KR100664400B1 - Composition for preventing the hair from falling out - Google Patents

Composition for preventing the hair from falling out Download PDF

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KR100664400B1
KR100664400B1 KR1020050059110A KR20050059110A KR100664400B1 KR 100664400 B1 KR100664400 B1 KR 100664400B1 KR 1020050059110 A KR1020050059110 A KR 1020050059110A KR 20050059110 A KR20050059110 A KR 20050059110A KR 100664400 B1 KR100664400 B1 KR 100664400B1
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extract
hair
composition
hair loss
var
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KR1020050059110A
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Korean (ko)
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권승택
조웅천
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동아제약주식회사
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/882Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

Abstract

A composition for preventing hair loss and promoting hair growth is provided to clean and sterilize the scalp, protect the hair from outer environments, restore damaged hairs by supplying nutrients into the hairs, promote activation of hair root cells, and prevent hair loss by improving blood circulation of capillary vessel and controlling male hormone. The composition for preventing hair loss and promoting hair growth comprises the Hena(Lawsonia alba) extract, Emblica officinalis extract, Pueraria thunbergiana extract and Zingiber officinale extract, wherein the amount of Hena(Lawsonia alba) extract is 0.01-15 wt.% based on the total weight of solid contents in the composition; the composition further comprises Acorus var. calamus var. angustatus extract and green tea extract having inhibitory activity of 5 alpha-reductase; the amount of Acorus var. calamus var. angustatus extract and green tea extract is 0.01-15 wt.% based on the total weight of solid contents in the composition; and the composition further comprises the pine leaf extract.

Description

탈모예방 및 양모(養毛) 조성물{Composition for preventing the hair from falling out}Hair Loss Prevention and Wool Composition {Composition for preventing the hair from falling out}

도 1은 마우스를 이용한 발명조성물의 모발스코어 테스트 결과를 나타낸다. 1 shows a hair score test result of the invention composition using a mouse.

본 발명은 탈모 예방 및 양모 조성물에 관한 것으로서, 더욱 상세하게는 유효성분으로서 헤나 추출물을 함유하는 탈모예방 및 양모 조성물에 관한 것이다. The present invention relates to a hair loss prevention and wool composition, and more particularly to a hair loss prevention and wool composition containing henna extract as an active ingredient.

평균적으로 사람의 모발의 개수는 약 10만에서 12만 개이다. 모발은 발생, 성장, 퇴화, 휴지기라는 라이프 사이클이 있으며 휴지기에 돌입한 머리카락이 보통 하루에 50~100개 정도 빠지는 것이 정상이다. 모발은 일정기간 자라면 빠지고 새로운 모발이 난다. 손톱이나 발톱과는 달리 '자라고-쉬고-빠지고'하는 주기를 가지는 것이다. 털갈이를 하는 동물의 경우 전체 털의 모주기(毛週期)가 동일하기 때문에 털이 동시에 빠지고 새로 나는 이른바 털갈이를 하게 된다. 그러나 인간의 모발은 각각 독자적인 모주기를 갖고 있기 때문에 털갈이 없이 항상 일정한 모발 수를 유지하게 된다. On average, the number of human hair is about 100,000 to 120,000. Hair has a life cycle of development, growth, degeneration and rest periods, and it is normal for hair to enter the resting phase of 50-100 drops per day. The hair falls out after a certain period of time and new hair develops. Unlike nails and toenails, they have a cycle of 'growing-resting-falling'. In the case of molting animals, the hairs of all the hairs are the same, so the hairs fall out at the same time, and so-called molting. However, since human hair has its own hair cycle, it always maintains a constant hair count without molting.

인간 모발의 경우는 3년 자란 후 빠지고 다시 그 자리에서 3개월 후 새로 모발이 난다. 모발은 약 8만 개가 있으며 이 중 하루에 70여 개가 빠지며 3개월 전에 빠진 70여 개의 모발은 새로 자라나게 되어 모발은 항상 8만 개를 유지한다.In the case of human hair, after three years of growth, the hair falls out, and after three months, new hair is formed. There are about 80,000 hairs, of which 70 are lost a day, and about 70 hairs that were missing three months ago are newly growing, and the hair is always 80,000.

그러나 오늘날과 같이 바쁘게 살아가는 현대인들은 각종 스트레스를 받기 쉽다. 이러한 스트레스와 노화에 따른 영향이 탈모에 가장 밀접하게 작용을 한다. 과거 탈모는 유전에 의한 것이라 인식되었지만 최근 탈모는 노화의 한 현상이고 그 시기가 생활 환경의 변화에 따라 앞당겨진다는 점이 큰 문제이다. But today's busy people are vulnerable to stress. These stresses and the effects of aging work the most closely on hair loss. In the past, hair loss was recognized as genetic, but hair loss in recent years is a phenomenon of aging and a major problem is that the timing is accelerated by changes in living environment.

탈모증은 기본적으로 모발에너지를 만드는 기능, 즉 모발 에너지 사이클이 정상적으로 작용하지 못해 모근에 에너지 부족 현상이 생기기 때문에 발생되는 것으로 알려져 있다. Alopecia is known to occur mainly because of the function of producing hair energy, that is, the hair energy cycle does not work normally, resulting in energy shortage in the hair roots.

모발의 성장과 발육에 필요한 에너지의 생성을 방해한다고 알려진 남성호르몬(Androgen)의 일종인 테스토스테론(Testosteron)은 모낭 주변에 분포하고 있는 5 알파-리덕타아제의 작용으로 그 활성도가 보다 증가한 DHT(Dihydrotestosterone)로 변하게 된다. 활성화된 DHT는 안드로겐 수용체와 결합함으로써 모발의 성장기를 단축하고, 모낭의 크기를 위축시킴으로써 모발을 점차 가늘게 만들며 결국에는 탈모를 유발한다. Testosteron, a type of androgen known to hinder the growth and development of energy needed for hair growth, is the activity of 5 alpha-reductases distributed around the hair follicles. ). Activated DHT binds to androgen receptors, shortens the growth phase of the hair, shrinks the size of the hair follicles, thins the hair gradually and eventually causes hair loss.

탈모가 진행되면 모근에 존재하는 모유두가 작아지고 모발의 굵기도 가늘어지며 동시에 모주기가 짧아진다. 즉 3년 자란 후 빠져야 할 털이 1년 자란 후 빠지게 되면 계산적으로 하루에 210여 개가 빠지게 된다. 탈모가 계속 진행되면 모발은 솜털로 변하며 모주기는 더욱 짧아져 조금 자란 후 빠지게 되므로 모발이 가늘어지 고 길지 않게 된다. As hair loss progresses, the hair papilla present in the hair root becomes smaller, the thickness of the hair becomes thinner, and at the same time the hair cycle becomes shorter. In other words, after three years of hair growth to fall out after one year of hair growth is calculated to be about 210 dogs a day. If hair loss continues, the hair will turn down and the hair cycle will be shorter, and after a little overgrowth, the hair will become thinner and not longer.

따라서 남성호르몬을 조절할 수 있는 인자를 적용한다면 탈모가 예방될 것이라는 가정하에 의학계에서는 많은 연구를 거듭하여 탈모에 효과적인 신약을 개발하고 있다. 1997년 FDA에서 탈모치료제로 인정받은 남성호르몬 억제제인 프로페시아와 역시 전립선 비대증 치료제이면서 탈모예방에 효과적인 두타, 그리고 외용제이면서 항고혈압제인 미녹시딜은 가장 대표적인 탈모예방 및 발모제들이다. Therefore, under the assumption that applying a factor that regulates male hormones, hair loss will be prevented, and the medical community has been conducting a number of studies to develop new drugs effective for hair loss. Propecia, a male hormone inhibitor approved by the FDA in 1997, and duta, a prostate hypertrophy and effective anti-hair loss, and minoxidil, a topical and antihypertensive drug, are the most representative hair loss prevention and hair growth agents.

그러나 이러한 탈모예방제나 발모제를 적용할 경우 체내 항상성의 불균형으로 인하여 각종 부작용이 관찰되곤 하는데 대표적으로 성기능 감소나 알레르기, 우울증, 국소염증 등의 예기 하지 않은 각종 부작용이 발생한다. However, when applying such a hair loss prevention agent or hair regrowth agent, various side effects are observed due to the imbalance of homeostasis in the body, and typically various unexpected side effects such as decreased sexual function, allergy, depression, and local inflammation occur.

또한, 탈모는 복합적인 시스템으로 인해 발생하기 때문에 호르몬 억제 등의 협소적인 치료는 근시안적인 처방에 불과하다는 문제점이 있었다. In addition, since hair loss occurs due to a complex system, there is a problem that narrow treatment such as hormonal suppression is only myopic prescription.

이에 본 발명자들은 탈모방지 및 모발의 양모 효과를 극대화할 수 있는 각종 천연물들을 체계적이고 종합적으로 스크리닝한 결과 한가지 천연물이 아니라 복합적인 천연물만이 다각적인 탈모시스템에 효과적임을 확인하였다. 또한, 각각의 천연물 등의 최적 조성비를 설정하기 위하여 많은 시행착오 끝에 탈모 예방 및 양모에 효과적인 조성비를 얻게 되었다. Accordingly, the present inventors have systematically and comprehensively screened various natural products capable of preventing hair loss and maximizing the wool effect of hair, and confirmed that only natural products, not one natural products, are effective in a multifaceted hair loss system. In addition, in order to set the optimum composition ratio of each natural product, after a lot of trial and error, the composition ratio effective for preventing hair loss and wool was obtained.

상기와 같은 문제점을 해결하기 위하여 본 발명은 두피의 청결과 모발의 건강, 모근세포에 대한 에너지 공급, 원활한 혈행으로 인한 모근세포의 보호 등 복합 적인 처방으로서 안전성과 부작용이 전혀 없는 천연 식물 성분을 포함하는 탈모 예방 및 양모 조성물을 제공하고자 하는 것이다. In order to solve the above problems, the present invention includes a natural plant component that has no safety and side effects as a complex prescription such as cleanliness of the scalp and hair health, energy supply to the hair root cells, protection of the hair root cells due to smooth blood circulation. To prevent hair loss and to provide a wool composition.

상기 과제를 해결하기 위하여 본 발명은 유효성분으로서 헤나 추출물을 함유한다. In order to solve the above problems, the present invention contains a henna extract as an active ingredient.

즉 본 발명은 모발보호 및 보습, 두피 청결, 살균성분으로서 유효 성분인 헤나 추출물과 창포추출물을, 모근 자극성분으로 생강추출물과 솔잎추출물을, 모근세포로의 혈행촉진성분으로는 인디안구즈베리추출물과 트리블러스테레스트리스추출물을, 5 알파-리덕타제에 관련한 남성호로몬 작용성분으로는 갈근추출물과 녹차추출물을 포함한다. That is, the present invention is a henna extract and iris extract as active ingredients for hair protection and moisturizing, scalp cleanliness and sterilization, ginger extract and pine needle extract as hair root stimulating ingredients, and Indian gooseberry extract as blood circulation promoting ingredients to hair root cells. Triblersterless extract, and the male hormone function associated with 5 alpha-reductase, include root extract and green tea extract.

이하, 본 발명의 조성물에 함유되는 성분에 대하여 상세히 살펴보기로 한다.Hereinafter, the components contained in the composition of the present invention will be described in detail.

손상된 모발을 복원하고 모발에 영양을 공급하고 외부환경으로부터 모발을 보호하며, 두피 청결 및 살균성분인 헤나 추출물(Henna extract, Lawsonia alba)은 인도의 전승 의학인 아유르베다에 의해 몇천 년 전부터 피부병의 예방, 지혈, 부스럼, 화상, 타박상, 방부제, 피부염의 약제로 널리 사용돼 왔다. 오늘날에는 헤나가 헤어트리트먼트, 헤어컬러로서 이미 구미 지역에서부터 높이 평가되어 오면서 헤나의 잎의 "로소니아(LAWSONIA)"라는 주성분이 모발의 케라틴(단백질) 성분에 작용하여 염색, 광택 및 모발을 치유해주고, 항균·살균작용으로 두피의 노폐물을 밖으로 배출시켜 두피 질환(두피발진, 가려움증, 비듬 등)을 개선하며, 체온을 내려주는 효과가 있음이 알려져 있다. Restoring damaged hair, nourishing hair, protecting hair from the external environment, and Henna extract, Lawsonia alba, a scalp clean and disinfectant, has been prevented from skin diseases for thousands of years by Ayurveda, a traditional Indian medicine. It has been widely used as a medicine for hemostasis, swelling, burns, bruises, preservatives and dermatitis. Today, Henna has been highly regarded as a hair treatment and hair color from the European and American region, and the main ingredient, "LAWSONIA" of henna leaves acts on the hair's keratin (protein) component to cure pigmentation, gloss and hair. It is known that it is effective in reducing scalp diseases (scalp rash, itching, dandruff, etc.) by lowering the waste of scalp by antibacterial and antiseptic action.

또한, 유사한 작용을 하는 창포추출물 (蒼蒲, sweet flag, sweet rush, Acorus var. calamus var. angustatus)은 천남성목 천남성과로 여러해살이풀이며, 향포 및 왕창포라고도 한다. 뿌리줄기는 굵고 옆으로 뻗으며 마디가 많은데 밑부분에서 수염뿌리가 난다. 잎은 뿌리에서 모여나며 길이 70㎝, 나비 1-2㎝의 좁은 선형으로 가장자리가 밋밋하고 밑부분은 서로 얼싸안고, 연못가나 도랑가에서 자란다. 생약인 창포근(蒼蒲根)은 뿌리줄기를 말린 것이며 한방에서 기침, 거담, 두통, 구토 등의 약재로 쓰이고, 민간에서는 단옷날에 뿌리줄기와 잎을 삶아 머리를 감고 목욕을 하는 풍습이 있다. 양방에서는 뿌리줄기를 방향성 건위제로 쓴다. 붓꽃이나 꽃창포와 잎 모양은 비슷하나 전연 별종의 식물이다. 한국, 일본, 중국, 동부아시아, 시베리아 등지에 분포한다. In addition, iris extracts (蒼 蒲, sweet flag, sweet rush, Acorus var. Calamus var. Angustatus) that have a similar effect are perennial plants of Tiannamseong Mok Cheonnamseong, also known as Hyangpo and Wangchangpo. Root stocks are thick and stretched to the side, with many nodes, with beard roots at the bottom. The leaves are gathered from the roots and are narrow, 70cm long, 1-2cm of butterfly, with flat edges, and the bottom part embraces each other and grows in the pond or ditch. The herbal medicine, Changpo-geun (뿌리 根) is dried root stem and is used as a medicine such as cough, expectorant, headache, vomiting in oriental medicine. In both cases, the rhizome is used as a directional agent. Irises or irises are similar in shape to leaves but are stellar plants. It is distributed in Korea, Japan, China, Eastern Asia, and Siberia.

모근세포의 세포 활성화를 위한 혈행을 개선하는 성분인 인디안구즈베리추출물(Emblica officinalis)은 인도의 전통식물로 Amla라고 알려져 있다. 인도에서는 이 식물의 열매를 전래적으로 혈액을 정화하고 혈행을 개선하는데 사용하여 왔고, 구미 선진국에서는 이 열매를 이용한 혈액개선 제품이 많이 판매되고 있다. 이 열매에는 비타민 C가 풍부하고 합성 비타민 100mg에 해당하는 천연비타민 C가 함유되어 있다. Indian gooseberry extract (Emblica officinalis), an ingredient that improves blood circulation for cell activation of hair follicle cells, is known as Amla, a traditional plant of India. In India, the fruit of this plant has traditionally been used to purify blood and improve blood flow, and in Western countries, many of these fruits are sold. This fruit is rich in vitamin C and contains natural vitamin C, equivalent to 100 mg of synthetic vitamins.

또한, 인디안구즈베리와 유사한 작용을 하는 트리블러스테레스트리스추출물(남가새, 백질려, Tribulus terrestris L.)은 주로 바닷가의 모래땅이나 건조지에 자란다. 1~2년초로 줄기는 가지가 많이 갈라져서 땅 위를 기는데, 길이는 1m에 달하며 화경, 엽축과 더불어 털이 있다. 트리블러스의 주성분은 사포닌으로 우리나라에 인삼과 같이 외국에서는 이를 이용한 제품에 많이 사용된다. 주로 혈액개선이나 자양강장, 남성근력 보강에 이용되며, 인도의 전통식물 중에 하나이다. In addition, the Tribblester restless extract (N. vulgaris, Whitetail, Tribulus terrestris L.), which acts similar to Indian gooseberries, grows mainly on sandy beaches or in dry land. 1 ~ 2 years early, stem is divided into many branches and grows on the ground. Its length is 1m, and it has hairs along with flowers and leaf axes. The main component of the tribulus is saponin, which is widely used in foreign countries such as ginseng in Korea. It is mainly used for improving blood, nourishing tonic, and strengthening male muscle. It is one of the traditional plants of India.

탈모의 원인 중에 하나인 5 알파-리덕타제와 관련한 남성호르몬을 조절하는 성분으로 갈근추출물(Pueraria thunbergiana)을 사용하는데 이는 칡뿌리로서 우리나라에서 전래적으로 많이 섭취해온 식물 중에 하나이다. 콩에서 발견되는 천연호르몬인 이소플라본이 다량 함유되어 있어 남성호르몬 조절작용을 한다. 콩에서 발견되는 이소플라본과 다르게 다이드제인이 많아 남성호르몬 조절작용에 효과적이다. 한방에서는 간 보호와 감기, 당뇨, 해열, 진통 등의 처방에 많이 사용한다. One of the causes of hair loss, 5 alpha-reductase-related male hormone is used as a component to control the root extract (Pueraria thunbergiana), which is one of the plants that have been ingested in Korea as a root root. Isoflavones, a natural hormone found in soybeans, contain high amounts of male hormones. Unlike isoflavones found in soybeans, it is effective in regulating male hormones because it contains a lot of DyDane. In oriental medicine, it is often used for prescription of liver protection, cold, diabetes, fever and pain.

이와 유사한 작용을 하는 녹차추출물(Theasinensis L. var. sinensis L.)이 있는데 녹차는 예로부터 동양에서 건강을 위해 많이 장복한 건강차이다. 차에는 대표적인 화합물인 카페인, 카테킨 외에도 퓨린염기, 탄닌산, 단백질, 아미노산, 아미드 등이 함유되어 있다. 차에는 카페인이 평균 2-4% 함유되어 있으나 재배조건에 따라 크게 달라진다. 신경을 흥분시키고 혈액순환을 도우며 피로회복에 효능이 있다. There is a similar green tea extract (Theasinensis L. var. Sinensis L.), green tea has long been a health tea that has long been in good health in the East. Tea contains not only caffeine and catechins, which are representative compounds, but also purine base, tannic acid, protein, amino acid, and amide. Tea contains 2-4% caffeine on average, but it varies greatly depending on the growing conditions. It stimulates nerves, helps blood circulation, and is effective in recovering fatigue.

생강추출물(生薑, Zingiber officinale)은 인체 내에서 발한작용을 일으키고, 혈액순환을 촉진하며, 항염증과 진통에 효과가 있는 것으로 알려져 있다. 이러한 생강의 주요 기작 중 발한작용은 생강 자체의 방향성 성분이 나타내는 것으로서 두피에 바를 경우 두피 세포 속으로 스며들어 모근과 모낭 세포의 활발한 성장촉진을 야기하는 것으로 알려져 있다. Ginger extract (Zingiber officinale) is known to cause sweating in the human body, promote blood circulation, and is effective in anti-inflammatory and analgesic. Among the main mechanisms of ginger, the perspiration effect is indicated by the aromatic component of ginger itself, and when applied to the scalp, it is known to infiltrate the scalp cells and promote the active growth of hair follicles and hair follicle cells.

솔잎추출물(Pine leaf)은 풍습창을 다스리고 머리털을 나게 하며 오장을 편하게 하고 곡식대용으로 쓴다고 동의보감에서는 말하고 있다. 현대과학에서도 솔잎에 함유되어 있는 옥실팔티민산이 젊음을 유지시켜주는 강력한 작용을 한다고 밝히고 있다. 솔잎에는 비타민 A, C, K, 엽록소, 칼슘, 철분 등이 많이 함유되어 있다. 만성 빈혈환자에게 좋으며 담즙의 분비를 촉진시켜 노인성 치매를 예방하고 탈모 등에도 효과가 있다고 알려져 있다.Pine leaf extract is said to be used as a substitute for grain, to control the customary window, to make hair curls, and to ease the five sheets. Modern science also says that the oxyl palmitic acid contained in pine needles plays a powerful role in maintaining youth. Pine needles are high in vitamins A, C, K, chlorophyll, calcium and iron. It is good for patients with chronic anemia and is known to be effective in preventing geriatric dementia and promoting hair loss by promoting bile secretion.

본 발명의 조성물 마련을 위하여 헤나 추출물은 프로필렌글리콜 용액으로부터 추출하고, 또한 유사한 작용을 하는 창포추출물은 창포를 열수추출하여 얻었다. To prepare the composition of the present invention, henna extract was extracted from propylene glycol solution, and the iris extract having a similar function was obtained by hot water extraction of iris.

두피 및 모근 자극성분인 생강, 솔잎 등은 열수나 주정추출로부터 얻어졌고, 모근세포의 원활한 혈행개선을 하는 인디안구즈베리추출물과 트리블러스테레스트리스추출물 등은 원물을 열수추출, 감압농축, 수분 건조하여 얻어졌고, 남성호르몬 조절 인자인 갈근추출물은 열수추출, 감압 농축하여 얻고, 녹차추출물은 주정추출, 감압농축, 건조하여 얻었다. 또한, 본 발명의 조성물은 통상적인 모발 성장촉진 조성물로 사용되는 히노키티올, 고추팅크, 초산토코페롤, 니코틴산아미드, 살리실산, 엘-맨톨 등을 사용할 수 있다. Scalp and hair root irritants such as ginger and pine needles were obtained from hot water or alcohol extract, and Indian gooseberry extract and tribstersterless extract, which smoothly improve hair circulation of hair root cells, were extracted from hot water, concentrated under reduced pressure, and water dried. Root extract, which is a male hormone regulating factor, was obtained by hot water extraction and concentration under reduced pressure, and green tea extract was obtained by alcohol extraction, concentration under reduced pressure, and drying. In addition, the composition of the present invention can be used hinokithiol, pepper tincture, tocopherol acetate, nicotinic acid amide, salicylic acid, L- menthol and the like used as a conventional hair growth promoting composition.

본 발명의 제형화를 위해 사용할 수 있는 담체는 약제학적 분야에서 통상적인 것으로, 예를 들어 현탁제, 붕해제, 부형제, 가용화제, 안정화제, 현탁화제, 색소, 향료 등이 있으며, 본 발명의 탈모예방 및 양모 조성물은 바람직하게는 연고제, 로 숀제, 스프레이제 등의 국소적용제제로 제형화시켜 탈모 부위에 직접 작용하는 것이 효과적이다. 또한, 샴푸, 헤어컨디셔너, 헤어로션, 액상의 토닉형태, 비누, 크림 등 여러 가지 제형 등도 가능하다.Carriers that can be used for the formulation of the present invention are conventional in the pharmaceutical art, and include, for example, suspending agents, disintegrating agents, excipients, solubilizers, stabilizers, suspending agents, pigments, flavoring agents, and the like. The hair loss prevention and wool composition is preferably formulated with topical preparations such as ointments, lotions, sprays, and the like to act directly on the hair loss site. In addition, various formulations such as shampoos, hair conditioners, hair lotions, liquid tonic forms, soaps, and creams are also possible.

본 발명의 조성물에는 필요에 따라 양모 효과를 증진시킬 수 있는 하나 또는 그 이상의 추가 천연 성분을 포함할 수 있다. 이러한 목적으로 포함할 수 있는 성분으로는 검정콩추출물, 검은깨추출물, 한련초 추출물, 구기자추출물, 고삼추출물, 진피추출물 등이 있다. 이러한 추가 조성물이 포함되는 경우에 이들의 함량은 본 발명의 조성물의 총중량을 기준으로 하여 5-10% 이내가 되도록 하는 것이 좋다. The compositions of the present invention may include one or more additional natural ingredients that may enhance the wool effect as needed. Ingredients that can be included for this purpose include black soybean extract, black sesame extract, nasturtium extract, goji berry extract, red ginseng extract, dermis extract. Where such additional compositions are included, their content is preferably within 5-10% based on the total weight of the composition of the present invention.

<제조><Production>

본 발명의 조성물들의 제조는 위에 기술한 방법과 같이 원물을 잘 분쇄하여 열수추출, 주정추출, 프로필렌글리콜추출 등을 통해 얻고 감압농축하여 액상은 그대로 분말은 분말공정을 거쳐 얻었다.Preparation of the composition of the present invention by grinding the raw material as described above well through hot water extraction, alcohol extraction, propylene glycol extraction and concentrated under reduced pressure to obtain the liquid powder as it was through a powder process.

헤나 추출물의 함유량은 전체 고형분 대비 0.01-15중량%이 바람직하며, 갈근추출물 및 녹차추출물의 함량은 전체 고형분 대비 0.01-15중량%이 바람직하다.The content of henna extract is preferably 0.01-15% by weight relative to the total solids, the content of the root extract and green tea extract is preferably 0.01-15% by weight relative to the total solids.

본 발명의 통상적인 탈모예방 및 양모에 관한 식물복합 조성물의 액상타입 즉, 토닉 또는 샴푸에 관련한 조성비는 표1과 같다.Table 1 shows the composition ratios related to the liquid type, namely tonic or shampoo, of the plant complex composition related to conventional hair loss prevention and wool of the present invention.

(표 1)Table 1

성분ingredient 제조예1Preparation Example 1 제조예2Preparation Example 2 제조예3Preparation Example 3 제조예4Preparation Example 4 제조예5Preparation Example 5 비교예1Comparative Example 1 비교예2Comparative Example 2 헤나 추출물Henna extract 33 33 33 33 33 -- -* - * 창포추출물Iris extract -- 22 22 22 22 -- -- 인디안구즈베리Indian Gooseberry 추출물extract 1One 1One 1One 1One 1One -- -- 트리블러스테레스트리스추출Tribblesterless extraction water -- -- 1One 1One 1One -- -- 갈근추출물Root Extract 1One 1One 1One 1One 1One -- -- 녹차추출물Green Tea Extract -- -- -- 1One 1One -- -- 생강추출물Ginger Extract 1One 1One 1One 1One 1One -- -- 솔잎추출물Pine needle extract -- -- -- -- 1One -- -- 히노키티올Hinoki Thiol 0.10.1 0.10.1 0.10.1 0.10.1 0.10.1 0.10.1 -- 고추팅크Pepper tincture 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 -- 니코틴산아미드Nicotinic acid amide 0.50.5 0.50.5 0.50.5 0.50.5 0.50.5 0.50.5 -- 니코틴산벤질Benzyl nicotinate 0.010.01 0.010.01 0.010.01 0.010.01 0.010.01 0.010.01 -- 초산토코페롤Tocopherol Acetate 0.10.1 0.10.1 0.10.1 0.10.1 0.10.1 0.10.1 -- 살리실산Salicylic acid 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 -- 엘-맨톨L-Menthol 0.250.25 0.250.25 0.250.25 0.250.25 0.250.25 0.250.25 -- 트윈60Twin 60 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 -- 에탄올ethanol 3030 3030 3030 3030 3030 3030 3030 향료Spices 적량Quantity 적량Quantity 적량Quantity 적량Quantity 적량Quantity 적량Quantity 적량Quantity 정제수Purified water 잔량Remaining amount 잔량Remaining amount 잔량Remaining amount 잔량Remaining amount 잔량Remaining amount 잔량Remaining amount 잔량Remaining amount

*: 미녹시딜 3% *: Minoxidil 3%

이하, 첨부된 도면을 참조로 본 발명의 바람직한 실시예를 상세히 설명하기로 한다. 이에 앞서, 본 명세서 및 청구범위에 사용된 용어나 단어는 통상적이거나 사전적인 의미로 한정해서 해석되어서는 아니되며, 발명자는 그 자신의 발명을 가장 최선의 방법으로 설명하기 위해 용어의 개념을 적절하게 정의할 수 있다는 원칙에 입각하여 본 발명의 기술적 사상에 부합하는 의미와 개념으로 해석되어야 한다. Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms or words used in the specification and claims should not be construed as having a conventional or dictionary meaning, and the inventors should properly explain the concept of terms in order to best explain their own invention. Based on the principle that can be defined, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

따라서, 본 명세서에 기재된 실시예와 도면에 도시된 구성은 본 발명의 가장 바람직한 실시예에 불과할 뿐이고 본 발명의 기술적 사상을 모두 대변하는 것은 아니므로, 본 출원 시점에 있어서 이들을 대체할 수 있는 다양한 균등물과 변형예들이 있을 수 있음을 이해하여야 한다.Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various equivalents that may be substituted for them at the time of the present application It should be understood that there may be water and variations.

<실시예 1><Example 1>

본 발명의 최적 조성물과 조성비를 얻기 위해 동물실험을 이용한 모발스코어 테스트를 하였다. 생후 40-50일 된 체중 20-26그램의 마우스(C57BL/6, male)을 사용하여 실험을 하였다. 일정기간 적응기간이 지난 마우스의 등 부위의 털을 전기면도기를 이용하여 제거하고, 각 마우스의 무게를 측정하고 체중을 평균 내어 각 그룹당 12마리를 할당하여 그룹을 만들었다. 하루 동안 적응기간을 두고 다음날부터 제모 부위에 제조예1부터 5까지의 조성물과 비교예1부터 2까지의 조성물을 만들어 1일 1ml의 양으로 4주간 도포한 후 그 결과를 1주일 단위로 평가하였다. 평가척도는 모의 복원 정도 및 복원면적에 따라 완전 탈모 상태를 0으로 하고 모낭이 완전히 복원도 상태를 3으로 하며, 그 사이를 모낭의 길이 및 면적을 측정하여 0.5 단위로 세분하여 판정하였다. 그 결과는 표 2 및 도 1과 같다.In order to obtain the optimal composition and composition ratio of the present invention, a hair score test using an animal experiment was conducted. Experiments were performed using 20-26 grams of mice (C57BL / 6, male), 40-50 days old. After the period of adaptation, the hair on the back of the mouse was removed using an electric razor, each mouse was weighed and averaged, and 12 mice were allocated to each group. After the adaptation period for one day, the composition of Preparation Examples 1 to 5 and the compositions of Comparative Examples 1 to 2 were prepared on the hair removal site from the next day and then applied in an amount of 1 ml per day for 4 weeks, and the results were evaluated in units of 1 week. . According to the degree of restoration and the area of restoration, the degree of complete hair loss was set to 0, and the hair follicle was completely restored to 3, and the length and area of hair follicles were measured and subdivided into 0.5 units. The results are shown in Table 2 and FIG.

(표 2) 마우스를 이용한 발명조성물의 모발스코어 테스트 결과Table 2 Hair Score Test Results of Invention Compositions Using a Mouse

실험군Experimental group 일수Days 제조예1Preparation Example 1 제조예2Preparation Example 2 제조예3Preparation Example 3 제조예4Preparation Example 4 제조예5Preparation Example 5 비교예1Comparative Example 1 비교예2Comparative Example 2 0일0 days 00 00 00 00 00 00 00 7일7 days 0.030.03 0.050.05 0.050.05 0.060.06 0.080.08 0.020.02 0.040.04 14일14 days 0.20.2 0.350.35 0.40.4 0.550.55 0.70.7 0.10.1 0.250.25 21일21st 0.80.8 0.850.85 0.90.9 1.11.1 1.351.35 0.750.75 0.950.95 28일28 days 1.41.4 1.551.55 1.81.8 1.851.85 2.12.1 1.11.1 1.161.16 총합total 2.432.43 2.82.8 3.153.15 3.563.56 4.234.23 1.971.97 2.42.4

표 2와 도 1에서 보는 바와 같이 본 발명 조성물은 제조예5군이 가장 효능이 높은 것으로 나타났다. 제조예1군부터 제조예4군까지는 본 발명조성물의 종합시스템에서 한가지 성분들을 제외한 배합으로 실험을 한 것이다. 결과에서 본 바와 같이 본 조성물은 제조예5군이 가장 바람직한 것으로 나타났다. 또한, 비교예1군은 본 발명의 성분을 전혀 혼합하지 않은 조성물로 이 실험에서 가장 효력이 약한 것으로 나타났고, 비교예2군은 발모제로 판매되는 미녹시딜을 비교하여 실험한 것이다. 이상과 같이 제조예5군과 같은 최적의 조성물과 조성비가 탈모예방 및 양모에 관한 조성물로 가장 바람직함이 증명되었다. As shown in Table 2 and FIG. 1, the composition of the present invention was found to have the highest efficacy of the Preparation Example 5 group. Preparation Example 1 to Preparation Example 4 Groups were tested in the formulation except one component in the comprehensive system of the present invention composition. As seen from the results, the composition showed that Preparation 5 group was most preferred. In addition, the comparative example 1 group was found to be the most potent in this experiment with a composition that does not mix the components of the present invention, the comparative example 2 group was tested by comparing the minoxidil sold as a hair restorer. As described above, it was proved that the optimum composition and composition ratio as in Preparation Example 5 were the most preferable compositions for preventing hair loss and wool.

<실시예 2><Example 2>

본 발명의 조성물로 탈모증이 있는 대상자를 선정하여 임상실험을 하였다.Subjects with alopecia as a composition of the present invention were selected and subjected to clinical trials.

피험자는 35-55세까지의 탈모증이 있는 성인남녀 총 20명을 대상으로 남성 5명, 여성 5명을 한 그룹으로 나누어 1일 1회, 1회에 7ml씩 4개월간 탈모부위에 도포하여 그 결과를 관찰하였다.Subjects were divided into 5 groups of 5 males and 5 females in a group of 20 adult men and women with alopecia from 35 to 55 years of age and applied to the bald area for 7 months once a day for 7 months. Was observed.

효과의 판정은 세발시 일일 평균 탈모량, 육안판정소견 및 자각증상 개선 정도를 평가척도로써 5단계로 평가하고 종합적인 개선도를 상기 평가 척도의 평균으로 하였는데, 그 점수는 5점 만점으로 단계에 따라 1점 단위로 부여하였는데 표 3과 같다. 실험군은 제조예5군과 비교예1군으로 나누어 실시하였다.The evaluation of the effect was performed by five stages of evaluation of daily hair loss, visual judgment, and improvement of subjective symptoms at the time of trituration. According to 1 point unit is given in Table 3. The experimental group was divided into Preparation Example 5 group and Comparative Example 1 group.

(표 3) 본 발명의 조성물의 임상실험시 사용되는 점수 척도Table 3 Score Scale Used in Clinical Trials of Compositions of the Invention

판정 점수Judgment score 육안판정Visual judgment 자각증상Subjective symptoms 세발시 탈모수Hair loss at tricycle 1One 악화worse 악화worse 증가increase 22 불변immutability 불변immutability 불변immutability 33 조금 개선Little improvement 조금 개선Little improvement 조금 감소Little decrease 44 중간 개선Medium improvement 중간 개선Medium improvement 중간 감소Medium reduction 55 많이 개선Much improvement 많이 개선Much improvement 많이 감소Much reduced

(표 4) 본 발명의 조성물의 임상실험 결과Table 4 Clinical Trial Results of Compositions of the Invention

실험군 판정      Experiment group judgment 제조예5 Preparation Example 5 비교예1 Comparative Example 1 비고Remarks 육안판정Visual judgment 3.83.8 2.12.1 44% 개선효과44% improvement 자각증상Subjective symptoms 3.93.9 2.52.5 36% 개선효과36% improvement 세발시 탈모수Hair loss at tricycle 4.34.3 2.22.2 49% 개선효과49% improvement 종합개선Comprehensive Improvement 4.04.0 2.262.26 44% 개선효과44% improvement

본 발명의 조성물의 임상실험 결과는 표 4에서 보는 바와 같이 비교예1군에 비해 제조예5군은 육안판정, 자각증상, 세발시 탈모수에 있어서 36-49%의 탈모 개선효과를 보였다. 종합적인 개선도를 산정해보면 평균 44%의 개선효과가 있는 것으 로 나타났다.Clinical results of the composition of the present invention as shown in Table 4 Preparation Example 5 compared to Comparative Example 1 group showed a hair loss improvement effect of 36-49% in gross judgment, subjective symptoms, hair loss during trituration. The overall improvement was estimated to be 44% on average.

이상과 같이, 본 발명은 비록 한정된 실시예와 도면에 의해 설명되었으나, 본 발명은 이것에 의해 한정되지 않으며 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 본 발명의 기술 사상과 아래에 기재될 특허 청구범위의 균등 범위 내에서 다양한 수정 및 변형이 가능함은 물론이다.  As mentioned above, although this invention was demonstrated by the limited embodiment and drawing, this invention is not limited by this, The person of ordinary skill in the art to which this invention belongs, Of course, various modifications and variations are possible within the scope of equivalent claims.

본 발명은 본 발명에 포함된 조성물들은 탈모의 다양한 원인을 체계적으로 접근 치유한다고 할 수 있다. The present invention can be said that the compositions included in the present invention systematically heal various causes of hair loss.

본 발명은 탈모예방 및 양모에 관한 조성물에 관한 것으로 탈모의 원인이 여러 가지인 점에 착안하여 모발, 모근세포, 호르몬, 혈행, 두피 등 다각적인 시스템으로 접근한 것으로 종합적으로 탈모 유발을 일으키는 원인에 대해서 효과적으로 작용하여 탈모예방 및 양모에 대해서 우수한 효과를 나타낸다는 것을 동물실험과 임상실험을 통하여 증명하였다. The present invention relates to a composition for preventing hair loss and wool, focusing on various causes of hair loss, and approaching a multifaceted system such as hair, hair root cells, hormones, blood circulation, and scalp to comprehensively cause hair loss. It has been proved through animal and clinical experiments that it is effective in preventing hair loss and showing excellent effects on wool.

즉 본 발명은 천연식물의 복합 조성물로 의약품으로 판매되는 치료제에 비해 부작용이 거의 없고 손상된 모발의 복원 및 영양공급, 모근세포의 활성화, 모근세포로의 혈행개선 증진, 5 알파-리덕타제와 관련한 남성호르몬 조절작용과 두피 청결 및 살균 작용, 모근 및 두피 자극 작용을 통한 자율신경의 정상화 등을 꾀해 탈모예방 및 양모에 효과가 있다.In other words, the present invention is a complex composition of natural plants, compared to the therapeutic drugs sold as pharmaceuticals, has little side effects and restores and nourishes damaged hair, activates hair root cells, improves blood circulation to hair root cells, and 5 alpha-reductase-related men. Hormonal regulation, scalp cleansing and bactericidal effect, normalization of autonomic nerve through hair root and scalp stimulation effect, is effective in preventing hair loss and wool.

Claims (9)

헤나 추출물, 인디안구즈베리추출물, 갈근추출물 및 생강추출물을 함유하는 탈모예방 및 양모 조성물. Hair loss prevention and wool composition containing henna extract, Indian gooseberry extract, root extract and ginger extract. 제 1 항에 있어서,  The method of claim 1, 상기 헤나 추출물의 함유량은 전체 고형분 대비 0.01-15중량%인 조성물.The henna extract content is 0.01-15% by weight based on the total solids. 제 2 항에 있어서,  The method of claim 2, 창포추출물을 더 포함하는 조성물.Composition comprising a iris extract. 제 3 항에 있어서, The method of claim 3, wherein 트리블러스테레스트리스추출물을 더 포함하는 조성물.The composition further comprises a tribester restless extract. 제 4 항에 있어서,  The method of claim 4, wherein 5 알파-리덕타제 활성 억제 성분인 녹차추출물을 더 포함하는 조성물.5 Alpha-reductase activity inhibitory composition further comprises a green tea extract. 삭제delete 제 5 항에 있어서, The method of claim 5, 상기 갈근추출물 및 녹차추출물의 함량은 전체 고형분 대비 0.01-15중량%인 조성물.The composition of the root extract and green tea extract is 0.01-15% by weight relative to the total solids. 제 7 항에 있어서, The method of claim 7, wherein 솔잎추출물을 더 포함하는 조성물.The composition further comprises a pine needle extract. 제 8 항에 있어서, The method of claim 8, 히노키티올, 고추팅크, 니코틴산아미드, 니코틴산벤질, 초산토코페롤, 살리실산, 엘-맨톨, 트윈60 및 에탄올을 더 포함하는 조성물.A composition further comprising hinokithiol, pepper tincture, nicotinic acid amide, nicotinic acid benzyl, tocopherol acetate, salicylic acid, L-menthol, tween 60 and ethanol.
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KR100772993B1 (en) 2007-02-27 2007-11-05 김운심 Hair growing promotor and method for producing the same
CN105106091A (en) * 2015-08-31 2015-12-02 殷志杰 Antidandruff, antipruritic and haircare shampoo
GB2541158A (en) * 2015-07-03 2017-02-15 Stigma Inc Composition
WO2017043669A1 (en) * 2015-09-07 2017-03-16 주식회사 에디쁘 Dye using natural henna
WO2018021847A1 (en) * 2016-07-29 2018-02-01 주식회사 티젠 농업회사법인 Composition for preventing hair loss or stimulating hair growth, containing amla extract
CN111803426A (en) * 2020-07-17 2020-10-23 广州市逸轩精细化工有限公司 Anti-hair loss and hair-fixing nutrient solution and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100772993B1 (en) 2007-02-27 2007-11-05 김운심 Hair growing promotor and method for producing the same
GB2541158A (en) * 2015-07-03 2017-02-15 Stigma Inc Composition
CN105106091A (en) * 2015-08-31 2015-12-02 殷志杰 Antidandruff, antipruritic and haircare shampoo
WO2017043669A1 (en) * 2015-09-07 2017-03-16 주식회사 에디쁘 Dye using natural henna
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CN111803426A (en) * 2020-07-17 2020-10-23 广州市逸轩精细化工有限公司 Anti-hair loss and hair-fixing nutrient solution and preparation method thereof

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