JP2003160486A - Oral hair grower and food/drink containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral hair grower having good hair growth promoting effect through its oral intake, and to provide food/drink containing the same. <P>SOLUTION: This oral hair grower contains as active ingredient(s) at least one substance selected from (A) fatty acids having carbon chain length with odd-numbered carbon atoms and derivatives thereof, (B) alcohols having carbon chain length with odd-numbered carbon atoms and derivatives thereof, (C) plants belonging to the genus Coleus or the like and extracts thereof, (D) seaweeds belonging to the genus Monostroma or the like and extracts thereof and (E) tocotrienol. The food/drink containing the oral hair grower is provided. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral hair-growing agent having an excellent hair growth-promoting effect by oral ingestion and foods and drinks containing the hair-growing agent. In the present invention, the food and drink means a wide range of orally ingested general foods, health foods, health functional foods, quasi drugs and medicines.

[0002]

2. Description of the Related Art Hair has a great influence on appearance and occupies a very important position in beauty, but alopecia is still a serious trouble because there is still no appropriate treatment. There are congenital and acquired types of alopecia, and many studies have been conducted on the cause and mechanism of development thereof, but there are many unclear points and it is currently desired to clarify them.

Conventionally, many hair-growing agents have been used for the prevention and treatment of alopecia. Examples of the medicinal components of these hair nourishing agents include assembly extracts, vasodilators such as vitamin E acetate, stimulants such as capsicum tincture, vitamins such as pantothenic acid and biotin, and hormone agents,
Anti-inflammatory agents, bactericides, etc. are used. It is also known that fatty acids, alcohols and derivatives thereof having an odd number of carbon chain lengths have an excellent hair-growing action (see, for example, Patent Document 1 and Patent Document 2).

However, the effects of these externally applied hair-growth agents are not always high and do not always give satisfactory results to users, and it is desired to provide a hair-growth agent having a further excellent hair-growth effect. ing.

Further, those approved as an oral hair-growth agent have a great limitation in use, such as the possibility of affecting the hormone balance in the body cannot be wiped out and they cannot be used by women. Furthermore, although there are foods that have been said to have a hair-growth effect for a long time, there are few oral hair-growth foods with scientifically proven effects, and the development thereof is strongly desired.

[0006]

[Patent Document 1] JP-A-59-27809

[Patent Document 2] JP-A-60-4113

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above problems in the prior art, meet the above demands, and solve the following problems. That is, an object of the present invention is to provide an oral hair-growing agent having an excellent hair growth-promoting effect by oral ingestion and foods and drinks containing the hair-growing agent.

[0008]

Means for Solving the Problems To solve the above-mentioned problems, the present inventor has conducted extensive research to find a substance having an excellent hair-growth effect and an excellent safety. (A) a fatty acid having an odd carbon chain length and its derivative, and (B) an alcohol having an odd carbon chain length and its derivative, whose effects are known,
(C) a plant such as Choleus and its extract, (D) a seaweed such as Human Egusa and its extract, and (E) a hair-growth agent containing one or more selected from tocotrienols as an active ingredient The present invention has been accomplished by finding that it has an excellent hair-growing action by ingestion orally, and that it can be widely applied by including these active ingredients in foods and drinks.

That is, the means for solving the above problems are as follows. <1> An oral hair nourishing agent having a hair growth promoting action by oral ingestion, containing one or more selected from the following components (A) and (E) as active ingredients. (A) Fatty acid having an odd carbon chain length and its derivative (B) Alcohol having an odd carbon chain length and its derivative (C) Genus Coleus, Ptychopetalum genus, Anemopaegma (Anemopaegma) genus, Solanau
m) genus, Stryphnodendon
dron) genus, Dalbergia
Genus, Cynara, Aniva (A
genus niba, mentha Mentha, genus Yanbarutsu genus (Leucas), genus Sedge (Bide)
ns), Pothomorphe
Genus, genus Eupatorium, genus Brosimun, genus Mikani
a) genus, Carapa genus, Tonka bean (Di
pteryx), Simarouba
Genus, genus Ficus, physalis (Physa)
lis) genus, Boerhavia
Genus, Guazuma and Date (Ziz)
plant selected from the genus yphus and its extract (D) genus Humanstroma, genus Ulva, genus Caetomomorpha
Genus, genus Bryopsis, cucumber (Cau)
Lerpa, Mill (Codium), Matsumo (A)
genus nalipus, Okinawa mozuku (Cladosi)
genus, Nemacystis genus, Lessonia genus, Durville (Dur)
Villea), Ainu seaweed (Alaria) genus,
The genus Ascophyllum, the genus Eisenia, the Ectocarp
genus us, genus Sargassum, genus Macrocystis, genus Amphiroa, genus Helitricaninote (Marg)
genus inisporum, Porphyr
a) genus, Ceramium genus, Rhodoglossum genus, Iridea genus, Gracilar genus
ia), genus Pterocladia, genus Acanthopeltis, genus Bonemaisonia, Rhody.
genus C. genus, Calliphyllum (Callophyll)
genus is, genus Becherella, genus Gloiopeltis, genus Gelid
ium genus, Halymenia genus, Ahnfeltia genus, Camphor
seaweed selected from the genus laephora and the genus Digenea and extracts thereof (E) tocotrienol <2>, further containing (F) a substance having an inhibitory action on 5α-reductase and / or (G) a cell activator <
1> is an oral hair-growth agent. <3> A food or drink containing the oral hair-growth agent according to <1> or <2>.

Further, in the present invention, the following modes are also suitable. <4> The oral hair-growth agent according to <1> or <2>, wherein the carbon chain lengths of the component (A) and the component (B) are odd numbers having 3 to 25 carbon atoms. <5> The above-mentioned <1>, in which the tocotrienol as the component (E) is an extract from pericarp and / or seed of a palm plant.
The oral hair-growth agent according to <2> or <4>. <6> The oral hair-growth agent according to <1>, <2>, <4>, or <5>, further containing (H) a plant extract having a blood circulation promoting action.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in more detail below. <Oral hair-growth agent> The oral hair-growth agent of the present invention comprises (A) a fatty acid having an odd number of carbon atoms and a carbon chain length thereof, and a derivative thereof,
From (B) an alcohol having an odd carbon number and a carbon chain length thereof, a derivative thereof, (C) a plant of the genus Coleus and its extract, (D) a seaweed of the genus Heptera and its extract, and (E) a tocotrienol It contains one or more selected ingredients as an active ingredient, and optionally contains (F) 5α.
-Contains a substance having a reductase inhibitory action, (G) a cell activator, (H) a plant extract having a blood circulation promoting action, and other components.

-(A) Fatty acid having an odd carbon chain length and derivatives thereof-The fatty acid having an odd carbon chain length of the component (A) is a carbon atom constituting a carbon chain. If the number is an odd number, it may be a saturated fatty acid or an unsaturated fatty acid, and the unsaturated fatty acid may contain a plurality of double bonds. In addition, even lower fatty acids such as propionic acid (carbon chain length 3) and valeric acid (carbon chain length 5) may be pentadecanoic acid (carbon chain length 15) or heptadecanoic acid (carbon chain length 17).
Higher fatty acids such as Among these, an odd number having 3 to 25 carbon atoms, more preferably an odd number having 9 to 19 carbon atoms is preferable. As such a fatty acid having an odd carbon chain length, for example, nonanoic acid, tridecanoic acid, pentadecanoic acid, etc. are suitable.

As the derivative of the fatty acid having an odd carbon chain length of the component (A), any derivative such as ester and amide can be used. However, it goes without saying that it is not possible to use an object that has a harmful effect on the human body. As an example of a preferable derivative, 1 type selected from the group of the following (a)-(wa) can be used individually or in combination of 2 or more types.

(A) A monoglyceride represented by the following general formula [I] or [II].

[0015]

[Chemical 1]

In the above formulas [I] and [II], R ¹ represents an even-numbered aliphatic hydrocarbon group having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms. Specific examples thereof include tridecanoic acid monoglyceride, pentadecanoic acid monoglyceride, and heptadecanoic acid monoglyceride.

(B) The following general formula [III] or [IV]
A diglyceride represented by.

[0018]

[Chemical 2]

In the above formulas [III] and [IV], R ² and R ³ are an even number of aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is Represents a straight-chain aliphatic hydrocarbon group having an even carbon chain length. Specifically, diglyceride undecanoate,
Examples thereof include tridecanoic acid diglyceride and pentadecanoic acid diglyceride.

(C) A triglyceride represented by the following general formula [V].

[0021]

[Chemical 3]

In the above formula [V], R ² , R ³ and R ⁴ are an even number of aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is Represents a straight-chain aliphatic hydrocarbon group having an even carbon chain length. Specific examples thereof include nonanoic acid triglyceride, tridecanoic acid triglyceride, pentadecanoic acid triglyceride, and monopentadecanoic acid diacetylglyceride.

(D) A fatty acid salt represented by the following general formula [VI]. (R ¹ COO) _n M ... [VI] In the above formula [VI], R ¹ represents an even-numbered aliphatic hydrocarbon group having 2 to 24 carbon atoms, and more preferably 8 to 18 carbon atoms. M
Represents a metal atom such as sodium, potassium, lithium, or ammonium ion such as ammonium or organic ammonium. Examples of the organic ammonium include monoethanol ammonium, isopropanol ammonium, diisopropanol ammonium, and triisopropanol ammonium. Note that n represents an integer corresponding to the valence of M. Specific examples thereof include potassium nonanoate and sodium pentadecanoate.

(E) An ester represented by the following general formula [VII]. R ¹ COOR ⁵ ... [VII] In the above formula [VII], R ¹ represents an even-numbered aliphatic hydrocarbon group having 2 to 24 carbon atoms, and more preferably 8 to 18 carbon atoms.
R ⁵ is a monovalent or divalent aliphatic alcohol residue having an even number of carbon atoms, a polyoxyethylene residue, a sorbitan residue,
Or represents a sucrose residue. Examples of the monohydric alcohol residue include alcohols having 1 to 18 carbon atoms such as methanol and ethanol. Specific examples include ethyl pentadecanoate and methyl nonadecanoate.

(F) A first amide represented by the following general formula [VIII]. R ¹ CONR ⁶ R ⁷ ... [VIII] In the above formula [VIII], R ¹ represents an even-numbered aliphatic hydrocarbon group having 2 to 24 carbon atoms, and more preferably 8 to 18 carbon atoms. R ⁶ and R ⁷ represent a hydrogen atom, an alkyl group having 1 to 18 carbon atoms or a hydroxyalkyl group. Specific examples thereof include pentadecanoic acid amide.

(G) Second represented by the following general formula [IX]
Grade amide.

[0027]

[Chemical 4]

In the above formula [IX], R ² and R ³ are even-numbered aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is an even-numbered carbon chain. Represents a linear aliphatic hydrocarbon group having a length. R
⁸ represents a hydrogen atom, an alkyl group having 1 to 18 carbon atoms or a hydroxyalkyl group. Specific examples thereof include N-acetylpentadecanoic acid amide.

(H) Third formula represented by the following general formula [X]
Amide.

[0030]

[Chemical 5]

In the above formula [X], R ² , R ³ and R ⁹ are an even number of aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is Represents a straight-chain aliphatic hydrocarbon group having an even carbon chain length. Specific examples thereof include N, N-diacetylpentadecanoic acid amide.

(B) Dibasic acids represented by the following general formula [XI] and salts thereof. HOOCR ¹⁰ COOH ... [XI] In the above formula [XI], R ¹⁰ represents a linear aliphatic hydrocarbon group having an odd carbon chain length, and for example, a carbon number such as a methylene group is 1 to 23, and An odd number of hydrocarbon groups of 1 to 17 is preferable. Specific examples thereof include 1,13-tridecamethylene dicarboxylic acid.

(G) A sterol ester represented by the following general formula [XII].

[0034]

[Chemical 6]

In the above formula [XII], R ¹ has 2 to 2 carbon atoms.
It represents an even number of aliphatic hydrocarbon radicals of 24, preferably 8-18. Specific examples thereof include cholesterol pentadecanoate.

(L) A phospholipid represented by the following general formula [XIII].

[0037]

[Chemical 7]

In the above formula [XIII], R ² and R ³ are an even number of aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is an even number carbon chain. Represents a linear aliphatic hydrocarbon group having a length. X ₁ represents a choline residue, an ethanolamine residue, a serine residue, or an inositol residue. For example, phosphatidylcholine is a choline residue, phosphatidylethanolamine is an ethanolamine residue, phosphatidylserine is a serine residue, and phosphatidylinositol is an inositol residue.
Specifically, 1,2-dipentadecanoyl-glycero-
3-phosphorylcholine etc. are mentioned.

(2) Phosphatidic acid represented by the following general formula [XIV].

[0040]

[Chemical 8]

In the above formula [XIV], R ² and R ³ are an even number of aliphatic hydrocarbon groups having 2 to 24 carbon atoms, more preferably 8 to 18 carbon atoms, and at least one of them is an even number carbon chain. Represents a linear aliphatic hydrocarbon group having a length.
Specifically, 1,2-dipentadecanoyl-glycero-
3-phosphoric acid etc. are mentioned.

(W) A sphingolipid represented by the following general formula [XV].

[0043]

[Chemical 9]

In the above formula [XV], R ¹ has 2 to 2 carbon atoms.
4, more preferably an even number of 8 to 18 aliphatic hydrocarbon groups, phosphoric acid residues, or amine base residues. Specifically, N-pentadecanoyl sphingosine-1-phosphoryl ethanolamine and the like can be mentioned.

The fatty acid having a carbon chain length of odd number and the derivative thereof as the component (A) can be blended in the hair-growing agent at any concentration. Usually, it depends on the product form and the frequency of use, but preferably 0.01 based on the total amount of the hair-growth agent.
~ 20 mass%, more preferably 0.1-10 mass%
Each can be blended. If the blending amount is less than 0.01% by mass with respect to the total amount of the hair-growing agent, the intended effect of the present invention may not be sufficiently exhibited. On the other hand, if the blending amount exceeds 10% by mass, it becomes gradually difficult to dissolve in the solvent, and if it exceeds 20% by mass, formulation becomes extremely difficult, which is not preferable.

-(B) Alcohol having an odd carbon chain length and its derivative- (B) Alcohol having an odd carbon chain length includes the carbon atoms constituting the carbon chain. If the number is an odd number, it may be saturated alcohol or unsaturated alcohol. Moreover, the unsaturated alcohol may contain a plurality of double bonds. Furthermore, even lower alcohols such as propyl alcohol (carbon chain length 3) and aluminum alcohol (carbon chain length 5) can be used in higher grades such as tricosyl alcohol (carbon chain length 23) and pentacosyl alcohol (carbon chain length 25). Alcohol may be used. Further, the hydroxyl group may be bonded to any carbon atom. Of these, an odd number having 3 to 25 carbon atoms, more preferably 9
It is preferable to use an odd number of ˜19. Examples of such alcohols having an odd carbon chain length include undecyl alcohol, tridecyl alcohol, pentadecyl alcohol, and heptadecyl alcohol.

The component (B), which is an alcohol derivative having an odd carbon chain length, is typically an ester or etherified product of an alcohol having an odd carbon chain length. Among them, specifically, those shown in the following (i) and (ii) are preferable.

(I) An ester compound represented by the following general formula [XVI]. R < ¹¹ > -OR < ¹² > ... [XVI] In the above formula [XVI], R < ¹¹ > is a carbon chain length alcohol residue having an odd number of carbon atoms, preferably 3 to 25 carbon atoms, more preferably 9 to 9 carbon atoms. 19 odd alcohol residues are shown. R ¹² is a fatty acid residue, preferably one having a chain length of 2 to 24 carbon atoms, and examples thereof include organic acid residues such as succinic acid, citric acid, fumaric acid, lactic acid, pyruvic acid, malic acid and oxaloacetic acid. A group or an inorganic acid residue such as phosphoric acid is shown. The esterified product may contain, in one molecule, a carbon chain length alcohol residue having an odd number of 2 or more carbon atoms, such as an ester with succinic acid. Specifically, nonyl acetate, undecyl succinate, pentadecyl citrate and the like can be mentioned.

(Ii) An ether compound represented by the following general formula [XVII]. R < ¹¹ > -OR < ¹³ > ... [XVII] In the above formula [XVII], R < ¹¹ > is a carbon chain length alcohol residue having an odd number of carbon atoms, preferably 3 to 25 carbon atoms, and more preferably 9 to 9 carbon atoms. 19 odd alcohol residues are shown. R ¹³ is an alcohol residue, preferably 2 to 2 carbon atoms
4 shows a chain length of 4, for example, polyhydric alcohol residues such as glycerin, polyglycerin, ethylene glycol, propylene glycol and butanediol, or sugar residues such as glucose, ribose, galactose, arabinose, mannose, xylose, sorbitol and mannitol. Indicates a group or the like. The etherified product may include a carbon chain length alcohol residue having an odd number of 2 or more carbon atoms in one molecule, such as an etherified product with glycerin. Specifically, triundecyl glyceryl ether,
Examples include tripentadecyl glyceryl ether.

The fatty acid and alcohol derivatives having an odd carbon chain length used in the hair-growing agent of the present invention are the above-mentioned odd numbers of 3 to 25 carbon atoms, more preferably 9 to 19 carbon atoms.
It is important to have an odd number of carbon chain lengths. Therefore,
For example, the residues of the above derivatives may have various substituents. Needless to say, it should not adversely affect the human body.

The alcohol having a carbon chain length of odd number and the derivative thereof as the component (B) can be blended in the hair-growing agent at any concentration. Usually, it depends on the product form and the frequency of use, but is preferably 0.
It may be added in an amount of about 01 to 20% by mass, more preferably 0.1 to 10% by mass. If the blending amount is less than 0.01% by mass with respect to the total amount of the hair-growing agent, the intended effect of the present invention may not be sufficiently exhibited. On the other hand, if the blending amount exceeds 10% by mass, it becomes gradually difficult to dissolve in the solvent, and if it exceeds 20% by mass, formulation becomes extremely difficult, which is not preferable.

-(C) Plants and Extracts Thereof-As the plants of the above-mentioned (C) component, Coleus (Coleu) is used.
s) genus, Petychopetalu
m) genus, Anemopaegma
Genus, Solanum genus, Stryphnodendron genus, Dalbergia genus, and thistle (Cyn)
genus ara, genus Aniba, mint (Men)
genus tha), genus Yanbarusu (Leucas),
Bidens genus, Potorumofe (Po
genus Thormorphe, Eupatato
genus rum, genus Brosimun, genus Mikania, Carapa
Genus, Tonka bean (Dipteryx), Simalva (S
genus imarouba, genus Ficus, physalis, Physalis (Bo)
Examples include plants selected from the genus erhavia, the genus Guazuma and the genus Zyzypus.

The plant of the genus Coleus is
It has long been used as a folk medicine in regions such as India, Arab, Africa, and Brazil. The Coleus (Col)
eus) plants are not limited to those cultivated and grown naturally in these areas, and for example, they can be used without any difference in terms of composition and effectiveness from the ones obtained from the above areas. Coleus cultivated in
s) It may be a genus plant. Further, it is also possible to use an organ obtained by a tissue culture method such as microtuber, adventitious bud, adventitious root, hairy root, or callus. Among the Coleus plants, Coleus forskolli Briq.,
Coleus parviflors
lorus Benth. ), Coleus ambinicus Lour.
Is particularly preferable from the viewpoint of hair-growth effect. Coleus
Coleus forskolli
Briq. ) Is used as a medicine for heart, respiratory and nervous system diseases or abdominal pain, and is also eaten as a pickle in India. Coleus parviflors (Co
leus praviflourous Benth. )
Has a root similar to potato and is also used for food. The Coleus aboinix
mboinicus Lour. ) Is effective against sunstroke, hemorrhoids, etc., and is also used for flavoring food. Regarding the Coleus plant, its plant body and extract include forskolin and its biosynthetic intermediates and in-vivo metabolites, which may be used after separation and purification by chromatography or the like. .

The Petitopepet (Ptychope)
The plant of the genus talum) has been used in the South American Amazon for a long time as a folk medicine for tonics, digestion promotion, antidiarrheal, etc. Among them, the local name "Mui Lapu Ama" (Ptycho
petalum olacoides Benth. )
Has an excellent hair growth promoting action and is particularly desirable.

The anemopaeg (Anemopaeg)
Ma) is mainly used in Brazil, and the local name is "Catauba" (Anemopaeg).
It is preferable because it has an excellent hair growth promoting action on maarvense. The plant of the genus Solaum is mainly used for jaundice and sweating in Brazil and Argentina. Among them, the local name is “Julbeba” (Solanum).
Paniculatum) has an excellent hair growth promoting action, which is preferable. The strifnodendron (Type)
The plant of the genus hnodendron is mainly used in Brazil for hemostasis, hepatitis, and tonicity. Among them, the local name is "Barbatimon Verdadeiro" (Styphnoden).
It is preferable because it has an excellent hair growth promoting action on dron adstingens).

The aforesaid Tsutsuikachi (Dalbergia)
The genus plant is used extensively mainly in the South American Amazon and Peru. Among them, the local name is "Veronica" (Dalberg).
It is preferable because it has an excellent hair growth promoting action on iasubcymosa). Thistle Thistle (Cynar
a) The genus plant is mainly used for enhancing liver function in the Mediterranean Sea. Among them, the local name is “Arcashofura” (Cynara).
has an excellent hair growth promoting action,
preferable. The genus Aniba is distributed in the Amazon region and is used for aroma, tonic, etc.,
Among them, the local name "Casca Preciosa" (Aniba
It has an excellent hair growth promoting action and is preferable. The plant of the genus Mentha is
It is mainly used in Southern Europe and the Caucasus region, and the local name is “Orteran Pimenta” (Mentha).
Piperita) has an excellent hair growth promoting action,
Especially desirable.

The above-mentioned Yanbaru Tsuruhakka (Leucas)
Genus plants are distributed from Africa to India,
About 150 species are known. Above all, in Brazil, the local name is "Cordon de Frade" (Leucas mart).
(inicesis) is used as a decoction for tonicity, stomach pain, stomach ache, etc., but it is also effective for promoting hair growth and is particularly desirable. The Sendengsa (Bidens)
The genus plant is widely distributed mainly in the United States and has about 23
0 species are known. Above all, in Brazil, the local name "Calapiscio de Agulla" (Bidens bipi)
nata), "Picon" (Bidens pilos)
Although a) and the like are used for jaundice, swelling, and the like, "Picon" (Bidens pilosa) has a hair growth promoting action and is particularly preferable. The plant of the genus Pothomorphe is mainly used in tropical America for diuresis, stomach ache, and liver disease. Among them, the local name is “Phothomorpheum”.
Bellata) has an excellent hair growth promoting action and is particularly desirable.

The above-mentioned Eupatoriu
m) The genus plant is widely distributed in the Americas mainly in the world, and about 1200 species are known. Especially in Brazil,
Local name "Maria Breta" (Eupatorium)
ballotaefolium), "Camberer" (E
upadium laevigatam), "Aiyapana" (Eupatorium tripline)
Rve) is a tumor, a hemostasis, a decoction tonic, a healthy stomach,
It is used to prevent diarrhea, but especially "Aiyapana"
(Eupatorium triplinerve) has a strong hair growth promoting action and is particularly desirable. The Brosimum plant is used in Brazil for tonics, blood purification, rheumatism, and the like. Among them, the local name "Muiirapiranga" (Brosimumacutifo) is used.
is particularly desirable because it has an excellent hair growth promoting action.

The plants of the genus Mikania are widely distributed in the Americas, and about 300 species are known. Especially in Brazil, Guaco (Mikan)
iacordifolia), Cipo Caberudo (M
ikania hirsutissima), scriju (Mikania lindleyana), etc.
It is used as a decoction for hepatitis, rheumatism, bronchitis, etc.
Leyana) has an excellent hair growth promoting action and is particularly desirable. The plant of the genus Carapa is mainly distributed in the Amazon region and prevents diarrhea from bark, anthelmintic, antipyretic,
It is used as a wound medicine and seeds for hepatitis and rheumatism. Among them, the local name "Andy Rover" (Carapa
guienensis) has a hair growth promoting action,
Especially desirable. The above-mentioned plant of the genus Dipteryx is mainly used in Brazil as a decoction for tonic, sweating, and menstruation. Among them, the local name "Kumaru" (Di
pteryx Alata Vogel), “Cumarurana” (Dipteryx op)
postifolia Wild. ) Has an excellent hair growth promoting action, which is particularly desirable.

The above-mentioned plant of the genus Simarouba is mainly used in tropical America for tonic, antipyretic and diarrhea prevention. Among them, the local name "Malpauba" (Simar) is used.
ouba amara) has an excellent hair growth promoting action, and is particularly preferable. The Ficus plant is mainly used in tropical America for anthelminth and jaundice,
Among them, the local name "Coinguover" (Ficus ins
pida) has an excellent hair growth promoting action, and is particularly preferable. The Physalis plant is mainly used in tropical America for tonicity, liver disease, and spleen disease. Among them, the local name "Physalis" is used.
gulata) has an excellent hair growth promoting action, and is particularly preferable.

The aforesaid Boerhavi
a) The genus plant is mainly used in tropical America for diuresis, hepatitis and nephritis. Among them, the local name is “Elva Toston”.
(Boerhavia coccinea) has an excellent hair growth promoting action, and is particularly preferable. The plant of the genus Guazuma is mainly used in tropical America for the prevention of liver disease and hair loss, and among them, the local name “Mutamba” (Guazuma ulmifolia) has an excellent hair growth promoting action, and is particularly preferable. The plant of the genus Zyzyphus is mainly used in Brazil for hair tonic and liver disease, and in particular, the local name "Joyzeiro" (Zyiffus joazeiro) has an excellent hair growth promoting action and is particularly preferable.

As the plant of the component (C), its wood part, heartwood part, bark part, branch part, leaf part, root part, seed part, fruit part, flower part and the like can be used, and dried by freeze-drying or the like. It may be made into a powder or adjusted to a paste.

-(D) Seaweed and its extract-As the seaweed of the component (D), human Exa (Mono) is used.
genus stroma, genus Ulva, genus Caetomomorpha, briops
is), Ivy (Caulerpa), Mill (C
genus Odium, genus Analipus, genus Cladosiphon, mozuku (N)
genus emacystis, Lessonia (Lessoni)
a) genus, Durvillea genus, Ainu seaweed (Alaria) genus, Ascophyllum (Asco)
genus phyllum, genus Eisenia, genus Ectocarpus, genus Honda straw (S
genus argassum, Macrocystis (Macro)
genus cystis), genus Amphiroa,
The genus of Heli Tricaninote (Marginisporum),
The genus Porphyra, Ceram
ium), Rhodoglos
genus sum, Iridea genus, Gracilaria genus, Pterosa
genus Cladia, Yukiiri (Acanthopelt)
genus is, genus Kashenori (Bonnemaisoni)
a), the genus Rhodymenia, the genus Callophyllis, the genus Blac
herella), Funori (Gloiopelti)
s) genus, Gelidium genus, Isohyana genus (Halymenia) genus, Ahn felti
A seaweed selected from the genus a), the genus Campylaephora, and the genus Digenea is used.

[0064] Said human stroma (Monostroma)
The seaweed of the genus is,
nitidum) is preferred. Said human exa (Mo
Nostro nitidum) is distributed in the central and southern parts of the Pacific coast. The algal bodies are circular and thin and soft, and they grow on the rocks above the intertidal zone from winter to early spring and are edible. As the seaweed of the genus Ulva, Ulva pertusa, Ulva sublititalis, and sea lettuce are preferred, and the seaweed is distributed in the coasts of Japan and Korea, for example. The body is membranous and has many large and small holes,
It grows on rocks in the lower part of the intertidal body and is partly edible. Examples of the seaweed of the genus Caetomomorpha include Caethomorpha cras.
sa) is preferred. The above-mentioned lizard (Caetomo)
rpha crassa) is widely distributed in Japan, the Korean Peninsula, and the Atlantic Ocean. The algal bodies are columnar, light green in color, and slightly hard in quality.

Examples of the seaweed of the genus Bryopsis include Bryopsis plumos.
a) is preferred, and this seaweed is distributed on the coasts of various parts of the world, and the algal bodies have soft twigs on both sides of the main axis and are soft, and grow on rocks near the low tide line. The seaweed of the genus Caulerpa is preferably Culerpa lentillifera, and this seaweed is distributed in the Philippines, Micronesia, and the Red Sea. Take out the branched temporary root thread. Examples of the seaweed of the genus Codium include Codi
um fragile) is preferred, and this seaweed is distributed in various parts of Japan, Korea, Australia, the Pacific coast of North America, etc., and the alga body is columnar and stands upright and branches regularly in a fork shape. It grows on rocks in the belt.

Examples of the seaweed of the genus Analipus include matsumo (Analipus japonic).
This seaweed is distributed on the Pacific coast north of eastern Japan, North Korea, Karafuto, Kuril coast, etc., and the alga body resembles pine shoots and is found on rocks and shells in the middle of the intertidal body. It grows and is edible. The Okinawa mozuku (Clado
As a seaweed of the genus Siphon, Okinawa mozuku (C
Ladosiphon okamuranus) is preferable, and this seaweed is distributed in the Nansei Islands. The alga is characterized by columnar, string-like, soft and feather-like branches, which grow in the lower part of the intertidal body and are edible. The above-mentioned module (Nemacy)
As a seaweed of the genus stis,
This is a seaweed that is distributed along the Pacific coast, the Seto Inland Sea, the Sea of Japan coast, etc., and the algal cells are columnar, thin, soft, and sticky, and attach to other seaweeds near the low tide line. It grows and is edible.

As the seaweeds of the genus Lessonia, there are Lessonia nigresense (Lesso).
nia nigrescens) is a seaweed of the genus Durvillea.
Antarctica (Durvillea antarc)
tica) is preferred. The Ainu sea turtle (Alari
a) Seaweeds belonging to the genus Ainu seaweed (Alaria)
Praelonga) is preferred, and this seaweed is distributed in eastern Hokkaido, Kamchatka and the Bering Sea and is edible. The alga body is 1.5 to 4.5 m long and the quality of the body is leather and the color is brownish olive. As the seaweed of the genus Ascophyllum, Ascophyllum nodosum (Ascophyllum n
Odosum) is a seaweed of the genus Eisenia (Eisenia bicycl).
is) is a seaweed of the genus Ectocarpus and is Ectocarpus s.
iliculosus) is preferred.

Examples of the seaweed of the genus Sargassum include Sargassum F.
ulvellum, Sargassu
mconfusum), and these seaweeds are distributed from the temperate zone to the temperate zone of the world and differentiate into a very large number of species. The Macrocystis (Macrocyst)
As a seaweed of the genus is, Macrocystis (Macr)
cystis pyrifera) is preferred. The seaweed of the genus Amphiroa is preferably Amphiroa dilatata, and the seaweed is distributed in the Pacific coast, the Sea of Japan coast, Australia, etc. It contains calcium carbonate and grows on rocks in the dip zone.

The above-mentioned heritage caninote (Marginis)
As a seaweed of the genus Porum, helitricaninote (M
arginisporum crassisismu
m) is preferable, and this seaweed is distributed along the Pacific coast, the Sea of Japan coast, and the Korean Peninsula coast, and the alga body is flat, feather-shaped, fan-shaped, hard, and contains calcium carbonate, and grows on rocks near the low tide line. To do. Examples of the seaweed of the genus Porphyra include Porphyra te.
nera), Susabinori (Porphyra yezo)
ensis) is preferred. For example, the Porphyra tenera is located on the Pacific coast.
It is distributed on the Korean Peninsula, China, etc., and the alga is leaf-shaped, and it grows in the upper part of the intertidal zone and is also cultivated for food. Examples of the seaweed of the genus Cerium include Ceramium boydeni.
i), squid (Ceramium kondoi), cerium rubrum (Ceramium rubru)
m) is preferred. For example, the above-mentioned Cerami
um boydenii) is distributed along the Pacific coast, the Sea of Japan coast, etc., and the algal bodies are filamentous, columnar, and thin, and grow by being entangled with Honda strawberries near the low tide line.

[0070] The Rhodogl
As the seaweed of the genus Ossum), Rhodoglossum japonicum is preferable, and the seaweed is Hokkaido coast, northern Pacific coast,
It is distributed in safflowers and the like, and the algal bodies are membranous, thin and long egg-shaped or wedge-shaped, and grow in the lower intertidal zone. The seaweeds belonging to the genus Iridea include Iridea cordata and Iridea cornuca.
opiae), Iridia Iridae
a edulis), Iridia Frasida (Iri)
daea flaccida) is preferred.

Examples of the seaweed of the genus Gracilaria include Gracilaria v.
errucosa), dragonfly (Gracillar)
iaedulis) is preferred. For example, the above-mentioned Gracilaria verrucosa is widely distributed in Japan, Sakhalin, Korea, and Taiwan, and the alga is columnar. Examples of the seaweed of the genus Pterocladia include the genus Pterocladia cap.
illacea), Pterocladia tenuis (P
Terocladia tenuis) is preferred. For example, the above-mentioned Pterocladia cap
Illacea) is distributed along the coasts of various parts of Japan, Taiwan, and the Pacific coast of the United States. Its algal bodies are similar to those of Maxusa, but they are a little thin, and they grow on the rocks from the lower part of the intertidal zone to the gradual zone and are used as raw material for agar.

The above-mentioned Yukiiri (Acanthopelti)
As a seaweed of the genus s), Yukiiri (Acanthope)
Ittis japonica) is preferred, and this seaweed is distributed in the central Pacific Ocean and southward, and the alga body is columnar, has crescent-shaped leaves around the branches, and grows on rocks in the dip zone. Examples of the seaweed of the genus Bonnemaisonia include Bonemaisonia.
hamifera) is preferred, and this seaweed is
It is distributed in Korea and has recently been introduced to both banks of North America and Europe. The gametophyte is entangled with other seaweeds, and the branches are cylindrical and branched, and the outer shape is a triangular pyramid and the height is 10 to 15 cm.
Grows next to it. The dulls (Rhodymeni
a) Seaweeds of the genus include Rhodymenia
This seaweed is distributed around Hokkaido, northern Pacific coast, Korean Peninsula, etc., and the algal bodies are membranous, wedge-shaped, fan-shaped, palm-shaped, etc., on the rocks from the lower intertidal zone to the gradual zone. It grows in and is also used for food.

The above-mentioned Callosophyllum (Callophyll)
is) seaweeds such as Callophyllis variegata,
Nether Shinoto Callophyllus a
ndata), Japanese buckthorn (Calloph)
yllis japonica), Calliphyllus crispata,
Calliphyllum (Callophyllis firma) is preferred. For example, the above-described
Lophyllis japonica) is distributed in the central, southern, and Korean peninsulas of the Pacific coast, and algal bodies are membranous, irregularly branched, and fan-shaped, and grow on rocks in the dip zone.

The seaweeds belonging to the genus Becherella include Becherella s.
ubcostata) is preferred, and this seaweed is distributed in the south and southwestern islands of the central Pacific coast and the like, and the algal cells are flat and celluloid, and grow on the seabed at a depth of 10 to 20 m.
It is also a raw material for agar. The Funori (Gloipelti
As a seaweed of the genus s), there are
tis furcata) is preferred, and this seaweed is distributed along the coasts of various parts of Japan, and the algal bodies are cylindrical hollows,
It grows on rocks near the high tide and is used as a glue for clothes.

As the seaweed of the genus Gelidium, the species Gelidium amani
i), Onyx (Gelidium japonicu)
m), Oobusa (Gelidium pacificu)
m), geridium latiforium (Gelidi)
um latifolium) is preferred. For example, the above-mentioned Maxa (Gelidium amansii) is distributed along the coast, Indian Ocean, Atlantic Ocean, etc., in various parts of Japan,
The algal bodies are rather flat, thin and have wing-like long and short branches, grow on rocks in the gradual zone from around the low tide line, and are important raw materials for agar.

Examples of the seaweed of the genus Halymenia include Halymenia d.
urvillalai), Isonohana (Halymeni)
afloresia), peregrine falcon (Halymeni)
a dilatata) Marbagsa (Halymeni)
a routunda), Stinkweed (Halym)
Enia acuminata) and Halimenia formosa are preferred. For example, the above-mentioned Halymenia f
Loresia) are distributed in the southern Pacific coast and Nansei Islands, and the algal bodies are membranous and foliate, and grow from the low tide line to the gradual zone.

The seaweeds of the genus Ahnfeltia include Ahnfeltia pic.
ata) is preferred, and this seaweed is distributed on the east coast of Hokkaido, Sakhalin, etc., and the alga body is linear and columnar, hard, and grows on the seabed in the gradual zone, and is a raw material for agar. The egonori (C
As a seaweed of the genus amplaephora, there is a species of Camphoraephora hypnaeoid.
es) is preferable, and this seaweed is distributed in the Pacific coast, the Seto Inland Sea, etc., and the alga body is filamentous and columnar, and it grows by being caught by other seaweeds that grow near the low tide line and is also edible. is there. As the seaweed of the genus Maci (Digenea), macri (Digenea simple) is preferable, and this seaweed is distributed in the southern Pacific coast, the Southwest Islands, etc., and the algal cells have columnar dense branches with thin hairs. , It grows on rocks in the gradual zone from around the low tide line, and is a raw material for medicinal insects.

Further, the seaweed as the component (D) may be made into a dry powder by freeze-drying, or may be prepared as a paste.

-Plant extract and seaweed extract-As the solvent for obtaining the plant extract and the seaweed extract, for example, methanol, ethanol, butanol, hexane, heptane, cyclohexane, ethyl acetate, Commonly used organic solvents such as acetone and water are mentioned, and among these solvents, methanol, ethanol and water are particularly preferable. These may be used alone or in combination of two or more.

The extraction treatment can be carried out by a conventional method at a temperature of usually about 3 to 70 ° C. In addition to the solvent extraction, an extract obtained by supercritical extraction in which carbon dioxide gas is in a supercritical state can be used as well. At this time, hexane, ethanol or the like can be used as an extraction aid.

The extract may be used as it is, may be used as a dilute solution or a concentrated extract, or may be a dry powder by freeze-drying or the like, or may be prepared as a paste.

The total amount of the plant (C) and the extract thereof, and the seaweed (D) and the extract thereof is 0.00000, based on the total weight of the hair restorer.
1 to 10.0% by mass, preferably 0.0001 to 5.0
It is% by mass. If the compounding amount is less than 0.000001% by mass, no sufficient effect can be expected, while 10.0% by mass
If it exceeds the range, formulation may be difficult, or the compounding stability may not be maintained.

— (E) Tocotrienol— Examples of the tocotrienol as the component (E) include, for example:
Examples thereof include α-tocotrienol, β-tocotrienol, γ-tocotrienol and δ-tocotrienol, and one or a mixture of two or more thereof can be used. These tocotrienols have d
There are-, 1-, and d1-type isomers, but any of them can be used in the present invention.

In a preferred embodiment of the present invention, in the triangular chart, the mass ratio of α-tocotrienol: γ-tocotrienol: δ-tocotrienol is A (95: 4.
8: 0.2), B (0.5: 99: 0.5), C (5:
45:50) and D (46: 4: 50). Within this range, a very excellent hair-growth effect is exhibited.

The tocotrienol as the component (E) can be obtained by any method such as pressing a natural product, extracting from a natural product, or synthesizing it, but generally it is extracted from the pericarp and / or seed of a palm plant. In general, tocotrienols obtained from natural product extracts are a mixture of tocotrienols. Any palm plant can be used as long as it belongs to the family Palmae, but oil palms of the oil palm genus are preferable, and particularly, Elaeis g native to West Africa.
uineensis, Elaeisolei from Latin America
fera and Elaeis odora, Elaeis
dur, a hybrid species of guineasis
Preferred are a, pisifera and tenera.

Tocotrienol (palm oil tocotrienol) obtained by adding water after extraction and separating and purifying by chromatography is particularly preferable. Such palm oil tocotrienol is generally α-tocotrienol or β-tocotrienol.
A mixture of tocotrienols, γ-tocotrienols and δ-tocotrienols. Since β-tocotrienol is a trace, the composition of such a mixture usually corresponds to the preferred range mentioned in the above-mentioned triangular diagram.

The compounding amount of the above-mentioned component (E), tocotrienol, is 0.001 to 1 based on the total mass of the hair-growing agent.
It is 0.0% by mass, preferably 0.01 to 5.0% by mass.

-Other Active Ingredients- (F) A substance having an inhibitory action on 5α-reductase (having an inhibitory action on 5α-reductase) is another active component that can be incorporated into the hair-growing agent of the present invention. (Including plant extract), (G) cell activating agent, (H) plant extract having a blood circulation promoting action, and the like.

As the substance having the 5α-reductase inhibitory action of the component (F), sage, thyme containing polyphenols such as tannin and flavonoid,
Rosemary, ethanol such as hops, hydrous ethanol, 1,3-butylene glycol, hydrous 1,3-butylene glycol or purified water extract, eugenol,
In addition to clove oil, which is an essential oil containing a large amount of isoeugenol, henna leaves (laurin), etc., purple roots (shikonin), rice germ (ferulic acid), legumes such as coccuse seba, rosewood, etc. Examples thereof include 3-butylene glycol or a plant extract having a 5α-reductase inhibitory action obtained by extraction with a water-containing solvent or purified water thereof. In addition, a saw palmetto extract component, finasteride, and the like may be added.

It is sufficient that at least one substance having the 5α-reductase inhibitory action of the component (F) is contained, and the content thereof is 0.001 based on the total amount of the hair-growing agent.
The content is in the range of 10.0% by mass, preferably 0.01 to 3.0% by mass.

Examples of the cell activator of the component (G) include vitamins (retinol, retinal, vitamin A ₁ acid, vitamin A ₁ acid ester, retinol acetate, retinol palmitate, β-glycyrrhetinic acid, thiamine nitrate, Thiamine hydrochloride, thiamine disulfide compound, riboflavin, flavin nucleotide, flavin tetrabutyrate, riboflavin tetranicotinate, dicaprylic acid pyridoxine, pyridoxine hydrochloride, pyridoxal hydrochloride, pyridoxamine hydrochloride, cyanocobalamin,
Nicotinic acid, nicotinic acid amide, benzyl nicotinate,
Pantothenic acid, pantothenate, pantothenyl alcohol, pantothenyl ethyl ether, biotin, ascorbic acid, ascorbate, ascorbate,
Vitamin Ds, tocopherols, tocopherol acetate,
Ubiquinone, plastoquinone, vitamins K, etc., choline, essential fatty acids (linoleic acid, linolenic acid, arachidonic acid), eicosatrienoic acid, female hormones, corticosteroids, antihypertensive agents (minoxidil, diazoxide, etc.), TCA cycle Related substances (c-AMP, succinic acid, citric acid, ATP, FAD, NAD, NADP, L-malic acid, methylmalonyl CoA, fumaric acid, succinyl C
oA, coenzyme A, GDP, GTP, ADP, AM
P, oxaloacetate, acetyl CoA, etc.), plant extracts other than the above plant extracts (hinokitiol, aloe extract,
Examples thereof include salamander extract, red ginkgo extract, ginseng extract, etc., and synthetic medicinal components (carpronium chloride, etc.). These can be used alone or in combination of two or more.

The content of the cell activator as the component (G) is 0.001 to 10.0% by mass, preferably 0.01 to 3.0% by mass, based on the total amount of the hair-growth agent.

Examples of the plant extract having the blood circulation promoting action of the component (H) include arnica (flavonoid,
Essential oils), assemblage (sertiamarin, sertianoline), cephalatin (cephalantin, isotetrandrin, methylisochondrodendrin), ethanol such as Hikiokoshi (emmain, indoneal, tannin), hydrous ethanol, 1,3-butylene Extracts and essential oils with solvents such as glycol, hydrous 1,3-butylene glycol, purified water (cardamom oil, eucalyptus oil, peppermint oil, fennel oil, turpentine oil, spearmint oil,
Melissa oil, fannetol, phytol, el-menthol and the like). Among these, hydrous ethanol or 1,3-butylene glycol extract such as Assemblies and Hikioshi, and Melissa oil and spearmint oil, which are essential oils, are particularly preferable.

The content of the plant extract having the blood circulation promoting action of the component (H) is 0.00 based on the total amount of the hair-growing agent.
1 to 10.0% by mass, preferably 0.01 to 3.0% by mass
Is.

The oral hair-growing agent of the present invention comprises the above (A) to
Although one of the (E) ingredients alone exhibits an excellent hair-growing effect by oral ingestion, (A) to (E)
Two or more selected from the ingredients, if necessary (F)
By containing the (H) component as an active ingredient, a more excellent hair-growth effect is produced. Suitable combinations include, for example, the (A) component and / or (B) component and the (C) component. Component and / or combination with (D) component, combination of (A) component or (B) component, (C) component or (D) component and (E) component, (A) component or (B) component Alternatively, the component (E) and the component (C) or (D)
Combinations with ingredients, and the like.

-Other Components- The oral hair-growth agent of the present invention may contain any component other than the above-mentioned active components depending on the purpose of use. Examples of such optional components include purified water, ethanol, polyhydric alcohols, celluloses, surfactants, oils and fats, ester oils, amino acids, keratolytic agents, polymer resins, coloring materials, fragrances, and UV absorption. Agents and the like. Examples of the polyhydric alcohol include glycerin, 1,3
-Butylene glycol, polyethylene glycol, sorbitol, propylene glycol, pentaerythritol and the like. The optional components are not limited to these.

Examples of the celluloses include hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and the like. Examples of the surfactant include sorbitan fatty acid esters (sorbitan monolaurate, sorbitan monooleate, etc.), polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil mono or triisostearate, and the like. Examples of the oils and fats include polyhydric alcohol fatty acid ester (tri-2
-Glycerin ethylhexanoate, trimethylolpropanoic acid triisostearate, etc.), safflower oil, evening primrose oil, jojoba oil, and the like. Examples of the ester oil include unsaturated fatty acid alkyl ester (ethyl oleate, isopropyl linoleate, etc.), methyl myristate, isopropyl myristate, and amino acids include methionine, serine, glycine, cystine, and the like. . Examples of the keratolytic agent include salicylic acid, resorcin, and the like. Examples of the polymer resin include amphoteric, cationic, anionic and nonionic polymers. As the ultraviolet absorber, octyl methoxycinnamate (neoheliopan A
V), oxybenzone, urocanic acid and the like.

<Foods and Beverages> The hair-growing agent of the present invention has a markedly excellent hair growth-promoting effect upon oral administration, and is added to various raw materials and preparations of foods, and a general production method is used. It can be processed and manufactured into various foods and drinks. In the present invention, the term “food and drink” means a wide range of foods that are orally ingested such as general foods, health foods, foods with health claims, quasi-drugs and drugs.

In this case, the amount of the hair-growth agent added varies depending on the food or drink to be added and cannot be specified unconditionally, but it may be added within a range that does not impair the original taste of the food or drink. Usually 0.01 to 50% by mass, preferably 0.
The amount is in the range of 1 to 10% by mass, and in the case of tablets and capsules food and drink, it is usually added in the range of 5 to 100% by mass.

The forms of food and drink containing the hair-growth agent of the present invention include beverages (tea, juice, soft drinks, favorite beverages,
Lactic acid bacteria beverages), jellies, dairy products, confectionery, long-term storable foods (dry food, bottled foods, canned foods, retort foods, etc.), seasonings, etc. it can.

The forms of the oral hair-growing agent of the present invention include tablets, capsules, powders, pills, powders, fine granules, granules,
Examples include syrups and troches. In addition, there is no problem even if saccharides (sorbitol, lactose, lactose, etc.), inorganic substances such as starch, calcium carbonate, calcium sulfate, etc. commonly used ones such as sesame oil, corn oil, olive oil etc. are added as excipients. In addition, additives such as an emulsifier, a dispersant, a buffer, and an antioxidant can be used for formulation.

[0102]

The present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples. In addition,% is based on mass unless otherwise specified.

Example 1 <Measurement of Hair Growth Effect (Measurement of Hair Growth Effect in Mouse)> The fatty acids and fatty acid monoglycerides shown in Table 1 below are 4
% Corn oil, 0.2% L-ascorbic acid stearic acid ester, and a surfactant were added to a test solution to make 1%, and the mixture was stirred under a nitrogen reducing condition to prepare an emulsion for use in the test. I was there. The control group was a vehicle only.

C3H / HeSle at rest of hair cycle
Using a mouse (7 weeks old), the method of Ogawa et al. (Fragrance Journal, Vol. 17, No. 5, P. 20-2)
9, 1989). The back hair of the mouse was shaved with an electric clipper and an electric shaver.
The test was carried out by freely ingesting each test solution as drinking water from the day after hair removal, and the control group was a vehicle only. Six mice were used for each sample, and the results of the hair regeneration area on the 20th day were expressed as a percentage, and the average value was obtained. The results are shown in Table 1. <Evaluation Criteria> ◎ (excellent): Hair regeneration area of over 70% ○ (Effective): Hair regeneration area of 50 to 70% × (Invalid): Hair regeneration area of less than 50%

[0105]

[Table 1] As is clear from the results shown in Table 1, hair regrowth was significantly increased in the odd-numbered fatty acids and their derivatives. In particular, a high effect was observed for odd-numbered fatty acid monoglycerides having a chain length of 9 to 19.

Example 2 <Measurement of Hair Growth Effect (Measurement of Hair Growth Effect in Mouse)> By the same method as in Example 1, the test samples shown in Table 2 below were dispersed in drinking water at a concentration of 1%. Then, a hair-growth test was conducted with free intake. The emulsion to which the test sample was not added was used for the control group. Six mice were used for each sample, and the results of the hair regeneration area on the 20th day were expressed as a percentage, and the average value was obtained. The results are shown in Table 2.

[0107]

[Table 2] From the results shown in Table 2, the hair-growing effect was observed with all of α, β, γ, δ, and palm oil tocotrienols, and in particular, a high effect was observed with palm oil tocotrienols.

Example 3 <Measurement of Hair-Growing Effect (Measurement of Hair-Growing Effect in Mouse)> Roots and above-ground parts of dried Choleus forskoli, Muirapuama, Anemopae belonging to the genus Ptychopetalum, Anemopae (Anemopae)
Catauba, Solanau belonging to the genus Gma
m) Jurbeba belonging to the genus, Barbatimon Verdadeiro, Dalber belonging to the genus Styphnodendron
gia) Veronica, steril thistle (C
Aniva (Anna) belonging to the genus
Casca preciosa belonging to the genus (iba), mint (M
entha) orteran pimenta belonging to the genus, Cordon de de genus belonging to the genus Lembas (Leucas)
Frade, Calapiscio de Agulla, Picon, Potormofe (P) belonging to the genus Bidens
Kaaperba belonging to the genus Othomorphe, Maria belonging to the genus Eupatorium
Blator, camberer, Aiyapana, Brosimum (B
Muirapiranga belonging to the genus rosimum, Guaco belonging to the genus Mikunia, Sipo Caberudo, Scriju, Andylova belonging to the genus Carapa, Kumarou, Kumarulana and Simarba belonging to the genus Dipteryx
malpauba, fig (Fic)
Phys.
amapu, which belongs to the genus alis)
Erva Toston belonging to the genus erhavia, Mutamba belonging to the genus Guazuma, and Joazeiro belonging to the genus Zyzypus are used as extraction raw materials, and the following nourishment is carried out using an extract obtained by using 10 times each of ethanol. A hair test was performed.

[0109] In addition, Monostrom
a) Human Exa belonging to the genus, Anahusa belonging to the genus Ulva, Ulva perforatum, Sea lettuce, Latrodectus japonicum belonging to the genus Caetomomorpha,
Honeymoths belonging to the genus Bryopsis, cucumber vines belonging to the genus Caulerpa, mills belonging to the genus Codium, and matsumo
pus) belonging to the genus Pinus, Okinawa
Osmophone belonging to the genus Ossiphon, mozuku belonging to the genus Nemacytis, Lessonia nigresense belonging to the genus Lessonia, derbilia antarctica belonging to the genus Durvillea, Ainu sea turtle (Ala)
Aria wakame, Ascophyllum (A) belonging to the genus ria)
Ascophyllum nodosum, belonging to the genus Scophyllum, and arame belonging to the genus Eisenia,
Shio Midoro belonging to the genus Ectocarpus, Honda Walla belonging to the genus Sargassum, Fushijimoku, Macrocystis (Macr)
macrocystis belonging to the genus Ocystis, caninote belonging to the genus Amphiroa, helitricaninote belonging to the genus Marginisporum, Asakusanori, Susabinori, and Cerami belonging to the genus Porphyra
um) belonging to the genus Amixa, squid, ceramium rubrum, red bud (Rhodoglossu)
m) belonging to the genus Red-legged scabbard, Iridia (Ir
Idiadia cordata, Iridia cornucopiae, Iridia edulis, Iridia flacida, Gracilari
a) which belongs to a)
Eriocladia genus Otter, Pterocladia tenuis, Yukiiri (Acanthopel)
tis) and Yukiiri and Bone (Bonne)
maisonia, Rhododendron (Rho)
dymenia) genus Dulcus, Japanese buckthorn (C
allophyllis) genus Calophilis barriegata, Nezashinotokamonoki, Hosobanotosakanoki, hirohanotosakanoki, quinuhadha, hirakusa (B
Eckerella) genus Hirakusa, Funori (G
Fukurofunori belonging to the genus Loiopeltis, Maxa belonging to the genus Gelidium, and Onyx,
Oobusa, Geridium latifolium, Halymenia genus Tsurugi, Isonohana, Oenothera, Marbagsa, Oumkadenori, Harimenia Formosa, Saimi (Ahnfeltia)
It is a genus belonging to the genus Campylaep.
Hori)
a) Macri belonging to the genus is used as an extraction raw material for 10
The following hair-growth test was carried out using a product obtained by evaporating the extract obtained by using twice the amount of water to dryness, dry powder of Coleus root, and forskolin purchased as a reagent.

<Hair Rearing Test> The test substance was dispersed in drinking water in the same manner as in Example 1 to give 0.01%, and was allowed to freely ingest. The emulsion to which the test sample was not added was used for the control group. Six mice were used for each sample, and the results of the hair regeneration area on the 20th day were expressed as a percentage, and the average value was obtained. The results are shown in Tables 3 and 4.

[0111]

[Table 3]

[0112]

[Table 4]

From the results shown in Tables 3 and 4, hair-growth effects were observed with these test substances.
Forskolin, Yanbaru Tsuruhakka (Leucas)
Cordon de Frade extract belonging to the genus, Campanula extract belonging to the genus Eupatorium, Muirapiranga extract belonging to the genus Brosimum, Kamapu extract belonging to the genus Physalis, to the genus Ulva Extracts belonging to the genus Angustifolium, the extracts of Ooasa, the lettuce extracts, the extracts of Okinawa mozuku, which belongs to the genus Cladosiphon, and the mochi (Nemacyst)
Isuzu extract belonging to the genus Durvia (Durv
illrea) derbyria antarctica extract, Ainu sea turtle (Alaria) genus Ainu wakame extract, Ascophyllum (Ascophyll)
um) Ascophyllum nodosum extract, Kaninote extract belonging to the genus Amphiroa, Asakusanori extract belonging to the genus Porphyra, Susabinori extract, Japanese horse chestnut (Cal)
Lophyllis) belonging to the genus Lactobacillus variegata extract, Nezasinotosakanoki extract, Hirohnotosakanoki extract, Quinunada extract, Funori (Glo
Fukurofunori extract belonging to the genus Iopeltis, Fuligusa extract belonging to the genus Halymenia, Marbagsa extract, Ahminti
a) An evening primrose extract belonging to the genus Macri (Digen)
A high effect was confirmed for the mackerel extract belonging to the ea) genus,
In particular, a high effect was confirmed by the extract of Coleus root, Forskolin, and the extract of Derbyria antarctica belonging to the genus Durvillea.

As is clear from the results shown in Tables 1 to 4, the odd-chain fatty acid or its derivative according to the present invention, the plant and its extract, the seaweed and its extract, and the tocotrienol were orally administered to A significantly excellent hair growth promoting effect was recognized.

[Examples 4 to 52 and Comparative Example 1] Use effect test The effect of using the hair-growing agent of the present invention as a food or drink was examined. Pentadecanoic acid glyceride, Coleus root extract (ethanol extract from dry root),
In order to determine the hair-growing effect of palm oil tocotrienol, cookies having the compositions shown in Tables 5 to 10 were baked. Table 5
The cookies were tested by having 10 panelists (25 to 50 years old) in each group who complained of thinning hair and alopecia eat two pieces at the time of the meal in the morning and evening. After the use test for 3 months and 6 months, the hair-growth effect was judged according to the following criteria. The results are shown in Table 11. In addition, as Comparative Example 1, a cookie not containing these test components was used. The test was conducted in a double blind manner. The results are shown in Table 11. The extract described below was extracted by the extraction method described in Example 3.

<Evaluation criteria> "Effective": A lot of downy hairs were generated. "Slightly effective": Some downy hair was generated. "Invalid": No change from before use. <Comprehensive judgment> A: Excellent effect is recognized. B: The effect is high. C: The effect is recognized. E: No effect.

[0117]

[Table 5] Cookie composition (1)

[0118]

[Table 6] Cookie composition (2)

[0119]

[Table 7] Cookie composition (3)

[0120]

[Table 8] Cookie composition (4)

[0121]

[Table 9] Cookie composition (5)

[0122]

[Table 10] Cookie composition (6)

[0123]

[Table 11]

[Examples 53 to 76] Tablets The ingredients shown in Tables 12 to 14 below were mixed and tableted by a direct powder compression method to give tablets.

[0125]

[Table 12] Tablet composition (1)

[0126]

[Table 13] Tablet composition (2)

[0127]

[Table 14] Tablet composition (3)

[Examples 77 to 103] Using margarine pentadecanoic acid monoglyceride and palm oil tocotrienol, the oil phase portion and the water phase portion prepared by completely mixing and dissolving each in the formulations shown in Tables 15 to 17 below were combined. Then, the mixture was uniformly dispersed, and this was rapidly mixed with a vortexer to produce margarine.

[0129]

[Table 15] Margarine composition (1)

[0130]

[Table 16] Margarine composition (2)

[0131]

[Table 17] Margarine composition (3)

[Examples 104 to 130] Coffee Jelly <1> The formulations shown in Tables 18 to 20 were dispersed in 250 ml of boiling water,
The dissolved product was refrigerated to obtain coffee jelly.

[0133]

[Table 18] Coffee jelly composition (1)

[0134]

[Table 19] Coffee jelly composition (2)

[0135]

[Table 20] Coffee jelly composition (3)

[Examples 131 to 139] Coffee jelly <2> To Examples 96 to 104, a saw palm extract from substances having a 5α-reductase inhibitory action was added, and the composition shown in Table 21 below was obtained. Mix and disperse in 250 mL of boiling water,
The dissolved product was refrigerated to obtain coffee jelly.

[0137]

[Table 21] Coffee jelly composition (4)

[Examples 140 to 166] Mayonnaise pentadecanoic acid monoglyceride, α-tocotrienol, and rosemary extract, purple root extract, and finasteride were selected from substances having an inhibitory effect on 5α-reductase, and the results are shown in Table 22 below. Mayonnaise having the composition shown in 23 and 24 was prepared. Specifically, each component except the egg yolk in the aqueous phase was thoroughly mixed, and then the egg yolk was dispersed. Next, an oil phase in which corn salad oil and locust bean gum were thoroughly mixed with a homomixer was gradually added at 5 mL / sec.
The mixture was emulsified at 0 rpm and sterilized at 80 ° C. for 1 minute to obtain mayonnaise.

[0139]

[Table 22] Mayonnaise composition (1)

[0140]

[Table 23] Mayonnaise composition (2)

[0141]

[Table 24] Mayonnaise composition (3)

[Examples 167 to 184] From the soft drink water Choleus root extract and the substances having a 5α-reductase inhibitory action, clove oil, Coomassae extract and Scutellaria barbae extract were selected from Tables 25 and 26. Based on the prescription, a soft drink was produced by a conventional method.

[0143]

[Table 25] Soft drinks (1)

[0144]

[Table 26] Soft drinks (2)

In all of the blended products of Examples 11 to 184, the same high hair growth promoting effect as in Examples 1 to 10 was recognized.

[0146]

According to the present invention, (A) a fatty acid having an odd carbon chain length and its derivative, (B) an alcohol having an odd carbon chain length and its derivative,
(C) Plants such as Choleus and its extracts, (D) Seaweeds such as Human Exa and their extracts, and one or more selected from tocotrienols are contained as active ingredients, so that they are excellent in oral intake. It was possible to provide an oral hair-growth agent having a hair growth-promoting effect and foods and drinks containing the hair-growth agent.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A23L 2/38 A23L 2/38 Z 4C206 2/52 A61K 31/23 A61K 31/23 31/353 31/353 35/78 C 35/78 D J QR T 35/80 Z 35/80 47/10 47/10 A61P 17/14 A61P 17/14 A23L 2/00 F (72) Inventor Daisaburo Yokoyama Sumida-ku, Tokyo Office 1-3-7 Lion Co., Ltd. (72) Inventor Atsushi Naito Head Office Sumida-ku, Tokyo 1-3-7 Lion Office Co., Ltd. (72) Inventor Hidehiko Ishimaru 1 Sumida-ku, Tokyo 1 3rd-7th in Lion Co., Ltd. (72) Inventor Tatsuyuki Midori 1-3-7 Main Office, Sumida-ku, Tokyo F-Term (3) in Lion Corporation (reference) 4B017 LC03 LG15 LG18 LK07 LK09 4B018 MD08 MD09 MD10 MD61 MD67 ME14 4C076 AA17 BB01 CC18 DD37E DD38E FF15 4C086 AA01 AA02 BA08 MA03 MA05 MA08 NA14 ZA92 4C088 AA12 AA13 AA14 AA15 AB12 AB23 AB26 AB34 AB38 AB48 AB59 BA08 BA09 BA10 CA05 DB72 MA03 MA02 NA72 ZA92 A47 ZA92 A47 ZA92 A47 ZA92 A47 ZA92 4A206

Claims (3)

[Claims] 1. An oral hair nourishing agent having a hair growth promoting action by oral ingestion, containing one or more selected from the following components (A) and (E) as active ingredients. (A) Fatty acid having an odd carbon chain length and its derivative (B) Alcohol having an odd carbon chain length and its derivative (C) Genus Coleus, Ptychopetalum genus, Anemopaegma (Anemopaegma) genus, Solanau
m) genus, Stryphnodendon
dron) genus, Dalbergia
Genus, Cynara, Aniva (A
genus niba, mentha Mentha, genus Yanbarutsu genus (Leucas), genus Sedge (Bide)
ns), Pothomorphe
Genus, genus Eupatorium, genus Brosimun, genus Mikani
a) genus, Carapa genus, Tonka bean (Di
pteryx), Simarouba
Genus, genus Ficus, physalis (Physa)
lis) genus, Boerhavia
Genus, Guazuma and Date (Ziz)
plant selected from the genus yphus and its extract (D) genus Humanstroma, genus Ulva, genus Caetomomorpha
Genus, genus Bryopsis, cucumber (Cau)
Lerpa, Mill (Codium), Matsumo (A)
genus nalipus, Okinawa mozuku (Cladosi)
genus, Nemacystis genus, Lessonia genus, Durville (Dur)
Villea), Ainu seaweed (Alaria) genus,
The genus Ascophyllum, the genus Eisenia, the Ectocarp
genus us, genus Sargassum, genus Macrocystis, genus Amphiroa, genus Helitricaninote (Marg)
genus inisporum, Porphyr
a) genus, Ceramium genus, Rhodoglossum genus, Iridea genus, Gracilar genus
ia), genus Pterocladia, genus Acanthopeltis, genus Bonemaisonia, Rhody.
genus C. genus, Calliphyllum (Callophyll)
genus is, genus Becherella, genus Gloiopeltis, genus Gelid
ium genus, Halymenia genus, Ahnfeltia genus, Camphor
seaweed selected from the genus laephora and the genus Digenea and its extract (E) tocotrienol 2. The oral hair-growth agent according to claim 1, further comprising (F) a substance having an inhibitory action on 5α-reductase and / or (G) a cell activator. 3. A food or drink comprising the oral hair-growth agent according to claim 1 or 2.