JP2001278750A - New hair-growing agent - Google Patents
New hair-growing agentInfo
- Publication number
- JP2001278750A JP2001278750A JP2000090917A JP2000090917A JP2001278750A JP 2001278750 A JP2001278750 A JP 2001278750A JP 2000090917 A JP2000090917 A JP 2000090917A JP 2000090917 A JP2000090917 A JP 2000090917A JP 2001278750 A JP2001278750 A JP 2001278750A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- hair growth
- growing agent
- present
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、新規な育毛剤に関
する。TECHNICAL FIELD The present invention relates to a novel hair restorer.
【従来の技術】一般に、育毛剤、発毛剤、発毛促進剤、
養毛剤等と称される育毛剤は、比較的長期間にわたり連
用されることから、優れた育毛、発毛、発毛促進、養毛
効果を呈するとともに、安全性の高いことが要求され
る。近年、スフィンゴ脂質の機能が徐々に解明され、細
胞間相互作用や細胞間認識への関与、受容体や受容体の
構成成分としての役割に加えて、シグナル伝達やその制
御においても重要な役割を担っていることが明らかにな
ってきている。しかしながら、スフィンゴ脂質が毛の生
長に関与しているという報告はない。2. Description of the Related Art In general, hair restorers, hair growth agents, hair growth promoters,
Since a hair restorer called a hair restorer or the like is used continuously for a relatively long period of time, it is required to exhibit excellent hair growth, hair growth, promotion of hair growth, hair growth effect, and high safety. In recent years, the functions of sphingolipids have been gradually elucidated, and in addition to their involvement in cell-cell interactions and cell-cell recognition, their role as receptors and components of receptors, they also play important roles in signal transduction and its regulation. It is becoming clear that they are responsible. However, there is no report that sphingolipids are involved in hair growth.
【０００２】[0002]
【発明が解決しようとする課題】本発明の目的は、新規
な育毛剤を提供するものである。An object of the present invention is to provide a new hair restorer.
【０００３】[0003]
【課題を解決するための手段】本発明者らは、スフィン
ゴ脂質に着目し、その新規な用途につき鋭意検討した結
果、このものが育毛成分として有用であることを見出
し、本発明を完成した。すなわち、本発明は、（１）ス
フィンゴ脂質を含有する育毛剤、（２）スフィンゴリン
脂質を含有する育毛剤、（３）スフィンゴミエリン、ス
フィンゴシルフォスフォリルコリンおよびスフィンゴシ
ン−１−リン酸から選ばれる１種または２種以上を含有
する育毛剤、（４）スフィンゴ脂質を育毛成分として含
有する毛髪用組成物、（５）剤形が外用剤である、スフ
ィンゴ脂質を育毛成分として含有する毛髪用組成物に関
するものである。Means for Solving the Problems The present inventors have paid attention to sphingolipids and have intensively studied a novel use thereof. As a result, they have found that the sphingolipids are useful as a hair-growth component and completed the present invention. That is, the present invention is selected from (1) a hair restorer containing sphingolipids, (2) a hair restorer containing sphingolipids, (3) sphingomyelin, sphingosylphosphorylcholine and sphingosine-1-phosphate. A hair restorer containing one or more kinds, (4) a hair composition containing sphingolipids as a hair restorer, and (5) a hair composition containing sphingolipids as a hair restorer whose dosage form is an external preparation. It is about things.
【０００４】[0004]
【発明の実施の形態】以下に、本発明について説明す
る。本発明における育毛剤とは、育毛作用、発毛作用、
発毛促進作用、養毛作用等のいずれか、又はそれらの２
以上の作用を有するものを意味しており、いかなる意味
においても限定して解釈してはならない。DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below. The hair restorer in the present invention, hair growth action, hair growth action,
Any of hair growth promoting action, hair nourishing action, etc. or their 2
It means those having the above actions, and should not be construed as limiting in any sense.
【０００５】本発明に用いるスフィンゴ脂質は、動物か
ら細菌類に至る生体の生体膜に微量に存在する生体膜の
構成成分である。スフィンゴ脂質は、セラミド、セレブ
ロシド、ガングリオシド、スルファチド、スフィンゴミ
エリンのような長鎖塩基（スフィンゴシン）を含む総称
で、主としてスフィンゴ糖脂質とスフィンゴリン脂質か
ら成る。スフィンゴ糖脂質の代表的なものとして、セレ
ブロシド、ガングリオシド、スルファチドなどを挙げる
ことができる。スフィンゴリン脂質の代表的なものとし
て、スフィンゴミエリン、スフィンゴシルフォスフォリ
ルコリン（リゾスフィンゴミエリン）、スフィンゴシン
−１−リン酸などを挙げることができる。スフィンゴ脂
質は、生体内成分であるが故に、このものを皮膚等に塗
布しても、皮膚刺激などの副作用を示すものではない。[0005] The sphingolipid used in the present invention is a component of a biological membrane present in a trace amount in a biological membrane of a living body ranging from animals to bacteria. Sphingolipid is a generic term including long-chain bases (sphingosine) such as ceramide, cerebroside, ganglioside, sulfatide, and sphingomyelin, and is mainly composed of glycosphingolipids and sphingolipids. Representative examples of glycosphingolipids include cerebroside, ganglioside, sulfatide and the like. Typical sphingolipids include sphingomyelin, sphingosylphosphorylcholine (lysosphingomyelin), sphingosine-1-phosphate, and the like. Since sphingolipids are in-vivo components, they do not show any side effects such as skin irritation when applied to skin or the like.
【０００６】本発明に用いるスフィンゴ脂質は、動植物
等の組織から抽出・単離、あるいは化学合成により、入
手することが可能である。また本発明においては、スフ
ィンゴ脂質を含む動植物等の適当な組織からの抽出分画
等も育毛成分として利用することが可能である。The sphingolipid used in the present invention can be obtained by extraction and isolation from tissues of animals and plants, or by chemical synthesis. Further, in the present invention, an extract fraction from an appropriate tissue such as animals and plants containing sphingolipids can also be used as a hair growth component.
【０００７】本発明においては、スフィンゴ脂質のう
ち、スフィンゴリン脂質がより好ましく、スフィンゴミ
エリン、スフィンゴシルフォスフォリルコリンおよびス
フィンゴシン−１−リン酸が特に好ましい育毛成分であ
り、これらは単独でも２種以上を組み合せてもよい。In the present invention, among sphingolipids, sphingolipids are more preferred, and sphingomyelin, sphingosylphosphorylcholine and sphingosine-1-phosphate are particularly preferred hair-growth components. May be combined.
【０００８】本発明の育毛剤および毛髪用組成物は、経
口または非経口的に投与することができるが、非経口的
に、直接頭皮に投与可能な製剤が好ましく、このような
製剤の剤形として外用剤を挙げることができる。具体的
には、経口投与製剤の剤形としては、錠剤、散剤、カプ
セル剤、顆粒剤、内服液剤等を挙げることができ、非経
口投与製剤の剤形としては、ローション剤、エアゾール
剤等の外用剤、注射剤等を挙げることができる。また、
シャンプー、リンス、コンディショナー、ヘアトニッ
ク、ヘアクリーム、ヘアリキッド等に配合してもよい。
本発明においては、外用剤が剤形として好ましい。The hair restorer and the hair composition of the present invention can be administered orally or parenterally, but a preparation which can be administered parenterally and directly to the scalp is preferred. Can be an external preparation. Specifically, examples of the dosage form of the oral administration preparation include tablets, powders, capsules, granules, and oral liquids. Examples of the dosage form of the parenteral administration preparation include lotions, aerosols, and the like. External preparations, injections and the like can be mentioned. Also,
You may mix | blend with a shampoo, a rinse, a conditioner, a hair tonic, a hair cream, a hair liquid, etc.
In the present invention, an external preparation is preferable as a dosage form.
【０００９】製剤化は、公知の製剤技術により行うこと
ができ、製剤中には、適当な製剤添加物を加えることが
可能である。製剤添加物としては、賦形剤、懸濁化剤、
乳化剤、保存剤、保湿剤、香料等を挙げることができ
る。なお、製剤中に加える製剤添加物は、製剤の投与量
において、人体等の生体にとって無害であり、また製剤
中の有効成分による効果を妨げないことが必要である。[0009] Formulation can be carried out by known formulation techniques, and it is possible to add appropriate formulation additives into the formulation. Excipients, suspending agents,
Emulsifiers, preservatives, humectants, perfumes and the like can be mentioned. It should be noted that the formulation additive added to the formulation must be harmless to the living body such as the human body at the dosage of the formulation and must not hinder the effect of the active ingredient in the formulation.
【００１０】製剤化された本発明の育毛剤、すなわち本
発明の毛髪用組成物は、使用者の性別、年齢、症状等に
応じて、適当量を毛髪が減少している部位および／また
は毛髪の発生部位に塗布または噴霧等すればよい。製剤
中のスフィンゴ脂質の配合量としては、適宜、使用者の
性別、年齢、症状、使用目的等を考慮して検討すればよ
いが、０．００００１〜５重量％の範囲内が好ましく、
０．０１〜１重量％の範囲内とするのがより好ましい。[0010] The formulated hair restorer of the present invention, ie, the hair composition of the present invention, is used in an appropriate amount depending on the sex, age, symptoms, etc. of the user, in an area where the hair is reduced and / or in the hair. It may be applied or sprayed to the site where the occurrence of. The amount of sphingolipid in the preparation may be appropriately determined in consideration of the user's sex, age, symptoms, intended use, etc., but is preferably in the range of 0.00001 to 5% by weight,
More preferably, it is in the range of 0.01 to 1% by weight.
【００１１】さらに、本発明の育毛剤および毛髪用組成
物には、すでに育毛、発毛、発毛促進、養毛効果を有す
る公知の成分を加えてもよい。これらの成分としては、
例えば、呉茱萸、五味子、牡丹皮、木瓜、白蘚皮、五加
皮、半夏、大黄、牛膝、枸杞子、茯苓、干姜、陳皮、甘
草、百部、地骨皮、柴胡、天麻、白芍、荊芥、桂枝、苦
参、鳴血藤、骨砕捕、花椒、黄連、人参、黒豆、何首
烏、朝鮮人参、竹節人参、補骨脂、当帰、鶏血藤、丹
参、紅花、桃仁、防風、茜草根、拳参、山茱萸、半支
蓮、楊梅皮、側柏葉および当薬等の生薬並びにこれら生
薬の抽出物（チンキ、エキスなど）、さらには塩化カル
プロニウム、パントテニールエチルエーテル、ミノキシ
ジール、ビタミンＥおよびその誘導体、セファランチ
ン、ニコチン酸ベンジル、ニコチン酸アミド、ビオチ
ン、Ｄ−パントテニルアルコール、イソプロピルメチル
フェノール、ヒノキチオール、ｌ−メントール、溶性シ
スチン、オクトピロックス、塩化ベンザルコニウム、ピ
リドキシンおよびその誘導体、サリチル酸、塩酸ジフェ
ンヒドラミン、グリチルリチン酸、グリチルレチン酸、
ペンタデカン酸グリセリド等を挙げることができる。こ
れらの成分は、本発明の育毛剤および毛髪用組成物に単
独で加えてもよく、また２種以上を組み合わせて加えて
もよい。Further, the hair restorer and the composition for hair of the present invention may be added with a known component having a hair growth, hair growth, hair growth promotion and hair growth effect. These components include:
For example, goshuyu, gomiko, peony skin, cucumber, white moss bark, gokahi, midsummer, rhubarb, beef knee, guikoko, bukuryo, dried ginger, cinnabar, licorice, one hundred parts, ground skin, saiko, Tenma, Shiakusha, Ikugaku, Keishi, Bitter ginseng, Naruto blood wisteria, Bone crush, Pepper, Oren, Ginseng, Black bean, Hebeko, Ginseng, Bamboo ginseng, Bone fat, Toki, Chicken wisteria, Dansin , Safflower, peach blossoms, windbreak, Akane grass root, feng ginseng, sanshuyu, hansho, Yangmei skin, side bamboo leaf and herbal medicines and extracts of these herbal medicines (tinctures, extracts, etc.), and carpronium chloride, pantothenil Ethyl ether, minoxydil, vitamin E and its derivatives, cepharanthin, benzyl nicotinate, nicotinamide, biotin, D-pantothenyl alcohol, isopropylmethylphenol, hinokitiol, l-menthol, soluble cystine, octopirox, Of benzalkonium, pyridoxine and its derivatives, salicylic acid, diphenhydramine hydrochloride, glycyrrhizic acid, glycyrrhetinic acid,
Glyceride pentadecanoate and the like can be mentioned. These components may be added alone to the hair restorer and the hair composition of the present invention, or may be added in combination of two or more.
【００１２】本発明の育毛剤および毛髪用組成物は、具
体的には育毛、発毛、発毛促進および／または養毛用に
用いるものである。したがって、本発明の育毛剤および
毛髪用組成物の効能・効果としては、育毛、発毛、薄
毛、毛生促進、発毛促進、脱毛（抜け毛）の予防、病後
・産後の脱毛、養毛、円形脱毛症、発毛不全、粃糠性脱
毛症、脂漏性脱毛症、びまん性脱毛症、若禿（壮年性脱
毛症）および老人禿等を挙げることができる。The hair restorer and the composition for hair of the present invention are specifically used for hair growth, hair growth, promotion of hair growth and / or hair growth. Therefore, the effects and effects of the hair restorer and the hair composition of the present invention include hair growth, hair growth, thinning hair, promotion of hair growth, promotion of hair growth, prevention of hair loss (hair loss), hair loss after disease and postpartum, hair growth, Alopecia areata, hair loss deficiency, pityriasis alopecia, seborrheic alopecia, diffuse alopecia, young baldness (mature alopecia), and elderly baldness can be mentioned.
【００１３】[0013]
【発明の効果】本発明に用いるスフィンゴ脂質は、優れ
た育毛、発毛、発毛促進、養毛効果を示した。また、こ
のものは皮膚刺激等の有害な副作用を示さなかった。し
たがって、スフィンゴ脂質は育毛剤の有効成分として有
用なものである。The sphingolipid used in the present invention has excellent hair growth, hair growth, hair growth promotion and hair growth effects. It did not show any harmful side effects such as skin irritation. Therefore, sphingolipids are useful as an active ingredient of a hair restorer.
【００１４】[0014]
【実施例】以下に実施例を示し、本発明をさらに詳細に
説明するが、本発明はこれらの実施例によりなんら限定
されるものではない。 ［実施例１］ラット毛生長試験 Sprague-Dawley（SD）ラットの２１日齢メスを８匹（４
匹ずつが同腹）用意し肩胛骨間部皮膚を１×２ｃｍ程度
の範囲で刈毛した。スフィンゴシルフォスフォリルコリ
ン（Sphingosyl phosphorylcholine（以下、ＳＰＣと略
する。））を３３％プロピレングリコールと６７％エタ
ノール混液に溶解し、ＳＰＣとして、０Ｍ、２０μＭ、
２００μＭ、２ｍＭの濃度別の溶液を準備した。生後２
１日から６１日間（第2毛周期の休止期）までの４１日
間、それぞれの濃度のＳＰＣ溶液を１日１回、週６回の
ペースで、２匹ずつのラットの刈毛部にそれぞれ５００
μlを塗布した。そして６２日目に肩胛骨間部における
毛髪の生長の様子を写真撮影し、ＳＰＣ塗布による効果
を確認した。その結果、スフィンゴシルフォスフォリル
コリンは皮膚に炎症を起こさず、濃度依存的にラットの
毛の生長を促進した。EXAMPLES The present invention will be described in more detail with reference to the following Examples, which by no means limit the present invention. [Example 1] Rat hair growth test Eighteen 21-day-old female Sprague-Dawley (SD) rats (4
The scapula was cut in a range of about 1 × 2 cm. Sphingosyl phosphorylcholine (hereinafter abbreviated as SPC) is dissolved in a mixture of 33% propylene glycol and 67% ethanol, and as SPC, 0 M, 20 μM,
Solutions having different concentrations of 200 μM and 2 mM were prepared. 2 after birth
For 41 days from 1 day to 61 days (the rest period of the second hair cycle), the SPC solution of each concentration was applied to the shaved area of two rats at a rate of once a day, six times a week, at a rate of 500 g each.
μl was applied. Then, on the 62nd day, a photograph of the state of hair growth in the interscapular region was taken, and the effect of SPC application was confirmed. As a result, sphingosylphosphorylcholine did not cause skin inflammation and promoted rat hair growth in a concentration-dependent manner.
【図１】 スフィンゴシルフォスフォリルコリンを含ま
ない３３％プロピレングリコールと６７％エタノール混
液を塗布したラット（コントロール）の毛髪の生長の様
子を示した写真である。FIG. 1 is a photograph showing hair growth of a rat (control) to which a mixture of 33% propylene glycol and 67% ethanol not containing sphingosylphosphorylcholine was applied.
【図２】 スフィンゴシルフォスフォリルコリン２０μ
Ｍを含む３３％プロピレングリコールと６７％エタノー
ル混液を塗布したラットの毛髪の生長の様子を示した写
真である。FIG. 2 Sphingosylphosphorylcholine 20μ
It is the photograph which showed the mode of hair growth of the rat which apply | coated 33% propylene glycol containing M and 67% ethanol mixed solution.
【図３】 スフィンゴシルフォスフォリルコリン２００
μＭを含む３３％プロピレングリコールと６７％エタノ
ール混液を塗布したラットの毛髪の生長の様子を示した
写真である。FIG. 3 Sphingosylphosphorylcholine 200
It is the photograph which showed the mode of the hair growth of the rat which apply | coated the 33% propylene glycol containing 67 microliters and 67% ethanol.
【図４】 スフィンゴシルフォスフォリルコリン２ｍＭ
を含む３３％プロピレングリコールと６７％エタノール
混液を塗布したラットの毛髪の生長の様子を示した写真
である。FIG. 4 Sphingosylphosphorylcholine 2 mM
1 is a photograph showing the state of hair growth of a rat to which a mixed solution of 33% propylene glycol and 67% ethanol containing is applied.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 三浦 優子 千葉県市川市曽谷５−27−１ Ｆターム(参考） 4C083 AC102 AC122 AD571 AD572 CC37 DD23 EE10 EE22 4C084 AA02 BA47 BA48 NA07 NA14 ZA921 ZA922 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Yuko Miura 5-27-1 Soya, Ichikawa-shi, Chiba F-term (reference) 4C083 AC102 AC122 AD571 AD572 CC37 DD23 EE10 EE22 4C084 AA02 BA47 BA48 NA07 NA14 ZA921 ZA922
Claims (5)
ォスフォリルコリンおよびスフィンゴシン−１−リン酸
から選ばれる１種または２種以上を含有する育毛剤。3. A hair restorer containing one or more selected from sphingomyelin, sphingosylphosphorylcholine and sphingosine-1-phosphate.
る毛髪用組成物。4. A hair composition containing sphingolipids as a hair growth component.
用組成物。5. The hair composition according to claim 4, wherein the dosage form is an external preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000090917A JP2001278750A (en) | 2000-03-29 | 2000-03-29 | New hair-growing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000090917A JP2001278750A (en) | 2000-03-29 | 2000-03-29 | New hair-growing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001278750A true JP2001278750A (en) | 2001-10-10 |
Family
ID=18606448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000090917A Pending JP2001278750A (en) | 2000-03-29 | 2000-03-29 | New hair-growing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001278750A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003160486A (en) * | 2001-09-17 | 2003-06-03 | Lion Corp | Oral hair grower and food/drink containing the same |
| EP1938824A1 (en) * | 2005-09-22 | 2008-07-02 | Snow Brand Milk Products Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| JP2011168589A (en) * | 2003-05-30 | 2011-09-01 | Sanofi-Aventis Deutschland Gmbh | Use of s1p |
| WO2011121093A1 (en) * | 2010-03-31 | 2011-10-06 | Dsm Ip Assets B.V. | Use of organic compounds in hair care |
| JP2011530503A (en) * | 2008-08-06 | 2011-12-22 | ピトス カンパニー リミテッド | Hair loss prevention / treatment or hair growth composition |
| JP2013529209A (en) * | 2010-05-19 | 2013-07-18 | バイオピド、コーポレーション | Composition for preventing hair loss or promoting hair growth |
| JP2016520546A (en) * | 2013-04-04 | 2016-07-14 | ピトス カンパニー リミテッド | Novel phytosphingosine-1-phosphate derivative, method for preparing the same, and composition for preventing, treating or growing hair loss comprising the same |
| WO2018053096A1 (en) * | 2016-09-16 | 2018-03-22 | The Procter & Gamble Company | Method of increasing uptake and washfastness of hair health compounds |
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2000
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| JP2003160486A (en) * | 2001-09-17 | 2003-06-03 | Lion Corp | Oral hair grower and food/drink containing the same |
| JP2011168589A (en) * | 2003-05-30 | 2011-09-01 | Sanofi-Aventis Deutschland Gmbh | Use of s1p |
| AU2006293026B2 (en) * | 2005-09-22 | 2012-08-16 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| EP1938824A4 (en) * | 2005-09-22 | 2009-07-22 | Snow Brand Milk Products Co Ltd | Medicine, food and drink or feed containing sphingomyelin |
| EP1938824A1 (en) * | 2005-09-22 | 2008-07-02 | Snow Brand Milk Products Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| US8486916B2 (en) | 2005-09-22 | 2013-07-16 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| US9186366B2 (en) | 2005-09-22 | 2015-11-17 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| JP2011530503A (en) * | 2008-08-06 | 2011-12-22 | ピトス カンパニー リミテッド | Hair loss prevention / treatment or hair growth composition |
| US8729052B2 (en) | 2008-08-06 | 2014-05-20 | Phytos Co., Ltd. | Composition for the prevention and treatment of alopecia, or for hair growth |
| WO2011121093A1 (en) * | 2010-03-31 | 2011-10-06 | Dsm Ip Assets B.V. | Use of organic compounds in hair care |
| JP2013529209A (en) * | 2010-05-19 | 2013-07-18 | バイオピド、コーポレーション | Composition for preventing hair loss or promoting hair growth |
| JP2016520546A (en) * | 2013-04-04 | 2016-07-14 | ピトス カンパニー リミテッド | Novel phytosphingosine-1-phosphate derivative, method for preparing the same, and composition for preventing, treating or growing hair loss comprising the same |
| WO2018053096A1 (en) * | 2016-09-16 | 2018-03-22 | The Procter & Gamble Company | Method of increasing uptake and washfastness of hair health compounds |
| CN109640934A (en) * | 2016-09-16 | 2019-04-16 | 宝洁公司 | Increase the method for the absorption and washability of hair health compound |
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