KR100664400B1 - Composition for preventing the hair from falling out - Google Patents

Abstract

A composition for preventing hair loss and promoting hair growth is provided to clean and sterilize the scalp, protect the hair from outer environments, restore damaged hairs by supplying nutrients into the hairs, promote activation of hair root cells, and prevent hair loss by improving blood circulation of capillary vessel and controlling male hormone. The composition for preventing hair loss and promoting hair growth comprises the Hena(Lawsonia alba) extract, Emblica officinalis extract, Pueraria thunbergiana extract and Zingiber officinale extract, wherein the amount of Hena(Lawsonia alba) extract is 0.01-15 wt.% based on the total weight of solid contents in the composition; the composition further comprises Acorus var. calamus var. angustatus extract and green tea extract having inhibitory activity of 5 alpha-reductase; the amount of Acorus var. calamus var. angustatus extract and green tea extract is 0.01-15 wt.% based on the total weight of solid contents in the composition; and the composition further comprises the pine leaf extract.

Description

Hair Loss Prevention and Wool Composition {Composition for preventing the hair from falling out}

1 shows a hair score test result of the invention composition using a mouse.

The present invention relates to a hair loss prevention and wool composition, and more particularly to a hair loss prevention and wool composition containing henna extract as an active ingredient.

On average, the number of human hair is about 100,000 to 120,000. Hair has a life cycle of development, growth, degeneration and rest periods, and it is normal for hair to enter the resting phase of 50-100 drops per day. The hair falls out after a certain period of time and new hair develops. Unlike nails and toenails, they have a cycle of 'growing-resting-falling'. In the case of molting animals, the hairs of all the hairs are the same, so the hairs fall out at the same time, and so-called molting. However, since human hair has its own hair cycle, it always maintains a constant hair count without molting.

In the case of human hair, after three years of growth, the hair falls out, and after three months, new hair is formed. There are about 80,000 hairs, of which 70 are lost a day, and about 70 hairs that were missing three months ago are newly growing, and the hair is always 80,000.

But today's busy people are vulnerable to stress. These stresses and the effects of aging work the most closely on hair loss. In the past, hair loss was recognized as genetic, but hair loss in recent years is a phenomenon of aging and a major problem is that the timing is accelerated by changes in living environment.

Alopecia is known to occur mainly because of the function of producing hair energy, that is, the hair energy cycle does not work normally, resulting in energy shortage in the hair roots.

Testosteron, a type of androgen known to hinder the growth and development of energy needed for hair growth, is the activity of 5 alpha-reductases distributed around the hair follicles. ). Activated DHT binds to androgen receptors, shortens the growth phase of the hair, shrinks the size of the hair follicles, thins the hair gradually and eventually causes hair loss.

As hair loss progresses, the hair papilla present in the hair root becomes smaller, the thickness of the hair becomes thinner, and at the same time the hair cycle becomes shorter. In other words, after three years of hair growth to fall out after one year of hair growth is calculated to be about 210 dogs a day. If hair loss continues, the hair will turn down and the hair cycle will be shorter, and after a little overgrowth, the hair will become thinner and not longer.

Therefore, under the assumption that applying a factor that regulates male hormones, hair loss will be prevented, and the medical community has been conducting a number of studies to develop new drugs effective for hair loss. Propecia, a male hormone inhibitor approved by the FDA in 1997, and duta, a prostate hypertrophy and effective anti-hair loss, and minoxidil, a topical and antihypertensive drug, are the most representative hair loss prevention and hair growth agents.

However, when applying such a hair loss prevention agent or hair regrowth agent, various side effects are observed due to the imbalance of homeostasis in the body, and typically various unexpected side effects such as decreased sexual function, allergy, depression, and local inflammation occur.

In addition, since hair loss occurs due to a complex system, there is a problem that narrow treatment such as hormonal suppression is only myopic prescription.

Accordingly, the present inventors have systematically and comprehensively screened various natural products capable of preventing hair loss and maximizing the wool effect of hair, and confirmed that only natural products, not one natural products, are effective in a multifaceted hair loss system. In addition, in order to set the optimum composition ratio of each natural product, after a lot of trial and error, the composition ratio effective for preventing hair loss and wool was obtained.

In order to solve the above problems, the present invention includes a natural plant component that has no safety and side effects as a complex prescription such as cleanliness of the scalp and hair health, energy supply to the hair root cells, protection of the hair root cells due to smooth blood circulation. To prevent hair loss and to provide a wool composition.

In order to solve the above problems, the present invention contains a henna extract as an active ingredient.

That is, the present invention is a henna extract and iris extract as active ingredients for hair protection and moisturizing, scalp cleanliness and sterilization, ginger extract and pine needle extract as hair root stimulating ingredients, and Indian gooseberry extract as blood circulation promoting ingredients to hair root cells. Triblersterless extract, and the male hormone function associated with 5 alpha-reductase, include root extract and green tea extract.

Hereinafter, the components contained in the composition of the present invention will be described in detail.

Restoring damaged hair, nourishing hair, protecting hair from the external environment, and Henna extract, Lawsonia alba, a scalp clean and disinfectant, has been prevented from skin diseases for thousands of years by Ayurveda, a traditional Indian medicine. It has been widely used as a medicine for hemostasis, swelling, burns, bruises, preservatives and dermatitis. Today, Henna has been highly regarded as a hair treatment and hair color from the European and American region, and the main ingredient, "LAWSONIA" of henna leaves acts on the hair's keratin (protein) component to cure pigmentation, gloss and hair. It is known that it is effective in reducing scalp diseases (scalp rash, itching, dandruff, etc.) by lowering the waste of scalp by antibacterial and antiseptic action.

In addition, iris extracts (蒼 蒲, sweet flag, sweet rush, Acorus var. Calamus var. Angustatus) that have a similar effect are perennial plants of Tiannamseong Mok Cheonnamseong, also known as Hyangpo and Wangchangpo. Root stocks are thick and stretched to the side, with many nodes, with beard roots at the bottom. The leaves are gathered from the roots and are narrow, 70cm long, 1-2cm of butterfly, with flat edges, and the bottom part embraces each other and grows in the pond or ditch. The herbal medicine, Changpo-geun (뿌리 根) is dried root stem and is used as a medicine such as cough, expectorant, headache, vomiting in oriental medicine. In both cases, the rhizome is used as a directional agent. Irises or irises are similar in shape to leaves but are stellar plants. It is distributed in Korea, Japan, China, Eastern Asia, and Siberia.

Indian gooseberry extract (Emblica officinalis), an ingredient that improves blood circulation for cell activation of hair follicle cells, is known as Amla, a traditional plant of India. In India, the fruit of this plant has traditionally been used to purify blood and improve blood flow, and in Western countries, many of these fruits are sold. This fruit is rich in vitamin C and contains natural vitamin C, equivalent to 100 mg of synthetic vitamins.

In addition, the Tribblester restless extract (N. vulgaris, Whitetail, Tribulus terrestris L.), which acts similar to Indian gooseberries, grows mainly on sandy beaches or in dry land. 1 ~ 2 years early, stem is divided into many branches and grows on the ground. Its length is 1m, and it has hairs along with flowers and leaf axes. The main component of the tribulus is saponin, which is widely used in foreign countries such as ginseng in Korea. It is mainly used for improving blood, nourishing tonic, and strengthening male muscle. It is one of the traditional plants of India.

One of the causes of hair loss, 5 alpha-reductase-related male hormone is used as a component to control the root extract (Pueraria thunbergiana), which is one of the plants that have been ingested in Korea as a root root. Isoflavones, a natural hormone found in soybeans, contain high amounts of male hormones. Unlike isoflavones found in soybeans, it is effective in regulating male hormones because it contains a lot of DyDane. In oriental medicine, it is often used for prescription of liver protection, cold, diabetes, fever and pain.

There is a similar green tea extract (Theasinensis L. var. Sinensis L.), green tea has long been a health tea that has long been in good health in the East. Tea contains not only caffeine and catechins, which are representative compounds, but also purine base, tannic acid, protein, amino acid, and amide. Tea contains 2-4% caffeine on average, but it varies greatly depending on the growing conditions. It stimulates nerves, helps blood circulation, and is effective in recovering fatigue.

Ginger extract (Zingiber officinale) is known to cause sweating in the human body, promote blood circulation, and is effective in anti-inflammatory and analgesic. Among the main mechanisms of ginger, the perspiration effect is indicated by the aromatic component of ginger itself, and when applied to the scalp, it is known to infiltrate the scalp cells and promote the active growth of hair follicles and hair follicle cells.

Pine leaf extract is said to be used as a substitute for grain, to control the customary window, to make hair curls, and to ease the five sheets. Modern science also says that the oxyl palmitic acid contained in pine needles plays a powerful role in maintaining youth. Pine needles are high in vitamins A, C, K, chlorophyll, calcium and iron. It is good for patients with chronic anemia and is known to be effective in preventing geriatric dementia and promoting hair loss by promoting bile secretion.

To prepare the composition of the present invention, henna extract was extracted from propylene glycol solution, and the iris extract having a similar function was obtained by hot water extraction of iris.

Scalp and hair root irritants such as ginger and pine needles were obtained from hot water or alcohol extract, and Indian gooseberry extract and tribstersterless extract, which smoothly improve hair circulation of hair root cells, were extracted from hot water, concentrated under reduced pressure, and water dried. Root extract, which is a male hormone regulating factor, was obtained by hot water extraction and concentration under reduced pressure, and green tea extract was obtained by alcohol extraction, concentration under reduced pressure, and drying. In addition, the composition of the present invention can be used hinokithiol, pepper tincture, tocopherol acetate, nicotinic acid amide, salicylic acid, L- menthol and the like used as a conventional hair growth promoting composition.

Carriers that can be used for the formulation of the present invention are conventional in the pharmaceutical art, and include, for example, suspending agents, disintegrating agents, excipients, solubilizers, stabilizers, suspending agents, pigments, flavoring agents, and the like. The hair loss prevention and wool composition is preferably formulated with topical preparations such as ointments, lotions, sprays, and the like to act directly on the hair loss site. In addition, various formulations such as shampoos, hair conditioners, hair lotions, liquid tonic forms, soaps, and creams are also possible.

The compositions of the present invention may include one or more additional natural ingredients that may enhance the wool effect as needed. Ingredients that can be included for this purpose include black soybean extract, black sesame extract, nasturtium extract, goji berry extract, red ginseng extract, dermis extract. Where such additional compositions are included, their content is preferably within 5-10% based on the total weight of the composition of the present invention.

<Production>

Preparation of the composition of the present invention by grinding the raw material as described above well through hot water extraction, alcohol extraction, propylene glycol extraction and concentrated under reduced pressure to obtain the liquid powder as it was through a powder process.

The content of henna extract is preferably 0.01-15% by weight relative to the total solids, the content of the root extract and green tea extract is preferably 0.01-15% by weight relative to the total solids.

Table 1 shows the composition ratios related to the liquid type, namely tonic or shampoo, of the plant complex composition related to conventional hair loss prevention and wool of the present invention.

Table 1

ingredient Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 Comparative Example 1 Comparative Example 2 Henna extract 3 3 3 3 3 - - ^* Iris extract - 2 2 2 2 - - Indian Gooseberry extract One One One One One - - Tribblesterless extraction water - - One One One - - Root Extract One One One One One - - Green Tea Extract - - - One One - - Ginger Extract One One One One One - - Pine needle extract - - - - One - - Hinoki Thiol 0.1 0.1 0.1 0.1 0.1 0.1 - Pepper tincture 0.4 0.4 0.4 0.4 0.4 0.4 - Nicotinic acid amide 0.5 0.5 0.5 0.5 0.5 0.5 - Benzyl nicotinate 0.01 0.01 0.01 0.01 0.01 0.01 - Tocopherol Acetate 0.1 0.1 0.1 0.1 0.1 0.1 - Salicylic acid 0.3 0.3 0.3 0.3 0.3 0.3 - L-Menthol 0.25 0.25 0.25 0.25 0.25 0.25 - Twin 60 0.4 0.4 0.4 0.4 0.4 0.4 - ethanol 30 30 30 30 30 30 30 Spices Quantity Quantity Quantity Quantity Quantity Quantity Quantity Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

*: Minoxidil 3%

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms or words used in the specification and claims should not be construed as having a conventional or dictionary meaning, and the inventors should properly explain the concept of terms in order to best explain their own invention. Based on the principle that can be defined, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various equivalents that may be substituted for them at the time of the present application It should be understood that there may be water and variations.

<Example 1>

In order to obtain the optimal composition and composition ratio of the present invention, a hair score test using an animal experiment was conducted. Experiments were performed using 20-26 grams of mice (C57BL / 6, male), 40-50 days old. After the period of adaptation, the hair on the back of the mouse was removed using an electric razor, each mouse was weighed and averaged, and 12 mice were allocated to each group. After the adaptation period for one day, the composition of Preparation Examples 1 to 5 and the compositions of Comparative Examples 1 to 2 were prepared on the hair removal site from the next day and then applied in an amount of 1 ml per day for 4 weeks, and the results were evaluated in units of 1 week. . According to the degree of restoration and the area of restoration, the degree of complete hair loss was set to 0, and the hair follicle was completely restored to 3, and the length and area of hair follicles were measured and subdivided into 0.5 units. The results are shown in Table 2 and FIG.

Table 2 Hair Score Test Results of Invention Compositions Using a Mouse

Experimental group Days Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 Comparative Example 1 Comparative Example 2 0 days 0 0 0 0 0 0 0 7 days 0.03 0.05 0.05 0.06 0.08 0.02 0.04 14 days 0.2 0.35 0.4 0.55 0.7 0.1 0.25 21st 0.8 0.85 0.9 1.1 1.35 0.75 0.95 28 days 1.4 1.55 1.8 1.85 2.1 1.1 1.16 total 2.43 2.8 3.15 3.56 4.23 1.97 2.4

As shown in Table 2 and FIG. 1, the composition of the present invention was found to have the highest efficacy of the Preparation Example 5 group. Preparation Example 1 to Preparation Example 4 Groups were tested in the formulation except one component in the comprehensive system of the present invention composition. As seen from the results, the composition showed that Preparation 5 group was most preferred. In addition, the comparative example 1 group was found to be the most potent in this experiment with a composition that does not mix the components of the present invention, the comparative example 2 group was tested by comparing the minoxidil sold as a hair restorer. As described above, it was proved that the optimum composition and composition ratio as in Preparation Example 5 were the most preferable compositions for preventing hair loss and wool.

<Example 2>

Subjects with alopecia as a composition of the present invention were selected and subjected to clinical trials.

Subjects were divided into 5 groups of 5 males and 5 females in a group of 20 adult men and women with alopecia from 35 to 55 years of age and applied to the bald area for 7 months once a day for 7 months. Was observed.

The evaluation of the effect was performed by five stages of evaluation of daily hair loss, visual judgment, and improvement of subjective symptoms at the time of trituration. According to 1 point unit is given in Table 3. The experimental group was divided into Preparation Example 5 group and Comparative Example 1 group.

Table 3 Score Scale Used in Clinical Trials of Compositions of the Invention

Judgment score Visual judgment Subjective symptoms Hair loss at tricycle One worse worse increase 2 immutability immutability immutability 3 Little improvement Little improvement Little decrease 4 Medium improvement Medium improvement Medium reduction 5 Much improvement Much improvement Much reduced

Table 4 Clinical Trial Results of Compositions of the Invention

      Experiment group judgment Preparation Example 5 Comparative Example 1 Remarks Visual judgment 3.8 2.1 44% improvement Subjective symptoms 3.9 2.5 36% improvement Hair loss at tricycle 4.3 2.2 49% improvement Comprehensive Improvement 4.0 2.26 44% improvement

Clinical results of the composition of the present invention as shown in Table 4 Preparation Example 5 compared to Comparative Example 1 group showed a hair loss improvement effect of 36-49% in gross judgment, subjective symptoms, hair loss during trituration. The overall improvement was estimated to be 44% on average.

 As mentioned above, although this invention was demonstrated by the limited embodiment and drawing, this invention is not limited by this, The person of ordinary skill in the art to which this invention belongs, Of course, various modifications and variations are possible within the scope of equivalent claims.

The present invention can be said that the compositions included in the present invention systematically heal various causes of hair loss.

The present invention relates to a composition for preventing hair loss and wool, focusing on various causes of hair loss, and approaching a multifaceted system such as hair, hair root cells, hormones, blood circulation, and scalp to comprehensively cause hair loss. It has been proved through animal and clinical experiments that it is effective in preventing hair loss and showing excellent effects on wool.

In other words, the present invention is a complex composition of natural plants, compared to the therapeutic drugs sold as pharmaceuticals, has little side effects and restores and nourishes damaged hair, activates hair root cells, improves blood circulation to hair root cells, and 5 alpha-reductase-related men. Hormonal regulation, scalp cleansing and bactericidal effect, normalization of autonomic nerve through hair root and scalp stimulation effect, is effective in preventing hair loss and wool.

Claims (9)

Hair loss prevention and wool composition containing henna extract, Indian gooseberry extract, root extract and ginger extract.  The method of claim 1, The henna extract content is 0.01-15% by weight based on the total solids.  The method of claim 2, Composition comprising a iris extract. The method of claim 3, wherein The composition further comprises a tribester restless extract.  The method of claim 4, wherein 5 Alpha-reductase activity inhibitory composition further comprises a green tea extract. delete The method of claim 5, The composition of the root extract and green tea extract is 0.01-15% by weight relative to the total solids. The method of claim 7, wherein The composition further comprises a pine needle extract. The method of claim 8, A composition further comprising hinokithiol, pepper tincture, nicotinic acid amide, nicotinic acid benzyl, tocopherol acetate, salicylic acid, L-menthol, tween 60 and ethanol.

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