KR101663978B1 - Oral composition containing fermented herb extract for anti- gingivitis - Google Patents

Abstract

More particularly, the present invention relates to an oral composition containing a fermented herbal extract, which comprises fermenting a herbal raw material having anti-inflammatory, antimicrobial, antioxidant and blood circulation promoting effects to yeast to relieve inflammation of the gums, The present invention relates to a composition for oral cavity which is excellent in preventing gum disease. In addition, the herbal fermented extract of the present invention has excellent feeling of use by improving the bitter taste and aroma unique to oriental herbal ingredients.

Fermented herbal extract * Prevention of gum disease * For oral use

Description

[0001] The present invention relates to an oral composition containing fermented herb extract for anti-gingivitis,

More particularly, the present invention relates to an oral composition containing a fermented herbal extract, which comprises fermenting a herbal raw material having anti-inflammatory, antimicrobial, antioxidant and blood circulation promoting effects to yeast to relieve inflammation of the gums, The present invention relates to a composition for oral cavity which is excellent in preventing gum disease. In addition, the herbal fermented extract of the present invention has excellent feeling of use by improving the bitter taste and aroma unique to oriental herbal ingredients.

In general, oral compositions designed to prevent gum disease include synthetic materials such as sodium chloride, allantoin chlorohydroxy aluminum, aminocaproic acid, and tocopherol acetate. However, as interest in natural extracts has increased recently, studies on various plants have been actively conducted. As the effects on oral cavity have been known, many extracts have been applied to oral compositions related to prevention of gum disease and bad breath control.

Many plant extracts have been used for the purpose of promoting oral hygiene, but in most cases they have a poor antimicrobial effect or simply prevent the occurrence of periodontal disease through abstract efficacy such as anti-inflammatory, astringent, hemostatic, and promoting blood circulation. .

In addition, it is known that herbal ingredients help prevent oral diseases, but the effect is not so great, and there is a problem that the feeling of use is poor due to the bitter taste and aroma unique to herbal ingredients.

Accordingly, the inventors of the present invention have found that the herbal fermented extract has good bitterness and aroma unique to oriental herbal medicine, and has good feeling in use, And thus the present invention has been completed.

Accordingly, an object of the present invention is to provide an oral composition which is excellent in use feeling, has a high oral disease prevention effect, and is good for gums.

To achieve the above object, the present invention provides an oral composition containing a herbal fermented extract obtained by fermenting a herbal raw material with yeast.

The composition for oral use of the present invention contains a herbal raw material containing anti-inflammatory, antimicrobial, antioxidant and blood circulation promoting effect by fermenting it as yeast, so as to relieve inflammation of the gums and effectively inhibit gum disease bacteria. In addition, by fermenting the herbal ingredients, the bitter taste and aroma unique to herbal ingredients are improved, and the feeling of use is excellent.

The present invention provides an oral composition containing a herbal fermented extract obtained by fermenting a herbal raw material with yeast.

Hereinafter, the present invention will be described in more detail.

The herbal fermentation extract of the present invention is prepared by fermenting a herbal ingredient with yeast. Antioxidant, antioxidant and blood circulation promoting effect can be used as raw materials for oriental medicine. Examples of the herbal raw materials which can be used are gangguk, macki, sechangpo, shiitake, giugi, wormwood, ginseng, ginseng, And at least one selected from the group consisting of garlic, black pepper, and black bean.

Chrysanthellum Indicum is a perennial herbaceous plant of Cercopithecidaceae, which is used as a medicinal herb to be eaten or applied in the period of sympathicotomy. It is also known to be effective against wound healing and convergence by exhibiting encephalopathy, detoxification, hanging, and antibacterial effects. It contains essential oils, glycosides, vitamins A, B1, tannins and saponins.

Portulaca oleracea L. is an annual herbaceous plant with dicotyledonous plant legs. It is known to have detoxification, drainage and diuretic action in the treatment of bronchial asthma. It calms the skin irritation and allergic reaction and shows anti-inflammatory and antibacterial effects. Vitamin B1, C, carotene, nicotinic acid, tocopherol, and saponin are the main ingredients.

Acorus gramineus (Acorus gramineus) is a genus of Acanthaceae, which grows in the mountains and in the fields. Rosaceae have sedative and antipyretic properties and are used as sedatives, analgesics, and placebo in the treatment of migraine. The activity of various essential oils shows antibacterial and blood circulation promoting effect.

Rumex japonicas is a perennial plant of the dicotyledonous plants of the order Cucurbita spp., Growing mainly near the wetlands. It has excellent antimicrobial action and is used for alveolar rash and gum inflammation prevention. The main ingredients are tannin, flavanoid, saponin, vitamins A and C.

Lonicera japonica Thunb is a semi - evergreen plant of the dicotyledonous plant of the dicotyledonous plant. Its pharmacological experiments have shown that it is effective against acne, immunity, anti - inflammatory, analgesic, diuretic and antiviral activity. Main ingredients include luteolin, inositol, and linoleic acid.

Mugwort (Artemisia vulgaris L.) is a perennial herbaceous plant of the dicotyledonous plant. It has been known to be used as a convergent hemostatic agent, analgesic agent and antitumor medicine in antibiotics. It is known to increase immunity by antioxidant and anti - inflammatory action. The main ingredients are essential oils, folinic compounds, Boneol, vitamins A, B and D.

Rhubarb is a medicine made by drying the roots of Rehmannia glutinosa Liboschitz var. Purpurea Makino. In China, dried persimmon is called 生地 黄 (生地黄). Gwanghwang is a herbaceous medicinal plant belonging to the ginseng family, and its roots are used as medicinal materials in one room. It is said that raw ginseng is called dried ginseng and dried ginseng, and dried ginseng is made 9 times. The drug is the best. It has a bitter taste with a bitter taste, but it has a warm temperament, and it replenishes its blood and replenishes its essence (a substance that is fundamental to life and activity). It causes back and knee pain, sore symptoms, menstrual disorder, dizziness It has the efficacy to cure the head and darken the head. Zhou Hui is one of the ancestral tablets, and its herb has detailed descriptions of its effects on hair. "Two of the dried persimmon and waterweed are a good medicine to make beard and hair darker, and it is good to eat pills or drink and eat." Especially, in the case of Sukjihwang, it is used as a medicinal product for the blood, consonants, and medicines to have a positive nature through the use of raw persimmon and through various legal process. Chiguan is a medicinal product that improves circulation and improves healthy hair.

Panax ginseng is a Panax ginseng cultivar belonging to Araliaceae. It grows in a deep mountain forest. Ginseng roots have long been used for medicinal purposes and are called ginseng because the form is human. The roots of ginseng cultivated in Korea are hypertrophic roots and have two roots and five root roots and are yellowish white. The number of rootstock varies depending on soil, transplanting method, fertilizer, moisture, etc., but it is a plant with strong branching ability. Its root shape varies with age and harvesting time is 4 ~ 6 years. The efficacy and efficacy of ginseng has long been studied. From ancient times, ginseng has been referred to as flour, jangsu, 益气 (益气) It is also known that it has various effects and effects such as skin cell regeneration and wrinkle improvement as cosmetic raw materials, and it supplies nutrition to scalp and hair, gives shine to hair, prevents hair loss, Although it is known to be effective, its efficacy and effectiveness are very poor.

Bokyeong is a sclerot of Poria cocos Wolf which is parasitized on the root of pine, and is a medicinal substance which is made by removing almost the outer layer. It is said that Bokryeong is written in the old literature as "Bongryeong" and "Bokseong" because it is thought that the spiritual energy of the pine tree penetrates into the earth and is united. There is also a record of defeating disaster. It is said that the name "笭" was born in the meaning of the remaining command (零). If the pine tree is not strong enough, it grows around the root of the tree and does not fall off from the root It is said that this is called a double-skinned rope. The taste is sweet and bored, the quality is flat, and there is a function to complement, and diuretic action, but not strong. It has long been used as a tonic. It acts on menopause (肺 经), necrosis (脾 经), heart (心 经), nerve (肾 经) and bladder (bladder) to see the spleen, Pharmacological studies have shown that diuretic action, lowering of blood sugar level, sedation, etc. It is also known that the immune revival function. The spleen is hung (虛) to swell the body and used in the bottle. In addition, Ghee also prescribes dna, revenge, diarrhea, amnesia, and sleep disorder. It is known to have excellent effects on diseases such as stomach, liver, stomach, and kidney, and is used as a medicament for the treatment of a weak person or a chronic gastrointestinal patient after suffering from a disease. It is also known to be effective against sexually transmitted diseases as well as sexually transmitted diseases and women's diseases.

Green tea (Thea sinensis Linnaeus) is an evergreen tree or shrub belonging to the tea tree (Theaceae). Green tea is the next most widely consumed beverage, and its efficacy has long been studied. Green tea, black tea and oolong tea are produced from the leaves. The green tea is obtained by inactivating oxidation-related enzymes by steaming tea leaves, stems or flowers, and stably maintaining the polyphenol component. The polyphenol component found in green tea is known as flavonol and catechin, and has been known to have various effects such as antioxidant, anticancer, antiinflammation, and antibacterial, and is widely used as a cosmetic raw material.

Ganjang (當 药) is a phytoplankton, the outpost of the phyla, which has been called medicinal for a long time. Swertia (Swertia japonica Makino) belongs to the gentleness of Yongdam. It is a biennial plant that grows in sunny hills, hills, meadows, and bright pine forests. Until the end of the year, it is elliptical, with two to four rosette-shaped rootstocks, which grow in height from 5 to 20 centimeters in height, reaching purplish stems from the spring of next year. In autumn, white flowers with five petals bloom and when they bear fruit, they wilt. The fruit is barrel-shaped and the seeds are very small.

About 80 species are distributed throughout the world and many species are growing in Korea. It has been found that the species of bitterfly that grows in Korea is the bitter bloom, the bitter apple, the bitter apple, the bitter apple, the bitter apple, the bitter apple, and the big leaf. It is 5 to 20 cm tall and the stem is straight, purple, and hairless. Leaves are flat, sharp-tipped leaves face each other, and there are no petiole. The flower is white and has a white petal with five petals and a narrow purple stripe pattern. It can be used for the treatment of alopecia, skin protection, fever, fever, stomach uptake, dampness, indigestion, lack of appetite, gastritis, jaundice, gastritis, eye disease, toothache, frog, chronic bacterial dysentery, abdominal pain, Conjunctivitis, is said to have an effect on improvement.

Polygonum multiflorum is a vineous perennial plant belonging to Polygonaceae. Chrysophanol, Emodin, lecithin, etc., which are oxymethyl anthraquinone derivatives, have. Some records say that there are deficits and white porcelain in the records of some ancient books, and they are called enemy Suseo and Baekseoso. Sasao effectively absorbs ultraviolet rays and is effective as an antioxidant for scalp and hair. It is effective in preventing skin and scalp aging through antioxidant and astringent action.

Black beans are cultivated widely as edible crops as soybean and Glycine max varieties. The fruit is cone (果果), a flat oval in the shape of a line and contains 1 to 7 seeds. When fully ripe, the pod bursts and the seeds are scattered. Depending on the variety, seeds are round, flat and round in shape and vary in size. Seed color is yellow, black, light brown, green, etc. There are many. In particular, black seed color is called black bean (black bean).

The herbal fermentation extract of the present invention can be produced by a conventional production method in the art, and the method is not particularly limited. Specifically, for example, the herbal raw materials may be placed in a fermenter, purified water and dry yeast may be added, and the mixture may be cultured at room temperature for 24 hours, and then natural products may be removed and heat-treated (80 to 90 ° C for 30 minutes) and filtered.

The herbal fermented extract of the present invention is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. If the content is less than 0.01% by weight, the effect is insignificant. If the content exceeds 10% by weight, the unique bitter taste of the one-shot raw material is increased and the feeling of use is lowered.

Hereinafter, the present invention will be described in more detail by way of examples and test examples, but the scope of the present invention is not limited to these examples.

[Preparation Example 1] Preparation of Oriental Fermented Extract

Ginseng, green tea and black bees were selected and adjusted according to the theft of the general rules of the pharmacopoeia. Then, 400 g of green ginseng, 600 g of green tea and 400 g of black tea were added to the fermenter, and 15 Kg of purified water and 100 g of dry yeast were added thereto and cultured at 25 ° C. for 24 hours. After the cultivation was completed, the natural products were firstly removed, and heat treatment (80 to 90 ° C, 30 minutes) was performed to extract and inactivate the cultured yeast, followed by filtration with diatomite to obtain about 8 kg of yeast fermentation broth. After 136 kg of ionized water was mixed, 6 kg of a solution obtained by dissolving a preservative (Phenonip) in 1,3-butylene glycol was mixed and stirred. The mixture was pre-filtered using a 1.0 탆 filter and micro-filtered using a 0.45 탆 filter to prepare a herbal fermented extract of about 150 kg.

[Preparation Example 2] Preparation of general oriental oriental herb extract

Ginseng, green tea and black pear were selected and adjusted according to the theft of the general rules of the pharmacopoeia. Then, 400 g of green ginseng, 600 g of green tea and 400 g of black pear were added to the reactor, and 15 kg of purified water was added thereto and allowed to stand at 25 ° C for 24 hours. First, natural materials were removed and heat treated (80 ~ 90 ℃, 30 minutes), followed by diatomaceous filtration to obtain an extract of about 8 kg. After 136 kg of ionized water was mixed, 1,3-butylene glycol dissolved in a preservative (Phenonip) was mixed and stirred. Pre-filtration was performed using a 1.0 μm filter and micro-filtration was performed using a 0.45 μm filter to prepare a general herbal extract of about 150 kg.

[Example 1 and Comparative Examples 1 and 2]

Example 1 of the toothpaste formulation and Comparative Examples 1 and 2 were prepared according to the composition of Table 1 below. Example 1 contained a herbal fermented extract, Comparative Example 1 contained a common oriental oriental extract, and Comparative Example 2 contained a herbal extract.

ingredient Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Sodium fluoride 0.30 0.30 0.30 Precipitated silica 15.00 15.00 15.00 Fermented Herbal Extract (Preparation Example 1) 1.0 - - General Oriental herb extract (Preparation Example 2) - 1.0 - Sorbitol solution 50.00 10.00 10.00 Sodium carboxymethylcellulose 1.00 1.00 1.00 Sodium saccharin 0.25 0.10 0.10 Paraoxybenzoic acid methyl 0.20 0.20 0.20 Spices 1.00 1.00 1.00 Sodium lauryl sulfate 2.00 2.00 2.00 Purified water To 100 To 100 To 100

[Test Example 1] Measurement of gum disease prevention effect

The gingival index was measured to confirm the gum disease prevention effect. First, after screening 60 subjects, they were not allowed to take oral medications that could affect the antibiotic dosing and experimentation during the experimental period. Twenty subjects were each divided into Example 1 and Comparative Examples 1 and 2, and the gingival index was measured according to the following evaluation criteria. The results are shown in Table 2 below.

<Evaluation of gingival index of Loe modified by Talbott, Mandel and Chilton>

0: No inflammation

1: mild gingivitis (weak change of color tone and weak edema) - No bleeding in periodontal pouch

2: Middle gingivitis (redness, edema) - Hemorrhage in measuring periodontal pouch

3: High grade gingivitis (ulcer) - tendency to bleed spontaneously

division Example 1 Comparative Example 1 Comparative Example 2 Initial value 0.88 0.20 0.90 + - 0.38 0.86 ± 0.19 4 weeks 0.42 ± 0.34 0.75 + 0.27 0.73 + - 0.25 8 weeks 0.17 ± 0.19 0.58 0.21 0.69 0.21 Improvement index 0.71 + - 0.22 0.32 ± 0.26 0.17 ± 0.23

The results of Table 2 show that Comparative Example 2 containing no herbal extract had almost no gingivitis relieving effect and Comparative Example 1 containing general herbal extract showed a certain degree of gingival improvement effect, The gingiva-improving effect of Example 1 was far superior to that of Comparative Example 1. Therefore, it was found that the herbal fermentation extract obtained by fermenting the herbal raw material of the present invention with yeast significantly improved the gum disease prevention effect than the conventional herbal extract.

[Test Example 2] Bitter taste sensory evaluation

1 g of toothpastes dipped in saliva were applied to the toothpastes of Comparative Examples 1 and 1, which had been one week old, and 30 subjects (10 males, 20 females, 25-35 years of age, ) Were rinsed for 3 minutes, washed 5 times with water, and then evaluated for bitter taste of toothpaste immediately after brushing on a 5-point scale. The sensory evaluation results of bitter taste of toothpaste are shown in Table 3 below. At this time, the ingestion of food was prohibited during the measurement time after brushing.

division Example 1 Comparative Example 1 Bitter 1.3 3.5

Evaluation Criteria: Very Write (5 points), somewhat write (4 points), write (3 points), slightly write (2 points), write (1 point)

The results of Table 3 show that the bitter taste of Example 1 containing the herbal fermented extract in the toothpaste was significantly lower than that of Comparative Example 1 containing the common herbal extract. Therefore, it was found that the herbal fermented extract of the present invention has a distinctive bitter taste of herbal ingredients, which is excellent in feeling of use.

Claims (4)

A composition for oral cleaning comprising a fermented extract obtained by adding a mixed solution of water and a glycol compound to a yeast fermentation broth of ginseng, green tea, and black bean and then filtering. The oral cleaning composition according to claim 1, wherein the ginseng, green tea, and black bean are mixed at a weight ratio of 2: 3: 2. The oral cleaning composition according to claim 1, wherein the fermentation extract is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. The oral cleaning composition according to claim 1, wherein the glycol compound is 1,3-butylene glycol.