JP3220761B2 - Hair restoration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer having an excellent hair growth-inhibiting effect such as hair loss prevention and hair growth. The invention finds particular use in the pharmaceutical, quasi-drug or cosmetics fields.

[0002]

2. Description of the Related Art Conventionally, causes of baldness and hair loss include activation of male hormones in organs such as hair roots and sebaceous glands, a decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxide. Abnormalities of the scalp are considered. For this reason, a compound having an action of removing or reducing the above-mentioned causes is generally added to the conventional hair restoration. For example, vitamins such as vitamin B and vitamin E, serine,
Amino acids such as methionine, vasodilators such as assembly extract and acetylcholine derivatives, anti-inflammatory agents such as purple root extract and hinokitiol, female hormones such as estradiol, and skin function enhancers such as cepharanthin are combined to prevent alopecia. And is used for treatment.

[0003]

However, in spite of various attempts as described above, conventional hair restorers do not always have sufficient hair-growth effects such as hair loss prevention and hair-growth effects. Was. This is probably due to a variety of causes of hair loss and the very complex mechanism of hair growth.

[0004] In view of the insufficient hair-growth effect as described above, the present inventor has searched for a substance that is effective for hair loss and has an excellent hair-growth preventing effect and a hair-growth effect. As a result, they have found that a special plant extract has strong hair loss prevention, hair growth and hair growth effects, and have completed the present invention.

[0005]

Means for Solving the Problems That is, the present invention is, Mallotus japonicus, Altea, Sa Nkirai, shea Nanoki, ivy, sacrum, Teng Nan Shaw, one or more plant extracts selected from Mo Kkou The present invention provides a hair tonic characterized by containing.

Hereinafter, the configuration of the present invention will be described in detail. Examples of the plant extract used in the present invention include bark of Akamegawashi (Malutus japonica Mueller Arg.) And bark of Altea (Below odor) [Althaes officinalis].
L.], support Nkirai (Sankirai) [Smilax glabraRoxburg
tubers of h], shea Nanoki [Tilia sylvestris L.] of flowers, ivy (Tokoharu ivy) foliage of [Hedera helix], sacrum (high bone, river bone) [Nuphar japonicum De Cand
olle] rhizome, Tennanshaw (Tennan star) [Arisaemahe
tubers of terophyllum Blume], model Kkou (climate) [Sauss
urea lappa Clarke].

The crude drug extract used in the present invention may be prepared by using a crude drug as a solvent, for example, hot water, a lower alcohol such as methanol or ethanol, a water-containing lower alcohol, a propylene glycol, a polyhydric alcohol such as 1-3 butylene glycol, or the like. It is obtained by extraction with a water-containing alcohol such as a water-containing polyhydric alcohol.

[0008] The amount of the plant extract in the present invention is preferably 0.005 to 20% by weight, more preferably 0.01 to 5% by weight, as a dry matter, based on the total amount of the hair restorer.
If the amount is less than 0.005% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation. In addition, the dose in the case of the transdermal administration method cannot be clearly determined because it varies depending on the age, individual difference, medical condition, etc. However, in general, the dose for administration to humans is 1 kg body weight and 0 kg / day. 0.01 to 100 mg, preferably 0.1 to 10 mg, and this amount can be administered once a day or divided into 2 to 4 times.

[0009] The present invention according to hair tonic fee above Mallotus japonicus, Altea, Sa Nkirai, shea Nanoki, ivy, sacrum, Teng Nan Shaw, one plant extract selected from Mo Kkou or two or more other, carpronium chloride , Vasodilator such as assembly extract, acetylcholine derivative, amino acids such as serine and methionine, vitamin B6, vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid and its derivatives, benzyl nicotinate And nicotinic acid esters, skin function enhancers such as cepharanthin, female hormones such as estradiol, and the like. Further, additives usually used for hair restoration, for example, hinokitiol, hexachlorophen, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bitionol, refreshing agents such as menthol, salicylic acid, Drugs such as zinc and its derivatives, lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, oils such as higher alcohols, glycerin, propylene Polyhydric alcohols such as glycols, other surfactants, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, humectants, thickeners and the like may be appropriately blended within a range that does not impair the effects of the present invention. it can.

The properties of the hair restorer of the present invention may be any properties such as liquid, emulsion, ointment and the like which can be applied to the outer skin.

[0011]

EXAMPLES The production method and hair-growing action of the hair-growing agent of the present invention will be described more specifically with reference to the following examples. The present invention is not limited by this. The compounding amount is% by weight.

Examples 1 to 9 and Comparative Examples 1 and 2 are shown in Tables 1 to 3.
Shown in The manufacturing method will be described below. To 95% ethanol, ion-exchanged water of each plant extract (methanol extract) and adduct of hydrogenated castor oil ethylene oxide (40 mol) were added, and the mixture was dissolved by stirring. Then, ion-exchanged water was added and mixed. Hair restoration was obtained. Example 2 and Comparative Example 1 were obtained in the same manner as in Example 1. Examples 3-9 and Comparative Example 2 were hydrogenated castor oil ethylene oxide (40 moles)
A liquid hair nourishing product was obtained without using the adduct.

[0013]

[Table 1]

[0014]

[Table 2]

[0015]

[Table 3]

(Hair Growth Test) The hair growth tests of Examples 1 to 9 and Comparative Examples 1 and 2 were carried out using C3H / He in the telogen of the hair cycle.
Using NCrJ mice, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiatio
n], edited by M. Seiji and IABernstein, No. 159-
170 pages, 1982, The University of Tokyo Press). That is, a group of 10 mice was not applied, divided into groups of Examples 1 to 9 and Comparative Examples 1 and 2, the back of the mouse was shaved with a clipper and a shaver, and each sample was collected once a day. Each 0.1 ml was applied. The hair growth effect of each sample was measured by measuring the hair growth portion on the back of the mouse, and was compared based on the area ratio. Table 4 shows the number of days required for the 50% hair growth rate by each sample.

[0017]

[Table 4]

As described above, the hair restoration according to the present invention comprises:
Has an excellent hair growth effect.

(Hair-growth test) In order to examine the hair-growth effects such as the hair loss-prevention and the hair-growth effects of the hair-growth composition of the present invention, a tricogram test was carried out on humans. Examples 1 and 2 and Comparative Example 1 were used for the hair restoration.

(Trichogram test) Before and after use of the hair restoration, the roots of the removed hair are observed under a microscope, and the number of telogens in the telogen is counted from the form of the hair root. The effects were compared. A telogen follicle is a hair follicle that has stopped growing, and it has been recognized that the proportion of this telogen follicle is higher in people who report hair loss than in normal people. Each of the hair restorations of Examples 1 and 2 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml at a time, continuously for 6 months, immediately before the application and immediately after the completion of the application for 6 months. One hundred hairs were removed from each subject, and the hair roots were examined. Table 5 shows the results.

[0021]

[Table 5]

As described above, the hair restoration according to the present invention has an excellent hair restoration action. In addition, in Examples 3 to 9 , actual use tests were performed on humans in the same manner as in Example 1.
It was confirmed that the hair-growing action was excellent.

Example 10 (Phase A) Liquid paraffin 10.5 Glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propyl paraben 0.3 Fragrance 0.1 (Phase B) Dry Ethanol Extract of 0.5 Glycerin 10.0 Dipropylene Glycol 18.0 Polyethylene Glycol 4000 5.0 Sodium Hexametaphosphate 0.005 Deionized Water 54.595 (Production Method) A phase and B phase are heated and dissolved respectively. The mixture was mixed and emulsified with a homomixer to obtain a creamy hair restorer. As a result of an actual use test of this hair restoring agent on a person in the same manner as in Example 1, it was confirmed that the hair restoring effect was excellent.

Example 11 Dry matter of ethanol extract of Kizuta 0.5 Dry matter of 50% ethanol extract of Mokko 0.3 Dry matter of 50% methanol extract of linden 0.1 Dry matter of propanol extract of Dicoppi 0.1 Tennanshaw 0.1% dry matter of methanol extract of 70% ethanol extract of hardened castor oil 0.03 Hardened castor oil ethylene oxide (40 mol) adduct 2.0 95% ethanol 54.0 Deionized water Remainder (Production method) Ionize 95% ethanol Exchanged water is added, hydrogenated castor oil ethylene oxide (40 mol) adduct is added thereto, and then each plant extract is added and stirred to dissolve. As a result of an actual use test of this hair restoring agent on a person in the same manner as in Example 1, it was confirmed that the hair restoring effect was excellent.

[0025]

The hair restorer of the present invention is a hair restorer having an excellent hair restorer effect.

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-55-49305 (JP, A) JP-A-60-255715 (JP, A) JP-A-62-190115 (JP, A) JP-A-63- 57513 (JP, A) JP-A-2-48514 (JP, A) JP-A-3-284614 (JP, A) French patent 1443889 (FR, B) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/00-7/50

Claims (2)

(57) [Claims] Claims: 1. Acamega wrinkles, Altea, Sankirai,
Linden, Te N'nanshou, hair tonic charge, characterized by containing one or more plant extracts selected from woodworking. 2. A red pike, Altea, Sankirai,
Linden, edible plant, senkotsu, tennansho
C, one or two plant extracts selected from Mokko
Hair loss prevention and development characterized by containing as an active ingredient
Cosmetic for scalp to promote hair and hair growth.