KR20090059445A

KR20090059445A - Composition for preventing alopecia or growing hair containing the cation/anion mixed surfactant comprising the extracts of medical herbs

Info

Publication number: KR20090059445A
Application number: KR1020070126309A
Authority: KR
Inventors: 민선호; 민지현
Original assignee: 주식회사 솔레오
Priority date: 2007-12-06
Filing date: 2007-12-06
Publication date: 2009-06-11

Abstract

A composition for preventing hair loss and promoting hair growth is provided to promote the proliferation of follicular cell and transition to the hair growth cycle without scalp irritation. A composition for preventing hair loss and promoting hair growth comprises 0.1-0.2 weight% of cationic/anionic surfactant vesicle having herb extract. The herb extract is selected from 0.1-20 weight% of sophorae Radix, angelicae gigantis Radix, cnidii Rhizoma, glycyrrhizae radix, and wild chamomile. The anionic/cationic surfactant vesicle of double structure contains 0.45-0.90 molar fraction of cationic surfactant and 0.55-0.10 molar fraction of anionic surfactant. The cationic surfactant is selected from cetyltrimethyl ammonium chloride and octadecyltrimethyl ammonium chloride.

Description

Composition for preventing alopecia or growing hair containing the cation / anion mixed surfactant comprising the extracts of medical herbs}

The present invention relates to a hair composition for preventing hair loss and hair growth, and more particularly, to a bilayer structure comprising a Chinese herbal extract having a hair follicle cell (hair papilla cell) growth and anti-male hormone action and a normalizing function of the hair cycle. By containing a cationic / anionic surfactant mixed vesicle having cationic properties, it promotes adsorption to hair and scalp, and prevents hair loss produced to enhance the effect of the herbal extract itself without causing scalp irritation. It relates to a composition for hair for hair growth.

In the modern society that emphasizes beauty, various studies are being actively conducted around the world to treat and promote hair growth of men or women suffering from severe mental pain due to genetic or environmental hair loss.

Human hair is about 100,000 to 150,000, each hair will grow and degenerate through different cycles. Hair is a growing period (Anagen), a degenerative period (Catagen) where metabolic processes slow down while maintaining the shape of the hair, and hair papilla atrophy, hair follicles atrophy gradually, hair roots are pushed upwards, and the hair follicles become smaller (Telogen) The three-step cycle of) is repeated, and the hair cycle and lifespan may vary according to various conditions such as nutrition, medical history, heredity, constitution, hormone secretion or aging.

Among the existing anti-hair loss treatments, external minoxidil approved by the US FDA, in addition to its vasodilating function as its unique potassium channel opener, induces the growth phase in the resting hair cycle and maintains the induced growth hair cycle. Activity has been reported (British Journal of Dermatology. 2004; 150: 186-194).

In addition, an oral administration drug, Finasteride (Propecia; MSD), which inhibits the action of 5 alpha-reductase and inhibits the production of the active male hormone dihydrotestosterone, is marketed as a hair regrowth with the approval of the US FDA. However, there is a limit to use as the occurrence of expensive and side effects are reported. Thus, there has been a continuing need for drugs that are free of hair growth and side effects compared to the two major drugs previously developed.

As such, research on hair loss preventing agents and hair loss agents has been intensified, and various products have been developed. However, excellent efficacy and safe hair loss preventing agents are insufficient. Related products currently developed include minoxidil in the West, Propecia hair regrowth and hair growth agents containing herbal extracts in Japan, but it is still too early to prevent hair loss and solve hair growth.

In particular, hair loss preventives and hair repellents containing herbal extracts have fewer side effects than those containing conventional medicines, but in order to achieve their effects, they must be used in very large amounts, so it is difficult to commercialize and washes hair products such as shampoo or hair conditioner. In this case, there is a disadvantage that it is difficult to achieve the effect, there is an urgent need for a method that can enhance the effect of herbal extracts.

Therefore, the present inventors first of all agree on the basis of oriental medicine theory (Ho Joon: Dong-Ho Bo-Gam, Seoul, Daesung Cultural History, 1992) and the Famine Efficacy Efficacy Discharge Book (Jang Jun-Jung: The Distress Efficacy Efficacy Discharge Book, Beijing, Chinese Medicine Publisher, 1994), Shinsengbang 999 (Yangsoon Jang, Icer: Shinsengbang 999, Beijing, Chinese Medicine Publishers, 1999), Chinese Medicines for External Use of Skin Diseases (Song Zhao Wu: Chinese Medicines for External Use of Skin Diseases, Beijing, People's Hygiene Publishers, 2000) : Chinese herbal medicine classified by the symptom such as malnutrition, aging, hair loss and gray hair of hair loss based on the 288 prescriptions related to hair diseases listed in Chinese Beauty Treatment Competition, Beijing, Chinese Medicine Publishers, 2001) Studies on the effects of prevention and hair growth showed that ginseng, Angelica, cheonggung, persimmon among herbal extracts with the function of promoting the growth of hair follicle cells (hair papilla cells), anti-male hormone action and normalizing hair cycle The present invention has been found to contain 5 or more of the extracts of wild, wild chrysanthemum, and uiyiin to promote hair follicle cell proliferation, inhibit the action of 5 alpha-reductase, and promote the transition from the resting hair cycle to the growing hair cycle. It was.

In addition, the present inventors have tried to find a delivery method that can maximize the effect while using the herbal extract in a hair product in a relatively small amount, as a result, the cationic / anionic surfactant mixed vesicle having a bilayer structure of cationic The present invention was completed by discovering that the composition for hair containing the same by encapsulating it enhances hair loss prevention and hair growth effects without scalp irritation.

Therefore, it is an object of the present invention to provide a composition for hair for hair loss prevention and hair growth.

In order to achieve the above object, in the present invention, hair loss containing a cationic / anionic surfactant mixed vesicle having a bilayer structure comprising five or more Chinese herbal extracts of red ginseng, Angelica, cheonggung, licorice, wild chrysanthemum and Euiin extracts. Provided are compositions for hair for prevention and hair growth.

The composition for hair according to the present invention comprises five or more of the extracts of red ginseng, Angelica, cheonsugung, licorice, wild chrysanthemum and Euiin according to the present invention comprising a cationic surfactant having a mole fraction of 0.45 to 0.90 and an anionic surfactant having a mole fraction of 0.55 to 0.10. By containing in a bilayer-type cationic / anionic surfactant mixed vesicle, relatively small amount of herbal extracts are delivered without irritation to scalp to promote hair follicle proliferation and transition from resting hair cycle to growing hair cycle. Indicated.

Hereinafter, the present invention will be described in more detail.

Hair generally has an isoionic point and isoelelctric point. In particular, the isoelectric point refers to the pH when it does not move in the electric field in relation to the acid-base characteristics of the hair surface. Therefore, this isoelectric point has an important effect when adsorbing active ingredients to hair. Human hair is generally known to have an isoelectric point between pH 3.5 and pH 4.0. And since most of the cosmetic composition for hair and scalp is at least pH 5.0 or more when applied to the hair and scalp the hair becomes an environment above the isoelectric point to show the anion. Therefore, more negatively adsorbed compositions are adsorbed on such anionic hair. In addition, membranes of biological tissues such as hair and scalp have a double layer structure. Therefore, to apply the active ingredient through the membranes of biological tissues such as hair and scalp, the active ingredient is better delivered by affinity and is more likely to penetrate hair and scalp when it is stabilized by a bilayer structure similar to the membrane of biological tissues.

Based on this theory, in the present invention, a relatively small amount of herbal extract is well adsorbed on the surface of the hair having anions so as to promote hair growth prevention and hair growth effects without irritation, while maintaining the membrane of biological tissues such as hair and scalp. It has been developed a hair composition that can be easily delivered to and easily penetrated.

Unless stated otherwise, all percentages and ratios set forth herein are based on weight.

Red ginseng has been studied in herbs for a long time about its efficacy. Ginseng is a perennial herb that is about 1m high in legumes, and its leaf shape is similar to a painting tree (miscarpment), nicknamed worms, lumps, and wild beasts. It is called ginseng because it has the same effect as ginseng. Ginseng contains alkaloids throughout the plant, and the components of alkaloids include matrin (sofocarpidine), oxymatrine, sophoranol, anagiline, methylcytizin, babtiplin, sopocarpine and allomatrine. There is a sugar of%. Flavonol compounds, such as isoanhydroicaridine and noanhydroicaridine, are also isolated from the roots, glucoluteolin in flowers, camphorol-3-sulforoside and henisteine in flowers, and henistein-4- in fruits. Rhamnosyl glycosides were identified. Ginseng is used as a placebo medicine, diuretic, antipyretic, analgesic and insecticide in oriental medicine, and it is also used for the treatment of jaundice, difficulty urinating, scabies, eczema and dry ringworm. It is also used to treat hemorrhoids and bleeding. It is also used for bronchitis and pulmonary tuberculosis as a palliative and phlegm. Citgin is seen as the main cause, and the plaster made from root is also used for trichomoniasis, eczema and neurodermatitis.

Angelica is a perennial herbaceous herbaceous herb, and there are two kinds of perennial herb, seungdang gui, and sesame. One ear contains vergatten, isopypineline, essential oils, nicotinic acid, and vitamin B _{12. The} essential components of essential oils are n-butylidenephthalate and ligustilite, which are intrinsic odors. Angelica gigas (seunggeumcho) has coumarin components such as decursin, decursinol, nodakenerine, umbeliferon, nodakenin, xanthotoxin, isoprimpineline, ostol and umbellininine at the root. Angelica helps metabolism by activating protein synthesis, increasing the absorption of uterine tissue and increasing glucose absorption, and regenerating bone marrow to help hematopoiesis. Root essential oil solution has analgesic and anti-inflammatory effect on arthritis.

Cheonggung is a perennial herb of the Araaceae family, and is native to China. There are coumarins and mannitol throughout the plant, and essential oils (knidilide, neoctilide, liqueustilide, cheongung acid, butylphthalide and cheongung acid ester) in the roots. It has been used as a warming pill, blood donor, tonic and sedative since ancient times, and is often used together with donkey in anemia, cold, dysmenorrhea and gynecological diseases.

Licorice (Glycyrrhizae radix) contains a number of flavonoids, mainly glycyrrhizin, liqueurigenin and liqueurine, and has been used in many prescriptions for many years because of its detoxification, sedation, anti-inflammatory and anti-allergic effects.

Coicis semen has the efficacy of dry swelling, swallow branch and blue heat drainage, mainly starch, fat oil, nose It contains Coixol, Sterol, amino acids, vitamin B1 and Coixenolide. The annual planting of rice plants is herbaceous and is also known as Yulmu, Hayeom, Okdam, Gishil and Gongmi. When water is decomposed in Uiin, it is decomposed into various amino acids. The most leucine is leucine, and the acetone extract of seeds contains coixenolide, and the root is coicsol. Pharmacological action is anti-inflammatory, lowers the amount of hypercholesterol and has a calming and analgesic effect, so it is also used as an injection for neuralgia or arthralgia. It is also useful for indigestion, arthralgia and muscle spasms. It is effective for the recovery of fatigue, blemishes, and freckles. It is effective for removing blemishes on the face, whitening effect, and expanding and contracting peripheral nerves. Neuralgia is also effective.

Wild chrysanthemums include essential oils (such as borneo, bornyl acetate diecampa, tetracozan and hexacozan), acecetin compounds, glucoside (acacetin-7-rhamnoglucoside), adenine, choline and carbohydrates (fructose, glucose, sucrose arabinose, galac) Tods and rhamnose). In addition, it contains vitamin A and vitamin B1. It has been used in the treatment of carbuncle, sperm, purpose, bare pot, peony spear (impetigo) and eczema because it has the efficacy of clearing, picnic, swelling and detoxification.

Red ginseng, Angelica and cheongung extract used in the present invention can be prepared by heating and extracting with alcohol, filtration and concentrated under reduced pressure by adding water and ethyl acetate.

In addition, licorice, wild chrysanthemum and Euiyichuchu extract used in the present invention can be prepared by adding a butylene glycol after removing the odor with activated charcoal extracted by heating with ethanol.

The composition for hair according to the present invention uses the extracts of red ginseng, Angelica, cheonsugung, licorice, wild chrysanthemum, and Euiin in 0.1% to 20% of the total weight of the composition, preferably 1.0% to 10%. When the content of the herbal extract is 0.1% or less, hair loss prevention and hair growth effects are less, and when 20% or more, hair loss prevention and hair growth effects are excellent, manufacturing cost increases and there is room for skin irritation.

Cationic / anionic surfactant mixed vesicles with cationicity of double layer structure are cationic so that adsorption on the anionic hair surface and scalp is better, and after adsorption, membranes of biological tissues such as hair surface and scalp and It has a similar bilayer structure, and its affinity allows better penetration of Chinese herbal extracts into hair and scalp. The herbal extract thus infiltrated is diffused from the hair and the scalp and is better delivered to the dermal papilla cells to promote hair loss prevention and hair growth effects.

This cationic / anionic surfactant mixed vesicle having a bilayer structure is a mixed system consisting of a cationic surfactant of a single alkyl group having 16 to 18 carbon atoms and an anionic surfactant of a single alkyl group having 12 carbon atoms. And form a bilayer vesicle that is stable and fully cationic. In addition, for the cationic / anionic surfactant mixed vesicle to be cationic, the mole fraction of the cationic surfactant of a single alkyl group of 16 to 18 carbon atoms must be between 0.45 and 0.90.

As for the cationic / anionic surfactant mixed vesicle having a bilayer structure of cationic used in the present invention, cationic surfactants have a mole fraction of 0.45 to 0.90, and anionic surfactants have a mole fraction of 0.55 to 0.10.

Cationyl trimethylammonium chloride or octadecyltrimethylammonium chloride is suitable for the cationic surfactant used in the present invention, and the anionic surfactant is preferably, but not limited to, ammonium lauryl sulphate or sodicurlauryl sulfate. .

The hair composition according to the present invention contains the above cationic / anionic surfactant mixed vesicles at 0.1% to 0.2% based on the total weight of the composition. If the content of the vesicle is 0.1% or less, it is difficult to collect the herbal extract as an active ingredient, and if it is 0.2% or more, it is difficult to use because it has a very low solubility in water and a strong hydrophobic complex due to strong attraction between counter ions. .

Hair composition for hair loss prevention and hair growth according to the present invention is not particularly limited in formulating, but may be formulated with hair tonic, scalp treatment, hair shampoo, hair conditioner and hair cream.

Hereinafter, the structure and the effect of the present invention will be described in more detail with reference to Examples and Test Examples. However, these examples are for illustrating the present invention, and the present invention is not limited only to these examples.

Reference Example 1 Preparation of Red Ginseng, Angelica, and Cheongung Extract

1.5 kg of red ginseng was added to the extractor and 3 kg of 95% synthetic alcohol was added. Heat extraction was performed at reflux temperature for 6 hours. After cooling to room temperature, the product was filtered under reduced pressure with a filter paper. The filtrate was concentrated under reduced pressure to remove the synthetic alcohol, and then water and ethyl acetate each of 5 times the amount of the concentrate were added to the concentrate, followed by stirring and layer separation. The water layer was discarded and the ethyl acetate layer was concentrated under reduced pressure to obtain an extract of about 120 g.

The same method as above was used to obtain the extract of Angelica und Angelis.

Preparation Example 2 Preparation of Licorice, Wild Chrysanthemum and Eui-in Extract

After removing fine dust and the like using ultrapure purified water, foreign matters were removed using ultrapure purified water using 250 mesh. After drying the licorice for 24 hours at 50 ℃, 50 kg of dried licorice was mixed with 250 kg of 50% ethanol (EtOH) and extracted by heating at 60 ℃ 3 hours to 5 hours. Foreign matters were removed by using a 250 mesh and centrifugation, filtered through a 0.5 ㎛ filter paper and treated with activated carbon to remove the color and smell of the extract. After filtering through 3, 1 and 0.5 μm filter paper over 3 times, butylene glycol solvent was added to obtain a licorice extract.

Wild chrysanthemum and Euiyiin extract were also obtained through the same process as above.

[Examples 1-4 and Comparative Examples 1-3]

Each of the components shown in Table 1 were mixed to prepare Examples 1 to 4 and Comparative Examples 1 to 3 (unit: wt%).

ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Red ginseng extract 0.5 - 0.5 0.5 0.5 0.5 0.5 Angelica Extract - 0.5 0.5 0.5 0.5 0.5 0.5 Cheonung Extract 0.5 0.5 0.5 0.5 0.5 0.5 - Licorice extract - 0.5 0.5 0.5 0.5 - 0.5 Wild chrysanthemum extract - 0.5 0.5 0.5 - 0.5 0.5 Euiin Extract - 0.5 - - 0.5 0.5 0.5 Octadecyltrimethylammonium chloride - - 0.06 0.09 0.12 0.18 Ammonium Lauryl Sulfate - - 0.04 0.01 0.08 0.02 Purified water balance balance balance balance balance balance balance

Test Example 1 Stability Test

UV spectroscopy was used to determine the stability of the cationic / anionic surfactant mixed vesicle having a bilayer structure containing the herbal extract. Examples 1 and 3 contained herbal extracts in mixed cation / anionic surfactant vesicles with different molar fractions of octadecyltrimethylammonium chloride, which are cationic surfactants of a single alkyl group, of 0.55 but 0.1% and 0.2%, respectively. In Examples 2 and 4, the molar fractions of octadecyltrimethylammonium chloride, which are cationic surfactants of a single alkyl group, are all 0.88, but are used in the mixed cation / anionic surfactant mixed vesicles at 0.1% and 0.2%, respectively. It contains an extract. Examples 1 to 4 all showed the same excellent stability, in particular, the higher the content of the cation / anionic surfactant mixed vesicles, the stronger the attraction between the counter ions to form a very low solubility in water and strong hydrophobic complexes As shown in FIG. 1, the absorbance measurement results of Example 4 (0.2%) having a high molar fraction of octadecyltrimethylammonium chloride, which is a cationic surfactant of a single alkyl group, and a high content thereof are 0.88. For Example 4, absorbance was measured immediately after preparation, after 4 days, after 7 days, after 10 days, after 30 days, and after 65 days, and the results are shown in FIG. 1.

As shown in the results of FIG. 1, the tendency of absorbance was not significantly changed immediately and after 65 days, but no peak was observed after 65 days at 688 nm after preparation. The fact that the absorbance is almost unchanged indicates that the cationic / anionic surfactant mixed vesicle having the initially formed double layered cationic property has remained stable for at least two months.

Test Example 2 Surface Charge Test

To determine the surface charge of a cationic / anionic surfactant mixed vesicle having a bilayer structure containing a Chinese herbal extract, 0.1% and 0.2% depending on the mole fraction of octadecyltrimethylammonium chloride, a cationic surfactant of a single alkyl group The zeta potential was measured at, and the results are shown in FIG. 2. As shown in the results of FIG. 2, it was found that the surface charge of the cationic / anionic surfactant mixed vesicle exhibited cationicity when the mole fraction of octadecyltrimethylammonium chloride, which is a cationic surfactant of a single alkyl group, was 0.45 or more. In particular, the molar fraction of octadecyltrimethylammonium chloride, which is a cationic surfactant of a single alkyl group, was 0.55, but Examples 1 and 3, each having a different concentration of use as 0.1% and 0.2%, respectively, exhibited surface charges of about 40 to 45 mV. The mole fractions of octadecyltrimethylammonium chloride, which are cationic surfactants of a single alkyl group, are all 0.88 but 0.1 and 0.2%, respectively, and Examples 2 and 4, which have different surface concentrations, exhibit surface charges of about 50 to 60 mV. It can be seen that the sex.

Test Example 3 Hair Loss Prevention Effect Test

Thirty subjects with initial hair loss were tested for anti-hair loss for 12 weeks. After using the compositions of Comparative Examples 1 to 3 and Examples 1 to 4 once a day for 12 weeks, after 12 weeks elapsed after collection of hair loss hair collected again to count the number and the results are shown in Figure 3 It was.

As can be seen from the results of FIG. 3, it was confirmed that the number of falling hairs was significantly reduced compared to Comparative Examples 1 to 3 when treated with the compositions of Examples 1 to 4 according to the present invention.

Test Example 4 Hair Growth Effect Test Through Mouse

7 weeks old mouse (C57BL / 6) was removed, and the back skin was selected to be clean, and eight animals were selected for each substance group, and the composition of Comparative Examples 1 to 3 and Examples 1 to 4 was used each day. 150 μl per mouse group was applied for 21 days.

After 23 days, a photograph of the degree of growth of the mouse hair was taken, and the weight of the newly grown hair was measured, and the results are shown in Table 2 and FIG. 4.

Treatment group Hair weight (mg) Comparative Example 1 65 ± 12 Comparative Example 2 70 ± 10 Comparative Example 3 70 ± 7 Example 1 77 ± 8 Example 2 89 ± 12 Example 3 87 ± 11 Example 4 98 ± 14

In the results of Table 2 and Figure 4, using the octadecyltrimethylammonium chloride / ammonium lauryl sulphate mixed vesicle containing the herbal extract as an active ingredient in the present invention and having a bilayer structure of cationic, the herbal extract alone Higher hair growth could be observed than with.

Hereinafter, based on the results of the above test example, various formulation examples are shown and presented. However, these formulation examples are intended to illustrate the present invention, and it will be apparent to those skilled in the art that the scope of the present invention is not limited to these examples.

Formulation Example 1 Hair Tonic Formulation

ingredient Content (% by weight) ethanol 55 Castor Oil 5 Octadecyltrimethylammonium chloride 0.18 Ammonium Lauryl Sulfate 0.02 Red ginseng extract 0.5 Angelica Extract 0.5 Cheonung Extract - Licorice extract 0.5 Wild chrysanthemum extract 0.5 Euiin Extract 0.5 Spices and Colors A reasonable amount Purified water balance

Formulation Example 2 Hair Lotion Formulation

ingredient Content (% by weight) Cetostearyl alcohol 2.0 Stearyl Triethyl Ammonium Chloride 2.0 Hydroxyethyl cellulose 0.5 Pyrotonolamine 0.1 Octadecyltrimethylammonium chloride 0.18 Ammonium Lauryl Sulfate 0.02 Red ginseng extract 0.5 Angelica Extract 0.5 Cheonung Extract - Licorice extract 0.5 Wild chrysanthemum extract 0.5 Euiin Extract 0.5 Spices and Colors A reasonable amount Purified water balance

<Formulation Example 3> hair nutrient lotion formulation

ingredient Content (% by weight) Beeswax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Liquid paraffin 5.0 Squalane 5.0 Caprylic / Capric Triglycerides 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Triethanolamine 0.2 Octadecyltrimethylammonium chloride 0.18 Ammonium Lauryl Sulfate 0.02 Red ginseng extract 0.5 Angelica Extract 0.5 Cheonung Extract - Licorice extract 0.5 Wild chrysanthemum extract 0.5 Euiin Extract 0.5 antiseptic A reasonable amount Spices and Colors A reasonable amount Purified water balance

<Formulation Example 4> Shampoo Formulation

ingredient Content (% by weight) Sodium lauryl sulphate 10.0 Polyoxyethylene lauryl ammonium sulfate 5.0 Cocoamidopropylbetaine 5.0 Ethylene Glycol Distearate 1.0 Octadecyltrimethylammonium chloride 0.18 Ammonium Lauryl Sulfate 0.02 Red ginseng extract 0.5 Angelica Extract 0.5 Cheonung Extract - Licorice extract 0.5 Wild chrysanthemum extract 0.5 Euiin Extract 0.5 Preservatives, Colors and Flavors Quantity Purified water balance

1 is a graph showing the stability of the cationic / anionic surfactant mixed vesicle having a cationic composition containing the herbal extract according to the present invention.

2 is a graph showing the surface charge of a cationic / anionic surfactant mixed vesicle having a cationic composition containing the herbal extract according to the present invention.

Figure 3 is a graph showing the hair loss prevention effect of the cationic / anionic surfactant mixed vesicle having a cationic containing herbal extracts according to the present invention.

Figure 4 is a graph showing the hair growth effect of the cationic / anionic surfactant mixed vesicles containing the cationic extract according to the present invention.

Claims

A double-layered cationic / anionic surfactant mixed vesicle containing five or more herbal extracts selected from the group consisting of red ginseng, Angelica, cheonggung, licorice, wild chrysanthemum, and Euiin extracts is 0.1 to 0.2% by weight based on the total weight of the composition. Hair loss prevention or hair growth composition containing.

The composition according to claim 1, wherein the extracts of red ginseng, Angelica, cheonsugung, licorice, wild chrysanthemum or Euiyi are contained in an amount of 0.1 to 20% by weight based on the total weight of the composition.

The composition of claim 1, wherein the cationic / anionic surfactant mixed vesicle having a bilayer structure has a mole fraction of 0.45 to 0.90 and a mole fraction of anionic surfactant of 0.55 to 0.10.

The composition of claim 3, wherein the cationic surfactant is at least one selected from the group consisting of cetyltrimethylammonium chloride and octadecyltrimethylammonium chloride.

The composition of claim 3, wherein the anionic surfactant is at least one member selected from the group consisting of ammonium lauryl sulphate and sody laulauryl sulfate.

The composition of claim 1, wherein the composition is formulated as a hair tonic, a scalp treatment, a hair shampoo, a hair conditioner or a hair cream.