KR101805004B1 - Fermentation method using medicinal leaf and skin external composition containing fermented extract by the method - Google Patents

Abstract

The present invention relates to a composition for external application for skin containing a fermented extract of palm fronds using medicinal leaves. More particularly, the present invention relates to a composition for external application to skin comprising antimicrobial extracts, And to a composition for external application for skin excellent in moisturizing effect.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a fermentation method using medicinal leaves and a skin external application composition using the medicinal leaf,

The present invention relates to a composition for external application for skin containing a fermented extract of palm fronds using medicinal leaves. More particularly, the present invention relates to a composition for external application to skin comprising antimicrobial extracts, And to a composition for external application for skin excellent in moisturizing effect.

The human skin undergoes changes due to various internal and external factors as it gets older. In other words, internally, secretion of various hormones that regulate metabolism is reduced, the function of immune cells and the activity of cells are lowered, and the biosynthesis of immune proteins and biocompatible proteins necessary for the living body is reduced, and ozone layer destruction As the amount of ultraviolet rays reaching the surface of the sunlight increases and the environmental pollution is further intensified, free radicals and active noxious oxygen are increased, thereby decreasing the thickness of the skin, increasing the wrinkles and decreasing the elasticity Skin color is also dull, skin troubles occur frequently, and spots, freckles, and black spots also increase.

As the aging progresses, the content and arrangement of collagen, elastin, hyaluronic acid, and glycoprotein, which constitute the skin, are changed or decreased, and oxidative stress due to free radicals and active noxious oxygen is experienced. Cox-2 (cyclooxygenase), an enzyme that produces a proinflammatory cytokine, known to cause inflammation in most cells constituting the skin by aging or ultraviolet rays, And the biosynthesis of Matrix metalloproteinase (MMP), an enzyme that degrades skin tissue, is increased by these inflammatory factors, and nitric oxide (NO) production by iNOS (inducible nitric oxide synthase) Respectively. In other words, decrease of cellular activity due to natural endogenous aging and decrease of biosynthesis of substrate material by microinflammation, increase of stress due to various harmful environment, increase of active oxygen species by sunlight, As the degradation and denaturation are accelerated, the skin substrate is destroyed and thinned, and various symptoms of skin aging appear. Therefore, it is a reality that many researches have been conducted on active ingredients that can prevent and improve such aging phenomena.

On the other hand, active oxygen generated by various physical, chemical, and environmental factors such as in vivo enzymatic system, reductive metabolism, chemical agents, pollutants and photochemical reaction, etc. is non-selective, irreversible It is known to cause various diseases including cancer or aging cells by destructive action. In addition, lipid peroxides and various peroxides such as lipid peroxides produced as a result of lipid peroxidation by these active oxygen also cause oxidative destruction to cells and cause various dysfunctions and cause various diseases. Accordingly, antioxidants such as free radical scavengers or peroxidation-inhibiting substances are expected to be used as agents for inhibiting or treating various diseases caused by these oxides.

Recently, there is a growing demand for natural fermentation methods using natural fermentation methods in which artificial elements are not added due to trends such as well-being, and there is a continuing demand for products utilizing them. However, such a natural fermentation method is difficult to utilize as an actual product due to the risk of corruption and pollution caused by Escherichia coli and anaerobic bacteria harmful to human body. In order to solve this problem, a method of sterilization before fermentation such as boiling is devised, but it is necessary to develop a fermentation method by a non-sterilization method because the efficacious ingredient etc. may be destroyed by heat.

Recently, as interest in traditional fermented foods has increased, various methods for producing extracts using such fermentation techniques have been developed. Accordingly, the development of functional foods, cosmetics and the like using natural product extracts having superior performance to those of existing natural products has been continuing.

The inventors of the present invention have found that natural fermented extracts obtained by fermenting natural fermented foods by wrapping or covering natural products with medicinal leaves as compared with conventional natural and fermented extracts have been found to be effective for skin antioxidant , Anti-aging, whitening and moisturizing effect, and completed the present invention.

Accordingly, it is an object of the present invention to provide a composition for external application for skin, which comprises a cosmetic fermented extract having excellent skin efficacy and is excellent in skin antioxidation, anti-aging, whitening and moisturizing effect.

In order to attain the above object, the present invention provides a composition for external application for skin, which comprises a fermented extract of spinach produced by wrapping or covering a natural product with medicinal leaves.

In addition, the present invention relates to a method for producing a natural product, which comprises boiling or steaming the washed and dried natural product for 30 minutes to 2 hours;

Cooling the boiled or natural product for 30 minutes to 1 hour at room temperature;

Wrapping or covering the cooled natural product with medicinal leaves and fermenting the mixture in a dark place for 4 to 7 days at room temperature; And

Removing the medicinal leaves from the fermented natural product and extracting the leaves;

The present invention provides a method for producing an extract of fermented sesame seeds.

The medicinal leaf-leaf fermented extract according to the present invention shows excellent skin effect against antioxidation, anti-aging, whitening, moisturizing and the like compared with the natural extract before fermentation or the natural fermentation extract. Available.

The present invention provides a composition for external application for skin containing a fermented extract of spinach produced by wrapping or covering a natural product with medicinal leaves.

In addition, the present invention relates to a method for producing a natural product, which comprises boiling or steaming the washed and dried natural product for 30 minutes to 2 hours;

Cooling the boiled or natural product for 30 minutes to 1 hour at room temperature;

Wrapping or covering the cooled natural product with medicinal leaves and fermenting the mixture in a dark place for 4 to 7 days at room temperature; And

Removing the medicinal leaves from the fermented natural product and extracting the leaves;

The present invention provides a method for producing an extract of fermented sesame seeds.

Hereinafter, the present invention will be described in more detail.

The medicinal leaves that can be used in the present invention may be selected from the group consisting of mulberry leaves, lower leaves, marigold leaves, canola leaves, bamboo leaves, wormwood leaves, mint leaves, ginseng leaves, green tea leaves, zucchini leaves, persimmon leaves, And nuchu-kiwi leaves.

Mulberry leaves are called mulberry leaves. The upper leaves are used for fever, headache, eye congestion, seawater, dry eye, skin rash. This medicine is sweet and spicy, and its quality is cold. The pharmacological action of antidiabetic action, typhoid bacillus, Staphylococcus aureus and has been reported to inhibit.

It is a leaf of lotus which is a perennial aquatic herbaceous plant belonging to a water lily field. In general, the lower leaves are known to have a hemostatic effect, and the effect of the seaweed action and blood pressure has been reported.

Leaf of Leaf is Leaf of Adenophora triphylla var. Japonica Hara which is a perennial plant of perennial plant. Leaves from roots are long petiole, almost circular, or dry when they have flowers. Jinhae, geomdan, fever, tincture, drainage agent is used.

The canola is the leaf of the soybean (Glycine max) which is an annual plant of the dicotyledonous plant rosemary bean. It contains a large amount of vegetable protein and can reduce the cholesterol in the body, and can exert excellent effects as a source of protein and fiber.

Bamboo leaves are the leaves of evergreen perennial plants belonging to the bamboo flies of the unicorn plants. Roofing material, animal feed, food packaging, antipyretic and antidote.

Artemisia mongolica, A. asiatica, A. princeps, and A. argyi are perennial herbs belonging to the Compositae family. They are native to many countries and have a unique aroma and taste. It has been reported that it prolongs blood coagulation time, has anticancer effect, has antifungal action, anti-complement action, and has a defense system of host, which is effective for allergies and inflammation, hypotensive action and sedative action.

Mint leaves are leaves of peppermint (Mentha arvensis L. var. Piperascens). Menthol is contained in the ground part in an amount of 70 to 90% by weight, and essential oil is contained in 1% by weight. Other essential oil components include isomenthone, neomenthol, pinene, camphene, and L-limonene, and high boiling components such as gamma-hexenolphenylacetate and ethylamyl ketone. The essential oil component of the mint leaf varies depending on the variety, but recently it has been known that various components such as linalool as a main component are known. The main ingredient, menthol, is used as an anti-foaming agent, analgesic agent, stimulant, and texturizer, and is used as a fragrance or refreshing agent in toothpaste, candy, jam, cosmetics, and tobacco.

Panax ginseng C.A.Meyer Leaves are ginseng leaves. Ginseng leaves are long petiole, and the leaves are divided into 5 pieces to form palmate compound leaves. Small leaves are small on the outside, three in the middle are 4.5-15cm long, and 3-5.5cm wide with sharp tips, with sharp sawtooth on the edges. Saponin and various enzymes are contained in the leaves of ginseng. Saponin analysis of ginseng leaves revealed that ginsenoside-Rd (ginsenoside-Rd), ginsenoside-Re (ginsenoside-Re) and ginsenoside-Rg1 (ginsenoside-Rg1) and the like were detected as the main components of saponin. In addition, -Rb1, -Rb2, -Rc, -Rf, -Rg2 and the like were detected as trace saponin components.

Green tea leaves are leaves of tea (Camellia sinensis) which is a plant of Camellia sinensis. It is antioxidant, antitumor, blood cholesterol lowering, anti-aging, heavy metal detoxification, And has been attracting much attention as it has proved the effects of removing bad breath.

The zucchini leaf is characterized by a broad leaf and a lot of hair. It is rich in fiber and vitamins, and low in calories, so it is good for diet foods. It is also known to eliminate the oxidative substances in the body and also to have an anticancer effect.

Persimmon leaves contain flavonoid glycosides, tannins, phenols, resins, saccharin compounds, reducing sugars, polysaccharides, essential oils, organic acids, chlorophyll, etc. Flavonoid glycosides include astragalin and myristyl, Some persimmon leaves in June contain about 100mg of 100g. Persimmon leaves are said to be good for bronchial protection according to our traditional folk remedies, and because it contains a lot of vitamin C, it helps to absorb minerals such as iron that are easily lost after drinking, so it is said to be good for hangover.

The leaf of Vipa is the leaf of Eriobotrya japonica, an evergreen tree of the Rosaceae Rosaceae. Leaf leaves contain vitamins B17 (amikarin) as its main ingredient and contain uronic acid, oleic acid, tannin, saponin and vitamin B1. Vile leaf is effective for relieving breathing, constipation, and poor circulation of heart disease. It is said that it is effective for relieving hangover and gastrointestinal disease after drinking alcohol, cleansing blood, and excelling in adult diseases such as hypertension, neuralgia, arthritis and anticancer effects, and Dongbokgung is also effective for chronic bronchitis, germatosis and thirst.

Leaves are Leaf of Pyrrosia lingua, an evergreen perennial plant of Ganranche. Leaves of stalks are straight and sparse. Long oval or lanceolate, with a green outer surface and a yellowish brown back. It is mainly used for diuretic and gonorrhea treatment. It is used as a medicinal agent for diuretic rheumatism, hemorrhagic hemostasis, hemostasis, openness, arthritis, hematemesis, uricysis, urinary incontinence,

Chamaecyparis obtusa is an annual plant of Lamiaceae which is 30 ~ 60cm high and originates from China. The scientific name is Perillafrutescens Britton var. It is called crispa Decne and is also called jaso (shiso) or 葉葉 (蘇 葉). In addition to its antiseptic effect, chrysanthemum leaves have excellent antiseptic effect, and recently it has been shown to have a high anti-cancer and antiallergic effect and is attracting attention as a well-being planting material. Beta-carotene is abundant in the leaves of Chachoji, and there are many B1, B2, B6, vitamin C, E and K in the vitamin B group, and niacin is also included. Also rich in calcium, iron, potassium, magnesium, zinc and other minerals are abundant.

It is a biennial plant with mustard seeds. It has a function to heat down and detoxify and is used for fever, headache, sore throat, and mildew.

The leaves of Nuri-jinja are the leaves of Clarodendron trichotomum Thunb, a deciduous broad-leaved arboreous tree, and are used for food or medicinal use. Young leaves are used as herbs. When used as medicines, they are used as a bath or as pills or powders. do. It mainly controls the nervous system and circulatory diseases.

The natural products which can be used in the present invention include natural products such as beans, gherkin, ganghwag, ganghwam, gwangguk, gwanggi, ganchul, licorice, Ganhwaseo, Gwanghwago, Chrysanthemum, Gyungyang, Cucumber tree, Nuptial, Male, Ganhakgyo, Mung bean, Deer antler, Chinese cabbage, white cabbage, white cabbage, white rice, white cabbage, sandalwood, white cabbage, white cabbage, white cabbage, red cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, It is the first time in the world that there are many kinds of white porcelains such as white porcelain, white papyrus, white peony, white porcelain, white porcelain, bokbunja, Manganese, manganese, manganese, manganese, manganese, ginger , Yeongbok, Yeonbab, Yeonbab, Yeonbok, Yeonbu, Yeonbu, Yeonji, Yeonji, Ogupi, Omija, Obija, Yeonpyeong, Cheonjae Ginseng, persimmon, ginseng, ginseng, ginseng, yewei, rapeseed, ginseng, ginseng, ginseng, ginseng, ginseng, motherwort, raw ginseng, raw ginseng, Chrysanthemum, Chrysanthemum, Chrysanthemum, Chrysanthemum, Peony, Chrysanthemum, Chrysanthemum, Chrysanthemum, Chrysanthemum, Chrysanthemum, Red Cabbage, Chrysanthemum, Chrysanthemum, Chrysanthemum, Clove, Sculpture, Sculptor, Sage It is the first time in the world that we have a lot of people in the world who want to go to the world of the world. Excess, Chrysanthemum, Gardenia, Blue box, Urgency, Degradation, Tacrine, Taxa, , Red pepper, porcupine, bulbous, inflorescence orchid, dewatering, alliance, passerine, incense ginger, herbalist, ointment, incense, At least one selected from the group consisting of black tea mushroom, black tea leaf, safflower, fur, golden, hwanggi, hwangryun, hwangjeong,

Soy is also called soybeans. It is widely cultivated as an edible crop. Its stem is 60cm ~ 100cm in height and stands straight and has some varieties of vines. The flowers bloom in red or white with mauve red color in July ~ August, and they run in a layered inflorescence on a short peduncle from the axilla. Calyx is bell-shaped and its tip is divided into 5 pieces. The corolla is butterfly shaped, and the operation is 10 pieces. The fruit is narrow, flat, oval in the shape of a line and contains 1 to 7 seeds. When fully ripe, the pod bursts and the seeds are scattered. Seeds vary in size and shape, including round, flat, and round shapes, depending on the variety. Seed color is yellow, black, light brown, green, etc. There are many.

The goat meat is removed from the mature fruit of Gastropoda (Terminalia chebula Retzius) and used in dried flesh to treat diarrhea, dysentery, fever,

It is used for the throat, the fever, the fever, the sweating, the thirst for thirst, the headache, the back pain.

Ganghwang is a biennial plant or perennial plant, with a height of more than 2 meters. Leaves are split, and are alternate phyllotaxis. From August to September, small, white flowers bloom at the end of the branches and the fruit is oval. Roots similar to bellflower are used as antipyretics and analgesics in oriental medicine.

The country is also called Huangguk (黄菊). It grows mainly in the mountains and has short hairs on the whole grass. The height of the stem is 60 ~ 90cm, and it is thin and long black. In October, the flowers are dried and drunk, and young leaves are used as herbs. There is a strong aroma in the flower, and it is also used for ornamental purposes. In one room, it is prescribed for the treatment such as hotness, pneumonia, bronchitis, headache, gastritis, enteritis, boil.

It is the roots of dried rhubarb, which are used as raw materials to lower the fever and to give blood (blood) and hemostasis (hemostasis).

It is used to scrape the lacquer jeans and to dry it. It is used for menstrual disorders, eosinophilia, semicircular canal.

Licorice is a medicinal plant and its roots are reddish brown and deeply penetrates deep into the ground. Also, the white hairs are dense and appear grayish white, and glandular dots are scattered. Flowers bloom in July-August, length is 1.4-2.5cm purple, and roots are sweet, so they are used as sweeteners and medicinal herbs.

Health is used for the treatment of 胃寒, vomiting and diarrhea, which is a dry ginger.

It is said that the seed of morning glory is the seed of the morning glory. The seed of the red flower is called the black shark, and the seed of the white flower is the white shark. Constipation, edema, take (聚聚), such as lumbar puncture.

The killer refers to the seed of a car that is an annual crop of soybeans. The stem is about 1 meter tall and has yellow flowers in summer. The fruit bear an elongated cape like a bow, and the seed in it is the loser.

It refers to the roots and bark of the tree. It is used as insect repellent.

Gobon is a perennial herb that grows at the base of deep mountains and is distributed throughout Korea. It is 30 ~ 80cm in height. There is no hair on the whole grass and it smells. It forms an elliptical fruit and the root is medicinal. In one room, dried roots are cured and dried, and they are prescribed to headache, joint pain, toothache, abdominal pain, diarrhea and eczema.

Gosam is a perennial plant of legumes. The height is 80 ~ 100cm, and in summer, butterfly-shaped pale yellow flower is scattered on the stem and branches end. The root is made medicinal. Gosam usually refers to roots. It is used for jaundice, schizophrenia, and hemorrhage.

It is a deciduous broad-leaved shrub with a height of about 2 meters and has thorns. The leaves are alternate phyllotaxis, and the red flower with butterfly-like shape in spring is bloomed one by one in the leaf axil, and the fruit is ripened in the autumn with a cylindrical shape of pods. It is cultivated for ornamental use and distributed in Korea, China and others.

Guruyin refers to the seeds of a perennial plant, which is a perennial plant of 3 to 5 meters long, with leaves alternating with palms. In July ~ August, purple flowers bloom on the axil and the fruit is yellow and yellow. It is used to remove milk and feces and to calm the boil.

Gugija is an egg-shaped or long elliptical fruit with a length of 1.5-2.5cm. It is reddish from July and harvested in late July to late November. It is used as antipyretic and tonic.

It is a perennial plant of Lepidoptera, and its stem is 20 ~ 30cm in height. It has hairs on whole body, its leaves are ovate, and there are sawteeth. From July to September, a lilac-shaped pale red flower blooms as a total inflorescences. It grows in mountains, but it is distributed in Jeju and Hambuk.

Kwacka is a perennial plant with Bucheoson. Its stem is about 30cm in height and has many branches. Leaves are dark green and scaly. When dry, the branches are shrunken, and when they meet a humid aura, they have the property of re-opening. Menstrual cramps, and low blood pressure.

Citrus peel refers to the skin of a mandarin orange. It is warm in nature to help digestion, and has a medicinal effect such as coughing, diarrhea, and accumulation.

Gwanghwha refers to the flower of a rhododendron, which is used to lower fever and poison.

It is a perennial plant of Asteraceae and its height is 50cm. In September-November, red and white flowers bloom at the end of the stem, fruit bear anchovy, and flowers are eaten in the wine. Herbal medicine is dried stem and leaf, and herbal medicine and private medicine prescribe whole flower with bloom, gynecological disease and gastrointestinal disease.

Chrysanthemum is a perennial plant of Asteraceae and its height is about 1m. It is mostly flowered in fall, but there are many flower shapes and colors. Depending on the size of the flower, it is divided into large country, China, small country.

Gil-gyeong is a perennial herbaceous plant with a height of 40 ~ 100cm. Leaves are alternate and oval. The roots are plump, and one or several stems are gathered. White or light blue flowers bloom from July to August, and the fruit is capsule. Roots can be edible or used as medicines in geomorphic or Jinhae.

It is a deciduous arboreous tree of the banyan tree with many thorns on the branches and hairy on the young branches. Leaves are alternate and occasionally split into three branches. In May and June, male flowers bloom in yellow, and female flowers bloom in a ball shape with a diameter of 1cm. Several fruits are gathered together like a big one and ripen red in September. It is known to be effective in healing tinnitus symptoms.

The nunnery is also called the underwear and refers to the seed of the plant of the crucifixion or of the same species. It is used to control or control the wall.

The male is also known as Nan-san, and is a perennial plant of the Nan-seong area. The height is 30 ~ 60cm, and the leaf is divided into several branches and has the shape of a bird. In May ~ July, green flowers bloom in broth (肉 穗), and the fruit is red berries. It is used to treat feces and sea urchin, paralysis, and stomach.

It is the medicine that makes the deer 's horns like grass, and it has the function of the blood, the hemostasis, the anesthesia. It is used for back pain, gonorrhea, etc.

Mung bean is also called asan bean and 吉 豆. It grows well in warm climates (dark soil with a moderate mixture of sand and clay) and is 30 to 80 cm high. In the private sector, it is used to treat skin diseases.

Deer antler is used as a supplement for strengthening the muscles (muscles) by seeing the Yangki with the soft horns of the new deer.

Sujil is the fruit of the perennial plant, which is the year of saccharification. The roots are in the mud, the stems grow thin and long in the water, they come out on the water and have a feather-shaped root in the water. Leaves are clustered at the top of the stem and are triangular, and there is a bulging bag (浮 囊) with air in the petiole, floating on the water. White flowers bloom in summer, and fruit is edible as a nucleus. It blooms in ponds or swamps and is distributed in Korea, Japan, and China.

Variety is a greenish-yellow vegetable belonging to the cruciferous plant, which contains a lot of vitamins and is called vitamins or vitamins. The carotene content of vitamin A is twice as high as that of spinach, rich enough to fill 80% of the daily requirement of 100 g of vitamins, and rich in iron and calcium.

It is the roots of the perennial herb, which is a perennial herb. It is mainly anti-inflammatory and analgesic.

It is an evergreen schistose, reaching 6m in height. Leaves are large, lanceolate, elliptical, 10 ~ 13cm long, 4 ~ 5cm wide, petiole is 1 ~ 2.5cm long, leafy, large, 0.4 ~ 1cm wide. There is shallow embankment in the chlorophyll. The fruit is obovate, 10 ~ 12cm long, 9 ~ 10cm long, 6 indoor and the weight is usually about 200g, but the bigger is 500g and there is a slight irregularity on the surface.

It is a perennial plant of Asteraceae and is also called thistle. Stems stand straight and 50 to 100 cm high, with white hairs on the whole and cobweb-like hairs. Flowers bloom from June to August, purple to red. Heads and trunks are hanging at the end. It is used as a hemostatic agent.

Soybean is the germination of soybean (Glycine max Merrill). It is used for the symptom of limb paralysis caused by the wet in the summer, the symptoms of the limb gingiva, the symptom with the water pollution, and the symptom with less urine volume. It is also used to reduce heat caused by colds and sweat.

Hemp is a perennial plant of the monocotyledonous plant. Its stem is purplish with thick branches, leaves are alternate, petiole is long, and uneven teeth are on the edge. Flower corolla is trumpet-shaped, light purple, and tubular calyx envelops corolla. The end of the corolla is divided into 5 pieces, 5 stamens and 1 pistil. The fruit is a seedling with a lot of thorns. When ripened in October, it is split into 4 pieces and black seeds come out.

Contrast refers to jujube, also called wood mill (木 蜜). The surface is reddish brown, elliptical, 1.5 ~ 2.5cm long, and has a sweet taste when cooked red. Fruit is not only reproductive, but also dried and dried after being harvested and used as confectionery, cooking, and medicinal products in dried fruits, and used as diuretic, tonic, and emollient in one room.

Daejungcho is a pre-sentence of Hygrophila salicifolia (Vahl) Nees. It is known to cure epidemic fever, jaundice, cut sputum, stop coughing, and cure hemorrhoids (Chinese medicines). It contains about 25% of oil and trace amounts of alkaloids, calcium phosphate and calcium chloride.

The rhubarb is a perennial herbaceous plant with a height of about 1m, hollow inside, and a leaf length of 25-30cm. The flowers are bloomed in July and August, and the roots are medicinal, and they are used for their taste and taste. They are used for stuffy stuff, bullshit, drooling, stacking, jinga, and ebony.

When a peach ripens around July to August, it picks up the seeds, breaks off the hard seeds and takes out the inside of the peach, I write. Cough, constipation, vomiting, and so on.

It is also called "hagaru". It grows in the mountains. The height is 1.5m and there is a little hair on the whole except flowers. Leaves are alternate phyllotaxis, length 50 ~ 100cm, butterfly 3 ~ 20cm and light brown hairs when young. The small leaf is ovate or oval with sawteeth on the edge. The surface of the leaf is green, the back is white, and there is a small cotyledon on both sides of the petiole. Muscle pain, paraplegia, headache, paralysis of the paralysis is often used.

Cordyceps is also referred to as the grasshopper, and is a word that comes from all the mushrooms of Cordyceps mushrooms. Spiders, cicadas, butterflies, and bees, and gives off fruiting bodies. Red caterpillar fungus, cicadas caterpillar fungus.

It is a deciduous broad-leaved arboreous tree with a height of more than 10m, and the leaves are alternate and oval. In one room, the bark is used as a supplement, as a tonic, to strengthen the cerebrum, and to control the lungs, knee, and mucous membranes. In the private sector, dandruff leaves are used for neuralgia, hypertension, and also by tea.

Mahwah is an evergreen shrub that grows in dry highlands or sandy fields. It is 30 ~ 70cm in height. Stems stand straight and have many branches like horses. There is a lot of nodes and scaly membranes in the nodes (semi-transparent like membrane paper), a pair of leaves run together and the bottom is surrounded by the main stem. The roots are as hard as trees and reddish brown. It has the efficacy of sweating, fever, shinhae, and diuretic, and is used for the treatment of fever and asthma.

Machi-hyeon is also called pork cutlery in Korea, and is used as feed or medicine. This medicinal product is soft, unusual, odorless, mucinous, flavorless, and sour. It has antipyretic, detoxifying and hemostatic effects and is used for bacterial dysentery, boils, hemorrhoids, cervical lymphadenitis, eczema, fever, uterine bleeding, urine discomfort. Antimicrobial activity by pharmacological action, intestinal interactions by intestinal smooth muscle contraction, and diuretic effects were reported.

Rhododendron is an evergreen shrub of the azalea rhododendron of the dicotyledonous plant and grows in the high mountain region. It is 1 ~ 4m in height. The bark is white with ashy. Leaves are alternate but 5 to 7 are gathered at the ends of the branches and are oval or elliptical, and are swollen (leather-like texture). Length 8 ~ 20cm, butterfly 2 ~ 5cm, edges are flat and dry back. It is dark green on the outside and light brown hairs on the back. The petiole is 1 ~ 3cm long. Used as diuretic and tonic.

Mancham is a perennial herbaceous perennial plant of the dicotyledonous plants, and the juice comes out when it is cut. The roots are bellflower shaped and about 30 cm long. Leaves are alternate but short branches are opposite, egg-shaped or oval-shaped, with fine hairs on both sides and white on the back. Leaf length is 1 ~ 5cm, butterfly is 1 ~ 3.5cm, petiole is 2 ~ 3cm long and hairy. It is used as expectorant.

Malt is a grain of barley germinated by the action of moisture, temperature and oxygen on the surface of the barn. It is also used as a raw material for beer brewing and it is also used to prepare microorganism culture media. It contains sugars such as starch and vitamins. Amylase is strong and is used as a nutrient, a digesting agent (diastase etc.), a feed for livestock, and a raw material for producing a saccharide.

Macmun dong grows in a shady area with evergreen trees with monocotyledonous plant lily lilies. Leaves gather from short, coarse rootstocks to form an abandon, and often the root ends grow like peanuts. Stems stand straight and 20 to 50 cm high. Leaves are dark green with linear shape, length 30 ~ 50cm, butterfly 8 ~ 12mm and lower part like leaf sheath. Flowers bloom in May-June, purplish, 3 ~ 5 on the nodes of the inflorescences. Used as anti-inflammatory, tonic, shinhai, expectorant, and cardiotonic.

The quince is a medicinal fruit of the neck and the quince tree, and it tastes and the nature is warm. It is used for muscular deafness, angelic disease, and tsunami.

Akebia quinata Decaisne, or other stem, is a medicine made by cutting the skin and cutting it horizontally. When the bladder gets wet with pus caused by pyelonephritis, cystitis, urethritis, When you have heartburn, red urine, paralyzed pain.

It is a perennial herbaceous plant of the dicotyledonous plant of the dicotyledonous tree. It stands straight and is 0.8 ~ 2m in height. The entire hair is densely grown and grown as a herb. Leaves are alternate phyllotaxis, oval or long oval, with sawtooth on edge, and hairy on backside. The flower blooms in July-August, it is 5 ~ 10cm in diameter, yellow, and one headed flower runs on the axilla. It is used as sweating, diuretic, expectorant, and has a repellent component.

Mui is a dried medicine of ripe berries of Ulmus macrocarpa belonging to the elm family and is also called 姑, 荑 仁 仁, and 楡 荑 荑. It is also used for intestinal hemorrhoids, hemorrhoids, and malaria.

It is a medicinal herb made of root peel of peony. It is a medicinal herb which is caused by hemorrhagic fever, menstrual cramps, bruises, blood clots, nosebleeds, spotting symptoms, tingling symptoms, blood pressure rise, hemorrhage, bruise, It is used for analgesia, boil therapy, appendicitis, etc. and eliminates chest tightness. In addition, pharmacological actions such as analgesia, sedation, antipyretic, anticonvulsant, anti-inflammatory, anti-thrombotic, antiallergic, gastric secretion inhibition, uterine mucosal hyperemia, and antimicrobial action have been reported.

Mint is a perennial herbaceous perennial herbaceous perennial plant of the monocotyledonous plant with monocotyledonous plants. It is also known as Nyomi, Bantarach, Indancho, and Mentha. It grows in wetlands and is 60-100 cm high. The stem has a square cross section and hairs on the surface. The leaves are faced with a leaf with a bag, and the edges are serrated.

The windshield is made of roots and rootstocks of Saposhnikovia divaricata Schiskin (windbreak) and it is a medicinal material which is very important medicine for the treatment of windbreak (wind disease), which means to block wind. The windshield is cylindrical and the lower part is slightly thinner. The outer surface is light brown, and the upper part of the rootstock has dense wrinkles in the form of rounded nodules, and some of the hairy leaves of brown hair are attached. It is effective for all kinds of aphrodisias such as external headache, chills, fever, whole body and sore throat.

It is a perennial herb that grows in a field and is about 30cm in height. Although there is toxicity to the roots, there is the effect of gadam and Jinhae in one room, and it is used for vomiting, diarrhea and vomiting during pregnancy.

Cabbage is a biennial plant of poppy-necked mustard, and the outer leaves are shaped like an inverted egg, with a broad white center vein at the center of the leaf and green or light green. 100 grams of Chinese cabbage contains 33 IU of vitamin A, 100 IU of carotene, 0.05 mg of vitamin B1, 0.05 mg of vitamin B2, 0.5 mg of nicotinic acid, and 40 mg of vitamin C. There is no vitamin A in the white part which is soft white, and there are many in the blue part.

This is the top of Chelidonium majus Linne. Stems with many branches are attached to the opposite leaf, stems are hollow and light brown. The back of the leaf is white and green. Because the whole body comes out with the milk juice, it is called the baby grass and it is called the milk grass. Pharmacological actions include anticonvulsant, intestinal peristalsis and salivation, antitumor, hepatitis, and antimicrobial activity.

In Korea, Baekduong refers to the root of Pulsatilla koreana Nakai or its plants. The outer surface is yellowish brown or brown with irregular vertical wrinkles, the epidermis is easily separated, the yellow neck is exposed, and there is a net-like pattern. The muscular head has white soft hairs and stems and leaf spots. The vagina is firm and easy to fold, and the folded side is flat. Dysentery caused by moist heat, amoebic dysentery, cervical lymphadenitis, hemorrhoids.

The white rice is a medicinal material made of the Cynanchum atratum Bunge or the roots of the same plant, and the thin, long, thin roots are gathered at the short rootstock to form a horse-like ring. It is easy to crumble and the broken surface is white. It becomes a distinction. The white rice consumes the blood of the blood and the body after the postpartum fever or postpartum, and it does not go to the inside and it heals the lonely symptoms, and the sea water, the diuretic, the boil, the sores, the sore throat, Used for bite wound.

Bacillus is a medicinal herb that grows the orchid 's bloom. Its efficacy is a blood stain caused by waste heat, a hemostatic agent used for blood clots due to stomach fever. It is used for surgical diseases such as boils, and makes new flesh. In addition, local bleeding hemostasis, stomach, duodenal therapy, acupuncture, hypertension, and anticancer effects were reported by pharmacological action.

The sandalwood is an evergreen broad-leaved arboreous herbaceous tree with a height of 6 ~ 10m. It has a bright blueish white color and leaves are ovate and egg-shaped. The inside of the tree is yellowish and has a good fragrance and is used for incense, medicines,

Gyeongbyeong is a word from the roots of a paulownia sauce, which is used to cure burns and burns.

Baek Bok-ryeong is the scion of Bokryeong, which is also called Bongsool Byeongryeong. It grows in the place where the pine trees of all over the country are cut. Baek Bok-kwŏn is parasitic on the roots of reeducation, and has taste, boredom, nature, and diuretic effect but not strong. It has been used as a tonic for a long time. It acts on menopause, nausea, heart, nerve, and bladder to see the spleen, remove sputum and stabilize the mind. Pharmacological studies have shown that diuretic action, lowering of blood sugar level, sedation, etc. It is also known that the immune revival function.

The white man is also known as the yellow hinge and grows in grasses or bushes. Roots are strong poisons, but they are used as ginseng and painkillers in one room.

White porcelain refers to seeds of cinnabar. There is an action that stabilizes the mind and body and lubricates the intestine. It is used for border, sperm, huhan, constipation.

The white-tailed reptile is the outpost of the macaque (Oldenlandia diffusa (Willd.) Roxburgh). It is a name given because white flowers bloom and flowers resemble the tongue of a snake. It is also called Baekwunpo because it was firstly collected at Baekwoonsan in Jeollanamdo, Korea. It grows mainly in southern region and Jeju Island. It is used for seawater, tonsillitis and sore throat due to waste heat. It is also used for appendicitis, pelvic inflammation, jaundice hepatitis, dysentery, and also has a detoxifying effect on boils and snakeheads.

It is a perennial plant of the buttercups, which grows in deep mountains and is 45 to 50 cm high. Roots are used for pain, gait, and women's diseases.

Blank paper refers to the roots of gourd, and it is used for headache, back pain, and nausea due to a cold. It is also used as a surgical medicine in the boil.

It is a dried medicinal material which is dried by removing the roots or the juniper of the leaves of the Asteraceae, and has a peculiar smell, taste a little bitterly, chewy and viscous, and the quality is warm. The function of the nose is fragile, and news, malaise is generated, the face is yellow, the stool is diluted, the diarrhea is good, the water is stagnant and the whole body is swollen and helps digestion of water when it is not digested. It is also used for cough, clear sputum, etc. It is also used for cold and limb pain with gastrointestinal disorder.

The bokbunja is a medicinal product made from unripe berries of bokbunja berries of Rosaceae. It is odorless, flavorful, sweet and warm. The kidney function is strengthened and it is used for the 遗精 (遗精), 夢 精 (夢 精), etc. to weaken the vision, lighten the body and darkens the head. It also makes the skin soft and beautiful. Anti-inflammatory, antioxidant and anti-Helicobacter pylori activities have been reported.

Bokyeong is a mushroom of mushroom and mushroom, and it is parasitized in the root of tree such as pine in the ground. Sclerotium (Sclerotium) is 10-30cm in size, rounded or elongated or lumpy. The surface is reddish brown, light brown or blackish brown, lustrous, and sometimes peeled (root skin). The flesh is white and gradually turns violet. It is called Baekbokryeong which is white and Baekbokryeong which is red. Also, it is said that the pine root penetrates in the bamboo grove. All are herbal medicines that are used for tonic, diuretic, sedative, etc. for kidney disease, cystitis, and urethritis.

The daffodil is the medicinal material made of ripe peas of the coconut palm (Areca catechu L .: Bin (檳)) (Korea, China, Japan) The outer surface is yellowish brown with a vertical wrinkle, covered with a coarse fiber layer, with an inner surface of yellow, dark brown, glossy and thin vertical wrinkles. The cross-section is a pale yellowish brown color, and the fiber group looks like a pale brown or dark brown point with a cross-section, while the other is called a low-brine, a bilingual, a bilingual, There are a lot of bamboo dressing and bamboo dressing.

The rich is the root of the root, belonging to the buttercups family, and is also known as Odu. In one room, it is common with temperate excitement, heartbeat, pain, diuretic as 桂枝, bokryeong, licorice, etc. In addition to restoring the extreme decline of metabolic function, it is used for cold, chills, numbness, pain, neuralgia, rheumatoid arthritis.

Leek is a perennial plant of lilies. The stem of the scales has a short rootstock underneath and a black-yellow fiber on the outside. The stem of the scales is used for the stomach stomach, the burn (burn), and the soft plant edible. Seeds are used as a medicinal product of urine because they are from one to the other.

The North Shi Lake is also called 묏 Minari, which grows in the grass and is 40 ~ 70cm high. It contains saponin and fatty oil in its roots and is used as a medicine in the oriental medicine for fever, pain, tonic and respiratory, digestive and circulatory diseases.

The ice sheet is also called the cerebellum and refers to the crystals obtained from the cerebellum. It has directionality and is used for the treatment of stiffness, stiffness, fever, fever, and sore throat.

The apple rock refers to the fiber and the vascular fiber of the reticulum among the fruit of the Luffa cylindrica Roemer. This medicinal product has the name of yarn and lacuna because the pulp becomes fibrous when it is ripe. Its shape is slightly curved from long cylindrical to long, and both ends are relatively thin. Outer surface is white or yellowish white, and several layers of reticular fibers are crossed and appear like a net. This medicine is lightweight, quality and not broken. There are 3 ovary chambers with three large cavities, with some black seeds remaining inside. It also originated from the southern part of the country, and it was called "Obi" in the meaning of the southern barbarian. Edema of the arthritis, inflammation of the redness, communication of the pain, and inhibition of skin bacterial infection were reported.

It is a medicinal product made from roots of Adenophora triphylla var. Japonica Hara or a plant of the same species as South Korea. The ginseng is ginseng, ginseng, dansung, (5), which are all different in shape, but the treatment is similar. The name "Sansan" is white, and it is a name that is well known and adhered to in the sand. Its appearance is spindle-shaped, long conical, bent, and occasionally with roots. There is a rhizome with horizontal wrinkles on top. The roots are light and easy to bend, and the folded side is milky white with many gaps. The pharmacological effects of gadam work, antimicrobial action, hemolytic action, and cardiac action have been reported.

Wild ginseng is a kind of wild ginseng that grows in deep mountains. Its taste is slightly sweet, and its quality is slightly warm. It has the effect of going into the rain, menopause and seeing the joy.

It is named after Crataegus pinnatifida Bunge var. Typica Schneider and the ripe berries of the same plants. Because the shape of the mountain temple is similar to the red jujube, it is called the red japanese. Cardiovascular function, blood circulation improving action, blood pressure lowering action have been reported.

Cornus syrup is a fruit of the seedling tree which is a deciduous tree of the debris. It is an elliptical nucleus and it is green at first, but it ripens red from August to October. The pulp contains glycosides such as cornin, morroniside, loganin, tannin and saponin, and organic acids such as wine, malic and tartaric acid. It also contains vitamin A and a large amount of sugar. It has been used as a medicinal product for headache, tinnitus, sea water, fever and menstrual overcrection. It is also used for folk remedies such as sweat and enuresis.

Acacia is a tuberous root of Disocorea japonica or Disocorea batatas belonging to the family Disocoreaceae and is collected and dried between the autumn and winter solstices. It is white or yellowish brown, and the inside is hard with keratin (granular) or gelatinized (keratin).

Sanjo is a medicinal product made from seeds of Chikyu Daishi. It is used for nervousness, insomnia, forgetfulness, cold sweat, and strengthens the stomach and is effective for anemia. Pharmacological effects were sedation, hypnosis, hypotension, analgesic, hypothermia, antioxidant, immune hyperactivity, and uterine stimulation.

Woodchuck is a fruit of a woodchuck tree and is used as a medicine for fever, hemostasis, diuretic.

Saururus chinensis is a perennial plant of the dicotyledonous peppercorn Saururus chinensis, which grows in wetlands. Root stalk is white and sits side by side in mud. The stem is 50-100 cm high. Leaves are alternate ovate ovate, 5-15cm long, pointed end, heart shaped, 5-7 veins, flat margin. The surface of the leaf is green and the back is light white, but the surface of the leaves is 2-3 in the upper part of the stem. The petiole is 1 ~ 5cm long and the lower part is wide and covers the stem. It is used when the body is swollen and the urine does not come out easily. It is also used for each jaundice, jaundice and hepatitis.

It is a perennial plant of the dicotyledonous flower of the dicotyledon. It has a long stem, long stem, and a fragrance. The stem is straight and the upper part is divided into several branches and the height is 30 ~ 100cm. Leaves from the roots are dried out when they bloom. The leaves on the stem are alternate, the leaves on the bottom of the stem are deeply split into quartz, the cracks are 3-5 pieces, the elliptical shape or the long oval shape with the egg being inverted, the surface is shiny, There are thorns like thorns and petiole length is 3 ~ 8cm. The leaves on the upper part of the stem are not split and there are few petiole. Root stems are used as a medicinal product called 蒼朮. They are effective for sweating, diuretic, analgesic, and dryness, and are used for anorexia, indigestion, gastroenteritis and cold.

It is a medicinal herb that dried leaves, stems and branches of Mulberry Mistletoe (Loranthus parasticus Merr.) Or mistletoe (Viscum album L. var. Coloratum Ohwi). It has a function to lower blood pressure, And the kidney (肝 肾) to see the bones and muscles to strengthen the early anxiety is used.

It is a medicinal substance made from the root shell of mulberry or perennial plant, and it is a diuretic to treat seawater and asthma caused by waste heat. It is used for acute pyelonephritis, weakness edema, hypotensive effect, and also for nosebleed and blood. It is also used for epidemic hepatitis. The pharmacological action was reported to be Jinhae, diuretic, hypotension, sedation, analgesia, fever, epidermal and antimicrobial effects.

Sangsan is a deciduous shrub with mulberry leaves and mulberry trees. Its height is 1.5 ~ 3m, the bark is grayish brown and there are some hairs on young branches. Leaves are alternate, two on each side, 5 ~ 13cm long elliptical or egg-shaped inverted, pointed end, round bottom, flat edge or wavy sawtooth. The surface of the leaf is yellowish green, shiny, with a distinctive smell, and petiole is short. The roots are used as herbal medicine called goat (goat), and it treats seawater, fever and sore throat caused by cold, and it is effective for athlete's joint arthritis, dysentery, boil and school.

Morus alba (Morus alba L.) is a medicinal herb that leaves the leaves of related plants. The mulberry, which means mulberry, is said to be a combination of medicines and tree trees that represent the holy chieftain of the east. This is because the mulberry tree, the tree that the silkworms eat, has the same efficacy as the chinese herb, so it is used to distinguish the two. The upper leaves are used for fever, headache, eye congestion, seawater, dry eye, skin rash.

The superior is also called Hongdu. Pods are poisonous because they have abrin and are used as arrow poison. Leaves contain glycyrrhizin, which is sweetened like licorice, so it is made into a drink for a month.

Root stems are dried and used as spices for bread, cookies, curry, sauces, pickles, etc., peeled, boiled, put in syrup, cut into ginger, and made with ginger. In oriental medicine, dried roots are used as medicines for health (dryness), which is effective for digestion, vomiting and diarrhea, promotes blood circulation, has anti-inflammatory and analgesic effects.

Seokchangpo is a perennial herb that grows in the mountains and fields. Root stalks are sideways, and beard roots come out from the nodule. In the ground, the nodis is long, but the nods are short and green. Leaves are clustered in rootstock, 30 ~ 50cm in length, streaked, veined, and pointed. The lower part of the outer leaf is wrapped around the lower part of the inner leaf and arranged in 2 rows. Rhizomes are used as analgesics, sedatives, and nasal preparations, and in public baths.

Seonghakcho is a perennial plant of Rosaceae. It is also called as a strawberry herb. It is called Seongjakcho or Yongaekcho which dried the outpost before flowering in summer from autumn to autumn. Hematemesis, hemorrhage, hemorrhoids, and cancer.

It is a plant of Lamiaceae and is a plant. It is flavored with roots of Salvia plebeian R.Br. It also has the ability to calm the swelling and is known to be used to treat hematemesis, nonhemorrhage, swelling, bruising, and poisoning.

Seeshin is a medicinal herb that has dried the roots of the perennial plants Minxuri and Luciola, belonging to the Rhesus Vines, and is also known as the root of the Lucius. Between spring and summer, roots are picked up, washed thoroughly in water, and dried in the shade. My head aches from colds or whites, my nose is blocked, my fever is aching, my sputum is coughing and I use it when I catch my breath. It can be used for laryngitis, rhinitis, bronchitis.

Leaflet is an annual plant of Lamiaceae and its height is 30 ~ 100cm. Leaves are opposite to each other, egg-shaped, sawtooth on edge. From August to September, a light purple flower blooms on the tip of the leaf axilla or stem, and the fruit forms a round shape. Leaves and stems are used as medicines, and young leaves and seeds are edible. It is also known as a charger, a charger, and a seed device.

Pine is an evergreen needlework tree of the pine tree. Each leaf is used as an indigestion or a tonic, flower is used as a dysentery, and rice gin is used as a raw material of plaster.

It uses root of Jasmine floridum Bge., A plant of the ash tree, and is used for wound healing.

It is an annual crop of buttercups and is also called a dill. It gives flowers, leaves, stems and seeds as herbs because it gives a unique fragrance throughout the giving. Seeds are good for digestion, wakefulness, calming, hypnotic effect, good for removing bad breath and for preventing arteriosclerosis, and can be used as a bed for sleeping.

Inheritance seeds are seeds of medicinal plants and are used as diuretics, laxatives, edema, ascites, food poisoning, and the like. Inherited seeds are toxic, so be careful.

The genus is a perennial herbaceous perennial plant with a monocotyledonous plant, a monocotyledonous plant, and grows in the mountainous region. The stem is straight and about 1m high, with fine hairs all over, and the roots are bushy, with five coarse root roots. Leaves are opposite to each other, with long petiole and egg shaped like a heart. There are regular, dull serrations on the edges of the leaves and fine hairs on the back. The coarse roots are used for the gingko (gingko) and women's diseases.

Pine mushroom is an edible mushroom of the typical pine mushroom which has a unique fragrance and taste that occurs on the pine forest land. Generally, pine mushroom occurs in 20-60 year old pine forest, and Pine mushroom is a symbiotic bacterium that forms mycorrhiza on the root of pine tree.

Horseback riding is a perennial herbaceous plant of the buttercups and is also known as an endangered species. In one room, roots are called horse riding, and are used as antipyretics and antidotes. It was reported that when used with a lot of heat due to a cold, sweating and fever were reduced.

Seoho is a perennial herbaceous herbaceous perennial herbaceous herbaceous herbaceous herbaceous plant. The root contains saponin and fatty oil, and it is used as a medicinal herbal medicine for the fever, pain, tonic, respiratory, digestive and circulatory diseases.

A new song is called a flesh song, usually a mixture of six different medicinal products. It has the function of strengthening the function of the fire extinguisher and helping the digestion, and the action of relaxing the inside. When you feel sick, when your chest is stuffy, when you have vomiting and diarrhea, when you are sick due to postpartum ejaculation. Pharmacological experiments have shown that there is a tonic action.

It is a semi-shrub of the rosemary bean with the dicotyledonous plant roots, and is also known as the 牛 牛, hozyaza, horsetail, and ishuri. It is used for the lack of yang, anorexia, premature ejaculation, cough, pertussis, and snake bite. It has been reported that pharmacological action, coughing action, gadam action, flatulence action, action on the uterus, and antibacterial action.

Hachikyo is a stem of a dwarf perennial plant, which is a vine-like perennial plant of the dicotyledonous plant, and is effective for Jinhae, Gadam, and arthritis.

Horseshoe is the underside of the flowering period of the strains of Saururus chinensis. Hwasungcho is excellent for diarrhea and drainage. It is used for coughing caused by lung abscesses, pneumonia, pneumonia, acute chronic periodontitis, enteritis, urinary tract infections, boils, and is used when there is a lot of heat and urine. Antimicrobial activity, immune enhancement, antiinflammatory, diuretic, and calming action have been reported by pharmacological actions.

Associated school is the fruit of the forsythia or affiliated school of the aspen. It is used in fever and mental complaints. It is used for boils, rashes, appendicitis, lung abscesses, lymphadenitis, sore throat, diuretic, anti-inflammatory effect. Antimicrobial action, anti-inflammatory action, blood pressure lowering, hemostatic action, liver treatment action, fever, swelling, diuretic action were reported by pharmacological action.

The rice is the fruit of the lotus. The rice is used for women's diseases.

Pineal gland is a seed of lotus seed, which is a herb that has been peeled off and dried. It has been widely used since it has been helping the sick from old days, spirited and cheerful and taking a long time to become lighter, aged, not hungry and longevity. The pharmacological action was reported to suppress the nasal cancer and the throat.

The area is native to southern China and is often cultivated as a fruit tree. The fruit is round, about 3cm in diameter, and looks like a turtle's back with a protuberance on the outside. The flesh is sweet and has a unique scent and eats freely. It is said to be the king of fruit in southern China.

The spring is called poppy flower, and it is used for emergency disease by separating the fruit and plant of poppy in private. When opium is smoked with cigarette, it feels blurred by being in anesthesia state, and when it becomes addictive, it shows addiction phenomenon and even death. Seeds contain 45-50% fat and are used for edible or industrial purposes and have no anesthetic components.

Ganoderma is semicircular, elongated, or fan-shaped mushroom. It is used for the treatment of nervous breakdown, heart disease, hypertension, various carcinomas because it has the effect of gangjang, Jinhae, and exenteration. This mushroom is wrapped in solid husks and has varnish like varnish, and it is said that it is used as a Chinese medicine material and it is used for decorative purposes.

Oduto is a root of the root which belongs to the buttercups of the buttercups and is also called as a child. In one room, it is common with temperate excitement, heartbeat, pain, diuretic as 桂枝, bokryeong, licorice, etc. In addition to restoring the extreme decline of metabolic function, it is used for cold, chills, numbness, pain, neuralgia, rheumatoid arthritis.

Ogphi refers to the roots, stems, and branches of the rootstock of Orgalaceae, or the genus Orthoptera. Ogapi is used to strengthen the tendons and bones by showing the energy of the liver and kidneys. It is used for limb paralysis, burning, softness symptoms of the waist and knee, weakness, numbness, fractures, bruises and edema. The pharmacological actions were immune enhancement, antioxidant, anti-fatigue, anti-hypertension, anti-irritation, endocrine control, blood pressure control, anti-radioactivity and detoxification.

Omija is the fruit of a Japanese oak tree, and it is a ball with a deep red color with a diameter of about 1cm. It contains 1-2 drops of red juice and reddish brown seeds. There are five flavors of sweetness, sourness, bitter taste, salty taste and spicy taste, among which the sour taste is strong. It contains ingredients such as thiazide, thymidine, citrulline, malic acid, and citric acid, which strengthens the heart, lowers the blood pressure, increases immunity, and is used as a tonic. It strengthens the pulmonary function, and it helps to cure the cough and thirst by the deep sea bream and the geodam function.

It is a wormhole formed by the parasitism on the leaf of a rhus cotyledon (Rhododendron), and it is like an irregular pouch shape and resembles a human ear shape. The inside is empty, and the taste is very good. In one room, it has the effect of convergence, hemostasis, detoxification, and antibacterial, and prescribes diarrhea, desquamation, gastric ulcer, duodenal ulcer, diarrhea, hereditary stool, hematocrit, hematuria and stomatitis. It contains 50-60% of tannin component and becomes raw material of tannin, hair dye and ink including tannin.

Otsu-yu is a deciduous broad-leaved arboreous tree of the dicotyledonous foliage of the dicotyledonous foliage. It is called a fenugreek or fenugreek, ) And diuretics (diuretics).

It is a root of dried tengtaek oak, which is used for the treatment of throat, fever, and urine.

It is a kind of corn beard in an oriental medicine and it is used for the treatment of diseases such as diabetes, blood pressure, cholesterol and other adult diseases, diuretic, acute gastritis, nephritis, pregnancy edema, swelling, fever, hemorrhage, stone, pleurisy, ascites, cystitis, Cholangitis, cirrhosis, arthritis, etc.

It refers to a medicinal material that is dried on the roots of Jade gruel, and has the effect of cheongryeol (淸 熱) and yin (陰阴).

Wassong is a perennial plant of perennials with dicotyledonous rosewood and perennials. It grows on rocks in the mountains and near rocks. The whole paste is used as a tonic and the leaves are used when squeezed juice and bitten or burned by insects. It has excellent anticancer effect and is effective for fever, hemostasis, hepatitis, eczema, dysentery, malignant tumor, burn.

Yonggye is an annual crop of twig dwarf plants, monocotyledonous plants, and tree branches. It is also known as kamatsu, camomile, and camphor. In one room, the whole paste is dried and dried in summer and fall, and is prescribed for cold, chronic bronchitis, nephritis, hypertension, jaundice, swelling and cancer. In the private sector, it is used to spread the disease, to attach it to a disease or wound, or to drench the affected area.

It is used for jaundice, dysentery, itching of the genitals, itching of the genitals, itching of the genitals, epilepsy, eczema, etc. It is blended with the head and neck spasm due to high fever, Write down the symptoms you can not hear. The pharmacological action promotes the protection of liver function and promotes bile secretion, and a relatively strong inhibitory effect on P. aeruginosa, degenerative bacilli, S. pneumoniae and Staphylococcus aureus has been reported.

Ryeonggak refers to the seeds of the lanterns of the family tree. It is sticky while the texture is soft, has a unique flavor and is used as a sake dish. In addition, Yongsan meat is so thoughtful that it can be used to play with irregular heartbeats, amnesia, insomnia, indigestion, and dilute stools. When you can not control your anxiety, anemia, boredom, sweat after a disease, when postpartum hemorrhagic fever is weak and swelling occurs. Pharmacological actions include suppression of anaerosis, tonic action, antioxidative action, and immune function activation action.

Wussle refers to the root of the stump or spine of the spikelets. This medicine has little odor and is mucoid. The taste is a little bit spicy, and the quality is flat without any bias. If you use raw whiskey, you can eliminate the ejaculation and boils, and if you grind it, you will see the liver and the gods and strengthen the muscles and skeleton. It removes eosinophilia, and it is used for physiological impoverishment, postpartum abdominal pain. It replenishes bone marrow, it is used for arthritis with good sound, and it treats the mouth and tongue rash caused by the diarrhea. In addition, pharmacological actions such as uterine stimulation, cholesterol lowering, diuretic action, hypoglycemic action, and liver function improvement have been reported.

It is a perennial plant with a dicotyledonous perennial herbaceous plant, and its roots are called roots, and it is written as expectorant, tonic, and kangjeongje.

Wonhwa refers to the bud of red bean flowering tree in the red bean flowering plant, and it is called the gohsu (去 水) and two currency (heading flower) in another name. The Korean Won is used for water species, which are kept in asthma, seawater, and flank. In addition, only the abdominal cavity, boils, head rash, urine, feces can not be used for symptoms that do not work well. Increased pharyngeal activity, inhibition of intestinal motility and uterine motion, and insecticidal activity were reported.

Other names are called as evening primrose, Yaingya (curry), and moonbeam (lower), and the roots are used as medicines. Depending on the disease, leaves are also used. In the private sector, oil is used for diabetes do. It is effective for diarrhea, hypertension and obesity. It inhibits excessive accumulation of lipid components such as cholesterol, and is applied to hyperlipemia and the like.

It is also known as flower cloak, and the roots are called gyeryeon, and it is used for gout, arthritis, jaundice, tetanus.

It is effective for gastric ulcer, duodenal ulcer, small intestine ulcer, colonic ulcer, edema, species, stomach cancer, rectal cancer, uterine cancer, diuretic, sinusitis, rhinitis, swelling, swelling and swelling of elm bark.

Rapeseed is also known as flatland. Seed contains 38 ~ 45% of oil. It is consumed 15 ~ 20% of soluble nitrogen and 20% of protein, followed by soybean oil. I write. The flower is a herbaceous plant, and the fatty oil separated from the seed is used as a solvent for the ointment base agent, oily injection oil, or as a lubricant for the machine.

It is a medicinal substance made by using the meat scale of a plant for breeding or other similar plants of a hereditary herb, and has a characteristic odor, flavor, sweetness, texture and a little warmth. It is used for constipation which is caused by dryness of bowel, constipation which is caused by dryness of the intestines, low back pain of the Shinyang tribe, soft weakness of the leg, tinnitus, fatigue, oil well, unferment, infertility, lower abdomen, hemorrhage, sweating and constipation. In addition, pharmacological actions have been reported to lower blood pressure, promote salivation, and improve respiratory paralysis.

Shi Ho refers to the roots of the pine nuts and spices, has no odor, is ary, has a sweet taste, and is slightly cold. Fever, fever due to overwork, cold sweats, pediatric fever, and abdominal distension. The pharmacological action has been reported to prevent atherosclerosis, to prevent cholesterol accumulation, to heal, and to make salivation.

Myeonggokgwa is the ground part of Leptospermi radix or other related plants. It is used for erectile dysfunction, erythema, poor circulation of the uterus, poor circulation of the stomach, paralysis of the skin, numbness, forgetfulness, numbness, weakness of the waist and knee, hypertension and polio. The pharmacological effects of the stimulation of semen secretion, blood pressure, coronary artery blood flow, blood sugar lowering, cholesterol lowering, immune function enhancement, Jinhae, genomes, pyeongcheon, sedation, .

Uiin refers to seeds that have removed the seed coat of rice paddy rice. It is used for various symptoms such as diarrhea, diarrhea, edible stomach, etc. It can also be used for limb paralysis, pain, gingivitis and myalgia, fever, drainage and appendicitis. The pharmacological action was reported to be anti-cancer, suppression of skeletal muscle contraction, intestinal uterine suppression, sedation, pain relief, and fever.

The motherwort is a medicinal plant which dried the ground part when the flower of motherwort and motherwort bloomed. Motherwort, amenorrhea, menstrual pain, poor postpartum uterine contractions and bleeding, abdominal pain when there is blood 瘀 blood (瘀血) and helps the contraction of the uterus. It is used when the body is swollen and has eczema, itching, boils, etc. Pharmacological actions have been reported such as uterine stimulation, thrombolytic action, cardiac and coronary blood flow enhancement, respiratory stimulation, diuretic action, and skin fungicide inhibition.

Raw jin is the fruit of raw rice with ginger. It is used when the urine is frequent due to the abdominal bloating due to weakness of the abdomen, weak urine due to weakness of the abdomen, symptoms of seeing the faeces without power, childhood nocturnal enema, uterine bleeding during pregnancy, Pharmacological actions have been reported to increase cardiac contractility, to inhibit multiple cancer cells, and to increase contractility of the ileum.

Ginseng is a perennial plant of the dicotyledonous plant Araliaceae. Its roots are medicinal. It is called ginseng because its shape is human. Ginseng has long been referred to as an ophiolite, an aphrodisiac (益气), and a shining god (经 명).

Incineration refers to a medicinal plant that has dried the ground part of the matsugi (matsutake mushroom). It is used for the symptoms of jaundice caused by moist heat, such as acute hepatitis, fumes, whole body yellow, red urine and few symptoms. It is also used for chronic hepatitis, hepatitis, liver cancer, cholecystitis, and gallbladder stones. It is also used for the symptom of burning of the skin due to skin diseases such as eczema, omnis, ringworm, rubella. The effect of pharmacological action on bile secretion, antipyretic action, diuretic action, antimicrobial action and inhibition effect on experimental carcinoma cells were reported.

It is also called "Angelica gigas", "Angelica gigas", "Angelica gigas", and "Angelica gigantea". It grows well on the beaches (cottages). The roots of matured Angelicae have been used as medicines because they are idiopathic. They have immune function and are used for anticancer drugs. They are used for anemia, menstrual irregularities, jasmine cold pain, body pain, gangja. Pharmacological action has been reported to lower blood pressure and diuretic action.

One-leaf weevil is a generic name for a clownfish, and it has the efficacy of active blood, tsuki, healthy spleen, and 益 神. Treatment of back pain, limb paralysis, dysmenorrhea, rash, facial nerve paralysis and sequelae of polio due to rheumatism.

The Ilcheon Palace is a perennial herbaceous plant with a mountain type, and is also called the 芎 芎 芎 芎 芎., It is effective for analgesia, astigmatism, bubbles, and blood clots.

Jawan refers to the roots of asteraceae, has a peculiar smell, is ary, has a little taste, and has a temperate character. Jawan softens the lungs and treats seawater, sputum, asthma, wings, and pyeongcheon, especially old sea water and sputum. Sore throat, and acute respiratory tract infections. The pharmacological action of chinhae, germane, antibacterial, and anti-cancer has been reported.

It is a mushroom that grows on the branches that spread out over the water of a lake, a nail, a swamp.

Peony is a word that comes from a perennial herb with a buttercup butterfly. It is cultivated for ornamental purposes in a garden with large and beautiful flowers. Peanuts, peanuts, peanuts, peanuts, and peanuts. It tastes good and is a bit cold. It has a haemorrhagic effect and eliminates eosinophilia. It is used for fever, bleeding, swelling, bruising.

It is a perennial plant of perennials, which is also known as 沙 蔘, beetle, and jenny. In one room, the root is called savian, and it is used as Jinhae, Gadam, Fever, Tang, and Drainage.

It is a horseshoe from the skin of the root of a leather tree, and it is effective for the symptom that the blood is mixed in the fever, the diarrhea and the feces.

It is a mushroom of mushroom and mushroom and is used as a diuretic in oriental medicine.

It is a medicinal substance made by removing the outer layer with sclerot of the bamboo grove with the stinking stool which is parasitized on the pine root. The outer surface is cut off with a knife to a suitable size and dried in the sun. Byeongryeo can not see the urine, swelling of the abdomen and whole body, seaweed, vomiting, diarrhea when there is a forgetfulness caused by neurosis, oil well, and also used for heart swelling. The pharmacological effects of diuretic, insecticidal action, intestinal relaxation, prevention of ulcers, hypoglycemic action, increased cardiac contractility, immune enhancement, antitumor action, etc. have been reported.

The enemy seaweed refers to the medicinal material that dried the roots of red mockery. Red roots are cut or cut in autumn, dried and then dried to protect the intestines and stop diarrhea.

Red cabbage is a kind of cabbage belonging to the cruciferous plant. It is one of the representative health vegetables with the effects of stomach ulcer, anti-aging, and restoration of liver function. Because it is a pretty color, it is used as a decoration for salad and so on, and it is also used as a sprout oil vegetable. Fructose, glucose, vegetable protein lysine and vitamin C are more nutritious than white cabbage. In addition, vitamin U is abundant in the stomach ulcer is effective, preventing aging, prevention of mercury poisoning, and liver function, such as the role of selenium (selenium) is also rich in representative health vegetables. However, people who are cold and diarrhea often do not eat a lot.

This medicine is a kind of peony.

Chungho is a perennial herbaceous perennial plant with a height of about 1m, branches are split, and leaves have long petiole and split into feathers. In one room, the roots of body herbs are used, and they are used for headache, relieving, and dipping.

The bloom of the hole was removed from the twigs of the twig tree, which is the deciduous tree of the twig tree. It has the efficacy of gangjang, giant wind, and Jinhae. It treats weakness of the body, mysterious colic, customs dandruff, seawater and white hair.

Cloves are also called cloves and are said to be good for appetite promotion because they are tasteless.

Sculpture, also known as chow chow, refers to the fruit of the main tree of soybeans. Chow Taijak has a strong gangrene effect and is used for pulmonary tuberculosis, lung abscess, chronic bronchitis. It is also used for spiritual bliss, insomnia, and palsy caused by stroke, and it is also used for boils, skin ulcers, and constipation. Pharmacological actions were gastric mucosal stimulation, stimulation of mucous secretion in the respiratory tract, antimicrobial action, and central nerve palsy.

The sculptor refers to the thorns of the main tree with beans. The sculptor is used for boils because it has strong drainage and anti-inflammatory action, and it releases the skin poisoning. Pharmacological action of acute tonsillitis, fever and inflammation has been reported.

The bamboo is a bamboo of the alopecia plant.

Jong Yong is a medicinal herb that is used for breeding or for breeding or other related plants. It is used for constipation which is caused by dryness of bowel, constipation which is caused by dryness of the intestines, low back pain of the Shinyang tribe, soft weakness of the leg, tinnitus, fatigue, oil well, unferment, infertility, lower abdomen, hemorrhage, sweating and constipation. Pharmacological actions have been reported to lower blood pressure, promote salivation, and improve respiratory paralysis.

It is a word from one side to the thin scabbard of a scabbard. It has the effect of stopping the fever, stopping the gag, cutting the follicle and stabilizing the fetus.

Gigobia refers to a medicinal plant that has dried the roots of Gugija or other plants. It is used for sweating, seawater, asthma, hemorrhage, nosebleeds, hemorrhage, hyperglycemia, hypertension, neuralgia, headache, shoulder pain, muscle pain, back pain, weakness of the back and knee. The pharmacological action of the cardiovascular system, blood pressure lowering action, hypoglycemic action was reported.

The Earth's neck is also called the earth's thorn, and refers to the stem skin of the horned tree. The earth's throat has been reported to help blood circulation, release muscles, and protect the liver from pharmacological action.

Gymnospermum is a monocotyledonous plant lily, which contains asponin and salsapokinin which can be used as a drug ingredient in rootstock. Root stems are used as medicines in herbal medicine. They are used as antipyretics, and have been reported to be effective for chronic bronchitis and diabetes.

The branch is the seed of a year - old grass of the mackerel, also called the great or expensive. Branchers are used as a tonic and diuretic, and are reported to be used as medicines for hyperthyroidism and atopic symptoms.

It is the fruit of the tangerine tree, which is the fruit of the tangerine tree. The stomach is stagnant, and the chest and the stomach are swollen, swollen, chest tight and pressed, sore, edema, indigestion and constipation. . The pharmacological actions were contraction of the uterus, gastrointestinal motility, coronary action, and diuretic action.

Jiyu is used as diarrhea, colitis, hemorrhage, malaria, burns, and is especially used for stopping blood from various bleeding due to strong hemostatic effect.

Gwanghwang is a plant with ginseng, and it is said that the raw material of roots is raw persimmon, dried persimmon leaves, steamed persimmon leaves and dried persimmon leaves. It is used for the weakness, weakness, weakness, weakness of the child, dementia, premature ejaculation, and erectile dysfunction, and it is used for the fragile constitution, hematemesis, nosebleed, uterine bleeding, menstrual impurity and constipation. It has been reported that thirst and throat caused by fever inside the organ are effective and stop the blood and nosebleeds.

Jinbeom is used as a medicinal herbaceous plant in oriental medicine, and it is reported that it is used when it is used as a medicinal product when it is dried and used as a medicinal product. It is used when there is a strong wind, pain, diuretic effect, arthritis, muscle and bones spasms, jaundice and urine.

Genie Ogphi refers to a kind of Ogphi. It removes the customs out and makes the meridian communicate well. It has the analgesic effect and strengthens the functions of the liver and kidneys inside and strengthens the muscles and bones.

Pearl grass is an annual plant of grass and grass, and other names are fox beads, sunny lungs, crucifix pearls, yin yang suk, It is also called persimmon, cherry blossom, cherry blossom, mountain sculpture, leaf scarlet, regret, young cherry. It is known that pearl juice has the effect of brightening chronic hepatitis, nephritis, enteritis, dysentery and eyes.

Dandelion refers to medicinal use of the fruit bark of a citrus tree. The dermis cleanses the gums and strengthens the function of the fat, treating only the abdominal cavity, trimming, vomiting, nausea, indigestion, sluggishness, lingering symptoms, and thin feces. Seawater, sputum and diuretic action. Pharmacological action has been reported to cause the digestive tract stimulation, digestion promotion, geomorphic, anti-ulcer, antidiarrheal secretion, hypertension, elevated blood pressure, antiallergic, bile secretion promotion, uterine smooth muscle suppression,

Chae - ee is a word from plant to plant seedlings. The tea electrons are used to help urinate, control diarrhea, clear the eyes and stop coughing.

The cherry tree is the fruit of a chrysanthemum. It is used for the treatment of sinusitis, rhinitis, headache, fever, cough, paralysis of the extremities, irritability, irritation of the skin and otitis media. The pharmacological effects were toxic reactions to essential oils and alkaloids, blood glucose lowering, prevention of leukocyte reduction, vasopressors, and cardiac inhibition.

In the oriental herb, it is used for calming, pain, and tonic for headache, anemia, and women's diseases.

Chunma is a perennial plant of monocotyledonous plant orchid and orchidaceae, and uses outpost for tonic, nervous breakdown, dizziness and headache.

Chunmun-dong is a lily of the valley, edible, and its roots are used as deep-sea, diuretic, and tonic. It has been reported that the body can not be used for people with diarrhea due to poor health.

It is also called "sancho" in other names. It is a phytoncule made by removing the seeds as much as possible as a pea of a Japanese peony or a peacock of the hornblende. It is used for abdominal pain caused by cold weather of the abdomen, diarrhea and toothache, asthma, low back pain, insecticidal action, itching, ringing itching, scrotum eczema. Local anesthesia, intestinal interactions, and antimicrobial effects were reported as pharmacological actions.

It is also called a frog's claw. It grows at the foot of a mountain, and its height is 20 ~ 30cm. In one room, urine discomfort, urinary stone, lymphatic inflammation, hemorrhoids, uterine inflammation, gonorrhea, gyeonggi, epilepsy, etc. are prescribed. In folk remedies, when you are bitten by a snake or insect, it is stuck on your wound.

It is also called Dracena, and about 50 species are distributed in the tropics. The leaf is a parallel vein, it is 革 質, it is a blade which is like a knife or a wide oval shape. It is 30 ~ 50cm long, 6 ~ 10cm wide and has petiole. The stems stand upright in the woody form, and at the end of the stem, there are small flower buds with 6 petals.

It is also used for the treatment of coronary artery disease caused by the blood ejaculation, and because of the heat of the lungs. It is used to calm the cough and asthma, lower the fever of blood, and to rash with boils and skin tear.

It is a perennial herbaceous plant of the common herbaceous herbaceous herbaceous herbaceous plant of the Chinese tsunami (Tianyang) in China. The stem is straight and the root of the stem is wrapped in scales. Cheonan Yoon is especially effective in helping men's rejuvenation and has a great efficacy in various gynecological diseases, cold diseases, kidneys, arthritis, diabetes, menstrual and uterine circulation,

Chunghwa is also referred to as 괄 루 근 root, and refers to the roots of the naked naked and the yellow naked. Treating petechiae, boils, and nausea when heat causes damage to the juice. It mainly produces lungs and stomach fever, so it helps to quench thirst and softens the body. The pharmacologic action of these agents has been reported to inhibit malignant glandular cells, epithelial cell carcinoma, uterine smooth muscle excitement, hepatocarcinogenesis, hypoglycemia, and bacillary action.

Chung Ho is said to be the highest among the horses that refer to mugwort, but only Chung Ho is called Ho (蒿). Cheongho treats the nausea, headache, and vomiting caused by schizophrenia and summer heat by turning off the hemorrhoids, tingling the uvula due to undergrowth, treating fever and symptoms of summer fever. It also makes the face look better and darkens the white hair. Pharmacological actions have been reported to inhibit pandemic, to inhibit hepatic damage, to lower blood pressure, to paracetamol, to inhibit skin fungi, to calmness, to genomes, to asthma, to bile secretion,

The excess is ginger and the plant uses excess fruit in Korea. Excessive warms and removes wetness, abdominal pain, abdominal pain, nausea, vomiting, diarrhea.

It is a medicinal substance made from the roots of the root of the rootstock or the root of the root of the rootstock. Headache, abdominal pain, boils, half-headedness, greeting Buddhism, Guan Wasa. It is applied to abdominal pain caused by the cold of the stomach, treating the paralysis symptom caused by customs, insomnia, rheumatoid arthritis, neuralgia, back pain and tetanus. Pharmacological action, analgesic, sedative, anti-inflammation, local dermatological relief, and large doses of cardiac exercise excitement was reported.

Gardenia refers to the fruit of gardenia, an evergreen shrub of madder. In one room, it is reported that it is used for the treatment of insomnia and jaundice, and has the effect of inflammation, hemostasis and diuretic.

The blue box refers to the seeds of the ginseng with the ginseng, and the ginseng box is used for the symptom of redness, white stomach, tears, relieving the light, hypertension and headache. It is used for ophthalmic diseases by pharmacological action and is applied to skin irritation.

It is used for the symptom of red bladder, lower abdominal circulation, insomnia, hemorrhage, uterine hemorrhage, burns and redness of the nose. It has been reported that pharmacological action has an effect on malaria.

It is an evergreen tree with the red bean flower bloom. It has a calming effect, a dryness, a ventilating action, and is effective in digestion failure, anorexia, vomiting, bronchial asthma, premature ejaculation,

The tacrine refers to the ground part before the blooming of the flower with the bud of the moth. Takan is used for amenorrhea caused by hemorrhage, menstrual pain, postpartum abdominal pain, bruise, boil, liver dysfunction and postpartum voiding. Among the medicines that release the eosinophil, it has a merit that it does not damage the periodic, so it is widely applied to gynecology. Radiation has been reported as a pharmacological action.

Taxa was also reported to be called keitae, and rootstock was reported to be used as a medicine in diuretic, species, and gonorrhea in one room.

Tangerine is a tangerine fruit that is fragrant and medicinal.

Satong Bokryeong refers to the roots of Chongmaidae (chestnut tree). It is said to be effective for constipation, syphilis, gonorrhea, typhoid, malaria, chronic dermatitis, mercury poisoning, cold and neuralgia.

It is a seed of a young plant which is an annual plant belonging to the filamentous fungus. It is known as a medicine that protects the liver and kidneys, brightens the eyes, helps the kidneys and strengthens the kidney function. It is effective for men with sexual intercourse due to fragility of the kidneys, when semen flows by itself, and by the mungjeong (夢 精). It strengthens the bones, strengthens the back strength, and weakens the kidneys and heals back and knees and sore. It has also been reported to be effective in the treatment of diabetes, as well as in the treatment of illness and diarrhea that can not see urine and urine.

It is a medicinal herb that is used for treating asthma, sedation, blood pressure, vasodilation, and antibacterial activity.

The primordium is the stem of the tuberous root of Araliaceae. It has been reported that pruning reduces fever and increases urination to promote gonorrhea, urethritis, cystitis, and postpartum lactation.

It is also called Noni, and leaves, stems, flowers, fruits and seeds have been used in folk remedies. According to ancient literature in the South Pacific region, it is recorded as the best natural remedy. In fact, it contains anthraquinone and serotonin, which helps digestion, reduces pain, and works on hypertension and cancer. It usually grows deep down on volcanic soil.

Fado is an evergreen broad-leaved shrub with the main pole. It is a medicinal substance with a tastful and zealous poison. It is used for constipation when the stomach is full due to water in the stomach.

Porcupine refers to a medicinal plant that has dried the outposts of dandelions or inbred plants. It is used for symptoms such as swelling, mastitis, sore throat, sore throat (appendicitis, lung abscess, peritonitis), eye congestion, acute hepatitis, jaundice and heat. The pharmacological action was reported to be the insecticidal action, the immune function enhancement, the bile secretion action, the liver function protection action, and the diuretic action.

Bojang refers to the pollen of the parts or subspecies with the parts. Bojang is used for hemostasis, convergence, and teratogenesis. It is used for hematemesis, hematemesis, nose bleeding, urinary hemorrhage and uterine hemorrhage. It improves blood circulation and blood circulates in the chest. Pharmacological actions have been reported such as uterine agitation, hypotension, shrinkage, shortening of blood coagulation time, inhibition of mycobacteria growth, and cholesterol lowering.

Inflatable orchids are called inflatable boats. It grows in coniferous forests and is about 30cm high. The rootstock is fleshy and ellipsoidal, with one leaf and stem at the end. Leaves are petiole, egg-shaped or oval-shaped. The tip of the leaf is pointed, the bottom is round, the wrinkles are vertical, and the back side is purplish.

Hassuo is a Chinese origin and is being cultivated as a medicinal plant. The roots of reddish brown roots are called "Sasao" in one room, and they are used as tonic, gaepjeong, and emollient. Leaves are herbs and attached to the roasted leaves to absorb pus.

The alliance is also called the maggot. It grows in wetlands, stands straight and grows up to 50-80cm high. The branch is divided and the hollow is on the upper part. Leaves are alternate and once folded leaves. Small leaves are 20 ~ 30 pairs, oval with a stripe shape, flat on the edge and white on the back.

A passer-by is an acronym for the word "cough", asthma, and constipation.

It is a sunflower seed that lowers cholesterol levels and prevents cardiovascular disease and arteriosclerosis. It is also rich in minerals such as calcium, potassium, and iron. It is also effective for people with weak digestive system, weak body, and weakness. Vitamin B antibodies are also abundant, so they have a beneficial effect on hypertension and nervousness.

The rootstock is a perennial plant of the genus Chrysanthemum, and the root of the root at the end of the root contains essential oil and fatty oil. It is reported that it is used for headache, abdominal pain and menstrual irregularity in the oriental medicine and also as a eukaryotic agent of pulmonary tuberculosis in the private sector.

Ovum is a plant of Lamiaceae and is also known as Noyagi. It is reported that dried herbal extracts are used to treat sweating, fever, diuretic, diaphoresis, sweating, swelling, stomach, gastritis, hematocrit and bad breath.

Incense is the fruit of the tree. The incense sticks have the efficacy of giant wind, scattered cold, and pain relief, and have a rich external appearance (风寒 外感), heart cramps (心 胃气 痛), rheumatism joint pain, Cure.

Echobo is also called bamboo, and refers to the parts of the buds or pollen of the same plants. It is used for hemostasis, convergence, and hemostasis. It is used for hemostasis, hemorrhage, nose bleeding, urinary hemorrhage, uterine hemorrhage, improvement of blood circulation, and blood clotting in the chest. Pharmacological actions have been reported such as uterine agitation, hypotension, shrinkage, shortening of blood coagulation time, inhibition of mycobacteria growth, and cholesterol lowering.

Hyungsam is a perennial plant with hyangsam, which is also known as a middle stage, a modern stage, a demon stage, and a shaman horse. In the oriental medicine, it is reported that the roots are used as antipyretics, boils,

The local candle refers to a year-round shoot lanceolate with a raspberry, and it removes the customs and communicates meridians to strengthen the skeleton and muscles, so that it can be used for limb paralysis, joint discomfort, bruise. It also has effects on dysentery, chronic diarrhea, stomach pain, enteritis, itching, numbness and malaise.

Pale color is a perennial plant with poppy neck color and is also called south leaf, arc. In one study, tuberculosis was reported to be used as a purulent, antispasmodic, and analgesic agent.

The mold is reported to be used in the first year of a lepidoptera when the herb is dried in a herb and is called a mold. It is reported to be used when a fever occurs due to a cold, a headache occurs, a sore throat, or blood in a tumor.

It is said that horseshoe is a word from sesame or black sesame, and it is said to be effective for people with warts or gray hair.

Hora is an annual plant of rosemary beans and grows up to about 50cm in height. Horopa usually is sun-dried and medicated. The seed contains a very small amount of essential oil, which contains about 40 ingredients, including several types of alkaloids, proteins, and fats. It is warm and poisonous, and has been used in Africa, the Middle East, and India to treat bladder and kidney diseases from old times, and has also been used to treat people with cold or swollen diarrhea. Today, it is known that it is effective in maintaining the balance between insulin and blood sugar in the body, and is also known to have an effect on weight control.

Pumpkin is an annual vine of peach and it is said to be highest in potatoes, sweet potatoes, beans and calories since it has the highest starch content among fruit and vegetables. It is usually used as a cooking ingredient. It contains a large amount of vitamin A and contains a small amount of vitamins B and C, which is very important as a vitamin source.

Hongmong Ogapi refers to a thorny potato leaf.

Red ginseng is steamed red ginseng and has sedative and excitatory action against the central nervous system. It acts on the circulatory system to prevent hypertension and arteriosclerosis. In addition, it also acts to reduce hematopoiesis and blood glucose levels, to protect the liver, to work on the endocrine system, indirectly to sexual behavior and reproductive effects, And antitumor action (anti-tumor effect), radiation protection effect, skin protection and softening action. Among the effects of red ginseng, adaptogen (aptogen) effect has the ability to enhance the ability of the living body to adapt more easily to various diseases, Scientifically proven.

Black tea mushroom is a drink with sugar that is similar to lemon tea cultivated by culturing yeast. Most of the syrup is acetic acid, and other organic acids such as gluconic acid are also contained.

The tea plant is a bean and a perennial plant, and is called a red shamrock and a gold flower. In folk remedies, the outpost was used as diuretic, analgesic, digestive process, sputum, hemostatic, and other medicinal materials.

The safflower is called safflower, and the dried one is called safflower, and it is used in women's medicine, gyeongyeong, abdominal pain in one side and oil for kerosene and edible oil for kerosene. The seed oil has a lot of linolic acid Good for the prevention and treatment of arteriosclerosis due to cholesterol excess.

The horn is located outside of the stamen and pistil, and is a flower element that protects the stamen and pistil. It is also called a flower cover.

Gold is a perennial plant of the family Lamiaceae, and its roots are used as fever, diuretic, branch, insect and anti-inflammatory.

Hwanggi refers to a perennial plant of soybean. It is cultivated as an herb, and it is collected in autumn in one of the herbs, and it is called "Hwanggi" of herbal medicine which is dried in the sunlight by removing the 蘆 head and the root roots. , It has been reported that it is prescribe to the weakness of the body, fatigue boredom, blood depression, elimination, stomachache, internal sewage, cold sweat, peripheral nerve and the like.

Chrysanthemum is cultivated as a medicinal herb. It is called Hwangryeong (黄 连), which is rooted in the sun for about 5 ~ 6 years, It is prescribed for the treatment of indigestion and gastritis, enteritis, abdominal pain, vomiting, dysentery, heart palpitations, unpleasantness, mental anxiety, throat pain, blood clots, nosebleeds, .

Hwangjeong is the root of the bamboo, which is from one side. The body is fragile and has no energy.

It is used as a medicinal material in the herbal medicine, abdominal pain, abdominal pain, sputum, and sputum.

Hwang Baek is the dried peel of the tree which belongs to the hwanghwagae, and it is called Hwanggyeongpyeong. Peel off the trunk from the trunk before and after the leg, remove the rough skin, or cut and dry in the sun. This shell is used as a medicine and inhibits the development of hypoglycemia, pneumococcal, Mycobacterium tuberculosis, Staphylococcus aureus, inhibits the growth of tumor cells, and has a bactericidal action. When taken, the secretion of gastric juice is promoted by the increase of the taste reflex, and the edible use is also brought about. Since the general alkaloid does not have the systemic action, it can be used not only as a topical preparation but also as a side effect agent since it has no side effects even when administered in large amounts. In addition, it does not cause resistance of various bacteria to this medicinal product, so it can be used as a facial disinfectant when epidemic eye disease is prevalent. In addition, blood pressure drop, central nervous system depression, anti-inflammatory effects have been reported, and Dongyang medicine has been used in the Hwangryunhaokgang, Shihoqingangtang, and Xiaogangyangtang.

It is an evergreen tree belonging to the dicotyledonous plant of the dicotyledonous plant. It is called the thick skin of the bark in the oriental medicine. It is used for asthma and gastrointestinal disease.

Black seeds are black seeds of morning glory. They are harvested from September to October. They are dried in the sun and then picked dry ones. Only seeds are collected and dried. White seeds are white and white is white. There is no difference.

The sacrifice is a medicinal substance made by using the grounding department of the Aikido department or the court of the court. It is used for arthritis, paralysis of the extremities, bruxism, bruises and paralysis caused by paralysis, and swelling, rash, skin itching, and eczema. It is used for hypertension, headache, dizziness, acute hepatitis. The effect of pharmacological action on suppression of joint edema and hypotension was reported.

The fermented extract of the present invention is prepared by boiling or boiling the washed and dried natural product for 30 minutes to 2 hours; Cooling the boiled or natural product for 30 minutes to 1 hour at room temperature; Wrapping or covering the cooled natural product with medicinal leaves and fermenting the mixture in a dark place for 4 to 7 days at room temperature; And removing the medicinal leaves from the fermented natural product and extracting them.

In general, when a natural product is fermented without mixing sugar, salt or yeast, the natural product is not fermented but rotten. However, when the natural product is fermented using the medicinal leaves according to the method of the present invention, the natural product rotates without addition of sugar, It is advantageous that it can be fermented.

The spinach extract of the present invention is contained in an amount of 0.001 to 30% by weight based on the total weight of the composition. If it is less than 0.001% by weight, a desired effect can not be expected. If it exceeds 30% by weight, the increase of the effect is insignificant and the formulation stability may be deteriorated.

The extract according to the present invention is excellent in skin antioxidation, anti-aging, whitening and moisturizing effect.

In the composition for external application for skin of the present invention, the composition for external application for skin may be a cosmetic composition having a softening agent, a nutritional lotion, a massage cream, a nutritional cream, an essence, a pack, a gel, Creams, patches, or spray formulations.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not limited to these examples.

[Example 1] Preparation of husked soybean extract fermented in the form of mulberry leaves

1.5 kg of commercial bean curd (= Seomyeon) was added to 2 L of water and boiled for 1 hour at medium temperature (60 ~ 80 ℃). After the beans were removed, they were cooled at room temperature for 1 hour. After cooling the mulberry leaves into 30 grams of mulberry leaves, the mulberry leaves were tightly bound together so that the mulberry leaves could not be loosened. In this way, the ingredients were wrapped in mulberry leaves and boiled for 7 days at room temperature in shade. After removing the mulberry leaves, the beans were recovered and crushed by a blender, and then 7 liters of 80% ethanol solution was added, refluxed three times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration through filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 344 g of soybean fermented soybean extract.

[Example 2] Preparation of Cornus syrup extract fermented in the form of lower leaves

1.5 kg of commercially available marine oil was poured in medium liquor (60 ~ 80 ° C) for 1 hour using 2 l of water. After extracting the steamed corn oil, it was cooled at room temperature for 1 hour, and 20 g of corn oil was wrapped in the lower leaf. In this way, the materials made by wrapping the steamed marine oil in the lower leaves were placed in a pot and stored in the shade for 7 days at room temperature. After the lower leaves were removed, corn oil was recovered and pulverized with a blender, and then 7 liters of 80% aqueous ethanol was added, refluxed for 3 times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 412 g of fermented cornstarch oilseed extract.

[Comparative Example 1] Preparation of soybean extract of rat brain

1.5 kg of commercial bean curd (= Seomyeongtae) was pulverized with a blender, and 7 liters of 80% ethanol aqueous solution was added, refluxed for 3 times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and the filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 386 g of a soybean extract.

[Comparative Example 2] Preparation of soybean extract of common fermented wheatgrass

1.5 kg of commercial bean curd (= Seomyeon) was added to 2 L of water and boiled for 1 hour at medium temperature (60 ~ 80 ℃). After the beans were boiled, the beans were cooled at room temperature for 1 hour, and then the beans were kept in the shade at room temperature for 7 days. At this time, unlike the above Examples 1 and 2, it was observed that the fermentation of the soybean is not properly performed and rot. Then, the beans were pulverized with a blender, and then 7 liters of an 80% aqueous ethanol solution was added, refluxed three times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 368 g of a soybean extract as a general fermented wheat.

[Comparative Example 3] Preparation of general fermented mulberry leaf extract

1 kg of commercial mulberry leaves were added to 2 liters of water and boiled for 10 minutes at medium temperature (60 to 80 ° C). After removing the mulberry leaves, they were allowed to cool for 1 hour at room temperature, and they were stored in the shade for 7 days at room temperature. At this time, unlike the above Examples 1 and 2, the fermentation of the mulberry leaves was not properly performed, and it was observed that the mulberry leaves rot. After that, the mulberry leaves were pulverized with a blender, and then 7 liters of an 80% ethanol aqueous solution was added, refluxed three times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 258 g of a general fermented mulberry leaf extract.

[Comparative Example 4] Preparation of acidified milk extract

1.5 kg of commercially available corn oil was pulverized with a blender, and then 7 liters of an 80% aqueous ethanol solution was added, refluxed for 3 times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and the filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 355 g of a crude oil extract.

[Comparative Example 5] Preparation of general fermented corn oil extract

Add 1.5 kg of commercially available marine oil to 2 liters of water and pour it over medium heat (60 ~ 80 ℃) for 1 hour. Steamed corn oil was extracted and cooled for 1 hour at room temperature. Cornus syrup was placed in a pot and stored at room temperature for 7 days. At this time, unlike the above Examples 1 and 2, it was observed that the fermentation of corn oil was not properly performed and rotted. Then, the acidified milk was pulverized with a blender, and then 7 liters of an 80% aqueous ethanol solution was added, refluxed three times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and the filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 331 g of a general fermented sour milk extract.

[Comparative Example 6] Preparation of general fermented lower back lobe extract

One kilogram of commercial lower leaves was added to 2 liters of water and boiled for 10 minutes at medium temperature (60 to 80 ° C). After boiling the leaves, they were cooled at room temperature for 1 hour and stored in the shade for 7 days at room temperature. At this time, unlike Examples 1 and 2, it was observed that the lower leaves were not fermented properly and rotted. After that, the lower leaf was pulverized with a blender, and 7 liters of 80% ethanol aqueous solution was added, and the mixture was refluxed three times and then immersed at 15 ° C for 1 day. Thereafter, the residue and the filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 263 g of a general fermented lowland leaf extract.

[Comparative Example 7] Preparation of soybean extract obtained by mixing fermented mulberry leaves

1.5 kg of commercial bean curd (= Seomyeon) was added to 2 L of water and boiled for 1 hour at medium temperature (60 ~ 80 ℃). After boiling, the beans were cooled and then cooled for 1 hour at room temperature. 10g of mulberry leaves were cut into 30g of soybeans. In this way, mixed mulberry leaves were kept in the shade at room temperature for 7 days by putting the bean ingredients into the pot. After removing the mulberry leaves, only the beans were collected and pulverized with a blender, and then 7 liters of 80% aqueous ethanol was added, refluxed three times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration through filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 351 g of soybean extract of mixed mulberry leaf.

[Comparative Example 8] Preparation of a crude oil-extracted milk fermented in a low-leaf mixture form

1.5 kg of commercially available marine oil was poured in medium liquor (60 ~ 80 ° C) for 1 hour using 2 l of water. Steamed corn oil was extracted and cooled at room temperature for 1 hour. In this way, steamed corn oil mixed with lower leaves was put in a pot and stored in a shade for 7 days at room temperature. After removing the lower leaves, only the acidified milk was recovered and pulverized with a blender, and then 7 liters of 80% aqueous ethanol solution was added, refluxed for 3 times, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration and centrifugation through a filter cloth, and the separated filtrate was concentrated under reduced pressure to obtain 408 g of a lower-leaf mixed fermented corn oil extract.

[Test Example 1] Antioxidant effect test (DPPH test)

To investigate the antioxidative effects of the extracts prepared in Comparative Examples 1 to 8 and Examples 1 and 2, organic radicals such as DPPH (1,1-diphenyl-2-picrylhydrazyl; 1,1-diphenyl-2 (antioxidant is oxidized) by the reduction of picryl hydrazyl (picryl hydrazyl). That is, the degree of decrease in the absorbance of the extract obtained in Comparative Examples 1 to 8 and the extracts obtained in Examples 1 and 2 by inhibiting the oxidation of DPPH was measured to be 50% or less of the absorbance of the control group Was evaluated as an effective antioxidant concentration.

The reaction solution was prepared by adding 190 μl of 100 μM (in ethanol) DPPH solution, 10 μl each of the above-mentioned Comparative Examples 1 to 8, Examples 1 and 2 and the positive control group, reacted at 37 ° C. for 30 minutes, Respectively. Trolox, a synthetic antioxidant widely used as a positive control, was used. The DPPH analysis results of each substance are shown in Table 1 below, and IC ₅₀ means the sample concentration when the absorbance was reduced by 50% by the added sample.

DPPH analysis result Test substance IC ₅₀ (ppm) Trolox 45 Comparative Example 1 Pea extract 66 Comparative Example 2 Common fermented rice husk soybean extract 96 Comparative Example 3 General fermented mulberry leaf extract 91 Comparative Example 4 Corn oil extract 71 Comparative Example 5 Common Fermented Corn Oil Extract 99 Comparative Example 6 General fermented lowland extract 80 Comparative Example 7 Mixed fermented soybean extract with mulberry leaves 47 Comparative Example 8 Lower leaf mixed fermented corn oil extract 54 Example 1 Mulberry leaf sprout fermented rice husk soybean extract 19 Example 2 Extract of fermented corn oil 24

As can be seen in Table 1, the antioxidative activities of the soybean extract and the lower extract of fermented corn oil were lower than those of the fresh extracts (Comparative Examples 1 and 4) and the positive control group Compared with Trolox, a synthetic antioxidant, the effect was even better. On the other hand, the general fermented extract fermented without medicinal leaves (Comparative Examples 2 and 5) showed almost no antioxidative effect. In the case of simple mixed fermented extracts (Comparative Examples 7 and 8), which were not in the form of a sachet, the antioxidative activity was somewhat increased compared to that of the natural extract, but the effect was less than that of the sausage type fermentation method.

Thus, the medicinal herbal fermented extract according to the present invention has excellent antioxidative effect.

Test Example 2 Anti-Aging Effect Test I (Measurement of collagenase expression inhibitory effect)

The ability of the extracts obtained in Comparative Examples 1 to 8 and Examples 1 and 2 to inhibit collagenase production was measured in comparison with tocopherol and EGCG. Tocopherol and EGCG are antioxidants that are known to regenerate epidermal cells of the skin and prevent aging of the skin.

The test was carried out by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing 2.5% fetal bovine serum-containing DMEM (Dulbecco's Modified Eagle's Media) And cultured until it grew to about 90%. Then, the cells were cultured in a serum-free DMEM medium for 24 hours. Then, the extracts of Comparative Examples 1 to 8 and Examples 1 and 2 dissolved in serum-free DMEM medium, tocopherol and EGCG were treated for 24 hours at a concentration of 10 ^-4 mol After that, the cell culture solution was collected.

The collected cell culture medium was assayed for collagenase production using a commercially available collagenase measuring device (Amersham Pharmacia, USA). First, the cell culture solution collected in a 96-well plate uniformly coated with the primary collagenase antibody was added and the antigen-antibody reaction was performed in a thermostatic chamber for 3 hours.

After 3 hours, the second collagen antibody bound to the chromophore was placed in a 96-well plate and reacted for another 15 minutes. After 15 minutes, the color development inducing substance was added and coloration was induced at room temperature for 15 minutes. When the reaction (color development) was stopped by adding 1 M sulfuric acid again, the color of reaction solution was yellow and the degree of yellow was different according to the degree of reaction progress.

The absorbance of a yellow 96-well plate was measured at 405 nm using a spectrophotometer and the degree of synthesis of collagenase was calculated by the following equation (1). At this time, the reaction absorbance of the cell culture obtained from the untreated group was used as a control. That is, the degree of expression of collagenase in the untreated group was set at 100, and the degree of expression of collagenase in the group treated with the test substance was determined, and the results are shown in Table 2 below.

Test substance Expression level of collagenase (%) Untreated group 100 Tocopherol 75 EGCG 60 Comparative Example 1 Pea extract 91 Comparative Example 2 Common fermented rice husk soybean extract 99 Comparative Example 3 General fermented mulberry leaf extract 94 Comparative Example 4 Corn oil extract 89 Comparative Example 5 Common Fermented Corn Oil Extract 98 Comparative Example 6 General fermented lowland extract 90 Comparative Example 7 Mixed fermented soybean extract with mulberry leaves 81 Comparative Example 8 Lower leaf mixed fermented corn oil extract 79 Example 1 Mulberry leaf sprout fermented rice husk soybean extract 69 Example 2 Extract of fermented corn oil 60

The lower the degree of expression of collagenase, the higher the ability to inhibit the expression of collagenase and the less collagen decomposition in the skin, resulting in a smaller amount of wrinkles. The results are shown in Table 2. The results are shown in Table 2. In Table 2, the extracts of soybean extract and fermented soybean milk extract of Mulberry leaf sprout according to the present invention were in vitro in vitro inhibited the expression of collagenase more effectively than the biological extracts (Comparative Examples 1 and 4), and it was confirmed that the inhibitory effect on collagenase expression was better than that of tocopherol, which is known as an antioxidant. On the other hand, the general fermented extract fermented without medicinal leaves (Comparative Examples 2 and 5) showed that the inhibitory effect on the expression of collagenase was similar to that of the untreated group and had almost no anti-aging effect. In the case of the simple mixed fermentation extracts (Comparative Examples 7 and 8) which were not in the form of a sponge, the inhibitory effect on collagenase expression was somewhat increased as compared with the bamboo extract, but the effect thereof was insufficient compared with the case of the fermentation method.

Thus, the medicinal herbal fermented extract according to the present invention effectively inhibited the expression of collagenase, thereby reducing collagen degradation in the skin, and thus exhibiting excellent anti-aging effect.

[Test Example 3] Anti-aging effect test II (experiment for promoting the production of procollagen)

The ability of the extracts obtained in Comparative Examples 1 to 8 and Examples 1 to 2 to produce procollagen was compared with vitamin C. Pro-collagen is a collagen-inducing substance that is necessary for collagen production and anti-aging. Vitamin C is known as an essential ingredient in the synthesis of collagen.

The test was carried out by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing 2.5% fetal bovine serum-containing DMEM (Dulbecco's Modified Eagle's Media) And cultured until it grew to about 90%. Thereafter, the cells were cultured in a serum-free DMEM medium for 24 hours, treated with the extracts of Comparative Examples 1 to 8, Examples 1 and 2 and vitamin C dissolved in a serum-free DMEM medium at a concentration of 10 ^-4 mol for 24 hours Then, the cell culture solution was collected. After 24 hours, the amount of procollagen liberated in the medium was measured using a procollagen type-1 C-peptide EIA kit (MK101, Takara, Japan).

The degree of procollagen production in the untreated group was taken as 100 and the degree of procollagen production in the group treated with the test substance was determined. The results are shown in Table 3 below.

Test substance Procollagen production (%) Untreated group 100 Vitamin C 120 Comparative Example 1 Pea extract 107 Comparative Example 2 Common fermented rice husk soybean extract 97 Comparative Example 3 General fermented mulberry leaf extract 102 Comparative Example 4 Corn oil extract 105 Comparative Example 5 Common Fermented Corn Oil Extract 98 Comparative Example 6 General fermented lowland extract 100 Comparative Example 7 Mixed fermented soybean extract with mulberry leaves 110 Comparative Example 8 Lower leaf mixed fermented corn oil extract 113 Example 1 Mulberry leaf sprout fermented rice husk soybean extract 126 Example 2 Extract of fermented corn oil 131

The higher the degree of production of procollagen, the higher the degree of production of collagen, and thus the generation of skin wrinkles can be prevented. As shown in the above Table 3, the extracts of fermented soybean curd and the extracts of fermented soybean meal from Mulberry leaf-sprouting fermented according to the present invention promoted the production of procollagen more effectively in vitro than the extracts of the present invention (Comparative Examples 1 and 4) It was confirmed that vitamin C, which is known to be an essential component for the synthesis of vitamin C, is superior in promoting the production of procollagen. On the other hand, the general fermentation extracts (Comparative Examples 2 and 5) fermented without medicinal leaves showed that the degree of procollagen production was similar to that of the non-treated group and had almost no anti-aging effect. In the case of the simple mixed fermentation extracts (Comparative Examples 7 and 8) which were not in the form of a sponge, the degree of pro-collagen production was somewhat increased as compared with the bamboo extract,

Accordingly, the medicinal herbal fermented extract according to the present invention effectively promotes the production of collagen, and thus the production of collagen in the skin is facilitated and the anti-aging effect is excellent.

[Test Example 4] Whitening effect test (measurement of inhibitory effect on melanin formation using mouse pigment cells)

The ability of the extracts obtained in Comparative Examples 1 to 8 and Examples 1 and 2 to inhibit melanin formation was measured in comparison with hydroquinone.

The cells were cultured in DMEM supplemented with 10% fetal bovine serum, 100 nM 12-O-Tetradecanoyl (10 nM) Acetate, and 1 nM cholera toxin at 37 ° C in the presence of 5% CO ₂ . The cultured Mel-Ab cells were removed with 0.25% trypsin-EDTA, and the cells were cultured at a concentration of 10 ⁵ cells / well (cells / well) in a 24-well plate. And cultured. As test substances, hydroquinone and the extracts of Comparative Examples 1 to 8 and Examples 1 and 2 were used at a concentration of 10 ppm, respectively. At this time, the hydroquinone was used as a positive control. Then, the culture solution was removed, washed with PBS, and the cells were dissolved with 1 N sodium hydroxide, and the absorbance at 400 nm was measured. The rate of inhibition of melanin production was calculated according to the following formula (2) Dooley's method).

Test substance Melanin production inhibition rate (%) Untreated group 100 Hydroquinone (positive control) 41.1 Comparative Example 1 Pea extract 97.2 Comparative Example 2 Common fermented rice husk soybean extract 99.4 Comparative Example 3 General fermented mulberry leaf extract 99.1 Comparative Example 4 Corn oil extract 101.2 Comparative Example 5 Common Fermented Corn Oil Extract 100.3 Comparative Example 6 General fermented lowland extract 99.7 Comparative Example 7 Mixed fermented soybean extract with mulberry leaves 65.9 Comparative Example 8 Lower leaf mixed fermented corn oil extract 70.2 Example 1 Mulberry leaf sprout fermented rice husk soybean extract 40.3 Example 2 Extract of fermented corn oil 41.4

As shown in Table 4 above, the extracts of soybean fermented soybean extract and fermented soybean milk extract of the present invention effectively inhibited the production of melanin than the extracts of the present invention (Comparative Examples 1 and 4), and the known whitening substances, hydroquinone A similar degree of inhibition of melanin production was observed. On the other hand, the general fermented extract fermented without medicinal leaves (Comparative Examples 2 and 5) showed almost no whitening effect at a level similar to that of the non-treated group. In the case of the simple mixed fermentation extracts (Comparative Examples 7 and 8), which are not in the form of a bundle, the rate of inhibiting melanin production was somewhat increased as compared with that of the biofilm extract, but the effect thereof was inferior to that of the packaged fermentation method.

Thus, the medicinal herb leaf extract according to the present invention effectively inhibited the production of melanin in the skin, so that the whitening effect was excellent.

[Test Example 5]

In order to compare the usability of kojic acid, a known whitening substance, with the mulberry leaf fermented soybean extract used as an active ingredient in the present invention, 15 panelists sensitive to stimuli such as stinging and burning were examined for the degree of stimulation such as hotness, Respectively.

The subjects were randomly assigned 0.5ml each of kojic acid (purchased from YM chemical) and the mulberry leaf fermented bean extract (Example 1) at random, rubbed and rubbed, and the score was scored between 0 and 3.0 in units of 0.1 Respectively. The results are shown in Table 5 below.

<Evaluation Criteria>

0 to 0.4: No stimulation

0.5 to 1.0: slight irritation

1.1 to 2.0: normal irritation

2.1 ~ 3.0: Severe irritation

Test substance division Stinginess Burning Average Kojic acid 0.85 0.50 0.68 Comparative Example 1 Pea extract 0.65 0.44 0.55 Comparative Example 2 Common fermented rice husk soybean extract 2.24 2.90 2.57 Comparative Example 3 General fermented mulberry leaf extract 2.45 3.00 2.73 Comparative Example 4 Corn oil extract 0.76 0.65 0.71 Comparative Example 5 Common Fermented Corn Oil Extract 1.98 2.44 2.21 Comparative Example 6 General fermented lowland extract 1.90 2.04 1.97 Comparative Example 7 Mixed fermented soybean extract with mulberry leaves 1.30 1.15 1.23 Comparative Example 8 Lower leaf mixed fermented corn oil extract 1.19 1.40 1.30 Example 1 Mulberry leaf sprout fermented rice husk soybean extract 0.14 0.22 0.18 Example 2 Extract of fermented corn oil 0.42 0.30 0.36

As can be seen in Table 5, in the case of kojic acid, it was found that there was some degree of stinging and burning, and there was a feeling of irritation to the extent that it could be felt to some extent. In addition, the extracts of Comparative Examples 1 and 4 (Comparative Examples 1 and 4) had a slight sensation of irritation, and the general fermented extract fermented without the medicinal leaves (Comparative Examples 2 and 5) showed severe irritation. In the case of the simple mixed fermentation extracts (Comparative Examples 7 and 8), which are not in the form of a package, the degree of irritation is lower than that of the general fermentation extract, however, The sensation of irritation suggests that the use of these extracts would not be a good feeling. On the other hand, the extracts of soybean fermented soybean fermented soybean extract and fermented soybean fermented soybean extract used in the present invention showed almost no irritation due to almost no sense of both burning and stinging.

Therefore, it was confirmed that the medicinal-leafage fermented extract of the present invention has no irritating feel unlike kojic acid, and thus can provide a better feeling of use.

[Test Example 6] Skin moisturizing test (Differentiation induction test of human keratinocyte)

In order to confirm the skin barrier function and skin moisturizing ability of the extracts of Comparative Examples 1 to 8 and Examples 1 and 2, human keratinocytes cultured by primary culture using absorbance were placed in a culture flask and attached to the bottom , Comparative Examples 1 to 8 and Examples 1 and 2 were added to the culture solution prepared as shown in Table 6 below, and the cells were cultured for 5 days until the cells were grown to about 70 to 80% of the floor area. The cells were harvested and washed with PBS (phosphate buffered saline). The cells were washed with 10 mM Tris-HCl buffer (Tris-HCl buffer, pH 7.4) containing 2% SDS (sodium dodecyl sulfate) and 20 mM DTT (Dithiothreitol) , pH 7.4), sonication was performed for 3 minutes, and the mixture was boiled for 10 minutes. This was centrifuged at 1200 rpm for 30 minutes, and the separated precipitate was suspended in 1 ml of PBS and the absorbance at 340 nm was measured.

Separately, a part of the solution after the sonication was taken to measure the protein content, and was used as a standard for evaluation of the degree of cell differentiation. The test results are shown in Table 6 below, in which low calcium (0.03 mM) treated group and high calcium (1.2 mM) treated group are negative / positive control group, and low calcium concentration test substance is added.

Test substance Concentration used The ability to differentiate in keratinocytes (%) Control group Low Ca &lt; ^{2 +} & gt ^; (0.03 mM) 100 Control group High Ca ^{2 +} (1.2 mM) 206 Pea extract
(Comparative Example 1) 0.1 ppm 107 0.05 ppm 96 General fermentation
Pea extract
(Comparative Example 2) 0.1 ppm 110 0.05 ppm 103 General fermentation
Mulberry leaf extract
(Comparative Example 3) 0.1 ppm 98 0.05 ppm 91 Corn oil extract
(Comparative Example 4) 0.1 ppm 112 0.05 ppm 100 General fermentation
Corn oil extract
(Comparative Example 5) 0.1 ppm 121 0.05 ppm 110 General fermentation
Low-leaf extract
(Comparative Example 6) 0.1 ppm 99 0.05 ppm 92 Mulberry leaf mixture fermentation
Pea extract
(Comparative Example 7) 0.1 ppm 159 0.05 ppm 139 Bottom leaf mixed fermentation
Corn oil extract
(Comparative Example 8) 0.1 ppm 166 0.05 ppm 134 Mulberry leaves
Pea extract
(Example 1) 0.1 ppm 198 0.05 ppm 180 Fermentation
Corn oil extract
(Example 2) 0.1 ppm 195 0.05 ppm 183

As shown in Table 6, when the amount of CE (cornified envelope) produced upon keratinocyte differentiation was measured to compare cell proliferation promoting effects, It can be seen that the extracts of fermented soybean curd and the fermented soybean milk extract of Mulberry leaf sprout fermented according to the present invention promote differentiation from keratinocytes more effectively than the biomass extracts (Comparative Examples 1 and 4) and general fermented extracts (Comparative Examples 2 and 5) there was. Therefore, it was found that the medicinal leaf fermentation extract according to the present invention enhances the barrier function of the skin and improves the skin moisturizing ability. In the case of the simple mixed fermentation extracts (Comparative Examples 7 and 8) which were not in the form of a sponge, the ability to differentiate in the keratinocytes was somewhat increased as compared with that of the bamboo extract, but the effect thereof was insufficient compared with the case of the fermentation method.

Hereinafter, formulation examples of the composition will be described, but the present invention is not intended to be limited thereto but is specifically described.

[Formulation Example 1] Nutritional lotion

Nutrition lotion was prepared according to the conventional method according to the composition shown in the following table.

ingredient Content (% by weight) (Example 1) &lt; tb &gt; &lt; tb & 5.0 Squalane 5.0 Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.5 Liquid paraffin 0.5 Caprylic / capric triglyceride 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance Sum 100

[Formulation Example 2] Nourishing cream

Nutritive creams were prepared according to the compositions listed in the following table in a conventional manner.

ingredient Content (% by weight) (Example 1) &lt; tb &gt; &lt; tb & 5.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 PEG60 hardened castor oil 2.0 Liquid paraffin 10.0 Squalane 5.0 Caprylic / capric triglyceride 5.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance Sum 100

[Formulation Example 3] Massage cream

Massage creams were prepared in a conventional manner according to the composition shown in the following table.

ingredient Content (% by weight) (Example 1) &lt; tb &gt; &lt; tb & 5.0 Wax 10.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.8 PEG60 hardened castor oil 2.0 Liquid paraffin 40.0 Squalane 5.0 Caprylic / capric triglyceride 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance Sum 100

[Formulation Example 4] Pack

Packs were prepared in a conventional manner according to the composition shown in the following table.

ingredient Content (% by weight) (Example 1) &lt; tb &gt; &lt; tb & 5.0 Polyvinyl alcohol 13.0 Sodium carboxymethylcellulose 0.2 glycerin 5.0 Allantoin 0.1 ethanol 6.0 PEG 12 nonyl phenyl ether 0.3 Polysorbate 60 0.3 Preservative, coloring, fragrance Suitable amount Purified water Balance Sum 100

Those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims.

Claims (11)

A composition for external application for skin, which comprises a fermented extract of spinach produced by wrapping or covering a natural product with medicinal leaves and fermenting it,
The natural product is soybean or marine oil,
The medicinal leaves are mulberry leaves or lower leaves,
The fermentation extract is prepared by boiling or boiling the washed and dried natural product for 30 minutes to 2 hours;
Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour;
Wrapping or covering the cooled natural product with the medicinal leaves and fermenting the mixture at room temperature for 4 to 7 days in the dark; And
Removing and extracting the medicinal leaves from the fermented natural product;
&Lt; / RTI &gt; wherein the composition is prepared by a method comprising the steps of: The composition for external application for skin according to claim 1, wherein the soybean is a bean curd. The composition for external application for skin according to claim 1, wherein the extraction is performed with water, ethanol or a mixed solvent thereof. [2] The composition for external application for skin according to claim 1, wherein the content of the fermented extract is 0.001 to 30% by weight based on the total weight of the composition. The composition for external application for skin according to any one of claims 1 to 4, wherein the composition is for antioxidation. 5. The composition for external application for skin according to any one of claims 1 to 4, wherein the composition is for skin elasticity enhancement. The composition for external application for skin according to any one of claims 1 to 4, wherein the composition is for skin whitening. The composition for external application for skin according to any one of claims 1 to 4, wherein the composition is for skin moisturizing. 5. The composition according to any one of claims 1 to 4, wherein the composition has cosmetic formulations of softening agent, nutritional lotion, massage cream, nutritional cream, essence, pack, gel, ampoule or skin adhesive type, , A gel, a cream, a patch, or a spray agent. delete delete