KR20110075626A - Composition for promoting hair growth comprising fermented oriental medicine extract - Google Patents

Composition for promoting hair growth comprising fermented oriental medicine extract Download PDF

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KR20110075626A
KR20110075626A KR1020090132124A KR20090132124A KR20110075626A KR 20110075626 A KR20110075626 A KR 20110075626A KR 1020090132124 A KR1020090132124 A KR 1020090132124A KR 20090132124 A KR20090132124 A KR 20090132124A KR 20110075626 A KR20110075626 A KR 20110075626A
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hair
natural product
extract
composition
hair loss
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KR101196523B1 (en
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김무영
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(주) 젠셀
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755Gymnosperms [Coniferophyta]
    • A61K8/9767Pinaceae [Pine family], e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02Algae
    • A61K36/03Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/853Lactobacillus

Abstract

PURPOSE: A trichogenous composition containing natural product fermentation extract is provided to enhance skin regeneration ability and to ensure persistence. CONSTITUTION: A natural product fermentation extract is prepared by mixing Pinus densifl, Undaria pinnatifida, Rhynchosia Nolubilis, or Zanthoxyloum schinifolium, extracting, inoculating Lactobacillus or yeast, and fermenting at 30-50°C for 24-72 hours. The Lactobacillus is Lactobacillus sp., Streptococcus sp., Pediococcus sp., Leuconostoc sp., or Bifidobacterium sp. A trichogenous composition contains the natural product fermentation extract as an active ingredient.

Description

천연물 발효 추출물을 유효성분으로 하는 발모제 조성물{Composition for promoting hair growth comprising fermented oriental medicine extract}Composition for promoting hair growth comprising fermented oriental medicine extract}

본 발명은 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물에 관한 것으로, 더욱 상세하게는 천연물에서 유래한 솔잎, 미역, 콩, 산초의 복합 발효 추출물을 유효성분으로 하고 탈모방지, 발모촉진 및 육모 효과가 있는 발모제 조성물에 관한 것이다.The present invention relates to a hair regrowth composition comprising a natural fermented extract as an active ingredient, and more particularly, a composite fermented extract of pine needles, seaweed, soybeans, and cabbage derived from natural products as an active ingredient, and prevents hair loss, promotes hair growth and hair growth. To a hair regrowth composition.

탈모증은 내분비계 이상, 자율신경계 이상, 혈액순환장애 등 순환계 이상에 의한 과도한 피지생성, 모근의 영양결핍, 알레르기, 세균감염 등의 신체적 요인, 남성 호르몬의 영향 등의 유전적 요인, 각종 공해, 가공식품이 주류인 음식물, 샴푸, 비누, 무스, 헤어젤, 헤어스프레이, 퍼머, 염색, 헤어드라이어의 사용 등 환경적 요인 및 과도한 스트레스를 자주 받는 현대인의 정신적, 사회적 요인, 노화 등이 복합적으로 작용하여 나타나는 것으로 알려져 있다.Alopecia is caused by excessive sebum production due to circulatory problems such as endocrine system disorders, autonomic nervous system disorders, and blood circulation disorders, physical factors such as malnutrition of hair roots, allergies and bacterial infections, genetic factors such as the effects of male hormones, various pollution and processing. Food, alcohol, shampoo, soap, mousse, hair gel, hairspray, perm, dye, hair dryer, environmental factors such as the use of modern people often stress excessive stress, social factors, aging, etc. It is known to appear.

또한, 최근에는 남녀노소를 불문하고 탈모 현상이 증가하고 있을 뿐만 탈모의 시작 연령이 점차 낮아지고 있다. 이러한 탈모 현상의 치료 방법으로는 국소 도포제, 경구 복용제, 건강보조식품, 유전자 이식 수술이나 모발 이식 수술 등의 방 법이 시행되고 있다.In addition, in recent years, regardless of gender and age, hair loss is increasing, and the starting age of hair loss is gradually decreasing. Topical coatings, oral dosages, dietary supplements, gene transplants, hair transplants, and the like, are being treated as hair loss.

그러나, 상기와 같은 방법들은 사용범위가 한정되어 있고, 지속적인 탈모 방지가 이루어지지 않으며, 약물 치료의 효과도 일시적이고, 두피 혹은 피지의 생성을 오히려 가속화시키며, 특히 심장질환자에게는 나쁜 영향을 미치는 등의 부작용을 수반하는 폐단이 있었다.However, these methods have a limited scope of use, prevent continuous hair loss, have a temporary effect on drug treatment, rather accelerate the production of scalp or sebum, and especially adversely affect heart disease. There was a lung with accompanying side effects.

결국, 본 발명은 상기와 같은 문제점을 해결하기 위하여 안출된 것으로, 본 발명의 주된 목적은 탈모를 방지함과 동시에 새로운 모발이 올라오고, 가는 모발이 굵어지며, 한번 나온 모발은 정상헤어 사이클을 갖는 천연물 발효 추출물 및 상기 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물을 제공하는데 있다.After all, the present invention was devised to solve the above problems, the main object of the present invention is to prevent hair loss and at the same time the new hair comes up, the thin hair is thick, once the hair has a normal hair cycle It is to provide a natural product fermentation extract and a hair regrowth composition comprising the natural product fermentation extract as an active ingredient.

상기 목적을 달성하기 위하여, 본 발명은 탈모방지, 발모촉진 및 육모 효과를 가지는 천연물 발효 추출물 제공한다.In order to achieve the above object, the present invention provides a natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effect.

본 발명에 있어서, 상기 천연물 발효 추출물은 솔잎, 미역, 콩, 및 산초에서 선택되는 1종 이상을 혼합하여 물, 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합용매로 추출한 후, 그 추출물에 젖산균 또는 효모 중 하나 이상을 접종하여 발효시켜 제조되는 것을 특징으로 하며, 이때 상기 솔잎 : 미역 : 콩 : 산초는 각각 10~50 : 10~50 : 30~70 : 1~10의 중량비로 혼합하는 것이 좋다. In the present invention, the natural product fermentation extract is mixed with one or more selected from pine needles, wakame, soybeans, and pepper and extracted with water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, the lactic acid bacteria or It is characterized in that the fermentation is made by inoculating one or more of the yeast, wherein the pine needles: seaweed: soybean: acidic is preferably mixed in a weight ratio of 10 to 50: 10 to 50: 30 to 70: 1 to 10.

또한, 본 발명은 상기 천연물 발효 추출물을 유효성분으로 하는 발모제 조성 물을 제공한다.The present invention also provides a hair restorer composition comprising the natural product fermentation extract as an active ingredient.

참고로, 본 출원은 경북해양바이오산업연구원의 기술지원사업으로 수행되었다.For reference, this application was performed as a technical support project of Gyeongbuk Marine Bioindustry Research Institute.

본 발명의 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물은 탈모를 일으키는 디하이드로테스토스테론(DHT)의 활성화를 저해하고, 성장인자(growth factor)와 신경전달물질인 WNT를 활성화하며, 모유두세포와 피부세포 등의 활성을 촉진하여 근본적으로 탈모를 치료 및 방지할 수 있을 뿐더러 발모를 촉진하고 육모의 효과를 갖는다.The hair regrowth composition comprising the natural fermentation extract of the present invention inhibits the activation of dihydrotestosterone (DHT) that causes hair loss, activates growth factors and WNTs, which are neurotransmitters, and dermal papilla cells and skin cells. By promoting the activity of the back and can fundamentally treat and prevent hair loss, and also promotes hair growth and has the effect of hair growth.

그 결과, 본 발명에 따른 발모제 조성물은 탈모를 일시적으로 개선해 주는 것이 아닌 피부가 갖고 있는 고유의 재생 능력을 증가시키는 데 중점을 두는 근본적 치료가 가능하다. 또한, 피부질환과 탈모치료가 동시에 가능하고, 지속적인 효과를 나타낼 수 있다. As a result, the hair regrowth composition according to the present invention enables fundamental treatment that focuses on increasing the inherent regenerative ability of the skin rather than temporarily improving hair loss. In addition, skin disease and hair loss treatment can be performed at the same time, it can have a lasting effect.

또한, 본 발명의 천연물 발효 추출물은 두피가려움과 비듬 억제 효과가 있으므로 두피세정제, 비듬치료제 등에도 유용하게 사용될 수 있다. In addition, the natural product fermentation extract of the present invention has scalp itching and anti-dandruff effect can be usefully used in scalp cleaners, dandruff treatments and the like.

이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 천연물에서 유래한 탈모방지, 발모촉진 및 육모 효과를 가지는 천연물 발효 추출물 제공을 제공한다.The present invention provides a natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effects derived from natural products.

상기 천연물 발효 추출물은 솔잎, 미역, 콩 및 산초에서 선택되는 1종 이상 인 것이 바람직하며, 선택된 시료를 분말화 한 후, 시료 중량의 약 1 내지 20배, 바람직하게는 5 내지 15배 부피의 물, 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합용매, 바람직하게는 물로 35 내지 100℃, 바람직하게는 95 내지 100℃에서 약 0.1 내지 48시간, 바람직하게는 1 내지 24시간 동안 교반추출, 열수추출, 냉침추출, 가온추출, 환류냉각추출 또는 초음파추출 등의 추출방법을 사용하여, 바람직하게는 열수추출한 후 수득한 추출액을 여과, 감압농축 또는 건조하여 추출물을 수득할 수 있다.The natural product fermentation extract is preferably at least one selected from pine needles, seaweed, soybeans and sancho, and after powdering the selected sample, about 1 to 20 times the weight of the sample, preferably 5 to 15 times the volume of water , A lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, preferably stirring and extracting at 35 to 100 ° C., preferably at 95 to 100 ° C. for about 0.1 to 48 hours, preferably 1 to 24 hours, and hot water extraction. By using extraction methods such as cold extraction, warm extraction, reflux cooling extraction or ultrasonic extraction, the extract obtained after hot water extraction is preferably filtered, concentrated under reduced pressure or dried to obtain an extract.

이때, 상기 솔잎, 미역, 콩 및 산초는 각각 10~50 : 10~50 : 30~70 : 1~10의 중량비로 혼합하여 사용할 때 최적의 효과를 나타낸다. At this time, the pine needles, wakame, soybeans and sancho each shows the optimum effect when used in a mixture of 10 to 50: 10 to 50: 30 to 70: 1 to 10 by weight ratio.

본 발명에서 사용하는 솔잎(학명: Pinus densifl)에는 다량의 아스코르빈산(비타민 C)과 비타민 A, B, K, 쓴맛을 내는 고미성 물질, 플라보노이드, 안토시안, 7~12%의 수지(송진), 5% 정도의 탄닌질, 탄수화물, 정유(정유 함량은 잎에 0.13~1.3%, 싹잎에 0.36%, 1년생 가지에 0.2~0.9%) 등이 함유되어 있다. 또한, 철분도 풍부하고 적송잎에 함유된 아미노산은 24종으로, 이 속에 단백질로 구성된 아미노산 19종류도 확인되었다.The pine needles used in the present invention ( Pinus densifl ) contains a large amount of ascorbic acid (vitamin C) and vitamins A, B, K, bitter tastes , flavonoids, anthocyanin, and 7-12% resin (rosin) , 5% of tannins, carbohydrates, essential oils (0.13 ~ 1.3% in the leaves, 0.36% in the bud leaves, 0.2 ~ 0.9% in annual branches) and the like. In addition, there are 24 kinds of amino acids contained in red pine leaves and rich in iron, and 19 kinds of amino acids composed of proteins in the genus were also identified.

솔잎 성분 외에 소나무 전체에는 알코올, 에스테르 등 체내의 노폐물을 배출시키고, 선진대사를 촉진하는 성분, 페놀 화합물, 키닌, 테르펜틴, 비타민 A 와 C, 클로틸을 주성분으로 하는 성분과 글리코기닌, 아피에틴산도 있다.In addition to pine needles, all pines release waste products from the body, such as alcohol and esters, promote metabolism, phenolic compounds, kinins, terpentins, vitamins A and C, and chlorotyl. have.

해조류인 미역(학명: Undaria pinnatifida)은 갈조류로서, 곤포과에 속하는 일년생의 온대성 해채 또는 감광이라고도 불리는 알카리성 식품이다. 현대 약리학 연구 발표에 따르면 요오드(I), 칼슘(Ca), 비타민 B, B12, B2, C, 아미노산, 칼륨(K), 코발트(Co), 불소(F), 카로틴, 단백질 등 많은 영양성분을 함유되어 있고, 특히 미역에 함유된 요오드는 갑상선 부종을 방지하고 머리카락이 빠지는 것을 방지하는 것으로 알려져 있다.Seaweed seaweed ( Undaria pinnatifida ) is a brown algae, an alkaline food, also called annual sea cucumber or photosensitive, belonging to the balsam family. According to modern pharmacological studies, many nutrients such as iodine (I), calcium (Ca), vitamin B, B12, B2, C, amino acids, potassium (K), cobalt (Co), fluorine (F), carotene and protein Iodine, especially in seaweed, is known to prevent thyroid edema and to prevent hair from falling out.

콩에는 50여 가지의 여러 품종이 있고, 검정콩 역시 22가지의 종류가 있으나, 본 발명에서는 검정콩(흑대두), 종자가 매우 작은 서목태인 쥐눈이콩(학명: Rhynchosia Nolubilis), 또는/및 서리태(속청)를 이용한다. 콩은 단백질을 비롯하여 칼륨(K), 칼슘(Ca), 철분(Fe) 등의 미네랄류와 비타민 B 등이 풍부하며, 해독 작용이 우수하고, 여성 호르몬과 유사한 천연 성분이 있어 골다공증 방지에 효과가 있다.There are about 50 varieties of soybeans, and there are 22 varieties of black soybeans, but in the present invention, black soybeans (black soybeans), rats with very small seeds (Rhynchosia Nolubilis), or / and Seoryae (Sokcheong) Use Soybeans are rich in protein, minerals such as potassium (K), calcium (Ca) and iron (Fe) and vitamin B. They are excellent in detoxification and contain natural ingredients similar to female hormones, which are effective in preventing osteoporosis. .

또한, 검정콩은 탈모의 원인인 5-알파-환원효소(5-alpha-reductase)의 작용을 저해하고, 활성형 남성호르몬(DHT)의 농도를 낮추는 것이 보고된 바 있다.In addition, black soybeans have been reported to inhibit the action of 5-alpha-reductase, a cause of hair loss, and lower the concentration of active male hormone (DHT).

산초(학명: Zanthoxyloum schinifolium)는 한의학에서는 천초라고도 하는데, 맛이 맵고 성질이 따뜻하여 속을 덥히고 찬 기운과 습을 몰아내어 통증을 가라앉히는 작용을 하며 살충, 해독 작용이 있다. 산초에는 정유가 7% 정도 함유되어 있는데 그중에는 geraniol, limonene, cumic alcohol 등이 함유되어 있다. 산초나무 종자에서 추출한 정유 물질은 국부마취 및 진통작용이 있고, 항균작용에서는 대장균, 적리균, 구균류, 디프테리아균, 황색포도상구균, 피부사상균 등에 억제작용이 있다.Sancho (scientific name: Zanthoxyloum schinifolium ) is also known as cheoncho in oriental medicine. It has a hot taste and warm nature, which warms up the inside, cools down the energy and humidity, and relieves pain. Sancho contains 7% essential oils, including geraniol, limonene, and cumic alcohol. Essential oils extracted from the seeds of the Japanese herb have local anesthesia and analgesic action, and antibacterial action has an inhibitory effect on Escherichia coli, lysiobacteria, cocci, diphtheria bacteria, Staphylococcus aureus, dermatophytes.

이러한 산초는 공업용, 밀원용, 약용으로 쓰이고 민간요법에서는 열매나 나 무껍질, 잎을 말려 가루로 내어 밀가루와 초(酢)로 반죽하여 튼튼한 종이나 헝겊에 펴 바르면 유선염과 종기, 타박상에 좋으며, 치질에는 산초의 어느 부분이든지 달인 물로 씻으면 효과가 있고, 뿌리는 불에 태워 소말(燒末)하여 쓰기도 하며, 달인 물을 마시면 두통과 기침이 멈추고, 두피에 바르면 탈모가 예방된다고 한다.These sanchos are used for industrial, wheat, and medicinal purposes. In folk medicine, the fruit, the bark and the leaves are dried and powdered, kneaded with flour and candles and spread on a sturdy paper or cloth. Hemorrhoids are effective to wash any part of the sancho with decoction water, the root is burned by burning fire (燒 末) to write, drinking decoction to stop headaches and cough, and apply to the scalp to prevent hair loss.

또한, 본 발명에서 상기 '추출물'은 추출액, 정제물, 희석액, 농축액, 및 건조물을 모두 포함한다.In addition, the 'extract' in the present invention includes all of the extract, purified, diluent, concentrate, and dried.

상기와 같은 방법으로 얻어진 추출물은 젖산균 및 효모 중 하나 이상을 접종하여 30~50℃에서 24~72시간을 발효시키는 것이 바람직하다.Extract obtained by the above method is preferably inoculated with at least one of lactic acid bacteria and yeast fermentation for 24 to 72 hours at 30 ~ 50 ℃.

본 발명에서 사용가능한 상기 젖산균은 락토바실루스속 젖산균(Lactobacillus sp.), 스트렙토코쿠스속 젖산균(Streptococcus sp.), 페디오코쿠스속 젖산균(Pediococcus sp.), 류코노스톡속 젖산균(Leuconostoc sp.) 및 비피도박테리움속 젖산균(Bifidobacterium sp.)으로 구성된 군에서 선택되는 하나 이상의 균주일 수 있다. 또한, 상기 효모에는 사카로마이세스 세레비시아에(Saccharomyces sereviciae), 사카로마이세스 루시(Saccharomyces rouxii), 사카로마이세스 오비폴미스(Saccharomyces oviformis), 사카로마이세스 스테이네리(Saccharomyces steineri) 등이 포함된다. 바람직하게는 상기 젖산균으로 락토바실러스 파라카세이(Lactobacillus paracasei)를 사용하는 것이 좋다. The lactic acid bacterium usable in the present invention is Lactobacillus sp., Streptococcus sp., Pediococcus sp., Pediococcus sp., Leukonost sp. And Bifidobacterium sp. Can be one or more strains selected from the group consisting of Bifidobacterium sp. In addition, the yeast includes Saccharomyces sereviciae , Saccharomyces rouxii , Saccharomyces oviformis , Saccharomyces steineri Etc. are included. Preferably, Lactobacillus paracasei may be used as the lactic acid bacterium.

그러나, 상기 균주나 효모의 종류는 본 발명에 따른 조성물이 피부 외용제 등의 형태로 인체에 직접 적용, 도포되므로 인체 안정성과 발효력을 고려하여 선택된 것으로, 인체 안정성 및 발효력이 인정되는 한 당업계에서 사용되는 어떠한 균 주나 효모도 사용될 수 있으며, 본 발명은 상기 젖산균 및 효모의 종류에 한정되지 않는다.However, the type of the strain or yeast is selected in consideration of the human stability and fermentation power, so that the composition according to the present invention is applied directly to the human body in the form of external preparations for skin, etc., used in the art as long as human stability and fermentation power are recognized. Any strain or yeast may be used, the present invention is not limited to the type of lactic acid bacteria and yeast.

또한, 상기 '탈모'는 흉터(반흥성) 탈모증을 제외한 당업계에서 탈모로 분류되는 모든 탈모를 포함하는데, 바람직하게는 원형탈모, 남성형탈모, 범발성탈모, 여성탈모, 소아탈모, 청소년 탈모, 약물에 의한 탈모, 지루성 피부염이나 건선 등 두피 피부질환을 동반하는 지루성 탈모 중 어느 하나 이상의 탈모를 의미한다. In addition, the term 'hair loss' includes all hair loss classified in the art except for hair loss (rebound) alopecia, preferably, alopecia areata, male-type hair loss, general hair loss, female hair loss, pediatric hair loss, adolescent hair loss, It refers to any one or more of hair loss caused by drug hair loss, seborrheic hair loss accompanying scalp skin diseases such as seborrheic dermatitis or psoriasis.

본 발명은 또한 상기 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물을 제공한다.The present invention also provides a hair restorer composition comprising the natural product fermentation extract as an active ingredient.

본 발명의 발모제 조성물은 상기 천연물 발효 추출물을 탈모의 증상 정도나 사용 용도에 따라 인체에의 독성을 미치지 않는 범위 내에서 임의의 양으로 포함될 수 있는데, 구체적으로 조성물 전체 중량을 기준으로 0.001 내지 99.99중량%로 포함될 수 있으며, 바람직하게는 0.1 내지 50중량%로 포함되는 것이 좋다.The hair regrowth composition of the present invention may include the natural fermented extract in any amount within a range that does not have toxicity to the human body depending on the degree of symptoms or use of hair loss, specifically 0.001 to 99.99 weight based on the total weight of the composition It may be included in%, preferably contained in 0.1 to 50% by weight.

본 발명의 조성물은 약제학적 또는 화장학적으로 허용되는 담체를 추가로 함유하며, 크림, 로션, 토닉, 스프레이, 에어로졸, 오일, 용액, 현탁액, 젤, 연고, 에멀젼, 참제, 페이스트 등의 통상적인 제형으로 제조될 수 있다. 본 발명의 조성물은 통상의 기제를 함유하고, 필요에 따라서 일반적으로 약품 또는 화장품 원료로서 사용되는 기타 성분이 적절히 배합될 수 있다.The composition of the present invention further contains a pharmaceutically or cosmetically acceptable carrier and is a conventional formulation of creams, lotions, tonics, sprays, aerosols, oils, solutions, suspensions, gels, ointments, emulsions, sesame seeds, pastes and the like. It can be prepared as. The composition of this invention contains a conventional base, and the other component generally used as a pharmaceutical or cosmetic raw material can be mix | blended suitably as needed.

본 발명의 조성물의 기제는 통상적으로 사용되는 한 어떠한 것도 사용가능하며, 그 예로 정제수, 미네랄워터, 에탄올, 글리세린, 스쿠알렌, 1,3-프로필렌글리 콜, 1,3-부틸렌글리콜, 피마자유, 츠바키유 및 리퀴드 페트롤레이텀(liquid petrolatum)을 포함한다. 본 발명의 조성물에 배합되는 기타 성분의 예는 계면활성제, 유화제, 증점제, 방부제(예를 들어, 파라옥시안식향산메틸), 산화방지제, 향료 등을 포함하며 이에 한정되지는 않는다.The base of the composition of the present invention can be used as long as it is commonly used, such as purified water, mineral water, ethanol, glycerin, squalene, 1,3-propylene glycol, 1,3-butylene glycol, castor oil, Tsubaki oil and liquid petrolatum. Examples of other components to be incorporated into the compositions of the present invention include, but are not limited to, surfactants, emulsifiers, thickeners, preservatives (eg, methyl paraoxybenzoate), antioxidants, fragrances, and the like.

본 발명의 조성물에는 상기 성분 이외에도 모낭에 영영소를 공급하는 역할을 할 수 있는 성분이나 통상적으로 사용되는 모발성장 촉진 보조성분을 포함할 수 있는데, 예를 들면 비타민류, 아미노산류, 동식물유, 염화나트륨 등을 포함하지만 이들로 한정되는 것은 아니다. 이들의 양은 전체 조성물의 0.0001 내지 10중량%, 바람직하게는 0.01 내지 1중량%로 첨가되는 것이 좋다. 이때, 비타민류는 비타민 A, 비타민 B1, 비타민 B2, 나이아신(니코틴산), 비타민 C, 비타민 E, 판토텐산 나트륨, 판토텐산 칼륨, 비오틴 H(비타민 H) 등을 모두 포함하지만 이들로 한정되는 것은 아니며, 아미노산류는 도파를 포함하나 이에 한정되는 것은 아니다. 또한, 동식물유는 마유, 난유, 올리브유, 동백유, 유채기름, 참기름, 배아유 등을 포함하지만 이들로 한정되는 것은 아니다.In addition to the above components, the composition of the present invention may include components that may serve to supply nutrients to hair follicles or hair growth promoting auxiliary components that are commonly used. For example, vitamins, amino acids, animal and vegetable oils, sodium chloride And the like, but are not limited thereto. These amounts are preferably added at 0.0001 to 10% by weight, preferably 0.01 to 1% by weight of the total composition. In this case, the vitamins include all but not limited to vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, biotin H (vitamin H), and the like, amino acids The class includes, but is not limited to, waveguide. In addition, animal and vegetable oils include, but are not limited to, horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, germ oil, and the like.

본 발명의 조성물은 모발 또는 두피에 직접 도포 또는 산포하는 등의 방법에 의해 사용될 수 있다. 본 발명에서 '모발'이란, 머리의 모근 및 모낭, 머리카락 및 속눈썹과 겉눈썹, 수염, 겨드랑이, 음모, 신체 전반에 모근 및 모낭이 있는 모든 부위를 포함한다. 따라서, 본 발명은 헤어토닉, 헤어로션, 헤어크림, 헤어스프레이, 헤어무스, 헤어젤, 헤어컨디셔너, 헤어샴푸, 헤어린스, 헤어팩, 헤어트리트먼트, 눈썹발모제, 속눈썹발모제 또는 속눈썹영양제, 또는 애완동물용 샴푸 및 애완 동물용 린스로 사용될 수 있다.The composition of the present invention can be used by a method such as direct application or scattering on hair or scalp. In the present invention, the term "hair" includes hair follicles and hair follicles of hair, hair and eyelashes, and eyelashes, beards, armpits, pubic hair, and all parts having hair roots and hair follicles throughout the body. Accordingly, the present invention provides hair tonics, hair lotions, hair creams, hair sprays, hair mousses, hair gels, hair conditioners, hair shampoos, hair rinses, hair packs, hair treatments, eyebrow regrowths, eyelash regrowths or eyelash nutrients, or pets. It can be used as a shampoo and pet rinse.

본 발명에 따른 조성물의 용량은 성별, 연령, 탈모증세, 모발상태 등을 고려하여 적절히 결정되어야 한다. 바람직하게는 성인을 기준하여 1일 추출물 3~15 ㏄으로 1~5회 적용될 수 있다.The dose of the composition according to the present invention should be appropriately determined in consideration of sex, age, alopecia, hair condition and the like. Preferably it can be applied 1 to 5 times 3 ~ 15 추출물 1 day extract based on the adult.

본 발명의 발모제 조성물을 가장 난치성이라고 하는 남성형 탈모 환자에게 도포하는 경우, 1~8주가 경과하면 머리털이 굵어지면서 탈모가 현저히 감소하며, 8~12주가 경과하면 솜털이 나오기 시작하며, 도포 후 12개월 후부터는 거의 정상인의 수준으로 돌아왔다.When the hair regrowth composition of the present invention is applied to a male hair loss patient, which is said to be the most refractory, hair loss becomes significantly reduced after 1 to 8 weeks of thickening, and after 8 to 12 weeks, hairiness starts to appear, and 12 months after application Since then, it has returned to the normal level.

또한, 비듬균 지루성 피부염에 대해서도 살균효과가 탁월하여, 지루성 탈모증세가 있는 환자에게 도포한 결과, 3개월 후에는 두피개선효과와 동시에 탈모도 완치됨을 확인할 수 있었다. 따라서, 본 발명의 조성물은 탈모방지제, 발모촉진제, 육모제, 두피세정제, 비듬치료제 등에 사용 가능하다.In addition, the bactericidal effect against dandruff bacteria seborrheic dermatitis was excellent, and when applied to a patient with seborrheic alopecia, it was confirmed that after 3 months, the hair loss improvement and complete hair loss. Therefore, the composition of the present invention can be used for hair loss preventing agent, hair growth promoting agent, hair growth agent, scalp cleaner, dandruff treatment agent and the like.

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

실시예 1. 천연물 발효 추출물 제조Example 1. Preparation of natural product fermented extract

시중에서 구입한 솔잎, 미역, 콩, 산초를 잘 건조시킨 후 각각을 분말화 하여 1 : 1 : 7 : 1의 중량비로 혼합한 다음, 혼합 분말에서 500 g을 취하여 여기에 물 6 ℓ을 넣은 후 95~100℃에서 24시간 동안 추출하였다. After drying commercially available pine needles, seaweed, soybeans, and peppers, each powdered and mixed in a weight ratio of 1: 1: 7: 1, 500 g of the mixed powder was added, and 6 L of water was added thereto. Extraction was performed at 95-100 ° C. for 24 hours.

상기 추출액은 여과 후 멸균하고, 상기 멸균된 추출액에 젖산균(Lactobacillus paracasei KW3110)을 추출액 100 ㎎당 균주 10 ㎎의 농도로 첨가하여 35~40℃를 유지하면서 72시간(3일) 동안 발효시켜 천연물 발효 추출물을 제조하였다. The extract was sterilized after filtration, and the sterilized extract was added with lactic acid bacteria ( Lactobacillus paracasei KW3110) at a concentration of 10 mg of strain per 100 mg of extract, followed by fermentation for 72 hours (3 days) while maintaining 35 to 40 ° C. An extract was prepared.

실험예 1.Experimental Example 1

탈모증세가 심한 사람 25명을 대상으로 1일 1회 샴푸 후 타월드라이하고, 상기 실시예 1에서 제조한 천연물 발효 추출물을 탈모가 진행된 두피에 9~15 ㏄를 골고루 바르고 마사지 하는 방법으로 최초 3개월에서 1년 이상을 사용한 후 그 결과를 관찰하였다.To 25 people with severe hair loss symptoms shampoo once a day and then towel-drying, the natural product fermented extract prepared in Example 1 was applied evenly to the scalp with a hair loss to 9 ~ 15 골 evenly massage method in the first three months After more than 1 year of use, the results were observed.

도 1 내지 도 6에서 나타난 바와 같이, 모든 실험대상자에서 탈모가 현저히 줄어들면서 발모효과가 확인되었으며, 피부자극이나 부작용은 실험기간 동안 전혀 없었다.As shown in Figure 1 to 6, hair loss was confirmed in all subjects significantly reduced hair loss, there was no skin irritation or side effects during the experiment.

이상, 본 발명의 내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다고 할 것이다. As described above, specific portions of the contents of the present invention have been described in detail, and for those skilled in the art, these specific techniques are merely preferred embodiments, and the scope of the present invention is not limited thereto. Will be obvious. Thus, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

도 1은 남성형 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 사용하기 전과 사용 15개월 후의 상태를 보여주는 사진이다.1 is a photograph showing the state before and 15 months after using the natural product fermentation extract of the present invention to test subjects with androgenetic alopecia.

도 2는 지루성 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 사용하기 전과 사용 3개월 후의 상태를 보여주는 사진이다. Figure 2 is a photograph showing the state before and after 3 months of use of the natural product fermentation extract of the present invention to the test subject with seborrheic alopecia.

도 3은 여성형 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 사용하기 전과 사용 10개월 후의 상태를 보여주는 사진이다. Figure 3 is a photograph showing the state before and 10 months after using the natural product fermentation extract of the present invention to test subjects with gynecomastia.

도 4는 원형 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 사용하기 전과 사용 10개월 후의 상태를 보여주는 사진이다. Figure 4 is a photograph showing the state before and 10 months after using the natural product fermentation extract of the present invention to test subjects with alopecia areata.

도 5는 전신 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 사용하기 전과 사용 12개월 후의 상태를 보여주는 사진이다. Figure 5 is a photograph showing the state before and 12 months after using the natural product fermentation extract of the present invention to test subjects with systemic hair loss.

도 6은 전두부 탈모 증세를 가진 실험 대상자에게 본 발명의 천연물 발효 추출물을 (A) 사용하기 전과 (B) 사용 5, 6 및 12개월 후의 상태를 보여주는 사진이다. Figure 6 is a photograph showing the condition before and after the use of the natural product fermented extract of the present invention (A) and 5, 6 and 12 months after the use of (B) to test subjects with hair loss.

Claims (5)

탈모방지, 발모촉진 및 육모 효과를 가지는 천연물 발효 추출물.Natural product fermentation extract having hair loss prevention, hair growth promotion and hair growth effect. 제 1항에 있어서,The method of claim 1, 상기 천연물 발효 추출물은 솔잎, 미역, 콩 및 산초에서 선택되는 1종 이상을 혼합하여 추출한 후, 추출액에 젖산균 및 효모 중 하나 이상을 접종하여 30~50℃에서 24~72시간 동안 발효시켜 제조되는 것을 특징으로 하는 천연물 발효 추출물.The natural product fermentation extract is prepared by mixing one or more selected from pine needles, seaweed, soybeans and acid, and then inoculating one or more of lactic acid bacteria and yeast in the extract is fermented for 24 to 72 hours at 30 ~ 50 ℃ Characterized in natural product fermented extract. 제 2항에 있어서,3. The method of claim 2, 상기 젖산균은 락토바실루스속 젖산균(Lactobacillus sp.), 스트렙토코쿠스속 젖산균(Streptococcus sp.), 페디오코쿠스속 젖산균(Pediococcus sp.), 류코노스톡속 젖산균(Leuconostoc sp.) 및 비피도박테리움속 젖산균(Bifidobacterium sp.)으로 구성된 군에서 선택되는 하나 이상의 균주인 것을 특징으로 하는 천연물 발효 추출물. The lactobacillus is Lactobacillus sp., Lactobacillus sp., Streptococcus sp., Pediococcus sp., Pediococcus sp., Leuconostoc sp. Natural product fermentation extract, characterized in that at least one strain selected from the group consisting of Bifidobacterium sp. 제 1항 내지 제 3항 중 어느 한 항의 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물. Hair repellent composition comprising the natural product fermented extract of any one of claims 1 to 3. 제 4항에 있어서,The method of claim 4, wherein 상기 조성물은 탈모방지제, 발모촉진제, 육모제, 두피세정제 또는 비듬치료제로 제형화 되는 것을 특징으로 하는 발모제 조성물.The composition is a hair loss composition, characterized in that is formulated as a hair loss preventing agent, hair growth promoting agent, hair growth agent, scalp cleaner or dandruff treatment agent.
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