KR101744103B1 - Composition for preventing hair loss and promoting hair growth and mathod for preparing the same - Google Patents

Abstract

The present invention relates to a method for preparing a mixture 100 g of the mixture of ginseng, Angelica gigas, Angelica keiskei koidz., And a mixture of herbaceous moths and herbaceous mosses at a weight ratio of 1: 3: 1 to 3: 1 to 3, 30 to 70% by weight of a concentrate concentrated to 200 to 500 parts by weight based on parts by weight; And
3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 10 to 30 parts by weight of brown sugar and 80 to 200 parts by weight of water are added to a fermentation tank based on 100 parts by weight of a mixture obtained by mixing 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3 by weight. Saccharomyces spp And 30 to 70% by weight of a fermented product obtained by inoculating the strain and fermented at 20 to 40 ° C for 2 to 4 months. The present invention also provides a composition for promoting hair loss prevention and hair growth, and a method of producing the same.

Description

Technical Field [0001] The present invention relates to a composition for preventing hair loss and promoting hair growth,

The present invention relates to a composition for preventing hair loss and for promoting hair growth and a method for producing the same.

In recent years, the number of people who are suffering from hair loss due to changes in diet and stress has increased, the age is lower, and the number of female hair loss is increasing.

Among the causes of alopecia, the most common type directly related to male hormone excess secretion is androgenic alopecia, commonly referred to as male pattern baldness. In the case of androgenetic alopecia, healthy hair becomes tapered and shortened, hair becomes weak and easily broken, which is called miniaturization. The hair follicles that undergo miniaturization eventually become thin and invisible and turn into short fur, resulting in hair loss.

Recently, many studies have been conducted to prevent and treat hair loss through inhibition of male hormone activity. Male alopecia are caused by the conversion of testosterone, one of the male hormones, into dihydrotestosterone (DHT), an active male hormone, by 5-alpha-reductase, and this activated dihydrotestosterone is converted to androgen It binds to the receptor to delay the protein synthesis of the hair follicle, shortening the growth period of the hair follicle, and atrophying the hair follicle. In addition, sebaceous hyperplasia is produced in the process of androgenetic alopecia. As a result, hair loss accompanying inflammation may appear in the scalp,

Although it is known that female hair loss is much more diverse than male hair loss, androgenetic hair loss caused by the inheritance of sex hormones is responsible for about 50% of adult female hair loss.

The male alopecia caused by the excessive production of dihydrotestosterone (DHT) by the action of 5-alpha reductase may utilize the anti-androgen activity effect which inhibits the activity of 5-alpha reductase or inhibits the binding with the androgen receptor Suggesting that the use of androgens to promote estrogen conversion may effectively prevent and treat androgenetic alopecia.

Transforming Growth Factor-beta (TGF-β) plays an important role among the growth factors affecting hair growth and cycle. TGF-β induces apoptosis in the living body, thereby inducing the regression of hair follicles. Several studies have reported that TGF-β inhibits hair follicle growth, since Philpott et al. Reported that adding TGF-β1 to culture media inhibited hair follicle growth when cultured human hair follicles.

When 5-alpha reductase is activated, it is known that the synthesis of dihydrotestosterone (DHT) is increased, thereby promoting TGF-beta biosynthesis as a lower signaling substance, thereby promoting hair loss.

Based on the above rationale, the proposed drug is called Propecia, which is commercially available from Merck Pharmaceuticals, USA. Finasteride, a major component of the drug, shows a mechanism to inhibit the conversion of the male hormone testosterone into a potent form of the active male hormone dihydrotestosterone (DHT). Propecia was approved for use in the United States by the US FDA in 1997 for the treatment of active alopecia. However, several months after taking the effect of the effect is manifested, such as diminished libido, erectile dysfunction and has the disadvantage of side effects. In addition, there is a disadvantage that only men are available, the stability of women and children is not established, and the use of pregnant women or women who are pregnant is prohibited.

In addition, Minoxidil is the most widely used drug for the treatment and prevention of alopecia, which is approved by the FDA as an agent to promote regrowth of hair developed by Pharmacia of USA. Minoxidil is a medicine to be applied. It is effective in some cases when the subject is young, oily, and the ovary is missing. In other cases, however, it shows not only a slight effect, but also contact dermatitis or dry mouth, hypotension, Have been reported.

In order to solve the above-mentioned problem of side effects, studies on hair growth using natural materials have been actively conducted. Korean Patent No. 10-0348155 (Aug. 8, 2002) discloses a hair growth composition containing a wild mushroom extract and a preparation method thereof. Although the hair growth inhibitor composition is advantageous in that it has no side effects, there is a problem that hair loss prevention and hair growth promoting effect are not sufficient.

Korean Patent No. 10-0348155

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned disadvantages of the prior art,

It is an object of the present invention to provide a composition for preventing hair loss and promoting hair growth, which is composed of a natural component and has no fear of side effects such as finasteride and minoxidil, and is excellent in preventing hair loss and promoting hair growth.

The present invention, in order to achieve the above object,

Ginseng; Angelica; Wherein the mixture is prepared by mixing 500-1,000 parts by weight of water based on 100 parts by weight of the mixture, and adding the extracted hot-water extract to 200-500 weight parts 30 to 70% by weight of a concentrate concentrated in part; And

3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: And 30 to 70% by weight of a fermented product fermented at 20 to 40 DEG C for 2 to 4 months.

The composition for preventing hair loss and for promoting hair growth comprises 100 parts by weight of the composition

300 to 700 parts by weight of water are added to 100 parts by weight of the mixture, and the mixture is heated to a temperature of 1 to 3: 1 to 3: 1 to 3: 1 to 3, The concentrate obtained by concentrating the extracted hot-water extract to 150-300 parts by weight and the sugar source 5-20 parts by weight are put into a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast and fermented at 20-40 ° C for 2-4 months And 10 to 30 parts by weight of the fermented product.

The present invention also relates to

(a) ginseng; Angelica; Preparing a mixture which is prepared by finely dividing and washing the lateral and lateral leaves or spruce, and mixing the mixture at a weight ratio of 1: 3: 1 to 3: 1 to 3;

(b) hot water extraction from 500 to 1,000 parts by weight of water at 80 to 100 DEG C for 0.5 to 5 hours based on 100 parts by weight of the mixture;

(c) concentrating the hot-water extract prepared in the step (b) to 250 to 500 parts by weight based on 100 parts by weight of the mixture of step (a), and extracting ginseng, Angelica gigas, Producing;

(d) 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 in dry salted, To 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3;

(e) 5 to 20 parts by weight of saccharide and 80 to 200 parts by weight of water are added to a fermentation tank based on 100 parts by weight of the mixture of step (d), and at least one strain of lactic acid bacteria and yeast is inoculated, Fermenting for 4 months to prepare a fermented product; And

(f) ginseng produced in step (c); Angelica; And 30 to 70% by weight of the extracts of P. japonicus or P. japonicus and 30 to 70% by weight of the fermented product prepared in the step (e).

The method for producing the composition for preventing hair loss and promoting hair growth comprises

(g) finely chopping rice hull, husk, buckwheat husks, and peeled dried soybeans to prepare a mixture in a weight ratio of 1: 3: 1 to 3: 1 to 3: 1 to 3;

(h) adding 300 to 700 parts by weight of water based on 100 parts by weight of the mixture, followed by hot water extraction at 80 to 100 ° C for 0.5 to 5 hours;

(i) concentrating the hot-water extract to 150-300 parts by weight based on 100 parts by weight of the mixture of step (g);

(j) a concentrate of step (i) and 5 to 20 parts by weight of a sugar source are placed in a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast, and fermented at 20 to 40 DEG C for 2 to 4 months to produce rice husks, , And a peeled dried soybean fermented product; And

(k) 10 to 30 parts by weight of the fermented product prepared in the step (j) is further added to 100 parts by weight of the composition for promoting hair loss prevention and hair growth, which is prepared in the step (f) have.

The hair loss preventing and hair growth promoting composition of the present invention is composed of natural ingredients and provides excellent hair loss prevention and hair growth promoting effect without any concern about side effects such as finasteride and minoxidil.

Also, it is easy to use as a dermal type.

The method for producing a composition for preventing hair loss and promoting hair growth of the present invention provides a method for preparing a composition for preventing hair loss and promoting hair growth in a very simple and effective manner.

1 to 4 are photographs showing the effect of the composition for preventing hair loss and hair growth of the present invention before use and after 3 months of use.

Hereinafter, the present invention will be described in detail.

Ginseng; Angelica; Wherein the mixture is prepared by mixing 500-1,000 parts by weight of water based on 100 parts by weight of the mixture, and adding the extracted hot-water extract to 200-500 weight parts 30 to 70% by weight of a concentrate concentrated in part; And

3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: And 30 to 70% by weight of a fermented product fermented at 20 to 40 DEG C for 2 to 4 months. The present invention also relates to a composition for promoting hair loss prevention and hair growth.

The composition for preventing hair loss and for promoting hair growth comprises 100 parts by weight of the composition

300 to 700 parts by weight of water are added to 100 parts by weight of the mixture, and the mixture is heated to a temperature of 1 to 3: 1 to 3: 1 to 3: 1 to 3, The concentrate obtained by concentrating the extracted hot-water extract to 150-300 parts by weight and the sugar source 5-20 parts by weight are put into a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast and fermented at 20-40 ° C for 2-4 months And 10 to 30 parts by weight of the fermented product.

As described above, when the fermented product obtained by fermenting the extract of the husks of rice husk, husk, buckwheat husk, and husked dried pea husk is further contained, it exhibits a better effect of preventing hair loss and promoting hair growth.

Hereinafter, the components of the composition for preventing hair loss and promoting hair growth will be described in detail.

The ginseng has been known to be effective for skin aging, recovery of damaged skin caused by oxidative stress, moisturizing, scalp, and the like.

The Angelica gangrene is the main medicinal substance which plays a role of producing the warmth, warmth, nontoxic, and producing blood of the Angelica gigas. Most of the diseases are almost unrelated to blood, Is a very important medicinal drug. In addition to the above-mentioned blood-circulating and hysteretic actions, anti-cancer effects and hypotensive effects have also been reported.

The mesophyll or spruce tree has a Myricetin component and an antimicrobial hinokitiol component that play an important role in hair growth. And since the leaves of the leaves and the leaves of the leaves or the trees are so hot, they eat lots of spicy, hot and fatty foods, and treat hair loss caused by overeating, which makes the hair black and hairy.

Orostachys japonicus A. Berger is a perennial herbaceous plant with a crassacea called Iwamatsu and Okso (松松). It is used for the fever, swelling, hemostasis, It is widely used for cancer treatment by therapy. It is a fleshy perennial herb that grows on the side of a rock, but has a characteristic of blossoming and fruiting when it blooms.

The above Morinda officinalis is said to be Indian mulberry in India, Vagitian in China, analgesic tree in Caribbean, cheese fruit in Australia and Nono in Tahiti. It is said to be a sea pirate or a paradise. Its height is 3 ~ 12m and its size varies. Leaves are egg-shaped, 30cm long and 15cm wide. Flowers are small and white, come out from the axilla of the leaves and bloom from summer to autumn many times. The fruit is about 10cm in size and looks like a potato, the surface is rugged, and there are marks on the surface. The fruit contains a lot of fiber and juice, especially when the fruit is ripe, the yellowish-white skin becomes thin and appears to be transparent. At this time, the fruit, which could not feel the taste, gave an unpleasant taste and smelled badly like rotten cheese. The fruit can be seen almost year-round and contains a lot of brown seeds. Leaves, stems, flowers, fruits and seeds have been used in folk remedies and are listed as the best natural remedies according to ancient literature in the South Pacific. In fact, it contains anthraquinone and serotonin, which helps digestion, reduces pain, and works on hypertension and cancer.

The above-mentioned Porphyrae extract means obtained by extracting various organs or parts such as leaves, flowers, fruits, stems, roots, branches and bark, etc., preferably obtained by extracting roots of Phragmites.

The above-mentioned Hassuo is a high-medicinal herb that has been renowned as a nourishing medicine for a long time. It strengthens the kidney function and strengthens the tincture, darkens the hair, makes it live longer without the disease, and improves the function of the liver to eliminate fatigue, It strengthens the muscles and strengthens the heart. It is also effective for the nervous breakdown and insomnia. It is excellent for hematopoiesis and it is good for the treatment of anemia. It is widely used for women's physiological impurity, uterine inflammation and chronic constipation.

The herbaceous plant is cultivated as a medicinal plant in the perennial herbaceous plant of the family Mythaceae. It has the blood circulation promotion, cleanses the blood and has a gentle nature. It has chemical components such as amino acids and essential oils (Ligustlide, Butylidenphthalide, Butyipharhalide, Neocnidilide, Cnideilide, Sedanolide and Senkyunolide) And the like.

It is a perennial plant, with anemone and tannin in its roots. Fresh roots contain protoanomonin in the form of two molecules in the air to become anemonin. Pulsatilla koreana (Pulsatilla koreana) is a perennial herb that grows about 40cm in height, and grows in mountainous, dry dogs. The flowers bloom in April-May with red purple, the fruit is covered with white fur, and it is used for headache, edema, dysentery, heart disease, schizophrenia and gastritis. It is known that there is a mystifying effect in treating brain diseases in particular. It is possible to fix various kinds of cancer including brain tumor by using lawful roots well.

The above-mentioned Tremella fuciformis grows in various hardwood dead trees or branches in summer and autumn. Fruiting body is 3 ~ 8cm in diameter, 2 ~ 5cm in height, lumpy shape with irregular wave shape. The surface is pure white, smooth, and the fascial layer develops throughout the surface. The tissue is translucent gelatinous. It is medicinal mushroom which has immunity enhancement, cholesterol lowering, blood sugar lowering, antioxidant effect by edible mushroom, and it is known that it is helpful in various diseases such as respiratory diseases, gastritis, hypertension and menstrual irregularity. The main components include vitamins B1, B2, D and niacin, mannitol, glycerol, glucose, trehalose, hemicellulose, chitin, pectin, (pectin), luconoxylomannan, lignin, and the like are known.

The mugwort is a perennial herb belonging to the Ungeraceae family, and is obtained by picking up about 60-90 cm tall and drying it in shade. Mugwort 's weakness is effective for various customs, tumor, etc. It is known to have a certain dermatological disease, good for scalp health and nutritional supply, good scalp blood circulation, and preventing hair loss.

The green tea has been known to be a panacea since it was first introduced, and has a variety of beneficial ingredients from health, and has various effects ranging from prevention of adult diseases such as hypertension and diabetes to diet. In particular, tannic acid, flavonoids, and catechin components of green tea leaves can effectively work against seborrheic dandruff and hair loss.

If we look at the old records of our ancestors, we can see that there is no disease throughout the year when bathing with hair in Changpo-tang, It has been reported that the action against sedation, analgesic action, anticonvulsant action and circulatory system, action against chinaxheae, action against digestive system, action on skin, and especially alcohol extract can be used as insecticide and insecticide have.

The gujie has a physiological activity such as hair loss prevention, aging prevention, detoxification, strengthening of cell replication, capillary strengthening, antioxidant activity, reduction of blood cholesterol, and collagen synthesis by decreasing DHT content by decreasing the DHT content have. In one room, it is used as a tonic or antipyretic. In addition, it improves vision, prevents adult diseases such as diabetes, improves lung and kidney function, and mixes with perilla oil to mature and prevent hair from becoming gray when applied to the head. Bacillus, beacaxanthin, carotene, thiamin, vitamin A, B1, B2, C, etc., which are components of hematopoietic action, cholesterol lowering action, anti-hepatic action, blood pressure lowering, blood glucose lowering, growth promotion, . The efficacy of goji berries gugija chronic hepatitis, liver cirrhosis, tonic, antipyretic is used for back pain in the back. Gugija root bark is called gigokpi (头骨皮) is used as an antipyretic agent such as zoogal and chill in one room. In the "Divine Husbandman's Classic of Maternity", written in 1800 years ago, there are ginseng and gugi, which is called "上 药". In the "baseball cap", it has been introduced that when taken for a long time, the muscles become hard and the body becomes light, so that it does not get old and does not catch heat and cold. In the private sector, it is used as a motorcycle

Akebiae quinata Decne is a deciduous vine plant belonging to the genus Lepidoptera, and grows throughout the country. In one tree, female flowers and male flowers are used separately for different ornamental purposes. In addition, young leaves and fruit are used for edible, root and branch medicinal purposes. Specifically, the sprouts and young stems were eaten as herbs, and the flowers were dried and used instead of perfume. Stem boiled water was used as a yellow or yellowish dye, and was especially important for medicinal use because it has efficacy for anti-inflammatory diuretics, urinalysis, urethritis, sore throat, and psychotropic drugs. Roots and bark are effective for urination disorders, and fruits are effective for diuretics, paralysis, and arthritis.

The rice hull, hull, buckwheat husk and husk dried with husk are often used as grains or fruit husks, but they are not widely used as active ingredients. However, according to research conducted by the inventors of the present invention, they provide excellent effects for preventing hair loss and promoting hair growth .

The rice husk contains 35 to 46% of crude fiber, 22 to 5% of soluble saccharide, 13 to 21% of ash, and 2 to 3% of crude protein. Almost 90% of the ash from the rice husk is silicon and contains a lot of potassium, calcium and magnesium.

It is known that the urine is useful for improving digestion and preventing skin aging.

The buckwheat husk helps smooth blood flow and diuretic action, cleanses the blood, so it smoothes blood vessels and stabilizes blood pressure.

The above-mentioned peeled dried soybeans are said to protect the intestines and stomachs in the main stem of the main river, warm the genus, enhance the kidney function, protect the epidermis and are effective for inflammatory diseases such as boils and hemorrhoids. It is known that soybean is excellent for respiratory diseases such as rhinitis, allergic rhinitis, cold, sinusitis, runny nose, sneezing, nasal obstruction and asthma. In addition, it can stimulate growth and strengthens bones, so it helps to grow children. It is effective against skin diseases because of atopy, acne and skin moisturizing effect. It removes wastes and helps constipation and obesity, And it is good for symptom such as sloppy call. In addition, it is excellent for inflammation of liver and boil, and is good for oral mucositis, etc. It is known that it promotes blood circulation, strengthens immunity, excretes toxins in the body and detoxifies.

In addition,

(a) ginseng; Angelica; Preparing a mixture which is prepared by finely dividing and washing the lateral and lateral leaves or spruce, and mixing the mixture at a weight ratio of 1: 3: 1 to 3: 1 to 3;

(b) hot water extraction from 500 to 1,000 parts by weight of water at 80 to 100 DEG C for 0.5 to 5 hours based on 100 parts by weight of the mixture;

(c) concentrating the hot water extract prepared in step (b) to 250 to 500 parts by weight based on 100 parts by weight of the mixture of step (a). Angelica; And extracting a lateral leaf or periwinkle extract;

(d) 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 in dry salted, To 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3;

(e) 5 to 20 parts by weight of saccharide and 80 to 200 parts by weight of water are added to a fermentation tank based on 100 parts by weight of the mixture of step (d), and at least one strain of lactic acid bacteria and yeast is inoculated, Fermenting for 4 months to prepare a fermented product; And

(f) ginseng produced in step (c); Angelica; And 30 to 70% by weight of the extracts of P. japonicus or P. japonicus, and 30 to 70% by weight of the fermented product prepared in the step (e); and a process for preparing the composition for promoting hair loss prevention and hair growth.

The production method of the present invention

(g) finely chopping rice hull, husk, buckwheat husks, and peeled dried soybeans to prepare a mixture in a weight ratio of 1: 3: 1 to 3: 1 to 3: 1 to 3;

(h) adding 300 to 700 parts by weight of water based on 100 parts by weight of the mixture, followed by hot water extraction at 80 to 100 ° C for 0.5 to 5 hours;

(i) concentrating the hot-water extract to 150-300 parts by weight based on 100 parts by weight of the mixture of step (g);

(j) a concentrate of step (i) and 5 to 20 parts by weight of a sugar source are placed in a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast, and fermented at 20 to 40 DEG C for 2 to 4 months to produce rice husks, , And a peeled dried soybean fermented product; And

(k) 10 to 30 parts by weight of the fermented product prepared in step (j) is further added to 100 parts by weight of the composition for promoting hair loss prevention and hair growth, which is prepared in step (f) .

The source is a feed for the strain, and any of those known in the art may be used without limitation. For example, sugar, starch syrup, oligo fructose and the like can be mentioned, and other sugars can be used without limitation.

The lactic acid bacteria usable in the present invention can be selected from the group consisting of Lactobacillus sp., Streptococcus sp., Pediococcus sp., Leuconostoc sp. ), Bifidobacterium sp., And the like.

Examples of the yeast include Saccharomyces sereviciae, Saccharomyces rouxii, Saccharomyces oviformis, Saccharomyces steineri, Saccharomyces cerevisiae, ) May be used.

Since the composition according to the present invention is directly applied to a human body in the form of an external preparation for skin or the like, the kind of the lactic acid bacteria or yeast is selected in consideration of human stability and fermentation ability. A strain or a yeast can also be used, and the present invention is not limited to the kind of the lactic acid bacteria and the yeast.

Since the compositions for preventing hair loss and promoting hair growth of the present invention and the respective methods described in the method for producing hair loss can be commonly applied, the overlapping contents are omitted.

The hair loss preventing and hair growth promoting composition of the present invention can be used in cosmetics such as shampoo, rinse and tonic, or in pharmaceuticals or quasi drugs.

The compositions of the present invention may further comprise a pharmaceutically or cosmetically acceptable carrier and may be in the form of a cream, lotion, tonic, spray, aerosol, oil, solution, suspension, gel, ointment, emulsion, Can be produced in a pulsatile form. The composition of the present invention contains a conventional base, and if necessary, other ingredients generally used as medicines or cosmetic raw materials can be suitably blended.

The base of the composition of the present invention can be any of those conventionally used, and examples thereof include purified water, mineral water, ethanol, glycerin, squalene, 1,3-propylene glycol, 1,3- Oil and liquid petrolatum. Examples of other ingredients to be incorporated into the composition of the present invention include, but are not limited to, surfactants, emulsifiers, thickeners, preservatives (e.g., p-hydroxybenzoate), antioxidants, fragrances and the like.

The composition of the present invention may contain, in addition to the above-mentioned components, a component capable of supplying ultrafiltration to hair follicles or a hair growth promoting auxiliary component that is commonly used. Examples thereof include vitamins, amino acids, But are not limited to these. The amount thereof is preferably 0.0001 to 10% by weight, preferably 0.01 to 1% by weight of the total composition. The vitamins include, but are not limited to, vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, and biotin H (vitamin H) The term includes, but is not limited to, waveguide. In addition, animal and plant oils include, but are not limited to, maize oil, flax oil, olive oil, camellia oil, rapeseed oil, sesame oil, and embryo oil.

The composition of the present invention can be used by a method of directly applying or dispersing the hair or scalp. In the present invention, 'hair' includes hair follicles and hair follicles, hair and eyelashes and eyelashes, mustache, armpits, pubic hair, hair follicles and hair follicles. Accordingly, the present invention provides a hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack, hair treatment, eyebrow hair removal agent, Shampoos and pet rinse.

The dose of the composition according to the present invention should be appropriately determined in consideration of sex, age, hair loss symptom, hair condition, and the like. Preferably from 1 to 5 times per day for adults, based on an adult extract of 3 to 15 cc.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Production Example 1: Ginseng; Angelica; Manufacture of extracts of papaya leaves

200 g of ginseng; Angelica gigas 200g; ≪ / RTI > and 200 grams of papaya or deciduous trees were cut and washed. The washed ginseng; Angelica; And 4 liters of water were added to the papillae or spruce trees and extracted for 3 hours at a temperature of 100 ° C., filtered through a 250-mesh filter cloth (NBC inc. 38T05221-06), concentrated using a vacuum condenser, Angelica; And 1.6 kg of P. japonicus or P. japonicus extract.

Manufacturing example  2: Welcome , A strange river , Sewage , Celestial palm, White throat mushroom , Wormwood, green tea, Iris , And property Fermentation product  Produce

100 g each of dried dried persimmon, sea urchin, mackerel, mulberry, white mushroom, mugwort, green tea, iris, ginger, and corn were washed to remove impurities. The water was removed and put into a fermenter, and 200 g of brown sugar and 1 liter of water Respectively. Streptococcus sp. The strain was inoculated and fermented at 25 캜 for 3 months to prepare a fermented product.

Manufacturing example  3: chaff, Julie , Buckwheat husks and A small snack Fermentation product  Produce

After removing impurities by washing with water, 5 liters of water was added to the boiling water, and the mixture was extracted at a temperature of 100 for 3 hours. Then, the 250 mesh filter plug (NBC inc. 38T05221 -06) to prepare 2 liters of an extract. The extract solution was put into a fermenter, 200 g of brown sugar was added, and Streptococcus sp. The strain was inoculated and fermented at 25 캜 for 3 months to produce rice hull, hull, buckwheat husk and soybean fermented product.

Example  1: Preparation of compositions for preventing hair loss and promoting hair growth

Ginseng prepared in Preparation Example 1; Angelica; And 500 g of the extracts of Paeonia japonica L. or P. japonicus, 500 g of the fermented product prepared in Preparation Example 2, and 200 g of ethanol were mixed to prepare a composition for preventing hair loss and promoting hair growth.

Example  2: Preparation of compositions for preventing hair loss and promoting hair growth

Ginseng prepared in Preparation Example 1; Angelica; 400 g of the extract of P. japonicus or P. japonicus, 400 g of the fermentation product prepared in Preparation Example 2, 200 g of the rice husk, hull, buckwheat husk and soybean fermented product prepared in Preparation Example 3, and 200 g of ethanol were mixed to prevent hair loss and A composition for promoting hair growth was prepared.

Experimental Example  1: Confirmation of effect of composition for prevention of hair loss and promotion of hair growth

Eight male and eight female subjects each having hair loss and bald hair tonic (JWBIO company JW12 hair tonic), which were purchased from commercially available hair loss prevention and hair growth promoting composition prepared according to Examples 1 and 2, respectively, Month, morning, and evening, respectively. The results are shown in Table 1 below.

Subject 1 month 2 months 3 months Side Effect Example 1
Composition for preventing hair loss and promoting hair growth A thirties man + ++ ++ none Thirties woman - + ++ none A man in his forties + ++ ++ none A woman in his forties + ++ +++ none A man in his 50's - ++ ++ none A fifties woman + + ++ none A man in his 60s + ++ +++ none A woman in her 60s - + ++ none Example 2
Composition for preventing hair loss and promoting hair growth A thirties man + ++ +++ none Thirties woman + ++ +++ none A man in his forties + + ++ none A woman in his forties + ++ ++ none A man in his 50's + ++ +++ none A fifties woman + ++ +++ none A man in his 60s - + ++ none A woman in her 60s + ++ +++ none On the market
Hair loss prevention and hair growth
Hair tonic A thirties man - ++ ++ none Thirties woman - - + none A man in his forties - + + none A woman in his forties - + ++ none A man in his 50's - + + Itching of skin A fifties woman - ++ ++ none A man in his 60s - + + none A woman in her 60s - + ++ none

week)

-: no effect

+: Slight improvement (hair loss is improved)

++: The improvement effect is pronounced (hair loss is improved and hair growth is slightly improved)

+++: Excellent improvement effect (hair loss is improved and hair growth is remarkably improved)

As shown in Table 1, the hair loss prevention and hair growth promoting compositions of Examples 1 and 2 of the present invention were found to have superior hair loss prevention and hair growth promoting effects as compared with the hair tonics purchased in the market 4).

In particular, the hair loss prevention and hair growth promoting composition of Example 2, which further contained rice hull, hull, buckwheat husk and soybean fermented product, showed remarkably superior effects to other compositions in preventing hair loss and promoting hair growth.

Experimental Example  2: Confirmation of the safety of the composition for prevention of hair loss and promotion of hair growth

In order to confirm the safety of the hair loss prevention and hair growth promoting composition of the present invention, a human body application test was commissioned by the Korean Society of Dermatological Science, and the following results were obtained.

(1) Products for testing

1) Hair vaccine scalp essence

The safety of the hair loss prevention and hair growth promoting composition prepared in Example 1 was confirmed.

2) LOYA Hair Tonic

A hair tonic was prepared by the following composition and its safety was confirmed.

ingredient content Resorcinol 0.1% menthol 0.05% Panthenol 0.2% Salicylic acid 0.1% Tocopheryl acetate 0.1% Pyridoxine hydrochloride 0.1% Castor oil 5.0% The composition prepared in Example 1 50.0% Pigment 0.3% Spices 0.3% ethanol 10.0% Purified water Balance Sum 100%

3) Manufacture of a part of eyebrow eyebrows

The following composition was used to make the hair on the eyebrows of hair vaccines to confirm safety.

ingredient content Resorcinol 0.1% menthol 0.05% Panthenol 0.2% Salicylic acid 0.1% Tocopheryl acetate 0.1% Pyridoxine hydrochloride 0.1% Castor oil 5.0% The composition prepared in Example 1 50.0% Pigment 0.0% Spices 0.3% ethanol 5.0% Purified water Balance Sum 100%

(2) Subject  Basic Information

The information of the subjects who participated in this test is as follows.

Basic information of the subject Registered subject 35 people Final Completion Tester 35 people gender Men and women Average age 41.46 years Standard Deviation 10.76

(3) In skin patch test  Safety evaluation result by

The results of the skin patch test of 35 subjects were shown in Table 5 below.

In test substance # 1, no ± stimulation was observed after 4 hours, ± 2 hours after 24 hours, and no stimulation after 48 hours. The mean skin response was 0.95, which was judged to be unstable according to the criteria.

In test substance # 2, no ± stimulation was observed after 4 hours, ± 3 hours after 24 hours, and no stimulation after 48 hours. The mean skin response was 1.11, which was judged to be unstimulated according to the criteria.

In test substance # 3, no ± stimulation was observed after 4 hours, ± 3 hours after 24 hours, and no stimulation after 48 hours. The mean skin response was 1.11, which was judged to be unstimulated according to the criteria.

Claims (4)

Ginseng; Angelica; Wherein the mixture is prepared by mixing 500-1,000 parts by weight of water based on 100 parts by weight of the mixture, and adding the extracted hot-water extract to 200-500 weight parts 30 to 70% by weight of a concentrate concentrated in part; And
3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: And 30 to 70% by weight of a fermented product obtained by inoculating the strain at 20 to 40 DEG C for 2 to 4 months. The method according to claim 1,
100 parts by weight of the composition for preventing hair loss and promoting hair growth
300 to 700 parts by weight of water are added to 100 parts by weight of the mixture, and the mixture is heated to a temperature of 1 to 3: 1 to 3: 1 to 3: 1 to 3, The concentrate obtained by concentrating the extracted hot-water extract to 150-300 parts by weight and the sugar source 5-20 parts by weight are put into a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast and fermented at 20-40 ° C for 2-4 months And 10 to 30 parts by weight of the fermented product. (a) ginseng; Angelica; Preparing a mixture which is prepared by finely dividing and washing the lateral and lateral leaves or spruce, and mixing the mixture at a weight ratio of 1: 3: 1 to 3: 1 to 3;
(b) hot water extraction from 500 to 1,000 parts by weight of water at 80 to 100 DEG C for 0.5 to 5 hours based on 100 parts by weight of the mixture;
(c) concentrating the hot water extract prepared in step (b) to 250 to 500 parts by weight based on 100 parts by weight of the mixture of step (a). Angelica; And extracting a lateral leaf or periwinkle extract;
(d) 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 in dry salted, To 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3;
(e) 5 to 20 parts by weight of saccharide and 80 to 200 parts by weight of water are added to a fermentation tank based on 100 parts by weight of the mixture of step (d), and at least one strain of lactic acid bacteria and yeast is inoculated, Fermenting for 4 months to prepare a fermented product; And
(f) ginseng produced in step (c); Angelica; And 30 to 70% by weight of the extracts of P. japonicus or P. japonicus and 30 to 70% by weight of the fermented product prepared in the step (e). The method of claim 3,
(g) finely chopping rice hull, husk, buckwheat husks, and peeled dried soybeans to prepare a mixture in a weight ratio of 1: 3: 1 to 3: 1 to 3: 1 to 3;
(h) adding 300 to 700 parts by weight of water based on 100 parts by weight of the mixture, followed by hot water extraction at 80 to 100 ° C for 0.5 to 5 hours;
(i) concentrating the hot-water extract to 150-300 parts by weight based on 100 parts by weight of the mixture of step (g);
(j) a concentrate of step (i) and 5 to 20 parts by weight of a sugar source are placed in a fermentation tank and inoculated with one or more strains of lactic acid bacteria and yeast, and fermented at 20 to 40 DEG C for 2 to 4 months to produce rice husks, , And a peeled dried soybean fermented product; And
(k) 10 to 30 parts by weight of the fermented product prepared in step (j) is further added to 100 parts by weight of the composition for promoting hair loss prevention and hair growth, which is prepared in step (f) The method of claim 1,

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