KR20180050003A - External Composition for inhibiting hair loss and enhancing hair growth with improved scalp permeability and hair maskpack comprising the same - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss and enhancing hair growth with improved scalp permeability and a hair mask pack comprising the composition, and more specifically, to an external composition which can prevent hair loss and promote hair growth while improving scalp penetration, and to a hair mask pack, which can make the scalp absorb the external preparation in a customized manner in accordance with the shape of a hair loss area of a user, and can make the scalp stably absorb the composition while reducing the amount of scalp heat generated by the user.

Description

[0001] The present invention relates to an external composition for hair loss prevention or hair growth promoting hair growth, and a hair pack comprising the same,

[0001] The present invention relates to a composition for preventing hair loss or for promoting growth of hair and a hair pack containing the same, and more particularly to a composition for external use which can improve hair penetration and prevent hair loss, A composition and a hair pack which can absorb the composition in a scalp customized to the user's hair loss pattern while stably absorbing the composition to the scalp while reducing the amount of scalp heat generated by a user.

Recently, the hair loss population is continuously increasing due to environmental pollution, side effects due to abuse of drugs, and social and environmental stress. The hair of the human body is removed through growth period, retrograde period and rest period. It is a symptom that is caused by a small number of hair in the retrogressive or resting period.

Human hair is an important part of the body expressing personality and personality. Unlike other mammals, human hair is recognized as being important in aesthetic sense rather than biological purpose.

About 50-100 of the normal hair fall off naturally, and hair loss is defined as dehydration, which is caused by excessive withdrawal of hair due to various reasons.

The most common hair loss is alopecia due to immune system abnormality and male hair loss caused by age. The precise mechanisms of hair growth and hair loss are not fully understood until now. However, the cause of hair loss is the decrease of hair follicle function due to the involvement of male hormone, the decrease of the metabolism function of hair follicle and parental part, the local blood flow obstruction due to scalp tension, Stress, drug side effects, genetic factors, autoimmunity, local infections, chemicals, leukemia, tuberculosis and abuse of hair products.

In order to prevent such hair loss, hair loss is prevented by eating the hair loss medicine or applying the hair loss prevention composition to the hair loss area.

However, in the case of male hair loss, various forms such as degenerative hair loss progressing from the front part of the head or circular hair loss progressing from the upper part of the head are shown. In the part where the hair loss is progressing, it is not easy to apply the hair loss prevention composition directly to the scalp have.

In other words, it is difficult to penetrate the scalp with the hair loss composition as a whole due to the area where the hair loss is not progressed around, and it is difficult for the user to apply the hair loss composition to the hair loss area while reflecting the mirror.

In addition, in the case of male-type hair loss, heat generated from the scalp also acts as a factor of hair loss. However, there is not yet disclosed a technique for reducing the occurrence of the scalp and promoting the scalp absorption of the hair loss composition.

Korean Patent Laid-Open Publication No. 2015-0060286 (Method for preventing hair loss from natural products by using ultrasonic waves or for producing composition for promoting hair growth) Korea Patent Publication No. 2016-0017890 (hair hair pack)

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art,

A composition comprising human adipose stem cell culture extract, goat ginseng extract, hydrolyzed soy protein, and 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide is used to improve scalp penetration and to prevent hair loss And the hair growth can be promoted, thereby completing the present invention.

Accordingly, an object of the present invention is to provide an external-application composition capable of improving scalp penetration, preventing hair loss, and promoting hair growth.

It is still another object of the present invention to provide a composition for preventing hair loss or for promoting growth of hair, which can be customized to be absorbed into the scalp according to the shape of the user's hair loss, while stably reducing the scalp heat generated by the user, And a composition for preventing hair loss or for promoting growth of hair.

On the other hand,

Wherein the hair follicle stem cell culture extract extract of human body fat stem cell ginseng extract, hydrolyzed soy protein and 4-pyrrolidine-2, 6-diaminopyrimidine-1-oxide, Or an external application composition for promoting hair growth.

The composition may further comprise one or more of yeast extract, yeast extract, green leaf extract, red ginseng extract, ginseng extract, di-panthenol, salicylic acid, biotin, zinc pyrichion, niacinamide, caprate peptide- .

The human adipose tissue stem cell culture extract is contained in an amount of 5 to 10 parts by weight based on 100 parts by weight of the total composition.

The ginseng extract of the present invention is contained in an amount of 3 to 5 parts by weight based on 100 parts by weight of the total composition.

Wherein the composition is selected from the group consisting of a hair shampoo, a hair conditioner, a hair conditioner, a hair treatment, a hair tonic, a scarf treatment, a hair lotion, a hair cream, a hair nutrition lotion or a general ointment.

On the other hand,

A hair-pack main body having a silicone-like resilient flexible material and having a round shape having a human head shape and a heat absorbing material stored therein;

Wherein the external application composition is contained in a circular absorbent sheet corresponding to a shape of a lower end portion of the hair pack body portion, the hair pack sheet is divided into hair loss regions and cut out so as to be cutable by the compartments; And

The insertion portion is formed in a plate shape corresponding to the shape of the body of the hair pack, and is formed of a flexible material having elasticity of silicon type. The insertion portion is inserted into the outer side to insert the body of the hair pack. The present invention provides a hair pack comprising a composition for preventing hair loss or for promoting growth of hair, which comprises a hair pack cover in which the incised hair pack sheet is segregable for each compartment and a plurality of through holes are formed in each compartment.

And a plurality of fine protrusions are formed on an outer surface of the hair pack cover.

The endothermic material is characterized by comprising an endothermic material, a polymeric resin, and a cross-linking agent of a polymer resin mixed with at least two members selected from the group consisting of urea, an inorganic salt, an inorganic ammonium salt and an alkali metal salt.

And the composition ratio of the composition is different from each other in each of the sections of the hair pack sheet.

The composition for external use according to the present invention not only penetrates to the dermal layer of the scalp but also penetrates into the hair follicle under the dermal layer, thereby improving the penetration of the scalp, preventing hair loss, and promoting hair growth.

In addition, the hair pack containing the composition for external use can reduce the heat of scalp generated from the user's scalp, thereby improving the absorption effect and the hair-loss prevention effect of the hair loss prevention composition, and the hair pack sheet containing the composition for external use, So that the absorption effect of the hair loss preventing composition of the user's hair loss site can be enhanced.

In addition, the composition for external application according to the present invention can prevent a user from alopecia prevention effect as well as side effects by using a natural substance.

1 is a reference view of a hair pack according to a preferred embodiment of the present invention.
2 is a configuration diagram of a hair pack according to a preferred embodiment of the present invention.
3 is a plan view of a hair pack sheet formed in a hair pack according to a preferred embodiment of the present invention.
FIG. 4 is a reference diagram showing a type of hair loss by a user
5 is a reference view of a hair pack sheet cut according to a user's hair loss type according to a preferred embodiment of the present invention.
FIG. 6 is a configuration diagram illustrating a configuration of a hair pack cover configured in a hair pack according to a preferred embodiment of the present invention.
FIG. 7 is a configuration diagram illustrating a configuration of a hair pack cover configured in a hair pack according to a preferred embodiment of the present invention.
8 is an experimental reference diagram of a preferred embodiment of the present invention.

Before describing the embodiments according to the present invention in detail, the present invention is not limited to the configurations shown in the following description or the accompanying drawings, but may be used or performed in various ways.

It is also to be understood that the phraseology or terminology employed herein is for the purpose of description and should not be regarded as limiting.

That is, as used herein, the terms "mounted", "installed", "connected", "connected", "supported", "coupled", etc. do not denote or denote otherwise It is used in a wide range of expressions, including both direct and indirect mounting, mounting, connection, connection, support, and engagement. The expressions "connected," "connected," and "coupled" are not limited to physical or mechanical connections, connections, or couplings.

In the present specification, terms indicating directions such as upper, lower, downward, upward, rearward, bottom, front, rear, etc. are used to describe the drawings, but these terms are used for convenience only, Time). Terms that express this direction should not be construed as limiting or limiting the invention in any way whatsoever.

Also, the terms "first", "second", "third", etc. used in this specification are for explanation purposes only and should not be construed to imply relative importance.

BEST MODE FOR CARRYING OUT THE INVENTION The composition for preventing hair loss or for promoting hair growth according to a preferred embodiment of the present invention will be described in detail below.

The composition for preventing hair loss or for promoting growth of hair, in which the scalp penetration effect is enhanced, may be included in the hair pack 10 described later.

The composition for preventing hair loss or for promoting hair growth, in which the effect of scalp penetration is enhanced according to one embodiment of the present invention,

Human adipose stem cell culture fluid extract, goat ginseng extract, hydrolyzed soy protein, and 4-pyrrolidine-2,6-diaminopyrimidine-1-oxide.

The composition for preventing hair loss or promoting growth of hair according to the present invention may further comprise at least one selected from the group consisting of yeast extract, Hwasung extract, Korean lobule extract, red ginseng extract, ginseng extract, di-panthenol, salicylic acid, biotene, , Niacinamide, capper tripeptide-1, herbal extracts, and henna extract.

The human adipocyte conditioned media extract is an extract of a stem cell culture liquid extract disclosed in Korean Patent Publication No. 2011-0119061 or Korean Patent Publication No. 2011-0119062, It is a kind of adult stem cells isolated from tissues. The acquisition of adipose tissue can be obtained incidentally during the liposuction process, which is usually performed, and thus it is possible to easily obtain and cultivate a sufficient amount of stem cells, and also has superior safety compared to bone marrow harvesting.

As a method for culturing stem cells for producing the stem cell culture fluid extract, it is possible to obtain stem cells-derived proteins from the stem cell culture after separating the stem cells by culturing cells in which fat has been removed from adipose tissue for several generations . This protein mixture contains EGF (epidermal growth factor), vEGF (vascular endothelial growth factor), TGF (transforming growth factor), HGF (hepatocyte growth factor), FGF (fibroblast growth factor), IGF And it has been reported that it contains about 150 growth factor protein components. Adipose stem cells are a type of adult stem cells that are easier to harvest than stem cells or cord blood stem cells, and massive stem cells are available because of their high stem cell content. Growth factor is the most important factor in the proliferation and differentiation of one cell. This growth factor plays a role to transmit signals that cause proliferation or differentiation of cells into the cells. Based on these signals, the cells divide and differentiate, and vivid and vital skin is maintained, and the condition of the skin is always fresh , It can maintain the state that makes it the best. When fibroblasts were treated with proteins produced from stem cells, the amount of 'collagen', a connective tissue produced by fibroblasts, increased more than 5 times and the proliferation of fibroblasts increased by more than 30%. Fibroblasts are cells that produce collagen that forms the dermal layer of the skin. When the amount of collagen is reduced, the skin elasticity is reduced and the wrinkles are increased. Stem cells are multipotent cells with ability to differentiate into cells such as bone, cartilage, ligament, fat, myocardium, and muscle in vivo as well as in vitro. Stem cells, which are multipotential cells, are used not only as a good model for the study of differentiation mechanism into each tissue cell but also in various cell therapy methods.

Since the stem cell culture fluid extract contains the above-mentioned growth factors, it can be used as a skin constituent cell, such as promoting fibroblast migration, activating effect, skin regeneration and antiaging effect, increasing collagen synthesis, inhibiting the activity of tyrosinase, inhibiting melanin synthesis, And a reduced follicular restoration effect can be expected.

The stem cell culture liquid extract of the present invention can be obtained by the method specified in U.S. Patent No. 6,153,432 (November 28, 2000). First, lipid stem cells are isolated from adipose tissue obtained through liposuction. When the adipose stem cells are adhered to the bottom of the culture vessel, the substrate medium is removed and the differentiation medium (DIFFERENTIATION MEDIA) is put into the culture medium. After incubation for 3 days, adipocyte media is added to differentiate into adipocytes. The stage of differentiation of adipose stem cells is the stage where the formation of small lipid droplets in the cytoplasm is started at the early stage of differentiation, the number of small lipid droplets is gradually increased, and the small lipid droplets are gradually merged to form large lipid droplets. , And when fully matured, one lipid droplet occupies the entire cytoplasm and the size of the cell gradually increases during the maturation process. In the step of obtaining such adipocyte-derived cells, the basic fibroblast growth factor (bFGF) and / or the epidermal growth factor (EGF) 100 ng / ml, and the resulting culture was used as a stem cell culture extract of the present invention.

The above-mentioned ginseng ginseng extract refers to an extract obtained by extracting ginseng ginseng. The ginseng ginseng has been conventionally used as an antidiabetic agent, anticancer agent, heart strengthening and blood pressure control, gastrointestinal function enhancement, It is known that it is effective for relieving stress, tanning effect, suppression of aging, radiation, defense, anemia and hematopoiesis, improving immune function and activity, antiinflammatory effect, improving weakness and so on. It is also said to circulate.

The Hydrolyzed Soy Protein is a hydrolyzate component of soybean protein obtained by acid, enzyme or other hydrolysis method. It provides conditioning to skin and hair, and it provides vital skin and healthy and vital hair care Help.

The composition according to the present invention is characterized in that the composition contains the hydrolized soy protein to improve the scalp penetration ability of the composition.

Since 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide is disclosed in detail in Korean Patent No. 10-1348006, the 4-pyrrolidine-2,6-diaminopyrimidine 1-oxide Is omitted.

The yeast of the yeast extract may be Saccharomyces cerevisiae, and yeasts of other kinds may also be used. Yeast contains a variety of amino acids such as arginine, glutamic acid, isoleucine, leucine, and valine, and plays a role in supplementing deficient proteins in skin and hair. Yeast also contains a variety of vitamins such as vitamin B1 (thiamine), vitamin B2 (riboflavin), pantothenic acid, and niacin, which provide nutrients to the skin and hair. The yeast extract is rich in amino acid content and is a good quality vegetable protein. It is highly effective in hair loss prevention, hair growth, and is rich in minerals and trace elements such as selenium and chromium, and is a complex of natural vitamin B group.

Accordingly, the yeast extract has an effect of strengthening hair roots and consequently preventing hair loss.

The above-mentioned Hwasungcho extract's active ingredients are contained in all the leaves, stems, and roots, and physiologically active substances including distinctive odors are used to help metabolism, cleanse blood, promote renal function, excrete inflammatory symptoms and toxins And has been widely used as a civilian medicine in China and Japan since ancient times more than 3,000 years ago.

It is used as a medicinal material with various effects. It is used as a medicinal material with various efficacies. Drink 40-50g of lobular lobules for a cold, and if you sweat, It is effective if you drink the lobules and bellflower roots in the cough, sputum, bronchitis, asthma, etc., and drink the juice of the lobulated leaves. In the case of insomnia and nervous breakdown, , Or put the raw leaves under the pillow. In fish and crab poisoning, 20 ~ 30g of the baby lobes are deeply melted, and when they are drunk, they have the characteristic of releasing quickly, which is useful for modern people suffering from diseases.

The ginseng extract is red ginseng, which is prepared by baking and drying the ginseng with a moisture content of 14% or less. The ginseng is maintained in a very solid form with a dark brown color by promoting the browning reaction during the manufacturing process. It is easier to store and transport by reducing the volume and weight by preventing the contamination of bacteria, fungi and microorganisms by moisture reduction through processing and drying than the condition of fresh ginseng containing about 75% moisture. The development of saponin quantitation method and quality control, which is the representative active ingredient of ginseng, suppressed the decomposition of saponin as much as possible during processing, and additionally produced saponin maltol, G-Rh2 and other active ingredients.

Although the ginseng extract contains a lot of carbohydrates such as starch, it contains ginseng saponin contained only in ginseng, antioxidant activity and polyacetylene which is a cancer cell growth inhibiting component, phenolic compound, (Gomisin-N, -A), an acidic peptide that acts like an insulin, and the like. In addition, the specific saponin (ginseng saponin) contained in ginseng typically exhibits a detoxifying action, an anti-fatigue action, an anti-inflammatory action, a central nerve inhibiting action, an anti-diabetic action, a platelet aggregation inhibiting action, a cancer cell proliferation inhibiting action, There is a lot of efficacy. And the ginseng in one room is the efficacy that the five days, heart, lungs, kidneys, spleen are raised, the spirit is stabilized, the disease which enters into the ovary is removed, the eyes are cleared, the body is lighter and longevity Based on this, it is used for the treatment and various clinical symptoms.

The above-mentioned di-panthenol promotes wound healing and has an excellent moisturizing effect.

The salicylic acid is an o-oxybenzoic acid having antipyretic and analgesic action. Therefore, the salicylic acid is used as a sodium salt or a calcium salt, and is also used for improving solubility, stability and pharmacological properties by binding salicylic acid to various drugs.

The bioten is a vitamin 8 that maintains and improves the health of the skin, helps prevent gray hair and hair loss, and is very good for hair loss as well as hair loss.

Zinc pyrithione is a kind of antimicrobial agent, and its effect of inhibiting growth of dandruff and its anti-inflammatory action are known.

The Niacinamide is water-soluble vitamin B3, which helps to maintain melanin transfer and maintain clean skin. That is, melamine is synthesized in the melanocyte located in the basement membrane and then transferred to keratinocyte through the melanosomes projected with melamine, and eventually melamine migrates to the surface of the skin. It inhibits metastasis. In addition, it improves oily skin and promotes collagen secretion by activating skin cells, thereby improving aging and preventing moisture loss and stimulating the microcirculation of the dermis to strengthen the skin barrier.

The Copper tripeptide-1 is excellent in skin regeneration ability, promotes wound healing, strengthens skin elasticity, increases subcutaneous fat layer to prevent skin aging, It prevents the generation of free radicals, which is the root cause of aging. It also functions to prevent aging by increasing the production of glycosaminoglycans.

The moromi mushroom extract of Morus alba Mori is a medicinal product made of Morusca mulberry (Morusca L.) or roots of the same plants. It has blood pressure lowering effect, diuretic action, anti-inflammatory action, antibacterial action and shrinkage, analgesia, Especially, it has excellent effect on skin moisturizing and whitening.

The henna extract has been used as a beauty material such as tattoos and hair dye in ancient Egypt, Middle East, Africa and India since thousands of years ago. It has antipyretic, astringent and antibiotic components and it can be used for headache, inflammation, burns, ulcers, Is also being used as a medicine to prevent the disease. As a hair dye, henna was first introduced to Europe and has been widely used since 1890 for henna hair dyeing and treatments.

In addition, the human adipose tissue stem cell culture extract extract is contained in an amount of 5 to 10 parts by weight based on 100 parts by weight of the composition, the extract is contained in an amount of 3 to 5 parts by weight, the hydrolyzed soy protein is 0.01 to 0.03 parts by weight, And the 4-pyrrolidine-2,6-diaminopyrimidine-1-oxide is preferably contained in an amount of 2 to 4 parts by weight, and the yeast extract, hyssop extract, green leaf extract, red ginseng extract, , Di-panthenol, salicylic acid, biotin, zinc pyruchate, niacinamide, capper tripeptide-1, mucus extract and henna extract are preferably contained in an amount of 0.01 to 5 parts by weight, can do. The composition may further contain at least one of ethanol, glycerin, 1,2-hexanediol, butyleneglycol, menthol, PEG-60 Hydrogenated Castor Oil, arginine, acrylate / C10-30 alkyl acrylate crosspolymer, allantoin, tocopheryl acetate, fragrance, adenosine, licorice extract, gossypium extract, Angelica gigantum extract, dimethyl sulfone and the like may be further included if necessary.

The composition according to the present invention can be used alone or as a mixture of two or more of the above active ingredients. When all of the active ingredients are used, hair loss prevention and hair growth promoting effects can be further improved. Especially, when hydrolized soy protein is used The composition is characterized in that the composition has improved scalp penetration.

First, the extract according to the present invention can be obtained by extracting and isolating from nature using an extraction and separation method known in the art, and the extract defined in the present invention is extracted with an appropriate solvent, For example, it includes both hot-water extract, polar solvent-soluble extract and non-polar solvent-soluble extract.

As the solvent, any solvent acceptable in the art may be used, and water or an organic solvent may be used. Examples of the solvent include purified water, methanol, ethanol, propanol, isopropanol, butanol, butylene glycol, acetone, ether, Various solvents such as benzene, chloroform, ethyl acetate, methylene chloride, hexane, and cyclohexane may be used alone or in combination. However, It does not.

As the extraction method, any one of the methods such as hot water extraction method, cold extraction method, reflux cooling extraction method, solvent extraction method, steam distillation method, ultrasonic extraction method, elution method and compression method can be selected and used. In addition, the desired extract may be further subjected to a conventional fractionation process or may be purified using a conventional purification method.

Therefore, the extract in the present invention is a concept including all the extract, fraction and purified product obtained in each step of extraction, fractionation or purification, and a diluted solution, a concentrate or a dried product thereof.

In one embodiment of the present invention, the composition for external application according to the present invention may further contain a surfactant, a cationic polymer and a conditioning component which are conventionally used in the art.

The surfactant may be selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyoxyethylene fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene polyoxypropylene block copolymers, glycerides, polyoxyethylene glycolated castor oil, (Hydrogenated) castor oil, a polyalkylene polyol trans esterification product, a hydroxyethyl alkylamine, a polyoxyethylene alkylamine, a polyoxyethylene alkylamine fatty acid ester, a glycero fatty acid ester, a polyoxyethylene fatty alcohol ester, And may be selected from the group consisting of polyoxyethylene alkylphenyl ether, alkylsulfonate, alkylbenzenesulfonate, alkylsulfate, alkylphosphate, tetraalkylammonium salt, trialkylbenzylammonium salt and alkyl betaine or a mixture thereof.

Preferably a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, and a polyoxyethylene glycolated (hydrogenated) castor oil, or a mixture thereof. The surfactant may be included in an amount of 3 to 40 parts by weight based on 100 parts by weight of the total composition.

Examples of the cationic polymer include, but are not limited to, polymeric quaternary ammonium salts of hydroxyethyl cellulose and guar hydroxypropyl triammonium chloride.

The amount of the cationic polymer may be 0.1 to 2.0 parts by weight and 0.1 to 0.5 parts by weight based on 100 parts by weight of the total composition. If the content of the cationic polymer is less than 0.1 part by weight, the above effect can not be expected. If the amount is more than 2.0 parts by weight, it is difficult to control the viscosity and excessively adheres to the hair.

The conditioning component may be selected from the group consisting of cyclomethicone, dimethicone (dimethylpolysiloxane), dimethicone copolyol, alkyl dimethicone polyol, silicone ester, fluorodymethicone, alkyl dimethicone, dimethicone copolyol amine, carboxy silicone, But are not limited to, silicones including esters, silicone resins, silicone phospholipids, amodimethicone, aminopropyldimethicone, and silicone quats. The content of the conditioning component may be 0.01 to 10.0 parts by weight and 1.5 to 2.0 parts by weight based on 100 parts by weight of the total composition. When the content of the conditioning component is less than 0.01 part by weight, it is difficult to expect a conditioning effect. When the content of the conditioning component is more than 10.0 parts by weight, quality deterioration due to destabilization of the formulation may be worried.

According to one embodiment of the present invention, the composition according to the present invention may further contain an appropriate amount of colorants, preservatives, sequestering agents and fragrances which are conventionally used in the art within the range of maintaining stability.

The composition according to an embodiment of the present invention may be a hair cleanser composition and may be a hair shampoo, a hair conditioner, a hair conditioner, a hair treatment, a hair tonic, a scarf treatment, a hair lotion, a hair cream, ≪ / RTI >

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings, in which a hairpin 10 (hereinafter referred to as a 'hair pack') comprising an external composition for preventing hair loss or for promoting growth of hair, Will be described in detail.

2 is a perspective view of a hair pack according to a preferred embodiment of the present invention. FIG. 3 is a perspective view of a hair pack according to a preferred embodiment of the present invention. A preferred hairpin 10 of the present invention comprises a hairpin body 100, a hairpin sheet 200, and a hairpin cover 300.

First, the hair pack body 100 is a flexible elastic material 110 having a silicone shape and is formed in a circular shape, i.e. hemispherical shape, like a human head shape, and a heat absorbing material 120 is stored therein.

The hair pack 10 according to the preferred embodiment of the present invention is formed of a flexible elastic material such as silicone such that the hair pack body 100 and the hair pack cover 300 are made of elastic material such as silicone, To the head 20 of the user and allows the user to press the hair pack 10 to easily absorb the hair restoration composition absorbed in the hair pack sheet 200 to the user's scalp as well as to provide the user with a scalp massage function .

Next, the endothermic material 120 used in the present invention is a substance that causes an endothermic reaction in the polymer gel, for example, an inorganic salt; Inorganic ammonium salts such as ammonium nitrate, ammonium sulfate, ammonium acid sulfate, ammonium phosphate, ammonium dihydrogen phosphate, ammonium metavanadate, ammonium chloride, ammonium bromide, and iodoammonium; Alkali metal salts such as sodium nitrate and potassium nitrate; Nitrate metal salts; And elements. Also preferably, the inorganic salt and urea are mixed in a weight ratio of about 1: 1. Of these, ammonium nitrate, ammonium chloride, ammonium bromide, ammonium sulfate or urea are preferred and particularly preferably ammonium nitrate and urea are mixed at the same weight ratio.

As the polymer resin forming the polymer gel containing the endothermic material and maintaining the cooling performance in the present invention, various kinds of superabsorbent materials and thickeners can be used. Examples thereof include starch, carboxymethylcellulose, carboxyethylcellulose, alkyl Acid, gelatin, starch-acrylic acid graft copolymer, maleic acid copolymer, vinyl acetate-acrylate copolymer, polyvinyl alcohol, and polyacrylic acid. Preferably, the polymer resin usable in the present invention is a hydrophilic polymer, for example, polyvinyl alcohol, polyacrylic acid or starch, and particularly preferably polyvinyl alcohol.

Examples of the crosslinking agent for the polymer resin in the present invention include aldehydes such as formaldehyde, acetaldehyde and glutaraldehyde, and acids such as sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid, , Magnesium chloride hexahydrate, sodium tetraborate decahydrate, sodium carbonate decahydrate, sodium carbonate tetrahydrate, sodium sulfate decahydrate, sodium phosphate decahydrate and the like.

Next, the hair pack sheet 200 provided in the hair pack 10 according to the preferred embodiment of the present invention is configured to be used according to the shape of the user's hair loss as shown in FIGS.

5, the hair pack sheet 200 includes a circular absorbent sheet corresponding to the shape of the lower end of the hair pack body 100, the composition being partitioned by hair loss portions of the head, An incision 210 is formed so as to enable the incision 210 to be made.

Accordingly, the user can cut and use the hair pack sheet 200 as shown in FIG. 5 in accordance with his / her hair loss pattern. This is because the sheet is not adhered to the unhairing area due to the unhairing hair composition on the unhairing area or the unhairing hair area, so that the user can cut and use the hair packing sheet 200 to prevent it to be.

In addition, it is intended to use a hair loss composition having a different composition ratio for each hair loss region.

That is, the hair removal composition includes a composition which is effective for suppressing male hormone and a hair loss composition that contains a large amount of composition having scalp nutrition and scalp stabilizing effect in a region where hair loss is not much progressed. This will be described in more detail below.

Next, referring to the hair pack cover 300, the hair pack cover 300 has a plate shape corresponding to the hair pack body 100 as shown in FIGS. 6 to 7, A partition wall 334 corresponding to the hair pack sheet 200 is formed on the inner surface of the insertion portion 310 where the hair pack body 100 is inserted into the outer portion of the hair pack sheet 200, Are provided for each compartment and a plurality of through holes 340 are provided for each compartment.

That is, the incised hair pack sheet 200 according to the user's hair loss pattern is inserted into the partition defined by the partition wall 334 in the hair pack cover 300, and the hair pack body 100 is inserted into the insertion portion 310, The hair pack 10 can be applied only to the user's hair loss region if the hair clip 10 is inserted into the space 320 formed in the hair removal unit.

Here, the hair pack sheet 200 may be provided in a form in which the composition is absorbed in advance. Preferably, the hair pack sheet 200 is placed in a partition defined by the partition wall 334 in the hair pack cover 300, It is preferable that the hair-loss prevention composition is applied to the hair-pack sheet 200 by using a coating device in which the composition is stored.

This is for the user to prevent the hair-loss preventing composition from being buried in the user's body when the hair pack sheet 200 is cut.

And two or three anti-depilating composition dispensing devices having different composition ratios of the anti-depilation composition are provided to the user, so that the user applies the anti-depilation composition to the hair pack sheet 200 according to his or her own hair loss progression pattern.

That is, as described above, the hair pack sheet corresponding to the region where the hair loss is much progressed is applied with a composition effective for suppressing the male hormone, and the hair pack sheet corresponding to the region where the hair loss is not much progressed has the effect of scalp nutrition and scalp stabilization So that a composition containing a large amount of the composition is applied and used.

Thus, the hair loss prevention composition applied to the hair pack 200 is transmitted to the user's scalp through the through hole 340 formed in the hair pack cover 300. When the user presses the flexible elastic hair pack 10, It is possible to deliver the composition for preventing hair loss to the scalp of the user.

Since the hair pack 10 includes the endothermic material 120, the user's scalp is heated to prevent the scalp from being irritated, thereby further enhancing the absorption effect of the scalp stabilizing and hair loss preventing composition.

In the massage, the microprojections 332 are formed on the outer surface of the hair pack cover 300 to further enhance the stimulation effect by the massage, thereby expanding the pores of the scalp to further promote absorption of the hair loss prevention composition.

Alternatively, as shown in the lower part of FIG. 7, the hair pack according to another preferred embodiment of the present invention may have a through hole 342 having a large diameter instead of the through hole 340 having a small diameter in the hair packing sheet 200 The incised hair pack sheet 200 is seated on the rim of the through hole so that the user's scalp surface and the seated hair pack sheet 200 are in direct contact with each other through the through hole 342, A protrusion 130 corresponding to the size and shape of the through hole 342 may be formed and the protrusion 132 may be formed outside the protrusion.

When the user places the hair pack 10 on the scalp and then pushes the hair pack body 100, the protrusions 130 of the hair pack body 100 and the protrusions 132 formed on the protrusions contact the user's scalp It is possible to further enhance the scalp absorption and the scalp massage effect of the hair restoration composition absorbed in the hair pack sheet 200 by pressing the contacting hair pack sheet 200.

The edge 220 of the hairpin sheet 200 may be formed with a cutout 220 to prevent incision of the other part of the hairpin sheet 200 when the incision is made, It is preferable that it is formed of a thick material (see Fig. 3).

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are for illustrative purpose only and that the scope of the present invention is not limited to these embodiments.

Manufacturing example  1: Preparation of goat ginseng extract

9.5 kg of a mixed solution of butylen glycol and purified water (weight ratio 30:70) was added to 500 g of goat mountain ginseng, and the mixture was immersed at room temperature for 10 days and filtered through a 0.22 μm filter membrane to prepare an extract.

Manufacturing example  2: Preparation of composition for preventing hair loss or for promoting hair growth

10% by weight of human adipose stem cell culture extract, 3% by weight of ginseng root extract, 0.02% by weight of hydrolized soy protein, 2% by weight of 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide, yeast extract 3 1% by weight of Hwasung extract, 1% by weight of green leaf extract, 2% by weight of red ginseng extract, 2% by weight of ginseng extract, 0.2% by weight of di-panthenol, 0.2% by weight of salicylic acid, 0.06% by weight of biotin, , 0.1% by weight of niacinamide, 0.3% by weight of niacinamide, 0.06% by weight of capric tripeptide-1, 2% by weight of Eucalyptus extract, 2% by weight of wenna extract, 5% by weight of ethanol, 10 weight% of butylene glycol, 0.3 weight% of menthol, 5.5 weight% of a fat-60 hydrogenated castor oil, 3 weight% of arginine, 2 weight% of acrylate / C10-30 alkyl acrylate crosspolymer, , 3% by weight of tocopheryl acetate, 0.8% by weight of fragrance, The composition, including the remaining amount of purified water with 2% by weight, 5% by weight of licorice root extract, Sophora extract, 5% by weight, 3% by weight angelica root extract, and 0.2% by weight of dimethyl sulfone were prepared.

Manufacturing example  3: Endothermic  Produce

First, 10 g of PVA (Mw 89,000-120, 000) and 50 g of urea were added to 40 g of water in a 100 ml glass beaker and dissolved at 70 캜 with stirring so as to be mixed well. The PVA polymer material was completely dissolved and then slowly cooled to room temperature while stirring. To this was added 1 g of glutaraldehyde and 1 g of phosphoric acid, which were PVA as an edifying agent, and stirred sufficiently. The solution was allowed to stand at room temperature for one day to form a polymer gel. The temperature of the polymer gel was measured and recorded. The polymer gel thus formed has elasticity and elasticity while containing endothermic material.

Experimental Example  1: Acute Toxicity Experiment

The mice were divided into 36 groups each consisting of 25 ± 5 g ICR mice (for experimental animals) and 235 ± 10 g SPF Sprague Dawley (Biogenomics) rats of 235 ± 10 g. Were administered intraperitoneally at a dose of 20 mg / kg, 10 mg / kg and 1 mg / kg, respectively, and then observed for toxicity for 24 hours.

As a result of the experiment, we could not observe any cases of death in all of the 36 groups, and we could not find any symptoms except for the control group in weight gain and feed intake. Therefore, it was confirmed that the anti-depilation composition of the present invention is a safe drug.

Experimental Example  2: Hair growth experiment

Five - week - old mice (C57BL, female) were sacrificed from the central experimental animals. After about one week of purifying period, general health condition was observed and only healthy animals were used for the test. Experiments were carried out in an animal room where conditions of KFDA were met. Feeds for mice (Samyang feed) and water were provided freely. The animals were kept at 23 3 ° C and 50% relative humidity for 12 hours day and night.

All animal experiments were conducted according to the Ethics Guidelines of the Korea University Animal Experimental Ethics Committee (KUIACUC-2014015-2).

In order to evaluate the hair growth efficacy, 6-week old hairy hairs with pink color on the dorsal skin were used. Using an Animal Clipper, the hair of the rats' backs was carefully shaved, and a 0.2 ml sample was thoroughly applied using a brush on the shaved area, followed by massage for about 3 minutes, followed by thorough rinsing with distilled water. Sample treatment was performed once a day and observed in the positive control group for 3 weeks in which the hair growth was completely covered.

The treated samples were prepared by mixing 10% by weight (Example 1) and 5% by weight (Example 2) of the composition prepared in Preparation Example 2 with a solvent control (saline) and saline, 5.0% by weight of minoxidil as a positive control, .

The evaluation criteria were anesthetized with pentobarbital at 4 days, 7 days, 10 days and 14 days after the start of the test, and photographs were taken of the development of hairs. The results are shown in FIG. 8 . The results of the hair growth were determined according to the following Table 1, and the evaluation results are shown in Table 2 below.

Degree of hair growth Scoring Judgment 0 to 20% - No efficacy 20 to 50% A weak 50 to 70% AA Good More than 70% AAA Excellent

Elapsed days after application evaluation Solvent control Example 1
(10% by weight) Example 2
(5% by weight) Minoxidil
(5.0% by weight) 4 days

Degree of hair growth 10 13 10 10 Scoring - - - - Judgment no effect no effect no effect no effect 7 days

Degree of hair growth 19 53 36 56 Scoring - AA A AA Judgment no effect Good weak Good 10 days

Degree of hair growth 36 63 60 68 Scoring A AA AA AA Judgment weak Good Good Good 14 days

Degree of hair growth 50 83 75 89 Scoring A AAA AAA AAA Judgment Good Excellent Excellent Excellent

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. It is clear that the present invention can be suitably modified and applied in the same manner. Therefore, the above description does not limit the scope of the present invention, which is defined by the limitations of the following claims.

10: hair pack; 20: Tofu
100: a hair pack main body part; 110, 330: Elastic flexible material in silicone form
120: endothermic material; 130: protrusion
132: projection; 200: Hair Pack Sheet
210: Section improvement; 220:
300: hair pack cover; 310:
320: space portion; 332:
334: bulkhead; 340, 342: through hole

Claims (9)

A method for preventing or treating alopecia of the scalp, comprising the step of culturing the human adult stem cell culture liquid, extracting the ginseng root ginseng, hydrolyzed soy protein, and 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide A composition for external application for promoting hair growth. The method according to claim 1, wherein the extract is selected from the group consisting of yeast extract, Houttuynia cordata extract, Liliaceae extract, Red ginseng extract, Ginseng extract, Dipanthenol, Salicylic acid, Biotin, Zinc pyrichion, Niacinamide, Cappert peptide- The composition for preventing hair loss or promoting hair growth according to claim 1, [2] The composition according to claim 1, wherein the human adipose tissue stem cell culture extract is contained in an amount of 5 to 10 parts by weight based on 100 parts by weight of the total composition. [3] The composition for preventing hair loss or promoting hair growth according to claim 1, wherein the ginseng extract is contained in an amount of 3 to 5 parts by weight based on 100 parts by weight of the total composition. [2] The composition according to claim 1, wherein the composition is selected from the group consisting of hair shampoo, hair conditioner, hair conditioner, hair treatment, hair tonic, scalp treatment, hair lotion, hair cream, hair lotion or general ointment A composition for preventing hair loss or promoting hair growth, wherein the effect of scalp penetration is enhanced. A hair-pack main body having a silicone-like resilient flexible material and having a round shape having a human head shape and a heat absorbing material stored therein;
A circular absorbent sheet corresponding to a shape of a lower end portion of the body part of the hair pack, wherein the composition according to any one of claims 1 to 5 is contained and is divided into head hair loss parts, A hairpin sheet; And
The insertion portion is formed in a plate shape corresponding to the shape of the body of the hair pack, and is formed of a flexible material having elasticity of silicon type. The insertion portion is inserted into the outer side to insert the body of the hair pack. The hair pack according to any one of claims 1 to 3, wherein the hair pack includes a plurality of through holes formed in each of the compartments. 7. The hair pack according to claim 6, wherein a plurality of fine protrusions are formed on an outer surface of the hair pack cover. The hair pack according to claim 6, wherein the endothermic material comprises a cross-linking agent of an endothermic material, a polymer resin, and a polymer resin mixed with at least two members selected from the group consisting of urea, an inorganic salt, an inorganic ammonium salt and an alkali metal salt. [7] The hair pack according to claim 6, wherein the composition ratio of the composition has a different composition ratio according to the compartment of the hair pack sheet.

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