JPH0352806A - Hair-raising agent - Google Patents

Abstract

PURPOSE:To provide a hair-raising agent having excellent hair-raising activities such as alopecia-preventing activity and trichogenous activity by mixing nicotinic alcohol as an active ingredient. CONSTITUTION:A hair-raising agent contains 0.001-20wt.%, preferably 0.110wt.%, of nicotinic alcohol (three isomers of chemical names: 2-pyridinemethanol, 3- pyridinemethanol and 4-pyridinemethanol) as an active ingredient. The hair- raising agent may further contain a vasodilator, an amino acid, a vitamin, a skin function-accelerating agent, etc., and is more further suitably compounded with conventional additives for hair-raising agents to provide the objective agent. The agent can be prepared into a preparation such as a liquid, emulsion or ointment applicable to exodermis and is administered in an amount of 0.01-100mg/day.kg of a body 2-4 times a day.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair nourishing product that has excellent hair nourishing effects such as hair loss prevention and hair growth effects. The present invention is particularly applicable to pharmaceuticals, quasi-drugs,
Or used in the cosmetics field.

Conventional Technology 1 Conventional causes of baldness and hair loss include activation of male hormones in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and production of peroxides. Scalp abnormalities are suspected.

For this reason, conventional hair nourishing products generally contain compounds that have the effect of eliminating or alleviating the above-mentioned causes.

For example, vitamins such as vitamin B8 and vitamin E, amino acids such as serine and methionine, vasodilators such as Oriental japonica extract, acetylcholine derivatives, purple root extract, anti-inflammatory agents such as hinokitiol, female hormones such as estradiol, cephalanthine, etc. It is formulated with skin function enhancers and is used for the prevention and treatment of alopecia.

[Problems to be solved by the invention] - However, despite various attempts as described above, conventional hair nourishing products have no hair nourishing effects such as hair loss prevention and hair growth effects. It wasn't always enough.

This is probably because the causes of hair loss are various and the mechanism of hair growth is also very complex.

In view of the insufficient hair growth effect as described above, the present inventors have developed a method that is effective against hair loss and excellent in preventing hair loss.
As a result of searching for substances that have a hair-growth effect and other hair-nourishing effects, the inventors discovered that nicotinic alcohol has a strong hair-nourishing effect, leading to the completion of the present invention.

[Means for Solving the Problems] That is, the present invention provides a hair nourishment characterized by containing nicotinic alcohol as an active ingredient.

Hereinafter, the configuration of the present invention will be explained in detail.

The nicotinic alcohol used in the present invention has three chemical names: 2-pyridine methanol, 3-pyridine methanol, and 4-pyridine methanol, and among these, 3-pyridine methanol is particularly preferred.

2-pyridine methanol, 3-pyridine methanol, and 4-pyridine methanol used in the present invention are obtained by known methods, and the blending amounts are as follows in the hair nourishment of the present invention:
It is 0.001 to 20% by weight, preferably 0.1 to 10% by weight. If it is less than 0.001% by weight, the effect of the present invention cannot be sufficiently obtained, and if it exceeds 20% by weight, it is unfavorable in terms of formulation.

In addition to the above-mentioned viridine methanol, the hair nourishing agents according to the present invention include vasodilators such as rubronium chloride, Oriental japonica extract, and acetylcholine inducers, amino acids such as serine and methionine, vitamin BS, vitamin E and its derivatives, and biotin. Vitamin deposits such as bantothenic acid and its derivatives,
Glycyrrhetinic acid and its derivatives, nicotinic acid esters such as henzil nicotinate, skin function enhancers such as cephalanthine, female hormones such as estradiol, etc. may be simultaneously blended. Additionally, additives commonly used in hair care, such as antibacterial agents such as hinokitiol, hexagonal chloride, penzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlororuvanilide, and pithionol, and cooling agents such as menthol;
Salicylic acid, zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isoprobyl myristate, higher fatty acids, higher alcohols, Polyhydric alcohols such as glycerin and propylene glycol, other surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water,
Moisturizers, thickeners, and the like can be added as appropriate to the extent that they do not impair the effects of the present invention.

The hair nourishing product of the present invention may have any shape as long as it can be applied to the outer skin, such as wavy, milky lotion, or ointment.

The hair care treatment of the present invention employs a transdermal administration method in which it is directly applied or sprayed on the skin. In addition, the dosage of the hair nourishing agent of the tree invention cannot be clearly determined as it varies depending on age, individual differences, medical conditions, etc., but in general, the dosage when administered to humans is 0.01 to 1 kg per body weight and per day. The amount is 100 mg, preferably 0.1 to 10 mg, and this amount can be administered once a day or in 2 to 4 divided doses.

[Example] Next, the method for producing the hair nourishing agent and the hair nourishing effect of the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is 5% by weight. (Production method) Add 3-pyridine methanol and hydrogenated castor oil ethylene oxide (40 mol) adduct to 95% ethanol, stir and dissolve, then add ion-exchanged water and mix. Liquid hair growth of Example 1 was obtained. Examples 2 to 12 and Comparative Example 1 were also obtained in the same manner as Example 1.

[Hair Growth Test] The hair growth tests of Examples 1 to 12 and Comparative Example 1 were conducted using C3H/HeNCrJ mice in the resting phase of the hair cycle using the method of Ogawa et al.
d Abnormal Epidermal D
ifference], M. Seiji and I. A. Edited by Bernstein, No. 159-170
Page, 1982, University of Tokyo Press).

That is, there were 10 mice in group l, no application, Example 1.
The mice were divided into 13 groups (12 to 12 and Comparative Example 1), the backs of the mice were shaved with clippers and a shaver, and 0.1 ml of each sample was applied once a day. The hair growth effect of each sample was compared by measuring the hair growth area on the back of the mouse and comparing the area ratio. Table 3 shows the number of days required for 50% hair growth rate for each sample.

Table 3 Mouse hair growth test results As mentioned above, The hair care department related to the present invention is Excellent It has a hair growth effect.

[Hair nourishing effect test] Next, in order to examine the hair nourishing effects such as hair loss prevention and hair growth effects of the hair restorer of the present invention, a tricogram test was conducted on humans. The test was carried out on the hair nourishing products of Examples 1 to 12 and Comparative Example (2).

(Trichogram test) Observe the removed hair roots under a microscope before and after using the hair tonic, count the number of resting hair roots from the shape of the hair root, and determine the hair nourishing effect of the hair tonic by increasing or decreasing the ratio. compared. Telogen hair roots are hair roots that have stopped growing, and it is recognized that people who complain of hair loss have a higher proportion of hair roots in the telogen phase than normal people.

Each of the hair nourishing agents of Examples 1 to 12 and Comparative Example 1 was applied to the scalps of 10 male subjects twice a day at a rate of 2 ml each time for 6 months, immediately before application and immediately after the end of 6 months of application. One hundred hairs were removed from each subject, and the roots of each hair were examined. The results are shown in Table 4.

Table 4 Trichogram test results As described above, the hair nourishing agent according to the present invention has an excellent hair nourishing effect.

Example 13 (Phase A) 3-pyridine methanol polyoxyethylene (60 mol) with calohydrogenated castor oil glycerin dibrobylene glycol 1,3-butylene glycol polyethylene glycol 1500 (Phase B) cetyl isooctane squalane vaseline probil Paraben (phase C) Carpoxyvinyl polymer 1% aqueous solution Sodium hexametaphosphate ion-exchanged water 1.0 2.0 10.0 10.0 5.0 5.0 10.0 5.0 2.0 2.0 30 .0 0.03 8,35 (D phase) Ion exchange water (E phase) Caustic ion exchange water 4.5 0.12 5.0 (Production method) Phase A and phase B were dissolved by heating at 60°C. , mix and process with a homomixer to make a gel. Phase I) is gradually added to this and dispersed using a homomixer.

Next, the dissolved phase C was added thereto, and finally the dissolved phase E was added and emulsified with a homomixer to obtain an O/W emulsion type hair nourishment.

When this hair nourishing agent was tested on humans in the same manner as in Example 1, it was confirmed that its hair nourishing effect was excellent.

Example 14 (Phase A) 3-pyridine methanol 5.0 Liquid paraffin 5.0 Cetostearyl alcohol 5,5 Glyceryl monostearate 3.0 EO (20 mol) -2-
Octyl Dodecyl Ether 3.0 Probylparaben
0.3 fragrance
0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate o. oos ion exchange water
45.095 (Production method) Phase A and phase B were respectively heated and dissolved and mixed, and emulsified with a homomixer to obtain a cream-like hair nourishing agent.

When this hair nourishing agent was tested on humans in the same manner as in Example 1, it was confirmed that the hair nourishing effect was excellent.

Example 15 (Phase A) 4-pyridine methanol 10.0 Liquid paraffin 10.5 Glyceryl monostearate 3.0 EO (20 mol) -2
-Octyldodecyl ether 3.0 probylbaraben
0.3 fragrance
0.1 (Phase B) Glycerin 10.0 Dipropylene glycol 18.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion exchange water
45.095 (Production method) Phase A and phase B were respectively heated and dissolved and mixed, and emulsified with a homomixer to obtain a cream-like hair nourishing agent.

When this hair growth product was tested on humans in the same manner as in Example 1, it was confirmed that its hair growth effect was excellent.

Example 16 (Phase A) 2-Pyridine Methanol Polyoxyethylene (60 mol) Caloride Castor Oil Glycerin 1,3-Butylene Glycol Polyethylene Glycol 1500 (Phase B) Cetyl Isooctanate Petrolatum Probyl Paraben (Phase C) Carboxy Vinyl polymer ■% water soluble < night hexametaphosphate sodium ion exchange water (D phase) ion exchange water (E phase) 10.0 2.0 10.0 5.0 5.0 10.0 8.0 2.0 30. O O. 03 8.35 4.5 Caustic ion-exchanged water 0.12 5.0 (Manufacturing method) Phase A and phase B are respectively heated and dissolved at 60°C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed using a homomixer.

Next, the dissolved phase C was added thereto, and finally the dissolved phase E was added and emulsified with a homomixer to obtain an O/W emulsion type hair nourishment.

When this hair nourishing agent was tested on humans in the same manner as in Example 1, it was confirmed that its hair nourishing effect was excellent.

[Effect of the invention] The hair nourishing material of the present invention is a hair nourishing material having an excellent hair nourishing effect.

Claims (1)

[Claims] A hair nourishing agent characterized by containing nicotinic alcohol as an active ingredient.