particle size in the range of 50 to 200nm using a high pressure micro-jet technique.
As a specific embodiment of the present invention, the cosmetic composition of the present invention further comprises 0.2% to 20.0% of a whitening active, which is a complex of Glycyrrhiza glabra (Glycyrrhiza glabra L.) root extract, althea officinalis (Althaea officinalis linn.) root extract, and rice chaff extract.
Preferably, the whitening active is a mixture of pulverized plant powder extracted from vegetable oil and glyceride, such as Glycyrrhiza glabra root extract, Althea officinalis root extract, and testa oryzae extract. The extraction solvent is preferably rapeseed oil and polyglycerol-3 diisostearate. The whitening component in the liquorice is oil-soluble, and the extraction efficiency of active substances can be improved by oil phase extraction.
In the cosmetic composition, the glycyrrhiza glabra root extract, the marshmallow root extract and the rice chaff extract have complementary whitening effects and are oil-soluble natural plant whitening components.
In the embodiment of the invention, the allergy-relieving active ingredient and the oil-soluble plant whitening active ingredient are selected for compounding, so that the stimulation caused by the whitening active ingredient can be greatly relieved, the whitening active ingredient is protected, and the secretion of inflammatory factors is inhibited; meanwhile, the emulsified composition of the allergy-relieving active substance and the whitening active substance is dispersed into fine emulsion with the particle size of 30-300nm by using a high-pressure micro-jet technology, so that the transdermal effect of each active ingredient can be further promoted.
Preferably, the mass ratio of the allergy-relieving active substance to the whitening active substance is 1: 5-10: 1, more preferably between 1: 3-3: 1.
In the cosmetic composition of the present invention, although the emulsifier used is not particularly limited, it is preferable to select an emulsifier which is less irritating to human skin and is easily compounded with other ingredients in the cosmetic composition. Preferably, the emulsifier used is at least one of the group: polyglycerol-10 myristate, hydrogenated lecithin, polyglycerol-10 laurate, polyglycerol-3 diisostearate, PEG-10 soyasterol, PPG-13-decyltetradecylpolyether-24, PPG-6-decyltetradecyltetradecyltetradecylpolyether-30, sorbitan polyether-30 tetraoleate, sorbitan polyether-40 tetraoleate and sorbitan polyether-60 tetraoleate.
In the cosmetic composition of the present invention, the emollient used is not particularly limited, but is selected as far as possible from those having low irritation to human skin and is convenient for compounding with other ingredients in the cosmetic composition. Preferably, the emollient employed is at least one of the group consisting of: coconut oil, rapeseed oil, olive oil, squalane, hydrogenated polyisobutene, caprylic/capric triglyceride, canola oil, and meadowfoam seed oil.
In the cosmetic composition of the present invention, the polyol used may be at least one of the following group: glycerol, propylene glycol, 1, 3-propanediol, butanediol, pentanediol, and 1, 2-hexanediol; preferably, the polyol employed is a combination of glycerol and 1, 2-hexanediol.
In the cosmetic composition of the present invention, the skin conditioning agent employed may be tocopherol and/or tocopherol acetate.
In another aspect, to achieve the object of the present invention, the present invention also provides a method for preparing the above cosmetic composition, comprising the steps of:
(1) under the stirring state, slowly adding purified water and EDTA-2Na into a water phase cylinder in sequence, and stirring to a colorless transparent state;
(2) adding emulsifier, emollient, skin conditioner, whitening active substance and/or allergy relieving active substance into emulsifying tank under stirring, mixing, heating to dissolve the raw materials completely, and homogenizing;
(3) adding polyol into the mixture obtained in the step (2), stirring and homogenizing;
(4) after the above process is finished, slowly pumping the raw materials in the water phase cylinder into the emulsifying cylinder under the stirring state, and keeping the temperature;
(5) after the above process is finished, cooling the emulsification cylinder, continuing stirring and discharging;
(6) and (4) carrying out high-pressure micro-jet homogenization treatment on the emulsion obtained in the step (5), wherein the pressure is controlled in the range of 5000-30000PSI, and the cycle time is 1-6.
The above method may further include: and testing the particle size of the prepared emulsion, and filling the emulsion into a bottle after each index is qualified.
Preferably, in the above method, the pressure of the high-pressure microfluidization homogenization is 10000-.
Preferably, in the above method, the obtained emulsion is dispersed into a fine emulsion having a particle diameter in the range of 30 to 300nm, more preferably, into a fine emulsion having a particle diameter in the range of 50 to 200nm, during the high-pressure microfluidization homogenization treatment of step (6).
In a further aspect, to achieve the object of the present invention, the present invention also provides a cosmetic composition product comprising the above cosmetic composition and a cosmetic carrier for the cosmetic composition. That is, the cosmetic composition of the present invention may be used as it is as a finished product, or may be contained in a cosmetic vehicle.
In the cosmetic composition products described above, the cosmetic vehicle of the cosmetic composition used includes a facial mask, spray, wipe, lotion, cream, lotion, gel, or other cosmetic product for application to the skin.
When the cosmetic composition is used in the dosage forms of astringent, mask, wet tissue and the like, on one hand, the efficacy of the product can be improved, and on the other hand, the convenience of the formula can be improved.
In the invention, in order to overcome the problems in the prior art, the inventor selects and utilizes plant allergy-relieving active ingredients, has better anti-free radical activity and the effect of inhibiting inflammatory factor TNF- α, can relieve the stimulation of other active ingredients in cosmetics and ensure the activity of other active ingredients, and simultaneously uses a high-pressure micro-jet technology to disperse the emulsified cosmetic composition into fine emulsion with the particle size of 30-300nm, so as to promote the allergy-relieving active ingredients to permeate into the epidermis to play a role.
The present invention will be further described with reference to the accompanying drawings and specific embodiments, which are illustrative of certain specific embodiments of the present invention and are not to be construed as limiting the invention. It will be apparent to those skilled in the art that various modifications and variations can be made without departing from the principles of the invention, and it is also considered to be within the scope of the invention.
Drawings
Fig. 1 shows the detection results of L values based on 3D skin models of example 1 and comparative examples 1 and 2;
FIG. 2 shows the results of the melanin content test based on the 3D skin model in example 1 and comparative examples 1 and 2;
FIG. 3 shows the results of the 3D skin model-based tissue viability assay of example 1 and comparative example 1;
FIG. 4 shows the results of the 3D skin model-based detection of the inflammatory factor IL-1 α in example 1 and comparative example 1.
Detailed Description
Example 1
The raw material formulations used in example 1 and comparative examples 1 and 2 were as follows:
the specific process conditions and processes in this example are as follows:
(1) setting the temperature of the water phase tank to 85 ℃, starting stirring for 30r/min, sequentially and slowly adding the components in the group A under the stirring state, and stirring to a colorless transparent state;
(2) setting the temperature of an emulsification cylinder to be 85 ℃, starting stirring for 40r/min, adding the phase B into the emulsification cylinder, uniformly mixing, heating to 85 ℃, completely dissolving the raw materials, starting homogenizing for 3 minutes, and rotating at 2500 r/min;
(3) after the process is finished, adding 1, 2-hexanediol and glycerol in the C phase into an emulsifying tank, stirring for 5min at 40r/min, and then starting homogenizing for 3 min at the rotating speed of 3000 r/min;
(4) after the process is finished, setting an emulsification cylinder for stirring for 45r/min, slowly pumping the raw material of the water phase cylinder into the emulsification cylinder, and keeping the temperature for 5-10 min;
(5) after the process is finished, the emulsification cylinder is started to cool, the temperature is reduced to 35 ℃, stirring is continued for 15 minutes, and then discharging is carried out;
(6) treating the emulsion with high-pressure micro-jet homogenizer at pressure of 20000PSI and cycle number of 2 times;
(7) the prepared emulsion is tested for particle size, and can be filled into bottles after various indexes are qualified.
Comparative example 1
The other processes and process parameters of comparative example 1 were the same as those of example 1 except that the high-pressure microfluidizer treatment was not performed, and the raw material components used were the same.
Comparative example 2
The other raw material ingredients of comparative example 2 were the same as in example 1 except that no soothing active (coconut oil/quercus suber bark extract/quercus acutissima root extract) was added, and the process and process parameters for their preparation were the same as in example 1.
The in vitro whitening efficacy and the anti-inflammatory and anti-allergy soothing efficacy of example 1, comparative example 2 were evaluated, and the experimental results are summarized in table 1:
TABLE 1
1. Anti-inflammatory and anti-allergy efficacy assessment based on "SLS-episkutis": testing was based on a 3D skin model
The skin injury model is constructed by Sodium dodecyl sulfate (SLS) stimulation, then the skin injury model is uniformly coated on the surface of the SLS-EpiKutis skin injury model in a surface administration mode, and the skin anti-inflammatory and allergy-relieving effects of the sample to be tested are evaluated by detecting the tissue activity of the model and the release amount of an inflammatory factor IL-1 α.
The experimental result shows that after the allergy-relieving active substance is adopted, the allergy-relieving effect of the cosmetic is obvious; the formula of the micro emulsion after the high-pressure micro-jet technology is tested under the condition of keeping the same component proportion, and the allergy relieving effect is more obvious than that of the common emulsion.
2. Skin model based on 3D melanin
The evaluation of the in vitro whitening efficacy of the product: experiment with 3D melanoderm model
For the test tool, with reference to the experimental groups and the corresponding treatment conditions in Table 1, UVB irradiation treatment (50mJ/cm2) was performed every day from the day of model shipment (defined as day 0), the positive control (kojic acid) and the sample to be tested were uniformly applied to the surface of the melanin model after 3 consecutive days of stimulation, the administration volume was 10. mu.L/time,the preparation is administered 1 time every 2 days, and is administered after 4 days of continuous stimulation. And (3) carrying out L value detection on the models of different experimental groups by using a colorimeter, and carrying out melanin content detection on the models of the experimental groups.
The data show that the whitening effect is more obvious by matching the allergy-relieving active substance and the whitening active substance; the whitening effect is more obvious than that of the common emulsion by testing the fine emulsion after the high-pressure micro-jet technology under the condition of the same component proportion.
Example 2
The raw material formula and the process adopted in the example 2 are as follows:
phase A:
purifying water: 46.97 percent
EDTA-2Na：0.03％
Phase B:
PPG-6-decyltetradecanol polyether-30: 3.0 percent
Coconut oil/quercus suber bark extract/quercus acutissima root extract: 5.0 percent
Rapeseed oil/polyglycerol-3 diisostearate/glycyrrhiza glabra root extract/marshmallow root extract/rice chaff extract: 10.0 percent
White Potentilla seed oil: 2.0 percent
Tocopherol acetate: 1.0 percent
And C phase:
1, 2-hexanediol: 2.0 percent
Glycerol: 30.0 percent
The sum of the weight percentages of the raw materials is 100 percent.
The process comprises the following steps:
(1) setting the temperature of the water phase tank to 85 ℃, starting stirring for 30r/min, sequentially and slowly adding the components in the group A under the stirring state, and stirring to a colorless transparent state;
(2) setting the temperature of an emulsification cylinder to be 85 ℃, starting stirring for 40r/min, adding the phase B into the emulsification cylinder, uniformly mixing, heating to 85 ℃, completely dissolving the raw materials, starting homogenizing for 3 minutes, and rotating at 2500 r/min;
(3) after the process is finished, adding the phase C raw material into an emulsifying cylinder, stirring for 5min at 40r/min, and then starting homogenizing for 3 min at the rotating speed of 3000 r/min;
(4) after the process is finished, setting an emulsification cylinder for stirring for 45r/min, slowly pumping the raw material of the water phase cylinder into the emulsification cylinder, and keeping the temperature for 5-10 min;
(5) after the process is finished, the emulsification cylinder is started to cool, the temperature is reduced to 35 ℃, stirring is continued for 15 minutes, and then discharging is carried out;
(6) processing the emulsion by a high-pressure micro-jet homogenizer at the pressure of 15000PSI and the cycle number of 3 times;
(7) the prepared emulsion is tested for particle size, and can be filled into bottles after various indexes are qualified.
Example 3
The raw material formula and the process adopted in the example 3 are as follows:
phase A:
purifying water: 52.75 percent
EDTA-2Na：0.05％
Phase B:
polyglycerol-10 myristate: 3.0 percent
Hydrogenated lecithin: 2.0 percent
Coconut oil/quercus suber bark extract/quercus acutissima root extract: 6.0 percent
Rapeseed oil/polyglycerol-3 diisostearate/glycyrrhiza glabra root extract/marshmallow root extract/rice chaff extract: 6.0 percent
Olive fruit oil: 4.0 percent
Caprylic/capric triglyceride: 4.0 percent
Tocopherol acetate: 0.2 percent of
And C phase:
1, 2-hexanediol: 2.0 percent
Glycerol: 10.0 percent
1, 3-propanediol: 10.0 percent
The sum of the weight percentages of the raw materials is 100 percent.
The process comprises the following steps:
(1) setting the temperature of the water phase tank to 85 ℃, starting stirring for 30r/min, sequentially and slowly adding the components in the group A under the stirring state, and stirring to a colorless transparent state;
(2) setting the temperature of an emulsification cylinder to be 85 ℃, starting stirring for 40r/min, adding the phase B into the emulsification cylinder, uniformly mixing, heating to 85 ℃, completely dissolving the raw materials, starting homogenizing for 3 minutes, and rotating at 2500 r/min;
(3) after the process is finished, adding the phase C raw material into an emulsifying cylinder, stirring for 5min at 40r/min, and then starting homogenizing for 3 min at the rotating speed of 3000 r/min;
(4) after the process is finished, setting an emulsification cylinder for stirring for 45r/min, slowly pumping the raw material of the water phase cylinder into the emulsification cylinder, and keeping the temperature for 5-10 min;
(5) after the process is finished, the emulsification cylinder is started to cool, the temperature is reduced to 35 ℃, stirring is continued for 15 minutes, and then discharging is carried out;
(6) treating the emulsion with high-pressure micro-jet homogenizer at 20000PSI for 4 times;
(7) the prepared emulsion is tested for particle size, and can be filled into bottles after various indexes are qualified.
The sources of the raw materials used in the above experiments of the present invention are as follows:
Claims (10)
1. a cosmetic composition comprises, in weight percent, purified water and the following components:
emulsifier: 0.5 to 7.5 percent
And (3) an emollient: 2.0 to 15 percent
Skin conditioner: 0.1 to 5.0 percent
Polyol: 2.0 to 35 percent
EDTA-2Na：0.01％-0.1％
Allergy-relieving active substance: 0.2 to 20.0 percent
Wherein the allergy-relieving active substance is a compound of an extract of oak bark and an extract of oak root of cortex emboli.
2. The cosmetic composition according to claim 1, wherein the cosmetic composition is a fine emulsion which is homogenized by high-pressure microfluidization and dispersed to have a particle size in the range of 30 to 300 nm.
3. The cosmetic composition of claim 1, wherein the cosmetic composition further comprises 0.2% to 20% of a whitening active, wherein the whitening active is a combination of glycyrrhiza glabra root extract, marshmallow root extract and rice chaff extract.
4. The cosmetic composition according to any one of claims 1 to 3, wherein the emulsifier is at least one member selected from the group consisting of: polyglycerol-10 myristate, hydrogenated lecithin, polyglycerol-10 laurate, polyglycerol-3 diisostearate, PEG-10 soyasterol, PPG-13-decyltetradecylpolyether-24, PPG-6-decyltetradecyltetradecyltetradecylpolyether-30, sorbitan polyether-30 tetraoleate, sorbitan polyether-40 tetraoleate and sorbitan polyether-60 tetraoleate.
5. The cosmetic composition according to any one of claims 1 to 3, wherein the emollient is at least one member selected from the group consisting of: coconut oil, rapeseed oil, olive oil, squalane, hydrogenated polyisobutene, caprylic/capric triglyceride, canola oil, and meadowfoam seed oil.
6. The cosmetic composition according to any one of claims 1 to 3, wherein the polyhydric alcohol is at least one member selected from the group consisting of: glycerol, propylene glycol, 1, 3-propanediol, butanediol, pentanediol, and 1, 2-hexanediol; the skin conditioning agent is tocopherol and/or tocopherol acetate.
7. A process for preparing a cosmetic composition according to any one of claims 1 to 6, comprising the steps of:
(1) under the stirring state, slowly adding purified water and EDTA-2Na into a water phase cylinder in sequence, and stirring to a colorless transparent state;
(2) adding emulsifier, emollient, skin conditioner, whitening active substance and/or allergy relieving active substance into emulsifying tank under stirring, mixing, heating to dissolve the raw materials completely, and homogenizing;
(3) adding polyol into the mixture obtained in the step (2), stirring and homogenizing;
(4) after the above process is finished, slowly pumping the raw materials in the water phase cylinder into the emulsifying cylinder under the stirring state, and keeping the temperature;
(5) after the above process is finished, cooling the emulsification cylinder, continuing stirring and discharging;
(6) and (4) carrying out high-pressure micro-jet homogenization treatment on the emulsion obtained in the step (5), wherein the pressure is controlled in the range of 5000-30000PSI, and the cycle time is 1-6.
8. The method according to claim 7, wherein, in the high-pressure microfluidization homogenization treatment of step (6), the resulting emulsion is dispersed into a fine emulsion having a particle size in the range of 30 to 300 nm.
9. A cosmetic composition product comprising the cosmetic composition according to any one of claims 1 to 6 and a cosmetic carrier for the cosmetic composition.
10. The cosmetic composition product of claim 9, wherein the cosmetic vehicle of the cosmetic composition comprises a facial mask, spray, wipe, lotion, cream, lotion, gel, or other cosmetic for application to the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911354018.0A CN110917105A (en) | 2019-12-25 | 2019-12-25 | Allergy-relieving cosmetic composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911354018.0A CN110917105A (en) | 2019-12-25 | 2019-12-25 | Allergy-relieving cosmetic composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110917105A true CN110917105A (en) | 2020-03-27 |
Family
ID=69860894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911354018.0A Pending CN110917105A (en) | 2019-12-25 | 2019-12-25 | Allergy-relieving cosmetic composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110917105A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476350A (en) * | 2021-07-23 | 2021-10-08 | 扬州倍加洁日化有限公司 | Wet tissue for removing milk scabs of infants and preparation method thereof |
| CN115350131A (en) * | 2022-08-01 | 2022-11-18 | 中山市天图精细化工有限公司 | Relieving and anti-inflammatory composition aerosol and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841133A1 (en) * | 2002-06-25 | 2003-12-26 | Vincience | Cosmetic or pharmaceutical composition useful for treating or preventing symptoms of skin aging and improving the appearance of the skin comprises a cork extract |
| CN1478463A (en) * | 2002-07-24 | 2004-03-03 | ������������ʽ���� | Whitening cosmetic |
| ES2541379A1 (en) * | 2014-01-17 | 2015-07-17 | Isabel FALCÓN ROSA | Acorn natural cosmetics (Machine-translation by Google Translate, not legally binding) |
| WO2017001707A1 (en) * | 2015-06-30 | 2017-01-05 | Falcón Rosa Isabel | Natural acorn cosmetic |
| CN106491481A (en) * | 2016-09-22 | 2017-03-15 | 皖南医学院 | A kind of skin whitening, moisturizing anti-aging toxin-expelling and face nourishing bath foam and preparation method thereof |
| CN108403521A (en) * | 2011-03-28 | 2018-08-17 | 玫琳凯有限公司 | Topical skin composition and application thereof |
| CN109394590A (en) * | 2018-12-29 | 2019-03-01 | 广州艾蓓生物科技有限公司 | A kind of soft foundation compositions of crease-resistant silk and preparation method thereof |
| CN109771339A (en) * | 2019-03-13 | 2019-05-21 | 中国热带农业科学院椰子研究所 | A kind of preparation method of the coconut oil nano emulsions with skin whitening, moisturizing |
-
2019
- 2019-12-25 CN CN201911354018.0A patent/CN110917105A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841133A1 (en) * | 2002-06-25 | 2003-12-26 | Vincience | Cosmetic or pharmaceutical composition useful for treating or preventing symptoms of skin aging and improving the appearance of the skin comprises a cork extract |
| CN1478463A (en) * | 2002-07-24 | 2004-03-03 | ������������ʽ���� | Whitening cosmetic |
| CN108403521A (en) * | 2011-03-28 | 2018-08-17 | 玫琳凯有限公司 | Topical skin composition and application thereof |
| ES2541379A1 (en) * | 2014-01-17 | 2015-07-17 | Isabel FALCÓN ROSA | Acorn natural cosmetics (Machine-translation by Google Translate, not legally binding) |
| WO2017001707A1 (en) * | 2015-06-30 | 2017-01-05 | Falcón Rosa Isabel | Natural acorn cosmetic |
| CN106491481A (en) * | 2016-09-22 | 2017-03-15 | 皖南医学院 | A kind of skin whitening, moisturizing anti-aging toxin-expelling and face nourishing bath foam and preparation method thereof |
| CN109394590A (en) * | 2018-12-29 | 2019-03-01 | 广州艾蓓生物科技有限公司 | A kind of soft foundation compositions of crease-resistant silk and preparation method thereof |
| CN109771339A (en) * | 2019-03-13 | 2019-05-21 | 中国热带农业科学院椰子研究所 | A kind of preparation method of the coconut oil nano emulsions with skin whitening, moisturizing |
Non-Patent Citations (4)
| Title |
|---|
| 上海新高姿化妆品有限公司: "高姿烟酰胺焕亮紧致安瓶精华液", 《国产非特殊用途化妆品备案信息服务平台（FTBA.NMPA.GOV.CN:8181/FTBAN/FW.JSP）》 * |
| 乔延江: "《中华医学百科全书•中药制剂学》", 30 April 2017, 中国协和医科大学出版社 * |
| 奥特姆伯格著，霍炜译: "《女人四十岁后如何年轻十岁》", 30 September 2009, 广东世界图书出版公司 * |
| 张媛: "《中药制剂技术》", 31 August 2012, 河南科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476350A (en) * | 2021-07-23 | 2021-10-08 | 扬州倍加洁日化有限公司 | Wet tissue for removing milk scabs of infants and preparation method thereof |
| CN113476350B (en) * | 2021-07-23 | 2024-02-09 | 扬州倍加洁日化有限公司 | Wet tissue for removing baby scab and preparation method thereof |
| CN115350131A (en) * | 2022-08-01 | 2022-11-18 | 中山市天图精细化工有限公司 | Relieving and anti-inflammatory composition aerosol and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI767351B (en) | A kind of double-dose essence and preparation method thereof | |
| KR101562560B1 (en) | Natural extract fermentation-maturity composition for preventing skin aging and improving skin wrinkle, Natural cosmetics containing that and Manufacturing method thereof | |
| CN106109284B (en) | A kind of facial mask and preparation method thereof | |
| WO2018196482A1 (en) | Skin care cosmetic composition | |
| CN105902408B (en) | Cosmetic composition containing brown alga and red algae essence | |
| CN106236687B (en) | A kind of crease-resistant face cream of chlorophyll and preparation method thereof | |
| CN112641856B (en) | Anti-aging traditional Chinese medicine composition | |
| CN110075018B (en) | Hair care composition micro-nano emulsion containing tea polyphenol and fibroin and preparation method thereof | |
| JP5117061B2 (en) | Moisturizing composition | |
| CN109330965B (en) | A cosmetic composition containing plant extract | |
| KR20210043318A (en) | Skin cream cosmetic composition containing natural extract compound | |
| CN110787088A (en) | Basic composition for lip wrinkle fading and preparation method and application thereof | |
| CN110917105A (en) | Allergy-relieving cosmetic composition and preparation method thereof | |
| CN107669617A (en) | The tender skin cosmetics of natural anti-wrinkle | |
| CN104027280A (en) | Anti-aging traditional Chinese medicine composition and application of anti-aging traditional Chinese medicine composition in cosmetics | |
| JP2001354517A (en) | Skin care preparation | |
| CN108113924A (en) | A kind of composite plant Shu Min agent and preparation method and application | |
| JP2005289999A (en) | Cosmetic composition containing extract of zizyphus jujuba and extract of juglans sinensis | |
| JP6416433B1 (en) | Topical skin preparation | |
| KR20180092599A (en) | Cosmetic composition using wild ginseng | |
| JP3934666B1 (en) | Moisturizing composition | |
| CN114344219A (en) | Aromatic plant composition for treating red swelling, itching and pain of skin and preparation method thereof | |
| DE102005033009A1 (en) | Pharmaceutical, dermatological or cosmetic preparation, useful e.g. sun protective cream and cleansing milk, comprises a part of aqueous phase or water of freshly prepared aqueous plant content | |
| KR102071600B1 (en) | Cream composition manufacturing method for preventing of sensitive-skin and skin-trouble | |
| CN110013462B (en) | Artemisia argyi paste for whitening and protecting skin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200327 |
|
| RJ01 | Rejection of invention patent application after publication |