JP5117061B2 - Moisturizing composition - Google Patents
Moisturizing composition Download PDFInfo
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- JP5117061B2 JP5117061B2 JP2007025892A JP2007025892A JP5117061B2 JP 5117061 B2 JP5117061 B2 JP 5117061B2 JP 2007025892 A JP2007025892 A JP 2007025892A JP 2007025892 A JP2007025892 A JP 2007025892A JP 5117061 B2 JP5117061 B2 JP 5117061B2
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Description
本発明は、米醗酵液と、特定の成分を組み合わせて用いることにより、皮膚の水分保持能が相乗的に向上した、保湿用組成物に関する。 The present invention relates to a moisturizing composition in which the moisture retention ability of the skin is synergistically improved by using a rice fermentation broth and a specific component in combination.
従来、薬用植物をはじめとする多種類の植物の抽出物が皮膚外用剤に用いられてきた（例えば、非特許文献１，非特許文献２等）。近年、自然志向及び動物愛護による植物志向の高まりを受けて、ますます植物や菌類抽出物に有効成分を求める傾向が高まっている。 Conventionally, extracts of many kinds of plants including medicinal plants have been used for external preparations for skin (for example, Non-Patent Document 1, Non-Patent Document 2, etc.). In recent years, with the increase in plant orientation due to nature and animal welfare, there is an increasing tendency to seek active ingredients in plant and fungal extracts.
しかし植物や菌類の抽出物は、それぞれが多様な作用を有するものの、総じてその作用はさほど強くないことが多く、皮膚外用剤において、期待する作用効果の生じる量の植物や菌類抽出物を含有させると、好ましくない着色，着臭が見られたり、製剤安定性の低下が見られたりすることがあった。複数の植物や菌類抽出物を併用して作用効果の増強を図る試みもなされてはいるが、皮膚の生理機能には種々の因子が複雑に関与するため、皮膚の状態を十分に向上させることは困難である。 However, although plant and fungal extracts each have a variety of actions, the action is generally not so strong, and the external preparation for skin contains an amount of plant or fungal extract that produces the expected action and effect. In some cases, unfavorable coloring and odor were observed, and the stability of the preparation was decreased. Although attempts have been made to enhance the action and effect by using multiple plant and fungal extracts in combination, various factors are involved in the physiological functions of the skin, so the skin condition must be sufficiently improved. It is difficult.
一方、米醗酵液は従来より、美容や健康に良いと云われている。特に最近では米発酵エキスはアトピー性皮膚炎に効果があることが大学病院や国立小児病院等の研究で明らかになっている。このような米発酵エキスの特性を利用して最近入浴剤および化粧品への利用が検討されている（特許文献１）。 On the other hand, rice fermentation liquor is conventionally said to be good for beauty and health. In recent years, researches by university hospitals and national pediatric hospitals have revealed that rice fermentation extract is effective for atopic dermatitis. Utilization of such a fermented rice extract for bathing agents and cosmetics has recently been studied (Patent Document 1).
しかしながら、米醗酵液は入浴剤や化粧品に使用した場合、肌の保温効果は認められるが、保湿効果の点で十分と言えなかった。そのため米醗酵液単独で充分な保湿効果を発揮する量を配合すると、経時で含有成分であるアミノ酸類が析出したり、着色が認められるという問題点があった。 However, when the rice fermentation liquor is used for bathing agents and cosmetics, the heat-retaining effect of the skin is recognized, but it cannot be said that the moisturizing effect is sufficient. For this reason, when an amount capable of exhibiting a sufficient moisturizing effect with the rice fermentation liquor alone is blended, there is a problem in that amino acids as the components are precipitated over time or coloring is observed.
そこで本発明においては、米醗酵液の有する保湿効果を相乗的に向上させた保湿用組成物を得ることを目的とした。 Therefore, an object of the present invention is to obtain a moisturizing composition that synergistically improves the moisturizing effect of the rice fermentation broth.
上記目的を達成するために、本発明は、米醗酵液とともに、ゲットウ、コウスイハッカ、カロット、フキタンポポ、ビロードアオイ、タチジャコウソウ、ハマメリス、パセリ、シラカンバ、ブナ、イチョウ、ゲンノショウコ、ユキノシタ、セイヨウニワトコ、ヒカゲノカズラ、オウカホウシュン、カシア、ナツメ、シャクヤク、ブクリョウタケ、ノイバラ、チョウジ、ムクロジ、キハダ、コガネバナ、クララ、オドリコソウ、スギゴケ、ナツノハナワラビ、アカキナノキ、α−Ｄ−グルコピラノシルグリセロールから選択される１種又は２種以上の成分を併用してなる保湿用組成物を提供する。 In order to achieve the above-mentioned object, the present invention, together with rice fermentation liquor, ghetto, kousei mint, carrot, dandelion, velvet mallow, velvet mushroom, holly squirrel, parsley, birch, beech, ginkgo, genus shoko, yukinoshita, elderberry, lizard 1 selected from the group consisting of, Okahoushun, Cassia, Jujube, Peonies, Bukkyoutake, Nobara, Clove, Mukuroji, Yellowfin, Scarlet moth, Clara, Olysam, Sugigo, Natsunohanabi, Akinaki, α-D-glucopyranosylglycerol A moisturizing composition comprising a seed or two or more components in combination is provided.
かかる保湿用組成物によれば、米醗酵液とともに、ゲットウ、コウスイハッカ、カロット、フキタンポポ、ビロードアオイ、タチジャコウソウ、ハマメリス、パセリ、シラカンバ、ブナ、イチョウ、ゲンノショウコ、ユキノシタ、セイヨウニワトコ、ヒカゲノカズラ、オウカホウシュン、カシア、ナツメ、シャクヤク、ブクリョウタケ、ノイバラ、チョウジ、ムクロジ、キハダ、コガネバナ、クララ、オドリコソウ、スギゴケ、ナツノハナワラビ、アカキナキ、α−Ｄ−グルコピラノシルグリセロールから選択される１種又は２種以上の成分を用いることにより、皮膚の水分保持能を飛躍的に高めることができる。その結果、本発明の保湿用組成物によれば、少量の保湿用組成物を用いることで、優れた保湿効果を得ることができる。 According to such a moisturizing composition, together with the rice fermentation broth, ghetto, kousei mint, carrot, dandelion, velvet aoi, prickly moth, hamamelis, parsley, birch, beech, ginkgo, genus shoko, yukinoshita, elderberry, lizard hawk 1 or 2 selected from Shun, Cassia, Jujube, Peonies, Bamboo Bamboo, Neubara, Clove, Mukuroji, Yellowfin, Scarlet, Clara, Odorikosou, Sugigo, Natsunohanabi, Akakinaki, α-D-glucopyranosylglycerol By using more than one kind of component, the moisture retention ability of the skin can be dramatically increased. As a result, according to the moisturizing composition of the present invention, an excellent moisturizing effect can be obtained by using a small amount of the moisturizing composition.
本発明の保湿用組成物は、米醗酵液とともに、ゲットウ、コウスイハッカ、カロット、フキタンポポ、ビロードアオイ、タチジャコウソウ、ハマメリス、パセリ、シラカンバ、ブナ、イチョウ、ゲンノショウコ、ユキノシタ、セイヨウニワトコ、ヒカゲノカズラ、オウカホウシュン、カシア、ナツメ、シャクヤク、ブクリョウタケ、ノイバラ、チョウジ、ムクロジ、キハダ、コガネバナ、クララ、オドリコソウ、スギゴケ、ナツノハナワラビ、アカキナノキ、α−Ｄ−グルコピラノシルグリセロールから選択される１種又は２種以上の成分を用いることにより、水分保持能が相乗的に向上し、優れた保湿効果を発揮するものである。 The moisturizing composition of the present invention includes rice fermented liquor, ghetto, kousei mint, carrot, dandelion, velvet aoi, papaver, hammamels, parsley, birch, beech, ginkgo, genus shoko, yukinoshita, elderberry, lizard hawk One or two selected from Shun, Cassia, Jujube, Peonies, Bukkyoutake, Neubara, Clove, Mukuroji, Yellowfin, Scarlet, Clara, Olysam, Sugioke, Natsunohanababi, Akinaki, α-D-glucopyranosylglycerol By using more than one component, the water retention ability is synergistically improved and exhibits an excellent moisturizing effect.
以下、本発明をその好適な実施形態に即して詳細に説明する。 Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof.
本発明の保湿用組成物は、米醗酵液とともに、ゲットウ、コウスイハッカ、カロット、フキタンポポ、ビロードアオイ、タチジャコウソウ、ハマメリス、パセリ、シラカンバ、ブナ、イチョウ、ゲンノショウコ、ユキノシタ、セイヨウニワトコ、ヒカゲノカズラ、オウカホウシュン、カシア、ナツメ、シャクヤク、ブクリョウタケ、ノイバラ、チョウジ、ムクロジ、キハダ、コガネバナ、クララ、オドリコソウ、スギゴケ、ナツノハナワラビ、アカキナノキ、α−Ｄ−グルコピラノシルグリセロールから選択される１種又は２種以上の成分を用いることを特徴とするものである。以下、本発明の保湿用組成物を構成する各成分について説明する。 The moisturizing composition of the present invention includes rice fermented liquor, ghetto, kousei mint, carrot, dandelion, velvet aoi, papaver, hammamels, parsley, birch, beech, ginkgo, genus shoko, yukinoshita, elderberry, lizard hawk One or two selected from Shun, Cassia, Jujube, Peonies, Bukkyoutake, Neubara, Clove, Mukuroji, Yellowfin, Scarlet, Clara, Olysam, Sugioke, Natsunohanababi, Akinaki, α-D-glucopyranosylglycerol It is characterized by using more than seed components. Hereinafter, each component constituting the moisturizing composition of the present invention will be described.
本発明の成分（Ａ）である米醗酵液は、米もしくは米ぬかを、酵素分解または麹による糖化、酒母或いは酵母による醗酵を行うことにより得られるものを用いる。 The rice fermentation liquid which is the component (A) of the present invention uses a rice or rice bran obtained by enzymatic decomposition or saccharification with koji, or fermentation with a liquor or yeast.
本発明において用いるゲットウ（Alpinia speciosa (Wendl.) K. Schuｍ.）は、ショウガ科（Zingiberaceae）に属する多年草で、葉，茎，花，根等の各部位を用いることができるが、葉若しくは花を用いることが好ましい。 Ghetto ( Alpinia speciosa (Wendl.) K. Schum.) Used in the present invention is a perennial plant belonging to the family Gingidae ( Zingiberaceae ), and each part such as leaf, stem, flower, root, etc. can be used. Is preferably used.
本発明において用いるコウスイハッカ（メリッサ）（Melissa officinalis L.）はシソ科（Labiatae）に属する多年草で、葉，茎，根，花等の各部位及び全草を用いることができるが、葉を用いることが好ましい。 Precipitation peppermint used in the present invention (Melissa) (Melissa officinalis L.) is a perennial plant belonging to the Labiatae (Labiatae), leaves, stems, roots, it is possible to use the site and whole plant flowers like, using a foliar It is preferable.
本発明において用いるカロット（Daucus carota L.）はセリ科（Umbelliferae）に属する多年草で、葉，茎，根等の各部位及び全草を用いることができるが、根部を用いることが好ましい。 The carrot ( Daucus carota L.) used in the present invention is a perennial plant belonging to the family Umbelliferae , and each part such as leaves, stems and roots and whole grass can be used, but the root is preferably used.
本発明において用いるフキタンポポ（Tussilago farfara L.）はキク科（Compositae）に属する多年草で、葉，茎，花，根等の各部位及び全草を用いることができるが、葉又は花を用いることが好ましい。 The dandelion ( Tussilago farfara L.) used in the present invention is a perennial plant belonging to the Compositae family, and each part such as leaves, stems, flowers, roots and whole plants can be used, but leaves or flowers can be used. preferable.
本発明において用いるビロードアオイ（アルテア）（Althaea officinalis L.）はアオイ科（Malvaceae）に属する多年草で、葉，茎，花，根等の各部位及び全草を用いることができるが、葉又は根を用いることが好ましい。 Marshmallow used in the present invention (Altea) (Althaea officinalis L.) is a perennial plant belonging to the Malvaceae (Malvaceae), leaves, stems, flowers, it is possible to use the site and whole plant roots and the like, leaves or roots Is preferably used.
本発明において用いるタチジャコウソウ（Thymus vulgaris L.）は、シソ科（Labiatae）に属する常緑の小低木で、花，葉，枝等各部位を用いることができるが、本発明の目的には帯花期の全草を用いることが好ましい。 Thymus vulgaris used in the present invention (Thymus vulgaris L.) is a small shrub evergreen belonging to Labiatae (Labiatae), flowers, leaves, can be used branches like each part, the band for the purposes of the present invention flowering season It is preferable to use the whole plant.
本発明において用いるハマメリス（Hamamelis virginiana L.）は、マンサク科（Hamamelidaceae）に属する１年草で、葉，茎，花，果実，根等の各部位及び全草を用いることができるが、葉を用いることが好ましい。 The Hamamelis virginiana L. used in the present invention is an annual plant belonging to the family Hamamelidaceae and can use all parts of leaves, stems, flowers, fruits, roots, etc. and whole plants. It is preferable to use it.
本発明において用いるパセリ（Petroselinum crispum (Mill.) Nym. Ex A.W.Hill.）はセリ科（Umbelliferae）に属する２年草又は多年草で、葉，茎，花，果実等の各部位及び全草を用いることができるが、葉及び茎を用いることが好ましい。 The parsley ( Petroselinum crispum (Mill.) Nym. Ex AWHill.) Used in the present invention is a biennial or perennial plant belonging to the family Umbelliferae and uses all parts such as leaves, stems, flowers, fruits and whole plants. However, it is preferable to use leaves and stems.
本発明において用いるシラカンバ（Betula platyphylla Sukatchev var.japonica Hara）は、カバノキ科（Betulaceae）に属する落葉高木で、根、根茎、心材、樹皮、葉，枝，花等の各部位及び全木を用いることができるが、根、根茎、心材、樹皮、葉等が好ましく、この中でも特に樹皮からの抽出物が保湿効果の点から好ましい。 The birch ( Betula platyphylla Sukatchev var. Japonica Hara) used in the present invention is a deciduous tree belonging to the birch family ( Betulaceae ), and uses all parts such as roots, rhizomes, heartwood, bark, leaves, branches, flowers, and whole trees. However, roots, rhizomes, heartwood, bark, leaves and the like are preferable, and among these, extracts from bark are particularly preferable from the viewpoint of moisturizing effect.
本発明において用いるブナは、イヌブナ（Fagus japonica Maxim.）及び／又はブナ（Fagus crenata Blume）を用いることができる。これらは、ブナ科（Fagaceae）に属する落葉高木で、葉，枝，樹皮，花，果実等の各部位及び全木を用いることができるが、葉又は樹皮或いは幼芽を用いることが好ましい。 As the beech used in the present invention, dog beech ( Fagus japonica Maxim.) And / or beech ( Fagus crenata Blume) can be used. These are deciduous trees belonging to the family Beechaceae ( Fagaceae ), and each part of the leaves, branches, bark, flowers, fruits, etc. and the whole tree can be used, but it is preferable to use leaves, bark or shoots.
本発明において用いるイチョウ（Ginkgo biloba L.）は、イチョウ科（Ginkgoaceae）に属する雌雄異株の落葉高木で、葉，枝，樹皮，花，種子等の各部位及び全木を用いることができるが、葉又は種子を用いることが好ましい。 The ginkgo ( Ginkgo biloba L.) used in the present invention is a hermaphroditic deciduous tree belonging to the family Ginkgoaceae ( Ginkgoaceae ), and each part of the leaves, branches, bark, flowers, seeds and the whole tree can be used. Preferably, leaves or seeds are used.
本発明において用いるゲンノショウコ（Geranium nepalense Sweet. var. thunbergii (Sieb. et Zucc.) Kudo）は、フウロソウ科（Geraniaceae）に属する多年草で、葉，茎，花，果実等の各部位及び全草を用いることができるが、全草を用いることが好ましい。 Geranium nepalense Sweet. Var. Thunbergii (Sieb. Et Zucc.) Kudo used in the present invention is a perennial plant belonging to the family Geraniaceae , and uses parts such as leaves, stems, flowers, fruits and whole plants. However, it is preferable to use whole grass.
本発明において用いるユキノシタ（Saxifraga stolonifera Meerb.）は、ユキノシタ科（Saxifragaceae）に属する多年草で、葉，茎，花，果実等の各部位及び全草を用いることができるが、葉，茎などの地上部位を用いることが好ましい。 Saxifraga stolonifera Meerb. Used in the present invention is a perennial plant belonging to the family Saxifragaceae ( Saxifragaceae ), and each part of leaves, stems, flowers, fruits and the like and whole grasses can be used. It is preferable to use a site.
本発明において用いるセイヨウニワトコ（Sambucus nigra L.）は、スイカズラ科（Caprifoliaceae）に属する多年草で、葉，茎，花，根，果実，漿果等の各部位及び全草を用いることができるが、花又は漿果を用いることが好ましい。 Sambucus nigra L. used in the present invention is a perennial plant belonging to the family Caprifoliaceae , and each part of leaves, stems, flowers, roots, fruits, berries, etc. and whole grasses can be used. Or it is preferable to use berries.
本発明において用いるヒカゲノカズラ（Lycopodium clavatum L.またはLycopodium clavayum L. var. nipponicum Nakai）は、ヒカゲノカズラ科（Lycopodiaceae）に属する常緑性の多年草で、根、茎、葉、胞子嚢、胞子等の各部位および全草を用いることができるが、全草を用いることが好ましい。また、その全草を乾燥させたものは、「シンキンソウ」と呼ばれる生薬であり、かかる生薬を用いることもできる。 Lycopodium used in the present invention (Lycopodium clavatum L. or Lycopodium clavayum L. var. Nipponicum Nakai) is a evergreen perennial belonging to lycopodiaceae (Lycopodiaceae), roots, the stem, leaves, sporangia, spores etc. and Although whole grass can be used, it is preferable to use whole grass. Moreover, what dried the whole plant is a crude drug called "Shinkinsou", and such a crude drug can also be used.
本発明において用いるオウカホウシュン（Primula sikkimensis Hook.）は、サクラソウ科（Primulaceae）に属する多年草で、葉、茎、花、種子、根等の各部位及び全草を用いることができるが、花を用いることが好ましい。また、その近縁としてジョウモンホウシュン（Primula vittata Bur. et Franch.）も同様に用いることができる。また、オウカホウシュンおよびジョウモンホウシュンの花を乾燥させたものは、「ホウシュンカ」と呼ばれる生薬であり、かかる生薬を用いることもできる。 The primula sikkimensis Hook. Used in the present invention is a perennial plant belonging to the family Primulaceae ( Primulaceae ), and each part of the leaves, stems, flowers, seeds, roots and the like and whole plants can be used. It is preferable to use it. In addition, as a close relationship, Primula vittata Bur. Et Franch. Can be used as well. Moreover, what dried the flower of Okahou shun and Jomon houshun is a crude drug called "Houshunka", and such a crude drug can also be used.
本発明において用いるカシア（Cinnamomum cassia Presl.）は、クスノキ科（Lauraceae）に属する小高木で、葉、枝、幹、樹皮、根、花、果実等の各部位を用いることができるが、樹皮を用いることが好ましい。また、カシアの樹皮やその同属植物の樹皮を乾燥させたものは、「ケイヒ」と呼ばれる生薬であり、かかる生薬を用いることもできる。 Cassia ( Cinnamomum cassia Presl.) Used in the present invention is a small tree belonging to the family Lauraceae , and can use various parts such as leaves, branches, trunks, bark, roots, flowers, fruits, etc. It is preferable to use it. Moreover, what dried the bark of the cassia bark and the bark of its genus plant is a crude drug called "Keihi", and such a crude drug can also be used.
本発明において用いるナツメ（Ziziphus jujuba Mill.）は、クロウメモドキ科（Rhamnaceae）に属する高木で、葉，枝，幹，樹皮，根，花，果実等の各部位を用いることができるが、果実を用いることが好ましい。また、ナツメの果実を乾燥させたものは、「タイソウ」と呼ばれる生薬であり、かかる生薬を用いることもできる。 The jujuba mill ( Ziziphus jujuba Mill.) Used in the present invention is a high tree belonging to the family Rhamnaceae ( Rhamnaceae ), and each part such as a leaf, a branch, a trunk, a bark, a root, a flower, and a fruit can be used, but a fruit is used. It is preferable. Moreover, what dried the fruit of a jujube is a crude drug called "Taisou", and such a crude drug can also be used.
本発明において用いるシャクヤク（Paeonia lactiflora Pall.）は、ボタン科（Paeoniaceae）に属する多年草で、葉，茎，花，果実，根等の各部位及び全草を用いることができるが、根を用いることが好ましい。 The peony ( Paeonia lactiflora Pall.) Used in the present invention is a perennial plant belonging to the department of the button family ( Paeoniaceae ), and each part of the leaves, stems, flowers, fruits, roots, etc. and whole plants can be used, but the roots should be used. Is preferred.
本発明において用いるブクリョウタケ（Poria cocos (Fr.) Wolf）は、サルノコシカケ科（Polyporaceae）に属する担子菌類である。また、ブクリョウタケの菌核を乾燥させたものは、「ブクリョウ」と呼ばれる生薬であり、かかる生薬を用いることもできる。 Bokuryotake ( Poria cocos (Fr.) Wolf) used in the present invention is a basidiomycete belonging to the family Polyporaceae . Moreover, what dried the mycorrhizal sclerotium is a crude drug called "Bukuryo", and such a crude drug can also be used.
本発明において用いるノイバラ（Rosa multiflora Thunb.、Rosa polvantha Sieb. Et Zucc. var. genuina Nakai）は、バラ科（Rosaceae）に属する植物で、葉，枝，幹，樹皮，根，花，果実等の各部位を用いることができるが、果実を用いることが好ましい。また、ノイバラ（Rosa multiflora Thunb.、Rosa polvantha Sieb. Et Zucc. var. genuina Nakai）又はその近縁植物の偽果又は果実は、「エイジツ」と呼ばれる生薬であり、かかる生薬を用いることもできる。近縁植物としては、テリハノイバラ（Rosa wichuraiana Creign var.anpullicarpa Honda）、フジイバラ（Rosa fujisanensis Makino）、ヤマハマナス（Rosa davurica Pallas、Rosa willdenowii Sprengel）等が挙げられる。 Neu rose ( Rosa multiflora Thunb., Rosa polvantha Sieb. Et Zucc. Var. Genuina Nakai) used in the present invention is a plant belonging to the family Rosaceae , such as leaves, branches, stems, bark, roots, flowers, fruits, etc. Although each part can be used, it is preferable to use a fruit. Moreover, the false fruit or fruit of a rose ( Rosa multiflora Thunb., Rosa polvantha Sieb. Et Zucc. Var. Genuina Nakai) or its related plant is a crude drug called “agetsu”, and such a crude drug can also be used. The closely related plants, Rosa Wichuraiana (Rosa wichuraiana Creign var. Anpullicarpa Honda ), Fujiibara (Rosa fujisanensis Makino), Yamahamanasu (Rosa davurica Pallas, Rosa willdenowii Sprengel ) , and the like.
本発明において用いるチョウジ（Syzygium aromaticum (L.) Merril et Perry）は、フトモモ科（Myrtaceae）に属する高木で、葉，枝，幹，樹皮，根，花，果実等の各部位を用いることができるが、蕾若しくは葉を用いることが好ましい。また、チョウジの蕾を乾燥させたものは、「チョウジ」とよばれる生薬であり、かかる生薬を用いることもできる。 The clove used in the present invention ( Syzygium aromaticum (L.) Merril et Perry) is a high tree belonging to the Myrtaceae family and can use various parts such as leaves, branches, trunks, bark, roots, flowers, and fruits. However, it is preferable to use cocoons or leaves. Moreover, what dried the clove of a clove is a crude drug called "clove", and such a crude drug can also be used.
本発明において用いるムクロジ（Sapindus mukurossi Gaertn.）は、ムクロジ科（Sapindaceae）に属する落葉高木で、花，葉，枝幹，樹皮，果実等各部位を用いることができるが、果皮又は樹皮を用いることが好ましい。 The mugwort ( Sapindus mukurossi Gaertn.) Used in the present invention is a deciduous tree belonging to the family Sapindaceae , and can use each part such as a flower, a leaf, a branch trunk , a bark, a fruit, but a pericarp or bark is used. Is preferred.
本発明において用いるキハダ（Phellodendron amurense Pupr.）はミカン科（Rutaceae）に属する高木で、葉，枝，幹，樹皮，根，花，果実等の各部位を用いることができるが、樹皮を用いることが好ましい。また、キハダの樹皮を乾燥させたものは、「オウバク」とよばれる生薬であり、かかる生薬を用いることもできる。 Yellowfin employed in the present invention (Phellodendron amurense Pupr.) In Takagi that belong to Rutaceae (Rutaceae), leaves, branches, stem, bark, roots, flowers, it is possible to use the site such as fruits, the use of bark Is preferred. Further, dried dried bark bark is a herbal medicine called “Owaku”, and such herbal medicine can also be used.
本発明において用いるコガネバナ（Scutellaria baicalensis Georg.）は、シソ科（Labiatae）タツナミソウ属（Scutellaria L.）に属する多年草で、葉，茎，花，果実，根等の各部位及び全草を用いることができるが、根を用いることが好ましい。また、コガネバナ及びその同属植物の根を乾燥させたものは、「オウゴン」と呼ばれる生薬であり、かかる生薬を用いることもできる。 The Scutellaria baicalensis Georg. Used in the present invention is a perennial plant belonging to the genus Labiatae ( Scutellaria L.), and each part of leaves, stems, flowers, fruits, roots, etc. and whole plants are used. Although it is possible, it is preferable to use roots. Moreover, what dried the roots of Scutellaria and its genus plant is a crude drug called "Ogon", and such a crude drug can also be used.
本発明において用いるクララ（Sophora flavescens Ait.）は、マメ科エンジュ属に属する多年草で、葉，茎，花，果実，根等の各部位及び全草を用いることができるが、根を用いることが好ましい。また、クララの根を乾燥させたものは、「苦参」と呼ばれる生薬であり、かかる生薬を用いることもできる。 Clara ( Sophora flavescens Ait.) Used in the present invention is a perennial plant belonging to the genus Legumeaceae, and each part such as leaves, stems, flowers, fruits, roots, and whole plants can be used. preferable. Moreover, what dried the roots of Clara is a crude drug called "bitter", and such a crude drug can also be used.
本発明において用いるオドリコソウは、シソ科（Labiatae）オドリコソウ属（Lamium L.）に属する草本植物で、オドリコソウ（Lamium album ;Lamium barbatum）及びその変種、ヒメオドリコソウ（Lamium purpureum L.）の葉，茎，花，果実，根等の各部位及び全草を用いることができるが、花、茎、葉を用いることが好ましい。 The nettle used in the present invention is a herbaceous plant belonging to the genus Labiatae ( Lamium L.), and the leaves, stems, and flowers of Laminum album ( Lamium barbatum) and its varieties, Lamium purpureum L. , Fruits, roots, etc. and whole plants can be used, but flowers, stems and leaves are preferably used.
本発明において用いるスギゴケ（Polytrichum juniperinum Wild. ex Hedw.）は、スギゴケ科（Polytrichaceae）に属する雌雄異株のコケ植物で、葉、茎、さく、胞子等の各部位及び全草を用いることができるが、全草を用いることが望ましい。また、近縁のウマスギゴケ（Polytrichum commune Hedw.）、オオスギゴケ（Polytrichum formosum Hedw.）等も同様に用いることもできる。 The cedar moss ( Polytrichum juniperinum Wild. Ex Hedw.) Used in the present invention is a male and female moss plant belonging to the family Polytrichaceae ( Polytrichum juniperinum Wild. Ex Hedw.). However, it is desirable to use whole grass. In addition, close relatives such as Polytrichum commune Hedw., Polytrichum formosum Hedw. And the like can also be used.
本発明において用いるナツノハナワラビは、ハナヤスリ科（Ophioglossaceae）ナツノハナワラビ属（Botrypus）に属する真嚢シダ類で、胞子、胞子嚢穂、葉、茎、根等の何れの部分を用いても良く、さらにはその全草を用いることもできる。特にナツノハナワラビの根つきの全草は、「シュンフケン（春不見）」と呼ばれる生薬であり、かかる生薬を用いることもできる。 Natsunohanaburabi used in the present invention is a true vesicle fern belonging to the genus Botrypus ( Ophioglossaceae ), and any part of spores, spores, leaves, stems, roots, etc. may be used. In addition, the whole plant can be used. In particular, the whole plant with roots of Natsunohanawarabi is a herbal medicine called “Shunfuken”, and such herbal medicine can also be used.
本発明において用いるアカキナノキ（Cinchona succirubra Pavon et Klotzsch）は、アカネ科（Rubiaceae）キナ属（Cinchona L.）に属する高木で、葉，枝，幹，樹皮，根，根の樹皮，花，果実等の各部位を用いることができるが、根の樹皮を用いることが好ましい。また、アカキナノキ（Cinchona succirubra Pavon et Klotzsch）及びその同属植物の枝，幹，根の樹皮を乾燥させたものは、「キナ」と呼ばれる生薬であり、かかる生薬を用いることもできる。アカキナノキの同属植物としては、ボリビアキナノキ（Cinchona ledgeriana Moens et Klotzsch），シンコナ・オフィシナリス（Cinchona officinalis L.），シンコナ・カリサヤ（Cinchona calisaya Weddell.），シンコナ・ピタエンシス（Cinchona pitayensis Wedd.）等が挙げられる。 The red cypress ( Cinchona succirubra Pavon et Klotzsch) used in the present invention is a tree belonging to the genus Rubiaceae (Cinchona L.), and includes leaves, branches, trunks, bark, roots, root bark, flowers, fruits, etc. Although each part can be used, it is preferable to use a root bark. Moreover, what dried the bark of the branch, the trunk, and the root of a red linden tree ( Cinchona succirubra Pavon et Klotzsch) and its genus plant is a crude drug called "kina", and such a crude drug can also be used. Examples of plants belonging to the red linden tree include Cinchona ledgeriana Moens et Klotzsch, Cinchona officinalis L., Cinchona calisaya Weddell., Cinchona pitayensis Wedd. Can be mentioned.
本発明の保湿用組成物においては、これらの植物及び菌類をそのまま用いることもできるが、製剤化の容易さの点から、抽出物を用いることが好ましい。つづいて、本発明において用いる植物及び菌類抽出物の抽出方法について述べる。 In the moisturizing composition of the present invention, these plants and fungi can be used as they are, but it is preferable to use an extract from the viewpoint of ease of formulation. Next, a method for extracting plant and fungal extracts used in the present invention will be described.
本発明において、上記各植物及び菌類は生のまま抽出操作に供しても良いが、抽出効率を考えると細切，乾燥，粉砕等の処理を行った後抽出を行うことが好ましい。抽出は、抽出溶媒に浸漬して行う。抽出効率を上げるため撹拌を行ったり、抽出溶媒中でホモジナイズしても良い。抽出温度としては、５℃程度から抽出溶媒の沸点以下の温度とするのが適切である。抽出時間は抽出溶媒の種類，抽出温度によっても異なるが、４時間〜１４日間程度とするのが適切である。また、超臨界流体，亜臨界流体を用いた抽出方法をとることもできる。 In the present invention, the above plants and fungi may be subjected to an extraction operation as they are, but in consideration of extraction efficiency, it is preferable to perform extraction after processing such as shredding, drying, and pulverization. Extraction is performed by immersing in an extraction solvent. In order to increase extraction efficiency, stirring may be performed or homogenization may be performed in an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 4 hours to 14 days. Moreover, the extraction method using a supercritical fluid and a subcritical fluid can also be taken.
抽出溶媒としては、水を用いることが最も好ましいが、そのほか、メタノール，エタノール，プロパノール，イソプロパノール等の低級アルコール、１，３−ブチレングリコール，プロピレングリコール，ジプロピレングリコール，グリセリン等の多価アルコール、ジエチルエーテル，ジプロピルエーテル等のエーテル類、酢酸エチル，酢酸ブチル等のエステル類、アセトン，エチルメチルケトン等のケトン類等の極性有機溶媒、また、生理食塩水，リン酸緩衝液，リン酸緩衝生理食塩水等、あるいは石油エーテル，ｎ−ヘキサン，ｎ−ペンタン，ｎ−ブタン，ｎ−オクタン，シクロヘキサン等の炭化水素類、四塩化炭素，クロロホルム，ジクロロメタン，トリクロロエチレン，ベンゼン，トルエンなどの無極性若しくは低極性溶媒から選択される１種又は２種以上の溶媒を好適に使用することができる。また、抽出に水，二酸化炭素，エチレン，プロピレン，エタノール，メタノール，アンモニア等の超臨界流体，亜臨界流体を用いても良く、この際エントレーナーとして上記の溶媒を用いることもできる。 As the extraction solvent, water is most preferably used. In addition, lower alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, diethyl Ethers such as ether and dipropyl ether, esters such as ethyl acetate and butyl acetate, polar organic solvents such as ketones such as acetone and ethyl methyl ketone, and physiological saline, phosphate buffer, phosphate buffered physiology Non-polar or low such as saline, hydrocarbons such as petroleum ether, n-hexane, n-pentane, n-butane, n-octane, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, toluene Select from polar solvents One or more solvents can be suitably used. In addition, a supercritical fluid such as water, carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia, or a subcritical fluid may be used for extraction. In this case, the above-mentioned solvent may be used as an entrainer.
また、抽出物はそのままでも保湿用組成物に添加できるが、濃縮，乾固したものを水，極性溶媒に再度溶解したり、あるいは脱色，脱臭，脱塩等の精製処理，分画処理を行った後に用いても良い。また保存のためには、精製処理の後凍結乾燥し、用時に溶媒に溶解して用いることが好ましい。あるいは、リポソーム等のベシクル，マイクロカプセル等に内包させることもできる。 In addition, the extract can be added to the moisturizing composition as it is, but the concentrated and dried solid can be dissolved again in water or a polar solvent, or purified or fractionated by decolorization, deodorization, desalting, etc. You may use it after. For storage, it is preferable to freeze-dry after the purification treatment and dissolve in a solvent before use. Alternatively, they can be encapsulated in vesicles such as liposomes, microcapsules and the like.
本発明においては、成分（Ｂ）としてα−Ｄ−グルコピラノシルグリセロールを用いることができる。α−Ｄ−グルコピラノシルグリセロールには、（２Ｒ）−１−Ｏ−α−Ｄ−グルコピラノシルグリセロール（化１），（２Ｓ）−１−Ｏ−α−Ｄ−グルコピラノシルグリセロール（化２），２−Ｏ−α−Ｄ−グルコピラノシルグリセロール（化３）の３成分が知られており、これらより１種を単独で、若しくは２種以上の混合物を用いることができる。 In the present invention, α-D-glucopyranosylglycerol can be used as component (B). α-D-glucopyranosylglycerol includes (2R) -1-O-α-D-glucopyranosylglycerol (Chemical Formula 1), (2S) -1-O-α-D-glucopyranosyl Three components of glycerol (Chemical Formula 2) and 2-O-α-D-glucopyranosylglycerol (Chemical Formula 3) are known, and one of them can be used alone or a mixture of two or more types can be used. it can.
α−Ｄ−グルコピラノシルグリセロールを得る方法としては、カビ類のα−グルコシダーゼをグリセロール溶液中で糖類の基質に作用させる方法、清酒，味噌，みりん等の醸造物から抽出，精製する方法、イソマルトース，マルチトールなどを四酢酸鉛や過ヨウ素酸塩でグリコール開裂したものを還元する方法、あるいはＫｏｅｎｉｇｓ−Ｋｎｏｒｒ反応により合成したβ−グルコシドをアノメリゼーションした後、β−グルコシダーゼでβ−グルコシドを加水分解する方法などが挙げられるが、カビ類のα−グルコシダーゼをグリセロール溶液中で糖類の基質に作用させる方法が最も効率が良く特に好ましい。 As a method for obtaining α-D-glucopyranosylglycerol, a method in which a mold α-glucosidase is allowed to act on a saccharide substrate in a glycerol solution, a method for extraction and purification from brewed products such as sake, miso, mirin, etc. A method of reducing glycol cleavage of isomaltose, maltitol, etc. with lead tetraacetate or periodate, or β-glucoside synthesized by Koenigs-Knorr reaction and then β-glucoside with β-glucosidase The method of allowing fungal α-glucosidase to act on a saccharide substrate in a glycerol solution is the most efficient and particularly preferred.
本発明においては、米醗酵液（成分Ａ）と、ゲットウ、コウスイハッカ、カロット、フキタンポポ、ビロードアオイ、タチジャコウソウ、ハマメリス、パセリ、シラカンバ、ブナ、イチョウ、ゲンノショウコ、ユキノシタ、セイヨウニワトコ、ヒカゲノカズラ、オウカホウシュン、カシア、ナツメ、シャクヤク、ブクリョウタケ、ノイバラ、チョウジ、ムクロジ、キハダ、コガネバナ、クララ、オドリコソウ、スギゴケ、ナツノハナワラビ、アカキナノキ、α−Ｄ−グルコピラノシルグリセロールから選択される１種又は２種以上の成分（成分Ｂ）を併用して、保湿用組成物とする。成分（Ａ）と成分（Ｂ）の混合比率は限定されないが、例えば成分（Ａ）１質量部に対し成分（Ｂ）を０．０１〜１００質量部混合することができる。 In the present invention, rice fermentation liquor (component A), ghetto, kouseihakka, carrot, dandelion, velvet aoi, papaver, hammamels, parsley, white birch, beech, ginkgo, genus shoko, yukinoshita, elderberry, lizard hawk One or two selected from Shun, Cassia, Jujube, Peonies, Bukkyoutake, Neubara, Clove, Mukuroji, Yellowfin, Scarlet, Clara, Olysam, Sugioke, Natsunohanababi, Akinaki, α-D-glucopyranosylglycerol A moisturizing composition is prepared by using at least two kinds of components (component B). Although the mixing ratio of a component (A) and a component (B) is not limited, For example, 0.01-100 mass parts of components (B) can be mixed with respect to 1 mass part of components (A).
本願発明の保湿用組成物は、皮膚や毛髪に対して優れた保湿作用を発揮し、特に皮膚に対する保湿効果が高い。 The moisturizing composition of the present invention exhibits an excellent moisturizing effect on the skin and hair, and particularly has a high moisturizing effect on the skin.
本発明に係る保湿用組成物は、ローション剤，乳剤，ゲル剤，クリーム剤，軟膏剤，粉末剤，顆粒剤等、種々の剤型で提供することができる。また、化粧水，乳液，クリーム，美容液，パック等の皮膚化粧料、メイクアップベースローション，メイクアップベースクリーム等の下地化粧料、乳液状，油性，固形状等の各剤型のファンデーション，アイカラー，チークカラー等のメイクアップ化粧料、クレンジングクリーム，クレンジングローション，クレンジングフォーム，洗顔石鹸，ボディシャンプー等の皮膚洗浄料、ヘアーシャンプー，ヘアーリンス，ヘアートリートメント等の毛髪用化粧料等としても提供することができる。 The moisturizing composition according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders, granules and the like. In addition, skin cosmetics such as lotion, milky lotion, cream, beauty essence, packs, foundation cosmetics such as makeup base lotion and makeup base cream, foundations for each dosage form such as emulsion, oily, solid, etc. Also provided as makeup cosmetics such as color and cheek color, cleansing cream, cleansing lotion, cleansing foam, skin cleanser such as facial soap, body shampoo, hair cosmetic such as hair shampoo, hair rinse, hair treatment etc. be able to.
なお本発明に係る保湿用組成物には、上記必須成分の他に、油性成分，界面活性剤，保湿剤，顔料，紫外線吸収剤，抗酸化剤，香料，防菌防黴剤等の一般的な医薬品及び化粧料用原料や、皮膚細胞賦活剤，美白剤等の生理活性成分をも含有させることができる。 It should be noted that the moisturizing composition according to the present invention is not limited to the above-mentioned essential components, but generally includes oil components, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances, antifungal agents, and the like. Raw materials for pharmaceuticals and cosmetics, and physiologically active ingredients such as skin cell activators and whitening agents.
以下、実施例及び比較例に基づいて本発明をより具体的に説明するが、本発明は以下の
実施例に限定されるものではない。
EXAMPLES Hereinafter, although this invention is demonstrated more concretely based on an Example and a comparative example, this invention is not limited to a following example.
［製造例１〜製造例３０］
表１に示した植物及び菌類各２００ｇを乾燥，粉砕し、５０容量％エタノール水溶液媒各１リットル中にて２０℃で３日間撹拌抽出した後、ろ過してろ液を回収し、製造例１〜製造例３０に係る抽出物を得た。
[Production Example 1 to Production Example 30]
200 g of each of the plants and fungi shown in Table 1 were dried and pulverized, extracted by stirring at 20 ° C. for 3 days in 1 liter of 50% by volume ethanol aqueous solution, and then filtered to collect the filtrate. An extract according to Production Example 30 was obtained.
［実施例１〜３１］
(１)精製水 ９９．０(質量％)
(２)米醗酵液 ０．５
(３)表２に示す成分 ０．５
製法：(１)〜(３)を均一に混合する。
[Examples 1 to 31]
(1) Purified water 99.0 (mass%)
(2) Rice fermentation broth 0.5
(3) Ingredients shown in Table 2 0.5
Production method: (1) to (3) are mixed uniformly.
［比較例１〜３２］
(１)精製水 ９９．０(質量％)
(２)表３に示す成分 １．０
製法：(１)及び(２)を均一に混合する。
[Comparative Examples 1-32]
(1) Purified water 99.0 (mass%)
(2) Ingredients shown in Table 3 1.0
Production method: (1) and (2) are mixed uniformly.
実施例１〜３１及び比較例１〜３２を用いて、保湿効果の測定を行った。実施例若しくは比較例を前腕部、３×４ｃｍ2の範囲に２４μＬずつ塗布し、塗布前、塗布後３０、６０、１２分の角質水分量を測定した。角質水分量は、ＳＫＩＣＯＮ−２００（アイ・ビイ・エス株式会社製）を用い、各塗布部位から５ポイントずつの角質水分量を、測定した。５ポイントの測定値の平均値を角質水分量とし、塗布前の角質水分量を１とした相対値で表４〜６に示した。なお対照として、精製水を塗布し、同様に角質水分量を測定した。対照の角質水分量にばらつきが認められたため、測定毎に対照も同時に測定した。３０分後、６０分後、１２０分後の角質水分量について、比較例と実施例の間で有意差検定を行い、５％の確率で有意差が認められたものは「＊」、１％の確率で有意差が認められたものは「＊＊」を結果に付した。 The moisturizing effect was measured using Examples 1 to 31 and Comparative Examples 1 to 32. The examples or comparative examples were applied to the forearm portion in a range of 3 × 4 cm 2 by 24 μL, and the amount of keratin moisture was measured before application and 30, 60, and 12 minutes after application. The horny water content was measured by using SKICON-200 (manufactured by IBI S Co., Ltd.), and the horny water content at 5 points from each application site was measured. Tables 4 to 6 show the relative values in which the average value of the five-point measurement value is the keratin moisture content and the keratin moisture content before coating is 1. As a control, purified water was applied and the keratin water content was measured in the same manner. Since a variation was found in the amount of stratum corneum water in the control, the control was simultaneously measured for each measurement. For the keratinous water content after 30 minutes, 60 minutes, and 120 minutes, a significant difference test was performed between the comparative example and the example. Those with a significant difference in probability were marked with “**”.
本発明の実施例においては、米醗酵液を単独で二倍量配合した比較例３２より高い保湿効果を示し、その保湿効果は、成分（Ｂ）を単独で２倍量配合した比較例より有意に高いものであった。すなわち、米醗酵液と成分（Ｂ）を併用することにより、保湿効果が相乗的に向上していることは明らかである。 In the examples of the present invention, the moisturizing effect is higher than that of Comparative Example 32 in which the double amount of rice fermentation broth is blended alone, and the moisturizing effect is more significant than the comparative example in which component (B) is blended in double amount alone. It was expensive. That is, it is clear that the moisturizing effect is synergistically improved by using the rice fermentation broth and the component (B) in combination.
本発明の保湿剤を配合した皮膚外用剤の処方例を示す。 The formulation example of the skin external preparation which mix | blended the moisturizer of this invention is shown.
［処方例１］乳液
（１）スクワラン １０．０（質量％）
（２）メチルフェニルポリシロキサン ４．０
（３）水素添加パーム核油 ０．５
（４）水素添加大豆リン脂質 ０．１
（５）モノステアリン酸ポリオキシエチレン
ソルビタン（２０Ｅ．Ｏ．） １．３
（６）モノステアリン酸ソルビタン １．０
（７）グリセリン ４．０
（８）パラオキシ安息香酸メチル ０．１
（９）カルボキシビニルポリマー ０．１５
（10）精製水 ５８．５５
（11）アルギニン（１質量％水溶液） ２０．０
（12）米醗酵液 ０．１
（13）製造例２（コウスイハッカ） ０．０５
（14）製造例５（ビロードアオイ） ０．０５
（15）製造例９（シラカバ） ０．０５
（16）製造例１４（セイヨウニワトコ） ０．０５
製法：（１）〜（６）の油相成分を８０℃にて加熱溶解する。一方（７）〜（10）の水相成分を８０℃にて加熱溶解する。これに前記油相成分を攪拌しながら加え、ホモジナイザーにより均一に乳化する。乳化終了後、冷却を開始し、（11）と（12）〜（16）を順次加え、均一に混合する。
[Formulation Example 1] Emulsion (1) Squalane 10.0 (mass%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 58.55
(11) Arginine (1% by weight aqueous solution) 20.0
(12) Rice fermentation broth 0.1
(13) Production Example 2 (Kousui mint) 0.05
(14) Production Example 5 (velvet aoi) 0.05
(15) Production Example 9 (birch) 0.05
(16) Production Example 14 (Elderberry) 0.05
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification, cooling is started, and (11) and (12) to (16) are sequentially added and mixed uniformly.
［処方例２］化粧水
（１）エタノール １５．０（質量％）
（２）ポリオキシエチレン（４０Ｅ．Ｏ．）硬化ヒマシ油 ０．３
（３）香料 ０．１
（４）精製水 ８３．２８
（５）クエン酸 ０．０２
（６）クエン酸ナトリウム ０．１
（７）グリセリン １．０
（８）ヒドロキシエチルセルロース ０．１
（９）米醗酵液 ０．０５
（10）製造例１８（ナツメ） ０．０１
（11）製造例２３（ムクロジ） ０．０１
（12）製造例２９（ナツノハナワラビ） ０．０１
（13）製造例３（カロット） ０．０１
（14）製造例１１（イチョウ） ０．０１
製法：（１）に（２）及び（３）を溶解する。溶解後、（４）〜（８）を順次添加した後、十分に攪拌し、（９）〜（14）を加え、均一に混合する。
[Prescription Example 2] Lotion (1) Ethanol 15.0 (mass%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 83.28
(5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Rice fermentation liquor 0.05
(10) Production Example 18 (jujube) 0.01
(11) Production Example 23 (Mukuroji) 0.01
(12) Production Example 29 (Natsunohanawarabi) 0.01
(13) Production Example 3 (Carrot) 0.01
(14) Production Example 11 (Ginkgo) 0.01
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then sufficiently stirred, and (9) to (14) are added and mixed uniformly.
［処方例３］クリーム
（１）スクワラン １０．０（質量％）
（２）ステアリン酸 ２．０
（３）水素添加パーム核油 ０．５
（４）水素添加大豆リン脂質 ０．１
（５）セタノール ３．６
（６）親油型モノステアリン酸グリセリン ２．０
（７）グリセリン １０．０
（８）パラオキシ安息香酸メチル ０．１
（９）アルギニン（２０質量％水溶液） １５．０
（10）精製水 ４１．４
（11）カルボキシビニルポリマー（１質量％水溶液） １５．０
（12）米醗酵液 ０．１
（13）製造例１９（シャクヤク） ０．０５
（14）製造例２２（チョウジ） ０．０５
（15）製造例２６（クララ） ０．０５
（16）製造例２９（ナツノハナワラビ） ０．０５
製法：（１）〜（６）の油相成分を８０℃にて加熱溶解する。一方（７）〜（10）の水相成分を８０℃にて加熱溶解する。これに前記油相成分を攪拌しながら加え、ホモジナイザーにより均一に乳化する。乳化終了後、（11）を加え、冷却を開始し、４０℃にて（12）〜（16）を加え、均一に混合する。
[Prescription Example 3] Cream (1) Squalane 10.0 (mass%)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20 mass% aqueous solution) 15.0
(10) Purified water 41.4
(11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Rice fermentation broth 0.1
(13) Production Example 19 (Peonies) 0.05
(14) Production Example 22 (Choji) 0.05
(15) Production Example 26 (Clara) 0.05
(16) Production Example 29 (Natsunohanababi) 0.05
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. (11) is added after completion | finish of emulsification, cooling is started, (12)-(16) is added at 40 degreeC, and it mixes uniformly.
［処方例４］美容液
（１）精製水 ３２．１５(質量％)
（２）グリセリン １０．０
（３）ショ糖脂肪酸エステル １．３
（４）カルボキシビニルポリマー（１質量％水溶液） １７．５
（５）アルギン酸ナトリウム(１質量％水溶液) １５．０
（６）モノラウリン酸ポリグリセリル １．０
（７）マカデミアナッツ油脂肪酸フィトステリル ３．０
（８）N-ラウロイル-L-グルタミン酸
ジ（フィトステリル−２−オクチルドデシル） ２．０
（９）硬化パーム油 ２．０
（10）スクワラン（オリーブ由来） １．０
（11）ベヘニルアルコール ０．７５
（12）ミツロウ １．０
（13）ホホバ油 １．０
（14）１、３−ブチレングリコール １０．０
（15）Ｌ−アルギニン（１０質量％水溶液） ２．０
（16）米醗酵液 ０．２
（17）製造例４（フキタンポポ） ０．０２
（18）製造例７（ハマメリス） ０．０２
（19）製造例１３（ユキノシタ） ０．０２
（20）製造例２１（ノイバラ） ０．０２
（21）α−Ｄ−グルコピラノシルグリセロール ０．０２
製法：（１）〜（６）の水相成分を混合し、７５℃にて加熱溶解する。一方、（７）〜（14）の油相成分を混合し、７５℃にて加熱溶解する。次いで、上記水相成分に油相成分を添加して予備乳化を行った後、ホモミキサーにて均一に乳化する。乳化終了後に冷却を開始し、５０℃にて（15）を加える。さらに４０℃まで冷却し、（16）〜（21）を加え、均一に混合する。
[Prescription Example 4] Cosmetic liquid (1) Purified water 32.15 (mass%)
(2) Glycerin 10.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1% by weight aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by mass aqueous solution) 2.0
(16) Rice fermentation broth 0.2
(17) Production Example 4 (Fukidan Popo) 0.02
(18) Production Example 7 (Hamelis) 0.02
(19) Production Example 13 (Yukinoshita) 0.02
(20) Production Example 21 (Nebara) 0.02
(21) α-D-glucopyranosylglycerol 0.02
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Cooling is started after completion of emulsification, and (15) is added at 50 ° C. Furthermore, it cools to 40 degreeC, (16)-(21) is added, and it mixes uniformly.
［処方例５］水性ジェル
（１）カルボキシビニルポリマー ０．５（質量％）
（２）精製水 ８８．３
（３）水酸化ナトリウム（１０質量％水溶液） ０．５
（４）エタノール １０．０
（５）パラオキシ安息香酸メチル ０．１
（６）香料 ０．１
（７）米醗酵液 ０．３
（８）製造例１（ゲットウ） ０．０５
（９）製造例２０（ブクリョウタケ） ０．０５
（10）製造例１２（ゲンノショウコ） ０．０５
（11）製造例３０（アカキナノキ） ０．０５
製法：（１）を（２）に加え、均一に攪拌した後、（３）を加える。均一に攪拌した後、（４）に予め溶解した（５）を加える。均一に攪拌した後、（６）及び（７）〜（11）を加え、均一に攪拌混合する。
[Formulation Example 5] Aqueous gel (1) Carboxyvinyl polymer 0.5 (mass%)
(2) Purified water 88.3
(3) Sodium hydroxide (10% by mass aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Rice fermentation broth 0.3
(8) Production Example 1 (Getto) 0.05
(9) Production Example 20 (Bukuryotake) 0.05
(10) Production Example 12 (Genko) 0.05
(11) Production Example 30 (red linden) 0.05
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, (6) and (7) to (11) are added and stirred and mixed uniformly.
［処方例６］クレンジング料
（１）スクワラン ８１．５（質量％）
（２）イソステアリン酸ポリオキシエチレングリセリル １５．０
（３）精製水 ３．０
（４）米醗酵液 ０．３
（５）製造例２４（キハダ） ０．１
（６）製造例１２（ゲンノショウコ） ０．１
製法：（１）と（２）を均一に溶解する。これに、（３）と（４）〜（６）を順次加え、均一に混合する。
[Formulation Example 6] Cleansing Fee (1) Squalane 81.5 (mass%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water 3.0
(4) Rice fermentation broth 0.3
(5) Production Example 24 (yellowfin) 0.1
(6) Production Example 12 (Genko) 0.1
Manufacturing method: (1) and (2) are uniformly dissolved. To this, (3) and (4) to (6) are sequentially added and mixed uniformly.
［処方例７］洗顔フォーム
（１）ステアリン酸 １６．０（質量％）
（２）ミリスチン酸 １６．０
（３）親油型モノステアリン酸グリセリン ２．０
（４）グリセリン ２０．０
（５）水酸化ナトリウム ７．５
（６）ヤシ油脂肪酸アミドプロピルベタイン １．０
（７）精製水 ３６．７
（８）米醗酵液 ０．５
（９）製造例８（パセリ） ０．１５
（10）製造例６（タチジャコウソウ） ０．１５
製法：（１）〜（４）の油相成分を８０℃にて加熱溶解する。一方（５）〜（７）の水相成分を８０℃にて加熱溶解し、油相成分と均一に混合撹拌する。冷却を開始し、４０℃にて（８）〜（10）を加え、均一に混合する。
[Formulation Example 7] Face-wash foam (1) Stearic acid 16.0 (mass%)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 20.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Purified water 36.7
(8) Rice fermentation broth 0.5
(9) Production Example 8 (parsley) 0.15
(10) Production Example 6 (Tachimukousou) 0.15
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. Cooling is started, and (8) to (10) are added at 40 ° C. and mixed uniformly.
［処方例８］メイクアップベースクリーム
（１）スクワラン １０．０(質量％)
（２）セタノール ２．０
（３）グリセリントリ−２−エチルヘキサン酸エステル ２．５
（４）親油型モノステアリン酸グリセリル １．０
（５）プロピレングリコール １１．０
（６）ショ糖脂肪酸エステル １．３
（７）精製水 ７０．１
（８）酸化チタン １．０
（９）ベンガラ ０．１
（10）黄酸化鉄 ０．４
（11）香料 ０．１
（12）米醗酵液 ０．３
（13）製造例１０（ブナ） ０．２
製法：（１）〜（４）の油相成分を混合し、７５℃にて加熱溶解する。一方、（５）〜（７）の水相成分を混合し、７５℃にて加熱溶解し、これに（８）〜（10）の顔料を加え、ホモミキサーにて均一に分散させる。この水相成分に前記油相成分を加え、ホモミキサーにて乳化する。乳化終了後に冷却を開始し、４０℃にて（11）と（12）、（13）の成分を加え、均一に混合する。
[Prescription Example 8] Make-up base cream (1) Squalane 10.0 (mass%)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) Purified water 70.1
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Rice fermentation broth 0.3
(13) Production Example 10 (beech) 0.2
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11), (12) and (13) are added at 40 ° C. and mixed uniformly.
［処方例９］乳液状ファンデーション
（１）メチルポリシロキサン ２．０(質量％)
（２）スクワラン ５．０
（３）ミリスチン酸オクチルドデシル ５．０
（４）セタノール １．０
（５）ポリオキシエチレン(２０Ｅ．Ｏ．)
ソルビタンモノステアリン酸エステル １．３
（６）モノステアリン酸ソルビタン ０．７
（７）１、３−ブチレングリコール ８．０
（８）キサンタンガム ０．１
（９）パラオキシ安息香酸メチル ０．１
（10）精製水 ５８．１
（11）酸化チタン ９．０
（12）タルク ７．４
（13）ベンガラ ０．５
（14）黄酸化鉄 １．１
（15）黒酸化鉄 ０．１
（16）香料 ０．１
（17）米醗酵液 ０．３
（18）製造例２５（コガネバナ） ０．２
製法：（１）〜（６）の油相成分を混合し、７５℃にて加熱溶解する。一方、（７）〜（10）の水相成分を混合し、７５℃にて加熱溶解し、これに（11）〜（15）の顔料を加え、ホモミキサーにて均一に分散する。油相成分を加え、乳化を行う。乳化終了後に冷却を開始し、４０℃にて（16）と（17）、（18）の成分を順次加え、均一に混合する。
[Prescription Example 9] Emulsion foundation (1) Methylpolysiloxane 2.0 (mass%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 58.1
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Rice fermentation broth 0.3
(18) Production Example 25 (Koganebana) 0.2
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating at 75 ° C., and the pigments (11) to (15) are added thereto and uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after the emulsification is completed, and components (16), (17) and (18) are sequentially added at 40 ° C. and mixed uniformly.
［処方例１０］油中水型エモリエントクリーム
（１）流動パラフィン ３０．０(質量％)
（２）マイクロクリスタリンワックス ２．０
（３）ワセリン ５．０
（４）ジグリセリンオレイン酸エステル ５．０
（５）塩化ナトリウム １．３
（６）塩化カリウム ０．１
（７）プロピレングリコール ３．０
（８）１、３−ブチレングリコール ５．０
（９）パラオキシ安息香酸メチル ０．１
（10）米醗酵液 ０．５
（11）製造例２７（オドリコソウ） ０．３
（12）製造例２８（スギゴケ） ０．２
（13）精製水 ４７．４
（14）香料 ０．１
製法：（５）と（６）を（13）の一部に溶解して５０℃とし、５０℃に加熱した（４）に撹拌しながら徐々に加える。これを混合した後、７０℃にて加熱溶解した（１）〜（３）に均一に分散する。これに（７）〜（12）を（13）の残部に７０℃にて加熱溶解したものを撹拌しながら加え、ホモミキサーにて乳化する。乳化終了後に冷却を開始し、４０℃にて（14）を加え、均一に混合する。
[Formulation Example 10] Water-in-oil emollient cream (1) Liquid paraffin 30.0 (% by mass)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Rice fermentation broth 0.5
(11) Production Example 27 (Apricot) 0.3
(12) Production Example 28 (Sugigoke) 0.2
(13) Purified water 47.4
(14) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (13) to 50 ° C, and gradually add to (4) heated to 50 ° C with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (12) are added to the remainder of (13) heated and dissolved at 70 ° C. with stirring, and emulsified with a homomixer. Cooling is started after completion of emulsification, and (14) is added at 40 ° C. and mixed uniformly.
［処方例１１］パック
（１）精製水 ６３．２(質量％)
（２）ポリビニルアルコール １２．０
（３）エタノール １７．０
（４）グリセリン ５．０
（５）ポリエチレングリコール（平均分子量１０００） ２．０
（６）米醗酵液 ０．７
（７）製造例１（ゲットウ） ０．１
製法：（２）と（３）を混合し、８０℃に加温した後、８０℃に加温した（１）に溶解する。均一に溶解した後、（４）と（５）を加え、攪拌しながら冷却を開始する。４０℃まで冷却し、（６）と（７）を加え、均一に混合する。
[Prescription Example 11] Pack (1) Purified water 63.2 (mass%)
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 5.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Rice fermentation broth 0.7
(7) Production Example 1 (Getto) 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After uniformly dissolving, add (4) and (5), and start cooling while stirring. Cool to 40 ° C, add (6) and (7) and mix uniformly.
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| JP2010222306A (en) * | 2009-03-24 | 2010-10-07 | Pias Arise Kk | External composition for skin |
| JP4455665B1 (en) * | 2009-08-27 | 2010-04-21 | 株式会社ノエビア | Emulsified cosmetics |
| KR101715200B1 (en) * | 2016-04-26 | 2017-03-10 | (주)아모레퍼시픽 | Composition containing glycoproteins extract from plant |
| JP6277312B1 (en) * | 2017-07-19 | 2018-02-07 | 株式会社ノエビア | Topical skin preparation |
| KR102251190B1 (en) * | 2018-10-11 | 2021-05-14 | (주)카보엑스퍼트 | A composition comprising extract of Syzygium formosum for skin whitening |
| JP2020094000A (en) * | 2018-12-13 | 2020-06-18 | 株式会社ノエビア | Skin external preparation |
| WO2023214953A1 (en) * | 2022-05-05 | 2023-11-09 | Honnes Sağlik Ve Endüstri̇yel Ürünleri̇ Anoni̇m Şi̇rketi̇ | Nipple balm and cosmetic formulations containing encapsulated elderberry seed oil |
| CN117205125B (en) * | 2023-10-27 | 2024-04-02 | 广州果壳生物科技有限公司 | Soapberry fermentation liquor, soapberry fermentation liquor composition and application of soapberry fermentation liquor and soapberry fermentation liquor composition in cosmetics |
| CN120059850B (en) * | 2025-02-27 | 2025-08-15 | 四川省农业特色植物研究院 | Daofu azalea essential oil and preparation method and application thereof |
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