JP3504594B2 - External preparation for skin - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a combination of a plurality of plant extracts, and further comprises one or more fatty acids having 10 to 22 carbon atoms, one or more fatty acid triglycerides, squalane, A skin external preparation made of a combination of beeswax and jojoba oil, easy to adapt to the skin, and capable of exhibiting a high skin moisturizing effect, a beautiful skin effect and a skin roughening improving effect, and the skin external preparation, which is used in combination, How to care for.

[0002]

2. Description of the Related Art Conventionally, extracts of various kinds of plants such as medicinal plants have been used for external preparations for skin (Fragrance Journal, Extra edition No. 1, 1979,
The same magazine, Extra Edition 6, No. 6, 1986). In recent years, with the increasing tendency toward nature and plant protection due to animal welfare, there is an increasing tendency to seek active ingredients in plant extracts.

However, although plant extracts have various actions, their actions are generally not so strong in general, and when an external preparation for skin contains an amount of the plant extract which produces the expected action effect. However, undesired coloring or odor was sometimes observed, or the formulation stability was sometimes lowered. Attempts have been made to enhance the action effect by using a plurality of plant extracts in combination, but various factors are involved in the physiological functions of the skin in a complicated manner. It is difficult to improve the skin condition sufficiently.

[0004]

Therefore, in the present invention, by sufficiently improving the physiological function of the skin, it is possible to exert a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect, and to be compatible with the skin. The aim was to obtain an external preparation for skin which is excellent in formulation stability and safety.

[0005]

[Means for Solving the Problems] As a result of various studies to solve the above problems, as a result of combining an extraction mixture of a specific plant with one or more selected from a specific plant group,
Further, by containing one or more kinds of fatty acids having 10 to 22 carbon atoms, one or more kinds of fatty acid triglycerides, squalane, beeswax and jojoba oil in combination, good results can be obtained. They have found the present invention and completed the present invention.

That is, the external preparation for skin according to the present invention includes
The following (A) and (B), (C) and (D), (E) and (F), and (G) and (H): (A) Chamomile ( Matricaria chamomilla L.), Fennel ( Foeniculum ) vulgare Miller), hops ( Humulus
lupulus L.), yarrow ( Achillea mill)
efolium L.), Melissa ( Melissa officinalis L.) and mistletoe ( Viscum coloratum Nakai var. lutescens)
Miyabe et Kudo or Viscum album L. var. Lutescens M
extraction mixture of akino); (B) horse chestnut (Aesculus turbinata Blume), horse chestnut (Aesculus hippocastanum L.), carrot (Daucus carota L.), rosemary (Rosmarinus off
icinalis L.), Calendula officinal
is L.), Calendula arvensis L., Cornflower ( Centaurea cyanus L.), Horsetail ( Equisetum )
arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyp
tus spp.), plants belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis )
sativus L.), coltsfoot ( Tussilago farfara )
L.), Birodo aoi ( Althaea officinalis L.), plants belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of
ficinalis var. tenuior ), Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.), Thymus vulgaris
L.), Tormentilla ( Potentilla tormentilla ), Fern ( Glycyrrhiza uralensis Fisher, Glycyrrhiza)
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. et Herd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum cris
pum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) 1 or 2 selected from the plant group consisting of
(C) Extraction mixture of fennel ( Foeniculum vulgare Miller), horse chestnut ( Aesculus turbinata Blume) and / or horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.); (D) chamomile (C) Matricaria chamomilla L.), hops ( Humulus lupulus L.), yarrow ( Achi )
llea millefolium L.), Melissa officinal
is L.), mistletoe ( Viscum coloratum Nakai var. lut
escens Miyabe et Kudo or Viscum album L. var. lute
scens Makino), Mannenrou ( Rosmarinus officinal )
is L.), Calendula officinalis
L.), Calendula arvensis L., Cornflower ( Centaurea cyanus L.), Horsetail ( Equisetum a )
rvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptu)
s spp.), plants belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis s )
ativus L.), coltsfoot ( Tussilago farfara )
L.), Birodo aoi ( Althaea officinalis L.), plants belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of
ficinalis var. tenuior ), Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.), Thymus vulgaris
L.), Tormentilla ( Potentilla tormentilla ), Fern ( Glycyrrhiza uralensis Fisher, Glycyrrhiza)
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. etHerd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum cris
pum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) 1 or 2 selected from the plant group consisting of
(E) Chamomile ( Matricaria chamomilla L.), yarrow ( Achillea millefolium L.), one or two of the plants belonging to the genus Hypericum ( Hypericum spp.)
Species and above, coltsfoot ( Tussilago farfara L.), velour's mallow ( Althaea officinalis L.), salvia ( Sa
lvia officinalis L.) and / or its variants ( Salvia of
Ficinalis var. tenuior ) extraction mixture; (F) Fennel ( Foeniculum vulgare Miller), hops ( Humulus lupulus L.), Melissa offi
cinalis L.), mistletoe ( Viscum coloratum Nakai va
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino), Aesculus turbinat
a Blume), Horse chestnut ( Aesculus hippocastanu
m L.), carrots ( Daucus carota L.), mannose wax ( Rosmarinus officinalis L.), Calendula officinalis ( Cal )
endula officinalis L.), Calendula (Calendula arv
ensis L.), cornflower ( Centaurea cyanus L.),
Horsetail ( Equisetum arvense L.), plant belonging to the genus Eucalyptus ( Eucalyptus spp.), Plant belonging to the genus Aloe ( Aloe spp.), Quince ( Cydonia oblonga Mill.),
Cucumber (Cucumis sativus L.), Hamamelis (Hamame
lis virginiana L.), hawthorn ( Hamemelis japonica )
Sieb. Et Zucc.), Thymus vulgari
s L.), Tormentilla ( Potentilla tormentilla ),
Glycyrrhiza uralensis Fisher, Glycyrrhiz
a glabra L. and its variants, Glycyrrhiza echinata L.,
Glycyrrhiza glandulifera Reg. Et Herd.), Plants belonging to the genus Lily ( Lilium spp.), Parsley ( Petroselinum cr )
ispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Be
tula spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.) Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemis
nobilis L.) 1, two or more extracts selected from the group of plants consisting of;. (G) Salvia (Salvia officinalis L.) and / or its variants (Salvia officinalis var tenuior), Hamamelis (Hamamelis virginiana L. ), Tati thyme (Thymus vulgaris L.), Torumentira (Potentil
la tormentilla ), Mannenrou ( Rosmarinus officin
alis L.) extraction mixture; (H) chamomile ( Matricaria chamomilla L.), fennel ( foeniculum vulgare Miller), hops ( Humulus )
lupulus L.), yarrow ( Achillea mill)
efolium L.), Melissa officinalis L.),
Mistletoe ( Viscum coloratum Nakai var. Lutescens Mi
yabe et Kudo or Viscum album L. var. lutescens Mak
ino), Horse chestnut ( Aesculus turbinata Blume), Horse chestnut ( Aesculus hippocastanum L.), Carrot ( Daucus carota L.), Calendula ( Calendula )
officinalis L.), Calendula arvensis
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), Plants belonging to the genus Aloe ( Aloe)
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago )
farfara L.), Below Aoi ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.
p.), witch hazel (Hamamelis japonica Sieb. et Zuc
c.), licorice ( Glycyrrhiza uralensis Fisher, Glyc
yrrhiza glabra L. and its variants, Glycyrrhiza echinat
a L., Glycyrrhiza glandulifera Reg. et Herd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroseli
num crispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo
biloba L.), Wolverine ( Hedera tobleri Nakai), Western Wolverine ( Hedera helix L.) and Roman chamomile ( A )
nthemis nobilis L.) one or two or more kinds of extracts selected from the group of plants; and a plant extract consisting of a combination of any one of them and one of fatty acids having 10 to 22 carbon atoms.
One or more kinds, one or more kinds of fatty acid triglycerides, squalane, beeswax and jojoba oil are contained, respectively.

Further, in the present invention, the skin condition can be further improved by using a combination of two or more of the above-mentioned external preparations for skin.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extraction mixture (A) used in the present invention is chamomile ( Matricaria chamomilla).
L.), fennel ( Foeniculum vulgare Miller), hops ( Humulus lupulus L.), yarrow ( Achillea millefolium L.), melissa ( Melissa off )
icinalis L.) and mistletoe ( Viscum coloratum Nakai
var.lutescens Miyabe et Kudo or Viscum album L. v
ar. lutescens Makino).

The chamomile ( Matricaria chamomilla L.) is an annual or perennial plant belonging to the family Asteraceae ( Compositae ), and is a basic plant of the herbal medicine "Chamomillae Flos ". Each part of leaves, stems, roots, head flowers and the like and the whole plant can be used, but it is preferable to use head flowers.

Foeniculum vulgare Mille
r) is a perennial plant belonging to the Umbelliferae family and is the base plant of the herb medicine " Foeniculi Fructus ". Leaves, stems, roots, flowers, fruits and other parts and whole plants can be used. Preference is given to using fruits.

[0011] Hop ( Humulus lupulus L.) is a dioecious vine perennial belonging to the Moraceae family, and is a base plant of the herbal medicine " Lupuli Strobilus ".
Each part of leaves, stems, roots, flowers and the like and the whole plant can be used, but it is preferable to use female spikes.

[0012] Achillea millefo
lium L.) is a perennial plant belonging to the family Asteraceae ( Compositae ),
Each part of leaves, stems, roots, flowers and the like can be used, but it is preferable to use flowers or whole plants.

[0013] Melissa (Melissa officinalis L.) is a perennial plant belonging to the Labiatae (Labiatae), leaves, stems, roots, it is possible to use the site and the whole plant flowers, etc., it is preferable to use a leaf.

Mistletoe ( Viscum coloratum Nakai var.
lutescens Miyabe et Kudo or Visc um album L. var. l
utescens Makino) is a dioecious evergreen semi-parasitic shrub belonging to the family Mistletoe ( Loranthaceae ). It can use leaves, branches, flowers, fruits, seeds, etc. It is preferable to use.

The above-mentioned 6 kinds of plants may be subjected to extraction at the same time, but they may be extracted individually and then the obtained extracts may be mixed. In addition, "MS Extract (Complex VII)" (Maruzen Pharmaceutical Co., Ltd.), "Sefplant Complex" (Kurrichter Co., Ltd.)
It is also possible to use a commercially available product such as.

In the present invention, each plant constituting the plant group (B) used in combination with the extraction mixture (A) will be described below.

Horse chestnut ( Aesculus turbinata Blume) and horse chestnut ( Aesculus hippocastanum L.) are deciduous trees belonging to the horse chestnut family ( Hippocastanaceae ).
Each part of leaves, branches, bark, flowers, fruits and the like and whole trees can be used, but it is preferable to use leaves, bark or fruits.

The carrot ( Daucus carota L.) is a perennial herb belonging to the family Umbelliferae ( Umbelliferae ), and it is possible to use each part of leaves, stems, roots and the whole plant, but it is preferable to use the root part.

Mannen roe ( Rosmarinus officinalis
L.) is an evergreen shrub belonging to Labiatae and has leaves,
Each part of the branch, bark, flower, etc. and the whole tree can be used, but it is preferable to use leaves.

Calendula officinalis
L.) and Calendula arvensis L. are first- and second-year herbs belonging to the Asteraceae ( Compositae ) family.
Each part of leaves, stems, flowers, roots, and the whole plant can be used, but it is preferable to use flowers.

Cornflower ( Centaurea cyanus L.) is an annual plant belonging to the family Asteraceae ( Compositae ), and includes leaves, stems, flowers,
Although various parts such as roots and whole plants can be used, it is preferable to use flowers.

Horsetail ( Equisetum arvense L.) is a perennial fern plant belonging to the family Equisetaceae , and it is possible to use all parts of rhizomes, spores, vegetative stems and whole plants, but it is preferable to use whole plants. .

Examples of the plant belonging to the genus Eucalyptus include Eucalyptus globulus Labill. And its related plants. These are the family of Myrtacaceae ( Myrtacaceae).
eae ), an evergreen tree, which is a crude drug "eucalyptus oil"
( Oleum Eucalypti ) is the basic plant. Related plants include Eucalyptus polybractea RTBaker, Eucalyptus
dives Schauer. In addition, lemon eucalyptus ( Eucalyptus citriodora Hook.), Eucalyptus piperi
ta Sm., Eucalyptus gunnii Hook. fil., Eucalyptus m
acarthuri Decne. Et Maiden, Eucalyptus rostrata Sc
hlecht., Eucalyptus staigeriana FvM and the like can also be used, and one kind or two or more kinds are selected from these and used for extraction. Each part of leaves, branches, bark, flowers, fruits and the like and whole trees can be used, but it is preferable to use leaves.

A plant belonging to the genus Aloe is a lily family (Liliacea
e) Is a woody succulent plant belonging toAlo
e) Is used as a base plant.Aloe ferox Mill.,A
loe africana Mill.,Aloe spicata Baker,Aloe arbor
escens Mill.,Aloe succotrina Lam.,Aloe plicatili
s Mill.,Aloe bainesii Th.Dyer.,Aloe marlothii Bg
r.,Aloe perryi Baker,Aloe vera L.,Aloe barbaden
sis Mill. And Kidachi Aloe (Aloe arborescens Mill.
var.natalensis Berg.) Etc., and from these 1
One kind or two or more kinds are selected and used. Leaves, flowers for extraction
Each part of stems, flowers, etc. and whole plants can be used, but leaves
It is preferable to use parts.

Quince ( Cydonia oblonga Mill.) Is a deciduous tree belonging to the family Rosaceae and has leaves, branches, bark,
Although it is possible to use all parts of flowers, fruits, etc. and whole trees,
Preference is given to using leaves or fruits.

Cucumber ( Cucumis sativus L.) is an annual vine plant belonging to the family Cucurbitaceae and has leaves, stems,
Although it is possible to use each part of flowers, fruits, etc. and whole grass,
Preference is given to using fruits.

The coltsfoot ( Tussilago farfara L.) is a perennial herb belonging to the family Asteraceae ( Compositae ).
Each site such as flowers and roots and whole plants can be used, but leaves or flowers are preferably used.

Bellows Aoi ( Althaea officinalis
L.) is a perennial plant belonging to the Malvaceae family.
Although various parts such as stems, flowers, and roots and whole plants can be used, it is preferable to use leaves or roots.

[0029] Examples of the plants belonging to the genus Hypericum, St. John's wort (Hypericum erectum Thunb.), Hypericum perforatum L., Tomoesou (Hyper to be produced in Europe
icumascyron L.) and these are Hypericumaceae ( Gu
ttiferae ) is a perennial herb that is used alone or in combination of two or more. Each part of leaves, stems, flowers, roots, and the whole plant can be used for the extraction, but it is preferable to use the whole plant.

Salvia ( Salvia officinalis L.) and its variant Salvia officinalis var. Tenuior are perennial plants belonging to Labiatae ( Labiatae ) and can be used for all parts of leaves, stems, flowers, roots and whole plants. However, it is preferable to use leaves.

Hamamelis virginiana L.
And Hamamelis japonica Sieb. Et Zucc. Are deciduous trees belonging to the family Hamamelidaceae .
Each part of the branch, bark, flower, etc. and the whole tree can be used, but it is preferable to use leaves.

Thymus vulgaris L.
Is an evergreen small shrub belonging to Labiatae , with leaves,
Although various parts such as stems, flowers and roots and whole plants can be used, it is preferable to use whole plants.

Tormentilla (Potentilla tormentill
a) Is a rose family (Rosaceae) Is a perennial herb belonging to
Each part of stems, flowers, roots and whole plants can be used
However, it is preferable to use roots.

Glycyrrhiza uralensis Fishe
r, Glycyrrhiza glabra L. and its variants, Glycyrrhiza
echinata L., Glycyrrhiza glandulifera Reg. et Her
d.) is a perennial plant belonging to the leguminous family ( Leguminosae ), and is a basic plant of the herb " Glycyrrhizae Radix ". A variant of Glycyrrhiza glabra L. is Glycyrrhi.
za glabra var.typica Regel et Herder, Glycyrrhiza
glabra var. violacea Boiss., Glycyrrhiza glabra va
r. pallida Boiss. 1 or 2 from the above
Select and use at least one species. For extraction, each part of leaves, stems, flowers, roots and the whole plant can be used, but it is preferable to use roots.

[0035] The plant belonging to the lily genus, gold-banded lily (Lili
um auratum Lindl.), Madonna Lily ( Lilium candid)
um L.), Himeyuri (Lilium concolor Salisb.), L. formosanum (Lilium formosanum Wallace), Sasayuri (L
ilium japonicum Thunb. ex Houtt.), Lili
um lancifolium Thunb.), Lilium leicht
linii Hook. f. var. maximowiczii Baker), Teppo lily ( Lilium longiflorum Thunb.), Iwato lily ( Lil
ium maculatum Thunb.), Lilium medeolo
ides A. Gray), Lilium regale Wil
s.), Otomeyuri (Lilium rebellum Baker), Lilium speciosum (Lilium speciosum Thunb.), and the like. These are perennials belonging to the family Liliaceae , and one or more species are selected and used. For extraction, each part of leaves, stems, flowers, stems and the like and whole plants can be used, but it is preferable to use stems.

Parsley ( Petroselinum crispum (Mill.) N
ym. ex AWHill.) is a perennial or perennial plant belonging to the family Apiaceae ( Umbelliferae ), and can be used for all parts of leaves, stems, flowers, fruits and the like, but it is preferable to use leaves and stems. .

The plants belonging to the genus Tilia include Tilia americana L. and Tili
a cordata Mill.), Tilia europae
a L.), linden (Tilia japonica Simonk.), Heranoki (Tilia kiusiana Makinoet Shiras.), Oba linden (Tilia maximowicziana Shiras.), linden (Tilia miqueliana Maxim.), Natsu linden (Tilia
platyphyllos Scop.) etc. These are deciduous trees belonging to the family Tiliaceae , one or two.
Select and use at least one species. For extraction, leaves, branches, bark,
Although it is possible to use all parts of flowers, fruits, etc. and whole trees,
Preference is given to using flowers or fruits.

Plants belonging to the genus Birch include Betula ermanii Cham. And Betula grossa Si.
eb. et Zucc.), sweet birch ( Betula lenta)
L.), Betula maximowicziana Rege
l), red birch ( Betula nigra L.), paper birch ( Betula papyrifera Marsh.), silver birch ( Be
tula pendula Roth.), birch ( Betula platyphylla )
Sukatchev var. Japonica Hara.), European birch ( Betula pubescens Ehrh,), Ono ore birch ( Betu
la schmidtii Regel), Himalayan Paper Birch ( Betu
la utilis D.Don) etc. These are birch ( Bet
ulaceae ) deciduous shrubs or trees, and one or more species selected and used. For extraction, each part of leaves, branches, bark, flowers, fruits, etc. and whole trees can be used, but it is preferable to use leaves or bark.

The beech (Fagus crenata Blume) and Fagus japonica (Fagus japonica Maxim.) Is a deciduous tree belonging to the beech family (Fagaceae), it is possible to use leaves, branches, bark, flowers, each site and all the trees of fruit, etc. However, it is preferable to use leaves, bark, or shoots.

Ginkgo biloba L. is a dioecious deciduous tree belonging to the Ginkgoaceae family.
Each part of leaves, branches, bark, flowers, seeds, and the whole tree can be used, but it is preferable to use leaves or seeds.

[0041] ivy (Hedera tobleri Nakai) and ivy (Hedera helix L.) is Araliaceae (Araliacea
The evergreen vines belonging to e ) can be used for each part of leaves, stems, flowers, berries, and whole plants, but it is preferable to use leaves and stems.

Roman chamomile ( Anthemis nobilis L.)
Is a perennial plant belonging to the family Asteraceae ( Compositae ).
Each part of flowers, roots, etc. and whole plants can be used, but it is preferable to use flowers.

Next, the plant extraction mixture of (C) is fennel ( Foeniculum vulgare Miller), horse chestnut ( Aescu
lus turbinata Blume) and / or horse chestnut ( A
esculus hippocastanum L.), carrot ( Daucus carot
a L.) each plant. These plants may be subjected to extraction at the same time, or may be extracted individually and then the obtained extracts may be mixed. Further, commercially available products such as "MS Extract (Complex X)" (manufactured by Maruzen Pharmaceutical Co., Ltd.) and "Chess Plant Complex" (manufactured by Kurtrichter Co., Ltd.) can also be used.

The plant group of (D) used in combination with the plant extraction mixture of (C) is chamomile ( Matricaria chamomilla).
L.), hops ( Humulus lupulus L.), yarrow ( Achillea millefolium L.), melissa ( Melis )
sa officinalis L.), mistletoe ( Viscum coloratum Na
kai var. lutescens Miyabe et Kudo or Viscum album
L. var. Lutescens Makino), Mannenrou ( Rosmarin )
us officinalis L.), Calendula off
icinalis L.), Calendula arvensis
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), Plants belonging to the genus Aloe ( Aloe)
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago )
farfara L.), Below Aoi ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.
p.), salvia (Salvia officinalis L.) and its variants (Salvia officinalis var. tenuior), Hamamelis (Hamamelis virginiana L.), witch hazel (Hamamelis j
aponica Sieb. et Zucc.), Thymus
vulgaris L.), Tormentilla ( Potentilla torment )
illa ), licorice ( Glycyrrhiza uralensis Fisher, Gl
ycyrrhiza glabra L. and its variants, Glycyrrhiza echin
ata L., Glycyrrhiza glandulifera Reg. et Herd.),
Plants belonging to the genus Lily ( Lilium spp.), Parsley ( Petrose
linum crispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume),
Dog beech ( Fagus japonica Maxim.), Ginkgo ( Ginkg )
o biloba L.), Wolverine ( Hedera tobleri Nakai), Western Wolverine ( Hedera helix L.) and Roman chamomile ( A )
nthemis nobilis L.).

In addition, the plant extraction mixture of (E) is one or more kinds of chamomile ( Matricaria chamomilla L.), Achillea millefolium L., a plant belonging to the genus Hypericum ( Hypericum spp.), And coltsfoot ( Tussilago farfara L.), Below aloe ( Althaea officinalis L.), Salvia offic
inalis L.) and / or its variants ( Salvia officinalis
var. tenuior ) plants. These plants may be subjected to extraction at the same time, or may be extracted individually and then the obtained extracts may be mixed. Further, commercially available products such as "mixed plant extract (12)" (manufactured by Maruzen Pharmaceutical Co., Ltd.) can also be used.

The plant group of (F) used in combination with the plant extraction mixture of (E) is fennel ( Foeniculum vulgare M
iller), hops ( Humulus lupulus L.), Melissa ( M
elissa officinalis L.), mistletoe ( Viscum coloratu
m Nakai var. lutescens Miyabe et Kudo or Viscum al
bum L. var. lutescens Makino), horse chestnut ( Aesculus
turbinata Blume), Horse chestnut ( Aesculus hip)
pocastanum L.), carrot ( Daucus carota L.), mannose wax ( Rosmarinus officinalis L.), eucalyptus ( Calendula officinalis L.), calendula ( Ca
lendula arvensis L.), Cornflower ( Centaurea cya )
nus L.), horsetail ( Equisetum arvense L.), plant belonging to the genus Eucalyptus ( Eucalyptus spp.), plant belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga )
Mill.), Cucumber ( Cucumis sativus L.), Hamamelis virginiana L., witch hazel ( Hamemelis )
japonica Sieb. et Zucc.), Thym
us vulgaris L.), Tormentilla ( Potentilla torme )
ntilla ), licorice ( Glycyrrhiza uralensis Fisher,
Glycyrrhiza glabra L. and its variants, Glycyrrhiza ech
inata L., Glycyrrhiza glandulifera Reg. et Her
d.), plants belonging to the genus Lily ( Lilium spp.), parsley ( P
etroselinum crispum (Mill.) Nym. Ex AWHill.),
Plants belonging to the genus Tilia ( Tilia spp.), Plants belonging to the genus Birch ( Betula spp.), Beech ( Fagus crenata Blu)
me), Fagus japonica (Fagus japonica Maxim.), ginkgo (Ginkgo biloba L.), ivy (Hedera tobleri Naka
i), constituted by ivy (Hedera helix L.) and Roman chamomile (Anthemis nobilis L.).

Furthermore, the plant extraction mixture of (G) comprises salvia ( Salvia officinalis L.) and / or its variants ( S
alvia officinalis var. tenuior ), Hama Melis ( Hama
melis virginiana L.), Thymus vu
lgaris L.), Tormentilla ( Potentillatormentill )
a ) and mannen wax ( Rosmarinus officinalis L.) plants. These plants may be subjected to extraction at the same time, or may be extracted individually and then the obtained extracts may be mixed. Further, commercially available products such as "MS extract (Complex XVI)" (manufactured by Maruzen Pharmaceutical Co., Ltd.) can also be used.

The plant group of (H) used in combination with the plant extraction mixture of (G) is chamomile ( Matricaria chamomilla).
L.), fennel ( Foeniculum vulgare Miller), hops ( Humulus lupulus L.), yarrow ( Achillea millefolium L.), melissa ( Melissa off )
icinalis L.), mistletoe ( Viscum coloratum Nakai va
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino), Aesculus turbinat
a Blume), Horse chestnut ( Aesculus hippocastanu
m L.), carrot ( Daucus carota L.), eucalyptus ( Calendula officinalis L.), calendula ( Calend )
ula arvensis L.), Cornflower ( Centaurea cyanus )
L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), Plants belonging to the genus Aloe ( Aloe spp.), Quince ( Cydonia oblonga Mil)
l.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago farfara L.), billooed aoi ( Althaea )
officinalis L.), a plant belonging to the genus Hypericum ( Hyp
ricum spp.), witch hazel (Hamamelis japonica Sieb. e
t Zucc.), licorice ( Glycyrrhiza uralensis Fishe
r, Glycyrrhiza glabra L. and its variants, Glycyrrhiza
echinata L., Glycyrrhiza glandulifera Reg. et Her
d.), plants belonging to the genus Lily ( Lilium spp.), parsley ( P
etroselinum crispum (Mill.) Nym. Ex AWHill.),
Plants belonging to the genus Tilia ( Tilia spp.), Plants belonging to the genus Birch ( Betula spp.), Beech ( Fagus crenata Blu)
me), Fagus japonica (Fagus japonica Maxim.), ginkgo (Ginkgo biloba L.), ivy (Hedera tobleri Naka
i), constituted by ivy (Hedera helix L.) and Roman chamomile (Anthemis nobilis L.).

In the present invention, the plants constituting the above (A) to (H) may be subjected to extraction as they are, but considering extraction efficiency, they were subjected to treatments such as shredding, drying and crushing. It is preferable to carry out the extraction later. The extraction is performed by immersing it in an extraction solvent. It may be stirred or homogenized in an extraction solvent in order to improve the extraction efficiency. The extraction temperature is 5
It is suitable to set the temperature at about 0 ° C to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is suitable to be about 4 hours to 14 days.

As the extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate. It is possible to use polar organic solvents such as acetone, ketones such as ethyl methyl ketone, etc., and one kind or two or more kinds are selected from these and used. Alternatively, physiological saline, phosphate buffer, phosphate buffered saline, etc. may be used.

The extract of each plant constituting the above (A) to (H) with the above solvent can be contained as it is in the external preparation for skin according to the present invention. It may be used after being redissolved in a polar solvent, or subjected to purification treatment such as decolorization, deodorization, and desalting within a range that does not impair their skin physiological function-improving action, or fractionation treatment by column chromatography. . For storage, it can be used after being purified and then freeze-dried and dissolved in a solvent before use. It can also be used by encapsulating it in vesicles such as liposomes or in microcapsules.

In each of the above inventions, each combination of the above plant extracts has 10 carbon atoms.
~ 22 kinds of fatty acid, 1 kind or 2 kinds or more of fatty acid triglyceride, squalane, beeswax and jojoba oil are used.

Examples of fatty acids having 10 to 22 carbon atoms include decanoic acid (capric acid), undecanoic acid, dodecanoic acid (lauric acid), tetradecanoic acid (myristic acid), pentadecanoic acid, hexadecanoic acid (palmitic acid), heptadecanoic acid. (Margaric acid), octadecanoic acid (stearic acid), eicosanoic acid (arachidic acid), docosanoic acid (behenic acid) and other straight chain saturated fatty acids, 9-decenoic acid (caproleic acid), 9-undecenoic acid (9-undecylenic acid) ), 10-undecenoic acid (10-undecylenic acid), 2-dodecenoic acid (2-lauroleic acid), 5-dodecenoic acid (5-lauroleic acid),
11-dodecenoic acid (11-lauroleic acid), 5-tetradecenoic acid (5-myristoleic acid), 9-tetradecenoic acid (9-myristoleic acid), 2-hexadecenoic acid (2-palmitoleic acid), cis-7- Hexadecenoic acid (7-palmitoleic acid),
cis-6-octadecenoic acid (petroselinic acid), trans-6-octadecenoic acid (petrosecelaidic acid), cis-9-octadecenoic acid (oleic acid), trans-9-octadecenoic acid (elaidic acid), cis-13- Docosenoic acid (erucic acid), trans
-13-Linear monoenoic acids such as docosenoic acid (brassic acid), ci
s-9-, cis-12-octadecadienoic acid (linoleic acid), tran
Dienoic acids such as s-9-, trans-12-octadecadienoic acid (linoelaidic acid), cis-9, cis-12, cis-15-octadecatrienoic acid (linolenic acid), trans-9, trans- 12, trans-15-
Trienoic acid such as octadecatrienoic acid (linolenic elaidic acid), fatty acid having a branched chain such as isopalmitic acid and isostearic acid, and the like can be used, and commercially available raw materials for cosmetics and pharmaceuticals can be used.
In the present invention, one kind or two or more kinds are selected from these and used.

The fatty acid triglycerides used in the present invention include glyceryl triacetylhydroxystearate, glyceryl triacetylricinoleate, glyceryl triisostearate, glyceryl triundecanoate, glyceryl trihydroxystearate, glyceryl tri-2-ethylhexanoate, and trio. Glyceryl oleate, tri (capryl / caprin / isostearin / adipic acid) glyceryl, tri (capryl / capric acid) glyceryl, tri (capryl / caprin / myristin / stearic acid) glyceryl, tri (capryl / caprin / lauric acid) glyceryl, Tri (capryl / caprin / linoleic acid) glyceryl, glyceryl tricaprylate, glyceryl tricaprate, tricery tallow fatty acid glyceryl, tri
(Beef tallow fatty acid, mink oil fatty acid, cod liver oil fatty acid) Glyceryl, glyceryl tristearate, glyceryl tripalmitate, glyceryl tri-2-heptylundecanoate,
Glyceryl tribehenate, glyceryl trimyristate, tri (mink oil fatty acid / palmitic acid) glyceryl,
Tri-coconut oil fatty acid glyceryl, trilauric acid glyceryl, trilanoline fatty acid glyceryl, tri (ricinolein, capron, capryl, capric acid) glyceryl, trilinoleic acid glyceryl, etc. are used. Use commercially available raw materials for cosmetics and pharmaceuticals. You can In the present invention, one kind or two or more kinds are selected from these and used.

Squalane is 2,6,10,15,19,23-hexamethyltetracosane, which can be used as a raw material for cosmetics and pharmaceuticals on the market, but can be used for squalene extracted from deep sea shark liver and olive fruits. Those obtained by hydrogenation can be preferably used.

Beeswax is a honeybee ( Apis indica)
Radoszkowski), European honeybee ( Apis mellifera)
L.) and other honey bee secretions, which are produced by boiling the nest excluding honey and separating and separating the crude wax, which is then chemically or sunlight-purified and bleached. In the present invention, it is preferable to use a deodorized, purified product or ultra-purified product which is commercially available as a raw material for cosmetics and pharmaceuticals.

Jojoba oil is a product of jojoba ( Simmondsia chinens).
Liquid wax extracted from is or Simmondsia californica Nuttall) seeds. Commercially available products can be used as raw materials for cosmetics and pharmaceuticals.

In the present invention, the above-mentioned carbon number of 10 to 10
One or more of 22 fatty acids, one or more of fatty acid triglycerides, squalane, beeswax and jojoba oil are contained as essential oily components. The blending amount and the blending amount ratio in the total amount of these oily components can be appropriately determined depending on the dosage form of the skin external preparation.

The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin cosmetics such as lotion, emulsion, cream, beauty essence, pack,
Makeup base lotion, base cosmetics such as makeup base cream, foundation of each dosage form such as milky liquid, oily, solid, etc., makeup cosmetics such as eye color, cheek color, cleansing cream, cleansing lotion, cleansing foam , It can also be provided as a skin cleansing agent such as face wash soap and body shampoo, and a hair cosmetic such as hair shampoo, hair rinse and hair treatment.

The external preparation for skin according to the present invention includes the plant extracts of the above groups (A) to (H) and the carbon number of 10 to 22.
One or more kinds of fatty acids, one or more kinds of fatty acid triglycerides, squalane, beeswax and jojoba oil, other oily ingredients, surfactants, humectants, pigments, UV absorbers, antioxidants It may also contain general raw materials for pharmaceuticals and cosmetics such as agents, fragrances, antibacterial and antifungal agents, and physiologically active ingredients such as skin cell activating agents, anti-inflammatory agents, and whitening agents.

Further, in another aspect of the present invention, there is provided a skin care method characterized by selecting two or more kinds from the above-mentioned external preparation for skin according to the present application and using them in combination. By such a skin care method, the physiological functions of the skin are synergistically and comprehensively improved, the skin condition is improved, and the skin is kept healthier. The external preparation for skin can be arbitrarily selected, but one or more skin cosmetics and one or more skin cleansing agents, one or more skin cosmetics and one or more base cosmetics, and / or makeup are used. It is preferable to use one or more types of up cosmetics or a combination of the above and one or more types of skin cleansing agents.

[0062]

EXAMPLES The features of the present invention will be described in detail with reference to Examples. First, a preparation example of each plant extract used in the present invention is shown below.

[Plant Extraction Mixture 1] Chamomile ( Matricar
ia chamomilla L.) flowers, fennel (Foeniculum vul
gare Miller) fruit, hops ( Humulus lupulus L.)
Female spikelets, Achillea millefoli
um L.) flowers, Melissa officinalis L. leaves, and mistletoe ( Viscum coloratum Nakai var. lute)
scens Miyabe et Kudo or Viscum album L. var. lutes
cens Makino) each 200g fruit is dried and crushed to 50
3% at 20 ° C in 1 liter of each volume% ethanol solution
After stirring and extracting for one day, the mixture was filtered to collect the filtrate, which was mixed in the same volume to obtain a plant extraction mixture 1.

[Plant Extraction Mixture 2] Fennel ( Foenic
ulum vulgare Miller) fruit, Horse Chestnut ( Aes)
culus hippocastanum L.) bark and carrot ( Daucus
150 g of each root of carota L.) is dried and crushed, and a mixture of ethanol and 1,3-butylene glycol (volume ratio = 1: 1)
After leaving still in 2.5 liters at room temperature for 5 days, it filtered and the filtrate was collect | recovered and it was set as the plant extraction mixture 2.

[Plant Extraction Mixture 3] Chamomile ( Matricar
200 g of ia chamomilla L.) flowers, 200 g of Achillea millefolium L. flowers, 225 g of Tussilago farfara L. flowers, and 180 g of roots of vellum aoi ( Althaea officinalis L.) are dried and crushed. After leaving still in 3 liters of 3,3-butylene glycol at room temperature for 5 days, the filtrate is collected by filtration.
On the other hand, 220 g of the whole plant of Hypericum erectum Thunb. And 300 g of the leaves of Salvia officinalis L. were homogenized in 2.5 liters of a 50 vol% aqueous ethanol solution at 15 ° C., extracted with stirring for 24 hours, and then centrifuged. After that, the supernatant is filtered to collect the filtrate. This filtrate and the above-mentioned filtrate were mixed at a volume ratio of 2: 1 to obtain a plant extraction mixture 3.

[0066] [plant extract mixture 4] salvia (Salvia o
fficinalis L.) leaves 250 g, Hamamelis
virginiana L.) leaves 250 g, pearl millet ( Th
Ymus vulgaris whole plant 300g of L.), root 250g of Torumentira (Potentilla tormentilla), dried leaves 280g of rosemary (Rosmarinus officinalis L.), and triturated at 15 ℃ with ethanol 2 liters of 7
It was left standing for a day for extraction. The filtrate was collected by filtration, concentrated to dryness, and then dissolved in 500 ml of 50% by volume ethanol to obtain a plant extraction mixture 4.

Next, for the plants shown in Table 1, 250 g of each site shown in Table 1 was dried and crushed, and allowed to stand in room temperature for 5 days in 1.5 liters of the solvent shown in Table 1 and then filtered. The liquid was collected and used as an extract of each plant.

[0068]

[Table 1]

For the plants shown in Table 2, 200 g of each part shown in Table 2 was cut into small pieces and the solvent 1 shown in Table 2 was used.
After stirring and extracting in liter at 20 ° C. for 3 days and filtering,
The filtrate was concentrated to 1/3 volume to obtain an extract of each plant.

[0070]

[Table 2]

Subsequently, with respect to the plants shown in Table 3, 230 g of each part shown in Table 3 was finely crushed and crushed, extracted with 1 liter of the solvent shown in Table 3 at 20 ° C. for 3 days with stirring, and filtered to obtain a back solution. It was concentrated to dryness and then freeze-dried to obtain an extract of each plant.

[0072]

[Table 3]

Next, the formulations of the examples of the external preparation for skin according to the present invention are shown below.

[Examples 1 to 4] Cleansing cream (1) Stearic acid 1.60 (% by weight) (2) Palmitic acid 1.30 (3) Tri (beef tallow fatty acid / mink oil fatty acid / cod liver oil 3. 80 fatty acid) glyceryl (4) squalane 40.00 (5) deodorized refined beeswax 6.00 (6) jojoba oil 4.30 (7) cetanol 1.20 (8) tocopherol acetate 0.10 (9) glyceryl monostearate Ester 0.80 (10) 1,3-butylene glycol 3.00 (11) Glycerin 8.00 (12) L-arginine 0.30 (13) Methyl paraoxybenzoate 0.10 (14) Plants shown in Table 4 Extraction mixture 0.05 (15) Plant extract shown in Table 4 Amount shown in Table 4 (16) Purified water Amount to make the total amount 100.00 (17) Perfume 0.10 Production method: (1) to (9) Mix oil phase ingredients If melted, heat to 85 ℃
And On the other hand, mix (10) to (16) water phase ingredients and dissolve
Heat to 5 ° C. After gradually adding the oil phase to this aqueous phase component to pre-emulsify, homogenize with a homomixer,
Cool and add (17) at 40 ° C. and mix.

[0075]

[Table 4]

[Examples 5 to 8] Cleansing lotion (1) Ethanol 15.00 (% by weight) (2) Polyoxyethylene (20 E.O.) sorbitan 1.50 Monolauric acid ester (3) Polyoxyethylene Polyoxypropylene 1.50 Block polymer (4) Isostearic acid 0.05 (5) Tri (capryl-capric acid) glyceryl 0.05 (6) Squalane 0.10 (7) Jojoba oil 0.10 (8) Deodorization purification Beeswax 0.01 (9) Methyl paraoxybenzoate 0.10 (10) Perfume 0.05 (11) Glycerin 5.00 (12) 1,3-Butylene glycol 10.00 (13) Sodium citrate 0.01 ( 14) Plant extract mixture shown in Table 5 0.01 (15) Plant extract shown in Table 5 Amount shown in Table 5 (16) Purified water 100.00 : (1) a mixture of (2) to (10), dissolved to obtain an ethanol phase. On the other hand, (11) to (16) are mixed and dissolved to form an aqueous phase, and the ethanol phase is added to the aqueous phase to solubilize it.

[0077]

[Table 5]

[Examples 9 to 12] Cleansing foam (1) Stearic acid 10.00 (% by weight) (2) Palmitic acid 10.00 (3) Myristic acid 12.00 (4) Lauric acid 4.00 (5) Glyceryl triundecanoate 0.30 (6) Squalane 1.00 (7) Deodorized refined beeswax 0.20 (8) Jojoba oil 2.00 (9) Polyethylene glycol 10.00 (average molecular weight 1,500) ( 10) Glycerin 15.00 (11) Potassium hydroxide 6.00 (12) Methyl paraoxybenzoate 0.10 (13) Purified water Amount to make the total amount 100.00 (14) Glyceryl monostearate 2.00 ester ( 15) Polyoxyethylene (20 E.O.) sorbitan 2.00 Monostearate (16) Plant extraction mixture shown in Table 6 0.02 (17) Table 6 Plant extract shown in Table 6. Amount (18) Perfume 0.10 shown in Table 6 Manufacturing method: (1) to (10) are mixed and dissolved by heating to 70 ° C.
(11) and (12) are dissolved in (13), and the oil phase is added with stirring to sufficiently carry out a neutralization reaction. Then (14), (15)
After adding, the mixture is cooled, and (16) to (18) are mixed and homogenized at 40 ° C. in advance, and then added and mixed.

[0079]

[Table 6]

[Examples 13 to 16] Lotion (1) Ethanol 10.00 (wt%) (2) Polyoxyethylene (20E.O.) sorbitan 1.50 Monolauric acid ester (3) Undecylenic acid 0 .05 (4) Glyceryl triisostearate 0.05 (5) Squalane 0.10 (6) Deodorized refined beeswax 0.02 (7) Jojoba oil 0.10 (8) Methyl paraoxybenzoate 0.10 (9) Perfume 0.05 (10) 1,3-butylene glycol 6.00 (11) Glycerin 4.00 (12) Plant extract mixture shown in Table 7 0.01 (13) Plant extract shown in Table 7 Amount shown in Table 7 (14) Purified water Amount to make the total amount 100.00 Manufacturing method: (2) to (9) are mixed and dissolved in (1) to obtain an ethanol phase. On the other hand, (10) to (14) are uniformly mixed and dissolved to form an aqueous phase. The ethanol phase is added to the aqueous phase and mixed uniformly.

[0081]

[Table 7]

[Examples 17 to 20] Emulsion (1) Stearic acid 2.70 (wt%) (2) Tricoconut oil fatty acid glyceryl 1.50 (3) Squalane 3.00 (4) Deodorized refined beeswax 2. 00 (5) Jojoba oil 2.00 (6) Cetanol 1.00 (7) Glycerin 5.00 (8) L-arginine 0.40 (9) N-stearoyl monosodium glutamate 0.30 (10) Purified water Total amount (11) Ethanol 4.00 (12) Methyl paraoxybenzoate 0.10 (13) Perfume 0.10 (14) Plant extraction mixture shown in Table 8 0.04 (15) In Table 8 Plant extract shown Amount shown in Table 8 Manufacturing method: The oil phase components of (1) to (6) are mixed, heated and dissolved to give 75
℃. On the other hand, the water phase components (7) to (10) are mixed and dissolved to reach 75 ° C. The above oil phase is added to this, and the mixture is emulsified with a homomixer and then cooled, and (11) to (15) are added and mixed at 40 ° C.

[0083]

[Table 8]

[Examples 21 to 24] Cream (1) Stearic acid 3.00 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 7.00 (3) Squalane 10.00 (4) Deodorization purification Beeswax 2.00 (5) Jojoba oil 3.00 (6) Cetanol 5.00 (7) Propylene glycol monostearic acid 3.00 Ester (8) Polyoxyethylene (20E.O.) cetyl ether 3.00 (9) ) D-δ-tocopherol 0.15 (10) 1,3-butylene glycol 5.00 (11) glycerin 5.00 (12) potassium hydroxide 0.20 (13) plant extract mixture shown in Table 9 0.02 (14) Plant extract shown in Table 9 Amount shown in Table 9 (15) Purified water Amount to make the total amount 100.00 (16) Perfume 0.10 Production method: Mix the oil phase components of (1) to (9) , Melted by heating, 70 ℃
And On the other hand, after mixing and dissolving the water phase components (10) to (15), the mixture is heated to 70 ° C., and the oil phase is added thereto to emulsify. After cooling, (16) is added and mixed at 40 ° C.

[0085]

[Table 9]

[Examples 25 to 28] Packing agent (1) Polyvinyl acetate emulsion 15.00 (% by weight) (2) Polyvinyl alcohol 10.00 (3) Sorbitol 5.00 (4) Polyethylene glycol (average) Molecular weight 400) 5.00 (5) Plant extract mixture shown in Table 10 0.02 (6) Plant extract shown in Table 10 Amount shown in Table 10 (7) Purified water Amount with total amount of 100.00 (8) Titanium oxide 5.00 (9) Talc 10.00 (10) Ethanol 8.00 (11) Isopalmitic acid 0.20 (12) Glyceryl tristearate 0.25 (13) Squalane 2.00 (14) Deodorization purification Beeswax 0.05 (15) Jojoba oil 2.00 (16) Polyoxyethylene (20E.O.) sorbitan 1.00 Monostearate (17) Paraoxybenzoic acid Le 0.10 (18) Perfume 0.10 Preparation: (7) (3) after addition to (6), by dispersing (8), (9) 7
Heat to 0 ° C., then add (1) and (2) to dissolve. (Ten)
(11) to (18) are added to and dissolved in, and added to the aqueous phase, mixed, and cooled.

[0087]

[Table 10]

Example 29 Lotion (1) Ethanol 20.000 (wt%) (2) Polyoxyethylene (60 E.O.) hydrogenated castor oil 1.500 (3) Methyl paraoxybenzoate 0.100 ( 4) 12-hydroxystearic acid 0.020 (5) tri (capryl / caprin / isostearin / 0.500 adipic acid) glyceryl (6) squalane 0.200 (7) deodorized refined beeswax 0.005 (8) jojoba oil 0 200 (9) 1,3-butylene glycol 10.000 (10) Plant extraction mixture 4 0.020 (11) Roman chamomile extract 0.001 (12) Fennel extract 0.001 (13) Hop extract 0 0.001 (14) Achillea millefolium extract 0.001 (15) Melissa extract 0.001 (16) Mistletoe extract 0.001 (17) Horse mackerel extract Outbreak 0.002 (18) Parsley extract 0.002 (19) Fuyudaiju extract 0.010 (20) Birch extract 0.010 (21) Beech extract 0.010 (22) Purified water 67.415 Manufacturing method: (1) to (8) are mixed and dissolved, and then (9) to (21) are sequentially added and dissolved, and then added to (22) and uniformly mixed and dissolved.

Example 30 Water-in-oil emulsion (1) Microcrystalline wax 1.000 (% by weight) (2) Behenic acid 2.000 (3) Trilanolin fatty acid glyceryl 2.000 (4) Squalane 25.000 (5) Deodorized refined beeswax 2.000 (6) Jojoba oil 5.000 (7) Sorbitan sesquioleate 4.000 (8) Polyoxyethylene (20E.O.) sorbitan 1.000 Monooleate (9) ) Propylene glycol 7.000 (10) Methyl paraoxybenzoate 0.100 (11) Plant extraction mixture 2 0.050 (12) Hamamelis extract 0.020 (13) Parsley extract 0.005 (14) Fuyudaidai extract Product 0.005 (15) Birch extract 0.005 (16) Beech extract 0.005 (17) Purified water 50.8 0 Preparation: (1) dissolved by heating a mixture of oil phase component to (8), 70
℃. On the other hand, the water phase components (9) to (17) are mixed, heated and dissolved to 70 ° C. This aqueous phase is added to the oil phase, emulsified with a homogenizer, and then cooled.

[Example 31] Oil-in-water cream (1) Stearic acid 1.70 (% by weight) (2) Palmitic acid 1.30 (3) Behenic acid 0.20 (4) Tri (beef tallow fatty acid / mink) Oil fatty acid / Cod liver oil 3.00 Fatty acid) glyceryl (5) Tricoconut oil fatty acid glyceryl 1.80 (6) Squalane 5.00 (7) Deodorized refined beeswax 3.00 (8) Jojoba oil 2.00 (9) Monostearin Glyceryl acidate 0.70 (10) Cetyl isooctanoate 5.00 (11) N-stearoyl monosodium glutamate 0.30 (12) Glycerin 10.00 (13) L-arginine 0.30 (14) Methyl paraoxybenzoate 0 .10 (15) Purified water 65.40 (16) Plant extraction mixture 4 0.10 (17) Chamomile extract 0.01 (18) Achillea millefolium extract 0 .01 (19) coltsfoot extract 0.01 (20) biloba oyster extract 0.01 (21) Hypericum extract 0.01 (22) Ginkgo biloba extract 0.05 Process: (1) to (10) oil Mix phase ingredients and heat to dissolve
Set to 5 ° C. On the other hand, the aqueous phase components (11) to (15) are mixed, dissolved and heated to 75 ° C. Then, the oil phase component is added to the aqueous phase component to preliminarily emulsify the mixture and then homogenize with a homomixer. After cooling, (16) to (22) are mixed in advance at 40 ° C.,
Homogenize and add and mix.

The above-mentioned examples of the present invention were subjected to a usage test by a female panelist exhibiting remarkable skin roughening symptoms.
In the use test, 20 panelists per group were used, and each group was blinded to each of Example 15, Example 17, Example 31, and Comparative Example 15, Comparative Example 17, and Comparative Example 31 described later. Example 28 and Comparative Example 28 described later were used twice a day for 1 month at a frequency of 3 times a week for 1 month. Comparative Example 15, Comparative Example 17, Comparative Example 28 and Comparative Example 31 were prepared by blending a plant extract and an oily component as shown in Table 11 in Example 15, Example 17, Example 28 and Example 31, and purifying them. The total amount was adjusted to 100% by weight with water. Further, among the skin external preparation groups of Example group 1, Example group 2, Comparative example group 1 and Comparative example group 2 of the present invention shown in Table 12, cleansing foam, lotion, emulsion and cream are used in the morning, and The skin was maintained for 1 month using cleansing cream, cleansing lotion, cleansing foam, lotion, emulsion and cream. further,
During the 1-month use period, the pack was used twice a week. In addition, Comparative Example Group 1 and Comparative Example Group 2 show all plant extracts contained in each of the skin external preparations constituting Example Group 1 and Example Group 2 as shown in Table 1.
It was prepared in place of the plant extract shown in 2.

[0092]

[Table 11]

[0093]

[Table 12]

With respect to the panelists of each group, the skin condition was observed and the water content of the stratum corneum was measured before and after the start of the use test, and the familiarity of the skin was evaluated for each sample.
In addition, during the use test period, an interview survey was conducted to find out if there was any feeling of skin irritation or abnormalities such as erythema or rash when the sample was used. The skin condition was evaluated and scored according to the evaluation criteria shown in Table 13, and the average value of 20 persons was calculated and shown. The stratum corneum water content was indicated by the measured value of skin surface conductance (μMuo). Regarding the familiarity with the skin, the feeling of skin irritation, and the presence or absence of skin abnormality, the results were scored according to the evaluation criteria shown in Table 14, and the average value of 20 persons was calculated. The results are summarized in Table 15.

[0095]

[Table 13]

[0096]

[Table 14]

[0097]

[Table 15]

In Table 15, in the use groups of Example 15, Example 17, Example 28 and Example 31 of the present invention, the skin condition was improved to almost good condition, and the stratum corneum water content was also significantly increased. It is recognized that Further, in the groups using Example group 1 and Example group 2, more remarkable improvement in skin condition and increase in stratum corneum water content were observed. On the other hand, Comparative Example 15 containing only the plant extraction mixture 2,
Comparative Example 17 containing plant extraction mixture 1 and liquid paraffin and cetanol as oily components, containing squalane and jojoba oil as oily components, containing plant extracts such as fennel but not containing plant extraction mixture 3 In each of the use groups of Example 28 and Comparative Example 31 containing only an oily component consisting of fatty acid, fatty acid triglyceride, squalane, beeswax and jojoba oil, the skin condition was improved but the degree thereof was not sufficient. The amount of increase in the amount was also significantly smaller than that in the corresponding group using the Example. Even in the group using Comparative Example Group 1 and Comparative Example Group 2, which consisted of an external skin preparation containing only one plant extract and an oily component consisting of fatty acid, fatty acid triglyceride, squalane, beeswax and jojoba oil, Improvement of skin condition and increase of stratum corneum water content were insufficient.

Further, the examples and example groups of the present invention were evaluated as having good compatibility with the skin, and compared with the corresponding comparative examples and comparative example groups, respectively. The evaluation was also significantly higher. Further, regarding each sample used in the use test this time, no problematic skin irritation feeling or skin abnormality was observed as shown in Table 15, but in Examples and Example groups of the present invention,
A reduction tendency of skin irritation was observed as compared with the corresponding Comparative Examples and Comparative Example groups.

For each example of the present invention, 25 ° C.
When stored for 6 months, no change in state such as coloring, odor, aggregation, precipitation or deposition of contents components, and phase separation was observed.

[0101]

As described above in detail, according to the present invention, a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect are obtained.
Moreover, it was possible to obtain an external preparation for the skin, which had good compatibility with the skin and which was excellent in formulation stability and safety.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI A61K 7/50 A61K 7/50 (56) References JP-A-6-157153 (JP, A) JP-A-9-221409 (JP , A) JP 2000-119156 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (2)

(57) [Claims] 1. A skin external preparation containing a combination of an extract mixture of a specific plant and one or more extracts selected from a specific plant group, comprising the following (A) and (B):
(C) and (D), (E) and (F), and a plant extract consisting of a combination of any one of (G) and (H), and 1 of fatty acids having 10 to 22 carbon atoms. Seeds or two or more,
A skin external preparation containing one or more kinds of fatty acid triglycerides, squalane, beeswax and jojoba oil: (A) Chamomile ( Matricaria chamomilla L.), fennel ( foeniculum vulgare Miller), hop ( Humulus )
lupulus L.), yarrow ( Achillea mill)
efolium L.), Melissa ( Melissa officinalis L.) and mistletoe ( Viscum coloratum Nakai var. lutescens)
Miyabe et Kudo or Viscum album L. var. Lutescens M
extraction mixture of akino); (B) horse chestnut (Aesculus turbinata Blume), horse chestnut (Aesculus hippocastanum L.), carrot (Daucus carota L.), rosemary (Rosmarinus off
icinalis L.), Calendula officinal
is L.), Calendula arvensis L., Cornflower ( Centaurea cyanus L.), Horsetail ( Equisetum )
arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyp
tus spp.), plants belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis )
sativus L.), coltsfoot ( Tussilago farfara )
L.), Birodo aoi ( Althaea officinalis L.), plants belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of
ficinalis var. tenuior ), Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.), Thymus vulgaris
L.), Tormentilla ( Potentilla tormentilla ), Fern ( Glycyrrhiza uralensis Fisher, Glycyrrhiza)
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. et Herd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum cris
pum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) 1 or 2 selected from the plant group consisting of
(C) Extraction mixture of fennel ( Foeniculum vulgare Miller), horse chestnut ( Aesculus turbinata Blume) and / or horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.); (D) chamomile (C) Matricaria chamomilla L.), hops ( Humulus lupulus L.), yarrow ( Achi )
llea millefolium L.), Melissa officinal
is L.), mistletoe ( Viscum coloratum Nakai var. lut
escens Miyabe et Kudo or Viscum album L. var. lute
scens Makino), Mannenrou ( Rosmarinus officinal )
is L.), Calendula officinalis
L.), Calendula arvensis L., Cornflower ( Centaurea cyanus L.), Horsetail ( Equisetum a )
rvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptu)
s spp.), plants belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis s )
ativus L.), coltsfoot ( Tussilago farfara )
L.), Birodo aoi ( Althaea officinalis L.), plants belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of
ficinalis var. tenuior ), Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.), Thymus vulgaris
L.), Tormentilla ( Potentilla tormentilla ), Fern ( Glycyrrhiza uralensis Fisher, Glycyrrhiza)
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. etHerd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum cris
pum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) 1 or 2 selected from the plant group consisting of
(E) Chamomile ( Matricaria chamomilla L.), yarrow ( Achillea millefolium L.), one or two of the plants belonging to the genus Hypericum ( Hypericum spp.)
Species and above, coltsfoot ( Tussilago farfara L.), velour's mallow ( Althaea officinalis L.), salvia ( Sa
lvia officinalis L.) and / or its variants ( Salvia of
Ficinalis var. tenuior ) extraction mixture; (F) Fennel ( Foeniculum vulgare Miller), hops ( Humulus lupulus L.), Melissa offi
cinalis L.), mistletoe ( Viscum coloratum Nakai va
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino), Aesculus turbinat
a Blume), Horse chestnut ( Aesculus hippocastanu
m L.), carrots ( Daucus carota L.), mannose wax ( Rosmarinus officinalis L.), Calendula officinalis ( Cal )
endula officinalis L.), Calendula (Calendula arv
ensis L.), cornflower ( Centaurea cyanus L.),
Horsetail ( Equisetum arvense L.), plant belonging to the genus Eucalyptus ( Eucalyptus spp.), Plant belonging to the genus Aloe ( Aloe spp.), Quince ( Cydonia oblonga Mill.),
Cucumber (Cucumis sativus L.), Hamamelis (Hamame
lis virginiana L.), hawthorn ( Hamemelis japonica )
Sieb. Et Zucc.), Thymus vulgari
s L.), Tormentilla ( Potentilla tormentilla ),
Glycyrrhiza uralensis Fisher, Glycyrrhiz
a glabra L. and its variants, Glycyrrhiza echinata L.,
Glycyrrhiza glandulifera Reg. Et Herd.), Plants belonging to the genus Lily ( Lilium spp.), Parsley ( Petroselinum cr )
ispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Be
tula spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.) Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemis
nobilis L.) 1, two or more extracts selected from the group of plants consisting of;. (G) Salvia (Salvia officinalis L.) and / or its variants (Salvia officinalis var tenuior), Hamamelis (Hamamelis virginiana L. ), Tati thyme (Thymus vulgaris L.), Torumentira (Potentil
la tormentilla ), Mannenrou ( Rosmarinus officin
alis L.) extraction mixture; (H) chamomile ( Matricaria chamomilla L.), fennel ( foeniculum vulgare Miller), hops ( Humulus )
lupulus L.), yarrow ( Achillea mill)
efolium L.), Melissa officinalis L.),
Mistletoe ( Viscum coloratum Nakai var. Lutescens Mi
yabe et Kudo or Viscum album L. var. lutescens Mak
ino), Horse chestnut ( Aesculus turbinata Blume), Horse chestnut ( Aesculus hippocastanum L.), Carrot ( Daucus carota L.), Calendula ( Calendula )
officinalis L.), Calendula arvensis
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), Plants belonging to the genus Aloe ( Aloe)
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago )
farfara L.), Below Aoi ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.
p.), witch hazel (Hamamelis japonica Sieb. et Zuc
c.), licorice ( Glycyrrhiza uralensis Fisher, Glyc
yrrhiza glabra L. and its variants, Glycyrrhiza echinat
a L., Glycyrrhiza glandulifera Reg. et Herd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroseli
num crispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo
biloba L.), Wolverine ( Hedera tobleri Nakai), Western Wolverine ( Hedera helix L.) and Roman chamomile ( A )
nthemis nobilis L.) one or more kinds of extracts selected from the group of plants. 2. A skin care method, which comprises using two or more kinds selected from the external preparations for skin according to claim 1 in combination.