JPH11209246A - Hair-tonic and hair-growing agent mixed with vegetable extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hair-tonic and hair-growing agent having excellent trichogenous and hair-growing effect, imparting the hair luster, springiness and smoothness, improving the combing smoothness, safe to human and animal and applicable to general foods and drinks. SOLUTION: This hair-growing agent contains an extract of Salvia splendens and/or BOTANPI (root of Paeonia moutan) in combination with extract of one or more kinds of plants selected from among Plectranthus rugosus, Scutellaria baicalensis, Hypericum erectum, Magnolia obovata, comfrey, cherry, Perilla frutescens crispa, Paeonia albiflora, stevia, Pinellia ternata, Pachyma hoelen, Ficus religiosa, Salvia splendis and Paeonia moutan.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a plant extract of at least one of salvia and buttonpig, further comprising:
1 selected from Sakura, Perilla, Peony, Stevia, Hange, Bakuryo, Bodaiju, Salvia, Bonapi
The present invention relates to a novel and safe hair-growth / hair-growth agent in which the regeneration of hair is significantly recognized when used in combination with plant extracts of more than one species.

[0002] The field of application can be used in all kinds of external preparations (including preparations for animals). Specifically, capsules, powders, granules, solids, liquids,
Gel or foamy 1) pharmaceuticals, 2) quasi-drugs, 3)
Topical or systemic skin cosmetics, 4) Medicinal and / or cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair dressings, hair tonics) , Hair restoration, hair restoration, etc.)
Is raised.

[0003]

2. Description of the Related Art Hair greatly affects the appearance and occupies a very important position in beauty. Alopecia is still a matter of deep concern, with no precise cure. There are two types of alopecia, congenital and acquired. There are many studies on the causes and mechanisms of alopecia, but there are many unclear points. Currently, many are on the market.

At present, the causes of hair loss are considered to be due to abnormalities in the endocrine system, abnormalities in the hair cycle, autonomic nervous disorders, nutritional disorders, and other causes caused by hereditary or aging. Further, as a conventional hair growth and hair growth component, for example, linoleic acid monoglyceride (JP-A-63-20163)
114), estrogen (JP-A-60-38313)
), Vitamins such as vitamin E, B2, B6, biotin, pantothenic acid, and other amino acids (peptide substances: Japanese Patent Application Laid-Open No. 61-7209).
No.) and existing peripheral blood circulation promoters (vitamin E and its derivatives, assembly extract, garlic extract, ginseng extract, aloe extract, cepharanthin, carpronium chloride, minoxidil, etc.), local stimulants (capsicum tincture, nonylate vanillamide, showa) Tincture, peppermint oil,
An inflammatory agent (glycyrrhizic acid, licorice extract, diphenhydramine hydrochloride, etc.) is known.

[0005] Then, the above-mentioned hair growth and hair growth components are used alone or in combination with a plurality of hair growth and hair growth effects, and are used for hair growth and hair growth.
Many are aimed at comprehensive hair-growth and hair-growth effects such as promoting hair growth, preventing dandruff, Kayumi, inflammation, and preventing thinning and hair loss.

[0006]

SUMMARY OF THE INVENTION As described above, hair growth and scalp used for the purpose of growing or maintaining the hair of the scalp and skin.
Various components and techniques have been proposed for hair growth agents, and they are actually used at present. However, these hair restorers / hair restorers are not always effective enough and are not satisfactory in terms of safety such as causing skin irritation.

Therefore, attention has been paid to the effect of converting the rest period of the hair cycle into the growth period.
Attempts have been made to use the active ingredient as a hair tonic and hair restorer. In addition, the reason why the conversion effect from resting to anagen is used as hair growth and hair growth is that it is considered that in people with alopecia, the proportion of quiescent hair in the growth process of hair occupies the scalp / hair. Therefore, focusing on the hair cycle of hair, we have been studying and pursuing a hair nourishing and hair restoration agent that is effective in stimulating the quiescent roots and speeding up the transition to the anagen phase, and have been conducting intensive research. .

[0008]

In view of these circumstances, the present inventors have developed a useful plant having a hair-growing / hair-growing effect as a theme of development, and as a result, have been able to extract at least one plant selected from the group consisting of salvia and buttonpipi. Regeneration of hair by using in combination with one or more plant extracts selected from the group consisting of Emisoso, Ogon, Hypericum perforatum, Kouboku, Comfrey, Sakura, Perilla, Peonies, Stevia, Hange, Bakuryo, Bodaiju, Salvia, Pontopi Is significantly recognized,
It was confirmed to have hair-growth and hair-growth effects. Also, by providing a highly safe hair restoration and hair growth agent that gives hair gloss, tension and smoothness, and improves comb passage,
The present invention has been completed.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION "Salvia" used in the present invention is Labiatae or Salvia.
Flower, leaf, whole plant of Salvia officinalis L. (alias: sage).

"Peony: Peony" refers to the Paeaceae family (Pae).
oniaceae), a plant belonging to the genus Paeonia, the button "Paeo
nia moutan Sims (= Paeonia suffruticosa Andrews) "
Root bark.

[0011] The term "Emisoso: prolonged life grass" refers to a plant of the labaceae (Labiatae) and the genus Rabdosia (Rabdosia japonicus (Burm.f.) Hara (= Isodon j).
aponicus Hara) "or Isodon tri
Above ground or whole grass of chocarpus Kubo).

"Ogon: Yellow Gon" is a Labiatae (Labi
atae), a root of the plant Scutellaria baicalensis Geoegi of the genus Scutellaria excluding the pericytes.

[0013] "Hypericum perforatum" includes plants of the family Hypericum (Guttiferae), Hypericum spp. (Hypericum), Hypericum erectum Thunb., Hypericum perforatum L. (Hypericum perforatum L.), and L. perforum germ (Hypericum perforum erupium L.).
iom DC) whole grass.

"Kouboku: magnolia" means magnoliaceae (Ma
gnolaceac), Magnolia plant spinach (Magnolia obovata Thunberg), Colorado (Magnolia o)
bark of stems and branches of fficinalis Rehder et Wilsons), Magnolia sprengeri Pamp. or other closely related plants.

"Comfrey" refers to the family Boragi (Boragi)
naceae), leaves of a plant comfrey (Symphytum officinale Linne) of the genus Symphytum.

"Sakura: cherry blossoms" refers to the rose family (Roacea
e), genus Prunus, subgenus sakura (Subgen. Cerasu)
s) Plants Oshima cherry (Prunus speciosa), Yamazakura (Prunus jamasakura), Oyama cherry (Prunus)
sargentii), edohigan (Prunus spachiana), mamezakura (Prunus incisa), Miyazaki cherry (Prunus maxi)
mowiczii), Yoshino cherry tree (Prunus yedoensis), Takanezakura (Prunus nipponica), Kasumizakura (Prunus)
leveilleana), Chow Ziza (Prunus apetala),
Kohigan (Prunus subhirtella), Satzakura (Prunus)
lannesiana), leaves of cherry such as Prunus kanzakura.

"Perilla: Shiso" refers to the Labiatae family (Labiata).
e) Perilla plant (Perilla frutesce)
ns Britton var. acuta Kudo) or other closely related plants.

"Peony: peony" refers to the button family (Pa
eoniaceae), a plant of the genus Paeonia, a peony "Paeonia lactiflora Pallas (= Paeonia albiflora P
allas) or other related plant roots.

"Stevia" refers to asteraceae (Composita
e) Stevia plant of the genus Stevia (Stevia re)
baudiana Bertoni) leaves and branches. In addition, what contains a steviol glycoside (stevioside) is preferable.

"Hange: midsummer" refers to the taro family (Arac
eae), the plant of the genus Pinellia (Pinellia)
Inellia ternata Breitenbach) root mass without cork layer.

[0021] "Bukuryo: Bukuryo" is a sclerotium of a plant of the genus Polyporaceae (Polyporaceae) and Poria cocos Wolf (Poria cocos).

"Bodaiju: Bodaiki" means Tiliaceae, Tilia platyphyllos Scop., Tilia platyphyllos Scop.
ia cordata Mill.), Tilia europaea
L.) or other closely related flowers, fruits, bark.

[0023]

BEST MODE FOR CARRYING OUT THE INVENTION The extracts of salvia, bogpi, fragrant magnolia, ogon, hypericum perforatum, kouboku, comfrey, cherry, perilla, peonies, stevia, hange, bakuryou, and bodaiju used in the present invention are the respective plant bodies. Various parts (whole plant, above-ground part, flower, fruit, leaf,
Branch, bark, root bark, rhizome, root, sclerotia, etc.) or crushed and squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

In addition, salvia, buttonpi, enmeiso,
Various plant extracts such as Ogon, Hypericum perforatum, Koboku, Comfrey, Sakura, Perilla, Peony, Stevia, Hange, Bakuryo, Bodaiju can be dried, concentrated or diluted depending on the type and form of the applied hair tonic / hair restorer. And adjust it.

The production method is not particularly limited, but may be usually within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or use of an ion-exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added to the extent that the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The extract of salvia and buttonpi of the present invention comprises:
It can be blended into a hair restorer / hair restorer, but the amount is not specified, but the type, quality,
Depending on the expected degree of action,
% By weight or more (hereinafter, expressed as% by weight)
99% is good. If the amount is less than 1%, the effect cannot be expected sufficiently.

Similarly, the various plant extracts of the present invention, such as E. ginseng, Ogon, Hypericum perforatum, Koboku, Comfrey, Sakura, Perilla, Peony, Stevia, Hange, Bukuryo and Bodaiju, can also be incorporated into a hair-growing / hair-growing agent. The amount is not particularly limited, but slightly varies depending on the type, quality, and expected degree of action of the hair restorer / hair restorer, but is usually 1% by weight or more (hereinafter, represented by weight%). Preferably, 20 to 50% is good.
If the amount is less than 1%, the effect cannot be expected sufficiently.

The hair-growing / hair-growing agent of the present invention may be used in addition to the above-mentioned essential components, if necessary, in the preparation of pharmaceuticals, quasi-drugs, cosmetics, etc., as long as the effects of the present invention are not impaired. It can be produced by arbitrarily selecting and using the components and additives used.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane, and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salts, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

The specific plant (crude) used as a raw material includes:
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsujirafuji (Kibo), Aono Ryukyuran, Fukurin Ryuetsuran, Acacia, Akasugi Fruit, Akavine, Akamegashiwa (Red Bud), Akane (Akane Grassroot), Akayajiou Jio (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Asuka), Azuki (Red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit , Avocado, flax, amateur (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Usenitachioi, Echinacea purpurea (summer hay), Udo or Shishiudo (Qang, Independent, Tang Independent), Ume (Umei) or its flesh, Vladigashi, Oolong tea, Uwaurushi, Unshurikan (Chen skin), Estragon, Ezocogi (Yezo five) , Ezoki strawberry, Echinashi (Echinacea purpurea), Enoki, Ebisugusa (Keiko), Elderberry fruit, Elemi, Enju (Gossip flower, Sophora edulis), Ogi / Kibaanagi (Associated rice), Ouren (Yoren), Okarasuuri (Karonin) ), Ootsuji Lafzi (self-defense), Psyllium (vegetative child, vegetative grass), Toucan hazel (Haruko), Obanana okera okera
(White ajutsu), fruit of the sedge beetle, hawthorn hawthorn, hawthorn (Yamatoko), snowy squirrel, snowy squirrel, barley (barley), ogurma (turning over), okra fruit, panax ginseng and tochibanzin (carrot), swordfish (continuous) Ears), Onigurumi, Oninoyagara (Tianma), Onyuri Sasasayuri Hakatayuri (Yuri), Ononis, Halibut (Hashiha Yu), Ominaeshi (Loose), Dutch Strawberry, Dutch Karashi (Cresson), Dutch Jelly, Dutch Mitsuba, Olive, oregano, orange fruit or pericarp, calyxio (ripe yellow), cacao seeds, oysters or leaves (persimmon), kagi kazura (chotou hook), cassia, kasinaki fruit (kotsumi), gajutsu (shajiatsu), kashiwa (Kazuki, Sakura), Cascarilla, Kanixa (Kinosato), Valeriana (Kikusone), Birch or Weeping birch (White birch), Pumpkin, Ka Poknut tree seeds, Kahokoku-sansho (shopper), Gama (Kamaoh), Chamomile ・
Roman chamomile, Kamiyatsude (weed plant), crow squirrel (flower meadow), oak wheat, guarana seed, karaya, karin (mouse gourd), garcinia, kawayanagi, kawatake mushroom, kawamoyomogi (inchinko), kansui (sweet), licorice (licorice), Kantala Asa, Candelilla, Canto, Canna, Raspberry, Kiwi Fruit, Kikarasuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum), Kisage (Azusa), Gigi
(Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachi mint, Kina, Kinoki (Shincona, Akakinoki), Yellowfin (Huangbashi), Gymnema sylvesta, Cabbage, Cabbage immature, Cucumber, Kiraja saponaria, Kiraya, Kumquat fruit , Betel, golden hibiscus (Sesame crane), guava fruit, guayule, Quercus infectria (gallicate), kukui nuts, wolfberry (Gugi, gugiko, gugi leaf, skeletal bark), Kusugi Kazura (Tenmen winter), Kudzu
(Kakkon), camphor tree, gooseberry fruit, gardenia (garden garden), kunugi (bokusou), kumazasa, black pine tree (mawhisher), clara (bitan), cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, Buckthorn, black crab, rescue, clove
(Crotch, Choka), Kaigai (Echigo, Ikugoho), Keito (Rooster, Chicory), Gekkeiju (laurel), Kenashisarutoribara (Tokubukuryo, mountain return), Gentiana, Gennoshoko (Oldbrow grass), Koshinbara (Monthly) Flower), crow mint, kouzo fruit, kocha (tea), kohone (river bone), kouhon (straw and kara straw), kouriang, cilantro fruit,
Cowberry (Koshibachi), Coconut fruit, Goshuyu (Gusyuyu), Goshoyutigo (covered bunko), Pepper (pepper), Copaiba balsam, Coffee beans, Kobushi magnolia (Spicy), Burdock (burdock, burdock), Kobotur, sesame (Sesame), sesame seeds (Gensan), garnish (Gomiko), Sanekazura, Binankazura, Matsubusa, wheat (wheat), rice, rice bran (red bran, white bran)
Rice oil, cola acuminata seeds, cola vera seeds,
Fenugreek fruit, colombo, kondurango, konjac, sisal, sisal asa, saximabotdul,
Cherries, pomegranates, sasa, sasanqua, sagiomodaka
(Sawaka), sweet potato, sugar cane, sugar beet, sapling jujube (acid jujube), saffron (safflower, west safflower), pomelo fruit, sabonso, salmonberry fruit, sarashinasho (masuma), sawagikyo (yamakonasai), sawagurumi ( Wild walnut), Panax ginseng (37 ginseng), Sanshuyu
(Susyuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyanoki fruit, Shiitake (Shiitake), Shion
(Shien), red squirrel, red beetle (mikomiko), rosewood, linden, Chinese forsythia (forsythia), sycamore (chrysanthemum flower), sycamore, potato, shajin (shasan), janohige
(Bakumon Winter), Juzudama, Palm Fruit, Ginger (Ginger),
Shobu (irises, iris roots), shrimp fruits, birch seeds, white butterfly butterflies, white bananas, white banana flowers, white minant (Nantami), cinchona cassula bra, cinnamon, watermelon (watermelon), honeysuckle (gold and silver flowers,
Shinobi winter), sorrel (acid model), swimberry fruit, strawberry fruit, horsetail (thorn), plum fruit, Scots pine cone, pine larch, Scots vine, Scots walnut, Scots hawthorn, Scots dandelion, Scots cypress (Maloney), Pear fruit, snowy pear, European elderberry, elder tree (juniper and juniper), yarrow (milfoil), balsam pear, balsam pear, mistletoe, smelt, and swordfish Root), mallow, hirohasenega, senega, seri, celery, senkyu (river cucumber), sendan, senburi (drug), senna fruit or leaf, senninsou (large tate), souka (grass), buckwheat seeds, soybean imo, rhubarb (Big ), Radish, soy, orange (orange peel, Fructus Aurantii Immaturus), Euphorbia pekinensis (Dai戟), Takawarabi
(Gull), dark sweet cherry fruit, hollyhock, hollyhock (thyme, Hyakuka), hollyhock (tachibana skin), hollyhock willow, tamarind seeds, onion, tamashiba (spicy), arachis or its root bark, tanjin (dansan), dandelion (Gakukohide) or white dandelion and moko dandelion, dammar, cherry fruit, chigaya or its root (chinese), chikusetsu carrot (bamboo ginseng), chicory, ginseng
(Gomiko), Korean Radish (Ohio), Korean Elm
(Wuyi), Ginseng (Ginseng), Artemisia
(Aiba), Choreimaitake (Irei), Tsukimiso, Tsukuritake (mushroom), Camellia, Camellia, Clover
(Lacquer mother grass), asiatica (duckling primrose), vine adzuki (red azuki bean), tsuldokudami (what a crow), tsuruna (apricot apricot), truss ginseng (four-leaf ginseng), tsuwabuki, daico, teuchigurumi, duberry fruit, daidaiyaku (crow medicine), Pepper (winter melon), pepper (bancho), touki (toki), calendula (marigold), corn or corn hair (nanban hair),
Horned moth (woman Sadako), tourindo (ryu-bili), dokudami (jujutsu), radish (tomato), toshishi, medadaoshi, and shinashikazura, eucommia (tonaka, tonakaha), tomato, tragacanth, triacanthos seed, tormentilla, dronoki, Troroaoi, Niseria berry fruit, Yam yam (Yakuyaku), Nagikadida (Butcher Bloom), Naginata Koju, Nazuna, Rape, Natsumikan, Jujube (daijutsu), Naniwaiba (Kinzakurako), Nameko, Narco lily (Yellow), Peanut (Peanut), Nanten (Minami Tenmi), Nigaki (Maki), Shrimp Mug (Agai), Nikuzuku (Nutmeg),
Kay Nikkei (Kihi bark), Keishi (Keishi), Chinese chive (Nirako),
Fruits, flowers or foliage of elderberry (bone-attached tree), garlic (garlic), nurde (fivefold), green onion, thistle (daiji), wild rose (fruit), saw millet, nodake (maehu), nobara, peach, palm, pineapple Fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone Crushing), Hakusen (Rinosaur), Huckleberry Fruit, Hakbe (Regular), Hazel (Haruko), Hashiridoro (Rot Root), Basil, Lotus (Lotus Meat) , Rensui), parsley (Netherlands jelly), naked mussels, batata, hachiku madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuninin), hanasuge (chimochimo), banana, hana mint, vanilla bins, papaya , Hawk grass (rat malt grass), hub grass, paprika, hamagou / mitsubahamagou (vine thorn), hamasuge (kosuke), hamabishi (situriko), hamanas (maikai flower) ,
Hamabofu (beach storm), Hamamelis, Rose (rose), Parietaria, Harunire (Yellow, Yuhakuh, Yuba), Breadfruit,
Hiogi (sun dried), lizard carrot (party party), pecan nuts, gangamana (stone and vines), Hishi (Rishimi),
Statio, Beet, Hitotsuba (stone reed), Hinata Kozuchi
(Cow knee), hinoki, hiba, castor, sunflower, pepper,
Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta fruit, Juniper, Bjackyu,
Butterfly fruit, below-flowered oyster, broad-leaved oak grass (Hakuto-oka), loquat (loquat, loquat leaf), betel wax (large clothing skin, betel locust), spruce buds (southern rattan), butterflies, red-crowned dandelion (winter flower, winter leaf), fujibakama (lane grass) ), Fuji bean (flat beans), grape fruit or pericarp, seeds and leaves, beech, Fuyumushinatsukutaketake (Cordyceps sinensis), Brazilian liquorice, black currant fruit, blackberry, plum fruit, furcellaria,
Blueberry (Prunus avium), prunes, blond psyllium, bundo (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruits, perbianberg, boysenberry fruits, boufu (windproof), spinach, physalis (Torone) , Bokeh (Gourd), Hosoba-naokera (Sojutsu), Hosobabarengiku, Hops, Jojoba, Whiteberry Fruit, Hongshimeji, Meisurutennanshaw
(Tiannan star), Ephedra (mao), Macadamia nut, Macri
(Sea-grass), maguwa (mulberry white skin, mulberry leaf), red snapper (kiten tate),
Matsukasa, pine needles, mayola (Hanaminka), malvanozadin (bitter), mulberry fruit, quince, mango, mangosteen, manshugulumi, mandarin fruit, mannentake (reishi), citrus plant fruit (kikomi), mishimasaiko (saiko), Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Myoga,
Miracle fruit fruits, Myrrh, Myrobaran, Mukuge
(Mt. Geun), Mukunoki, Mukuroji, Murasaki (purple root), Murasaki maize, Mehajiki (mother grass), Mebogi, Melaleuca, Melissa, Melilot, Melon fruit, Moko-yomogi, Moso bamboo, Mokko (tree incense), Momijibadaio, peach leaf (Peach leaves), fruits, seeds (peach kernels), bean sprouts, morello cherry fruits, moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yashabushi (arrow wheel), yachinagi, yatsude
(Octagonal gold plate), mistletoe (willow parasite), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yumemei), yamayomogi, eucalyptus, yukinoshita (tiger ear) (Grass), Yucca flevifolia, Yuzu fruit, lily, yorigusa, (European strawberry), mugwort (Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaf and fruit, lavender, longan
(Longan meat), ryocha (green tea), apple fruit, gentian,
Lubas suavisimus (sweeten), lettuce, red currant fruit, lemon fruit, lemongrass, forsythia, forsythia, coconut palm, loganberry fruit, log wood, rosemary (mannen wax), rose hip
(Nobara), Wasabi and Waremokou (Jiyu).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown algae: Kombu alga; , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohigemawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Cyanobacteria (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomid spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

Wheel algae (Characta spp., Rhododendron spp.,
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include chicken crown extract, cow and human placenta extract, pig and cow stomach and duodenum or intestinal extract or its decomposition products, and pig and cow spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposition products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation product of skim milk powder, trehalose or a derivative thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placental extract, silk peptide, plant extract (mulberry, corn, waremoko,
Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, artea, keihi, mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, hemp yellow, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genenoshoko, Kakkon, Licorice, Gopiko, Aloe, Shouma, Safflower, Green Tea, Tea, Asenyaku).

(20) Melanin pigment reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of Turnover / Cell Activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, age extract extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, lactic acid Sodium, Mini Sasanishiki extract, etc.

(29) Agents for hair Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrone, etc.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Topical stimulants Pepper tincture, nonylate vanillamide, cantharist tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(34) Antiseborrheic agents Pyridoxine and its derivatives, sulfur, vitamin B _{6 and the} like.

(35) Keratolytic agents Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(39) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(40) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(41) Nutrition enhancer Shell calcined calcium, cyanocolabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(42) Dairy products Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the hair-growing / hair-growing agent of the present invention is arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, It can be used by blending it in sheet-like pharmaceuticals, quasi-drugs, and cosmetics for skin and hair.

Specifically, for example, a pharmaceutical preparation for external use, cosmetics such as cream, lotion, oil, shampoo,
Hair cosmetics such as rinses, hair treatments, hair creams, pomades, hair sprays, hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair restoration, etc.
Use for general foods and drinks is also possible.

The method of adding the various plant extracts of the present invention to a hair growth and hair growth agent may be added in advance or during the production, and may be appropriately selected in consideration of workability. Good.

[0086]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Preparation Example 1) 100 g of each plant of Salvia, botanic pipiens, Japanese calyx, Ogon, Hypericum perforatum, Kouboku, Comfrey, Sakura, Perilla, Peonies, Stevia, Hange, Bukuryo and Bodaiju, purified water (about 80 ° C.) For about 5 hours, followed by filtration to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 3.0% by weight).

(Production Example 2) 100 g of each plant of salvia, buttonpig, fragrant magnolia, Japanese gourd, Hypericum perforatum, Kouboku, Comfrey, Sakura, Perilla, Peony, Stevia, Hange, Bukuryo and Bodaiju were immersed in a 50% ethanol solution. After extraction at room temperature for 5 days and nights, filtration was performed to extract the extract (dry solid content: about 0.1 to 3.0% by weight) to about 1.
Get 0kg.

(Production Example 3) 100 g of each plant of salvia, botanic pipiens, fragrant magnolia, Japanese gourd, Hypericum perforatum, Kouboku, Comfrey, Sakura, Perilla, Peony, Stevia, Hange, Bukuryo and Bodaiju are each in 70% ethanol solution or 30%. 1,3-butylene glycol solution or 60% propylene glycol solution, or purified water (about 30
C.), extracted at room temperature for 5 days and nights, and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 3.0% by weight).

(Test 1) C3H mouse hair growth promotion test Approximately 8 cm ² of the back of the animal was shaved with an electric clipper and an electric shaver. Next, apply the sample once a day to the hair-removed back about 0.2m
l was applied 5 days a week for 20 days. On the 12th and 20th days after application, the area ratio (%) at which hair regeneration was observed relative to the area from which the hair had been removed was measured with an image analyzer, and compared with the control group. The results are shown in FIGS. "Ogawa et al.'S test method (Flexibility Journal, Vol. 17, No. 5, P. 20-29 (198
9)

(Test Method) a. Samples The various plant extracts obtained in Production Example 2 of the present invention were used as undiluted solutions, and the plants were mixed in equal amounts. As a control, only a 50% aqueous ethanol solution of the base was used. As a positive control, minoxidil was added to a 50% ethanol aqueous solution in 0.5%.
% (w / v) dissolved and used plant extracts (stock solution) of salvia, buttonpig, emmeso, ogon, hypericum, kouboku, comfrey, cherry, perilla, peonies, stevia, hange, bakuryo, bodaiju . b. Experimental animals 8-week-old male C3H mice were used. These animals were bred in an environment of room temperature 22 ± 2 ° C., humidity 50 ± 15%, all-fresh ventilation 15 times / hour, and lighting 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

(Test Results) As shown in FIGS. 1 to 3, at least one plant extract of salvia and buttonpi of the present invention was further added to emisoso, ogon, hypericum, kouboku,
Comfrey, cherry, perilla, peonies, stevia, hange, bukuro, bodaiju, salvia, a combination of at least one plant extract selected from botanpi, hair regeneration is significantly more significant, and minoxidil or Compared with various plant extracts alone, almost equal or higher hair regeneration was observed.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were added to purified water so that the dry solid concentration was about 0.5 W / V%. Japanese white rabbit (female, 3 per group, weight 2.3kg)
Before and after). The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test Similarly, various plant extracts obtained in Production Examples 1 to 3 were purified so that the dry solids concentration was about 0.5 W / V%. Hartley guinea pigs prepared with water and shaved on the flank (female,
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 ml / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, powders obtained by concentrating and drying the various plant extracts obtained in Production Examples 1 to 3 (dry solid content: about 1.0 W / V
%) Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old) in a 2,000 mg / kg dose fasted for 4 hours before the test, and the appearance and extent of toxic symptoms were observed over time. did. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50 is
It was determined to be 2,000 mg / kg or more.

(Formulation example) Production of hair growth and hair growth agent According to the above evaluation results, the formulation examples are shown below. Each formulation example may be one manufactured by a conventional method in the manufacture of each product. showed that. Further, the present invention is not limited to these.

(Formulation Example 1) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Salvia 50% ethanol extract B: Buttonpi 50% ethanol Extract C: 50% ethanol extract of E. ginseng D: 50% ethanol extract of Euglena E: 50% ethanol extract of Hypericum F: Kokuboku 50% ethanol extract G: Comfrey 50% ethanol extract H: Sakura 50% ethanol extract Liquid I: Perilla 50% ethanol extract J: Peony 50% ethanol extract K: Stevia 50% ethanol extract L: Hange 50% ethanol extract M: Bucurio 50% ethanol extract N: Bodaiju 50% ethanol extract * Extract of any one of A and B 20.0 * Extract of any one of C to N 10.0 5. Preservatives qs 6. Purified water 100 That the residual

(Formulation Example 2) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Salvia 50% ethanol extract 10.0 7. Comfrey 50% ethanol extract 10.0 8. Sakura 50% ethanol extract 10.0 9. Appropriate amount of fragrance and preservatives 10. Purified water 100 residue

(Formulation Example 3) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Buttonpip 50% 1,3-butylene glycol extract 10.0 6. Stevia extract 5.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 7. Peony 50% 1,3-butylene glycol extract 5.0 8. pH adjuster qs 9. Preservative qs 10. purification Water 100 and the rest

(Formulation Example 4) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Salvia 30% ethanol extract 15.0 6. Bulk Phenol 50% Phosphoric Acid Liquid Extract 7.0 7. Preservatives appropriate amount 8. Purified water 100 residue

(Formulation Example 5) Lotion% by weight 1. Sorvitol 2.0 2.1.3-butylene glycol 2.0 3. Polyethylene glycol 1000 1.0 4. Polyoxyethylene oleyl ether (25E.O.) 2.0 5. Ethanol 10.0 6. Salvia 50 % Ethanol extract 5.0 7. Ougon 50% ethanol extract 5.0 8. Sakura 70% butylen glycol extract 5.0 9. pH adjuster qs 10. Preservative qs 11. Purified water 100

(Test 5) Use Effect Test The effect of the hair growth and growth agent of the present invention actually used was examined. The test used was a panel of 10 people (25-50 years old) complaining of alopecia and alopecia. The hair of Formulation Example 1 was used twice daily, morning and night (after washing the hair at night), twice in total. The usage test was performed by applying an appropriate amount (about 5 ml) of the tonic to the scalp for 4 months. As controls, a mixture of hair tonic with only one of the various plant extracts of the present invention, or a mixture prepared by removing the various plant extracts of the present invention by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Tables 1 to 6, and the numerical values in the table represent the number of persons. No one complained of scalp / hair abnormalities during the use period.

"Hair-growing / hair-growing effect" Efficacy: Very many downy hairs were formed. Slightly effective: slight downy hair was generated. Ineffective: No change from before use.

"Effect of improving hair feel" Efficacy: The gloss, tension, and smoothness of the hair were increased, and the comb-through was extremely improved. Slightly effective: The gloss, tension, and smoothness of the hair were slightly increased, and combing was slightly improved. Ineffective: No change from before use.

[0105]

[Table 1]

[0106]

[Table 2]

[0107]

[Table 3]

[0108]

[Table 4]

[0109]

[Table 5]

[0110]

[Table 6]

(Test Results) As shown in Tables 1 to 3, any one or more plant extracts of salvia and buttonpi of the present invention were further added to emisoso, ogon, hypericum, kouboku,
Comfrey, cherry, perilla, peonies, stevia, hange, bukuro, bodaiju, salvia, and a combination of one or more plant extracts selected from botan pips were found in many people with significant downy hair. Also, the hair growth and hair growth effects were strongly recognized as compared with the single plant extract compound.

(Test results) As shown in Tables 4 to 6, at least one plant extract of salvia and buttonpi of the present invention was further added to emisoso, ogon, hypericum, koboku,
Comfrey, cherry, perilla, peonies, stevia, hange, boukuro, bodaiju, salvia, and buttonpigs combine the use of one or more plant extracts to give the hair a shiny, firm, smooth, It improved and the hair feel was improved. In addition, it was also confirmed that the effect of improving the hair feel was stronger than that of a single plant extract compound.

[0113]

According to the present invention, any one of salvia and buttonpipi of the present invention is provided.
More than one species of plant extract, and more
Hypericum, Koboku, Comfrey, Sakura, Perilla,
A hair growth and hair growth agent combined with at least one plant extract selected from peonies, stevia, hange, boukuro, bodaiju, salvia, and bompii has an excellent hair growth and hair growth effect, and has a shiny and It gives tension and smoothness, improves comb passage, and is safe for humans and animals.
In addition, use for general foods and drinks is also possible.

[Brief description of the drawings]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing the regenerated hair area ratios of various plant extracts of salvia, botanic pipiens, fragrant magnolia, gougon, hypericum perforatum, kouboku, comfrey, cherry, perilla, peonies, stevia, hanger, bukuro, bodaiju, and minoxidil.

Fig. 2 Salvia extract is further combined with red bean, E. magnolia, Ogon, Hypericum perforatum, Kouboku, Comfrey,
It is a figure which shows the reproduction | regeneration hair area ratio at the time of containing one or more types of various plant extracts of a cherry tree, a perilla, a peony, a stevia, a hange, a bouquet, and a bodhiju.

FIG. 3 In addition to the salmon extract, red croaker, ogon, hypericum, kouboku, comfrey,
It is a figure which shows the reproduction | regeneration hair area ratio at the time of containing one or more types of various plant extracts of a cherry tree, a perilla, a peony, a stevia, a hange, a bouquet, and a bodhiju.

Claims (1)

[Claims] (1) A hair restorer / hair restorer containing the following (1) and (2) as essential components: (1) One or more plant extracts selected from salvia and buttoned peas. (2) One or more plant extracts selected from Emisoso, Ogon, Hypericum perforatum, Koboku, Comfrey, Sakura, Perilla, Peonies, Stevia, Hange, Bukuryou, Bodaiju, Salvia, Pontopi.