KR102585336B1 - Medicinal herbs fermentation product for prevention, improvement or protection hair loss and use thereof - Google Patents

Abstract

The present invention relates to fermented herbal medicines for preventing, improving or preventing hair loss and their uses. The fermented products of the present invention include black soybean, sophora ginseng, green tea, goji berry, hawthorn, astragalus, chrysanthemum chrysanthemum, sangji, cypress, angelica root, astragalus, and black sesame. Extracts of herbal medicines, including nasturtium, Geumjeoncho, Houttuynia cordata, arborvitae, columbine leaves, moringa, perilla leaves, mugwort, columbine leaves, chinensis bark, calendula, graviola, rosemary, and laurel, are fermented with brewer's yeast ( Saccaromyces Spp.) Accordingly, it has the advantage of being excellent in preventing hair loss and promoting hair growth. In addition, it is very safe for the human body as it uses environmentally friendly natural materials as its main raw material.

Description

{Medicinal herbs fermentation product for prevention, improvement or protection hair loss and use thereof}

The present invention relates to fermented herbal medicine for preventing, improving or preventing hair loss and its use.

Hair protects the head from sunlight, cold, and external shocks, and is also important from a cosmetic perspective. It is known that about 50 to 100 hairs of a normal person naturally fall out per day. On the other hand, hair loss is a condition in which more hair than the normal number of hairs falls out due to various causes.

Alopecia patients suffer significantly socially, mentally, and psychologically due to changes in their image due to hair loss, and as interest in beauty increases along with economic improvement, the desire to recover from hair loss is increasing.

The causes of hair loss known to date are excessive sebum production due to circulatory system abnormalities such as abnormalities in the internal branch system and blood circulation disorders, nutritional deficiencies in the hair roots, physical factors such as allergies and bacterial infections, hormonal or genetic factors such as the influence of male hormones, and various types of pollution. It is presumed that it occurs due to a complex effect of environmental factors such as the use of processed foods, shampoos, soaps, mousses, hair gels, hair sprays, perms, dyeing, and hair dryers, mental and social factors due to excessive stress, and aging.

If hair loss occurs due to the above factors, recovery is possible through surgical operations such as scalp plastic surgery and autologous hair transplantation, but the surgery has the disadvantage of being a very large psychological and financial burden on the patient.

Of course, there are ways to improve hair loss by internally applying or orally administering commercially available drugs, but there are many problems such as causing serious side effects on the human body. Among them, Minoxidil is a commonly used topical drug that has been approved by the U.S. FDA. It is effective in preventing hair loss by inducing capillaries, but it requires frequent use and is only effective during drug use. The effect is temporary, and side effects such as itching and scalp irritation may occur.

Therefore, there is an urgent need to develop a new hair loss prevention composition made of safe natural materials while increasing the skin or cell penetration of useful substances into the scalp and hair roots.

Korean Patent No. 10-0780180 (November 21, 2007) discloses an herbal composition for preventing hair loss and promoting hair growth and a method for producing the same. Korean Patent No. 10-1443182 (2014.09.16) discloses a complex extract of an herbal medicine with anti-hair loss and hair growth-promoting effects, a manufacturing method thereof, and a cosmetic composition for hair growth using the same.

The purpose of the present invention is to provide fermented herbal medicine for preventing, improving or preventing hair loss and its use.

The present invention is based on the total weight of herbal medicine, 5 to 10 parts by weight of black beans, 4 to 9 parts by weight of sophora ginseng, 3 to 7 parts by weight of green tea, 3 to 7 parts by weight of goji berry, 3 to 7 parts by weight of hawthorn, and 2 to 6 parts by weight of astragalus. , Chrysanthemum 2-4 parts by weight, Sangji 2-4 parts by weight, Cypress 2-4 parts, Angelica 2-4 parts by weight, Seokchangpo 2-4 parts by weight, Black Sesame 2-4 parts by weight, Nasturtium herb 2-4 parts by weight , 2-4 parts by weight of Geumjeoncho, 2-4 parts by weight of Houttuynia cordata, 2-4 parts by weight of Cupressa, 2-4 parts by weight of Goji leaves, 2-4 parts by weight of Moringa, 2-4 parts by weight of perilla leaves, 2-4 parts by mugwort. Herbal medicine containing 4 parts by weight, 2 to 4 parts by weight of leaf, 2 to 4 parts by weight of Morus bark, 2 to 4 parts by weight of calendula, 0.5 to 1.5 part by weight of graviola, 0.5 to 1.5 part by weight of rosemary, and 0.5 to 1.5 part by weight of laurel. Step (a) of adding water to the mixture and performing low-temperature extraction at 0 to 4°C to obtain a primary herbal medicine extract; After step (a), the extract is filtered and water is added to the remaining herbal medicine mixture, followed by high-temperature extraction at 80 to 100°C to obtain a secondary herbal medicine extract (b); Step (c) of mixing the primary herbal medicine extract obtained in step (a) and the secondary herbal medicine extract obtained in step (b), inoculating brewer's yeast ( Saccharomyces spp.), and performing primary fermentation; It provides a method for producing a fermented extract for preventing, improving or preventing hair loss, which is characterized in that it is manufactured comprising:

At this time, the primary fermentation in step (c) is preferably performed at 15 to 23°C for 2 to 5 days.

In addition, the method for producing a fermented extract for preventing, improving or preventing hair loss of the present invention is preferably inoculated with brewer's yeast ( Saccharomyces spp.) after the primary fermentation in step (c) and incubated at 25 to 30 ° C. for 1 ~ It is better to further include step (d) of performing secondary fermentation for 3 days.

Meanwhile, the present invention provides a cosmetic composition containing a fermented extract for preventing, improving or preventing hair loss prepared by the method described above.

At this time, the cosmetic composition is for preventing, improving or preventing hair loss.

The fermented product of the present invention includes black beans, sophora ginseng, green tea, goji berry, sorghum, astragalus, chrysanthemum chrysanthemum, sorrel, cypress, angelica root, iris, black sesame, nasturtium, geumjeoncho, Houttuynia cordata, arborvitae, columbine leaves, moringa, perilla leaves, By fermenting the extracts of herbal medicines, including mugwort, leafy greens, linden bark, calendula, graviola, rosemary, and laurel, with brewer's yeast ( Saccaromyces Spp.), it has the advantage of preventing hair loss and promoting hair growth. In addition, it is very safe for the human body as it uses environmentally friendly natural materials as its main raw material.

Figure 1 shows the results of comparing the effects of preventing hair loss and promoting hair growth in a female tester after applying the fermented herbal medicine shampoo according to the present invention for 1 month.
Figure 2 shows the results of comparing the hair loss prevention and hair growth promotion effects of a male tester after applying the fermented herbal medicine shampoo according to the present invention for 1 month.

The present invention is based on the total weight of herbal medicine, 5 to 10 parts by weight of black beans, 4 to 9 parts by weight of sophora ginseng, 3 to 7 parts by weight of green tea, 3 to 7 parts by weight of goji berry, 3 to 7 parts by weight of hawthorn, and 2 to 6 parts by weight of astragalus. , Chrysanthemum 2-4 parts by weight, Sangji 2-4 parts by weight, Cypress 2-4 parts, Angelica 2-4 parts by weight, Seokchangpo 2-4 parts by weight, Black Sesame 2-4 parts by weight, Nasturtium herb 2-4 parts by weight , 2-4 parts by weight of Geumjeoncho, 2-4 parts by weight of Houttuynia cordata, 2-4 parts by weight of Cupressa, 2-4 parts by weight of Goji leaves, 2-4 parts by weight of Moringa, 2-4 parts by weight of perilla leaves, 2-4 parts by mugwort. Herbal medicine containing 4 parts by weight, 2 to 4 parts by weight of leaf, 2 to 4 parts by weight of Morus bark, 2 to 4 parts by weight of calendula, 0.5 to 1.5 part by weight of graviola, 0.5 to 1.5 part by weight of rosemary, and 0.5 to 1.5 part by weight of laurel. Step (a) of adding water to the mixture and performing low-temperature extraction at 0 to 4°C to obtain a primary herbal medicine extract; After step (a), the extract is filtered and water is added to the remaining herbal medicine mixture, followed by high-temperature extraction at 80 to 100°C to obtain a secondary herbal medicine extract (b); Step (c) of mixing the primary herbal medicine extract obtained in step (a) and the secondary herbal medicine extract obtained in step (b), inoculating brewer's yeast ( Saccharomyces spp.), and performing primary fermentation; It provides a method for producing a fermented extract for preventing, improving or preventing hair loss, which is characterized in that it is manufactured comprising:

At this time, the herbal medicine in step (a) can preferably be cut into pieces of less than 5 cm in width or diameter and used in the extraction process.

At this time, the water in step (a) or step (b) is preferably added at 10 to 15 times the weight of the herbal medicine 566.

In the present invention, extraction is divided into two stages, low-temperature extraction and high-temperature extraction, and is carried out sequentially. Through low-temperature extraction, ingredients that are easily destroyed at high temperatures can be extracted in their intact form. And by extracting once more through high-temperature extraction, surplus useful substances can be further extracted.

Meanwhile, in the present invention, the primary herbal medicine extract obtained in step (a) and the secondary herbal medicine extract obtained in step (b) can be concentrated and mixed and then used as a medium, or after mixing first, The concentrated product can be used as a medium. Additionally, if necessary, purified water can be added or ingredients necessary for the growth of beer yeast can be added.

In the present invention, brewer's yeast can preferably be inoculated separately into primary and secondary fermentation. At this time, more preferably, in the primary fermentation, strains at a weight ratio of 10 to 15 based on 100 weight of the herbal medicine extract may be added, and in secondary fermentation, strains at a weight ratio of 1 to 5 based on 100 weight of the herbal medicine extract may be added.

At this time, the primary fermentation in step (c) is preferably performed at 15 to 23°C for 2 to 5 days. Under the primary fermentation conditions according to the present invention, the yeast's ability to decompose sugar becomes stronger, and it grows by focusing only on the decomposition of sugar.

In addition, the method for producing a fermented extract for preventing, improving or preventing hair loss of the present invention is preferably inoculated with brewer's yeast ( Saccharomyces spp.) after the primary fermentation in step (c) and incubated at 25 to 30°C for 1 to 3 hours. It is better to further include step (d) of performing secondary fermentation for one day. The yeast grown in the primary fermentation process becomes metabolically active through the secondary fermentation according to the present invention, producing high molecular substrates into low molecular metabolites. By performing this fermentation in step (d), the efficacy of preventing or improving hair loss can be further increased.

At this time, after fermentation in step (d), filtration may be further performed.

Meanwhile, the extraction material used in the present invention is explained as follows.

Black beans are also called black soybeans. It does not refer to one specific type of soybean, but refers to all black-colored soybeans. Heuktae, Seoritae, Seomoktae (Yeodu), etc. belong to black beans. Compared to regular beans, black beans have a similar nutrient content, but they contain four times more anti-aging ingredients and are known to be effective in preventing adult diseases and dieting, so they are in the spotlight as a health food. In 《Herbal Medicine》, the efficacy of black beans is recorded as "controlling the kidneys, eliminating edema, activating blood circulation, and removing the poison of all medicines."

Sophora ginseng contains matrine as a medicinal ingredient, and its antipyretic and diuretic effects were recognized in animal tests. It has a healing effect on the stomach, so gastroenteritis, enteritis, and bacterial dysentery can be cured when taken in a decoction with cedar or licorice. It is also effective for skin purulence and eczema, and when a woman has severe itching in the vulva, it is treated by making a decoction and washing the affected area. For skin tinea fungus, make an ointment by mixing it with black pepper and apply it to the affected area to treat it.

Green tea is a tea made from unfermented tea leaves. Drinking tea frequently has the effect of preventing the formation of blood clots and lowering cholesterol and blood sugar levels. Green tea's attractive bitter taste is due to a tannin component called catechin. A cup of green tea contains approximately 100 mg of catechin, a type of polyphenol with antioxidant properties, and the most powerful ingredient, 'EGCG', is known to have an antioxidant effect 20 times higher than vitamin C. Catechin is known to have anti-cancer effects and functions to protect blood vessel health. Catechin has the effect of preventing stomach cancer and lung cancer, lowers blood pressure, and increases blood flow to the heart. It inhibits the absorption of cholesterol within the digestive tract and suppresses the deposition of lipids in the body. This lowers blood pressure, strengthens the heart, and prevents fatty liver disease and arteriosclerosis. It also inhibits the activity of cold viruses and prevents body cells from being infected by viruses.

Goji berry is considered one of the three best medicines along with ginseng and ginseng. It is rich in betaine, one of the choline metabolites, and suppresses fat accumulation in the liver.

Hausoo is a medicinal plant that was introduced from China and has been cultivated for a long time. It has no hair on its entire body, and its roots extend into the ground, sometimes forming round tubers. The weak character is warm, sweet, and crumbly. It is known to have the efficacy of tonic, gangjeong, yanghyeol, bogan, geopung, and sojong. It is used as a treatment for symptoms such as physical weakness, back pain, arteriosclerosis, amniotic fluid, high blood pressure, chronic hepatitis, tuberculous lymphadenitis, enteritis, carbuncles, and constipation.

Astragalus is a plant belonging to the legume family and is used to treat chronic fatigue, loss of appetite, anemia, wound recovery, fever, allergies, uterine bleeding, and uterine prolapse.

Chrysanthemum chrysanthemum, also called yellow chrysanthemum (黃菊), is an annual plant of the dicotyledonous plant Campanula order Asteraceae. In oriental medicine, it is prescribed for the treatment of fever, pneumonia, bronchitis, headache, gastritis, enteritis, boils, etc.

Sangji is a medicinal herb made from the dried young branches of the mulberry tree or other plants of the Moraceae family. The leaves are called upper leaves and are used to raise silkworms or for medicinal purposes. The fruit is called Sangsimja or mulberry and the root bark is called Sangbaekpi and is used for fever relief, antitussiveness, diuresis, and treatment. .

Cypress is an evergreen tree of the gymnosperm cone family Cupressaceae and is known to have hemostatic properties.

Angelica is a representative medicinal plant that suppresses beta-amaloid components that cause dementia and removes free radicals. It helps menopausal women by activating estrogen function, reduces inflammation, and has the effect of preventing brain disorders such as Alzheimer's and Parkinson's. It improves cognitive performance and memory, and the ingredient decusin has anti-cancer effects against lung cancer and colon cancer. It also has a weight loss effect by preventing the growth of fat cells. When you smell angelica oil, dopamine is secreted and it is said to be effective in quitting smoking. It is also effective in preventing skin aging. There is a difference in efficacy between true angelica root and angelica root. True angelica root has blood circulation and anti-cancer effects and is known to be good for gynecological diseases. Angelica root contains folic acid and vitamin E, which helps improve immunity. The blood-replenishing effect of Chinese angelica and Japanese angelica is stronger, and true angelica has a stronger blood circulation effect.

Seokchangpo is a monocotyledonous plant and is a perennial herb of the order Amanaceae. In addition to controlling breathing and smoothing blood circulation, it disperses wind energy and has health, moisturizing, and soothing effects. It is used to treat symptoms of severe stomachache, confusion, forgetfulness, and epilepsy. It is also used for symptoms such as indigestion, stomach pain, abdominal pain, malignant boils, bruises, and red bloodshot eyes.

Black sesame, also called black sesame, is a dicotyledonous plant and an annual member of the sesame family of the sesame family. Unlike other sesame seeds, black sesame seeds contain anthocyanin pigments, which have a strong antioxidant effect and are an effective food for restoring vision and treating diabetes.

Nasturtium is a dicotyledonous plant and an annual herb of the Asteraceae family of the order Campanula. It has effects such as hemostasis, healing, and strengthening (helping stamina), and strengthens muscles and bones. Applicable diseases include hematemesis and nosebleeds, hematochezia, hematuria, trauma bleeding, colitis, dysentery, diphtheria, macrophagia, white and thick urine, graying hair, low back pain due to lack of energy, wet and itchy genitals, etc. It is also used for governing.

Geumjeoncho is a medicinal herb made from the whole herb of the primrose family, and it has been found to have anti-inflammatory, analgesic, anti-inflammatory, expectorant, antipyretic, and lower intestinal tension effects. It is used for gallstones, bladder stones, jaundice, bruises, bronchial asthma, chronic bronchitis, cystitis, edema, asplenia, parotitis, carbuncles, and eczema.

Houttuynia cordata is the above-ground part of the flowering stage of medicinal buckwheat from the Trifolium family. It is said that the rich quercitrin component in Houttuynia cordata expands capillaries, clears the skin, and helps relieve skin problems. In addition, it has excellent antipyretic and drainage properties and is used for coughing due to lung abscess, vomiting of blood and pus, pneumonia, acute and chronic bronchitis, enteritis, urinary tract infection, and boils. It is also used when you have a lot of fever and cannot urinate.

Arborvitae is an evergreen tree of the arborvitae family of the gymnosperm conifer subclass Conifer family. It is said to remove bad body odors, emit a fragrant scent, darken hair, and strengthen bones. It is also effective in preventing bleeding in the blood, urine, and colon or rectum, and also prevents high blood pressure and stroke. The seeds of the arborvitae tree are called Baekjain and are used as a nutritional tonic. The ripe fruit is picked in the fall, dried in the sun, and the hard outer skin is removed before use.

Goji leaves are dried leaves of the Goji berry tree. They strengthen the body, replenish essence, reduce fever, and quench thirst. It also eliminates wind odor and improves eyesight. It is used for fever caused by toxins, chest tightness and thirst, red and painful eyes, euthymic stomach, general weakness, high blood pressure, etc.

Moringa is a deciduous tree cultivated in subtropical and tropical regions such as India, Southeast Asia, and Africa. It has effects such as controlling blood sugar and cholesterol, antibacterial, anti-inflammatory, anticancer, and increasing immunity.

Perilla leaflets are the leaves and terminal branches of chazgi or wrinkled leaflets. It is effective in antioxidant, anti-inflammatory, immunomodulatory, soothing, and antibacterial properties.

Injin mugwort is a plant that grows naturally in Korea and is a perennial herbaceous plant of the compositae family. It is also called heat keeper and mugwort. Young shoots of mugwort are mainly used, and it is known to be effective in anti-inflammatory, antibacterial, anti-acne, antioxidant, diuretic, and jaundice effects. The main ingredients include a variety of ingredients, from chlorogenic acid and caffeic acid, which are types of polyphenols, to oleic acid and linoleic acid, which are essential oil components.

Aeyeop is a medicinal herb made from the dried leaves and young stems of yellow sea mugwort, mugwort, or mountain mugwort of the Aster family. It improves circulation to the meridians, eliminates cold wind and cold, warms the stomach, and relieves pain. It also stops bleeding and stabilizes the fetus. Pharmacological experiments revealed that it has coagulation-promoting and antibacterial effects. It is used for pain caused by a weak stomach, cold dysentery, various bleeding, enlargement, irregular menstruation, fetal instability, and infertility.

Morus bark is a medicinal herb made from the root bark of the mulberry tree of the Moraceae family or a plant of the same genus. It has the effect of eliminating waste, suppressing asthma, expelling water, and reducing swelling.

The scientific name for calendula is Arctotheca calendula. calendula Levyns ) is native to the Cape Province of South Africa, but grows wild in various places, including Australia. It contains a large amount of flavonoids, so it has excellent anti-inflammatory and antiviral effects, and its wound healing effect is effective for ulcers, wounds, cracked skin, boils, and eczema.

Graviola has a green skin covered in thorns, has white flesh, and is rich in juice. It is known to be effective in preventing cancer, skin inflammation, dry eyes, night blindness, aging, and high blood pressure.

Rosemary is a dicotyledonous plant and an evergreen shrub of the Lamiaceae family. It has excellent antibacterial and sterilizing properties and is known to have a moisturizing effect.

Laurel is a dicotyledonous plant and an evergreen tree in the Lauraceae family of the order Ranunculaceae. It is used as a stomach laxative or as a medicine to remove boils.

According to one embodiment of the present invention, the effect of preventing and improving hair loss in both women and men was confirmed when applying the shampoo containing the fermented herbal medicine according to the present invention for one month.

Meanwhile, the present invention provides a cosmetic composition containing a fermented extract for preventing, improving or preventing hair loss prepared by the method described above. At this time, the cosmetic composition is for preventing, improving or preventing hair loss.

At this time, the preventive cosmetic composition of the present invention is preferably applicable to the scalp, and may be, for example, a cosmetic composition having the formulation of a hair conditioner, shampoo, hair tonic, hair essence, hair apple, or cosmetic for use on the scalp. .

At this time, cosmetic compositions having the cosmetic formulation include, for example, solution, suspension, emulsion, paste, lotion, gel, water-soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O/W) type. and a basic cosmetic formulation consisting of a water-in-oil (W/O) type.

More preferably, in the cosmetic composition of the present invention, the composition is manufactured containing mugwort extract or fermented mugwort and can be applied to shampoo, hair tonic, hair rinse, hair treatment, and hair ampoule.

Additionally, the cosmetic composition of the present invention may optionally be applied to the skin in the form of an aerosol or foam booster, or may be applied to the skin in a solid or semi-solid form. However, it is not necessarily limited to this type of formulation and can be implemented in any type of formulation that can prevent hair loss or promote hair growth.

Meanwhile, the composition according to the present invention may contain, in addition to the above-described composition, other ingredients that can provide a synergistic effect on the main effect within a range that does not impair the main effect aimed at by the present invention. For example, it may include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. In addition, when the formulation of the cosmetic composition of the present invention is a suspension, the carrier component includes water, a liquid diluent such as ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester. Suspending agents such as microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, or dragacant may be used.

Hereinafter, the contents of the present invention will be described in more detail through the following examples. However, the scope of the present invention is not limited to the following examples, but also includes modifications of the technical idea equivalent thereto.

[ Example 1: Herbal medicine fermented manufacturing]

For the production of fermented herbal medicines, black beans, sophora ginseng, green tea, goji berry, sorghum, astragalus, chrysanthemum, sorrel, cypress, angelica root, iris, black sesame, nasturtium, geumjeoncho, Houttuynia cordata, arborvitae, columbine leaves, moringa, and perilla leaves. , mugwort, cotyledon, eucalyptus, calendula, graviola, rosemary, and laurel were each cut into pieces with a diameter of less than 5 cm. These herbal medicines were mixed in the mixing ratio shown in Table 1 below to prepare a mixture, and then the herbal medicine extract was prepared through the following extraction process.

First, sterilized water was added to the herbal medicine mixture in an amount 12 times the weight of the herbal medicine, and primary extraction was performed at 2°C for 24 hours. Afterwards, the low-temperature primary herbal medicine extract was collected and stored separately. Afterwards, sterilized water 12 times the weight of the herbal medicine was added to the herbal medicine mixture from which the low-temperature primary herbal medicine extract was removed, and high-temperature secondary extraction was performed at 95°C. Afterwards, the high-temperature secondary herbal medicine extract was collected and mixed with the low-temperature primary herbal medicine extract stored above. It was then concentrated to 5Brix (based on sugar content) and used as a culture medium.

To the culture medium prepared above, 12% (w/v) of brewer's yeast ( Saccharomyces spp.) was added to the medium and cultured with shaking at 20°C for 3 days.

Afterwards, brewer's yeast ( Saccharomyces spp. ) was added at 3% (w/v) relative to the medium, cultured for 2 days at 27°C, and sterilized using a 0.22㎛ filter to prepare fermented herbal medicine.

The detailed composition of the herbal medicines (including brewer's yeast) used in the herbal medicine fermentation product is shown in Table 1 below.

Raw material weight part black beans 7 Gosam 6 green tea 5 Wolfberry 5 Hasoo 5 Astragalus 4 Gamguk 3 upper limb 3 cypress 3 Angelica 3 Seokchangpo 3 black sesame seeds 3 Nasturtium herb 3 money candle 3 Houttuynia cordata 3 arborvitae tree 3 Koo Ki-yeop 3 moringa 3 Perilla leaf 3 Mugwort 3 Love 3 Morifolia 3 calendula 3 graviola One Rosemary One bay tree One

[ Example 2: Manufacturing of anti-hair loss shampoo]

A shampoo containing the fermented herbal medicine prepared in Example 1 was prepared. For this purpose, polyquaternium-10 dispersion was prepared by dispersing polyquaternium-10 in purified water. In addition, disodium EDTA, glycerin, disodium laureth sulfosuccinate, cocobetaine, decyl glucoside, caprylyl glycol, glyceryl caprylate, and ethylhexyl were added to the fermented herbal medicine prepared in Example 1. After adding glycerin and citric acid, the mixture was heated at 75°C for 5 minutes and then cooled to 45°C to prepare a herbal medicine mixture.

Afterwards, the polyquaternium-10 dispersion was added to the herbal medicine mixture and stirred for 5 minutes. Afterwards, lavender oil was slowly added and stirred for 5 minutes to prepare shampoo.

The detailed composition used to prepare the shampoo is shown in Table 2 below.

Raw material weight part Purified water 33.70 Oriental medicine fermentation extract 30.00 Disodium EDTA 0.05 Polyquaternium-10 0.50 glycerin 2.00 Disodium Laureth Sulfosuccinate 10.00 Coco Betaine 17.00 Decyl Glucoside 5.00 caprylyl glycol 0.40 Glyceryl Caprylate 0.40 Ethylhexylglycerin 0.30 Citric Acid 0.40 Lavender oil 0.25 total 100

[ Experiment example 1: Hair loss alleviation clinical trial]

It was intended to confirm the hair loss prevention effect of using the shampoo according to the present invention.

For this purpose, people diagnosed with alopecia by researchers were asked to use the test product on their scalp and hair for one month, and an expert's visual evaluation was conducted on the hair loss improvement effect after use.

As a result of using the shampoo according to the present invention for one month, the effect of preventing and improving hair loss was confirmed in both female and male testers (Figures 1 and 2). Figures 1 and 2 show the results of comparing the hair loss prevention and hair growth promotion effects of female and male testers, respectively, after applying the fermented herbal medicine shampoo according to the present invention for one month.

Claims (5)

Compared to the total weight of herbal medicine, 5-10 parts by weight of black beans, 4-9 parts by weight of sophora ginseng, 3-7 parts by weight of green tea, 3-7 parts by weight of goji berry, 3-7 parts by weight of sage root, 2-6 parts by weight of astragalus, 2 parts by weight of chrysanthemum chrysanthemum ~4 parts by weight, Sangji 2-4 parts by weight, Cypress 2-4 parts by weight, Angelica 2-4 parts by weight, Seokchungpo 2-4 parts by weight, Black Sesame 2-4 parts by weight, Nasturtium 2-4 parts by weight, Geumjeoncho 2 ~4 parts by weight, Houttuynia cordata 2-4 parts by weight, Arborvitae 2-4 parts by weight, Guji leaves 2-4 parts by weight, Moringa 2-4 parts by weight, Perilla leaf 2-4 parts by weight, Artemisia 2-4 parts by weight , 2 to 4 parts by weight of leaf, 2 to 4 parts by weight of bark, 2 to 4 parts by weight of calendula, 0.5 to 1.5 part by weight of graviola, 0.5 to 1.5 part by weight of rosemary, and 0.5 to 1.5 part by weight of laurel with water. After adding, low-temperature extraction at 0-4°C to obtain a primary herbal medicine extract (a);
After step (a), the extract is filtered and water is added to the remaining herbal medicine mixture, followed by high-temperature extraction at 80 to 100°C to obtain a secondary herbal medicine extract (b);
Step (c) of mixing the primary herbal medicine extract obtained in step (a) and the secondary herbal medicine extract obtained in step (b), inoculating brewer's yeast ( Saccharomyces spp.), and performing primary fermentation; A method for producing a fermented extract for preventing, improving or preventing hair loss, characterized in that it is manufactured comprising.
According to paragraph 1,
The primary fermentation of step (c) is,
A method for producing a fermented extract for preventing, improving or preventing hair loss, characterized by fermenting at 15 to 23 ℃ for 2 to 5 days.
According to paragraph 1,
The method for producing the fermented extract for preventing, improving or preventing hair loss is,
After the primary fermentation of step (c), step (d) of inoculating brewer's yeast ( Saccharomyces spp.) and performing secondary fermentation at 25-30°C for 1-3 days; characterized in that it further comprises Method for producing fermented extract for preventing, improving or preventing hair loss.
A fermented extract for preventing, improving or preventing hair loss prepared by the method of claim 1.
A cosmetic composition for preventing, improving or preventing hair loss comprising the fermented extract prepared by the method of claim 1.