JPH09241137A - Hair crowing and restoring agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair growing and restoring agent hawing a hair restoring function such as excellent prevention against loss of hair, chromogenic effect, etc., by combining an extract of an innocuous and stable specific crude drug with a cell activator or a promoter for circulation of blood. SOLUTION: This agent is prepared by combining one or more than two kinds of substances selected from a group consisting of an extract of Houttuynid cordata (Saururaceae Houttuynid cordata), and extract of Lindera strychinifolia F. Viel (Lauraceae Lindera strychinifolia F. Viel), an extract of bark of cherry tree (Rosaceae Prunus jamasakura Sieb. et Koizumi) and carnitine chloride with one or more than two kinds of cell activators and promoters for circulation of blood. As the cell activator, pantothenic acid and its derivative, a sensitizing dye 301, an extract of ginseng, biotin, etc., are illustrated. The blending amount is about 0.001-10weight%. As the promoter for circulation of blood, e.g. carpronium chloride, an extract of Swertia japonica, a tincture of Capsicum annum, etc.. are illustrated. The blending amount is about 0.001-10weight%. Moreover, the blending amount of the above crude drug is about 0.001-10weight%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing / hair-growth agent having excellent hair-removing effects such as hair loss prevention and hair growth effect.

[0002]

2. Description of the Related Art Conventionally, baldness and hair loss have been caused by activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxide in the scalp. Abnormalities etc. are considered. For this reason, conventional hair nourishing and hair-growth agents are blended with components that remove or reduce the above causes.

[0003]

Problems to be Solved by the Invention However, conventional hair-growth and hair-growth agents do not always have sufficient hair-growth effects such as hair loss prevention and hair-growth effects.

[0004]

Means and Actions for Solving the Problems The present inventors have searched for substances having excellent hair loss prevention and hair growth effects in order to improve the insufficient hair nourishing action as described above. We have found a long-lasting safe hair-growth and hair-growth agent that has excellent hair loss prevention, hair-growth and hair-growth effects with medicinal extract, ebony extract, cherry bark extract and carnitine chloride.
That is, the present invention comprises one or more species selected from the group consisting of a jujuyaku extract, a mulberry extract, a cherry bark extract and carnitine chloride, and one or more species of a cell activating agent or a blood circulation promoting agent. The present invention provides a hair nourishing / hair growth agent characterized by containing the same.

Among the extracts of crude drugs used in the present invention,
The extract of the ten medicines is Houtt (Saururaceae)
uynia cordata Thunb.)
raceae) Tendai Uyaku (Lindera strychnifolia F. Vi
(el.) root and cherry bark are roseaceae (Rosaceae)
Us jamasakura Sieb. et Koizumi) bark extracted with solvent. As the extraction method, a crude drug is used as a solvent, for example, water or a lower alcohol such as methanol or ethanol or a hydrous lower alcohol or a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol or a hydrous polyhydric alcohol at room temperature or warming. Extract under conditions and purify. 1 of the manufacturing method of Juju extract
As an example, it is obtained by adding 5 parts of 50% ethanol to 1 part of dried Jujuyaku product, extracting at room temperature for 1 week, and then filtering. Carnitine chloride has the effect of promoting gastric function and is used as a gastrointestinal drug. Carpronium chloride, which has a similar chemical structure to carnitine chloride, is used as a hair restorer, but it is difficult to store for a long time because it is highly toxic and its stability is not good. On the other hand, it was found that carnitine chloride has low toxicity, good stability, and excellent hair growth effect.
When comparing oral toxicity in mice, the LD50 of carpronium chloride is 134 mg / kg, whereas the LD50 of carnitine chloride is 6690 mg / kg (Japan Pharmaceutical Information Center, Japan Pharmaceutical Collection). That is, the toxicity of carnitine chloride is 1/50 of that of carpronium chloride.

These crude drugs have been used for a long time as folk medicines and Kampo medicines for the purpose of gastrointestinal drugs, antitussives, diuretics, laxatives, etc., and are known as safe non-toxic crude drugs. However, it has not been reported that these crude drugs or compounds have hair loss prevention and hair growth effects. The active ingredient of the hair-growth / hair-growth agent of the present invention is not toxic to the human body, and therefore the amount of the hair-growth / hair-growth agent mixed is not particularly limited.
It is preferable to add 001 to 10% by weight. 0.001
If it is less than 10% by weight, the hair-growth and hair-growth effects are not sufficiently exhibited, and if it exceeds 10% by weight, a further hair-growth effect may not be expected, which is not preferable. When the present invention is carried out, it is sufficiently effective even if it is used alone, but a higher effect can be expected by using two or more kinds in combination. Further, a more excellent effect can be obtained by using it in combination with a cell activating component or a blood circulation accelerating agent which has been conventionally used for a hair growth / hair nourishing agent.

The cell activating agent usable in the present invention includes:
Pantothenic acid and its derivatives (pantothenyl ethyl ether), Photosensitizer No. 301, carrot extract, biotin,
Examples include mononitroguaiacol, hinokitiol, allantoin, and pentadecanoic acid glyceride. The amount of the cell activating agent added to the hair nourishing / hair-growing agent of the present invention is 0.001-10.
It is preferable to mix by weight%. If the amount is less than 0.001% by weight, sufficient hair-nourishing and hair-growing effects are not exhibited, and if the amount is more than 10% by weight, an unpleasant sensation is given to the scalp, which is not preferable.

The blood circulation promoter usable in the present invention includes:
Carpronium chloride, Assembly extract, Pepper tincture, Cepharanthin, Benzyl nicotinate, Garlic extract, Touki extract, Gentian extract, γ-Oryzanol, Licorice, Minoxidil, Senkyu, Ginseng ginseng, Panax ginseng, Ginger, Jio, Aloe, Spironolactone, Vitamin B ₆ hydrochloride, D-camphor, DL-camphor, DL-α-tocopherol, garlic iodide extract, DL-α-tocopherol linoleate, inositol hexanicotinate, vitamin E, dextran sulfate sodium, nicotinic acid, DL- α-tocopherol nicotinic acid ester,
Butoxyethyl nicotinate, methyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol succinate, DL-α-tocopherol acetate, capsicum tincture, cantaristin tincture, show tincture tincture, and the like, in particular, cepharanthin, DL-α -Tocopherol, garlic iodide extract, assembly extract, DL-α
-Tocopherol nicotinic acid ester, benzyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol acetate, pepper tincture, cantaris tincture, ginger tincture, and the like are preferable from the viewpoint of hair-growth effect. The amount of the blood circulation promoter added to the hair nourishing / hair-growing agent of the present invention is 0.001
It is preferable to add 10 to 10% by weight. 0.001% by weight
If it is less than 10% by weight, a sufficient hair nourishing / hair-growth effect is not exhibited, and if it is 10% by weight or more, it gives an unpleasant stimulus to the scalp, which is not preferable.

In addition to the above-mentioned active ingredients, the hair nourishing and hair-growing agents of the present invention include benzalkonium chloride, salicylic acid, chlorhexidine hydrochloride solution, Photosensitizer No. 201, Photosensitizer No. 301, chlorhexidine gluconate solution, chlorxylenol, trichloro. Antibacterial agents such as carbanilide, halocarban, mononitroguaiacol, etc., glycyrrhizin and its derivatives, diphenhydramine hydrochloride, guaiazulene, carbenoxolone disodium, shikon extract, ages, l-menthol, hydrocortisone acetate, prednisolone, etc., sodium hyaluronate. , Glycerin, sodium pyrrolidonecarboxylate, propylene glycol, mini sasanishiki extract, chondroitin sulfate, cordyceps extract, saffron extract and other moisturizers, salicylic acid, resorcinol, lactic acid, etc. Solubilizers, topical stimulant peppermint oil,
Estrone, estradiol, estrogen such as ethinyl estradiol, pyridoxine and derivatives, sulfur, thioxolone, vanside, antiseborrheic agents such as lecithin, amino acids, cystine, cysteine, methionine,
Serum, vitamins and other nutritional supplements can be added.

In addition, the hair nourishing and hair-growing agent of the present invention includes oil (isopropyl myristate, lecithin, squalane, etc.), a surfactant (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, glycerin fatty acid). Ester, etc.), polyhydric alcohol (propylene glycol, glycerin, macrogol, etc.), antioxidant (dibutyl hydroxytoluene, isopropyl gallate, etc.), sequestering agent (ethylenediamine tetraacetate or its salt, etc.), pigment, fragrance, etc. It can be blended appropriately. The hair nourishing and hair-growing agent of the present invention is applied to the scalp in an appropriate amount once to several times a day for use. Further, the dosage form of the hair nourishing / hair-growing agent of the present invention is not particularly limited, and conventionally known hair tonics, hair lotions, hair creams, aerosols, ointments and the like are possible.

[0011]

EXAMPLES Next, examples of the present invention will be described, but the present invention is not limited to these examples.

<Hair Growth Test> C at 7 weeks of age in the resting period
The back hair of 3H mouse (♂) was shaved over 2 × 4 cm ² using an electric clipper and an electric razor. A group of 10 mice was prepared, and 0.1 ml each of the mice was applied to the shaving site once a day, and Examples 1 to 4 and Comparative Examples 1 and 2 shown in Table 1 were used.
Of the hair nourishing and hair-growth agent was applied. In order to observe the state of hair regeneration, a photograph of the above shaved site was taken at a fixed magnification, and the ratio of the regenerated hair area (regenerated hair area / shaved area) was calculated using an image analyzer. Table 1 shows the average value of the regenerated hair area ratio (%) of each group on the 14th day after the start of the sample application.

[0013]

[Table 1]

As shown in Table 1, the products of the present invention (Examples 1 to 1)
In 4), a remarkable hair growth effect was recognized as compared with the comparative product (Comparative Examples 1 and 2).

<Practical test>

(Evaluation method) Using the hair nourishing and hair-growth agents of Examples 1 to 4 and Comparative Examples 1 and 2 shown in Table 1, 10 men each with a lot of hair loss and anxious dandruff and itching on a daily basis ( 25-50
Aged) were tested for the effect of preventing hair loss, dandruff and itching. The method of use was basically twice a day, in the morning and before bedtime. When the hair was washed, an appropriate amount was applied to the scalp after the hair was washed and massaged. In addition, during the test period, we asked commercial shampoos to be used uniformly, and other rinsing agents,
Use of tonics, hairdressing agents, and treatments for perms and hair dyes were banned. Judgment of the effect is performed by a hairdresser once every two weeks, hair that has fallen off during hair washing is collected, the number of hair loss is measured, and the state of the hair root is observed and classified.
After the hairdresser's hair was washed, the condition was evaluated 48 hours later, and the presence or absence and degree of itch were confirmed by the consciousness of the person. The results were evaluated according to the following criteria, and the results are shown in Table 2.

(Evaluation Criteria) (1) Hair Loss-Effective ... The number of hair loss is decreasing. The hair root is a clean club-shaped normal hair root. Invalid: The number of hair loss has not changed or has increased. Hair roots are abnormal hair roots with atrophy and deformation. (2) Dandruff (visual judgment) ・ Valid… Slightly dandruff-No dandruff is observed. ・ Invalid… Very dandruff is occurring ～ Drunk. (3) Itching (identity) ・ Valid ... Itching that you will forget after a while-You will not feel itching-Invalid ... There is itching that you can not stand-You can endure itching

[0018]

[Table 2]

As shown in Table 2, Examples 1 to 4 of the present invention
In comparison with Comparative Examples 1 and 2, a remarkable effect in preventing hair loss, dandruff, and itch was recognized. Furthermore, Examples 5 to 1 below
The hair nourishing and hair-growing agents of No. 6 are shown, and as in Example 1, remarkable effects were observed in hair loss prevention, dandruff, and itch prevention.

Example 5 Weight part Ethanol 65 Propylene glycol 5 Jujutsu extract 3 Photosensitizer No. 301 0.1 Minoxidil 0.5 DL-α-tocopherol linoleic acid ester 0.1 Purified water Appropriate amount Lotion type hair nourishing / A hair restorer was prepared.

Example 6 parts by weight Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 1 Glycerin 5 Grape extract 2 Carrot extract 0.2 Assembly extract 0.2 Diisopropanolamine 0.4 Purified water Appropriate amount The above gel type nutrient A hair / hair growth agent was prepared.

Example 7 parts by weight polyoxyethylene (20) sorbitan monostearate 5 sorbitan monostearate 3 cetanol 2 stearyl alcohol 2 liquid paraffin 10 cherry bark extract 5 vitamin E acetate 0.2 minoxidil 1 pantotenyl ethyl ether 0 .5 Inositol hexanicotinic acid ester 0.1 Methyl paraoxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above-mentioned cream type hair nourishing / hair-growing agent was prepared.

Example 8 parts by weight cherry bark extract 2 carnitine chloride 2 hinokitiol 0.5 cepharanthin 0.5 benzyl nicotinate 0.3 ginseng 0.1 propylene glycol 5 polyoxyethylene (20) monooleate 5 ethanol 50 liquefied petroleum gas 4 Purified Water Appropriate amount The above aerosol type hair nourishing and hair-growing agent was prepared.

Example 9 Parts by Weight Carboxyvinyl Polymer 0.4 Ethanol 40 Propylene Glycol 5 Diisopropanolamine 0.4 Jujube Extract 2 Oyster Extract 3 Biotin 0.5 Capsicum tincture 0.3 Cepharanthin 0.3 Vitamin E 0.1 Nicotinic acid 0.1 Purified water Appropriate amount The above gel-type hair nourishing / hair-growing agent was prepared.

Example 10 parts by weight Jujutsu extract 3 cherry bark extract 3 mononitroguaiacol 1 benzyl nicotinate 0.5 garlic extract 0.1 1,3-butanediol 2 propylene glycol 4 polyoxyethylene (20) poly Oxypropylene (6) Decyl tetradecyl ether 3 Ethanol 55 Purified water Appropriate amount The above-mentioned lotion type hair nourishing and hair-growing agent was prepared.

Example 11 10 parts by weight Jujube extract 3 Carnitine chloride 2 Allantoin 0.2 Touki extract 0.1 Spironolactone 0.1 Gentiana extract 0.1 Glycyrrhetinic acid 0.2 Glyceryl monoisostearate 1 Propylene glycol 5 Polyoxy Ethylene (20) sorbitan mono oleate 1.5 Ethanol 70 Purified water Appropriate amount The above-mentioned lotion-type hair nourishing / hair-growing agent was prepared.

Example 12 parts by weight Gourd extract 5 Cherry bark extract 3 Pentadecanoic acid glyceride 0.1 γ-Oryzanol 0.1 Glycyrrhiza 0.2 Butoxyethyl nicotinate 0.1 Ethanol 65 Propylene glycol 5 Purified water Appropriate amount Above A lotion type hair nourishing / hair-growing agent was prepared.

Example 13 parts by weight Karasu extract 3 carnitine chloride 1 senkyu 0.1 chixetuni ginseng 0.1 ginger 0.1 dio 0.1 aloe 0.5 carboxyvinyl polymer 0.4 ethanol 40 propylene glycol 1 glycerin 5 Diisopropanolamine 0.4 Purified water Appropriate amount The above gel-type hair-growth / hair-growth agent was prepared.

Example 14 parts by weight cherry bark extract 3 carnitine chloride 2 vitamin B ₆ hydrochloride 0.1 DL-camphor 0.2 DL-α-tocopherol 0.2 methyl nicotinate 0.1 polyoxyethylene (20) Sorbitan monostearate 5 Sorbitan monostearate 3 Cetanol 2 Stearyl alcohol 2 Liquid paraffin 10 Methyl paraoxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above cream-type hair-growth and hair-growth agents were prepared.

Example 15 parts by weight Jujuyaku extract 1 Karasuyaku extract 1 Cherry bark extract 1 Nonanoic acid vanillyl amide 0.1 DL-α-tocopherol succinate 0.1 DL-α-tocopherol acetate 0.2 Capsicum tincture 0.1 Cantharis tincture 0.1 1,3-Butanediol 5 Polyoxyethylene (60) hydrogenated castor oil 0.4 Octyldodecyl myristate 1 Glyceryl monoisostearate 1 Ethanol 65 Purified water Appropriate amount Lotion-type hair nourishment・ Prepared a hair restorer.

Example 16 parts by weight Jujuyaku extract 5 Karasu extract 2 Carnitine chloride 2 Garlic iodide extract 0.1 DL-α-tocopherol nicotinic acid ester 0.1 Ginger tincture 0.2 D-camphor 0. 1 Sodium dextran sulfate, 0.5 Propylene glycol 5 Polyoxyethylene (20) monooleate 5 Ethanol 50 Liquefied petroleum gas 4 The above aerosol-type hair-growing / hair-growing agents were prepared.

[0032]

EFFECTS OF THE INVENTION One or more kinds selected from the group consisting of jujuyaku extract, mulberry extract, cherry bark extract and carnitine chloride, and one or more kinds of cell activating agent or blood circulation promoter are blended. By doing so, it is possible to provide a hair-growth / hair-growth agent that has excellent hair loss prevention, hair-growth / hair-growth effects, and long-term safety.

Claims (1)

[Claims] 1. One or more than one selected from the group consisting of jujuyaku extract, uruyaku extract, cherry bark extract and carnitine chloride,
And a hair nourishing / hair-restoring agent containing one or more cell activating agents or blood circulation promoting agents.