JPH10279437A - Hair cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic having an excellent hair falling- preventing effect, an excellent trichogenous effect, and an excellent hair thinning-preventing effect, and excellent in safety by combinedly compounding a blood circulation-stimulating ingredient and a specific amine oxide. SOLUTION: This cosmetic comprises (A) 0.001-5.0 wt.%, preferably 0.01-2.0 wt.%, of a blood circulation-stimulating ingredient, preferably a nicotinic acid compound, a minoxidil compound, a Swertia japonica extract, etc., (B) 0.0001-20.0 wt.%, preferably 0.05-5.0 wt.%, of dimethylamine oxide of the formula, and, if necessary, (C) a pharmaceutically active ingredient, a plant extract, zinc (derivative), lactic acid (alkyl ester), an organic acid compound, a protease- inhibiting agent, an oil, a polyhydric alcohol, a surfactant, a moisture-retaining agent, a perfume, a colorant, ethanol, water, etc. The cosmetic is preferably administered at a daily dose of 0.001-100 mg per kg of a body weight with two to four portions.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention belongs to the technical field of scalp hair cosmetics (hereinafter referred to as hair cosmetics). More specifically, it belongs to the technical field of hair cosmetics having an excellent blood flow promoting action and also being excellent in safety, and the hair cosmetics of the present invention are particularly useful in the fields of pharmaceuticals, quasi-drugs or cosmetics. Used in

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, depending on the scalp condition, a product that can improve the current condition such as a hair loss condition by promoting blood flow at least in the scalp portion has been developed. Various troubles on the scalp
In today's aging society, social stress is increasing, and the demand for hair cosmetics corresponding to the scalp trouble is increasing rapidly. In general, baldness and alopecia of the head, thinning of hair, itching of the scalp, dandruff, etc. are caused by activation of androgens in organs such as sebaceous glands of hair roots, decreased blood flow to hair follicles, excessive secretion of sebum. , Lipid peroxide formation and stress. In addition, when sufficient hair follicles cannot be supplied with nutrients to grow durable and beautiful hair, fine hair and thin hair may be caused. Decreased blood flow to the hair follicles leads to nutritional deficiency and reduced excretion of waste products.

[0003] From such a viewpoint, improvement of at least a decrease in blood flow function in the scalp is an indispensable point in solving troubles in the scalp and hair. Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, female hormones such as estradiol, cepharanthin and the like Are used in the prevention and treatment of baldness, hair loss and hair thinning.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the cosmetic for hair. There is a tendency to have a feeling and redness,
Naturally, the amount was limited.

The problem to be solved by the present invention is to provide a cosmetic for hair which has an excellent blood flow promoting effect and is also excellent in safety.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining the conventionally used blood flow enhancer with a specific amine oxide, it has excellent hair loss prevention effect, hair growth effect, hair thinning prevention effect, and safety. The present inventors have found that a hair cosmetic composition that is excellent in hair quality is provided, and completed the present invention.

That is, the present invention provides a blood flow enhancer and dimethylamine oxide represented by the following formula (I):

Embedded image And a hair cosmetic composition comprising:

It is particularly desirable that the blood flow promoting component is one or more blood flow promoting components selected from the group consisting of nicotinic acids, minoxidil and assembly extracts. The effect of can be exhibited favorably.

[0009]

Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exhibits a desired effect by being combined with a blood flow promoting component and the above-mentioned dimethyl oxide (I) in combination. The blood flow-promoting component that can be incorporated into the hair cosmetic composition of the present invention, by applying it on the skin, promotes the blood flow of the human body, and as long as there is no safety problem as a component of the external preparation. However, the present invention is not particularly limited, and its action mechanism should not be questioned.

Specifically, nicotinic acid and its derivatives (this is defined as nicotinic acids in the present application),
Minoxidil and its derivatives and analogs thereof (this is defined as minoxidil in the present application), assembly extract, cepharanthin, vitamin Es, γ-oryzanol, alkoxycarbonylpyridine N-oxide,
Those usually compounded as a blood flow promoting ingredient in hair cosmetics such as capronium chloride, acetylcholine and derivatives thereof can be appropriately selected. In addition, these blood flow promoting components can be used alone in the cosmetic for hair of the present invention, but they can also be used in combination of two or more.

Among these blood flow promoting components, it is particularly preferable to select nicotinic acids, minoxidil and / or assembly extracts and blend them into the cosmetic for hair of the present invention.

Examples of the nicotinic acid derivative include benzyl nicotinate, tocopherol nicotinate, β-butoxy nicotinate, nicotinamide and the like.

Of these nicotinic acid derivatives, nicotinic acid benzyl ester, nicotinic amide and the like are currently commercially available. Other nicotinic acid derivatives can be produced by a generally known method.

[0014] Minoxidil has a peripheral vasodilatory effect and has been used for the treatment of intractable hypertension. However, since hirsutism was recognized as a side effect thereof, it has been used as a topical external preparation. (US Patent No. 4)
139,819 and 4,596,812), the chemical name of which is 6- (1-pimelidinyl) -2,4-pyrimidineamine-3-oxide.

Examples of the minoxidil derivative include salts of the minoxidil, and examples of the minoxidil analogs include conjugates of minoxidil. These minoxidils are currently commercially available, and can be usually produced by a known method.

The extract of swallowtail is an extract containing the bitter glycoside of swertia japonica Makino (the main component is swertiamarin). In the present invention, the extract of swertiamarin is also an extract of swertiamarin. The blood flow promoting agent is said to promote blood flow by expanding the capillaries of the skin, and is commercially available.

The amount of the blood flow promoting component in the cosmetic for hair of the present invention is 0.000 to the total amount of the cosmetic for hair.
It is 1% by weight or more and 5.0% by weight or less, preferably 0.01% by weight or more and 2.0% by weight or less.

If the amount is less than 0.001% by weight based on the total weight of the hair cosmetic composition, a sufficient blood flow-promoting effect is not exhibited, which is not preferable. If the amount exceeds 5.0% by weight, skin irritation and the like may occur. This may cause problems from the aspect of safety.

The above-mentioned dimethylamine oxide (I), which is incorporated into the hair cosmetic composition of the present invention together with the above-mentioned blood flow promoting component.
Can be produced according to a known amine oxide production method. If an example is shown, it can be manufactured generally according to the following steps.

Embedded image Usually, the dimethylamine oxide (I) thus produced is incorporated into the cosmetic for hair of the present invention through a purification step by a generally known purification method such as a recrystallization method.

The amount of dimethylamine oxide (I) in the cosmetic for hair of the present invention is 0.0001% by weight or more and 20.0% by weight or less based on the total amount of the cosmetic for hair. It is preferably from 05% by weight to 5.0% by weight.

When the amount is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient blood flow promoting effect cannot be exhibited, which is not preferable. It is not preferable from the viewpoints of, for example, the preparation and skin irritation.

By combining the above-mentioned blood flow-promoting component and the above-mentioned dimethylamine oxide (I) in combination as described above, the present invention has a superior blood flow-promoting effect and is also excellent in safety. Fees are provided. Incidentally, in the hair cosmetic of the present invention, the medicinal component usually blended in the hair cosmetic, for the purpose of exerting the general effect of the medicinal component, the intended effect of the present invention Can be blended as long as is not impaired.

For example, amino acids such as serine, methionine and arginine can be incorporated into the cosmetic for hair of the present invention.

In addition, plant extracts, such as Altea extract, yoquinin extract, and the like, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tangsin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.

Also, zinc or a derivative thereof; lactic acid or an alkyl ester thereof; organic acids such as citric acid;
Protease inhibitors such as tranexamic acid; olive oil,
Oils such as squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, Dyes, ethanol, water, and the like can be appropriately blended within a range that does not impair the intended effect of the present invention.

The form of the cosmetic for hair of the present invention is not particularly limited as long as it can be applied to the outer skin such as liquid, emulsion, ointment and the like. Of the present invention can be prepared. Further, the cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The cosmetic for hair of the present invention can be used for at least a purpose that can be solved to promote blood flow of the scalp, for example, treatment or prevention of hair loss, dandruff, itching, etc.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. In addition, the purpose shown here is an example,
The diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0029]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, tests for examining the hair-growing effect of these embodiments will be described.

1. Blood flow test by laser Doppler method
Experience ALF-2100 (manufactured by Advance Co., Ltd.) laser Doppler method using, i.e. applying a laser to the skin, the deviation of the reflected light (Doppler effect) before and after the test article coated by a method of measuring changes in blood flow using a The change in blood flow was measured. That is, in the following Examples 1 to 10 and Comparative Examples 1 to 5, 1 ml of each sample was applied to a 2 cm × 2 cm square inside the forearm using a panel of 6 persons in each group. Sample application 3
After 0 minute, the blood flow was measured again, and the blood flow promoting effect was evaluated based on the degree of the change.

Each measurement was carried out five times for each panel, and the results were indicated as follows based on the average value of the six persons. +++: The blood flow increased three times or more, and an extremely remarkable effect was observed. ++: The blood flow increased twice or more, and a remarkable effect was observed. +: The blood flow increased 1.5 times or more, and a considerable effect was recognized. ±: The blood flow increased by 1.0 to 1.5 times, and a slight effect was observed. -: No increase in blood flow was observed, and no effect was observed.

2. Hair growth test The hair growth test for the samples of Examples 1 to 10 and Comparative Examples 1 to 5 described below was performed using C3H / HeNC in the telogen of the hair cycle.
Using a mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiation,
Edited by M. Seiji and IABernstein, pp. 159-170, 19
1982, published by The University of Tokyo).

That is, a group of 10 mice was uncoated, divided into groups of Examples 1 to 10 and Comparative Examples 1 to 5, the back of the mouse was shaved with a clipper and a shaver, and each sample was collected for 1 day. One time, 0.1 ml was applied. The hair growth effect of each sample was determined by calculating the area ratio of the hair growth part on the back of the mouse after 30 days (the area of the hair growth part / the area of the shaved part × 100 =
Hair growth rate).

Examples 1 to 10, Comparative Examples 1 to 5 The blood flow promoting lotions of the components shown in Table 1 (Examples 1 to 10) and Table 2 (Comparative Examples 1 to 5) will be described later. It was prepared according to the manufacturing method, and the above blood flow test and hair growth test were performed. The results are also shown in Tables 1 and 2.

[0035]

[Table 1]

[0036]

[Table 2]

<Production Method> A drug (oil-soluble), glycerin, hydrogenated castor oil EO (20 mol) and a flavor are dissolved in 95% ethanol, and then lactic acid, sodium lactate,
The dye and drug (water-soluble) were added and dissolved. This aqueous phase was added to the alcohol phase and stirred to obtain a transparent liquid lotion.

From these results, it is found that the blood flow promoting lotion of the example in which the blood flow promoting component of any of nicotinamide, minoxidil or assembly extract and dimethylamine oxide (I) are blended, uses the blood flow rate after use. Although the blood flow promoting effect and the hair growth effect to increase were remarkably recognized, the hair growth lotion of the comparative example containing only one of these blood flow promoting components and dimethylamine oxide (I) was not affected by these components. When a large amount of was added, both the effect of increasing blood flow and the effect of growing hair were significantly inferior to the results of the above examples.

That is, in the hair cosmetic composition of the present invention in which the above blood flow promoting component and dimethylamine oxide (I) are combined in combination, it is apparent that a synergistic increase in blood flow and a hair growth effect are remarkably observed. Became. This means that even with a small amount of the active ingredient, it is possible to obtain a desired blood flow promoting effect in the hair cosmetic of the present invention,
This indicates that it became possible to prevent an unpleasant irritant feeling and redness of the application part and its peripheral part caused by blending a large amount of the blood flow promoting component.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 11] Medicinal tonic Compounding amount (% by weight) 95% ethanol 60.0 Dimethylamine oxide (I) 8.0 Nicotinic acid β-butoxyethyl ester 0.03 Tocopherol acetate 1.0 Propylene glycol 3.0 Succinic acid Appropriate amount Perfume and pigment Appropriate amount Polyoxyethylene hydrogenated castor oil 5 mol adduct 1.5 Purified water balance

<Production method> In 95% ethanol, a drug (oil-soluble), propylene glycol, a polyoxyethylene hydrogenated castor oil 5 mol adduct and a fragrance are dissolved, and then succinic acid, a dye and a drug (water-soluble) are dissolved in purified water. Was dissolved after the addition. After adding this aqueous phase to the alcohol phase, stirring,
A clear liquid lotion was obtained.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a considerable effect was recognized in the blood flow test, and an 85% effect was recognized in the hair growth test.

Example 12 Hair Nourishing Lotion Compounding amount (% by weight) 95% ethanol 70.0 Dimethylamine oxide (I) 4.0 Minoxidil 1.0 Cepharanthin 0.5 Pepper tincture 0.5 Sorbitol 10.0 Phosphorus Acid 0.1 Sodium phosphate 0.2 Perfume and pigment Suitable amount Sodium lauryl sulfate 2.0 Purified water balance

<Production method> A drug (oil-soluble), pepper tincture and perfume are dissolved in 95% ethanol, and then phosphoric acid, sodium phosphate, sorbitol, sodium lauryl sulfate, a dye and a drug (water-soluble) are dissolved in purified water. After the addition,
Dissolved. This aqueous phase was added to the alcohol phase and stirred to obtain a transparent liquid lotion.

When the above test was carried out on the cosmetic for hair of the present invention, a remarkable effect was observed in the blood flow test, and a 95% effect was observed in the hair growth test.

Example 13 Hair Nourishing Lotion Compounding Amount (% by Weight) 95% Ethanol 45.0 Dimethylamine Oxide (I) 10.0 Caffeine 0.15 Benzyl Nicotinate 0.05 Aspartic Acid 0.05 Parabutylene Glycol 2.0 Maltitol 8.0 Polyethylene glycol 400 2.0 Propyl paraben 0.05 Sodium hexametaphosphate Appropriate amount Sodium palmitate 0.3 Appropriate flavor and pigment Appropriate amount

<Production method> A drug (oil-soluble), parabutylene glycol, polyethylene glycol 400, propylparaben and a flavor are dissolved in 95% ethanol, and then aspartic acid, maltitol, sodium hexametaphosphate and sodium palmitate are dissolved in purified water. After the addition of the dye and the dye, the mixture was dissolved. After adding this aqueous phase to the alcohol phase,
By stirring, a clear liquid lotion was obtained.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, an extremely remarkable effect was recognized in the blood flow test, and a 90% effect was recognized in the hair growth test.

Example 14 Scalp Massage Agent Compounding Amount (% by Weight) 95% Ethanol 45.0 Dimethylamine Oxide (I) 1.0 Nicotinamide 0.8 Benzyl Nicotinate 0.05 Dynamite Glycerin 5.0 1 , 3-butylene glycol 8.0 dipropylene glycol 4.5 thickener 3.0 methyl paraben 0.2 perfume and pigment

<Production Method> A thickener was added to a part of purified water to dissolve and thicken, and then a dye dissolved in purified water was added separately.
Dynamite glycerin, 1,3-butylene glycol, and dipropylene glycol were added to and mixed with the aqueous phase. A drug dissolved in 95% ethanol, methylparaben, and a fragrance were added, and the mixture was stirred to give a gel-like scalp massage. Agent was obtained.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a remarkable effect was recognized in the blood flow test, and a 90% effect was recognized in the hair growth test.

[0052]

According to the present invention, there is provided a cosmetic for hair having an excellent blood flow promoting effect and excellent safety.

Claims (2)

[Claims] 1. A blood flow promoting component and dimethylamine oxide represented by the following formula (I): A hair cosmetic composition comprising: 2. The hair according to claim 1, wherein the blood flow promoting component is one or more blood flow promoting components selected from the group consisting of nicotinic acids, minoxidil and assembly extracts. Cosmetics.