KR102030275B1 - Hair cleanser composition - Google Patents

Abstract

The present invention relates to a hair cleanser composition. The present invention provides a comprehensive functional product capable of improving scalp conditions such as inflammation relief and having an effect of dyeing gray hair in addition to hair loss prevention and hair growth promoting effect.

Description

Hair cleaner composition {HAIR CLEANSER COMPOSITION}

The present invention relates to a hair cleaning composition for preventing hair loss and promoting hair growth.

In recent years, the hair loss population continues to increase due to environmental pollution, side effects due to drug abuse, and social and environmental stress. Hair loss in humans grows through growth, degeneration, and rest periods, and hair loss in these growth phases It is a symptom that is caused by a small number of hair in the degenerative or resting period.

Human hair is an important part of the body that expresses personality and personality. Unlike other mammals, human hair is recognized for its importance in an aesthetic sense rather than for biological purposes.

About 50-100 hairs fall out naturally in a normal person's hair, and hair loss is defined as excess hair falling out of the normal number of hairs due to various causes.

The most common hair loss diseases include alopecia areata caused by abnormal immune system and masculine alopecia that develops with age. The exact mechanism of hair growth and hair loss has not been fully understood to date, but the cause of hair loss is caused by a decrease in the function of the hair follicles due to the involvement of male hormones, a decrease in the metabolic function of the hair follicles and the hair follicles, local blood disorder due to scalp tension, malnutrition, Stress, drug side effects, genetic factors, autoimmunity, local infections, chemicals, leukemia, tuberculosis and other diseases such as tuberculosis.

Therefore, in order to prevent hair loss, hair loss is prevented by eating a hair loss medicine or by applying a hair loss preventing composition to the hair loss site.

On the other hand, in addition to hair loss, hair-related diseases include gray hair (white hair, blackfish), which is a phenomenon in which the hair turns white while the number and function of melanocytes in the hair root is reduced.

Scalp hair gray hair occurs in the 30s and 40s and can generally occur in the order of the side, the crown, and the back. Aging may be caused by aging, stress or genetic factors, drugs and chemicals, and may be treated medically for the treatment of the underlying hair disease, but hair dyes may be used for temporary or semi-permanent cosmetic effects. have.

In general, hair dyes may be classified into permanent hair dyes, semi-permanent hair dyes, and temporary hair dyes according to differences in dyeing effects. Permanent hair dyes are those in which the pigment-forming substance penetrates into the cortex or anhydrous layer inside the hair and may cause chemical changes to form insoluble pigments. Semipermanent hair dyes are those in which the pigment itself penetrates into the cuticle layer of the cortex or hair surface and is physically adsorbed. Temporary hair dyes are also those that physically adsorb the pigment only to the cuticle layer, which is the surface of the hair.

Among these, permanent hair dyes can be further divided into three types: vegetable hair dyes, metallic hair dyes and oxidative hair dyes. Metallic hair dyes use the principle of blackening when lead is oxidized, and they are rarely used because they are harmful to humans. Oxidized hair dyes have excellent dyeing effect and can be dyed in bright colors. Or there is a problem that damage the hair by dissolving the hair component by using an alkaline component.

Accordingly, a vegetable hair dye using a vegetable component including henna, chamomile and the like can be used.

Although researches have been conducted on hair regrowth and hair dye which can prevent various symptoms of scalp and hair such as hair loss and gray hair, and improve the condition of scalp and hair, the existing products are mainly chemicals, Many side effects were caused, and most of them focused on either scalp or hair to improve function, and it was difficult to find a product that could simultaneously improve hair loss and gray hair.

Therefore, there is an urgent need for the development of a comprehensive functional product that is safe for the living body and is easy to use, has a hair loss prevention and hair growth effect, has a dyeing effect on gray hair, and can improve scalp conditions such as inflammation reduction. It is true.

Republic of Korea Patent Publication No. 10-1758998

The present invention relates to a hair cleanser composition, and to provide a comprehensive functional product capable of improving scalp conditions such as inflammation reduction while having a hair dyeing effect as well as hair loss prevention and hair growth promoting effects.

The present invention (A) human adipose stem cell culture extract; (B) hyaluronic acid; (C) complex herbal extract consisting of Seomoktae, licorice, sewage, Angelica, irises, cheongung, pine needles, ginseng, green tea, cauliflower, nasturtium, sancho, safflower, wolfberry, gujeolcho, mint and jujube; And (D) provides a hair cleanser composition comprising a henna extract.

The hair cleanser composition of the present invention may include stem cell culture, hyaluronic acid, and complex herbal extracts, thereby preventing hair loss and promoting hair growth, improving dandruff and scalp itch, and hair moisturizing effect.

In addition, the present invention further comprises a henna extract, it is possible to further obtain the dyeing effect of gray hair without scalp irritation.

When using the hair cleanser composition of the present invention, improvement of the overall hair condition can be achieved.

Hereinafter, the present invention will be described in more detail to aid in understanding the present invention.

The present invention relates to a hair cleanser composition, specifically,

(A) human adipose stem cell culture extract;

(B) hyaluronic acid;

(C) complex herbal extract consisting of Seomoktae, licorice, sewage, Angelica, irises, cheongung, pine needles, ginseng, green tea, cauliflower, nasturtium, sancho, safflower, wolfberry, gujeolcho, mint and jujube; And

(D) characterized by comprising a henna extract.

On the other hand, as the hair to which the composition of the present invention is applied, hair, eyebrows, eyelashes, pubic hair, armpit hair, breast hair, nose hair, and leg hair Various hairs such as and the like may be included.

Hereinafter, each component of this invention is examined concretely.

(A) Human Adipose Stem Cell Culture Extract

The hair cleanser composition of the present invention is characterized in that it comprises a human adipose stem cell culture extract in order to exhibit the skin regeneration and anti-aging effect of the scalp, increase collagen synthesis of hair, hair growth and reduced hair follicle restoration effect.

The imaginary human-derived adipose stem cell culture extract means a stem cell culture extract obtained from an adult except for embryonic stem cells. Active ingredients of the human-derived adipose stem cell culture extract are mainly peptides and proteins that regulate cell growth, for example PDGF (platelet-derived growth factor), Basic FGF (basic fibroblast growth factor), KGF (keratinocyte growth). Factor), TGF-β1 (transformation growth factor), HGF (hepatocyte growth factor), VEGF (vascular endothelial growth factor), collagen, fibronectin, SOD (antioxidant enzyme), and the like. The human-derived adipose stem cell culture extract contains the growth factor described above, thereby promoting fibroblast migration, activating effect, skin regeneration and anti-aging effect, increased collagen synthesis, inhibitory activity of tyrosinase, and melanin synthesis. In addition, hair growth and reduced hair follicle restoration effects can be expected.

Stem cell culture extract of the present invention can be obtained by the method specified in US Patent No. 6,153,432 (2000.11.28).

First, adipose stem cells are separated from adipose tissue obtained through liposuction. It is suspended in the substrate medium and inoculated in a culture vessel and then incubated for 24 hours in a 37 ° C, CO ₂ incubator. When the fat stem cells adhere to the bottom of the culture vessel, the substrate medium is removed and a differentiation medium is added. After incubation for 3 days, adipocyte medium (adipocyte media) is added and differentiated into adipocytes. The differentiation of adipose stem cells begins at the beginning of the differentiation of small lipid droplets in the cytoplasm, gradually increasing the number of small lipid droplets, and gradually adding smaller lipid droplets to form large lipid droplets. Once fully matured, one lipid droplet occupies the entire cytoplasm and gradually increases in size during the maturation process. In the step of obtaining such adipose derived cells, the culture medium is serum-free DMEM medium, basic fibroblast growth factor (bFGF) and / or epidermal growth factor (EGF) 0.1 ~ The culture broth obtained by culturing with DMEM medium further containing 100 ng / ml concentration was separated and purified and used as the stem cell culture extract of the present invention.

Hair cleaning composition of the present invention is characterized in that it comprises 1 to 5 parts by weight, preferably 1 to 3 parts by weight of the human adipose stem cell culture extract based on 100 parts by weight of the composition.

When the composition of the present invention includes the human fat stem cell culture extract as much as the above range, collagen synthesis is increased, hair growth and reduced hair follicle restoration effect can be expected is preferable.

(B) hyaluronic acid

The hair cleanser composition of the present invention is characterized by including hyaluronic acid for moisturizing the scalp and hair to improve dandruff and scalp itching, antistatic effect, hair combing and hair gloss.

By using hyaluronic acid (HA) in combination with the complex herbal extract of the present invention, it supplies moisture to the scalp tissue and hair cells, and more effectively supplies the active ingredient of the complex herbal extract to prevent hair loss and promote hair growth. There is an effect to maximize.

Hair cleaning composition of the present invention is characterized in that it comprises 1 to 5 parts by weight, preferably 1 to 3 parts by weight of the hyaluronic acid based on 100 parts by weight of the composition.

When the composition of the present invention contains hyaluronic acid in the above range, it is preferable because it does not inhibit the dyeing effect while giving a moisturizing effect to the scalp and hair.

(C) complex herbal extract

The hair cleanser composition of the present invention is characterized in that it contains a complex herbal extract which is a natural ingredient harmless to the human body, in order to reduce hair loss and scalp inflammation as well as improve scalp blood circulation, prevent hair loss and promote hair growth.

Complex herbal extract of the present invention is characterized in that consisting of Seomoktae, licorice, sewage, Angelica, iris, cheongung, pine needles, ginseng, green tea, cabbage, nasturtium, sancho, safflower, wolfberry, gujeolcho, mint and jujube.

Seomoktae (Rhynchosia Nulubilis, 鼠目 太) used in the composition of the present invention contains cysteine, which is essential for hair growth, as a major source of protein, and is effective in preventing and delaying hair loss and preventing baldness. It is a kind of black soybeans called as small as a rat's eye.

In particular, Seomoktae is an antidote function that smoothes blood circulation and releases various poisons, and is effective in preventing anemia, hypertension, osteoporosis, and skin aging. Research has also shown that isoflavone, a bioactive substance, is 19.5 times more than ordinary soybeans.

Licorice (Glycyrrhiza uralensis Fischer) used in the composition of the present invention restores the function of the liver because it is gentle to the action of other herbs and detoxification in the liver, and in particular, Liquiritin, Liquiritigenin Such components inhibit the development of peptic ulcers and prevent hair loss.

In addition, licorice has an excellent effect on collagen synthesis and hyaluronic acid synthesis enhancement, and also has an inhibitory effect on melanin pigment production, and thus plays an effective role in skin elasticity and wrinkle improvement. More specifically, the licorice is a perennial herb, legume, upright with a height of 30-80 cm, the base is woody, branched, thin, reddish, straight, long and very sweet. Looking at the main components and efficacy of licorice, the main component is glysyrihizic acid, and other glybridine, saponaretin flavonoids, liqueur seeds, flavonoids, and tripenes. Saponin and the like.

Its properties are flat and it relieves the poisons of all kinds of medicines, tastes good, has no poisons, and combines toxic substances in the liver to restore the liver function, and is effective in drug addiction, infection, urticaria, dermatitis, eczema, etc. Neutralizes and removes or lowers toxic chemicals in harmony with all herbal ingredients.

The sewage used in the composition of the present invention is defined as a tuber of Polygonum multiflorum Thunberg, a perennial herb of Polygonaceae, which has a warm and astringent taste. , Herbology, Seoul, Younglim Publishing Co., 1991, 583-584), Korea, China and Japan. Sewage is divided into two types: Polygonum multiflorum Thunberg and Cynan chum wilfordii Hemsley. Sewage is cultivated mainly in Korea.

Sewage is a tonic, tonic, and emollient, which promotes the strength of the kidneys and strengthens the musculature, preventing hair loss and promoting hair growth, and making hair shiny and black. Lecithin, oxymethylanthraquinone derivatives, tannins, etc. are contained in the roots of sewage, and lecithin is one of the important phospholipids for cell structure and metabolism, and sewage is rich in lecithin. Has the effect of promoting growth and assimilation of the body. In addition, sewage contains a large amount of organic germanium. When oxygen is released from organic germanium, a large amount of oxygen is supplied to blood vessels, which expands capillaries, thereby improving blood flow, and reviving cells immediately before death. ) Will be activated.

Thus, when sewage is used in the hair cleanser composition of the present invention, since the metabolic activity of cells in the body, especially the scalp cells, becomes active, the scalp condition is improved, thereby preventing hair from falling out of the scalp.

Angelica used in the composition of the present invention is a root of Angelica gigas NAKAI belonging to the Apiaceae, which is warm, sweet, and very sweet in nature, and contains coumarin components such as decursin and decursinol. It is. Pain relief, drainage, hemostasis, blood, tonic action, especially blood circulation to improve the scalp and hair roots.

The iris used in the composition of the present invention is a perennial plant growing in a wetland. According to the province, Changpi, Jwapipul, and in Chinese characters Baekchang (白 昌), Seochang (臭 菖), Suchangpo (水 菖 浦), Leechang (泥 菖) is called. Plants similar to buds were named irises. Iris is a native plant that women have long liked. Hong Seok-mo's Dongkuk Taxation period describes that irises were used as hair cleaners on women's hair. Iris has aromatic substances throughout the roots, as well as the leaves and roots. Boil the irises, and the fragrant water comes out to be used as bath water. At this time, wormwood or donkey root is also boiled together. All have aromatic substances.

Cnidium officinale used in the composition of the present invention is a representative medicine for turning blood and qi well, which is good for headache, pain, sedation, and acupuncture points. It inhibits the activation of the melanocyte-stimulating hormones in the mother, prevents pigmentation and has a whitening effect.

More specifically, Cheongung is a perennial herb belonging to the Apaceae family, with a slightly spicy taste and warm properties. According to the agreement, "the bowels are indispensable for the treatment of headaches, and therefore, the bowels and bowels should be used when the crown and brain are sore." In other words, if the blood does not turn well in the body, headaches, dizziness, dysmenorrhea, dysmenorrhea, dysmenorrhea, abdominal pain, such as a variety of symptoms, such as the uterus improves these symptoms. In addition, there is a good effect on the pain caused by abnormal blood stagnation due to trauma or bruises. And it contains nutrients that will become anemia or blood components after pregnancy, which acts as a blood donor.

Therefore, when applied to hair and skin, it has skin tissue regeneration, exfoliation, and skin soothing effect. As well as donkey, it helps blood circulation and blood circulation well, prevents hair loss and promotes hair growth, and enhances moisturizing ability. It is effective to moisturize. In addition, when used with Angelica doubling the drug effect, and further enhance the efficacy of other medicines, there is an effect of exhibiting a large function in a small amount.

Pine needles used in the composition of the present invention, the properties are warm and bitter. Leaves of pine, the main constituents of which are terpentine oil, cineole, salinigrin, coniferin, P-Cymen, densipimaric acid acid), Retene, and chlorophyll, protein, phosphorus, iron, minerals, fat-soluble vitamin A and vitamin C. The Oriental medicine book says that the use of pine needles prevents the hair from whitening, and it is effective for forgetfulness by clearing the hair, clearing the hair, and helping to forgetfulness, comforting the intestines, and high blood pressure. It is also effective in preventing women's diseases such as women's beauty, insomnia, and hypothermia. Recently, pine needles have been found to promote the redox process of biological tissues, eliminate astringent inflammation, and stop blood.

Ginseng used in the composition of the present invention is warm and tasteful, 36 kinds of saponins, polyacetylene compounds having anti-proliferation and antioxidant activity against cancer cells, polyphenols showing supportive antioxidant activity related to anti-aging (poly phenol) compounds, acidic polysaccharides, such as protein-containing polysaccharides and anti-complement active polysaccharides that increase immune function and have bioprotective functions, crude fiber saccharides, adenosine, amino acids, vitamins B1, B2, B12, C, nicotinic acid Contains pantothenic acid and has Adaptogen Activity, which maintains homeostasis of body functions. It is effective in recovering from fatigue and relieving stress. It detoxifies heavy metals and prevents environmental hormone toxicity and improves blood circulation. It is known to be effective in preventing aging by promoting immune function.

Here, ginseng is a concept that includes leaves, stems, berries, or mixtures thereof. When applied to hair, ginseng activates hair cells, improves blood flow to the scalp, and helps to prevent hair loss by increasing skin blood flow, vitamins and amino acids. Nourishes damaged hair with ingredients such as to keep hair healthy.

Green tea (Green tea / Thea sinensis Linnaeus) used in the composition of the present invention is an evergreen tree or shrub belonging to Theaceae. Green tea is the second most widely consumed beverage after water, and its efficacy has long been studied. Green tea, black tea and oolong tea are produced from the leaves. The green tea is obtained by inactivating oxidation-related enzymes by vaporizing tea leaves, stems, or flowers, and keeping the polyphenol component stable. Polyphenols found in green tea are known as flavonols and catechins, and are known to have various effects such as antioxidant, anticancer, anti-inflammatory, and antibacterial properties.

Recently, it has been reported to reduce the sensitivity of the scalp, prevent dandruff, and inhibit hair loss-inducing hormone production.

The cabbage used in the composition of the present invention is a medicinal herb (Korea, Japan) made from the seeds of Prunus persica Batsch or Prunus persica Franchet var. Davidiana Maximowicz. Doin is used for removing abdominal pain, menstrual obstruction, menstrual irregularities, bruises, pulmonary abscess, appendicitis, lubrication of the intestines, used for constipation, skin itching, drying, blemishes, and freckles. As a pharmacological action, vasodilation, blood flow increase, uterine contraction and uterine hemostasis promotion, bowel movement, anti-inflammatory action, antitussive action, analgesic action, anti-allergic action, anti-tumor action and the like have been reported. When used on the scalp, it has excellent efficacy in improving scalp itch and preventing dandruff.

The nasturtium used in the composition of the present invention is cold in nature, sweet in taste, suitable for hair loss due to upper heat in young people, lowers heat and has excellent hemostatic effect, and has antibacterial, anti-inflammatory and anti-fungal effects, Clears and strengthens immune function, good for the treatment of boils and itching. In particular, nasturtium blackens the beard and gray hair, has a hair loss prevention and hair growth promoting effect.

Sancho used in the composition of the present invention is a medicinal herb made by removing seeds as much as the bark of Zanthoxylum piperitum De Candolle or the same plant. It is used for abdominal pain due to cold energy of the abdomen, diarrhea and toothache, and local anesthesia has been reported. Japanese pepper oil, the oil of the fruit of Japanese pepper, has the effect of preventing hair loss, especially when the eyebrows start to fall out.

Safflower used in the composition of the present invention, the height is about 1m, the flowers bloom yellow in July and August, the shape is like thistle, but over time becomes red. Fruits are 6mm long, white, glossy. The medicine consists of a red corolla, a yellow corolla, and a stamen. The length is about 10mm and five stamens surround the long pistil. It mainly acts on the heart and liver, helping to circulate blood throughout the body, releasing blood and at the same time relieving pain. Safflower is effective in treating hair loss through natural dyeing effect and hair growth promoting effect, and safflower seed oil is widely used as a hair essence.

Goji is used in the composition of the present invention is a tonic, sweet taste, and tonic to help the circulation of the Gi and blood, improve the liver, kidney function and smooth the metabolism of skin and hair cell tissue, when used with other medicines Increases the energy of the medicine, prevents hair loss and prevents baldness. In addition, the vitamin contains twice as much lemon, it helps with energy and vision, strengthens the knee and lower back joints and moisturizes. Wolfberry is used when the hair is thinner and weaker, and can improve hair gloss due to hair loss relief and hair moisturizing effects.

Gujeolcho (Chrysanthemum zawadskii var.latilobum) used in the composition of the present invention is a kind of wild chrysanthemum, and is known to be effective for gynecological diseases and warmth. In addition, gujeolcho is effective in preventing headache and hair loss, and prevents whitening of hair, and is known to be effective in healthy stomach, bowel, tonic, blood donation, appetite promotion, stroke and neuralgia. Furthermore, choline, known to be contained in gujeolcho, is an important basic structural unit of acetylcholine, a chemical that is involved in memory formation in the brain, and is known to play an important role in forming cell membranes in each tissue of the body. (Yook Chang-soo, Jung Nam-il, Lim Hyo-jong, Hyundai Pharmaceutical Cooperatives, 381 (1999), Culture History). Gujeolcho can strengthen the weakened roots and nourish the hair to improve the strength of the hair.

Mint (Mentha arvensis L) used in the composition of the present invention refers to perennial roots of dicotyledons with dicotyledons and mosses. Mint's main ingredient contains menthol, mentone, isomentone, camphor, limonene and the like.

Peppermint effect, fever, anti-inflammatory, stomach, bile secretion, increased mucous secretion of the respiratory tract, capillary dilation, central nervous system excitement, uterine contraction, better boil. Indigestion, sore throat, tonsillitis, skin itching, abdominal pain, diarrhea, vomiting, headache, toothache, cold, swelling, eye redness. When used for hair, it is effective in improving dandruff and scalp itching.

The jujube used in the composition of the present invention is a fruit of the jujube tree, which is red in color and is also called redness. The flesh of the jujube includes sugar, mucus, nebulic acid, tartaric acid and the like. Seeds of jujube include betulin, beturic acid, fat, and the like. Jujube is used as a diuretic tonic, soothing and nourishing medicine in oriental medicine, and is known to be effective in analgesic, detoxification, systemic pain, malnutrition, muscle spasms and drug addiction. Jujube can also be used to ferment, make the hair elastic, and improve the blood circulation of the scalp can improve the overall condition of the scalp and hair.

Complex herbal extract of the present invention may be prepared according to a conventional method for producing a plant extract, for example by adding an extraction solvent to the flowers, leaves, branches, roots, berries or shells or pulverized products of each component of the herbal medicine It may be prepared by fractionation by adding a fractional solvent to the crude extract prepared or prepared by extraction with an extraction solvent.

The extract may be an extract by at least one solvent selected from the group consisting of water, ethanol, methanol, propanol, butanol, acetone, ethyl acetate, hexane, butylene glycol, propylene glycol, hydrous butylene glycol, hydrous propylene glycol and hydrous glycerin Can be.

Complex herbal extract of the present invention may be prepared according to a conventional method for producing a plant extract, specifically may be cold extraction, hot extraction, thermal extraction, ultrasonic extraction, etc., conventional extraction equipment, ultrasonic grinding extractor or fraction Can be used.

In addition, the extract extracted with the solvent may be further subjected to the fractionation process with any one solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, ethyl ether, chloroform, water and mixtures thereof. Two or more solvents may be used in the fractionation, and each solvent extract may be prepared using sequentially or mixed according to the polarity of the solvent. In addition, the fractionation process may be performed at 4 ° C. to 120 ° C., or 50 ° C. to 90 ° C., or 70 ° C. to 85 ° C., but is not limited thereto.

The prepared extract or the fraction obtained by performing the fractionation process can be filtered or concentrated or dried to remove the solvent, it can be carried out both filtration, concentration and drying. Specifically, the filtration may be performed using a filter paper or a reduced pressure filter, the concentration may be concentrated under reduced pressure using a reduced pressure concentrator, for example, a rotary evaporator, and the drying may be performed by, for example, a lyophilization method.

On the other hand, the complex herbal extract is Seomoktae, licorice, sewage, Angelica, irises, cheongung, pine needles, ginseng, green tea, cabbage, nasturtium, sancho, safflower, wolfberry, gujeolcho, mint and jujube each weight ratio of 2: 0.5: 1: 1: 1: 0.5: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1.

Seomoktae is the main source of protein and contains cysteine, which is essential for hair growth, but also has the effect of preventing excessive baldness compared to other herbal medicines. Licorice and Cheongung have melanin synthesis inhibitory effect. The hair cleaning composition of the present invention for effect is characterized in that the addition of a small amount compared to other herbal medicines.

On the other hand, the hair cleanser composition of the present invention is characterized in that it comprises 1 to 50 parts by weight, preferably 1 to 30 parts by weight of the complex herbal extract based on 100 parts by weight of the composition.

When the composition of the present invention includes the complex herbal extract in the above range, it is preferable because it does not inhibit the dyeing effect while giving a moisturizing effect to the scalp and hair.

(D) Henna Extract

Hair cleaning composition of the present invention is characterized in that it further comprises a henna extract for the dyeing effect of gray hair.

Henna extract has been used as a cosmetic material such as tattoos and hair dyes in ancient times in Egypt, the Middle East, Africa and India since ancient times.It has antipyretic, astringent and antibiotic ingredients that can cause headache, inflammation, burns, ulcers, fever and nail splitting. It is also used as a preventive medicine. Henna as a hair dye has been handed down to Europe and has been widely used for hair dyeing and treatment since 1890.

Meanwhile, the hair cleanser composition of the present invention may include the henna extract in a microencapsulated form. The microcapsule is composed of a water-soluble component, but the henna composition is present inside the capsule in the hair cleanser composition, when water comes in contact with the hair cleansing, the capsule may dissolve and the henna composition may flow out.

In this case, the degree of dyeing effect can be appropriately selected by adjusting the degree of dissolution of the capsule according to the hair washing time.

Hair cleaning composition of the present invention is characterized in that it comprises 1 to 5 parts by weight, preferably 1 to 3 parts by weight of the henna extract based on 100 parts by weight of the composition.

When the composition of the present invention includes the henna extract as much as the above range, it is possible to prevent the pigmentation of the scalp while at the same time excellent hair dyeing effect.

The hair cleanser composition of the present invention may further include one or more additives selected from the group consisting of antioxidants, stabilizers, solubilizers, vitamins, pigments, fragrances and carriers, each of which is 0.1 based on 100 parts by weight of the composition. To 10 parts by weight, preferably 0.1 to 5 parts by weight.

There is no restriction | limiting in particular as a viscosity of the said hair cleaning composition, Although it can select suitably, 1 Pa.s-25 Pa.s are preferable at 25 degreeC, and 8 Pa.s-16 Pa.s are more preferable. When the said viscosity is less than 1 Pa.s, since it flows out from a hand at the time of use, it may become difficult to use, and when it exceeds 25 Pa.s, the discharge property from a container may worsen. In addition, as said viscosity, it can measure in 25 degreeC based on the quasi drug raw material standard general test method viscosity measuring method 2nd method.

There is no restriction | limiting in particular as a property and a formulation of the said hair cleaning composition, It can select suitably. As said property, a liquid form, a cream form, a foam form, a gel form, a wax form etc. are mentioned, for example. As said formulation, a pump type, a spray type, a tube type etc. are mentioned, for example.

The hair cleanser composition of the present invention can be used for hair shampoos, hair rinses, hair conditioners, hair treatments, hair tonics, scalp treatments, hair lotions, hair creams, hair nourishing cosmetics or general ointments.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily practice the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.

Preparation Example 1

For the present invention, the human adipose stem cell culture extract is separated from adipose stem cells from adipose tissue obtained through liposuction, suspended in a substrate medium, inoculated in a culture vessel, and then cultured in a 37 ° C., CO ₂ incubator for 24 hours. Once the adipose stem cells adhere to the bottom of the culture vessel, the substrate medium is removed and the differentiation medium (DIFFERENTIATION MEDIA) is added. After incubation for 3 days, adipocyte medium (adipocyte media) is added and differentiated into adipocytes. The differentiation stage of adipose stem cells matures at the beginning of differentiation, starting with the formation of small lipid droplets in the cytoplasm, gradually increasing the number of small lipid droplets, and gradually adding smaller lipid droplets to form large lipid droplets. Once fully matured, one lipid droplet occupies the entire cytoplasm and gradually increases in size during the maturation process. In the step of obtaining such fat-derived cells, the culture medium is serum-free DMEM medium, and basic fibroblast growth factor (bFGF) and / or epidermal growth factor (EGF) are 0.1 to each, respectively. The culture broth obtained by culturing with DMEM medium further containing 100 ng / ml concentration was separated and purified and used as the adipose stem cell culture extract of the present invention.

Preparation Example 2

Seomoktae, licorice, sewage, Angelica, iris, cheongung, pine needles, ginseng, green tea, Doin, nasturtium, sancho, safflower, wolfberry, gujeolcho, peppermint and jujube used in the present invention were purchased at Kyungdong Pharmaceutical Market. : 0.5: 1: 1: 1: 0.5: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1 and add purified water to 10 times the amount of raw material for 3 hours at 100 ℃ After extraction, the extract was filtered through a 250 mesh filter cloth (NBC inc. 38T05221-06), filtered through a 0.5um filter (MILLIPORE HVLP04700) and concentrated in a reduced pressure condenser (BUCHI Rotavapor R-210) equipped with a cooler to prepare a composite herbal extract. .

Example 1

Human fat stem cell culture extract of Preparation Example 1 and complex herbal extract, Hyaluronic Acid and Henna extract of Preparation Example 2 were added to the contents of Table 1 to prepare a hair cleanser (shampoo) according to a conventional manufacturing method.

ingredient Amount Human Adipose Stem Cell Culture Extract 3 Complex Herbal Extract 20 Hyaluronic acid 3 Henna extract 3 30% Sodium Lauryl Sulfate 10 30% Sodium Polyoxyethylurelauryl Sulfate 10 Palm oil fatty acid diethanolamide 2 Propylene glycol 2 Cocamidopropyl Betaine 3 Carboxy Vinyl Polymer 0.3 Polyquaternium-10 0.5 Paraoxybenzoic Acid Ester 0.2 Citric acid Quantity Spices Quantity Purified water Remaining amount

Comparative Example 1

The same hair cleaner as in Example 1 was prepared except that hyaluronic acid was not included in Example 1.

Comparative Example 2

The same hair cleaner as in Example 1 was prepared except that Seomoktae extract was not included in Example 1.

Comparative Example 3

The same hair cleaner as in Example 1 was prepared except that henna extract was not included in Example 1.

Experimental Example

The following physical properties were measured for the hair cleaners of Example 1 and Comparative Examples 1 to 3, and the results are shown in Tables 2 to 4.

1) Hair loss prevention effect test

In order to determine the hair loss prevention effect of the present invention, an experiment on the hair loss prevention effect was conducted for 30 weeks in 30 subjects with initial hair loss phenomenon. Subjects were rinsed every morning for 3 minutes using shampoo, and after 16 weeks, hair loss was collected and counted when washing hair, and the results are shown in Table 2 below.

Number of Dropout Hats (Number) / Standard Deviation Example 1 73.85 / 6.73 Comparative Example 1 91.50 / 9.10 Comparative Example 2 198.20 / 10.34

As can be seen from the results in Table 2, it can be seen that Example 1 including the hair cleanser composition of the present invention has a significantly reduced number of hair loss compared to Comparative Examples 1 and 2 that do not include hyaluronic acid or Seomoktae extract. there was.

2) Confirmation of improvement of scalp itch

In order to examine the scalp itch elimination effect of the present invention, 30 men and women with itching were washed every morning for 3 minutes using shampoo every morning, and after 7 days to evaluate the itch elimination effect of the scalp . Evaluation criteria are ineffective (1-2 points) and are usually (3-4 points), there are some (5-6 points), good (7-8 points), and are good (9-10 points), The average value of the results is shown in Table 3.

Example 1 Comparative Example 1 Scalp itching effect 7.9 5.2

As can be seen in Table 3, Example 1 including the hair cleanser composition of the present invention was shown to have an excellent itch removal effect compared to the comparative example does not contain hyaluronic acid.

3) Check the dyeing effect

In order to confirm the dyeing effect of the present invention, 20 women aged 25 to 40 years with gray hair were washed every morning for 3 minutes using a shampoo, and after 7 days, the dyeing effect was evaluated through self-diagnosis. The evaluation criteria are classified into no dyeing effect (1 point), slight dyeing effect (2 points), some dyeing effects (3 points), and excellent dyeing effects (4 points). The average value is shown in Table 4.

Example 1 Comparative Example 2 Comparative Example 3 Dyeing effect 3.7 3.2 1.8

As can be seen in Table 4, Example 1 including the hair cleanser composition of the present invention was confirmed to be significantly superior to the hair dye effect compared to the comparative example without the Seomoktae extract or henna extract.

The foregoing description of the present invention is intended for illustration, and it will be understood by those skilled in the art that the present invention may be easily modified in other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are exemplary in all respects and not restrictive.

Claims (7)

(A) human adipose stem cell culture extract;
(B) hyaluronic acid;
(C) complex herbal extract consisting of Seomoktae, licorice, sewage, Angelica, irises, cheongung, pine needles, ginseng, green tea, cauliflower, nasturtium, sancho, safflower, wolfberry, gujeolcho, mint and jujube; And
(D) comprising henna extract,
The compound herbal extract is a weight ratio of each component is 2: 0.5: 1: 1: 1: 0.5: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1,
Based on 100 parts by weight of the composition
(A) 1 to 5 parts by weight of the human adipose stem cell culture extract,
(B) 1 to 5 parts by weight of hyaluronic acid,
(C) 1 to 50 parts by weight of the composite herbal extract, and
(D) A hair cleaner composition comprising 1 to 5 parts by weight of henna extract.
The method of claim 1,
The ginseng comprises a leaf, stem, fruit, or a mixture thereof.
delete delete The method of claim 1,
The extract is an extract by one or more solvents selected from the group consisting of water, ethanol, methanol, propanol, butanol, acetone, ethyl acetate, hexane, butylene glycol, propylene glycol, hydrous butylene glycol, hydrous propylene glycol and hydrous glycerin Hair cleaner composition.
The method of claim 1,
The composition of claim 1, wherein the composition further comprises one or more additives selected from the group consisting of antioxidants, stabilizers, solubilizers, vitamins, pigments, flavors and carriers.
The method of claim 1,
The composition is a hair shampoo, hair rinse, hair conditioner, hair treatment, hair tonic, scalp treatment, hair lotion, hair cream or hair nourishment for use in the hair cleanser composition.