KR20110075626A - Composition for promoting hair growth comprising fermented oriental medicine extract - Google Patents

Abstract

PURPOSE: A trichogenous composition containing natural product fermentation extract is provided to enhance skin regeneration ability and to ensure persistence. CONSTITUTION: A natural product fermentation extract is prepared by mixing Pinus densifl, Undaria pinnatifida, Rhynchosia Nolubilis, or Zanthoxyloum schinifolium, extracting, inoculating Lactobacillus or yeast, and fermenting at 30-50°C for 24-72 hours. The Lactobacillus is Lactobacillus sp., Streptococcus sp., Pediococcus sp., Leuconostoc sp., or Bifidobacterium sp. A trichogenous composition contains the natural product fermentation extract as an active ingredient.

Description

Composition for promoting hair growth comprising fermented oriental medicine extract}

The present invention relates to a hair regrowth composition comprising a natural fermented extract as an active ingredient, and more particularly, a composite fermented extract of pine needles, seaweed, soybeans, and cabbage derived from natural products as an active ingredient, and prevents hair loss, promotes hair growth and hair growth. To a hair regrowth composition.

Alopecia is caused by excessive sebum production due to circulatory problems such as endocrine system disorders, autonomic nervous system disorders, and blood circulation disorders, physical factors such as malnutrition of hair roots, allergies and bacterial infections, genetic factors such as the effects of male hormones, various pollution and processing. Food, alcohol, shampoo, soap, mousse, hair gel, hairspray, perm, dye, hair dryer, environmental factors such as the use of modern people often stress excessive stress, social factors, aging, etc. It is known to appear.

In addition, in recent years, regardless of gender and age, hair loss is increasing, and the starting age of hair loss is gradually decreasing. Topical coatings, oral dosages, dietary supplements, gene transplants, hair transplants, and the like, are being treated as hair loss.

However, these methods have a limited scope of use, prevent continuous hair loss, have a temporary effect on drug treatment, rather accelerate the production of scalp or sebum, and especially adversely affect heart disease. There was a lung with accompanying side effects.

After all, the present invention was devised to solve the above problems, the main object of the present invention is to prevent hair loss and at the same time the new hair comes up, the thin hair is thick, once the hair has a normal hair cycle It is to provide a natural product fermentation extract and a hair regrowth composition comprising the natural product fermentation extract as an active ingredient.

In order to achieve the above object, the present invention provides a natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effect.

In the present invention, the natural product fermentation extract is mixed with one or more selected from pine needles, wakame, soybeans, and pepper and extracted with water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, the lactic acid bacteria or It is characterized in that the fermentation is made by inoculating one or more of the yeast, wherein the pine needles: seaweed: soybean: acidic is preferably mixed in a weight ratio of 10 to 50: 10 to 50: 30 to 70: 1 to 10.

The present invention also provides a hair restorer composition comprising the natural product fermentation extract as an active ingredient.

For reference, this application was performed as a technical support project of Gyeongbuk Marine Bioindustry Research Institute.

The hair regrowth composition comprising the natural fermentation extract of the present invention inhibits the activation of dihydrotestosterone (DHT) that causes hair loss, activates growth factors and WNTs, which are neurotransmitters, and dermal papilla cells and skin cells. By promoting the activity of the back and can fundamentally treat and prevent hair loss, and also promotes hair growth and has the effect of hair growth.

As a result, the hair regrowth composition according to the present invention enables fundamental treatment that focuses on increasing the inherent regenerative ability of the skin rather than temporarily improving hair loss. In addition, skin disease and hair loss treatment can be performed at the same time, it can have a lasting effect.

In addition, the natural product fermentation extract of the present invention has scalp itching and anti-dandruff effect can be usefully used in scalp cleaners, dandruff treatments and the like.

Hereinafter, the present invention will be described in detail.

The present invention provides a natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effects derived from natural products.

The natural product fermentation extract is preferably at least one selected from pine needles, seaweed, soybeans and sancho, and after powdering the selected sample, about 1 to 20 times the weight of the sample, preferably 5 to 15 times the volume of water , A lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, preferably stirring and extracting at 35 to 100 ° C., preferably at 95 to 100 ° C. for about 0.1 to 48 hours, preferably 1 to 24 hours, and hot water extraction. By using extraction methods such as cold extraction, warm extraction, reflux cooling extraction or ultrasonic extraction, the extract obtained after hot water extraction is preferably filtered, concentrated under reduced pressure or dried to obtain an extract.

At this time, the pine needles, wakame, soybeans and sancho each shows the optimum effect when used in a mixture of 10 to 50: 10 to 50: 30 to 70: 1 to 10 by weight ratio.

The pine needles used in the present invention ( Pinus densifl ) contains a large amount of ascorbic acid (vitamin C) and vitamins A, B, K, bitter tastes , flavonoids, anthocyanin, and 7-12% resin (rosin) , 5% of tannins, carbohydrates, essential oils (0.13 ~ 1.3% in the leaves, 0.36% in the bud leaves, 0.2 ~ 0.9% in annual branches) and the like. In addition, there are 24 kinds of amino acids contained in red pine leaves and rich in iron, and 19 kinds of amino acids composed of proteins in the genus were also identified.

In addition to pine needles, all pines release waste products from the body, such as alcohol and esters, promote metabolism, phenolic compounds, kinins, terpentins, vitamins A and C, and chlorotyl. have.

Seaweed seaweed ( Undaria pinnatifida ) is a brown algae, an alkaline food, also called annual sea cucumber or photosensitive, belonging to the balsam family. According to modern pharmacological studies, many nutrients such as iodine (I), calcium (Ca), vitamin B, B12, B2, C, amino acids, potassium (K), cobalt (Co), fluorine (F), carotene and protein Iodine, especially in seaweed, is known to prevent thyroid edema and to prevent hair from falling out.

There are about 50 varieties of soybeans, and there are 22 varieties of black soybeans, but in the present invention, black soybeans (black soybeans), rats with very small seeds (Rhynchosia Nolubilis), or / and Seoryae (Sokcheong) Use Soybeans are rich in protein, minerals such as potassium (K), calcium (Ca) and iron (Fe) and vitamin B. They are excellent in detoxification and contain natural ingredients similar to female hormones, which are effective in preventing osteoporosis. .

In addition, black soybeans have been reported to inhibit the action of 5-alpha-reductase, a cause of hair loss, and lower the concentration of active male hormone (DHT).

Sancho (scientific name: Zanthoxyloum schinifolium ) is also known as cheoncho in oriental medicine. It has a hot taste and warm nature, which warms up the inside, cools down the energy and humidity, and relieves pain. Sancho contains 7% essential oils, including geraniol, limonene, and cumic alcohol. Essential oils extracted from the seeds of the Japanese herb have local anesthesia and analgesic action, and antibacterial action has an inhibitory effect on Escherichia coli, lysiobacteria, cocci, diphtheria bacteria, Staphylococcus aureus, dermatophytes.

These sanchos are used for industrial, wheat, and medicinal purposes. In folk medicine, the fruit, the bark and the leaves are dried and powdered, kneaded with flour and candles and spread on a sturdy paper or cloth. Hemorrhoids are effective to wash any part of the sancho with decoction water, the root is burned by burning fire (燒 末) to write, drinking decoction to stop headaches and cough, and apply to the scalp to prevent hair loss.

In addition, the 'extract' in the present invention includes all of the extract, purified, diluent, concentrate, and dried.

Extract obtained by the above method is preferably inoculated with at least one of lactic acid bacteria and yeast fermentation for 24 to 72 hours at 30 ~ 50 ℃.

The lactic acid bacterium usable in the present invention is Lactobacillus sp., Streptococcus sp., Pediococcus sp., Pediococcus sp., Leukonost sp. And Bifidobacterium sp. Can be one or more strains selected from the group consisting of Bifidobacterium sp. In addition, the yeast includes Saccharomyces sereviciae , Saccharomyces rouxii , Saccharomyces oviformis , Saccharomyces steineri Etc. are included. Preferably, Lactobacillus paracasei may be used as the lactic acid bacterium.

However, the type of the strain or yeast is selected in consideration of the human stability and fermentation power, so that the composition according to the present invention is applied directly to the human body in the form of external preparations for skin, etc., used in the art as long as human stability and fermentation power are recognized. Any strain or yeast may be used, the present invention is not limited to the type of lactic acid bacteria and yeast.

In addition, the term 'hair loss' includes all hair loss classified in the art except for hair loss (rebound) alopecia, preferably, alopecia areata, male-type hair loss, general hair loss, female hair loss, pediatric hair loss, adolescent hair loss, It refers to any one or more of hair loss caused by drug hair loss, seborrheic hair loss accompanying scalp skin diseases such as seborrheic dermatitis or psoriasis.

The present invention also provides a hair restorer composition comprising the natural product fermentation extract as an active ingredient.

The hair regrowth composition of the present invention may include the natural fermented extract in any amount within a range that does not have toxicity to the human body depending on the degree of symptoms or use of hair loss, specifically 0.001 to 99.99 weight based on the total weight of the composition It may be included in%, preferably contained in 0.1 to 50% by weight.

The composition of the present invention further contains a pharmaceutically or cosmetically acceptable carrier and is a conventional formulation of creams, lotions, tonics, sprays, aerosols, oils, solutions, suspensions, gels, ointments, emulsions, sesame seeds, pastes and the like. It can be prepared as. The composition of this invention contains a conventional base, and the other component generally used as a pharmaceutical or cosmetic raw material can be mix | blended suitably as needed.

The base of the composition of the present invention can be used as long as it is commonly used, such as purified water, mineral water, ethanol, glycerin, squalene, 1,3-propylene glycol, 1,3-butylene glycol, castor oil, Tsubaki oil and liquid petrolatum. Examples of other components to be incorporated into the compositions of the present invention include, but are not limited to, surfactants, emulsifiers, thickeners, preservatives (eg, methyl paraoxybenzoate), antioxidants, fragrances, and the like.

In addition to the above components, the composition of the present invention may include components that may serve to supply nutrients to hair follicles or hair growth promoting auxiliary components that are commonly used. For example, vitamins, amino acids, animal and vegetable oils, sodium chloride And the like, but are not limited thereto. These amounts are preferably added at 0.0001 to 10% by weight, preferably 0.01 to 1% by weight of the total composition. In this case, the vitamins include all but not limited to vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, biotin H (vitamin H), and the like, amino acids The class includes, but is not limited to, waveguide. In addition, animal and vegetable oils include, but are not limited to, horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, germ oil, and the like.

The composition of the present invention can be used by a method such as direct application or scattering on hair or scalp. In the present invention, the term "hair" includes hair follicles and hair follicles of hair, hair and eyelashes, and eyelashes, beards, armpits, pubic hair, and all parts having hair roots and hair follicles throughout the body. Accordingly, the present invention provides hair tonics, hair lotions, hair creams, hair sprays, hair mousses, hair gels, hair conditioners, hair shampoos, hair rinses, hair packs, hair treatments, eyebrow regrowths, eyelash regrowths or eyelash nutrients, or pets. It can be used as a shampoo and pet rinse.

The dose of the composition according to the present invention should be appropriately determined in consideration of sex, age, alopecia, hair condition and the like. Preferably it can be applied 1 to 5 times 3 ~ 15 추출물 1 day extract based on the adult.

When the hair regrowth composition of the present invention is applied to a male hair loss patient, which is said to be the most refractory, hair loss becomes significantly reduced after 1 to 8 weeks of thickening, and after 8 to 12 weeks, hairiness starts to appear, and 12 months after application Since then, it has returned to the normal level.

In addition, the bactericidal effect against dandruff bacteria seborrheic dermatitis was excellent, and when applied to a patient with seborrheic alopecia, it was confirmed that after 3 months, the hair loss improvement and complete hair loss. Therefore, the composition of the present invention can be used for hair loss preventing agent, hair growth promoting agent, hair growth agent, scalp cleaner, dandruff treatment agent and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

Example 1. Preparation of natural product fermented extract

After drying commercially available pine needles, seaweed, soybeans, and peppers, each powdered and mixed in a weight ratio of 1: 1: 7: 1, 500 g of the mixed powder was added, and 6 L of water was added thereto. Extraction was performed at 95-100 ° C. for 24 hours.

The extract was sterilized after filtration, and the sterilized extract was added with lactic acid bacteria ( Lactobacillus paracasei KW3110) at a concentration of 10 mg of strain per 100 mg of extract, followed by fermentation for 72 hours (3 days) while maintaining 35 to 40 ° C. An extract was prepared.

Experimental Example 1

To 25 people with severe hair loss symptoms shampoo once a day and then towel-drying, the natural product fermented extract prepared in Example 1 was applied evenly to the scalp with a hair loss to 9 ~ 15 골 evenly massage method in the first three months After more than 1 year of use, the results were observed.

As shown in Figure 1 to 6, hair loss was confirmed in all subjects significantly reduced hair loss, there was no skin irritation or side effects during the experiment.

As described above, specific portions of the contents of the present invention have been described in detail, and for those skilled in the art, these specific techniques are merely preferred embodiments, and the scope of the present invention is not limited thereto. Will be obvious. Thus, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

1 is a photograph showing the state before and 15 months after using the natural product fermentation extract of the present invention to test subjects with androgenetic alopecia.

Figure 2 is a photograph showing the state before and after 3 months of use of the natural product fermentation extract of the present invention to the test subject with seborrheic alopecia.

Figure 3 is a photograph showing the state before and 10 months after using the natural product fermentation extract of the present invention to test subjects with gynecomastia.

Figure 4 is a photograph showing the state before and 10 months after using the natural product fermentation extract of the present invention to test subjects with alopecia areata.

Figure 5 is a photograph showing the state before and 12 months after using the natural product fermentation extract of the present invention to test subjects with systemic hair loss.

Figure 6 is a photograph showing the condition before and after the use of the natural product fermented extract of the present invention (A) and 5, 6 and 12 months after the use of (B) to test subjects with hair loss.

Claims (5)

Natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effect. The method of claim 1, The natural product fermentation extract is prepared by mixing one or more selected from pine needles, seaweed, soybeans and acid, and then inoculating one or more of lactic acid bacteria and yeast in the extract is fermented for 24 to 72 hours at 30 ~ 50 ℃ Characterized in natural product fermented extract. 3. The method of claim 2, The lactobacillus is Lactobacillus sp., Lactobacillus sp., Streptococcus sp., Pediococcus sp., Pediococcus sp., Leuconostoc sp. Natural product fermentation extract, characterized in that at least one strain selected from the group consisting of Bifidobacterium sp. Hair repellent composition comprising the natural product fermented extract of any one of claims 1 to 3. The method of claim 4, wherein The composition is a hair loss composition, characterized in that is formulated as a hair loss preventing agent, hair growth promoting agent, hair growth agent, scalp cleaner or dandruff treatment agent.

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